ライフサイエンスコーパス: cell cycle regulator

1 CMV replication by targeting Cdc25a, a vital cell cycle regulator.

2 and anaphase-promoting complex (APC), a key cell cycle regulator.

3 ents are required to fully activate this key cell cycle regulator.

4 esis may be independent of its function as a cell cycle regulator.

5 hese studies identified KDM8 as an important cell cycle regulator.

6 that express small amounts of this essential cell cycle regulator.

7 re instead caused by aggregation of the Whi3 cell cycle regulator.

8 The E2F transcription factor is a key cell cycle regulator.

9 p between a connexin molecule and a critical cell-cycle regulator.

10 cells [LSCs]) that exceeds its function as a cell-cycle regulator.

11 E2 Factor 1 (E2F-1) and E2 Factor 4 (E2F-4) cell cycle regulators.

12 ed by the up-regulation of numerous positive cell cycle regulators.

13 trated deregulated expression of a number of cell cycle regulators.

14 se by promoting the degradation of important cell cycle regulators.

15 R-mediated induction of c-Myc and additional cell cycle regulators.

16 , including many cytoskeletal components and cell cycle regulators.

17 xpression of regenerative growth factors and cell cycle regulators.

18 of MALAT1 impaired the expression of various cell cycle regulators.

19 ific degradation beyond degradation of known cell cycle regulators.

20 translation of other ribosomal proteins and cell cycle regulators.

21 , cell cycle distribution, and expression of cell cycle regulators.

22 cle progression through its interaction with cell cycle regulators.

23 which have not been previously described as cell cycle regulators.

24 loid divisions, despite normal expression of cell cycle regulators.

25 coordinated activity of differentiation and cell cycle regulators.

26 intrinsic signaling pathways, microRNAs, and cell cycle regulators.

27 rolling the temporal degradation of specific cell cycle regulators.

28 clei define such pacemakers by concentrating cell cycle regulators.

29 equired signalling events for the control of cell cycle regulators.

30 cell cycle by coordinating the activities of cell-cycle regulators.

31 g up-regulation of both the p21 and p19(ARF) cell-cycle regulators.

32 by controlling the transcription of multiple cell-cycle regulators.

33 methyltransferase CcrM is one of five master cell-cycle regulators.

34 er cells through the upregulation of several cell-cycle regulators.

35 factor contributing to efficient splicing of cell-cycle regulators.

36 transcriptional repression of genes encoding cell-cycle regulators.

37 endent manner, stimulating expression of the cell-cycle regulator AIL1 and suppressing BRANCHED1 expr

38 This study demonstrates that canonical cell-cycle regulators also play important noncanonical r

39 logy analysis highlighted a preponderance of cell cycle regulators among the 1121 genes perturbed upo

40 Response gene to complement (RGC)-32 is a cell cycle regulator and a downstream target of TGF-beta

41 Despite its well-documented role as a cell cycle regulator and as a tumor suppressor, the func

42 -21 while increasing the levels of Cdc25a, a cell cycle regulator and known target of miR-21.

43 oblastoma tumor suppressor (RB) is a central cell cycle regulator and tumor suppressor.

44 Y chromosome and its X-homologue, TSPX, are cell cycle regulators and function as a proto-oncogene a

45 s, transcription factors, chromatin factors, cell cycle regulators and growth factors.

46 ng, but is accompanied by alterations in key cell cycle regulators and is linked to an hTERT-catalyze

47 t stimulates proliferation and expression of cell cycle regulators and stemness-associated genes, but

48 KDM5-activated genes include a large set of cell cycle regulators and that the KDM5s are necessary f

49 le interactions of HCV-encoded proteins with cell cycle regulators and tumor suppressor proteins, rai

50 ctions between HCV-encoded proteins and host cell cycle regulators and tumor suppressor proteins, the

51 e enriched with transcription factors and/or cell cycle regulators and were unrelated to duration of

52 cally, we show that VentX regulates critical cell cycle regulators and Wnt downstream genes previousl

53 CTGF treatment upregulates positive cell-cycle regulators and factors involved in beta-cell

54 e a novel mechanistic role for HIRA (histone cell cycle regulator) and proteasomal degradation-associ

55 l role and mechanism for FOXD3 as a negative cell cycle regulator, and have implications for the repr

56 the cyclin-dependent kinase (Cdk1), a major cell cycle regulator, and the metabolic regulator protei

57 APC substrates are typically cell cycle regulators, and consistent with this, the los

58 regulated transcripts, including several key cell cycle regulators, and genes involved in motility, a

59 cation are Wnt/beta-catenin pathway members, cell cycle regulators, and genes required for mitotic sp

60 in the essentiality of divJ and divK spatial cell cycle regulators, and non-essentiality of the highl

61 actors (including Tcf7), effector molecules, cell cycle regulators, and proteins that regulate fatty

62 eristems by activating the expression of key cell cycle regulators, and therefore, promoting G2 to M

63 p63 regulates the expression of cell cycle regulators, and we determined that cyclin A,

64 al components, AHSP, heme synthesis enzymes, cell-cycle regulators, and blood group antigens.

65 genes encoding DNA-damage response factors, cell-cycle regulators, and chemokine receptors.

66 ription factors, impairment of the CDKN2A/2B cell-cycle regulators, and hyperactive NOTCH1 signaling

67 xplaining persistence, such as activation of cell cycle regulators, anti-apoptotic stimuli, metabolic

68 Furthermore, genomic profiling shows that cell cycle regulators are altered in the majority of EGF

69 We discovered that cell cycle regulators are expressed hours before the act

70 ontrol of cellular proliferation and cancer, cell cycle regulators are increasingly identified as imp

71 ercle; however, transcriptional levels of G1 cell cycle regulators are reduced.

72 and colorectal cancer risk by the status of cell-cycle regulators are lacking.

73 and -2, either alone or in combination with cell cycle regulators, are recruited near the DSB, where

74 cer and activator of transcription 3 and the cell cycle regulator aryl hydrocarbon receptor, the data

75 interacts with Hsp90, implicating this major cell cycle regulator as a novel Hsp90 client protein in

76 ative PCR array analyses identified multiple cell cycle regulators as potential ZNF24 downstream targ

77 ce, we detected a reduction in proliferative cell cycle regulators as well as an increase in the cell

78 tify bHLH/homeobox transcription factors and cell-cycle regulators as key genes mediating BETi's resp

79 with mammalian apoptosis the involvement of cell-cycle regulators as signaling components.

80 s preferentially modulate expression of host cell cycle regulators, as well as antiviral response fac

81 rest, and that differences in the balance of cell cycle regulators between 129/SvJ and C57BL/6 might

82 ack of protein expression of the key meiotic cell cycle regulators Boule and Cyclin B.

83 ly, flavopiridol inhibited mRNAs of multiple cell cycle regulators, but with uniform increases in bcl

84 -dependent kinase inhibitor 2a) are critical cell-cycle regulators, but their roles in human cardiomy

85 NQO1 expression attenuated the reduction of cell cycle regulators by 17-AAG treatment in AhR overexp

86 the expressions of markers of DNA damage and cell-cycle regulators by immunoblotting and performed si

87 itin ligase that promotes the degradation of cell-cycle regulators by the 26S proteasome.

88 it, induces transcriptional up-regulation of cell cycle regulators, bypasses the need for S-phase cel

89 red biphasic regulation of expression of the cell-cycle regulator c-Myc that involved its transient i

90 nd, ultimately, proliferation induced by the cell-cycle regulator c-Myc.

91 ssociation: that increased expression of the cell-cycle regulator C/EBPdelta decreases sensitivity to

92 es cellular SCF(Fbw7) targets, including the cell-cycle regulators c-Myc and cyclin E.

93 sis factors (MCL-1, PTTG1, and survivin) and cell-cycle regulators (c-Myc).

94 on using a breast cancer model in which this cell-cycle regulator can be genetically ablated prior to

95 This dominantly acting cell cycle regulator causes mitotic arrest and, thereby,

96 evels, increased Tnf expression, decreased a cell cycle regulator (Ccnb1), and increased apoptotic fa

97 target was Ccnd1 mRNA, which encodes the key cell cycle regulator CCND1 (Cyclin D1).

98 ion of oncogenes FOS, JUN, NFKB, and MYC and cell cycle regulators CCND1, CCNE1, and CDK4/6, along wi

99 by altered expression of the c-Myc-targeted cell cycle regulators CCND1, CDKN1A and CDKN2D in a time

100 rk that is responsible for activation of the cell-cycle regulator Cdc14p in Saccharomyces cerevisiae.

101 iR-424(322)/503 reduce the expression of the cell cycle regulator CDC25A.

102 e insulin receptor substrate (IRS)-2 and the cell-cycle regulator CDC25b.

103 sis is coordinately controlled by the master cell cycle regulator Cdk together with its counteracting

104 morphogenesis checkpoint regulator, and the cell cycle regulator Cdk1 play key roles in these morpho

105 CYC6 is a functional homologue of the major cell cycle regulator CDK1, yet definitive genetic eviden

106 denocarcinoma cells, and downregulates a key cell cycle regulator, CDK2.

107 ts tumor-suppressive activities by targeting cell cycle regulators CDK4/6 and anti-apoptotic factor B

108 ly expanded by conditional expression of the cell cycle regulators Cdk4/cyclinD1, thus increasing neu

109 is issue of Blood, Placke et al identify the cell-cycle regulator CDK6 as a promising new target in m

110 by MLL-AF9 are exceptionally reliant on the cell-cycle regulator CDK6, but not its functional homolo

111 ates at specific enhancer regions of the key cell cycle regulator Cdkn1a and the stem cell regulator

112 of Notch2, there were elevated levels of the cell cycle regulators Cdkn1a (p21Cip1), Ccnd2 (CyclinD2)

113 osttranslational modification of the central cell-cycle regulators CDKN1A, retinoblastoma protein, an

114 s of chromosome 9p21 are known to target the cell cycle regulators CDKN2A and CDKN2B.

115 ly through up-regulation of the let-7 target cell cycle regulators cell division cycle 34 (Cdc34) and

116 Unexpectedly, most classic cell-cycle regulators conserved in T. gondii were not de

117 n lead to tumor development and suggest that cell cycle regulators could be effective targets in anti

118 -controlled and co-conserved with the global cell cycle regulator CtrA in the alpha-proteobacteria.

119 ly in other Rhizobiaceae species, the master cell cycle regulator CtrA may recognize an expanded moti

120 ycle progression, and also act on the master cell cycle regulator CtrA.

121 eipA, is directly activated by the essential cell cycle regulator, CtrA.

122 s retraction stimulates the synthesis of the cell-cycle regulator cyclic diguanylate monophosphate (c

123 lerosis through, at least in part, targeting cell cycle regulator cyclin A and connective tissue grow

124 Increased nuclear Yap and the cell cycle regulator cyclin D1 accompanied cardiomyocyte

125 Cyclin D1b is a splice variant of the cell cycle regulator cyclin D1 and is known to harbor di

126 anied by increases in mRNA expression of the cell cycle regulator cyclin D1 and/or glioma-associated

127 the diminution of Ccnd1 encoding the crucial cell cycle regulator cyclin D1 in the dental epithelium.

128 tination and degradation of the prooncogenic cell cycle regulator cyclin D1, and also down-regulates

129 f Sox2-positive cells may be mediated by the cell cycle regulator cyclin D1.

130 argeting the stem cell regulator TLX and the cell cycle regulator cyclin D1.

131 Further, when the cell cycle regulator Cyclin D2 is missing, cell cycle le

132 ST6Gal-I also potentiates expression of the cell cycle regulator cyclin D2, leading to increased pho

133 hesis is repressed by disruption of the core cell cycle regulator CYCLIN-DEPENDENT KINASE A;1 (CDKA;1

134 Cell cycle regulators cyclin D1 and cyclin D2 were decre

135 1 stimulation, resulting in induction of the cell cycle regulators cyclin D1 and p21(WAF1/CIP1) PREX1

136 filing and functional studies identified the cell cycle regulators cyclin D1 and USP44 as primary KLF

137 Here, we demonstrate that cell cycle regulators Cyclin D1-3 control cell fate deci

138 TLR4 increased the nuclear abundance of the cell cycle regulators cyclin D2 and Cdk4 in a manner dep

139 pal wing enhancers for the key rate-limiting cell cycle regulators Cyclin E (cycE), E2F transcription

140 dition of a nondegradable form of the master cell-cycle regulator cyclin B1 can indeed induce some bi

141 ed with high-risk neuroblastoma, such as the cell-cycle regulator cyclin B1-interacting protein 1 (Cc

142 describe 2 modes of SOX11 regulation by the cell-cycle regulator cyclin D1 (CCND1) and the signal tr

143 The cell-cycle regulator cyclin D1 is expressed in the liver

144 ocytic differentiation via regulation of the cell-cycle regulator cyclin D1.

145 These mechanisms are governed by the cell-cycle regulators cyclin D1-3 that control different

146 ction of transcription factors (OCT4 and T), cell cycle regulators (cyclin D family members) and epig

147 Here, we show that the cell cycle regulator, cyclin-dependent kinase 2 (CDK2),

148 udy, we describe an evolutionarily conserved cell-cycle regulator, cyclin-dependent kinase inhibitor

149 Here, we show that the master cell-cycle regulators, cyclin-dependent kinase (Cdk) and

150 y the timing of gene expression for critical cell cycle regulators cyclins D, A2, and B2 and cyclin-d

151 ted by CcrM and co-regulated by other global cell cycle regulators, demonstrating an extensive cross

152 Taken together, our findings reveal that cell cycle regulators direct mesoderm formation by contr

153 hat the F-box protein FBL17 acts as a master cell cycle regulator during the diploid sporophyte phase

154 that ensures the faithful ubiquitination of cell cycle regulators during mitosis.

155 of the cell cycle and reduced expression of cell cycle regulators during the initiation stage of rep

156 We show that differential expression of cell-cycle regulators during development may be responsi

157 e proteasome, thereby driving degradation of cell-cycle regulators during early mitosis.

158 ase (CDK) inhibitor 1A, p21/Cip1, is a vital cell cycle regulator, dysregulation of which has been as

159 its central role in the degradation of many cell-cycle regulators, e.g., Cdt1, p21, and Pr-Set7/Set8

160 egulatory elements targeted by the ancestral cell cycle regulator E2F, much like extant viral oncogen

161 CPR5 to cause overactivation of another core cell-cycle regulator, E2F.

162 The cell cycle regulators E2F1, MYC, MYBL2 (B-Myb) and FOXM1

163 predicted miR-31 gene targets including the cell cycle regulator E2F2.

164 rgeting the pluripotency factor Sox2 and the cell-cycle regulator E2F3 in neural stem/progenitor cell

165 NC and MCI associate differentially with the cell-cycle regulators E2F4 and E2F5, which enables them

166 acting through CK and the CK-inducible CYCD3 cell cycle regulators, establishing a mechanistic link t

167 ic exit and G1/S transition by targeting key cell-cycle regulators for destruction.

168 tes mitosis and G1 by sequentially targeting cell-cycle regulators for ubiquitination and proteasomal

169 ed a role for FOXM1 and identified two novel cell cycle regulators, FOXJ3 and FOXK1.

170 Here, we found that the essential cell cycle regulator GcrA in Caulobacter crescentus acti

171 e of the Hox homeodomain in complex with the cell-cycle regulator, Geminin, which inhibits Hox transc

172 genomic network connecting loci enriched in cell cycle regulator genes to nuclear lamina that mediat

173 that ClpXP and Lon each degrade an important cell cycle regulator, helping to trigger the onset of S

174 timing of Yen1 activation, governed by core cell-cycle regulators, helps coordinate DNA repair with

175 The human histone cell cycle regulator (HIRA) complex composed of HIRA, ub

176 haperone HIRA complex, consisting of histone cell cycle regulator (HIRA), Ubinuclein1 (UBN1), and cal

177 acts as a protease in the maturation of the cell cycle regulator host cell factor 1 (HCF-1) and serv

178 GlcNAc transferase not only glycosylates the cell-cycle regulator host cell factor 1 but activates it

179 ly impacted by proteolytic activation of the cell cycle regulator, host cell factor-1.

180 of Ajuba controls the expression of multiple cell cycle regulators; however, it does not affect Hippo

181 Whereas many established cell-cycle regulators impact NPC proliferation, other si

182 Polo-like kinase 1 (PLK1) is a key cell cycle regulator implicated in the development of va

183 tion factor specificity protein 2 (Sp2) as a cell cycle regulator in two temporally and spatially dis

184 tly, expression of the Gonium retinoblastoma cell cycle regulator in unicellular Chlamydomonas causes

185 eomics profiles reveal a deregulation of key cell cycle regulators in lincNMR-depleted cells like the

186 eficient mice and analyzed the expression of cell cycle regulators in liver samples taken at differen

187 ish this feat, viruses often target critical cell cycle regulators in order to have maximal effect wi

188 However, genetic manipulation of cell cycle regulators in the germ lines of mice results

189 ections between the extracellular matrix and cell cycle regulators in the regulation of hematopoiesis

190 nalysis of the Polo-like kinase (Plk) family cell-cycle regulators in mice, we show that Plk1's expre

191 systematically isolate and annotate the core cell-cycle regulators in the moth orchid Phalaenopsis ap

192 ar regulation and functional significance of cell-cycle regulators in the pathogenesis and developmen

193 e the retinoblastoma protein (Rb), a crucial cell cycle regulator, in two subtypes of postmitotic SCs

194 However, the role of c-Myc, a key cell-cycle regulator, in this process has been questione

195 ndance and alternative splicing of important cell cycle regulators including CYCLIN-D2, c-MYC, p107 a

196 Therefore, like many critical cell cycle regulators including p21 and Cdt1, we uncover

197 cs1 facilitates transcriptional silencing of cell cycle regulators including RB/E2F target genes, lik

198 In addition, miR-31 suppressed cell-cycle regulators including E2F1, E2F2, EXO1, FOXM1,

199 ed to suppress the expression of several key cell-cycle regulators including E2F2, and chromatin immu

200 oliferation through regulating expression of cell cycle regulators (including CCND1, CCND2, and ID2)

201 Cell cycle regulators, including cyclin D1 and survivin,

202 Combinations of cell cycle regulators, including E2f1 and CyclinD, delay

203 accompanied by reduced expression of several cell cycle regulators, including Mad2.

204 Expression of critical cell-cycle regulators, including ctrA, and cell division

205 this happens in a manner independent of the cell-cycle regulators Ink4a and Arf, which play a major

206 The 14-3-3sigma (Stratifin; Sfn) is a cell cycle regulator intimately involved in the program

207 In particular, disruption of the CDKN2A/B cell cycle regulator is associated with approximately 30

208 for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells

209 The compartmentalization of cell cycle regulators is a common mechanism to ensure th

210 Increasing evidence suggests that Plk1, a cell cycle regulator, is also involved in cellular event

211 It is likely that p53, a well-known cell cycle regulator, is involved in regulating the gene

212 Cut, a linker between Notch signaling and cell-cycle regulators, is specifically downregulated by

213 Vasculature proliferation also involves the cell cycle regulator KIP-RELATED PROTEIN2 and ABERRANT L

214 The cell cycle regulator KRP6 partially represses GA-depende

215 with MLL-rearranged AML, and underscore that cell-cycle regulators may have distinct, noncanonical, a

216 Cell cycle regulators, most notably Cdkn2a, were upregul

217 Here we show that CYREN (cell cycle regulator of NHEJ) is a cell-cycle-specific i

218 decrease in the expression of several known cell cycle regulators of HSCs, among which Cdkn1a and Eg

219 2-associated Protein 1 (CDK2AP1) is one such cell-cycle regulator, originally identified as a growth

220 wth control, including the repression of the cell cycle regulators p14 and p21.

221 the CDKN2A and CDKN2B genes which encode the cell cycle regulators p16(INK4a), p14(ARF) and p15(INK4b

222 aining limited transcription of the negative cell cycle regulators p16Ink4a and p19Arf from the Cdkn2

223 n the transcription factor E47 and the major cell cycle regulator p21 in controlling LT-HSC integrity

224 o MutSbeta, an effect that is blocked by the cell cycle regulator p21(CIP1).

225 ased expression of CDKN1A, which encodes the cell cycle regulator p21(WAF1), as well as the pro-apopt

226 hway and inhibition of the expression of the cell cycle regulator p21.

227 ed proliferation and increased levels of the cell cycle regulator p21/WAF/CDKN1A and disrupts TGF-bet

228 s, suppressing p53-induced expression of the cell-cycle regulator p21 and enhancing p53-induced up-re

229 Here, we report that overexpression of the cell-cycle regulator p21 is a critical feature of liver

230 lpha, the translation regulator HuR, and the cell-cycle regulators p21 and survivin.

231 betaMHC) mRNA was increased whereas negative cell-cycle regulators (p21, Meis1) were decreased in Tbx

232 Here, we exploited the cell cycle regulator p27(Kip1) (p27) as a model system t

233 Our studies ascribe a novel role for the cell cycle regulator p27(Kip1) as a prominent negative r

234 cent computational and experimental study of cell-cycle regulator p27 demonstrated that long-range el

235 ll-related genes and pathways, including the cell-cycle regulator p27, are lower in parous women with

236 plete silencing of Cdkn1c, encoding negative cell-cycle regulator p57-Kip2.

237 ion by regulating expression and activity of cell cycle regulators, particularly at the G1/S checkpoi

238 Yata et al. show that the mitotic kinase and cell-cycle regulator Plk1 can directly stimulate the DNA

239 In addition, we revealed that a cell cycle regulator, Plk1, switches the balance between

240 oints in the cell cycle, including important cell cycle regulators, plus factors involved in signal t

241 es previously associated with LCH, including cell-cycle regulators, proinflammatory cytokines, and ch

242 Hdac1/2 leads to increased expression of the cell-cycle regulators Rb1, p21/Cdkn1a, and p16/Ink4a, re

243 The retinoblastoma (pRB) family of cell cycle regulators, Rb1, Rbl1 (p107), and Rbl2 (p130)

244 by RNAi can mimic the effect of GPC1 on the cell cycle regulators related to the loop.

245 ion represses expression of proproliferative cell cycle regulators required for DNA replication and D

246 zation and downstream phosphorylation of the cell cycle regulator retinoblastoma protein (Rb).

247 Analysis of cell-cycle regulators revealed that autophagy inhibition

248 and UAS4 also contain binding sites for the cell cycle regulator SBF (an Swi4-Swi6 heterodimer), whi

249 Here, we show that another critical cell cycle regulator, SciP, is also degraded during the

250 sential process, some core animal and fungal cell cycle regulators share no more sequence identity th

251 inetics, telomere lengths, and expression of cell cycle regulators showed significant variation betwe

252 erentiation through its interaction with the cell cycle regulator Stratifin.

253 Thus, like other cell cycle regulators such as Aurkb and survivin, Aurka

254 Cell-size-dependent accumulation of limiting cell cycle regulators such as CDKG1 is a potentially gen

255 cription of AP-1-element containing G1-phase cell cycle regulators such as Myc and Ccnd1 to promote N

256 ression had significant effects on classical cell cycle regulators such as p21/WAF1 or retinoblastoma

257 is occurs without the apparent activation of cell-cycle regulators such as polo kinase or the septati

258 of DNA safeguard mechanisms by targeting of cell-cycle regulators such as WEE1.

259 is implicated in the degradation of several cell cycle regulators, such as p21(Cip1), p27(Kip1), p57

260 variability of essentiality was observed in cell cycle regulators, suggesting regulatory mechanisms

261 e otherwise highly conserved fizzy family of cell-cycle regulators, suggesting that it probably regul

262 apoptosis and vitamin metabolic pathways and cell cycle regulators, suggestive of loss of cellular ho

263 We propose that cell-cycle regulators target TTBK2 to the basal body, wh

264 intricate gene regulatory network involving cell-cycle regulators, TGFbeta effectors and oncogenic m

265 We propose that Mad2 is an important meiotic cell cycle regulator that ensures the timely degradation

266 Thus, our study suggests PPP1R3B as a new cell cycle regulator that functions by governing Gwl dep

267 th an increased expression of p21cip1/waf, a cell cycle regulator that is involved in the differentia

268 Cdc5/Polo kinase is an important upstream cell cycle regulator that suppresses Cdc42 activity.

269 dt2 (CRL4(Cdt2)) is emerging as an important cell cycle regulator that targets numerous proteins for

270 derstanding the functional roles of multiple cell cycle regulators that drive plasticity and sensitiv

271 mediator complex, cohesin-related genes, and cell cycle regulators that induce S phase.

272 Schlafen (SLFN) family of genes, a group of cell cycle regulators that mediate growth-inhibitory res

273 Polo-like kinase 1 (PLK1) is an essential cell-cycle regulator that is frequently overexpressed in

274 Rb1 encodes a cell-cycle regulator that is functionally disrupted in m

275 e Plasmodium-specific kinase PfCRK4 is a key cell-cycle regulator that orchestrates multiple rounds o

276 ct in the nucleus via repression of 2 potent cell-cycle regulators that are encoded by the Ink4a/Arf

277 egeneration by controlling the expression of cell-cycle regulators that drive M phase progression.

278 es a mechanism for the selective disposal of cell-cycle regulators that have fulfilled their mitotic

279 yclin-dependent kinases (CDKs) are the major cell-cycle regulators that phosphorylate hundreds of sub

280 ore, suppressor analysis showed that another cell cycle regulator, the methyltransferase CcrM, is sim

281 intermediates, signal transduction pathways, cell cycle regulators, the organelle/protein recycling m

282 -independent developmental role for a master cell-cycle regulator, the anaphase-promoting complex or

283 each centrality ranking contained well-known cell cycle regulators, there was little agreement and no

284 dering the important role of p19(ink4d) as a cell cycle regulator, these results provide evidence for

285 ce of the unique capacity of APC/C and other cell cycle regulators to couple distinct cellular proces

286 ich controls cell division by ubiquitinating cell cycle regulators to drive their timely degradation.

287 modeling complex that collaborates with core cell-cycle regulators to promote cell-cycle exit and ter

288 translational suppression of mRNAs encoding cell-cycle regulators via the mTORC1/eukaryotic translat

289 In OVCAR3, an induction of cell cycle regulators was further shown.

290 Based on its role as a cell cycle regulator, we predicted that an Aurka deficie

291 r4a1, Gata2, Junb and Btg2, and the positive cell cycle regulators were correspondingly down-regulate

292 Protein and transcript levels of cell cycle regulators were examined in breast cancer cel

293 Cyclin E is a cell cycle regulator which is critical for driving G1/S

294 ly transcribed genes, including Myc and Pim1 cell-cycle regulators, which associate with an entirely

295 Z/YAP promote SC proliferation by activating cell cycle regulators, while targeting critical differen

296 E.g., all species lost the cell-cycle regulator WHIskey 5 (WHI5), and the FEL lost

297 They also identify ASC-1 as a novel cell cycle regulator with a key role in cell proliferati

298 murine leukemia identified reprogramming of cell cycle regulators with decreased SP1 and increased p

299 Posttranslational modification of cell-cycle regulators with ubiquitin chains is essential

300 ession of a large number of genes, including cell cycle regulators, with concomitant increased cellul