ライフサイエンスコーパス: cell depletion

1 nd a failure of disease to recur after CD3 T cell depletion.

2 enewal capacity, myeloid skewing, and immune cell depletion.

3 gm function was also unaffected by satellite cell depletion.

4 ion was suppressed by plasmacytoid dendritic cell depletion.

5 ation of the inflammasome resulting in CD4 T cell depletion.

6 to achieve simultaneous DC expansion and NK cell depletion.

7 macaques for years after sustained memory B cell depletion.

8 of B cells and investigated mechanisms of B-cell depletion.

9 ators, consequently slowing down muscle stem cell depletion.

10 mportance of abortive infection in driving T cell depletion.

11 ystrophic phenotype due to rapid muscle stem cell depletion.

12 s of cGVHD, they increased after anti-CD20 B-cell depletion.

13 ed with HBV after antibody-mediated CD4(+) T-cell depletion.

14 d were largely refractory to systemic immune cell depletion.

15 ecropsy, and no virus emerged after CD8(+) T cell depletion.

16 ongoing EAE, which was abrogated by CD8(+) T cell depletion.

17 dampening of autoimmune processes through B cell depletion.

18 , and 28 d postinfection even after CD4(+) T cell depletion.

19 ion, chronic immune activation, and CD4(+) T cell depletion.

20 tissue (LT) fibrosis, which causes CD4(+) T-cell depletion.

21 o AA rupture, which was attenuated by CD8+ T cell depletion.

22 t these B cells are resistant to alphaCD20 B-cell depletion.

23 n largely manifests itself in vivo as CD4+ T cell depletion.

24 lls forming hepatic metastases after myeloid cell depletion.

25 fibroblasts, all of which were reduced by B cell depletion.

26 ccessfully treated with anti-CD20-mediated B-cell depletion.

27 rmline defects such as hypogonadism and germ cell depletion.

28 than F1 cells was reduced by natural killer-cell depletion.

29 ed B cell recovery after antibody-mediated B cell depletion.

30 y up-regulated in cancer cells after myeloid cell depletion.

31 nor (D-) transplants and is exacerbated by T-cell depletion.

32 erived from studies of patients treated by B-cell depletion.

33 with chronic immune activation and CD4(+) T cell depletion.

34 of the early steps of HIV-1 infection and T cell depletion.

35 r concerted effect in inducing resting CD4 T cell depletion.

36 te of ongoing viral replication and CD4(+) T cell depletion.

37 ative states and no evidence of regulatory T cell depletion.

38 mmunotherapy approach for antigen-specific B cell depletion.

39 ansplanted mice in the absence of systemic T cell depletion.

40 ulted in acute, resolving viremia and CD4+ T-cell depletion.

41 versatile therapeutic modality for targeted cell depletion.

42 of these, 129 (64.5%) received an in vivo T-cell depletion.

43 iral infections due to combined T cell and B cell depletion.

44 Specific natural killer cell depletion 24 hours pre-acute myocardial infarction

45 in the monkey with the most extensive CD4 T cell depletion (5%) and in all other monkeys at 10 to 49

46 stinal atrophy featuring stem and progenitor cell depletion, a phenotype unexpected from the previous

47 bers of effector T cells in the tumor, and T cell depletion abolished the reduced tumor growth observ

48 Recipient B cell depletion abrogated early macrophage recruitment, s

49 Total T-cell or selective regulatory T-cell depletion abrogates the atheroprotective effect of

50 d and brain tissue was attenuated by myeloid cell depletion after TBI.

51 ed the codepletion of NK and CD4 T cells, NK cells depletion alone eliminated CAV at 3 weeks.

52 enic mice sensitized to ovalbumin antigen, B cell depletion also impaired allospecific memory T cell

53 NK cell depletion also led to decreased production of IL-22

54 We applied cell depletion and adoptive transfer strategies using ly

55 Cell depletion and adoptive transfer studies showed that

56 cell maintenance are key to preventing stem cell depletion and aging.

57 bust clinical responsiveness of IgG4-RD to B cell depletion and by the identification of multiple sel

58 ion is characterized by progressive CD4(+) T-cell depletion and CD8(+) T-cell expansion, and CD4(+) T

59 By combining epithelial cell depletion and cell culture in media with high conce

60 Lung CD4(+) T-cell depletion and dysfunction, CD8(+) T-cell alveolitis

61 y removed the pericardial AT and performed B-cell depletion and granulocyte-macrophage colony-stimula

62 term adverse effects were rare, except for B-cell depletion and hypogammaglobulinemia.

63 animals, and drug or antibody strategies for cell depletion and immunoglobulin signaling blockade wer

64 rful antitumor strategy involving both tumor cell depletion and immunosurveillance.

65 elomere shortening, early apoptosis leads to cell depletion and insufficient compensatory proliferati

66 TD)/Runx1 mutations cause hematopoietic stem cell depletion and myeloid progenitor expansion during a

67 aimed to determine mechanisms of human Treg cell depletion and reconstitution after anti-CD25 monocl

68 oHSV therapy was sufficient to phenocopy NK-cell depletion and suppress tumor growth and prolong sur

69 IL-15 complexes in response to Ab-mediated T cell depletion and TBI, suggesting products of cell deat

70 f SVV antigen in multiple tissues upon CD4 T cell depletion and virus reactivation suggests a critica

71 iption, thereby resulting in intestinal stem cell depletion and Wnt-uncoupled progenitor expansion.

72 rus match, conditioning intensity, type of T-cell depletion, and graft type.

73 e evidence of ongoing inflammation, CD4(+) T cell depletion, and perhaps even inflammation-associated

74 tics and extent of SIV replication, CD4(+) T cell depletion, and the onset of AIDS were comparable be

75 R2 transgenic mice received Ad/E2TM after NK cell depletion, and they produced less HER2 IgG, demonst

76 sistant to previous medications, including B-cell depletion, and who switched to tocilizumab (6-8 mg/

77 Immunohistochemical analyses and a cell-depletion approach indicated neutrophils as the maj

78 Using genetic and cell depletion approaches, we generated iNKT cell-defici

79 umour necrosis factor (TNF) inhibition and B-cell depletion are highly effective treatments for activ

80 ation exposure, light skin color, sex, and T-cell depletion are risk factors for cutaneous malignant

81 ng liver macrophages following acute Kupffer cell depletion as a means to infer signaling pathways an

82 NK-cell depletion as well as TRAIL and NKG2D pathway blocka

83 BI), cyclophosphamide, or Thy1 Ab-mediated T cell depletion, as well as in RAG(-/-) mice; interesting

84 induced by memory helper T cells, and CD8 T cell depletion at the time of transplantation or depleti

85 Here, we show that chronic B cell depletion (Baffr deficiency) significantly reduces

86 Here, we investigated the outcome of B-cell depletion (Bdep) therapy on CD8(+) T-cell-mediated

87 B-cell depletion before HDM challenge in HDM-sensitized mi

88 tein-specific Ab responses, and gammadelta T cell depletion before infectious challenge did not ablat

89 Mice were also subject to transient Treg cell depletion before sensitization with OVA plus SEA.

90 spheres with stunted folia, profound granule cell depletion, Bergmann gliosis, and signs of Purkinje

91 -TCRgammadelta antibody-induced gammadelta T-cell depletion blunted Ang II-induced SBP rise and endot

92 Anti-CD3 administration induces transient T cell depletion both in preclinical and in clinical studi

93 reventing myonuclear accretion via satellite cell depletion, both the number of transcriptionally act

94 SR141716), and by clodronate-induced myeloid-cell depletion, but not by genetic invalidation or block

95 antiatherogenic effects are unrelated to NK-cell depletion, but to CD8(+) T and NKT cells.

96 patients show anti-tumor activity through B-cell depletion by anti-CD20 antibody.

97 In monkeys, assessment of safety and target cell depletion by the high- and low-affinity TDBs reveal

98 Such subsets likely explain why B cell depletion can either ameliorate or exacerbate infla

99 T cell depletion can prevent hypertension in experimental

100 bitory KIR showed weak activation and target cell depletion capacity when incubated with rituximab an

101 Regulatory T cell depletion completely reverses this immune downmodul

102 ptor alpha (IL-7Ralpha) alone or following T cell depletion confers an advantage for allograft surviv

103 reduced infectious ZIKV levels, and CD8(+) T cell depletions confirmed that CD8(+) T cells mediated t

104 enhanced anti-FVIII antibody formation, MZ B-cell depletion continued to display similar effectivenes

105 ncluding basophil and plasmacytoid dendritic cell depletion, correlate strongly with disease severity

106 Peripheral CD4(+) T-cell depletion correlated with granulomas that contained

107 Peripheral CD4(+) T-cell depletion correlated with increased M. tuberculosis

108 However, CD8(+) T-cell depletion decreased chemokine (CC-motif) ligand ser

109 We further evidenced that CD8(+) T-cell depletion decreased levels of mature monocytes and

110 NK cell depletion did not affect amyloid beta concentration

111 Satellite cell depletion did not alter diaphragm mean fibre cross-

112 ponse to B cell-derived exosomal proteins, B cell depletion did not alter the exosome-induced CTL res

113 ne (CXC-motif) ligand 1 expression, CD8(+) T-cell depletion did not directly affect monocyte recruitm

114 control, because 2B4 blockade after CD8(+) T-cell depletion did not further aggravate symptoms of EBV

115 e markedly CD4(+) T cell dependent, CD4(+) T cell depletion did not impact quantities of IgG cross-re

116 The kinetic of Treg cell depletion did not parallel the disappearance of CD2

117 y antibody response, demonstrating that MZ B-cell depletion did not result in FVIII tolerance.

118 KEY POINTS: Satellite cell depletion does not affect diaphragm adaptations to

119 Progressive T cell depletion during chronic human immunodeficiency vir

120 t pathway that plays a central role in CD4 T cell depletion during disease progression to AIDS.

121 ve understanding of the mechanisms driving T cell depletion during HIV infection.IMPORTANCE In HIV-in

122 is in bystander CD4 T cells.IMPORTANCE CD4 T cell depletion during HIV-1 infection involves the demis

123 Satellite cell depletion early in life (4 months of age) has minim

124 Consequently, additional posttransplant B cell depletion effectively prevents late rejection and p

125 Anti-CD20 B cell depletion effectively reduces disease activity in M

126 show that PD-L1 blockade together with CD4 T cell depletion effectively rescued deeply exhausted CD8

127 Although Treg cell depletion enhances tumor rejection, the ensuing aut

128 chronic inflammation and Ag exposure, CD4 T-cell depletion, etc., alone does not cause poly- and aut

129 Interestingly, NK cell depletion experiments demonstrated a critical cutof

130 Adoptive transfer of serum and T-cell depletion experiments demonstrated a dominant role

131 Cell depletion experiments demonstrated that neutrophils

132 In vivo cell depletion experiments in two orthotopic HCC mouse m

133 alreticulin, prophylactic immunization and T-cell depletion experiments showed that melphalan adminis

134 une activation relative to APOE2 mice, and T cell depletion experiments showed that the effect of APO

135 endritic cells were each implicated based on cell depletion experiments.

136 Rituximab-mediated B-cell depletion followed by adoptive transfer of B cells

137 rbed doses with experimental measurements of cell depletion for platelets, progenitors, and precursor

138 le of B cells could explain the success of B-cell depletion for remission of AIH despite its classifi

139 TAT5, and its loss resulted in gammadeltaT17 cell depletion from all adult organs.

140 NK cell depletion from PBMCs prior to their intrasplenic in

141 because it was eliminated by local CD4(+) T cell depletion from the cornea.

142 By contrast, CD8(+) T cell depletion had no apparent impact on osteoblast abla

143 otocols use unmanipulated (without ex vivo T-cell depletion) haploidentical grafts combined with enha

144 While CD4(+) T cell depletion has been considered the major cause of HI

145 data suggest that IL-7R blockade following T cell depletion has potential as a robust, immunosuppress

146 seminiferous tubule niche, resulting in germ cell depletion, hypofertility, intratubular germ cell ne

147 However, M96 caused NK cell depletion if given 4 d prior to septic challenge an

148 and redox state are associated with CD4(+) T cell depletion, immune activation, and inflammation.

149 te that alphaCD3 alone induced substantial T-cell depletion, impacting both conventional T cells (T(c

150 conditioning was used in 80%, and in vivo T-cell depletion in 81%, of cases.

151 controlling infection by carrying out CD8 T cell depletion in an additional two animals of each spec

152 oimmune T cell activation after regulatory T cell depletion in an established model of systemic autoi

153 ges underlying the AIH remission caused by B-cell depletion in an experimental model of AIH.

154 and BAF312 caused a profound CD4+ and CD8+ T cell depletion in blood and lungs but only treatment wit

155 Our results indicate that muscle stem cell depletion in dKO muscle is related to upregulation

156 Acute B cell depletion in either 2- or 4-mo-old mice significant

157 Antibody-mediated CD4(+) T-cell depletion in HF mice (starting 4 weeks after ligati

158 Antibody-mediated CD8(+) T-cell depletion in high-fat diet-fed Ldlr(-/-) mice decre

159 Rituximab-induced B cell depletion in IgG4-RD leads to rapid clinical and hi

160 g2(-/-) mice, an effect mimicked by CD8(+) T-cell depletion in immunocompetent mice.

161 We characterized the consequences of CD4 T cell depletion in mice where virulent Salmonella establi

162 we show, using anti-CD20-mediated partial B cell depletion in mice, that a population of mature B ce

163 However, whether B cell depletion in normal adult mice has the same effect

164 he success of clinical trials of selective B-cell depletion in patients with relapsing multiple scler

165 Here we show that T cell depletion in the chronic phase of this model increa

166 ccessful use of costimulatory blockade and B-cell depletion in the clinic has revealed that the adapt

167 Prolonged satellite cell depletion in the diaphragm does not result in exces

168 g of HIV/SIV pathogenesis and implicate MAIT cell depletion in the disease process.

169 we have observed a rapid occurrence of stem cell depletion in the dystrophin/utrophin double knockou

170 CD8(+) T cell depletion in the effector phase of disease attenuat

171 myloid polypeptide (IAPP) is responsible for cell depletion in the pancreatic islets of Langherans, a

172 T-cell depletion in the R+/D- setting may actually, theref

173 ected humans, our data suggest that CD4(+) T cell depletion in the setting of HIV disease may reflect

174 ms have been invoked to account for CD4(+) T cell depletion in this setting, but the quantitative con

175 -2 and HIV-1 support similar levels of CD4 T cell depletion in vitro despite HIV-2 Vpx-mediated degra

176 nt mechanism underlying progressive CD4(+) T cell depletion in vivo.

177 Furthermore, T-cell depletion in wild-type mice after transverse aortic

178 gulation of Pax3 mRNA+ cells after satellite cell depletion in young and aged mice suggests that Pax3

179 In vitro, CD14(pos)- and CD15(pos)-cell depletion increased T-cell proliferation in patient

180 Finally, Treg cell depletion increases APC numbers in the spinal cord

181 Of 5172 patients, 941 (18%) received T-cell depletion induction, 1635 (32%) received interleuki

182 However, B cell depletion inhibited alloantibody generation and sig

183 Myeloid cell depletion inhibited metastatic growth with a marked

184 ential new therapeutics, centered on naive T-cell depletion, interleukin-17/21 inhibition, kinase inh

185 CD4 T-cell depletion is a hallmark of HIV/AIDS, but the underl

186 lood transplantation (CBT) without in vivo T-cell depletion is increasingly used to treat high-risk h

187 on and CD8(+) T-cell expansion, and CD4(+) T-cell depletion is linked directly to the risk for opport

188 ent, and (iii) rebounding virus after CD8(+) cell depletion is replication competent and genetically

189 eration rates increased in TA-TLSs upon Treg cell depletion, leading to tumor destruction.

190 During disseminating virus infection, B cell depletion led to sustained weight loss and function

191 ioning regimen consisting of pretransplant T cell depletion, low-dose total body irradiation and post

192 understanding tolerance induction and how B cell depletion may prevent tolerance.

193 Progression to AIDS is driven by CD4 T cell depletion, mostly involving pyroptosis elicited by

194 Whether satellite cell depletion negatively impacts diaphragm quantitative

195 In cells, depletion of DjA1 resulted in Golgi fragmentation

196 In mouse cells, depletion of ER luminal FKBP10 was almost as pote

197 olishing cGAMP production in Cgas(-/-) tumor cells, depletion of extracellular ATP, or inactivation o

198 In human cancer cells, depletion of miR181ab1 impaired proliferation and

199 of NKG2C(pos) NK cells on HLA-E(high) CD8 T cells, depletion of NKG2C(pos) NK cells enhanced Ag-spec

200 effector/memory conversion of Ag-specific T cells, depletion of peripheral CD4(+) T cells in hematol

201 Of importance, in human cells, depletion of TRAPPC11, but not other TRAPP compon

202 In mesenchymal precursor cells, depletion of WTX and TRIM28 resulted in analogous

203 This enhancing effect of delayed NK cell depletion on antiviral immunity, in contrast to ear

204 To test effects of T cell depletion on cardiac function, we gave CKD mice ant

205 the effect of anti-CD20 antibody-mediated B cell depletion on CD4(+) and CD8(+) memory T cell allore

206 els of GVHD to evaluate the effect of CD4+ T cell depletion on GVL versus GVHD and revealed that depl

207 Next, we tested the influence of B cell depletion on hematopoietic chimerism.

208 B-cell depletion or granulocyte-macrophage colony-stimulat

209 B-cell depletion or IL-10 deficiency in B cells prevented

210 mphocyte infiltration and are abolished by T cell depletion or interferon-gamma neutralization.

211 More importantly, B-cell depletion or TNFalpha neutralization can restore th

212 igen-specific T cell expansion, T regulatory cell depletion, or effector T cell function.

213 treatment in vivo, CXCR3 blockade, CD8(+) T cell depletion, or IFN-gamma neutralization each inhibit

214 Adjuvant removal, B cell depletion, or IL-10 blockade recovers its antitumor

215 Analogous to myeloid cell depletion, overexpression of ANGPTL7 in cancer cell

216 Unlike B cell depletion, pan-T cell aplasia is prohibitively toxi

217 CORT treatment after beta-cell depletion partially restored beta-cells.

218 Although it has been speculated that stem cell depletion plays a role in the rapid progression of

219 on, although short-term (3-d) local CD4(+) T cell depletion postinfection did not influence chemokine

220 B-cell depletion prevented costimulatory blockade-induced

221 both type I IFN receptor blockade and CD8 T cell depletion prevented infection-induced barrier leaka

222 ponses during the sensitization phase or Tfh cell depletion prevented Th2 cell-mediated responses fol

223 We found that B cell depletion prevented the development of memory allor

224 Kupffer cell depletion prevented the removal of aged platelets f

225 Although B-cell depletion prevents alloantibody formation, nonhumor

226 ts with LRBA deficiency revealed marked Treg cell depletion; profoundly decreased expression of canon

227 ymphodepleted animals or regulatory T (Treg) cell depletion promoted GzmB expression by tumor-infiltr

228 -A within HSV-1-infected corneas, and CD4(+) cell depletion promoted reinnervation of HSK corneas wit

229 effects of CD79-targeted mAbs do not require cell depletion; rather, they act by inducing an anergic-

230 While CD11c+ cell depletion reduced IL-6, IL-1beta, CXCL1, CXCL2 and

231 B cell depletion reduced stroke-induced hippocampal neurog

232 NK cell depletion reduces the pace of MN degeneration, dela

233 secreting beta cells following targeted beta cell depletion, regenerating the form and function of th

234 To investigate the contribution of CD4+ T cell depletion relative to other mechanisms of SIV-induc

235 and cellular mechanisms responsible for stem cell depletion remain poorly understood.

236 ate that haplo-HSCT after alphabeta T- and B-cell depletion represents a competitive alternative for

237 Antifungal treatment or autoreactive CD4 T cell depletion rescues, whereas oral fungal administrati

238 lyzing individual granulomas revealed that B cell depletion resulted in altered local T cell and cyto

239 inated rats prolongs infection, while CD4(+) cell depletion results in chronic viremia.

240 either spontaneous nor experimental CD4(+) T cell depletion results in substantial levels of in vivo

241 Lineage-specific cell depletion revealed that Tregs promote HF regenerati

242 In addition to B-cell depletion, rituximab can modulate the immune respon

243 T cell depletion significantly improved both diastolic fun

244 ers had significant LT fibrosis and CD4(+) T-cell depletion, similar to noncontrollers, but the so-ca

245 s significantly reduced by systemic CD4(+) T cell depletion starting before infection, although short

246 Specific in vivo cell depletion strategies have allowed us to demonstrate

247 g therapeutic approach but experience with B-cell depletion strategies remains limited.

248 ese studies will facilitate development of T-cell depletion strategies to augment the feasibility of

249 Using adoptive transfer and B cell depletion strategies, we determined that optimal pr

250 cently described hamster model, along with T-cell depletion strategies, we show that CD4(+) T cells a

251 By using various cell-depletion strategies, we find that, whereas lymphoc

252 Using cell-depletion strategies, we show that regeneration is

253 Adoptive transfer and cell depletion studies demonstrate that DENV-immune CD8(

254 Immune cell depletion studies demonstrated that CD4(+) and CD8(

255 Immune cell depletion studies indicated that CD8 T cells, but n

256 CD4(+) T-cell depletion studies or the adoptive transfer of WT OV

257 vo cannot account for the extent of CD4(+) T cell depletion, suggesting indirect or bystander mechani

258 how that MRV infects the thymus and causes T-cell depletion, suggesting that other roseoloviruses may

259 macrometastases triggered by natural killer cell depletion suggests a dynamic interplay between deve

260 tential therapeutic approaches focusing on B-cell depletion that could be used to translate experimen

261 Their resistance to in vivo B-cell depletion, that is, their independency from supply

262 mmune complexes suppressed antibody-mediated cell depletion, therapeutic antibody-killing of LCMV inf

263 The success of B cell depletion therapies and identification of leptomeni

264 abdominal aortic aneurysm (AAA) receiving B-cell depletion therapy highlight the importance of under

265 The efficacy of B cell depletion therapy in multiple sclerosis indicates t

266 T-cell depletion therapy is associated with diminished int

267 elated to AMA, and that AMA reduction with B-cell depletion therapy will improve fatigue.

268 The study sought to determine whether B cell depletion therapy would attenuate the development o

269 ositive patients receiving rituximab-based B-cell depletion therapy.

270 sis, in part as a result of the success of B cell-depletion therapy.

271 ion of immune cell trafficking versus immune cell depletion, thereby substantially expanding the avai

272 Upon Lgr5(+) cell depletion, these cells are recruited to contribute

273 NK cell depletion through treatment with anti-IL-15 monoclo

274 Anti-oxidant treatment, Kupffer cell depletion, Tnfr1 deletion, or JNK inhibition reduce

275 nally, we demonstrate that the addition of B cell depletion to the transfer of regulatory T cells (Tr

276 n sodium sulphate treatment and T regulatory cell depletion using C57BL/6-FoxP3(DTR) mice) were used

277 Regulatory T cell depletion using PC61 antibody was used to examine t

278 B-cell depletion using several infusions of rituximab over

279 The effects of B cell depletion varied among granulomas in an individual

280 B cell depletion via anti-CD20 antibodies is a highly effe

281 of tolerance induction by CD3 mAb-mediated T-cell depletion, warranting caution in their use for the

282 Mechanistically, Treg-cell depletion was associated with M1-like macrophage po

283 In this subpopulation, memory B-cell depletion was unable to prevent relapse, which was

284 antiviral immunity, in contrast to early NK cell depletion, was not associated with increased morbid

285 induction, T-cell stimulation, regulatory T cell depletion-was observed at all dose levels.

286 donor type (mother) and GVHD prophylaxis (T-cell depletion) were also significant predictors of aGVH

287 his attenuation was partially reversed by NK cell depletion, whereas the simultaneous depletion of mo

288 the tumor site prevented intra-tumoral Treg cell depletion, which may underlie the lack of anti-tumo

289 Here, TMEV infection induced splenic T cell depletion, which was associated with lower anti-vir

290 Our approach was to utilize differential B-cell depletion with anti-CD20 to retain B cells whose pr

291 Systemic myeloid cell depletion with anti-Gr-1 antibody blocked the impro

292 d dry eye disease, and evaluated memory Th17 cell depletion with anti-IL-15 antibody as a strategy to

293 omized studies have suggested that in vivo T-cell depletion with anti-T-lymphocyte globulin (ATLG; fo

294 Antecedent Kupffer cell depletion with clodronate liposomes (0.5 mg/kg).

295 rved in nontransplanted mice and after CD8 T cell depletion with mAb instead of mATG.

296 We hypothesized that CAR T-cell depletion with optimal timing after AML eradication

297 Arguably, the success of B cell depletion with rituximab in open-label clinical tri

298 B-cell depletion with rituximab may therefore be noninferi

299 revealed that Treg loss was primarily due to cell depletion, with minimal evidence of Treg conversion

300 administration of Sandy-2 in mice induced B cell depletion within 2 weeks, down to levels close to t