ライフサイエンスコーパス: cell differentiation

1 id cell differentiation at the expense of NK cell differentiation.

2 in vitro and in vivo, thereby inducing stem cell differentiation.

3 odes, and increased T-helper type 2 (T(H) 2)-cell differentiation.

4 al dynamics of chromatin as a determinant of cell differentiation.

5 and T-bet in TLR7-driven GC, Tfh and plasma cell differentiation.

6 he study of specific O-glycan changes during cell differentiation.

7 ive heterochromatin and is required for stem cell differentiation.

8 g its activation and thereby increasing Th17 cell differentiation.

9 r depalmitoylation negatively affects T(H)17 cell differentiation.

10 thelial repair, and implicate ST2 in myeloid cell differentiation.

11 stimulus-dependent alternative pathways of T cell differentiation.

12 ey role in lineage specification during stem cell differentiation.

13 ted B-cell class switching to IgE and plasma cell differentiation.

14 n receptor (AhR) and ultimately induces Th17 cell differentiation.

15 34 induced apoptosis, cell cycle arrest, and cell differentiation.

16 cell metabolism, early stage apoptosis, and cell differentiation.

17 (NGF) promotes sustained ERK activation and cell differentiation.

18 ves severe disruption to syncytiotrophoblast cell differentiation.

19 gation of TADs is further exacerbated during cell differentiation.

20 x for investigating human and mouse CD8(+) T cell differentiation.

21 IL)-2 and IL-21 dichotomously shape CD8(+) T cell differentiation.

22 olite of vitamin D) in the regulation of Th9 cell differentiation.

23 intracellular calcium homeostasis, and stem cell differentiation.

24 WNT-beta-catenin axis and facilitates T(FR) cell differentiation.

25 es in mDCs impact their ability to promote T-cell differentiation.

26 R1) as a selective regulator of intestinal L-cell differentiation.

27 orphan receptor gamma t (ROR-gammat)(+) Treg cell differentiation.

28 s, analogous to kinetic proofreading of stem-cell differentiation.

29 ssion, CSR, somatic hypermutation and plasma cell differentiation.

30 beta and IL-6, cytokines known to drive Th17 cell differentiation.

31 on limitation is a signal modulating swarmer cell differentiation.

32 cription factors involved in neuroepithelial cell differentiation.

33 lopment, including stem cell maintenance and cell differentiation.

34 re ineffective in driving encephalitogenic T cell differentiation.

35 dysregulated gene expression and delayed ES cell differentiation.

36 revealed low tonic signaling promotes T(FH) cell differentiation.

37 ring gut lymphocyte homing and IgA(+) plasma cell differentiation.

38 n heavy chain cluster during skeletal muscle cell differentiation.

39 es NFkappaB-p65 at K310 to modulate T helper cell differentiation.

40 plicated in retinal pigment epithelial (RPE) cell differentiation.

41 d needs to be significantly remodeled during cell differentiation.

42 ting of key transcription factors regulating cell differentiation.

43 ovascular development and stem or progenitor cell differentiation.

44 nitor self-renewal and defective white blood cell differentiation.

45 sms of calcitriol-mediated regulation of Th9 cell differentiation.

46 ry are synthesized into integrated models of cell differentiation.

47 of chromatin regulation, for example during cell differentiation.

48 amino acid sensing, cell-cell signaling, and cell differentiation.

49 riptional program that promotes regulatory T-cell differentiation.

50 5 under-represented TFs primarily regulating cell differentiation.

51 -cell renewal and is a negative regulator of cell differentiation.

52 s active during fetal and adult gammadelta T-cell differentiation.

53 d ADAD2, on testis RNA editing and male germ cell differentiation.

54 andscape of regulatory mechanisms underlying cell differentiation.

55 bit tumour growth and stimulate regulatory T cell differentiation.

56 cantly increased GM-CSF production and T(H)2 cell differentiation.

57 suggesting that infected cells can undergo T cell differentiation.

58 n to the dLN where they initiated T helper-2 cell differentiation.

59 tor cell proliferation and dental epithelium cell differentiation.

60 memory B cells (MB), while impairing plasma cell differentiation.

61 is pathway, which is required for mature AT1 cell differentiation.

62 ssion of myelin genes and a delay in Schwann cell differentiation.

63 priming in identifying novel regulators of T cell differentiation.

64 tor ETS1 is critically required for human NK cell differentiation.

65 Notably, MYC abundance decreases with plasma cell differentiation, a key lytic reactivation trigger.

66 gy provides a blueprint for comparing immune cell differentiation across developmental stages.

67 lity in naive T cells during T(H)1 and T(H)2 cell differentiation after stimulation with TCR ligands

68 y two qualitatively different mechanisms: by cell differentiation along the hierarchy "washing out" h

69 t into the mechanisms of CD4(+) and CD8(+) T cell differentiation and a foundation for mechanistic in

70 ells, has been intensively investigated in B cell differentiation and Ab class switch.

71 In summary, Glrx ablation stimulated 3T3L1 cell differentiation and adipogenesis via increased prot

72 ssary and sufficient for TSLP-mediated T(H)2-cell differentiation and airway inflammation.

73 , T cell-specific PKM2 deletion impairs Th17 cell differentiation and ameliorates symptoms of EAE by

74 ent modality that naturally adjuvants plasma cell differentiation and antibody responses to protein a

75 progression, is a key factor mediating Th17 cell differentiation and autoimmune inflammation.

76 show that Dot1l is induced during brown fat cell differentiation and by cold exposure and that Dot1l

77 nterest triggered by its involvement in stem cell differentiation and cancer has led to rapid advance

78 ors are required for stem-cell pluripotency, cell differentiation and cell reprogramming(1,2).

79 Consequently, EPKs play crucial roles in cell differentiation and cell-cycle progression, and kin

80 positively associated with genes involved in cell differentiation and cell-wall biosynthesis.

81 l the transcriptional and chromatin basis of cell differentiation and dedifferentiation in intestinal

82 ermal organogenesis and pancreatic precursor cell differentiation and development.

83 plays an important role in thymic epithelial cell differentiation and development.

84 l key transcriptional regulators involved in cell differentiation and disease development.

85 n, with broad relevance for pluripotent stem cell differentiation and disease modeling.

86 While the transcriptional control of CD8 T cell differentiation and effector function following T c

87 y respond to dynamic transitions during stem cell differentiation and embryonic development.

88 cidates a role for TET2 in governing luminal cell differentiation and endocrine response that underli

89 eveal a mechanism regulating intestinal stem cell differentiation and epithelial repair following inj

90 discuss recent insights into memory CD8(+) T cell differentiation and exhaustion and the association

91 n, CD28-YMFM CAR-T cells exhibited reduced T cell differentiation and exhaustion as well as increased

92 ses downstream of the BCR is essential for B cell differentiation and function and is disturbed in ch

93 Cell differentiation and function are regulated across m

94 nonmetabolic regulator that fine-tunes Th17 cell differentiation and function in autoimmune-mediated

95 the polyamine spermidine as a modulator of T-cell differentiation and function.

96 lic pathways can alter or prevent effector T cell differentiation and function.

97 early role for NR4A3 in programming CD8(+) T cell differentiation and function.

98 ells and its activity is essential for T(FH) cell differentiation and function.

99 growth factor; it lays the foundation for T cell differentiation and immunological memory.

100 On memory cell differentiation and in most EBV-associated Burkitt'

101 important regulator of effector and memory T cell differentiation and induces a population of stem ce

102 ine progenitor population impairs mouse beta cell differentiation and induces ectopic expression of c

103 by its ability to induce regulatory T (Treg) cell differentiation and inhibit Th1 and Th2 responses.

104 elper cell responses, and promoting memory T cell differentiation and maintenance.

105 molecular mechanisms that drive normal stem cell differentiation and malignant transformation.

106 IR of female PGCs caused uncoupling of germ cell differentiation and meiotic initiation, while male

107 ein that promotes oligodendrocyte progenitor cell differentiation and myelination in vitro and ex viv

108 lism, extracellular matrix remodelling, beta-cell differentiation and non-beta-cell trans-differentia

109 Th17 cell differentiation and pathogenicity depend on metabol

110 ndent mechanism that selectively drives Th17 cell differentiation and pathogenicity in autoimmunity.

111 e involved in biological processes including cell differentiation and proliferation (ggnb2, mod5, rer

112 ulin secretion (GSIS) and expression of beta-cell differentiation and proliferation markers in human

113 Cell differentiation and proliferation require Hedgehog

114 pic expression of KNOTTED1 (KN1) accelerates cell differentiation and promotes development of the she

115 um infection and provide signals to direct B cell differentiation and protective antibody expression.

116 by its inhibitor DHTS inhibited splenic Th17 cell differentiation and reduced experimental autoimmune

117 With HIV infection, B cell differentiation and regulatory markers are discrete

118 formation, in part through the regulation of cell differentiation and secondary cell wall biosynthesi

119 GF ligands may contribute to vestibular hair cell differentiation and supports a developmental model

120 Determining factors in T cell differentiation and survival include antigen recogn

121 ellular localization and for balancing CD8 T cell differentiation and survival.

122 d proteomic regulation of hematopoietic stem cell differentiation and the induction of leukemia and l

123 ate maintenance is an integral part of plant cell differentiation and the production of functional ce

124 ar pore complex components in embryogenesis, cell differentiation and tissue-specific processes.

125 cale rearrangements in genome structure upon cell differentiation and tumor progression.

126 le for LDH in modulating cytokine-mediated T cell differentiation and underscore the therapeutic pote

127 expressed in GC B cells that promotes plasma cell differentiation and viral reactivation.

128 age of colonic stem cells, promotion of stem cell differentiation, and attenuation of FoxM1 signaling

129 nt defective immune responses, impaired Th17 cell differentiation, and higher fungal burden.

130 ajectory construction and stem or progenitor cell differentiation, and the comparison of healthy and

131 ough the molecular pathways underlying islet cell differentiation are beginning to be resolved, the c

132 Bioinformatics analysis identified cell differentiation as one biological function being sp

133 early marker in oligodendrocytes progenitor cell differentiation as well as GalC(+)/O1(+) premyelina

134 cell fate assays to chart basophil and mast cell differentiation at single-cell resolution in mouse.

135 80(-)) NKDIs promoted non-NK innate lymphoid cell differentiation at the expense of NK cell different

136 ition of CTCF or its deletion blocks Schwann cell differentiation at the pro-myelinating stage, where

137 changes in the DGIE scores occurring during cell differentiation based on three real single-cell dat

138 utant models, allowed overcoming of B- and T-cell differentiation blocks and thymic epithelial cell d

139 ion of IL-12 and IL-23 was able to restore T cell differentiation both in vitro and in vivo in the co

140 Disease development and cell differentiation both involve dynamic changes; there

141 en potentially implicated in endocytosis and cell differentiation but its molecular functions remaine

142 the variational autoencoder, that can model cell differentiation by building meaningful representati

143 Mechanistically, DOT1L controlled CD8(+) T cell differentiation by ensuring normal T cell receptor

144 on, suggesting that LSD1 regulates endocrine cell differentiation by limiting the duration of RA sign

145 le in regulating Sim expression and follicle cell differentiation can be replaced by its mouse homolo

146 duced mutant that exhibits abnormal mesocarp cell differentiation could help elucidate determinants o

147 BNA3A-mediated inhibition of terminal plasma cell differentiation critically control EBV-mediated B c

148 dies have reported KDM6A's critical roles in cell differentiation, development, and cancer.

149 Polarization is a crucial component in cell differentiation, development, and motility, but its

150 Our results thus suggest that Th cell differentiation does not require specialized APC su

151 epigenetic program that triggers neural stem cell differentiation during cortical development.

152 ntrast, the replacement H3.3 variant opposes cell differentiation during early embryogenesis.

153 compensate for the loss of SOX9 for Sertoli cell differentiation during female-to-male sex reversal.

154 late the balance between effector and memory cell differentiation during T cell activation.

155 n significantly associated with CD8 memory T-cell differentiation (effector memory, naive, and T-bet-

156 eficiency does not affect hematopoietic stem cell differentiation, engraftment, or mobilization, whic

157 isplayed loss of ERK signaling and defective cell differentiation, Etv deficiency augmented ERK phosp

158 Here we summarize these NK cell differentiation events, review evidence for direct

159 e will help facilitate the manipulation of B cell differentiation for vaccine development or to treat

160 rgo highly dynamic changes during adult stem cell differentiation from intestinal progenitors to diff

161 uce realistic simulations of the dynamics of cell differentiation from only static images.

162 ablish a high-resolution map of gammadelta T-cell differentiation from the fetal and adult thymus usi

163 s demonstrated a trajectory of myeloid and T cell differentiation from the periphery inward.

164 Epigenetic changes during B-cell differentiation generate distinct DNA methylation s

165 identify a systematic downregulation of hair cell differentiation genes, concomitant with robust upre

166 to various cellular processes including Th17 cell differentiation, has been implicated in MS.

167 mental embryology, genetic circuits and stem cell differentiation have shaped our understanding of th

168 of key transcription factors that control NK cell differentiation (ie, E4BP4, TXNIP, TBET, GATA3, HOB

169 to understand transcriptional regulation of cell differentiation in a dynamic context.

170 n turn promoting Th17 cell and Th1-like Th17 cell differentiation in C57BL/6J mice.

171 How rapid cell multiplication leads to cell differentiation in developing tissues is still enig

172 c shifts is gaining momentum in the study of cell differentiation in embryonic development, adult ste

173 Cell differentiation in multicellular organisms requires

174 l expansion, isotype switching, and memory B cell differentiation in response to T cell-independent t

175 RSL genes which positively regulate cell differentiation in roots were either exclusively or

176 Here, we demonstrate that cell differentiation in spermathecae involves different

177 ) peptide CLE40, a peptide regulator of stem cell differentiation in the Arabidopsis (Arabidopsis tha

178 es, has revealed new candidate regulators of cell differentiation in the hindbrain.

179 showed that TSLP can directly promote T(H)2-cell differentiation in the lung, independent of the dra

180 ing transcriptional networks direct CD4(+) T cell differentiation in the lymphoid organs and tissues.

181 How Zeb2 subdomains support cell differentiation in various contexts has remained el

182 ivation, B cell proliferation, and dendritic cell differentiation in vitro and suppresses immune resp

183 Spermidine modulates CD4(+) T-cell differentiation in vitro, preferentially committing

184 RIM32 deficiency contributes to enhanced Th2 cell differentiation in vitro.

185 o investigate alveolar epithelial progenitor cell differentiation in vitro.

186 t spermidine treatment, to evaluate CD4(+) T-cell differentiation in vitro.

187 thus define the cell division kinetics of B cell differentiation in vivo, and identify the molecular

188 circumstances have been shown to affect stem cell differentiation in vivo.

189 ayers of fate decisions that inform CD4(+) T cell differentiation in vivo.

190 . rodentium infection due to suboptimal Th17 cell differentiation in vivo.

191 e observed, together with induction of blast cell differentiation, in particular, in patients with ML

192 y dynamic processes, including in vitro stem cell differentiation, in vivo development, oncogenesis,

193 structed a detailed map of basophil and mast cell differentiation, including a bifurcation of progeni

194 tory molecules involved in proinflammatory T cell differentiation, including cluster of differentiati

195 e highlighted a role for mitochondria during cell differentiation, including in skin epidermis.

196 ing as new, important regulators of terminal cell differentiation, including neurons and gametes.

197 of known contributing genes that facilitate cell differentiation increases from ES cells to terminal

198 To induce goblet cell differentiation, indole acts via the xenobiotic ary

199 omatin-repressive complexes to block Schwann cell differentiation inhibitors to control peripheral my

200 ological actions include direction of immune cell differentiation, initial response to invading patho

201 influence of myeloid progenitors on CD34(+) cell differentiation into CD56(+) innate lymphocytes.

202 These results establish extrafollicular B cell differentiation into short-lived AFCs as a key mech

203 ption of Ftz-f1 expression prevents follicle cell differentiation into the final maturation stage, wh

204 are constitutively unmethylated throughout T cell differentiation, irrespective of their activation s

205 Cell differentiation is accompanied by chromatin remodel

206 Cell differentiation is accompanied by epigenetic change

207 Dysregulated Th17 cell differentiation is associated with autoimmune disea

208 ated on the genome scale to determine immune cell differentiation is beyond our grasp.

209 standing of the mechanisms coordinating Treg cell differentiation is crucial for understanding numero

210 Cytotoxic T cell differentiation is guided by epigenome adaptations,

211 CD8 T cell differentiation is orchestrated by dynamic metaboli

212 Cell differentiation is regulated by HetR which activate

213 expression and 5hmC in adult (somatic) stem cell differentiation is still unknown.

214 odifier implicated in gene transcription and cell differentiation, is essential to mediate sprouting

215 s that are involved in tumor suppression and cell differentiation, leading to suppression of oncogene

216 .5 before the initiation of sensory receptor cell differentiation, making it a unique system for stud

217 ion of cell cycle control molecules and beta-cell differentiation markers upon diabetogenic challenge

218 hereas EBV-infected B cells expressed plasma cell differentiation markers.

219 direct target of Ftz-f1 to promote follicle cell differentiation/maturation and that Ftz-f1's role i

220 To assess T-cell differentiation, mDCs were cocultured with naive T(

221 m the embryo throughout adulthood, including cell differentiation, metabolic regulation, and inflamma

222 singly recognized as a significant factor in cell differentiation, migration, and in the case of canc

223 Therefore, GPNMB is involved in cell differentiation, migration, inflammation, metabolis

224 Leveraging a human stem cell differentiation model, we identify two clusters of

225 During multiciliated cell differentiation, motile cilia are templated from ba

226 nitor cells and neurons, and engaged in stem cell differentiation, neuron migration, and forebrain de

227 ine that RA-mediated regulation of endocrine cell differentiation occurs through Wnt pathway componen

228 equently increases oligodendrocyte precursor cell differentiation, oligodendrocyte generation and mye

229 precision within cells and to modulate Th17 cell differentiation on demand using UV light illuminati

230 able immune modulator (PIM) to increase Th17 cell differentiation on demand with spatial and temporal

231 l mean distances relative to speckles during cell differentiation or a physiological transition, sugg

232 ur ability to benchmark the fidelity of stem cell differentiation or cell programming, or interpret t

233 , increased aerobic glycolysis, favored Th17 cell differentiation over that of Treg cells, and promot

234 onsistent with an effect of GSK-J4 on Th17 T cell differentiation pathways directly related to prolif

235 insights from hematopoietic and neural stem cell differentiation pathways were used to identify canc

236 nhances STAT3 activation and promotes T(H)17 cell differentiation; perturbation of either palmitoylat

237 on, BSCs activate a hybrid basal and luminal cell differentiation program before giving rise to LCs-r

238 ly direct a pathogenic pro-inflammatory Th17 cell differentiation program, acting directly on T cells

239 s pathway in the regulation of individual Th cell differentiation programs.

240 ncluding those involved in proinflammatory T cell differentiation, prolonged monocyte major histocomp

241 ACH2 functions as a pervasive regulator of T cell differentiation, promoting development of CD4(+) T(

242 three distinct biological processes: myeloid cell differentiation, protein phosphorylation and synapt

243 Here, we report a stem cell differentiation protocol that uses transwell filter

244 Empirical optimization of stem cell differentiation protocols is time consuming, is lab

245 CR-CSC differentiation and recapitulates the cell differentiation-related gene expression profile by

246 netic mechanisms and any normal purpose in T cell differentiation remain unclear.

247 -mediated silencing of enhancers involved in cell differentiation represents a potential mechanism by

248 T helper cell differentiation requires lineage-defining transcrip

249 polarization and myeloid-derived suppressor cell differentiation, respectively, most likely in a TLR

250 e the gene expression changes that accompany cell differentiation, revealing that ectopic expression

251 tion of epithelial cells and promotes goblet cell differentiation, reversing an effect of aging.

252 essential roles in intracellular transport, cell differentiation, signaling, and motility.

253 In addition to a fundamental role in cell differentiation, some epigenetic changes can also b

254 transient requirement for LSD1 in endocrine cell differentiation spanning a short time-window early

255 fficiency has broad deleterious effects on B-cell differentiation, specifically hampering gut lymphoc

256 s, one that encompasses a gradient of ductal cell differentiation stages, and another featuring cells

257 we report that the key T helper 17 (T(H)17) cell differentiation stimulator, STAT3(3,4), is subject

258 ediated gene editing, coupled with endocrine cell differentiation strategies, we dissect the contribu

259 dynamics has relevance to regulation of stem cell differentiation, stress responses, and, potentially

260 ted mutagenesis together with functional and cell differentiation studies.

261 CD134), provides essential signals driving T cell differentiation, survival, and memory in part throu

262 l of alveolar epithelial type II (ATII)-like cell differentiation that allows us to investigate alveo

263 etween Trib1 and effector versus exhausted T cell differentiation that can be targeted to improve ant

264 er powerful GLP-1 secretagogues facilitate L-cell differentiation through a paracrine GLP-1-dependent

265 lation of the germinal center response and B cell differentiation to establish lifelong infection is

266 developmentally programmed temporal delay in cell differentiation to more quickly adapt to a surface-

267 on-coupled APA (SCAP), is also executed in B cell differentiation to plasma cells.

268 ethylation begin in the SAM long before germ cell differentiation to protect the genome from harmful

269 suppressed T cell activation, and altered T cell differentiation to suppressive regulatory phenotype

270 r maturity and can be utilized to guide stem cell differentiation to the hepatic lineage.

271 th an early specific block in Bcl-6(+) T(FH) cell differentiation together with an increase in T-bet(

272 The structure of the landscape drives single-cell differentiation toward one of these states during a

273 cal signaling was utilized to accelerate the cell differentiation toward osteogenic lineage.

274 us across the life span and to reconstruct T cell differentiation trajectories and T cell receptor (T

275 Cell differentiation typically occurs with concomitant s

276 iated with decreasing fetal pre-osteoblastic cell differentiation, under epigenetic control of SATB2

277 of signaling-center production through stem cell differentiation underlies proportional growth in ad

278 -Rel-deficient mice fully rescued terminal B cell differentiation, underscoring its critical B cell-i

279 nd PD-1 and CTLA-4 expression, and blocked T cell differentiation, until the cells quickly disappeare

280 B, might determine the precise outcome of Th-cell differentiation upon encounter with cDC1s.

281 older people and aged mice have impaired Tfh cell differentiation upon vaccination.

282 ity and flexibility and improve memory CD8 T cell differentiation, useful attributes for T cells used

283 tcome of RAF1 during mouse neural progenitor cell differentiation using an optogenetic RAF1 system (O

284 involved in inflammation, matrix remodeling, cell differentiation, vascularization, and steroid metab

285 ed that the heightened propensity for T(H) 2-cell differentiation was both T cell intrinsic and extri

286 Th17 cell differentiation was downregulated in galectin-9-def

287 ), one of the Rho-GTPases associated with Th-cell differentiation, was associated with downregulation

288 netic proteins (BMP) to promote colonic stem cell differentiation, we aimed to investigate whether an

289 At all stages of skeletal muscle cells differentiation, we show a permanent flux of T95 d

290 2 innate lymphoid cell activation, and T(h)2 cell differentiation were found in gut mucosa of mice nu

291 cellular transport undergoes remodeling upon cell differentiation, which involves cell type-specific

292 vation blocks immunosuppressive regulatory T cell differentiation, which is a potential therapeutic s

293 factors seemed as dominantly required for T cell differentiation, which may represent a fall-back pa

294 with HO and aberrant chondrogenic progenitor cell differentiation, while CD47-activating peptides tha

295 ess the Ealpha enhancer at early stages of T cell differentiation, while their decommission is requir

296 the molecular mechanisms of regulating Th17 cell differentiation will help find a novel therapeutic

297 nscriptional and epigenetic changes during B cell differentiation with cell division in vivo.

298 ADAD2 are essential regulators of male germ cell differentiation with molecular functions unrelated

299 E-protein transcription factors guide immune cell differentiation, with E12 and E47 (hereafter called

300 levels and regulates gene transcription and cell differentiation, yet the contributions of KDM5B to