ライフサイエンスコーパス: cell line

1 proteomic analysis of a kidney-derived HLRCC cell line.

2 from the enzalutamide-resistant (Enz-R) VCaP cell line.

3 ed the binding to 53% +/- 3% of the parental cell line.

4 nd toxicity in a human neuroblastoma SH-SY5Y cell line.

5 led to estimates of low-mM ribose in a HeLa cell line.

6 e than 8000 genomic interactions in each PEL cell line.

7 heir metastatic potential) in PANC-1, a PDAC cell line.

8 on changes with limited overlap between each cell line.

9 ples and an engineered CRISPR/Cas9 ABCA12 KO cell line.

10 ne toxicity on a human intestinal epithelial cell line.

11 reas leaves were effective only against HeLa cell line.

12 argeted sequencing datasets with the NA12878 cell line.

13 enza virus A/Puerto Rico/8/34 (H1N1) in MDCK cell line.

14 ted on primary human NK cells and the NK92MI cell line.

15 days versus 210 days, for the breast cancer cell line.

16 egulator of YAP signaling in a preosteoblast cell line.

17 h in previous studies that employed the same cell line.

18 deficient Oli-neu oligodendroglial precursor cell line.

19 sing the thermosensitive CCT-mutant CHO-MT58 cell line.

20 mportantly no cytotoxicity in four mammalian cell lines.

21 d can inhibit proliferation of Myc-dependent cell lines.

22 nt tumor-suppressing pathway in multiple HCC cell lines.

23 of their activity against five human cancer cell lines.

24 -1 was restricted only by IFN-alpha in these cell lines.

25 nds presented mild toxicity toward mammalian cell lines.

26 edges labeled with chromatin states in human cell lines.

27 ons of 52 HapMap Yoruba human lymphoblastoid cell lines.

28 (6)A peaks in 60 Yoruba (YRI) lymphoblastoid cell lines.

29 nfection are different in mouse versus human cell lines.

30 es from a series of patient-derived melanoma cell lines.

31 ries of patient-derived BRAF mutant melanoma cell lines.

32 n the cell cycle of PANC-1 and AsPC-1 cancer cell lines.

33 ll viability of 786-O and Caki-1 human ccRCC cell lines.

34 ability to replicate in virus-resistant PDAC cell lines.

35 he identity of cell lines including isogenic cell lines.

36 l development in humans, model organisms and cell lines.

37 using double-transgenic mice and myoblastic cell lines.

38 cultures and in mouse and human trophoblast cell lines.

39 the extracted protein mixtures of the cancer cell lines.

40 plex, reduced viral replication in two human cell lines.

41 MARV during infection of both bat and human cell lines.

42 ng of genomic compartments observed in human cell lines.

43 ed from 95 HLA-A, -B, -C and -G mono-allelic cell lines.

44 response was inconsistent between three ALT+ cell lines.

45 vitro cytotoxicity against a panel of cancer cell lines.

46 chemia resistance in NRF2-overexpressing HCC cell lines.

47 as not observed in radioresistant male NSCLC cell lines.

48 tudies of differentially methylated isogenic cell lines.

49 d experimentally in 11 patient-derived tumor cell lines.

50 f MVA enhances replication in numerous human cell lines.

51 n isogenic TP53-WT and TP53-null (TP53(-/-)) cell lines.

52 n several Ewing sarcoma and multiple myeloma cell lines.

53 nalysis in a sensitive and resistant pair of cell lines.

54 sition inside of a human monocyte-like THP-1 cells line.

55 ncer), and one kind of EpCAM negative cancer cell line (293T kidney cancer).

56 More than half of the cell lines (60%) were considered to be sensitive.

57 In human tumor cell lines, ABCC4 knockdown and inhibition reduced full-

58 ibroblast NHDF cell lines, and on neoplastic cell lines: acute monocytic leukemia THP-1 and lung aden

59 e transcriptomic profiles derived from human cell lines after chemical compound treatment to train ou

60 Comparison of cell line and human patient data suggests that the relat

61 inhibit tumor growth in a mouse glioblastoma cell line and in a whole-animal study.

62 was initially identified in a megakaryocytic cell line and is an emerging therapeutic target in cance

63 FH mutants to WT FH levels on a human HAP-1 cell line and on sheep erythrocytes.

64 Using the mouse insulinoma MIN6 cell line and pancreatic islets, we investigated the eff

65 ls (A cells) from the human HUDEP2 erythroid cell line and primary human erythroid cultures.

66 d from formalin-fixed tumors, a POLE mutated cell line and standard DNA by WES and five different pan

67 In human breast cancer cell lines and 4T1 mouse mammary tumor cells, PD-L1 expr

68 Cell lines and acini cultures were incubated with IL22 a

69 Herein, we combined reporter cell lines and activity-based protein profiling (ABPP) c

70 therapy in a subset of HER2(+) breast cancer cell lines and allow cancer cells to proliferate in the

71 ment increased PD-L1 expression in the tumor cell lines and caused up to a 12-fold increase in tracer

72 transcriptomics) are applied to manipulated cell lines and cohorts of clinically characterized indiv

73 In an analysis of IEC cell lines and colonoids derived from CRT-knockout mice,

74 impacts circadian rhythms in bipolar patient cell lines and crucially if lithium's effect on the cloc

75 SVC112 reduced sphere formation by cell lines and CSCs.

76 velopment and function, including EndoC-beta cell lines and human induced pluripotent stem cell-deriv

77 lectively inhibiting mouse and human cGAS in cell lines and human primary cells.

78 ted these pathways in various cultured human cell lines and in mouse embryonic fibroblasts.

79 its promoter region in luminal breast cancer cell lines and indirectly through a distal estrogen-resp

80 d p24) in T-cells and macrophages using both cell lines and infected primary cells.

81 mising activity against several human cancer cell lines and inhibits tumor cell migration, contains a

82 In studies of pancreatic cancer cell lines and mice, we found that ZIP4 increases expres

83 t a measure of Ras dependency in both cancer cell lines and patient samples.

84 (WT)- and V5-FOXL2(C134W)-inducible isogenic cell lines and performed chromatin immunoprecipitation s

85 th different active site geometries in three cell lines and peripheral blood mononuclear cells.

86 sis in several mutant and FLT3-resistant AML cell lines and primary blasts from AML patients, while s

87 ctivity and inhibited apoptosis in human AML cell lines and primary cells.

88 y donors killed CBFB-MYH11+ HLA-B*40:01+ AML cell lines and primary human AML samples in vitro.

89 We use mammalian cell lines and proband-derived fibroblasts to further co

90 pound 1 was cytotoxic for both breast cancer cell lines and the majority of cells died by treatment-i

91 Methods are evaluated using data from both cell lines and tissues and from both plate- and droplet-

92 cal boundary marks and more conserved across cell lines and tissues.

93 induced HEXIM1 expression in prostate cancer cell lines and triple negative breast cancers.

94 y found PI3K pathway activation in human MCC cell lines and tumors and demonstrated complete clinical

95 In cancer cell lines and xenograft models, mRNA and protein expres

96 nd validated with DNA from two breast cancer cell-lines and two patient tumour tissue samples through

97 receptors in an engineered U2OS osteosarcoma cell line, and increase cellular phospho-STAT3 levels in

98 hanced AKT sensitivity in a subset of cancer cell lines, and a far richer array of PARP inhibitor com

99 years the emergence of authentic human beta-cell lines, and advances in genome-editing technologies

100 ompounds were further tested on six lymphoma cell lines, and eight showed potent growth inhibitory ef

101 h in vitro, with low-passage patient-derived cell lines, and in vivo, using orthotopic models of glio

102 ic acid to induce FXR activity in organoids, cell lines, and mice.

103 blast Balb/3T3, human dermal fibroblast NHDF cell lines, and on neoplastic cell lines: acute monocyti

104 hich we addressed using cancer patient data, cell lines, and orthotopic mouse models.

105 e activated in the Rho(High) BRAFi-resistant cell lines, and resistant cells are more sensitive to in

106 or CI-M6PR-mediated cargo internalization in cell lines, and uncover the exocyst complex as a previou

107 er describe how OOPS can be applied in human cell lines, Arabidopsis thaliana, Schizosaccharomyces po

108 The cell lines are ideal for further examination of the role

109 However, some PDAC cell lines are resistant to VSV.

110 Cultured cell lines are widely used for research in the physiolog

111 Monolayers of cancer-derived cell lines are widely used in the modelling of the gastr

112 ming that its expression is elevated in this cell line as well.

113 ation of deep learning for the automation of cell line authentication into a readily available easy-t

114 endometrial cancer cells and patient-derived cell lines because we hypothesized that variants would l

115 Human cholangiocytes, epithelial cells lining bile ducts, were cultured as polarized epit

116 pindle abnormalities not only in the SH-SY5Y cell line, but also cell lines derived from colon and br

117 ttern on four melanoma and two neuroblastoma cell lines by high performance liquid chromatography (HP

118 trogen-responsive region in ERalpha-positive cell lines by upregulation of ERalpha.

119 e primed in vitro with a papillary TC or ATC cell line conditioned medium (CM) or with a normal thyro

120 We propose that the C8D1A cell line could be used to decipher prion strain biology

121 Our studies on several meningioma cell lines cultured in hypoxic conditions validated the

122 Therefore, understanding to what extent cell lines cultured under artificial conditions reflect

123 rm critical cancer driver genes by analysing cell-line datasets.

124 In vivo, SHH interference in colon cancer cell lines decreased primary tumor growth and metastasis

125 Radiosensitive male NSCLC cell lines demonstrated a dose-dependent induction of li

126 rangements of the respiratory chain in human cell lines depleted of the catalytic complex IV subunit

127 BE1(102C>A) mutation in a primary fibroblast cell line derived from a high genetic merit heterozygous

128 ulfotransferase 1 in two of three fibroblast cell lines derived from affected individuals.

129 not only in the SH-SY5Y cell line, but also cell lines derived from colon and breast tissues.

130 n response to high glucose in lymphoblastoid cell lines derived from matched individuals with type 1

131 By using an isogenic panel of cell lines derived from MDA-MB-231 breast cancer cells t

132 r abnormalities, and melanoma progression in cell lines derived from various stages of melanoma progr

133 Glial cell line-derived neurotrophic factor (GDNF) binds the G

134 These are then combined with the cell line-derived transcriptomic datasets through elasti

135 Glial cell-line-derived neurotrophic factor levels were signif

136 A large number of aggressive cancer cell lines display elevated levels of activated Rac1, a

137 These patient cell lines displayed DNA damage repair defects that were

138 delineation of the CD22 interactome in the B cell line DT40.

139 riments performed on the MCF-7 breast cancer cell line (ER-positive and HER(2)-negative) demonstrated

140 ction of murine HCC models and corresponding cell lines establishes the role of driver genes in diver

141 vator 1 to hPXR; 6) activates hPXR in HepaRG cell lines even when hCAR is knocked out; and 7) activat

142 These cell lines exhibit a substantial reduction in total HCP

143 Patient-derived cell lines exhibit sensitivity to topoisomerase and PARP

144 ment of BRJ inhibits proliferation of Caco-2 cell lines, exhibiting non-cytotoxic effect for HIMEC no

145 recombinant human corneal limbal epithelial cell line expressing a LC3-GFP fusion protein was challe

146 ences on FcgammaR-IgG interactions, reporter cell lines expressing common allotypes of human and rhes

147 We used CRISPR-Cas9 to engineer human cell lines expressing POLE tumor variants, with and with

148 s, CHyMErA identifies exons underlying human cell line fitness.

149 Here, using human cell lines, fluorescence microscopy, and pulldown and im

150 (125)I-KX1 was assessed in 19 neuroblastoma cell lines, followed by in-depth pharmacologic analysis

151 hibitors, we screened a panel of 53 melanoma cell lines for drug sensitivity.

152 ptase in real time, we evaluated 60 melanoma cell lines for TERT promoter mutational status, copy num

153 ed single-cell RNA-seq to profile 198 cancer cell lines from 22 cancer types.

154 Spike-protein-reactive T cell lines generated from SARS-CoV-2-naive healthy donor

155 actor receptor 1 (FGFR1) expression in NSCLC cell lines H1975, HCC827, and YLR086, and knockdown of F

156 R/Cas9 knockout screening across hundreds of cell lines has identified genes whose disruption leads t

157 rformed in cancer patients and tumor-derived cell lines have identified a high frequency of alteratio

158 formed Protect-seq on the human colon cancer cell line HCT-116 and observed overlap with previously c

159 ids formed from two established human cancer cell lines (HCT116 and CAL27) to single and combination

160 encing (RNA-seq) data from colorectal cancer cell lines (HCT116, RKO, and SW48) that were untreated o

161 -1) to infect the human DRG-derived neuronal cell line HD10.6 in order to study the establishment and

162 As control cell lines HEK 293 from embryonic kidney and RC 124 from

163 ype 3 p6 (Kernow C-1) and the human hepatoma cell lines HepG2 and HepG2/C3A with different media cond

164 sh isogenic human ESC-derived microglia-like cell lines (hMGLs) harboring AD variants in CD33, INPP5D

165 osidase activities and ii) colorectal cancer cell line (HT29) growth was also studied.

166 Proteomic comparison of ILC and IDC cell lines identified induction of PI3K/Akt and p90-RSK

167 res of a human bladder epithelial progenitor cell line in a dose-dependent manner, achieving far high

168 nhibited the phosphorylation of c-Jun in SCC cell line in a dose-dependent manner.

169 In this study, we cultured ovarian cancer cell lines in adherent and nonadherent conditions in vit

170 ing the metastatic potential of human cancer cell lines in mouse xenografts at scale.

171 Metastasis-derived cell lines in vitro and metastases analyzed ex vivo from

172 Tested against a panel of GBM cell lines in vitro, paclitaxel was found to be effectiv

173 sociated protein 9 was used to generate HeLa cell lines in which ENT expression was limited to ENT1 o

174 based on functional proliferation studies in cell lines (in vitro and in vivo) with genetic manipulat

175 n cancer cells, including six validated HGSC cell lines, in highly immunocompromised NSG mice by vary

176 nables routine monitoring of the identity of cell lines including isogenic cell lines.

177 a marked sensitivity of hematological cancer cell lines, including B-cell lymphomas, to the potent pa

178 was characterized using four prostate cancer cell lines, including PC-3, VCaP, DU-145, and LNCaP, obt

179 n-ceRNA events from thousands of samples and cell lines, including: (i) more than 2000 experimentally

180 transgenic overexpression of TMPRSS13 in CRC cell lines increased tolerance to apoptosis-inducing age

181 ry fate was confirmed in a human hepatoblast cell line, indicating the relevance of this pathway for

182 orescent labeled exosomes derived from three cell lines injected systemically into C57BL/6 mice revea

183 ma dataset derived from the sublineages of a cell line involving 20 clones with 2367 mutations, which

184 uencing (RNA-seq) analysis of IRAK4 knockout cell lines (IRAK4 KOs) showed that the IRAK pathway indu

185 capularis cell line ISE18 and Ixodes ricinus cell lines IRE/CTVM19 and IRE/CTVM20 had modal chromosom

186 ample, the highly passaged Ixodes scapularis cell line ISE18 and Ixodes ricinus cell lines IRE/CTVM19

187 L patients as well as the blast crisis phase cell lines, Kcl-22 and K562, formed few or no TNTs.

188 A KID syndrome cell line (KID-KC) was established from primary patient

189 ther examined a non-neoplastic human primary cell line (lung lymphatic endothelial cells) as a typica

190 Our results indicate that cell lines manifesting high glycogen storage level showe

191 to test three kinds of EpCAM positive cancer cell lines (MCF-7 breast cancer, SW480 colon cancer, and

192 ntiated the nontumorigenic breast epithelial cell line (MCF10A) from its cancerous PTEN mutants (MCF1

193 on of SASH1 levels in a panel of lung cancer cell lines mediated changes in cellular proliferation an

194 the BCR in the endoplasmic reticulum of MCD cell line models and promotes the turnover of immature g

195 tide synthesis, while decreasing invasion in cell line models and suppressing growth in tumor xenogra

196 pattern upon drug treatments in human cancer cell line models derived from HCT116.

197 tivity of SP was investigated in primary and cell line models of HIV-1 latency and reactivation.

198 hment of patient derived xenograft (PDX) and cell line models that reflect the genomic and biological

199 tibody-mediated inhibition of IL2RA in human cell lines, mouse models, and primary patient samples, w

200 ress sensor uniquely expressed in epithelial cells lining mucosal surfaces.

201 by a second in vivo model using the leukemia cell line NALM6.

202 oach by comparing CD16a isolated from two NK cell lines, NK92 and YTS, with CD16a expressed by HEK293

203 d by MDM2, and in therapy-resistant melanoma cell lines, nuclear accumulation of MDM2 caused downregu

204 orm DNA copy number profiling on mixtures of cell lines, nuclei from frozen prostate tumors, and biop

205 f the MAP kinases ERK1/2 in FGF-2-stimulated cell lines of affected individuals that could be restore

206 These cell lines offer a model for CRC metastatic progression;

207 Also, the Ornithodoros moubata cell line OME/CTVM22 had the modal chromosome number 33

208 b-based tool for integrative analysis of CHO cell line omics data that provides an interactive visual

209 te them from matched GE profiles of the same cell line or tissue measured on different platforms.

210 s that cannot be captured by using surrogate cell lines or animal models.

211 primary intestinal intraepithelial CD8(+) T-cell lines, or CD8(+) T cells directly isolated from int

212 reatest variability in expression across the cell line panel.

213 o reveal cellular mechanisms associated with cell line phenotypes and guide process optimization, com

214 DynaFit revealed that cell fitness in cancer cell lines, primary cancer cells, and fibroblasts under

215 modulators of the FAO pathway in established cell lines, primary cells and mice.

216 ses, suggesting that analysis of established cell lines probably underestimates mitotic dysfunction i

217 21-plex quantification of labeled K562 human cell line protein digests via single-shot nanoLC-MS/MS a

218 DU 145, HeLa, HCT 116, and MCF7 human cancer cell lines provide insights into the impact of structura

219 or MEF2A in 32 distinct human lymphoblastoid cell lines, providing insights into the main factors dri

220 The murine macrophage cell line RAW 264.7 was three-dimensionally cultured in

221 This was duplicated in a cell line (RBL-MRGPRX2).

222 ally relevant, as deletion of RUNX1 in ccRCC cell lines reduced tumor cell growth and viability in vi

223 samples revealed activity against all tested cell lines regardless of fertilization rate, whereas lea

224 d by EP2 receptor activation in a microglial cell line, reinforcing the use of EP2 antagonists as ant

225 dy or CRISPR knockout of IL37 in lung cancer cell lines repolarized TAMs, resulting in recovered cyto

226 totoxicity were observed in eyesalve-treated cell lines representative of skin and immune cells.

227 Each cell line represents a different characteristic level of

228 roteomics analysis of the O. mossambicus OmB cell line revealed that glutamine synthetase is transcri

229 nd ATAC-sequencing analyses of tumor-derived cell lines revealed downregulation of TGFbeta signaling

230 omparison to analogous data from transformed cell lines revealed respiratory-specific processes hijac

231 th susceptibility to this drug across glioma cell lines, revealing ribosomal protein subunit RPS11, 1

232 state cancer patients, on non-tumor prostate cell lines (RWPE-1 and PNT-2).

233 nvestigate this, we performed robotic cancer cell line screens and discovered a marked sensitivity of

234 Furthermore, 40% of AML cell lines showed a combined loss of the expression of m

235 ved during cisplatin treatment, indicating a cell line-specific and platin-dependent adaption mechani

236 urvival after external-beam radiotherapy was cell-line-specific, indicating varying levels of intrins

237 micromolar range among various tested cancer cell lines such as A2780 (0.23 muM), PC3 (0.48 muM), and

238 polymerization in ARMC9 and TOGARAM1 patient cell lines suggest a role for this new JBTS-associated p

239 e from assays performed on purified melanoma cell lines, suggest that the TERT promoter harbors a mor

240 Additional results in multiple cell lines support that endocytosis is not a requirement

241 of primary hepatocytes or hepatocyte-derived cell lines supports the existence of these interactions.

242 Knockdown of these factors in cuSCC cell lines suppressed tumor cell proliferation and induc

243 be partially recapitulated in an orthogonal cell line system by the introduction of H3.3-G34W.

244 ly, 45 inhibited proliferation of two cancer cell lines that are resistant to cancer drugs and dimini

245 essing the translation efficiency of KRAS in cell lines that differ in their tRNA expression profile.

246 ously reported the creation of viable cancer cell lines that lacked detectable ORC1 or ORC2 protein w

247 a panel of genetically diverse mouse cancer cell lines that were cultured in the presence of CTLs.

248 high-throughput screening to patient-derived cell-lines that have a close connection to the disease b

249 gen Chlamydia trachomatis targets epithelial cells lining the genital mucosa.

250 membrane vesicles shed into the urine by the cells lining the nephron.

251 In mammalian cell lines, the endosomal sorting complex required for t

252 onsistent between patient tumors and derived cell lines; the expression of most markers in cell lines

253 ls including our dual fluorescence CRISPRi/a cell lines, this system can facilitate functional dissec

254 tenuation of transduction in human and mouse cell lines through type I and type III IFNs.

255 gical data means that even data with desired cell lines, tissue types, or molecular targets may not b

256 ibility, we tested the utility of the HepaRG cell line to study ddC-induced toxicity in isogenic prol

257 hermore, it highlights the potential of fish cell lines to be utilized in integrated testing strategi

258 On average, the sensitivity of human cancer cell lines to DNMDP is correlated with PDE3A expression

259 g the differential susceptibility of the two cell lines to HCoV-OC43 infection, we found that ArfGAP

260 ages the genetic diversity of multiple human cell lines to highlight viral determinants that could co

261 gies, AR reconstructed fCNAs in seven cancer cell lines to reveal the complex architecture of ecDNA,

262 orm, we successfully engineer INS-1E, a beta-cell line, to repurpose the insulin secretion machinery,

263 interference in colon, pancreatic, and lung cell lines triggered cell death through PTCH proapoptoti

264 vely studied using in vivo murine models and cell lines, typically challenged with Salmonella enteric

265 40 (SV40)-transformed human fibroblast model cell line used in this study.

266 in human and mouse skeletal muscle myoblast cell lines using a single-guide RNA (sgRNA).

267 tocol allows generation of homozygous mutant cell lines using an insertion cassette which autocatalyt

268 cancer tissues and immortalized lung cancer cell lines via indirect immunofluorescence and immunoblo

269 The importance of this gene in the A2780TR cell line was assessed, confirming that its expression i

270 ell lines; the expression of most markers in cell lines was concordant with the respective parental t

271 se xenograft models and four human and mouse cell lines we examined in vitro cisplatin/JH-RE-06 treat

272 l cells and an established human endothelial cell line, we investigated the role of AMP-activated pro

273 sm, devoid of active processing, of the same cell line were used as references.

274 Pancreatic cancer cell lines were analyzed by gene-expression microarray,

275 both patient tumors and derived low-passage cell lines were characterized by immunohistochemistry (2

276 minimal notice, experiments were terminated, cell lines were frozen, mouse colonies were culled, and

277 Murine HCC cell lines were generated from each tumor model, charact

278 tent stem cells (iPSC)-derived neuronal stem cell lines were generated from individuals with MDD.

279 Trop-2 positive cell lines were highly sensitive to sacituzumab goviteca

280 present study, two p53-mutant neuroblastoma cell lines were used as in vitro models.

281 mal pancreatic tissues, PDA tissue array and cell lines were used to determine the levels of MPC-1 an

282 ximab-resistant Raji2R and the parental Raji cell lines were used.

283 ormation in a normal human breast epithelial cell line when ERalpha was introduced.

284 aging screens against a panel of 15 reporter cell lines, which expressed a diverse set of fluorescent

285 ressed in SW480 and HCT116 colorectal cancer cell lines, which were analyzed by immunoblotting and pr

286 A cell line with a strong Trop-2 expression (CVX-8) was us

287 oliferation after incubation of the RPMI8226 cell line with an increasing activity (0.185-3.7 kBq/mL)

288 othesis by infecting an oviductal epithelial cell line with C muridarum, followed by immunoaffinity i

289 By using an U2OS osteosarcoma cell line with high metastatic potential, proven by a xe

290 Since cybrid cell lines with 73% m.3243A > G heteroplasmy (DW7) displ

291 errin receptor 1 (TfR1) in established human cell lines with a designer disulfide FRET probe.

292 We apply the tfLDA to two cell lines with a rich collection of TFs and identify co

293 Patient-derived xenografts and cell lines with C-terminal truncations showed increased

294 articularly because a large number of cancer cell lines with characteristic mesenchymal features show

295 The predictions were confirmed in studies of cell lines with different expression levels of signaling

296 we not only predict drug responses in cancer cell lines with high accuracy but also identify features

297 Transfection of these cell lines with ITCH siRNA could effectively silence the

298 nd HER2 was conducted in HER2+ breast cancer cell lines with or without PIK3CA mutations, which lead

299 ein synthesis and RRM2 levels was rescued in cell lines with the CRISPR/Cas9-mediated knockout of 4E-

300 itiation across several human lymphoblastoid cell lines (Yoruba population) and detect ~75,000 eRNA t