ライフサイエンスコーパス: cell composition

1 variations in microbial responses and immune cell composition.

2 finity tags, or a priori knowledge of target cell composition.

3 d QC pipeline was applied and used to impute cell composition.

4 y by identifying tissue-of-origin and immune cell composition.

5 ed and young brains differed in their immune cell composition.

6 emonstrated similarities in adrenergic tumor cell composition.

7 e literature, mainly through their impact on cell composition.

8 evant immune checkpoint molecules and immune cell composition.

9 rmine which inhibitor blocked the changes in cell composition.

10 susceptibility to T1D significantly affect T cell composition.

11 rving their morphology, cytoarchitecture and cell composition.

12 c DNA adducts, tumour initiation, and immune cell composition.

13 elated to clinical outcome as well as immune cell composition.

14 recapitulate the tumor and microenvironment cell composition.

15 ns adjusting for sex, age, cohort, and blood cell composition.

16 specific as well as shared features in tooth cell composition.

17 inal tissue dynamics, microbiome, and immune cell composition.

18 e integrity, epithelial activity, and immune cell composition.

19 ndings and their impact on the leukapheresis cell composition.

20 ence-free deconvolution" methods to estimate cell composition.

21 utational load as well as stromal and immune cell composition.

22 fluorescence-activated cell sorting assessed cell composition.

23 d "shotgun" cellular coverage of its somatic cell composition.

24 dden confounding variation, most importantly cell composition.

25 rom blood samples suffer from variability of cell composition.

26 odels of aging that are independent of blood cell composition.

27 pe of the discharge profile as a function of cell composition.

28 ides a deeper and more complete knowledge of cell composition.

29 erences in T-cell activation or peripheral T-cell composition.

30 ates might be simply the result of a changed cell composition.

31 and often provide obscure information on the cell composition.

32 be tuned using electromechanical stimuli and cell composition.

33 , the strength of which depends on the local cell composition.

34 stitial pattern of infiltrates with variable cell composition.

35 iable integration of datasets with different cell compositions.

36 It assumes that paired samples have similar cell compositions.

37 ct and remove outliers before estimating the cell compositions.

38 ailable and compared them with the estimated cell compositions.

39 in the cardiovascular system's innate immune cells' composition.

40 f age, sex, season and genetic ancestry on T cell composition, a polyfunctional type 17 helper T (T(H

41 onvolution methods are needed to infer their cell compositions accurately.

42 The large heterogeneity in immune cell composition across rejection types prevented superv

43 Estimates of cell composition across the samples in the training set

44 1), we performed harmonized reprocessing and cell composition-adjusted differential gene and transcri

45 Alterations in B cell composition after CHMI closely resembled those obse

46 in SAT was demonstrated by preserved immune cell composition after short-term CR-induced weight loss

47 Consistent with effector cell compositions, allo-SC and allo-SC/BMC each induced

48 Cell composition also changed significantly, with increa

49 non-species-specific dyes to perform de novo cell composition analysis and detect changes between dif

50 This may allow for cell composition analysis and dosing to optimize the ben

51 ll receptor (TCR) sequencing to study immune cell composition and (hyper-)expansion of circulating an

52 lopment of the disease and changes in immune cell composition and activity were monitored using flow

53 ells and sensory neurons, recapitulating the cell composition and architecture of fetal skin tissue a

54 These tissues recapitulate much of the cell composition and architecture of the in vivo organ f

55 Immunohistochemical stainings showed altered cell composition and architecture of the thymic medulla

56 Metaplastic replacement of epithelial cell composition and architecture was paralleled by chan

57 Our aim was to examine gastric T-cell composition and associated cytokine levels of patie

58 The lack of correlation between immune cell composition and Banff-defined rejection types was v

59 analysis of whole, nondissociated islets for cell composition and beta-cell apoptosis using laser sca

60 In conclusion, altered T cell composition and CD276 expression in WLWH may contri

61 However, the CNS inflammatory cell composition and CD8(+) T-cell effector functions we

62 To chart cell composition and cell state changes that occur durin

63 on of individual cells in situ to reveal how cell composition and cell states can be affected by loca

64 f cell populations and assess variability in cell composition and cell-specific gene expression in th

65 lgorithms were applied on the overall immune cell composition and compared with the Banff phenotypes.

66 estigated for its effect on peripheral blood cell composition and cytokine levels in OA patients.

67 d methacholine, bronchoalveolar lavage fluid cell composition and cytokine levels, and lung inflammat

68 tumor models within 24 h; (2) control tumor cell composition and density; (3) accurately mimic the i

69 Subtype-specific differences in immune cell composition and differential genetic/pharmacologica

70 evealed a strong association between stromal cell composition and driver gene status, resulting in di

71 rococcaceae exhibited distinct patterns of T cell composition and epithelial transcription.

72 -excluded tumors differ markedly in their T cell composition and fibroblast subsets.

73 large inter-individual variability in immune-cell composition and function determines immune response

74 tions to comprehensively identify the immune cell composition and function in NSCLC.

75 nt roles of TRIM28 in regulating endometrial cell composition and function in women, and also implies

76 Therefore, the exact cell composition and function of IAHCs remain unclear to

77 umor cell growth and invasion, alters immune cell composition and function, and contributes to stroma

78 mall and large intestines differ markedly in cell composition and function, reflecting their distinct

79 arly contribute to sex differences in immune cell composition and function, the presence of two X chr

80 tometry is used for immune cell analysis for cell composition and function.

81 Immune cell composition and functionality was analyzed accordin

82 atification of patients, encompassing immune cell composition and functionality.

83 tissues from the same specimen with similar cell composition and histology are used as control and e

84 A-seq data from human CRC, we find that both cell composition and layout features were conserved betw

85 hite AT promotes dysregulation of its immune cell composition and likely promotes low-grade chronic i

86 n their impact on LN architecture and immune cell composition and loss of colonization within gut mic

87 D9 did also not influence circulating immune cell composition and peripheral cytokine secretion.

88 r flow cytometry to assess changes in immune cell composition and phenotype.

89 equencing (scRNA-seq) to dissect and compare cell composition and progenitor-to-neuron lineage relati

90 No associations were found between immune cell composition and prostate cancer risk.

91 ed to chronic reductions in pulmonary immune cell composition and reduced type 2 immune responses and

92 mb muscles, likely because of differences in cell composition and repair mechanisms.

93 Understanding the variability of immune cell composition and responsiveness in health is critica

94 neurons, and characterization suggests that cell composition and sex are significant sources of vari

95 las and enabled us to interrogate how immune cell composition and states shift with age, chronic vira

96 ineering strategies can be used to steer the cell composition and their 3D organization within organo

97 quencing was used to assess placental immune cell composition and tissue architecture.

98 iptomes from HOMER mouse atria recapitulated cell composition and transcriptome changes observed in p

99 black x New Zealand white F1 mice analyzing cell composition and vessel formation.

100 mine effects were not accounted for by blood-cell composition and were similar for individuals expose

101 cluding B-cell activation and natural killer cell composition and/or function.

102 CB and peripheral blood (PB) have different cell compositions and characteristics, it was hypothesiz

103 l pipeline to estimate number of cell types, cell compositions and identify cell-type-specific CpG si

104 However, neural cell compositions and neurogenesis are not altered in th

105 uppression, characterized by distinct immune cell compositions and the enrichment of anti-inflammator

106 iables including psychosocial factors, blood cell composition, and asthma symptoms.

107 d we measured islet amyloid, islet endocrine cell composition, and beta-cell function.

108 l factors to variability in gene expression, cell composition, and differentiation efficiency.

109 red significant transcriptional differences, cell composition, and distinct biologic pathways in gran

110 signalling and by altering peripheral immune cell composition, and found that mouse surrogates of the

111 ides an updated understanding of airway rare cell composition, and further suggests that clinically r

112 e type 2 cytokine cellular source, gastric T-cell composition, and gastric T-cell relationship (or re

113 ly increased perinatal apoptosis, altered DG cell composition, and impaired learning and memory.

114 on of immune tolerance via a balanced immune cell composition, and maturation of the intestinal epith

115 to identify the esophageal transcriptional, cell composition, and microbial differences between the

116 We corrected for demographics, cell composition, and multiple testing (Benjamini-Hochbe

117 al blood and urine chemistries, normal blood-cell composition, and no overt behavioral and neuromuscu

118 gaps exist in terms of their size, endocrine cell composition, and number in both health and disease.

119 ion models, adjusted for age, sex, leukocyte cell composition, and other potential confounders.

120 ouseman reference-free method to correct for cell composition, and three of these sites were signific

121 clinical metadata, pathologic assessments of cell composition, and, in several cases, detailed pathol

122 Despite broadly stable hippocampal cell composition, App(NL-G-F) mice exhibit major gene ex

123 ters such as percent beta-cell apoptosis and cell composition are found to vary markedly between diff

124 tinct stromal expression patterns and immune cell compositions are identified.

125 od and marrow single-cell transcriptomes and cell compositions are largely maintained until at least

126 y treatment for analysis of peripheral blood cell composition as well as cytokine levels compared to

127 Together, our data identify differences in cell composition, as well as profoundly lower functional

128 ons suggested resilience signatures to glial cell composition (astrocytes, microglia, oligodendrocyte

129 r results describe the complex regulation of cell composition at critical stages in lineage determina

130 needs to be disentangled so as to reveal the cell compositions at that spatial spot.

131 tion, the effects of BMSC treatment on blood cell composition, brain glia and sensorimotor behavior w

132 Therefore, CMV seropositivity may alter T cell composition but does not impede the durability of h

133 = 25) of vitamin D3 were analyzed for immune cell composition by flow cytometry, Toll-like receptor (

134 d identify proportional differences in tumor cell composition by race.

135 ss dynamics in mitosis, but how dry mass and cell composition change in mitosis has remained unclear.

136 This study elucidated molecular and cell composition changes associated with increasing fibr

137 docrine features, including islet volume and cell composition, closely resembling the age-matched ND

138 ly limited changes in methylation levels and cell composition compared to controls, while a second su

139 The RM exhibited a distinct immune cell composition comprised of higher frequencies of Th2,

140 opsies replicated the subgroups, with immune cell composition confirmed via immunohistochemistry.

141 Following blood cell composition correction, we find that mtCN declines

142 s focused on myokine gene regulation, muscle cell composition, cross-tissue signaling, and interactio

143 Here, we demonstrate that the lung immune cell composition, cytokine and chemokine repertoire, his

144 over, the immune response pattern and immune cell composition did not differ between drug-induced GPP

145 Cell composition differed extensively across the brain,

146 Analysis of TME cell composition, DNA copy number, mutations and gene ex

147 The many other changes in host cell composition do not appear be used as triggers.

148 micron exhibited greater similarity in nasal cell composition driven by myeloid, T cell and SARS-CoV-

149 The substantial changes in cell composition during S-cell differentiation indicate

150 Changes in immune cell composition during the immunological window within

151 creasing interest in methods that adjust for cell composition effects when reference sets are incompl

152 notypic associations with DNA methylation by cell composition effects.

153 provide insights into cell type-specific and cell-composition effects for 450k data.

154 The impact of cell-composition effects in analysis of DNA methylation

155 itulating tissue ECM composition and stromal cell composition enhanced cancer cell invasion.

156 e also find that experimental factors change cell composition estimates and that the impact differs b

157 alyses for GTEx liver and skin samples using cell composition estimates as interaction terms, we iden

158 Computational methods for cell composition estimation are available, but they are

159 The cell composition estimation module was used to evaluate

160 sed methods provide more accurate and robust cell composition estimation than existing methods.

161 t affect atherosclerotic lesion area, immune cell composition, ex vivo cytokine secretion by peritone

162 hematopoietic stem cells (HSCs), and immune cell composition - factors that collectively contribute

163 nfirm previously described changes in immune cell composition following cladribine tablets treatment

164 al algorithms are often used to infer immune cell composition from bulk tumor transcriptome profiles.

165 convolution method which accurately estimate cell compositions from DNA methylation data without any

166 Many methods were developed for quantifying cell compositions from DNA methylation data, but they mo

167 This method combines omics and internal cell compositions from various sources to calculate the

168 apparent effects arising from differences in cell composition) from those that are not cell mediated,

169 e emerging data on the differences in immune cell composition, function and interactions within centr

170 nd Crohn's disease patients regarding immune cell composition, function and metabolism and the effect

171 t life, with ageing broadly impacting immune cell composition, function and regenerative capacity.

172 7 days later to determine circulating immune cell composition, function, and inflammatory proteins.

173 rs from primary tumors in stromal and immune cell composition, functionality, and metabolism.

174 bility to gain more refined insights such as cell composition, gene expression profiles, and differen

175 ed an in-depth analysis of changes in tissue cell composition, gene expression, and cell identities.

176 The immune cell composition had stabilized at the scaffold after ap

177 hough it has long been known that the immune cell composition has a strong prognostic and predictive

178 properly account for the mixture, estimating cell compositions has been recognized as an important fi

179 issue samples, estimating and accounting for cell composition have been recognized as important steps

180 ns in cell-level transcriptomic profiles and cell composition have emerged as critical factors influe

181 lts demonstrate that preinfection peripheral cell composition improves the prediction of symptomatic

182 inally, we evaluated peripheral blood immune cell composition in 102 children with ALL during chemoth

183 To test this hypothesis, we examined islet cell composition in a streptozotocin (STZ)-induced diabe

184 Major differences in immune cell composition in bile ducts compared to blood were re

185 we identified a shift in the overall immune cell composition in cavefish as the underlying cellular

186 mparing the thalamic visual code and retinal cell composition in closely related species occupying di

187 -cell profiling provides a means to quantify cell composition in complex mixed neural cultures and ho

188 ous studies have noted the increase of alpha-cell composition in diabetes patients and in animal mode

189 retion assays and the assessment of pancreas cell composition in health and disease.

190 The inflammatory cell composition in IL-10(-/-) mice was altered in those

191 cells rapidly induces alterations in immune cell composition in lean mice and impacts expansion of a

192 inflammatory effects of the peripheral blood cell composition in OA patients can be seen after therap

193 Because of alterations in adipose tissue T-cell composition in obesity, we aimed to identify the an

194 (T2DM) on BM microvascular and hematopoietic cell composition in patients without vascular complicati

195 tometry, morphine did not alter the lymphoid cell composition in PPs compared with placebo.

196 of PBMCs revealed substantial alterations in cell composition in SARS-CoV-2 infected infants; with mo

197 hancers and allow estimation of proportional cell composition in synthetic mixtures and improved pred

198 CIBERSORT analysis identified the immune-cell composition in the CTCL tumor microenvironment and

199 was applied to examine the changes in immune cell composition in the heart.

200 t focal infiltrates were of similar size and cell composition in the two groups but that more parasit

201 ely to account for the distinct inflammatory cell composition in uveitic eyes of WT and GKO mice.

202 and applied it to estimate the proportional cell compositions in synthetic mixtures.

203 e reveal extensive heterogeneity in CD8(+) T-cell composition, including expanded effector and post-e

204 lso produced rapid alterations in host blood cell composition, increasing both neutrophil and total w

205 erentially expressed (LDE) genes, and enable cell composition inference from histology images.

206 ion, networked pathways, and inferred immune cell compositions, information of which is beneficial fo

207 spatial organizational patterns, neighboring cell compositions, interaction networks, and transcripto

208 f high-throughput data from complex samples, cell composition is an important factor that needs to be

209 al acute liver injury phenotype, endothelial cell composition is dramatically impacted in COVID-19, c

210 The results show that the immune cell composition is fundamentally different in lung aden

211 We propose that proper LR cell composition is necessary for normal morphogenesis,

212 C/N ratio in glyphosate compared to average cell composition leading to subsequent C demand and accu

213 s (n = 12) revealed sPE-associated shifts in cell composition, manifesting as a stromal mosaic state

214 We systematically investigated cell composition, matrix, and media conditions to genera

215 Brain organoids instead have more advanced cell composition, maturation and tissue architecture.

216 nt and differences in tissue-specific immune cell composition might predispose tumors in certain tiss

217 nal behaviour and molecular landscape at the cell composition, myofibre subtype and intra-myofibre su

218 ALK4 signaling, hearts contained variable LR cell composition, not only compared with controls but al

219 ffects in blood may reflect changes in blood cell composition (notably exhausted cytotoxic T cells),

220 of islet preparations, we found a mean islet cell composition of 54.5%+/-1.2% insulin-positive, 33.9%

221 ll interactions, knowing the specific immune cell composition of a solid tumour may be essential to p

222 The treatments altered the immune cell composition of adipose tissue in obese mice.

223 Here, we defined the global immune-cell composition of cHL and nonlymphoma lymph nodes, int

224 oduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expr

225 The mean T cell composition of cultures increased from approximatel

226 our method imposes weaker assumptions on the cell composition of each individual dataset; however, it

227 The cell composition of early hepatic lesions of experimenta

228 ial reference-free algorithms for estimating cell composition of heterogeneous tissues based on their

229 ion phenotypes, the overall estimated immune cell composition of kidney transplants was ill-related t

230 revealed distinct differences in the immune cell composition of maternal lungs between term and pret

231 d sex differences, distinct organization and cell composition of nephrons dependent on the time of ne

232 Finally, analysis of the cell composition of non-small cell lung cancer samples a

233 ell genomics studies have decoded the immune cell composition of several human prenatal organs but we

234 The endocrine cell composition of the beta-cell-enriched aggregates re

235 s study has identified differences in immune cell composition of the diagnostic FL lymph node immune

236 ell injury in acute GVHD and indicate that T-cell composition of the donor marrow inoculum may influe

237 The altered immune cell composition of the female peritoneum is controlled

238 Our work unravelled the unique single cell composition of the human SN by leveraging the power

239 Here, we address the B cell composition of the ILT.

240 unofluorescence was used to characterize the cell composition of the immune response and pathways inv

241 The heterogeneous cell composition of the intradural compartment allows th

242 essential in generating the correct size and cell composition of the neocortex.

243 Morphology and cell composition of the preparation wall, pressure-volum

244 onal changes in the transcriptome and immune cell composition of the spleen, consistent with reduced

245 Finally, the initial cell composition of the tumor microenvironment varied be

246 effects in melanoma by modulating the immune cell composition of the tumor microenvironment.

247 adenocarcinoma (ADCA) exhibit unique immune cell composition of the tumor microenvironment.

248 nt magnitude correlates with the core-matrix cell compositions of the stimulated thalamic region.

249 We benchmark the impact of adipose-tissue cell composition on a range of standard analyses, includ

250 We then determined the impact of cell composition on ECT structural and functional proper

251 mediation analyses reveal a broad effect of cell composition on population disparities in immune res

252 for assessing beta-cell apoptosis and islet cell composition on serial sections of intact isolated i

253 es or other tissue-centric features, such as cell compositions or spatial relationships, and enables

254 ontrols after adjusting for gender and blood cell composition (p = 1.85 x 10(-5)).

255 ural) characteristics associated with immune cell composition perioperatively.

256 Cell composition, plasma proteins, and functional respon

257 thylation typing, sex, estimated white blood cell composition, population structure, and 5 common lif

258 we show that preserved muscle integrity and cell composition prior to the injury is necessary for th

259 des discrete changes in B and myelomonocytic cell composition, profoundly altered T cell phenotypes,

260 During the course of acute infections, T cell composition progressively changed from effector to

261 rements and technical limitations hinder the cell composition quantification using cell-sorting or si

262 FUSION provides workflows for assessing cell compositions, quantitative morphometrics, and compa

263 These results describe the complexity of the cell composition, regulation and organization for this o

264 (HM450)) and flow cytometry measurements of cell composition revealed an optimized library comprised

265 n PHEO patients (n=10), the peripheral blood cell composition showed a myeloid bias and an increase o

266 lastoids resemble blastocysts in morphology, cell composition, single-cell transcriptomes, in vitro g

267 deconvolution accuracy, accurately predicts cell composition solely from images, and identifies LDE

268 In conclusion, kidney TLS have a similar cell composition, structure, and gene signature as lymph

269 FALC's distinctive structure and stromal cell composition support a very different immune cell mi

270 diabetic mice revealed an altered endocrine cell composition that is consistent with a prominent and

271 ts suffering from COVID-19 have a distinct T cell composition that is potentially modulated by IL-6.

272 Through systematic analyses, we find cell compositions that differ substantially across regio

273 dominant role in regulating the local immune cell composition, thereby contributing to gut homeostasi

274 comprehensive longitudinal changes in immune cell composition throughout tumor progression in an epid

275 C based on KRAS dependency values and immune cell composition to improve therapeutic design.

276 las provides a comprehensive analysis of the cell composition, transcriptional signature, and interce

277 lyses revealed drastic changes in the immune cell composition upon infection with uropathogenic Esche

278 In simulation studies, adjustments for cell composition using the IDOL library resulted in unif

279 Cell-type analysis showed that cell composition varied with age: children had more mast

280 scence microscopy imaging analysis of immune cell composition, vascularization, tissue perfusion and

281 This alteration in immune cell composition was accompanied by the formation of ter

282 Cell composition was determined for 41 sensory clones, m

283 We found that cardiac cell composition was dramatically altered in mutants at

284 Immune cell composition was estimated using CIBERSORTx in human

285 populations were in part due to differential cell composition, we incorporated external single cell R

286 To mimic cardiac cell composition, we reseeded these constructs with card

287 nally, for methods not explicitly estimating cell compositions, we evaluated their performance using

288 D-L1 expression, and peripheral blood immune cell composition were also evaluated for associations wi

289 farct size, heart function, and inflammatory cell composition were analyzed in mouse models of myocar

290 EGFR inhibitor treatment induced changes in cell composition were determined by gene expression, ima

291 known immune function categories and immune cell compositions were investigated and compared among d

292 m NLP, whereas dermal tissue responses and T-cell compositions were similar to those in healthy skin.

293 ic inflammation; most immune changes were in cell composition, whereas transcriptional changes domina

294 ic infiltrates associated with a high plasma cell composition, which was different from the predomina

295 ith above median TMB, suggesting that immune cell composition, while correlated with TMB, may be a no

296 roduct composed of a defined ratio CD4:CD8 T-cell composition with a 4-1BB:zeta CAR targeting CD19 wh

297 were marked changes in BAL and interstitial-cell composition with increased number of polymorphonucl

298 Patients with sAH had the greatest change in cell composition, with increases in both periportal hepa

299 vels, which correlated with shifts in immune cell composition within specified tissue compartments.

300 nked to the spatial variations in the matrix cell composition within the thalamus.