ライフサイエンスコーパス: cell cycle protein

1 her functions have been associated with this cell cycle protein.

2 of the CCNE1 gene, which encodes cyclin E, a cell-cycle protein.

3 ar signal-regulated kinase and altered other cell cycle proteins.

4 by phosphorylating transcription factors and cell cycle proteins.

5 ites and cease to proliferate by influencing cell cycle proteins.

6 lator of the cell cycle, may be modulated by cell cycle proteins.

7 et MDSC population via downstream effects on cell cycle proteins.

8 d, disease-free controls for the presence of cell cycle proteins.

9 e cell cycle by mediating the degradation of cell cycle proteins.

10 duced mTORC1 signaling and altered levels of cell cycle proteins.

11 ne homologue B1, AKT, B-cell lymphoma 2, and cell cycle proteins.

12 requires activation of a defined pathway of cell cycle proteins.

13 e noncycling cells surprisingly express many cell cycle proteins.

14 hat modulates the expression and activity of cell cycle proteins.

15 s, such as changes in glycolytic enzymes and cell-cycle proteins.

16 human microRNAs (miRNAs) directly regulating cell-cycle proteins.

17 rned by the availability and activity of key cell-cycle proteins.

18 and decreased phosphorylation of G2-related cell-cycle proteins.

19 mediating ubiquitination and degradation of cell-cycle proteins.

20 largely derived from mitotic progression and cell-cycle proteins.

21 highlight the divergence of Symbiodiniaceae cell-cycle proteins across species.

22 The expression of cyclin D1 and downstream cell cycle proteins after partial hepatectomy was inhibi

23 ause any significant change in the levels of cell cycle proteins analyzed.

24 transcripts, as well a reduced abundance of cell cycle proteins, analyzed by quantitative, iterative

25 inoid anticancer compound, SHetA2, regulates cell cycle proteins and cell cycle progression in ovaria

26 mpounds had minimal effects on expression of cell cycle proteins and did not induce caveolin-1 in HCT

27 cell cycle control we examined expression of cell cycle proteins and growth of fibroblasts reversibly

28 d the correlation between C/EBPalpha levels, cell cycle proteins and hepatocyte proliferation in old

29 r plant and animal F-box proteins, including cell cycle proteins and hormone receptors.

30 to favor viral replication by dysregulating cell cycle proteins and kinases.

31 /- and E2f1+/- animals were found to express cell cycle proteins and replicate their DNA.

32 o investigate whether reactivation of the G1 cell cycle proteins and S phase entry was linked with ap

33 simplex virus scavenges the cell for useful cell cycle proteins and subverts them for its own use.

34 phages, suggesting a link between changes in cell cycle proteins and the presence of activated macrop

35 Dysregulated behavior of cell cycle proteins and their control by ubiquitin E3 li

36 f neurodegeneration involved reexpression of cell-cycle proteins and DNA synthesis, indicating that n

37 rentiated, non-cycling neutrophils repurpose cell-cycle proteins and pathways to form NETs.

38 facilitate robust and long-term depletion of cell-cycle proteins and reveals insights into the requir

39 its tumor suppressor function by regulating cell-cycle proteins and Six1 transcriptional targets c-m

40 Cell-cycle proteins and transcriptional regulators such

41 nts of 14 cell surface markers, 20 signaling/cell cycle proteins, and 6 transcription factors in ~300

42 C by lactate stimulates timed degradation of cell cycle proteins, and efficient mitotic exit in proli

43 st a possible cooperation of growth factors, cell cycle proteins, and transcription factors during th

44 and contains a motif found in ankyrins, some cell cycle proteins, and transcription factors.

45 lerated proliferation, altered expression of cell cycle proteins, and/or shortening of the G0/G1 cell

46 We show that several cell cycle proteins are expressed in different models of

47 gression and the regulated expression of key cell cycle proteins are independent of Jak3/common gamma

48 ion factors, which mediate the expression of cell cycle proteins as well as death-inducing genes.

49 trum of insulin resistance and points to the cell-cycle protein as a potential therapeutic target tha

50 ormed to evaluate the overexpression of this cell-cycle protein as one of the putative downstream eff

51 ells was evidenced by enhanced expression of cell cycle proteins, as determined by RT-PCR.

52 , the extent to which TOPgal cells coexpress cell cycle proteins, basic helix-loop-helix (bHLH) trans

53 Up-regulation of cell cycle proteins by EGF is blocked by inhibition of p

54 Additionally, DZIP3 regulated several cell cycle proteins by modulating the Cyclin D1-E2F axes

55 proliferating cell nuclear antigen (PCNA), a cell cycle protein, by immunohistochemistry.

56 Hence, human Speedy is a novel cell cycle protein capable of promoting cell proliferati

57 ion defect, as well as reduced levels of the cell cycle protein Cdc2.

58 lian protein that shows high homology to the cell cycle proteins Cdc20p of Saccharomyces cerevisiae a

59 The cell-cycle protein Cdc7 regulates S phase by promoting D

60 own leads to the down-regulation of the core cell cycle protein components (cyclins D1, E2, B1, and C

61 in Drosophila males, transcript for the core cell cycle protein Cyclin B1 (CycB) is expressed in sper

62 s associated with DNA damage, repair and the cell cycle protein Cyclin D1 in the contused brain sugge

63 to directly explore the significance of the cell cycle protein cyclin D2 in the expansion of beta-ce

64 tosis and markedly reduced expression of the cell cycle protein cyclin D2.

65 from G1 phase by decreasing the G1-specific cell cycle protein cyclin E and increasing the cyclin-Cd

66 al for maintaining optimum expression of the cell-cycle protein cyclin A for efficient cell-cycle pro

67 The human CCND1 gene, which encodes the cell-cycle protein cyclin D1, is one of the most frequen

68 zyme inhibitor protein (AZI), as well as the cell-cycle protein cyclin D1.

69 -regulated promoter of the gene encoding the cell-cycle protein cyclin E.

70 ation as well as expression of the late G1/S cell-cycle proteins cyclin E and cyclin-dependent kinase

71 3, Bax, MDM2, Gadd45), DNA repair (PCNA) and cell cycle proteins (cyclin A, cyclin D, cdk2, cdk4) in

72 ns in serum enzymes and the induction of key cell cycle proteins (cyclin D, cyclin E, and Stat3) and

73 air (p53, Bax, MDM2, WAF1, Gadd45, PCNA) and cell cycle protein, Cyclin D1, in male Wistar rats 48 h

74 eal a cell cycle-independent role for a core cell cycle protein, cyclin E, in synapse function and me

75 t data showing that BRCA1 ubiquitinates G2/M cell cycle proteins, cyclin B and Cdc25C, leading to the

76 gene promoter and levels of the AR-regulated cell cycle proteins, cyclin D1 and hyperphosphorylated R

77 ressed in primordial GC nuclei alongside the cell cycle proteins, cyclin D2 (CCND2) and P27.

78 arises from down-regulation of the essential cell-cycle proteins CyclinA, CKS1 and CDK1.

79 NA ligase I, NDH II, Topo I and Topo II) and cell cycle proteins (Cyclins A, B1, D1, D2, D3, E, CDK2,

80 nzyme inhibitors had no measurable effect on cell cycle protein degradation.

81 idual proteins showed that histones and some cell-cycle proteins do not scale with cell size.

82 3 ubiquitin ligase responsible for targeting cell cycle proteins during G1 phase.

83 potential role of Bmi1 as a key regulator of cell cycle proteins during neuronal apoptosis.

84 plication-coupled destruction of a cohort of cell cycle proteins ensures efficient and precise genome

85 transcription factor regulates expression of cell cycle proteins essential for hepatocyte entry into

86 we made a sequential study of alterations in cell cycle protein expression and complex formation amon

87 Rb in postmitotic neurons results in ectopic cell cycle protein expression and neuronal loss without

88 These data are consistent with cell cycle protein expression during podocyte maturation

89 current study was to identify differences in cell cycle protein expression in human and rabbit endoth

90 s demonstrated normal entry into S phase and cell cycle protein expression in the absence of essentia

91 indings demonstrated that MCL has a distinct cell cycle protein expression similar to that of high-gr

92 ive astrocytes from WT mice showed increased cell cycle protein expression that was significantly red

93 ventricular zone (VZ) through modulation of cell cycle protein expression, in particular cyclin D1 a

94 biquitin protein ligase complex that targets cell cycle proteins for degradation by the ubiquitin pro

95 15) show that these adaptors can also target cell cycle proteins for destruction through a second ubi

96 ession through the cell cycle by marking key cell cycle proteins for proteasomal turnover.

97 s an essential ubiquitin ligase that targets cell cycle proteins for proteasome-mediated degradation

98 tes cell cycle progression by ubiquitinating cell cycle proteins for proteolysis by the proteasome.

99 iscuss the potential of inhibiting different cell-cycle proteins for cancer therapy.

100 ex that targets nuclear p27 among many other cell-cycle proteins for proteosomal degradation.

101 les), were elucidated to identify changes in cell cycle protein function over different phylogenetic

102 gical tools and illustrate the redundancy of cell cycle protein function that can occur in cancer cel

103 velopment using reporters for MYC, MYCL, and cell cycle proteins Geminin and CDT1 in wild-type and va

104 Although several cell cycle proteins have been implicated in cell cycle-r

105 Previous reports describing manipulation of cell cycle proteins have not shown induction of cardiomy

106 onproliferative postmitotic roles that these cell cycle proteins have recently been reported to play,

107 ings reveal an unexpected function of a core cell cycle protein in DNA repair and suggest that target

108 regulation of HNF4alpha and cyclin D1, a key cell cycle protein in the liver.

109 ptotic effector of Abeta and of dysregulated cell cycle proteins in AD and identify both Bim and cell

110 poorly correlate with protein expression of cell cycle proteins in ALM or efficacy of CDK4i/6i, urgi

111 eries are normally linked, and expression of cell cycle proteins in developing T cells contributes to

112 ng as well as the expression and activity of cell cycle proteins in FGF2-stimulated intimal smooth mu

113 he expression levels of Cdk2 and its related cell cycle proteins in MCF-7 E cells showed that after E

114 hesion-growth factor control of these two G1 cell cycle proteins in melanomas.

115 Studies of cell cycle proteins in other models of neuronal death pr

116 suggests that inappropriate re-activation of cell cycle proteins in post-mitotic neurons may be respo

117 cytochemistry, we found the re-expression of cell cycle proteins in Purkinje cells and striatal neuro

118 tes distinct CARMA1-dependent control of key cell cycle proteins in T cells.

119 nase activity, cyclin E, cyclin A, and other cell cycle proteins in transgenic CD4(+)CD8(+) thymocyte

120 dentify several unexpected patterns for core cell-cycle proteins in actively proliferating (CDK2-incr

121 on to determine the temporal dynamics of key cell-cycle proteins in asynchronously cycling human cell

122 ese results reveal an unexpected function of cell-cycle proteins in controlling apoptosis in normal c

123 Cell-cycle proteins in cyclin D1(+) cells were not modul

124 creased expression and activation of various cell-cycle proteins in neuronal cell death.

125 To determine the role of cell-cycle proteins in regulating pathological renal hyp

126 Inappropriate activation of cell cycle proteins, in particular cyclin D/Cdk4, is imp

127 anges correlated with modulation of G1 phase cell cycle proteins including decreased cyclin D1, cycli

128 hich mediates the S-phase degradation of key cell cycle proteins, including Cdt1, PR-Set7, and p21.

129 evel and subcellular localization of several cell cycle proteins, including cyclin-D1, -E, -A, and -B

130 KFB3 increased the expression of several key cell cycle proteins, including cyclin-dependent kinase (

131 parallel, immunohistochemical assessment of cell cycle proteins, including cyclins A, B1, E, and Cdk

132 optosis, and altered the expression of other cell cycle proteins, including survivin and Aurora-A.

133 and the phosphorylation state of fundamental cell cycle proteins, including the retinoblastoma protei

134 sing proliferation by altering expression of cell cycle proteins, including up-regulation of p27(Kip1

135 Targeted disruption of various cell-cycle proteins, including Rb, p27(kip1) (p27), and

136 Cyclin D2 is the first cell cycle protein induced following stimulation through

137 he cell cycle inhibitor flavopiridol reduced cell cycle protein induction and significantly improved

138 Of the cell cycle proteins investigated, CDK2, CDK4 and CDK5 we

139 liferation in liver regeneration by inducing cell cycle proteins involved in mitotic progression, inc

140 trachomatis infection destabilizes specific cell cycle proteins involved in the G2/M transition.

141 ice, PHX induces robust up-regulation of key cell-cycle proteins involved in mitotic progression, inc

142 abnormal up-regulation of these important G1 cell cycle proteins is a relatively early event in intes

143 Proteolytic control of Caulobacter cell cycle proteins is primarily executed by ClpXP, a dy

144 cyclin D gene transcription, and accumulated cell cycle proteins known as calpain substrates.

145 atio on the activation threshold of critical cell cycle proteins, leading to the size-sensing checkpo

146 apalogs prevent cap-dependent translation of cell-cycle proteins like c-myc, continuing tumor cell gr

147 ne, and olomoucine) reduced up-regulation of cell cycle proteins, limited neuronal cell death after e

148 me2-dependent phosphorylation of a subset of cell-cycle proteins limits the effects of Cdc14 in meios

149 iew, we discuss our current knowledge of how cell cycle proteins mechanistically link cell proliferat

150 n interactions, reproduction, DNA metabolism/cell cycle, protein metabolism, and neuronal function.

151 mechanisms, and modulate the dynamics of the cell cycle protein network.

152 ns is required in vivo for the modulation of cell cycle proteins observed in cells infected with wild

153 Since changes in other cell cycle proteins occur at a later time during TGFbeta

154 These findings suggest that changes in cell cycle proteins occur in both HIVE and the simian mo

155 At least one major control point for the cell cycle proteins occurred between "start" and early S

156 Up-regulation of cell cycle proteins occurs in both neurons and glia afte

157 Cdc25C is a cell cycle protein of the dual specificity phosphatase f

158 sor cells which bears affinity for the yeast cell cycle protein p13sucl and which undergoes rapid tyr

159 of caspase-3 and affecting the expression of cell cycle proteins p21 and CDK2.

160 imulate expression of the TGF-beta-regulated cell cycle protein p27 in the HP75 human pituitary adeno

161 Increased association of cell-cycle proteins p27(kip) and cyclin-dependent kinase

162 regulate expression of the gene encoding the cell cycle protein p55Cdc by using cDNA array technique.

163 of ligand activation on cell proliferation, cell cycle protein phosphorylation, and capillary tube f

164 d INS1 cells display striking differences in cell cycle protein profiles; 3) phosphorylation of pRb i

165 Cell cycle proteins regulate processes as diverse as cel

166 Recent studies revealed that cell-cycle proteins regulate a wide range of cellular fu

167 s25/-)mice; and expression of Cdc25A and the cell-cycle proteins regulated by Cdc25A.

168 crucial biological processes (BPs), such as cell cycle, protein regulation and inflammation.

169 f the p27 CDK inhibitor, and other G1-acting cell cycle proteins, remained unaffected.

170 Analysis of some critical cell cycle proteins revealed a specific increase in expr

171 The analysis of critical E2- and TAM-related cell cycle proteins revealed an increase of both the exp

172 Instead, immunohistochemical quantitation of cell cycle proteins reveals that MKK4-expressing cells f

173 Cell cycle proteins showed an increased expression 24 ho

174 Analysis of several cell cycle proteins shows normal down-regulation of p27

175 Reexpression of cell cycle proteins such as cyclin-dependent kinases (CD

176 division relies on the timely removal of key cell cycle proteins such as securin.

177 pirates and repurposes well-known bacterial cell cycle proteins, such as FtsZ, FtsA, PopZ, and PodJ.

178 ories including regulation of transcription, cell cycle, protein synthesis, and apoptosis.

179 rts showed increased levels of RNAs encoding cell-cycle proteins, Tgf-beta, periostin, and other prof

180 es, we identify Bora as a previously unknown cell cycle protein that interacts with the Plk1 kinase a

181 nal role of p53 in the regulation of PRC1, a cell cycle protein that plays important roles during cyt

182 nucleotides (ONs) targeted against two human cell cycle proteins that are aberrantly expressed in bre

183 Cell cycle proteins that are often dysregulated in malig

184 Besides adding CDK7 to the expanding list of cell cycle proteins that impinge on immune regulation, t

185 We identify distinct sets of cell cycle proteins that specifically associate with dif

186 tara encodes a conserved cell-cycle protein that contains a Cyclin A (CycA)-bindi

187 Geminin is an essential cell-cycle protein that is only present from S phase to

188 The Atm and Atr proteins are mitotic cell-cycle proteins that also associate with chromatin d

189 These effects were accompanied by changes in cell-cycle proteins that suggest possible mechanisms for

190 in the regulation of the expression of this cell cycle protein, the methylation patterns of p27 in n

191 cle progression through direct regulation of cell cycle proteins, through nutrient-sensing signaling

192 Herpesviruses are known to interact with cell cycle proteins; thus, the antiviral effects of Rosc

193 Such modular architecture is common among cell-cycle proteins; thus, the WW-PPIase domain cross-ta

194 uses often modulate the function of critical cell cycle proteins to maximize the efficiency of virus

195 factor couples the coordinate expression of cell cycle proteins to their appropriate transition poin

196 lpha-factor and hydroxyurea, we assigned the cell cycle proteins to two classes: proteins in class I

197 ubiquitin-dependent proteolysis of specific cell-cycle proteins to coordinate chromosome segregation

198 SCI caused cell cycle protein up-regulation associated with neurona

199 a potential pathway involved, expression of cell cycle proteins was assessed.

200 emokines, inflammatory, stress response, and cell cycle proteins was evident in wild-type mice.

201 the effect of E2F97 on expression of various cell cycle proteins was examined.

202 The effect of activated human K-ras on cell cycle proteins was studied by use of a stable MCF-7

203 Association of Cdc42 with cell-cycle proteins was identified by immunoprecipitatio

204 he AKT client molecule p27kip, an inhibitory cell cycle protein, was reduced, whereas cyclin E, which

205 equences of acute and chronic elimination of cell-cycle proteins, we generated and characterized indu

206 Although we found that Crk II bound to the cell cycle protein Wee1, expression of GFP-Crk-nuc did n

207 ut or with RAPA (10 ng/ml) and G1-associated cell cycle proteins were analyzed by immunoblot and dens

208 (ATRA) on cell proliferation, apoptosis, and cell cycle proteins were examined in SEB-1 sebocytes and

209 DNA repair proteins and cell cycle proteins were preferentially expressed within

210 low cytometry, and analysis of signaling and cell-cycle proteins were established.

211 pho-Bad (Ser112) and histone H3 (Ser10), and cell-cycle proteins were unaffected by SGI-1776, suggest

212 Plk1 (Polo-like kinase 1) and other M-phase cell-cycle proteins, which may underlie AI PCa growth.

213 hat ultimately converge on the regulation of cell cycle proteins whose expression and activity are ab

214 e was progressive loss of expression of both cell cycle proteins with increasing tumor grade and path