ライフサイエンスコーパス: cell polarity

1 critical in vivo characteristics, including cell polarity.

2 ll size control, modes of cell division, and cell polarity.

3 velopment and across the metazoa to regulate cell polarity.

4 ric intracellular complexes that couple cell-cell polarity.

5 he apical surface, thereby generating arcade cell polarity.

6 mechanisms involved in regulating bacterial cell polarity.

7 in long-term HSC frequency and loss of stem cell polarity.

8 sms depends on the spatiotemporal control of cell polarity.

9 polarized coordinately and display a planar cell polarity.

10 ortant role in the maintenance of epithelial cell polarity.

11 NMIIB-rich stress fibers, thus strengthening cell polarity.

12 t play important roles in different forms of cell polarity.

13 icated to be important for cell division and cell polarity.

14 y distributed ZO-1 mRNA leads to the loss of cell polarity.

15 anied by reduced filamentation or defects in cell polarity.

16 t cell types and regulate various aspects of cell polarity.

17 his cavitation process along with changes in cell polarity.

18 egional polarity is not controlled by tissue cell polarity.

19 , affect microtubule dynamics and interphase cell polarity.

20 a novel role of PHLPP in regulating aPKC and cell polarity.

21 stochastic model of spontaneous emergence of cell polarity.

22 s directed cell migration and causes loss of cell polarity.

23 n and subsequent collagen remodeling but not cell polarity.

24 rns between neighboring cells, termed tissue cell polarity.

25 or the biogenesis of molecular asymmetry and cell polarity.

26 ase PAR1 are essential proteins that control cell polarity.

27 d an important model system for the study of cell polarity.

28 gulated membrane traffic to cilia and planar cell polarity.

29 or-based cargo transport, and maintenance of cell polarity.

30 tion, differentiation, downgrowth and planar cell polarity.

31 cial step in the establishment of epithelial cell polarity.

32 ator of eukaryotic cellular organization and cell polarity [1].

33 roughout the subpallium, consistent with the cell polarity abnormalities we observed in vitro.

34 rumental in identifying common principles of cell polarity across diverse systems.

35 ent, decreased HSC frequency, increased stem cell polarity and a restored balance of lymphoid and mye

36 an epithelial tight junctions and preserving cell polarity and barrier function in the face of energe

37 Both cell polarity and c-Jun N-terminal kinase (JNK) activity

38 yama et al. (2019) describe a model in which cell polarity and cell shape compete to determine the or

39 e physical and functional connection between cell polarity and cell-cell adhesion machineries in mamm

40 Additional Kin1 substrates for cell polarity and cytokinesis (Tea4, Mod5, Cdc15, and Cy

41 ect a broader role for regulation of PP2A in cell polarity and cytokinesis because sds23Delta phenoty

42 Kin1 regulates cell polarity and cytokinesis through unknown mechanisms

43 chanistic connection with Pom1 signaling for cell polarity and cytokinesis.

44 t5a functions as a spatial cue to coordinate cell polarity and cytoskeletal oscillation.

45 stream regulator of chemoattractant-mediated cell polarity and cytoskeletal reorganization functionin

46 S aureus altered cell polarity and decreased the percentage of cells with

47 -binding ASPP2 peptide, prevents the loss of cell polarity and decreases the survival of H. pylori in

48 es+RG secrete a factor that promotes loss of cell polarity and delamination.

49 complex proteins, defects in neuroprogenitor cell polarity and differentiation, abnormal ciliogenesis

50 Thus, CDC42 loss suppresses AML cell polarity and division asymmetry, and CDC42 constitu

51 Maintenance of epithelial cell polarity and epithelial barrier relies on the spati

52 ve 1 (Par1) proteins have been implicated in cell polarity and epithelial morphogenesis; however, the

53 ventricular cardiomyocytes due to disrupted cell polarity and extrusion from the heart tube.

54 tribute to multiprotein complexes that drive cell polarity and fate in invertebrates.

55 importance of KISC for the establishment of cell polarity and for plant development.

56 lular destinations and is thus essential for cell polarity and function.

57 ssential for the establishment of epithelial cell polarity and functional maturation of alveolar cell

58 sional model of a human epiblast whose size, cell polarity and gene expression are similar to a day 1

59 transport and signaling to coordinate tissue cell polarity and induce vein formation.

60 r transport of auxin would coordinate tissue cell polarity and induce vein formation.

61 ompromised LKB1 function affects lung cancer cell polarity and invasion.

62 larly focusing on how it may act to regulate cell polarity and its potential to regulate cell tumorig

63 e the established connection between loss-of-cell polarity and JNK activation, much less is known abo

64 The Rho-family GTPase Cdc42 regulates cell polarity and localizes to the cell division site.

65 the establishment of apical-basal epithelial cell polarity and lumen formation, as well as mammary gl

66 dicate that cadherin endocytosis coordinates cell polarity and migration cues through actin remodelin

67 in eukaryotic cell physiology, ranging from cell polarity and migration to cytokinesis.

68 Integrin beta3 regulates cell polarity and migration when localized appropriately

69 ing, proliferation, cell fate specification, cell polarity and migration.

70 extracellular matrix plays a crucial role in cell polarity and migration.

71 ss response and adaptation, cell signalling, cell polarity and morphology, vacuole trafficking, trans

72 LD2 and mTORC2) feedback loops in organizing cell polarity and motility-the indirect loop is better s

73 , which is required for the establishment of cell polarity and normal subcellular organization.

74 ngate, and endoderm organization, ectodermal cell polarity and patterning along the oral-aboral axis

75 d considerable downregulation on a number of cell polarity and planar cell polarity (PCP) proteins, a

76 Ras homology (Rho) GTPases regulate cell polarity and signal transduction pathways to contro

77 s as a molecular compass that orients motile cell polarity and spatially directs tissue movement.

78 a known microtubule-binding protein, control cell polarity and spindle orientation of NBs.

79 rgence seems to involve genes with a role in cell polarity and that likely function in the maintenanc

80 ugh much is known about how Cdc42p regulates cell polarity and the mating pathway, how Cdc42p regulat

81 ancient role for brachyury in morphogenesis, cell polarity and the patterning of both ectodermal and

82 lar functions including the establishment of cell polarity and the remodeling of the actin cytoskelet

83 here it helps to establish proper epithelial cell polarity and tissue homeostasis during lactation.

84 hat these defects might arise due to altered cell polarity and/or changes in cell proliferation/diffe

85 cell machineries, such as cell-cell contact, cell polarity, and actin cytoskeleton, as well as a wide

86 use it apparently disrupts PKCzeta activity, cell polarity, and bone resorption and increases secreti

87 istic links between intercellular signaling, cell polarity, and cellular organization remain unclear.

88 cluding enhanced F-actin assembly, disturbed cell polarity, and increased cell motility.

89 vement is critical for developmental events, cell polarity, and migration and is usually mediated by

90 tivity of PKCzeta, a PKC isoform controlling cell polarity, and that addition of a PKCzeta pseudosubs

91 In yeast, the Rho GTPase Cdc42p regulates cell polarity, and through the p21-activated kinase Ste2

92 While cell polarity appears normal, and chromosome and furrow

93 Defects in cell polarity are associated with neurologic disorders i

94 n at cell-cell junctions and its coupling to cell polarity are pivotal for the generation of these co

95 PRICKLE2 distribution reveals the planar cell polarity axis in the underlying epithelium is organ

96 e findings suggest that maintaining the host cell-polarity barrier would reduce the detrimental conse

97 We show that tissue cell polarity, based on localization of the auxin transp

98 ts cell contractility, cell adhesion, and/or cell polarity but is independent of transcription and tr

99 rin function is dispensable for pre-follicle cell polarity but is required to maintain cellular organ

100 uronal membrane/lipid rafts (MLRs) establish cell polarity by clustering progrowth receptors and teth

101 We found that Ssp1 promotes cell polarity by phosphorylating the activation loop of

102 ling pathway that controls growth and planar cell polarity by regulating the membrane localization of

103 Par-3 regulates animal cell polarity by targeting the Par complex proteins Par-

104 ulate endocytic trafficking of at least four cell polarity, cell junction and apical extracellular ma

105 on of genes important for insulin secretion, cell polarity, cell junction, cilia, cytoskeleton, vesic

106 ar processes, including the establishment of cell polarity, cell migration, tissue integrity, and mor

107 transduction, cytoskeletal organization and cell polarity, cell proliferation and differentiation, i

108 cell growth, providing a novel mechanism of cell polarity control apart from the one involving prote

109 s depends on formation of epidermal sites of cell polarity convergence with high intracellular auxin

110 n filaments: low) as the basis for intrinsic cell polarity defects in HGPS and physiological aging an

111 deletion mutants that upregulate Pyr exhibit cell polarity defects that lead to invagination defects

112 pe of hair cells with innervation and planar cell polarity defects.

113 ng protein known primarily for its role as a cell polarity determinant, orchestrates the intracellula

114 The inhibition of protrusive activity and cell polarity disables confinement-dependent cell scatte

115 Mechanistically, we found that cell polarity disruption activates JNK signaling, which

116 troys contact inhibition potentially through cell polarity disruption, and results in increased tumor

117 Wg signaling is necessary and sufficient for cell polarity disruption-induced cell migration and mole

118 these effectors disorganizes the epithelial cell polarity, disturbs epithelial barrier integrity, pr

119 anar polarity pathway coordinates epithelial cell polarity during animal development, and loss of its

120 egulation of cell differentiation and planar cell polarity during development.

121 ontrol by GNOM in the coordination of tissue cell polarity during vein patterning, one of the most in

122 Here, to identify components involved in cell polarity establishment and maintenance in plants, w

123 formins, mediate intracellular transport for cell polarity establishment and maintenance.

124 s are implicated in focal adhesion turnover, cell polarity establishment, and migration, illustrating

125 liberate but unprecedented rearrangements of cell polarity factors during ER stress safeguard cell su

126 nserved apical complex protein essential for cell polarity, fate and survival.

127 for generation of convergence sites is that cell polarity for the auxin transporter PIN1 orients up

128 roles (promoting cell survival and altering cell polarity) for genetic alterations of CTCF in endome

129 not basolateral, recycling, implicating this cell polarity gene in assembly or maintenance of the api

130 an in vivo invasion model via knocking down cell polarity gene in Drosophila wing discs, and identif

131 fl)), a mammalian ortholog of the Drosophila cell polarity gene lgl, exhibit MCCs resembling severe p

132 based matrix, epithelial cilia or the planar cell polarity genes Vangl2 and Ptk7 In wild-type mice, c

133 The roles of Scrib and Lgl1 in apical-basal cell polarity have been studied extensively, but little

134 to energize pollen tube growth and underlie cell polarity, however, mechanistic evidence for this is

135 tic effects through interplay between tissue cell polarity, identity, and growth.

136 n in amphibians and zebrafish by controlling cell polarity in a cell contact-dependent manner.

137 This study underscores the importance of cell polarity in AAV transduction and provides a potenti

138 lates microtubule-dependent establishment of cell polarity in Arabidopsis.

139 ulator of toll-like receptor 4 responses and cell polarity in biliary epithelial cells; this mechanis

140 ics that establish columnar shape and planar cell polarity in epidermal progenitors.

141 oid reveals that vinculin knockdown disrupts cell polarity in microtracks.

142 at regulates microtubule dynamics and planar cell polarity in multi-ciliated cells.

143 We show that MLL-AF9 leukemia cells maintain cell polarity in the context of elevated Cdc42-guanosine

144 Establishment of cell polarity in the mammalian embryo is fundamental for

145 mbryo.The molecular trigger that establishes cell polarity in the mammalian embryo is unclear.

146 s, been shown to be associated with a planar cell polarity in the organisation of the actin-myosin cy

147 Mutant gonads showed a loss of cell polarity in the surface epithelial layers, large in

148 l information is an important contributor to cell polarity in uni- and multicellular systems [1-3].

149 that the gene-regulatory network determining cell polarity includes an undiscovered polarity effector

150 ut the molecular mechanism by which aberrant cell polarity induces JNK-mediated cell migration and tu

151 enesis potentially through the regulation of cell polarity integrity.

152 enetic analysis of proteins linked to planar cell polarity (Inturned, Fuzzy and Wdpcp), we identified

153 In many cells, polarity involves mutual antagonism between the P

154 Cell polarity is a fundamental feature of all multicellu

155 Although disruption of cell polarity is a prerequisite in epithelial tumor init

156 While cell polarity is an intrinsic organizer of morphogenic e

157 Metazoan cell polarity is controlled by a set of highly conserved

158 The generation of cell polarity is essential for the development of multi-

159 in Nematostella embryos, we demonstrate that cell polarity is established by the four-cell stage and

160 For motility, a leading-lagging cell polarity is established that is inverted during cel

161 However, it is unclear whether cell polarity is established through cell-intrinsic or -

162 Establishing apical-basal epithelial cell polarity is fundamental for mammary gland duct morp

163 Cell polarity is fundamental for tissue morphogenesis in

164 Cell polarity is fundamental to the development of both

165 the effect of Scrib and Lgl1 interaction on cell polarity is largely unknown.

166 Cell polarity is regulated by highly conserved cell pola

167 Tissue cell polarity is widespread in plants and can influence

168 In bilaterians and cnidarians, epithelial cell-polarity is regulated by the interactions between P

169 lants, directional signaling, and implicitly cell polarity, is proposed to participate in this coordi

170 The cell polarity kinase Par-1 is required for cells to form

171 efines a new signaling mechanism driven by a cell polarity kinase that promotes CAR assembly in the c

172 In migrating cells, CARMIL2 is important for cell polarity, lamellipodial assembly, ruffling, and mac

173 provides a novel mechanistic insight on how cell polarity loss contributes to cell invasion, but als

174 PIN auxin transporters are important cell polarity markers that play crucial roles in a pleth

175 s robust to relatively high levels of planar cell polarity misalignment and to the presence of non-ac

176 the growing pollen tube, a well-established cell polarity model system, and performed large-scale ex

177 A novel cell polarity network is uncovered comprising TKS5, FGD1

178 protein kinases that function within complex cell polarity networks are poorly understood.

179 (PAR) polarity complex and leads to loss of cell polarity of infected cells.

180 w insights into the mechanism regulating the cell polarity of migrating cells by Scrib, Lgl1, and myo

181 but little is known about their roles in the cell polarity of migrating cells.

182 that Scrib and Lgl1 are required for proper cell polarity of migrating cells.

183 sion of actomyosin with blebbistatin reduces cell polarity on a flat surface, but not on a surface wi

184 s that choreograph downstream processes like cell polarity or cell division.

185 tion alleles that were functional for either cell polarity or nuclear cycling but not both.

186 Here we show that the Dchs1-Fat4 planar cell polarity pathway controls cell orientation in the e

187 lar control via the non-canonical Wnt/planar cell polarity pathway, Shh/BMP signalling, and the trans

188 al divisions via the noncanonical WNT/planar cell polarity pathway, to modify stem cell pool expansio

189 s not by signalingviathe WNT/Ca(2+)or planar cell polarity pathways, but rather by inhibiting the can

190 We find that in the shoot, cell polarity patterns follow MP expression, which in tu

191 nalling has been proposed to regulate planar cell polarity (PCP) and activity of the Hippo effectors

192 rins are giant proteins that regulate planar cell polarity (PCP) and cell adhesion in bilaterians.

193 Planar cell polarity (PCP) and neural tube defects (NTDs) are l

194 strate that several components of the planar cell polarity (PCP) arm of non-canonical Wnt signaling i

195 Defects in planar cell polarity (PCP) can disrupt spindle positioning duri

196 The absence of planar cell polarity (PCP) core proteins Prickle1 and Prickle2

197 zy, proteins previously implicated as planar cell polarity (PCP) effectors and in developmentally reg

198 that mouse embryos defective for the planar cell polarity (PCP) gene, Vangl2, exhibit increased perp

199 l activation of atypical cadherin and planar cell polarity (PCP) genes.

200 h1) in epithelial cell patterning and planar cell polarity (PCP) in Drosophila.

201 sous (Ds) have been found to underlie planar cell polarity (PCP) in many tissues.

202 organ to exhibit a particular form of planar cell polarity (PCP) necessary for mechanotransduction.

203 n is the rotational and translational planar cell polarity (PCP) of E1 cells.

204 Planar cell polarity (PCP) organizes the orientation of cellula

205 In the mammalian cochlea, the planar cell polarity (PCP) pathway aligns hair cell orientation

206 The planar cell polarity (PCP) pathway is best known for its role i

207 We found that the planar cell polarity (PCP) pathway is required in alveolar epit

208 r3 and Vangl2, core components of the planar cell polarity (PCP) pathway, are localized at developing

209 oss of Wnt5, a putative ligand of the planar cell polarity (PCP) pathway, causes the SpM-SHF to expan

210 The Wnt planar cell polarity (PCP) pathway, through the recruitment of

211 quired for explant elongation via the planar cell polarity (PCP) pathway.

212 Planar cell polarity (PCP) plays crucial roles in developmental

213 a nonautonomous function of the core planar cell polarity (PCP) protein VANGL2.

214 hereupon cell division, transmembrane planar cell polarity (PCP) proteins are removed from the cell s

215 The core planar cell polarity (PCP) proteins coordinate the orientations

216 Planar cell polarity (PCP) proteins localize asymmetrically to

217 tion on a number of cell polarity and planar cell polarity (PCP) proteins, and studies have shown the

218 Whether planar cell polarity (PCP) proteins, which regulate cytoskeleto

219 Planar cell polarity (PCP) refers to the collective alignment o

220 Planar cell polarity (PCP) reflects cellular orientation within

221 action of tissue-level, intercellular planar cell polarity (PCP) signaling and a hair cell-intrinsic,

222 Core planar cell polarity (PCP) signaling controls OCD and CE in oth

223 Wnt-Frizzled/planar cell polarity (PCP) signaling establishes cell orientati

224 ness therapies.SIGNIFICANCE STATEMENT Planar cell polarity (PCP) signaling has emerged as a complemen

225 This regulatory link between Shh and planar cell polarity (PCP) signaling may also occur in other de

226 Much of the Hippo and planar cell polarity (PCP) signaling mediated by the Drosophila

227 Here we provide evidence that planar cell polarity (PCP) signaling orchestrates directed epit

228 Planar cell polarity (PCP) signaling orients developmental even

229 Subcellular asymmetry directed by the planar cell polarity (PCP) signaling pathway orients numerous m

230 l for patterning of the AP axis while planar cell polarity (PCP) signaling polarizes cells with respe

231 E) defects, arising from impaired Wnt/planar cell polarity (PCP) signaling.

232 n-canonical pathways, WNT5A activates planar cell polarity (PCP) signaling.

233 Planar cell polarity (PCP) signalling is a well-conserved devel

234 SP was dependent on components of the planar cell polarity (PCP) system in the disc, and neither Dpp-

235 iginally identified as an effector of planar cell polarity (PCP) under control of Rho kinase, is esse

236 Planar cell polarity (PCP), the long-range in-plane polarizatio

237 exists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epitheli

238 osette dynamics are regulated by both planar cell polarity (PCP)-dependent and -independent pathways.

239 cells become packed as they engage in planar cell polarity (PCP)-dependent movement.

240 served in ommatidial rotation (OR), a planar cell polarity (PCP)-mediated cell motility process.

241 lly in flies to coordinate epithelial planar cell polarity (PCP).

242 We propose that, in addition to cell polarity, PCP components control basal body organiz

243 tyrosine kinase receptor involved in planar cell polarity, plays a role in epithelial Wnt signaling;

244 m1 mouse mutants originate from defective LE cell polarity, proliferation and cell adhesion.

245 e gastrulation accompanied by a VANGL planar cell polarity protein 2 (Vangl2)-regulated increase in f

246 issues, we analyzed the behavior of a tissue cell polarity protein BASL (BREAKING OF ASYMMETRY IN THE

247 ll polarity is regulated by highly conserved cell polarity protein complexes such as the Par3-aPKC-Pa

248 nctional interaction of VE-cadherin with the cell polarity protein Pals1.

249 Here, we show that the conserved cell polarity protein Par3 is essential for planar polar

250 0c further targets and suppresses PKCzeta, a cell polarity protein that has a pivotal role in directi

251 hese data reveal a direct connection between cell polarity proteins and Hippo, which is essential for

252 While it is well known that cell polarity proteins govern the formation of AJCs, the

253 The VANGL family of planar cell polarity proteins is implicated in breast cancer ho

254 These cell polarity proteins often exhibit coordinated pattern

255 ediated through its interaction with the two cell polarity proteins Pals1 and Par3.

256 epithelial architecture with proliferation, cell polarity proteins undergo extensive remodeling duri

257 d cancer; however, the mechanisms connecting cell polarity proteins with intracellular signaling path

258 h downregulation of the tumor suppressor and cell polarity regulator, PARD3, reduced the CFD, in agre

259 hering complex exocyst is one of the crucial cell polarity regulators.

260 isms by which such signals induce changes in cell polarity remain unknown.

261 In planar tissues like the Drosophila wing, cell polarity reorients during growth as cells divide an

262 Development of cell polarity requires apical trafficking of podocalyxin

263 gly, analysis of the spatial organization of cell polarity revealed that hepatocytes are not randomly

264 s of actin organization in determining plant cell polarity, shape and plant growth.

265 erturbation analyses demonstrate that planar cell polarity signaling enables cells to pivot in the di

266 Fat2/Lar signaling is similar to planar cell polarity signaling in terms of sub-cellular protein

267 Here we studied how cell polarity signaling orchestrates epidermal self-rene

268 r understand how Scribble PDZ domains direct cell polarity signaling, we investigated here their inte

269 Frizzled3 and Vangl2 is essential for planar cell polarity signaling.

270 Wnt/PCP (planar cell polarity) signaling, one of the noncanonical Wnt si

271 biliary epithelial cells express Wnt-Planar Cell Polarity signalling components following bile duct

272 lial migration, angiogenesis, cell adhesion, cell polarity, spermatogenesis, and metastasis.

273 cation, and acts in parallel with the planar-cell-polarity system to determine the orientation of hai

274 mutants, and the PCM-dependent induction of cell polarity that defines the anterior-posterior body a

275 e is a highly conserved protein regulator of cell polarity that has been demonstrated to function as

276 asma membrane in a gradient corresponding to cell polarity that is altered upon Rgd3 overexpression.

277 amily of kinases are conserved regulators of cell polarity that share a conserved C-terminal kinase-a

278 As a central regulator of cell polarity, the activity of CDC42 GTPase is tightly c

279 eractions, which are sufficient to establish cell polarity through contact guidance.

280 ng protein Whi3 regulates the cell cycle and cell polarity through forming macromolecular structures

281 ilamentous growth, which involves changes in cell polarity through mechanisms that remain obscure.

282 we formulate a coarse-grained description of cell polarity through self-regulated actin organization

283 Kif26b, together with Dvl3/Daam1, initiates cell polarity through the control of PCP signaling pathw

284 ical function as an integrator of epithelial cell polarity, tissue mechanics, and nutritional cues to

285 sm by which CagA disrupts gastric epithelial cell polarity to achieve its oncogenicity is not fully u

286 Key events ranging from cell polarity to proliferation regulation to neuronal si

287 PKC protein complex, a critical regulator of cell polarity, to the plasma membrane and release of Par

288 portant molecular link that mediates loss-of-cell polarity-triggered JNK activation and cell invasion

289 ects SoPIN1 patterns, suggesting that tissue cell polarity underpins oriented cell differentiation.

290 data indicate that this phenotype depends on cell polarity via the enrichment in AB of the mitotic ki

291 g in a disorganized cytoskeleton and reduced cell polarity, which likely accounts for the dominant ge

292 al transition (EMT) and disrupted epithelial cell polarity, which was associated with altered express

293 ns, thus linking intercellular signaling and cell polarity with the control of oriented cell division

294 PAR proteins coordinate the establishment of cell polarity with the physical process of cytokinesis d

295 lations through the continual realignment of cell polarity with the tissue axes.

296 al protein kinase C zeta, a mediator of stem cell polarity, with C5aR1 inhibition reducing proliferat

297 ling was shown to promote the maintenance of cell polarity, with exogenous C5a increasing the retenti

298 a stage, outer cells acquire an apical-basal cell polarity, with expression of atypical protein kinas

299 C5a was identified as a regulator of cell polarity, with inhibition of C5a receptors during e

300 proteins localize asymmetrically to instruct cell polarity within the tissue plane, with defects lead