ライフサイエンスコーパス: cell entry

1 of the pH-dependent transitions involved in cell entry.

2 coprotein spike complex responsible for host cell entry.

3 sufficiently flexible to disassemble during cell entry.

4 f ALV-J gp85 and efficiently mediating ALV-J cell entry.

5 d neutralized both fibroblast and epithelial cell entry.

6 t described as being important for Mammalian Cell Entry.

7 subvirion particles (ISVPs) that accompanies cell entry.

8 observed in virions exposed to the low pH of cell entry.

9 ization during fibroblast but not epithelial cell entry.

10 al change in the sigma1 protein during viral cell entry.

11 and deficient in surface proteins needed for cell entry.

12 undergoes structural transitions during host cell entry.

13 ny therapies under investigation target EBOV cell entry.

14 iruses became dependent on the inhibitor for cell entry.

15 lysis correlated with S conformations during cell entry.

16 re not only required but also sufficient for cell entry.

17 quirements for membrane penetration and host cell entry.

18 f angiotensin-converting enzyme 2 (ACE2) for cell entry.

19 rements for HERV-K ENV to mediate infectious cell entry.

20 loped viruses use the retrograde pathway for cell entry.

21 of endosomal host and viral membranes during cell entry.

22 f immune cell function and mediator of viral cell entry.

23 e the structural rearrangements required for cell entry.

24 for priming viral uncoating and facilitating cell entry.

25 the generation of infectious particles, and cell entry.

26 ight into the mechanism of MARV GP2-mediated cell entry.

27 glycoproteins able to utilize CLDN6 for host cell entry.

28 on at specific times and places during virus cell entry.

29 nd, importantly, inhibits sporozoite Kupffer cell entry.

30 infection by altering viral transport during cell entry.

31 (135S and 80S particles) and leads to virus cell entry.

32 rearrangements to permit membrane fusion and cell entry.

33 s are dispensable for MeV-induced fusion and cell entry.

34 nd E2 are important mediators for productive cell entry.

35 le to be those that offer optimal MERS virus cell entry.

36 activation is required for viral postbinding cell entry.

37 e 2 (ACE2), its main host receptor, and host cell entry.

38 ing maturation and endosome escape following cell entry.

39 ve, TeNT(RY), was engineered to analyze TeNT cell entry.

40 dotypes (HCVpp) and demonstrated a defect in cell entry.

41 scL's large pore may provide a mechanism for cell entry.

42 or budding but rather to a blockade of virus cell entry.

43 hus, SR-BI has at least two functions during cell entry.

44 ating toxins and implies their unfolding for cell entry.

45 or this crucial first step of bacterial host-cell entry.

46 o glycoproteins, G(N) and G(C), required for cell entry.

47 TGN/Golgi via the retrograde pathway during cell entry.

48 gh a shared requirement for endosomes during cell entry.

49 reatic lymph node thought to precede islet T cell entry.

50 g two glycoproteins, E1 and E2, required for cell entry.

51 endosomes and use multivesicular bodies for cell entry.

52 r bodies, were also found to be required for cell entry.

53 IV-1 and constitutes a key step before HIV-1 cell entry.

54 uely required for endothelial and epithelial cell entry.

55 s used by herpes simplex virus 1 (HSV-1) for cell entry.

56 me 2 (ACE2) glycoprotein and facilitate host cell entry.

57 the glycoprotein that are required for host-cell entry.

58 roles in mediating viral attachment and host cell entry.

59 nity than SARS-CoV RBD, supporting efficient cell entry.

60 receptor and the serine protease TMPRSS2 for cell entry.

61 apsid proteins that impact the efficiency of cell entry.

62 es human ACE2 as a primary receptor for host cell entry.

63 al importin-betas for distinct steps in host cell entry.

64 domain of the chimpanzee CD4 can prevent SIV cell entry.

65 or productive Gc-induced membrane fusion and cell entry.

66 n lytic potential but only minimally affects cell entry.

67 undergoes substantial refolding during host-cell entry.

68 otective shell, must also disassemble during cell entry.

69 (Env) gp41 subunit plays a critical role in cell entry.

70 V-RBP undergoes a nonclassical route of host-cell entry.

71 d that I2-deficient virions are defective in cell entry.

72 ric assemblies in biological media and their cell entry.

73 t and mouth disease, and plays a key role in cell entry(2).

74 To examine virus-to-cell entry, 49 constructs were incorporated onto vesicul

75 Cell entry, a critical stage in the virus life cycle, co

76 mmune response that involves Th1, CD8, and B cell entry across the blood-brain barrier and virus clea

77 e all antibodies that neutralized epithelial cell entry also inhibited spread in epithelial cells and

78 It reviews fundamental events such as cell entry, amplification, and transcellular movement.

79 y lymphoid environment that impaired naive T cell entry and access to key survival factors.

80 rganizes the host cytoskeleton for efficient cell entry and controls host transcriptional processes t

81 pression and/or RNS generation may restore T-cell entry and could potentially synergize with other im

82 he Fc region of alpha-GA(1) is important for cell entry and efficacy.

83 Cell entry and egress are essential steps in the viral l

84 for both infectious particle production and cell entry and emphasize the exquisite spatiotemporal re

85 ng frames (ORFs) likely associated with host cell entry and exit became fixed in the KRCV-1 genome.

86 rt of fused fluorescent proteins, as well as cell entry and function of a pro-apoptotic peptide.

87 eir targets, the free hormone hypothesis for cell entry and HSP70 for intracellular transport.

88 focuses on coronavirus and influenza A virus cell entry and identifies TEMs as sites of viral proteol

89 trol of replication begins at the onset of T cell entry and IFN-gamma production in the CNS prior to

90 ke domain (MLD) is implicated in Ebola virus cell entry and immune evasion.

91 rate enveloped viruses play crucial roles in cell entry and in large part dictate the spectrum of cel

92 erting enzyme 2 (ACE2) is critical for viral cell entry and infection.

93 Successful cell entry and intoxication by TcdB are known to involve

94 envelope glycoprotein (Env) trimer mediates cell entry and is conformationally dynamic(1-8).

95 of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant target of the immune syst

96 on the hantavirus envelope facilitates host-cell entry and is the primary target of the neutralizing

97 ate future investigations of BASV-G-mediated cell entry and its inhibition in the absence of an infec

98 about the molecular mechanism that mediates cell entry and membrane fusion, although E2 is predicted

99 , the spike (S) glycoprotein, which mediates cell entry and membrane fusion.

100 findings advance our understanding of virus cell entry and open new avenues for curative therapies.

101 ays through TRP effectors to facilitate host cell entry and promote intracellular survival.

102 as fostamatinib and ibrutinib may reduce CLL cell entry and retention by suppressing chemokine-induce

103 ight separable functions of SR-BI during HCV cell entry and reveal a novel role of HVR1 for the prope

104 n, which is the key process for both initial cell entry and subsequent lateral spread of herpes simpl

105 Cell entry and susceptibility studies indicated that thi

106 We have studied mechanisms of host cell entry and the uncoating of incoming viruses as well

107 A, and C57A mutations abolished GPC-mediated cell entry and therefore could not allow for the generat

108 ing to its assembly, stability, functions in cell entry and transcription, and similarities and diffe

109 cate that B virus can utilize gD-independent cell entry and transmission mechanisms, in addition to g

110 (Pentamer) complexes play a key role in HCMV cell entry and tropism.

111 -1) and its fusion peptide are essential for cell entry and vaccine design.

112 ctions of individual host factors during HCV cell entry and viral domains that mediate interactions w

113 ies-specificity of HCV host factor usage for cell entry and virus release has been explored.

114 The viral glycoprotein (GP) facilitates host cell entry and, jointly with cellular interaction partne

115 of HSV-1 and showed that they are capable of cell entry and, like HSV-1, require all four entry glyco

116 lar receptor, AAVR, are key to understanding cell-entry and trafficking with the rigor needed to engi

117 ells, use the same cellular factors for host cell entry, and are comparably susceptible to blockade b

118 ncer and have limited oral absorption, tumor cell entry, and cause bone side effects.

119 ntly, loss or inhibition of CXCR2 improved T cell entry, and combined inhibition of CXCR2 and PD1 in

120 ucial roles in virion assembly, disassembly, cell entry, and infection.

121 ghts into genome packaging, virion assembly, cell entry, and other stages of the viral life cycle.

122 Virus binding to cells, entry, and nucleocapsid uncoating steps were not

123 (SARS)-CoV employ the same receptor for host cell entry, angiotensin-converting enzyme 2 (ACE2), but

124 s), or 4 degrees C, known to attenuate virus cell entry ( approximately 200 sites).

125 tions the phleboviral Gc undergoes upon host cell entry are conserved with otherwise unrelated alpha-

126 all adhesins and effectors involved in host cell entry are differentially encoded in diverse Rickett

127 xt-dependent, and the parameters that impact cell entry are not fully understood, giving rise to vari

128 ndicate that signals controlling mesothelial cell entry are organ specific.

129 Molecular mechanisms of B virus cell entry are poorly understood for both macaques and h

130 These proteins serve as mediators of cell entry as well as modulators of the immune response

131 therogenic conditions to direct inflammatory cell entry at predilection sites of atherosclerosis.

132 he G2A mutation caused a marked reduction of cell entry at the membrane fusion step, and while this m

133 ty but have reported differences in rates of cell entry, autoprocessing, and overall toxicity.

134 Host cell entry begins with activation of the human receptor

135 Cell entry begins with virus spike (S) protein binding t

136 ion, surface attachment, receptor usage, and cell entry between wild-type HCV and a viral mutant lack

137 y titers in mice that neutralize pseudovirus cell entry, block RBD interaction with ACE2, and inhibit

138 Cell entry but not low pH enables this.

139 ve identified host factors essential for AAV cell entry, but no genome-wide screens that address inhi

140 Foot-and-mouth disease virus (FMDV) mediates cell entry by attachment to an integrin receptor, genera

141 ndocytic and the penetrative routes for host cell entry by intracellular pathogens.

142 By contrast, MYO7B regulates alpha-Syn PFF cell entry by maintaining a plasma membrane-associated a

143 Current understanding of cell entry by mammalian reovirus (MRV) virions and infec

144 n studies revealed that F3406 inhibited LCMV cell entry by specifically interfering with the pH-depen

145 in, E, promotes membrane fusion during viral cell entry by undergoing a low-pH triggered conformation

146 rticle tracking for identifying key steps in cell entry by viruses.

147 D-II/D-III is involved in formation of the B cell entry complex by binding to gp42.

148 L/gO and Pentamer forming mutually exclusive cell entry complexes and reveal the overall location of

149 d a trio of fusion protein subunits play the cell entry concert of parainfluenza viruses.

150 pentameric complex (PC)-mediated epithelial cell entry decrease CMV infection after HCT, samples wer

151 D1 L45 loop interacts with the mycobacterial cell entry domain of TGD2.

152 , which contains an array of seven mammalian cell entry domains.

153 cells were indistinguishable with respect to cell-entry efficiency, significantly higher numbers of A

154 s challenged by our limited understanding of cell entry, especially at the step of membrane fusion.

155 n, we identified glypican 5 as a common host cell entry factor for hepatitis B and delta viruses.

156 idermal growth factor receptor (EGFR)-a host cell entry factor used by several viruses, including hep

157 e findings uncover this distinct set of host cell entry factors in LUJV infection and are attractive

158 eins and infect cells by using at least four cell entry factors.

159 Our data reveal a novel mechanism of cell entry for a nonenveloped virus and highlight mechan

160 also shown to have a different mechanism of cell entry from other C3 toxins.

161 In addition, the requirement for gp350 for T-cell entry has implications for EBV vaccine studies curr

162 have been identified, and the mechanisms of cell entry have been elucidated.

163 Upon cell entry, herpesviruses deliver a multitude of premade

164 After cell entry, HIV undergoes rapid transport toward the nuc

165 es provide insights into the receptor usage, cell entry, host cell infectivity and animal origin of 2

166 The outer capsid participates in cell entry: (i) sigma3 is degraded to generate the infec

167 both endocytic and nonendocytic pathways for cell entry in contact exposure, whereas NEP delivery of

168 hemotherapeutic treatment is critical for MM cell entry in premature senescence and is required for t

169 razine used to treat migraine, inhibited HCV cell entry in vitro and in vivo in a genotype-dependent

170 The process of non-enveloped virus cell entry, in comparison, remains poorly defined, parti

171 n, which has been associated with SARS-CoV-2 cell entry, in the nasal epithelium of children vs adult

172 Drugs that can block viral attachment and cell entry independent of antigenic evolution or drug re

173 E2 and a number of animal-ACE2 orthologs for cell entry, indicating risks of spillover of these virus

174 es structural transformation between mature, cell-entry intermediate (A-particle) and empty forms thr

175 pansion of the capsid, to form an infectious cell-entry intermediate particle that sediments at 135S.

176 restrains PDAC cell growth through mediating cell entry into a quiescent state.

177 ial membrane disruption by PHMB, we observed cell entry into a range of bacterial species, and treate

178 lloproteinases, which together facilitated T cell entry into CNS parenchyma.

179 Although T cell entry into effector sites is key to inflammation, t

180 uman T cell transendothelial migration and T cell entry into LNs were suppressed by Lama5 through the

181 Although pyruvate delays cell entry into S phase, pyruvate represses histone gene

182 inflamed tissues, without affecting naive T cell entry into secondary lymphoid organs.

183 regulation is a prerequisite for activated T cell entry into the cell cycle.

184 ions as the blood-CSF barrier to gate immune cell entry into the central nervous system.

185 produced by ALL cells in mediating leukemia-cell entry into the CNS and leptomeningeal infiltration

186 r mechanisms and pathways mediating leukemia-cell entry into the CNS need to be understood to identif

187 In this study, we analyzed leukemia-cell entry into the CNS using a primograft ALL mouse mod

188 cells, although a modest reduction in immune cell entry into the CNS was observed.

189 Thus, we identified a mechanism of ALL-cell entry into the CNS, which by targeting VEGF signali

190 eting Lama5 promoted antigen-specific CD4+ T cell entry into the CR through HEVs, suppressed T cell a

191 We visualized WT1(+) mesothelial cell entry into the lung by live imaging and identified

192 deficiency decreases the average rate of Th1 cell entry into the lung parenchyma by half, while CX3CR

193 t lymph node lymphatic sinuses control tumor cell entry into the lymph node, which requires active tu

194 affinity for antigen does not control CD4+ T-cell entry into the primary immune response, as a divers

195 mmune evasion in MCC may be restriction of T-cell entry into the tumor.

196 Immune cell entry into the virally infected CNS is vital for pr

197 adaptive immune system, and regulation of T cell entry into tissues is an effective therapy in autoi

198 l antitumor immunity is thought to require T cell entry into tumors, though mechanisms regulating thi

199 ll cycle arrest in fission yeast by delaying cells entry into S phase.

200 In most cells, entry into the cell cycle allows centrioles to un

201 Hepatitis C virus (HCV) cell entry is a complex, multistep process requiring num

202 Use of hTfR1 for host cell entry is a feature shared by pathogenic NWAs.

203 y emerging African HNVs at the stage of host-cell entry is a key parameter when considering the poten

204 HIV-1 cell entry is initiated by the interaction of the viral

205 Paramyxovirus cell entry is mediated by the fusion protein, F, in resp

206 Arenavirus cell entry is mediated by the viral glycoprotein (GP) co

207 HCV cell entry is SR-BI dependent irrespective of the presen

208 MCPyV cell entry is unique among members of the polyomavirus f

209 hat mediates ISVP-to-ISVP* conversion during cell entry is unknown.

210 nvolved in magnesium transport (NIPAL1), EBV cell entry (ITGB6), modulation of EBV infection (BCL2L12

211 ubunit, is a critical component of the virus-cell entry machinery.

212 d as an inhibitor of hepatitis C virus (HCV) cell entry, making it the only known component of human

213 livary antibodies that neutralize epithelial cell entry may be especially important for preventing or

214 One example of this is the mammalian cell entry (mce) locus, which has been characterised in

215 We report that members of the mammalian cell entry (MCE) protein family form hexameric assemblie

216 erspectives on the comprehension of the HCMV cell entry mechanism and tropism.

217 ovide a basis for future work to dissect the cell entry mechanism of GLV into a "primitive" (early-br

218 eceptors, indicating that this virus employs cell entry mechanisms distinct from those of classical i

219 Our findings have identified key cell entry mechanisms of SARS-CoV-2.

220 EIPA also inhibited cell entry mediated by the glycoproteins of the HF arena

221 e placenta minimally expresses the canonical cell-entry mediators for SARS-CoV-2.

222 Additionally, during cell entry, mu1 undergoes structural rearrangements that

223 red yet be poised to bind receptor, initiate cell entry, navigate the cellular milieu, and release th

224 MeV attachment protein hemagglutinin (H) and cell entry, nectin-4 homodimerization, and heterodimeriz

225 ed transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity

226 PepB2 mediated the cell entry of a wide variety of molecules including dext

227 Concepts about cell entry of AdV build on strong foundations from molec

228 outer capsid proteins VP2 and VP5 coordinate cell entry of BTV.

229 Cell entry of HCV and other pathogens is mediated by tig

230 Moreover, epithelial cell entry of HIV-1 was positively correlated with invas

231 sicular bodies (MVBs) and the endocytic host cell entry of influenza A virus.

232 ospholipase gamma1 (PLC-gamma1) in mediating cell entry of influenza virus H1N1 but not H3N2 subtype.

233 acological and genetic studies revealed that cell entry of LCMV in A549 cells depended on actin remod

234 re innate effector proteins restricting host cell entry of many enveloped viruses, including HCV.

235 ycoprotein D (gD) plays an essential role in cell entry of many simplexviruses.

236 CD4 polymorphisms also reduced Env-mediated cell entry of monkey SIVs, which was dependent on at lea

237 Analogous mechanisms may support cell entry of other viruses that utilize nectins or othe

238 Here we investigate the receptor usage and cell entry of PEDV.

239 nge of domestic and wild animals can support cell entry of SARS-CoV-2 and three related coronaviruses

240 Third, unlike SARS-CoV, cell entry of SARS-CoV-2 is preactivated by proprotein c

241 rabbits, and pangolins, were able to support cell entry of SARS-CoV-2, suggesting that these species

242 Cell entry of SARS-CoV-2, the novel coronavirus causing

243 ed the expression of receptors implicated in cell entry of several enveloped viruses including ZIKV a

244 ment of anti-toxin strategies for preventing cell entry of the toxin.

245 egmatis contains 6 homologous mce (mammalian cell entry) operons which have been proposed to encode A

246 and HSV-2 glycoproteins are involved in HSV cell entry or are required for viral spread in animals,

247 ea pigs, but it did not significantly affect cell entry or viral growth in cell culture.

248 nvolved in a myriad of functions during host cell entry, pathogenesis, and antigenicity for other mem

249 ltogether, these data indicate a unique host-cell entry pathway for this emerging and potentially pat

250 and Pak1, suggesting a macropinocytosis-like cell entry pathway.

251 Our understanding of the complex cell entry pathways would greatly benefit from a compreh

252 hogen, rather than a direct role in the host cell entry process itself.

253 A better understanding of these cell entry processes will not only aid in nanomaterial a

254 CXCL16 likely plays a major role in EAV host cell entry processes, possibly acting as a primary recep

255 Owing to the challenges of cell entry, protein-based therapies have so far been res

256 mlo12 triple mutants exhibited reduced host cell entry rates by Colletotrichum higginsianum, a funga

257 L16) to be a candidate molecule and possible cell entry receptor for equine arteritis virus (EAV).

258 ngiotensin converting enzyme-2 (ACE2) as its cell entry receptor.

259 Antibodies (Abs) against host cell entry receptors have been shown to inhibit HCV infe

260 rophoblasts expressed multiple putative ZIKV cell entry receptors, and cellular function and differen

261 I) molecules of multiple species function as cell-entry receptors for the haemagglutinin-like H18 pro

262 In the current study, we examined a putative cell entry region of TcdB (amino acid residues 1753-1851

263 Membrane fusion for morbillivirus cell entry relies on critical interactions between the v

264 However, the mechanistic basis for M cell entry remains undefined.

265 n how changes in ACE2 promoted by SARS-CoV-2 cell entry result in the development of the three most s

266 Rotavirus cell entry results in loss of an outer protein layer and

267 neurotropic infection used to study CD8(+) T cell entry, retention, and function in the brain.

268 evade Pgp export and release free PTX after cell entry, shows efficacy against PTX-resistant ovarian

269 During cell entry, sigma3 is degraded by luminal or intracellul

270 ns to catalyze membrane fusion, an essential cell entry step.

271 but no specific protein machinery to mediate cell entry, such as the fiber complexes in IMNV, could b

272 uding the binding site used by the toxin for cell entry, suggesting a possible explanation for the me

273 plasma, and chemokine coreceptor usages for cell entry, suggesting similar abilities to initiate inf

274 n magnitude than the changes associated with cell entry, suggesting that this VHH traps the virus in

275 r neutralizing fibroblast but not epithelial cell entry suggests that polymorphisms external to certa

276 During cell entry, the cleaved Fs rearrange from prefusion trim

277 After cell entry, the core disassembles in a process termed un

278 Following cell entry, the RNA genome of HIV-1 is reverse transcrib

279 glycoproteins Gn and Gc are involved in host cell entry, the specific cellular receptors of SBV are c

280 Upon host cell entry, the viral genome is translated on endoplasmi

281 fect between these two NP types during their cell entry through receptor-mediated macropinocytosis.

282 Cell entry times into microconstrictions decrease with i

283 increased by genetic means in all supporting cells, entry to the cell cycle and differentiation to ha

284 refore, we sought to elucidate mechanisms of cell entry, trafficking, and pathogenic action of AMA in

285 across the periplasm, such as MCE (Mammalian Cell Entry) transporters, have not been well characteriz

286 emic clearance by the liver, and facilitates cell entry via a non-endocytic pathway.

287 Specifically, immune cell entry was largely considered to be pathological or

288 pparently poor capacity for supporting virus cell entry, we analyzed the HAdv5-FVII complex by using

289 undergo conformational changes required for cell entry, we characterized viruses with mutations engi

290 to those found in infectious virions before cell entry were observed upon mutation of a single amino

291 arable to Jc1 HCVcc particles, used CD81 for cell entry, were associated with ApoE and could be neutr

292 he second fusion-activating cleavages during cell entry, whereas the more rigid uncleaved MERS viruse

293 espiratory syndrome, including the system of cell entry, which is triggered by binding of the viral s

294 of the viral and host determinants of CHIKV cell entry, which may foster development of new antivira

295 ially allow SARS-CoV-2 to maintain efficient cell entry while evading immune surveillance.

296 In contrast, oxidants promote cytosolic cell entry with an efficiency proportional to the level

297 apsid reported to be principally involved in cell entry with the corresponding sequences from HAdV-5.

298 lations combine one variant's proficiency at cell entry with the other's proficiency at cell exit.

299 mentation of Ebola virus glycoprotein-driven cell entry (with IC(50) values down to 95 pM), but only

300 oteins Gn and Gc mediate virion assembly and cell entry, with Gc driving fusion of viral and endosoma