ライフサイエンスコーパス: cell homeostasis

1 phasizes its importance for maintaining host cell homeostasis.

2 function is crucial for the maintenance of T cell homeostasis.

3 Autophagy is crucial for maintaining cell homeostasis.

4 n how S1P1 signaling regulates Th17 and Treg cell homeostasis.

5 -binding protein (GABP) in T cells impairs T-cell homeostasis.

6 ophagic degradation of Rph1 is important for cell homeostasis.

7 way annotations indicative of roles in basic cell homeostasis.

8 r and its receptor, KIT, are central to mast-cell homeostasis.

9 ocyte egress but contributes to peripheral T cell homeostasis.

10 ion of cellular components, is essential for cell homeostasis.

11 going requirement of LUBAC activity for Treg cell homeostasis.

12 ver, and spleen, thereby maintaining myeloid cell homeostasis.

13 regulator of naive, memory, and regulatory T cell homeostasis.

14 ploid yeast, is a key regulator of aneuploid cell homeostasis.

15 ion of CLV3 levels that is critical for stem cell homeostasis.

16 S expression domains to maintain floral stem-cell homeostasis.

17 merization and subcellular localization in T-cell homeostasis.

18 ndent DCs in the maintenance of intestinal T cell homeostasis.

19 regulator of actin dynamics important for T-cell homeostasis.

20 hose levels are tightly controlled to secure cell homeostasis.

21 plete function in DNA repair and tissue stem cell homeostasis.

22 egulatory T (Treg)-cell development and Treg cell homeostasis.

23 global change of gene expression to maintain cell homeostasis.

24 ing a generalized role for Notch in innate T cell homeostasis.

25 e implicated in Treg and follicular helper T cell homeostasis.

26 hen ISR signaling is insufficient to restore cell homeostasis.

27 nhibitory NK cell receptors contribute to NK cell homeostasis.

28 e miR-142 target through which it controls B-cell homeostasis.

29 development and neonatal epithelial and mast cell homeostasis.

30 gulated either T-bet or GATA-3 to maintain T cell homeostasis.

31 regulatory mechanisms controlling satellite cell homeostasis.

32 ficiency on signaling pathways involved in B cell homeostasis.

33 conserved requirement for IL-33 in VAT-Treg cell homeostasis.

34 cating an important role of the S1P2 in beta-cell homeostasis.

35 opmental pathways and a role for E4BP4 in NK cell homeostasis.

36 and collectively influence intestinal immune cell homeostasis.

37 nd ILCs in the regulation of intestinal Th17 cell homeostasis.

38 fy a novel molecular pathway that controls T-cell homeostasis.

39 mitophagy is an essential process to ensure cell homeostasis.

40 e detailed mechanistic understanding of stem cell homeostasis.

41 al dynamics is crucial for the regulation of cell homeostasis.

42 a tumor suppressor to maintain hematopoietic cell homeostasis.

43 ng-lived proteins and organelles to maintain cell homeostasis.

44 g of metabolic regulation in intestinal stem cell homeostasis.

45 proteins in controlling apoptosis in normal cell homeostasis.

46 mice and is crucial for the maintenance of B cell homeostasis.

47 icine due to its essential functions in stem cell homeostasis.

48 teraction may regulate pancreatic epithelial cell homeostasis.

49 nce of intracellular signaling to maintain T cell homeostasis.

50 plasma membrane in every cell, are vital for cell homeostasis.

51 lineage specification and peripheral naive T cell homeostasis.

52 the thymus in early life to regulate PLZF(+) cell homeostasis.

53 human diseases associated with altered stem cell homeostasis.

54 suggesting its role in the regulation of NK cell homeostasis.

55 intain the health of mitochondria and ensure cell homeostasis.

56 ructure are tightly connected to achieve the cell homeostasis.

57 trict adenoma initiation by controlling stem cell homeostasis.

58 lysosome biogenesis, is critical to maintain cell homeostasis.

59 f myocardial extracellular volume and immune cell homeostasis.

60 rols effector CD4(+) cell responses and Treg cell homeostasis.

61 ine-tuning hematopoietic stem and progenitor cell homeostasis.

62 serve as scaffolds to support and regulate T cell homeostasis.

63 satility is required to maintain endothelial cell homeostasis.

64 tors of autophagy, lysosomal biogenesis, and cell homeostasis.

65 erely disrupts B cell trafficking and immune cell homeostasis.

66 3(+) stromal cells play a role in epithelial cell homeostasis.

67 ed for a tightly balanced mTOR pathway in NK cell homeostasis.

68 restored disturbances in peripheral B- and T-cell homeostasis.

69 ontributing to the regulation of neural stem cell homeostasis.

70 IL-15, which is important for T cell and NK cell homeostasis.

71 re reportedly involved in the maintenance of cell homeostasis.

72 mutations while preserving thymic epithelial cell homeostasis.

73 normal peripheral immune response and immune cell homeostasis.

74 hagy is a major regulator of pancreatic beta cell homeostasis.

75 autophagy and cell metabolism in maintaining cell homeostasis.

76 are required for optimal CD4(+) and CD8(+) T cell homeostasis, activation, and effector development i

77 antly activated B cells and restore normal B-cell homeostasis after allogeneic stem cell transplantat

78 However, the mechanisms which govern iNKT cell homeostasis after thymic emigration are incompletel

79 d ligand binding result in disrupted T and B cell homeostasis and a complex immune dysregulation synd

80 ncover novel mechanisms contributing to beta-cell homeostasis and a resource for therapeutic target a

81 We assessed Treg and CD8(+) T-cell homeostasis and activation during the changing syst

82 post-transcriptional control during CD8(+) T cell homeostasis and activation, and focus on the crosst

83 Lyn-dependent signaling pathways regulate B cell homeostasis and activation, which in concert with B

84 t stromal cells play in orchestrating immune cell homeostasis and adaptive immunity.

85 mocyte egress is a critical determinant of T cell homeostasis and adaptive immunity.

86 microbiota composition controls intestinal T cell homeostasis and alters T cell responses of mice in

87 ass of regulatory molecules that finely tune cell homeostasis and are deregulated in disease states,

88 Rag1(-/-) mice restored Mdr1-deficient Teff cell homeostasis and attenuated ileitis.

89 e-6-phosphate transporter mutation on immune cell homeostasis and CD4(+) T cell functions.

90 nciple for histone modification, during both cell homeostasis and cell death.

91 e of Wnt signaling for adult intestinal stem cell homeostasis and colorectal cancer, relatively littl

92 y regulated protease complex fundamental for cell homeostasis and controlled cell cycle progression.

93 Egr)-2 is important for the maintenance of T cell homeostasis and controls the development of autoimm

94 ' protein METTL3 in mouse T cells disrupts T cell homeostasis and differentiation.

95 ynamics and regulation of hematopoietic stem cell homeostasis and differentiation.

96 ion within the murine gut that alters immune cell homeostasis and disease susceptibility.

97 -protein interactions play a pivotal role in cell homeostasis and disease, but current approaches to

98 e of lipid peroxyl radical production during cell homeostasis and disease.

99 -digestion pathway with fundamental roles in cell homeostasis and diseases.

100 /SIV target cells, it also supports NK and T cell homeostasis and effector activity, potentially bene

101 d identifies a subset of FRCs that control B cell homeostasis and follicle identity.

102 gnals were dispensable for steady-state Treg cell homeostasis and for Treg cell suppression of T cell

103 ta support a critical role for DOCK8 in Treg cell homeostasis and function and the enforcement of per

104 mechanisms that regulate haematopoietic stem cell homeostasis and function remain largely unknown.

105 w these regulators synergize to control Treg cell homeostasis and function remains unclear.

106 ized as an important mediator of endothelial cell homeostasis and function that impacts upon vascular

107 pected to interfere with T regulatory (Treg) cell homeostasis and function, recently, substantial con

108 ays that are crucial for stem and progenitor cell homeostasis and function, such as the Notch, WNT, H

109 nase 1 (TAK1) is important in satellite stem cell homeostasis and function.

110 BAFFR and TACI on B cells is critical for B cell homeostasis and function.

111 ablation of Vps34 had a profound impact on T cell homeostasis and function.

112 hagy) is emerging as a critical regulator of cell homeostasis and function.

113 a pleiotropic cytokine that regulates immune cell homeostasis and has been used to treat a range of d

114 f the RANKL-RANK axis in the regulation of B cell homeostasis and highlight an unexpected link betwee

115 extensive genetic networks that control stem cell homeostasis and highlight the intricate regulation

116 Despite their fundamental importance to cell homeostasis and human physiology, structural inform

117 P5 as a key regulator of basal prostate stem cell homeostasis and identifies a potential therapeutic

118 has a nonredundant role in the control of T-cell homeostasis and immunity.

119 s that is mandatory for the maintenance of T cell homeostasis and immunological self-tolerance later

120 as in autoimmune disease, can disturb immune cell homeostasis and induce the expansion of normally ra

121 vere inflammation and correlated with Paneth cell homeostasis and inflammation.

122 hat dysregulated IEC gene expression, Paneth cell homeostasis and intestinal barrier function were la

123 oles in embryonic development and adult stem cell homeostasis and is altered in human cancer.

124 cal for lung development and lung epithelial cell homeostasis and is predicted to target fibrotic gen

125 lation of this pathway can negatively affect cell homeostasis and is responsible for the development

126 olecule is an important regulator of naive T cell homeostasis and it has been linked to immune defici

127 ts into how ROS signaling can influence stem cell homeostasis and lineage commitment, and discuss the

128 plication without causing a loss of CD4(+) T cell homeostasis and lymphoid tissue damage that lead to

129 ell survival and can thereby contribute to B-cell homeostasis and lymphomagenesis.

130 ene playing key roles in haematopoietic stem cell homeostasis and malignant haematopoiesis.

131 illations and analyze their origins in guard cell homeostasis and membrane transport.

132 T cell activation to encompass both naive T cell homeostasis and models of weak activation, such as

133 5b (STAT5b) deficiency have impairment in T-cell homeostasis and natural killer (NK) cells which lea

134 These data demonstrate that CIC maintains T-cell homeostasis and negatively regulates TFH cell devel

135 ckdown in mice results in altered epithelial cell homeostasis and neonatal death.

136 n the role of cell death in maintenance of T-cell homeostasis and outline novel therapeutic strategie

137 al degradation machinery that is involved in cell homeostasis and pathogenicity.

138 he importance of the thymus in human naive T cell homeostasis and premature aging.

139 on of humoral immunity via their impact on B cell homeostasis and proliferation upon activation.

140 However, the mechanisms regulating DN T cell homeostasis and responses to external danger signal

141 post-transcriptional mechanisms enable stem cell homeostasis and responsiveness to developmental cue

142 hogenesis and reveals a novel mechanism of T cell homeostasis and signal-dependent induction of mRNA

143 scription factors are critical regulators of cell homeostasis and steer cell death, differentiation a

144 ects DC development, indirectly modulating T cell homeostasis and supporting T reg cell expansion.

145 of proteasome function in maintenance of AT2 cell homeostasis and supports the need to further invest

146 er, the molecular mechanisms underlying Treg cell homeostasis and suppressive function are still not

147 he ubiquitin-proteasome system is central to cell homeostasis and survival.

148 ggest that Lis1 plays an important role in T cell homeostasis and the generation of memory T lymphocy

149 nant cells is also known to be involved in T cell homeostasis and the response to viral infections an

150 m-bone marrow communication in hematopoietic cell homeostasis and their impact on hypertension pathop

151 , both of which are critical aspects of stem cell homeostasis and tightly linked to their functional

152 -only protein, was shown to play a role in B-cell homeostasis and to mediate cell death in response t

153 e ligand/receptor axis controls (progenitor) cell homeostasis and trafficking.

154 -mediated histone acetylation in maintaining cell homeostasis and tumor development.

155 rtant implications in our understanding stem cell homeostasis and tumorigenesis.

156 ays important roles in nutrient utilization, cell homeostasis and virulence.

157 Protein synthesis is crucial for regulating cell homeostasis and, when unrestricted, it can lead to

158 hesin silencing in vivo rapidly altered stem cells homeostasis and myelopoiesis.

159 on the development of immune responses, mast cell homeostasis, and anaphylactic food allergy was asse

160 CR signaling strength for controlling CSR, B cell homeostasis, and B cell-mediated disorders.

161 he regulation of energy balance, tissue/stem cell homeostasis, and disease pathogenesis.

162 IL system is best known for its control of B cell homeostasis, and it is a target of therapeutic inte

163 oles in protective immunity, control of mast cell homeostasis, and its more recently revealed immunom

164 -7 (IL-7) is fundamental for thymopoiesis, T-cell homeostasis, and survival of mature T cells, which

165 ated whether apoptosis pathways regulating T-cell homeostasis are perturbed in CD28(null) T cells in

166 atory pathways, typically involved in immune cell homeostasis, are co-opted by cancer cells to thwart

167 ion-inducing ligand (APRIL), which control B cell homeostasis, are therapeutic targets in autoimmune

168 te ROS sensing into decisions regarding stem cell homeostasis, are unclear.

169 s CD80/CD86, signals needed for regulatory T cell homeostasis, are upregulated less on NOD cDCs.

170 d in several cancers; however, their role in cell homeostasis as well as in cellular transformation r

171 gomeric protein complexes that contribute to cell homeostasis as well as virulence regulation in bact

172 mediated receptors likely impacts intestinal cell homeostasis, as the cleavage of multiple intestinal

173 severe defects in lymphoid development and T cell homeostasis associated with impaired PI3K signaling

174 w commensal microbiota contributes to immune cell homeostasis at barrier surfaces is poorly understoo

175 one more hierarchical layer regulating stem cell homeostasis beneath the stem cell-dermal papilla-ba

176 Blimp1 is required to control Treg and Teff cells homeostasis but, unexpectedly, it is dispensable t

177 Mitophagy has a pivotal role in cell homeostasis, but its contribution to macrophage fun

178 BAFF is a key cytokine in B cell homeostasis, but its potential contribution to the

179 n unappreciated mechanism for restoring stem cell homeostasis, but one with some associated risk in a

180 d and receptor paralogs is critical for stem cell homeostasis, but that diverse genetic mechanisms bu

181 ask of controlling cutaneous epithelial stem cell homeostasis by balancing TGF-beta-mediated growth-i

182 d control intestinal stem cell and secretory cell homeostasis by downregulation of multiple target mR

183 ently expressed viral miRNAs manipulate stem cell homeostasis by inducing secretion of TGF-beta while

184 citZ transcript in order to maintain proper cell homeostasis by preventing the overaccumulation of c

185 B7-H4 plays a key role in maintaining T-cell homeostasis by reducing T-cell proliferation and cy

186 Thus, ARF1 can regulate Drosophila blood cell homeostasis by regulating Asrij endocytic function.

187 rotein, has emerged as a regulator of immune cell homeostasis by shaping the fate of myeloid and lymp

188 ovide an insight in regulation of adult stem cells homeostasis by two major pathways with opposing fu

189 ive syndrome (ALPS) is a human disorder of T cell homeostasis caused by mutations that impair FAS-med

190 ll-specific ablation of TRAF3 impaired CD4 T cell homeostasis, characterized by an increase in the Th

191 nic immune activation and dysregulation of T cell homeostasis correlate with reactivation of LTBI.

192 rophil differentiation and restoring myeloid cell homeostasis could limit the formation of survival n

193 known pathway of regulation of innate-like T-cell homeostasis depending on XIAP and PLZF.

194 s a profound NK lineage-intrinsic role in NK cell homeostasis, development, education, and cytokine p

195 The loss of acinar cell homeostasis, differentiation, and identity is direc

196 Moreover, T cell homeostasis driven by cytokine or TCR-mediated sign

197 une system employs ATLOs to organize aorta T cell homeostasis during aging and that VSMC-LTbetaRs par

198 xpressed transcription factors important for cell homeostasis during dynamic oxygen levels.

199 nisms of telomeric DDR and its role in CD4 T-cell homeostasis during HIV infection.

200 ecular mechanisms of telomeric DDR and CD4 T-cell homeostasis during HIV infection.IMPORTANCE The hal

201 R4(+)/IgG(+) PCs might play a role in immune cell homeostasis during inflammatory processes of the gu

202 ights into a critical mechanism in satellite cell homeostasis during muscle regeneration could help i

203 pivotal role in the regulation of satellite cell homeostasis during regenerative myogenesis.

204 Mammalian cell homeostasis during starvation depends on initiation

205 pathways function concurrently to regulate T cell homeostasis during the early stages of immune respo

206 Ultimately, CD4(+) memory T-cell homeostasis fails and critical effector populations

207 munosuppression; however, a restoration of T cell homeostasis following depletion leads to increased

208 ry for maintaining naive CD4(+) and CD8(+) T cell homeostasis for subsequent optimal T cell expansion

209 ficient in coronin 1, a regulator of naive T cell homeostasis, fully retained allografts while mainta

210 rtance for peripheral T cell tolerance and T cell homeostasis has been studied intensively.

211 role of endothelial cells in supporting beta-cell homeostasis has been vastly investigated, the role

212 ption factors involved in hematopoietic stem cell homeostasis, hematopoiesis, and lymphocyte differen

213 on of inflammatory cytokines and disturbed T-cell homeostasis, however, the precise mechanism of this

214 pancreatic beta-cells but also regulate beta-cell homeostasis in a divergent manner.

215 er of lipids onto CD1d, regulates liver iNKT cell homeostasis in a manner dependent on hepatocyte CD1

216 b altered MP Treg and MP CD4(+) and CD8(+) T cell homeostasis in a manner similar to that observed wi

217 ich cholesterol accumulation can influence T cell homeostasis in atherosclerosis.

218 ells, virus persistence and CMV-associated T cell homeostasis in blood, lymphoid, mucosal and secreto

219 e-B cells, we propose that modification of B cell homeostasis in deficient animals was caused by "wea

220 these effects may adversely affect CD4(+) T cell homeostasis in HIV patients.

221 th distinct and joint influence upon blood T cell homeostasis in humans.

222 a novel role of vitamin A in regulating iNKT cell homeostasis in many tissues throughout the body.

223 d its closest homolog, AGO10, maintains stem cell homeostasis in meristems by sequestration of miR165

224 en implicated as a key regulator of T and NK cell homeostasis in multiple systems; however, its speci

225 icipates in signaling pathways essential for cell homeostasis in multiple tissues, however, its funct

226 generic and robust mechanism to support stem cell homeostasis in open, or facultative, niche environm

227 ing the epidermis-derived signal to the stem cell homeostasis in plants.

228 athogenesis responses and for maintenance of cell homeostasis in short-day conditions.

229 ts in Th17 cell cytokine expression and Treg cell homeostasis in the absence of Mir155 could be parti

230 indicate that Ikaros is required to limit B1 cell homeostasis in the adult.

231 d regenerative thymopoiesis and peripheral T-cell homeostasis in the adulthood.

232 We further show how apoptosis regulates germ cell homeostasis in the gonad, and propose a role for in

233 ate sensor AIM2 regulates microbial and stem cell homeostasis in the gut to protect against colorecta

234 s play a critical role in the maintenance of cell homeostasis in the presence of disturbances and unc

235 nfiltrating monocytes in maintaining myeloid cell homeostasis in the retina following AMD-relevant RP

236 Although IL-15 is essential for NK cell homeostasis in vivo, it is commonly used at supraph

237 largely dispensable for mouse adult somatic cell homeostasis in vivo, it plays a critical role in B-

238 were high in IL-6 and IL-10 and disrupted T cell homeostasis in vivo.

239 Interleukin-33 (IL-33) regulated muscle Treg cell homeostasis in young mice, and its administration t

240 Despite the significance of the UPR for cell homeostasis, in plants the regulatory circuitry und

241 he role of IL-7, a key cytokine regulating T-cell homeostasis, in suppressor capacity of Treg.

242 cific loss of 5-hmC in genes regulating stem cell homeostasis, including MBD1, RTN1, STRN4, PRKD2, AK

243 ins are important regulators of gammadelta T cell homeostasis, inhibiting the survival of IL-17-produ

244 generally, Notch regulation of innate-like T cell homeostasis involves both cell-intrinsic and -extri

245 However, how stem cell homeostasis is achieved in environments where cells

246 We propose that stem cell homeostasis is achieved through competition for a l

247 der certain pathological conditions, myeloid cell homeostasis is altered and immature forms of these

248 lthough ample evidence indicates that immune cell homeostasis is an important prognostic outcome dete

249 Maintenance of appropriate T-cell homeostasis is essential to promote protective immu

250 How T cell homeostasis is maintained in barrier tissues is sti

251 ole in carcinogenesis, depending on how stem cell homeostasis is maintained.

252 In the periphery, B cell homeostasis is not affected, but survivin-deficient

253 ss, the role of these pathways in adult beta-cell homeostasis is not well defined.

254 lectively, these results demonstrate that NK cell homeostasis is obligatorily dependent upon IL-15 in

255 Because B-cell homeostasis is perturbed in patients with WAS and r

256 Notably, gingival gammadeltaT cell homeostasis is regulated by the microbiota as the r

257 However, basal stem/progenitor cell homeostasis is still poorly understood.

258 Essential for eukaryotic cell homeostasis, it plays central roles in bone remodel

259 disrupts basal Stat1 signaling and alters T-cell homeostasis, leading to impaired progenitor mainten

260 dox-sensitive protein with multiple roles in cell homeostasis, levels of which are altered in patient

261 anscription factor has a fundamental role in cell homeostasis maintenance as one of the master regula

262 To assess B cell function in promoting T cell homeostasis, mature B cells were either acutely or

263 endent changes in factors supporting naive T cells homeostasis may also be involved.

264 In addition to maintaining cell homeostasis, MCS formation recently emerged as a me

265 They contribute to cell homeostasis, morphogenesis, and pathogen defense.

266 deleted genes, playing diverse functions in cell homeostasis, offers a rich repertoire of pharmacolo

267 Calcium fluorometry is critical to determine cell homeostasis or to reveal communication patterns in

268 Autophagy is critical for beta-cell homeostasis, particularly under conditions of stres

269 ral competition, an emerging feature of stem cell homeostasis, posits that individual stem cells can

270 n, indicating a crucial role for Blimp1 in T cell homeostasis regulation.

271 ion of epidermal Wnt secretion in epithelial cell homeostasis remains poorly understood.

272 cial functions in food digestion, and acinar cell homeostasis required for secretion of digestive enz

273 We report that hair cell homeostasis requires a specific sub-branch of the D

274 Maintenance of myeloid cell homeostasis requires continuous turnover of phagocy

275 Eukaryotic cell homeostasis requires transfer of cellular component

276 ith which to explore the links between guard cell homeostasis, stomatal dynamics, and foliar transpir

277 cs, a non-standard theoretical approach to T cell homeostasis that accounts for clone diversity as ar

278 ity of the RELB and NF-kappaB2 subunits in B cell homeostasis that cannot be compensated for by the c

279 genous netrin-1 plays a role in NG2(+) glial cell homeostasis that is distinct from its role in myeli

280 Although a critical player in naive T cell homeostasis, the ability of VISTA to restrain naive

281 l epithelial cells, and which impairs immune cell homeostasis, thereby promoting MIA-CID development.

282 protein in modulating intestinal epithelial cell homeostasis through ADAM17-mediated HB-EGF release,

283 unfolded protein response, UPR, to regulate cell homeostasis through both gene expression and protei

284 n the skin that contribute to skin dendritic cell homeostasis through chemokine production.

285 for various cellular processes and maintain cell homeostasis through cross talk.

286 erations in lipid metabolism may affect iNKT cell homeostasis through effects on CD1d-associated lipi

287 s an important role in maintaining endocrine cell homeostasis through feedback mechanisms that govern

288 s, often working in networks, is to maintain cell homeostasis through interaction with substrate prot

289 alpha-helical cytokine that regulates immune cell homeostasis through its recruitment to a high-affin

290 s tTreg cell development and peripheral Treg cell homeostasis through the regulation of BIC/microRNA

291 c reticulum (ER) and the nucleus to maintain cell homeostasis via proper folding of proteins.

292 onment within granules is important for mast cell homeostasis, we sought to evaluate the effects of o

293 ffector T cell phenotypes and dysregulated T cell homeostasis, were likely mediators of reactivation

294 tions in Evc2 affect dental mesenchymal stem cell homeostasis, which further leads to hypomorphic ena

295 hronic immune activation and disruption of T-cell homeostasis, which impact the rate of disease progr

296 omotes cholesterol accumulation and alters T cell homeostasis, which may contribute to progression of

297 itical role in maintaining pancreatic acinar cell homeostasis, whose dysregulation promotes pancreati

298 protein kinase CLAVATA1 (CLV1) maintain stem cell homeostasis within a deeply conserved negative feed

299 an integral role in the maintenance of stem cell homeostasis within multiple stem cell systems, as a

300 icated in human cardiovascular disease and B-cell homeostasis, yet the role of B-1 cell CXCR4 in regu