ライフサイエンスコーパス: cell response

1 of the antigenic landscape of the overall T cell response.

2 t points of intervention for modifying the T cell response.

3 icantly higher EBOV-specific CD8+ and CD4+ T-cell response.

4 thy blood donors with a predominantly CD4+ T cell response.

5 ) that mediated immune escape by impairing T cell response.

6 aggregates on DCs and consequently on the T cell response.

7 ns and challenging mice at the peak of the T cell response.

8 g orientations and the ability to induce a T-cell response.

9 onds to immunosuppression of an Ag-induced T cell response.

10 ions that are normally restrained by a T(H)1 cell response.

11 te immune responses and adaptive cytotoxic T cell responses.

12 an be attributed to defective Th1 and CD8+ T cell responses.

13 nation approach to activate tumor-specific T cell responses.

14 ignaling is required for optimal adaptive NK cell responses.

15 nkara vector to induce HBV-specific B- and T-cell responses.

16 pe V2 loop and of envelope-specific CD4(+) T cell responses.

17 actively suppressing de novo alloreactive B cell responses.

18 the elicitation of antibody and cytotoxic T cell responses.

19 feration, bacterial cell physiology and host cell responses.

20 ayed kinetics and induce suboptimal CD8(+) T cell responses.

21 nducing potent cytotoxic CD4(+) and CD8(+) T cell responses.

22 ey determinant of Ag specificity in CD8(+) T cell responses.

23 n and dysregulated T follicular helper and B cell responses.

24 nsive macrophage population, and activated T cell responses.

25 sponses and low or undetectable Th2 or CD8 T-cell responses.

26 o co-evolution between the virus and human B cell responses.

27 h induction of neutralizing antibodies and T cell responses.

28 erating potent tumor antigen-specific CD8+ T cell responses.

29 human T helper type 1 (Th1) and cytotoxic T cell responses.

30 timulatory molecules that promote improved T cell responses.

31 targeting CD169(+) DCs to drive antitumor T cell responses.

32 aracterized by poor LASV-specific effector T-cell responses.

33 ation of memory B cell and long-lived plasma cell responses.

34 es in vaccine cells which activate de novo T cell responses.

35 frequency of Ebola GP-specific CD4 and CD8 T cell responses.

36 f circulating Tregs and reduced anti-donor T cell responses.

37 er of differentiation 8-positive (CD8(+) ) T-cell responses.

38 eal the mechanisms by which PD-1 regulates T cell responses.

39 t which BAFF-producing cells contribute to B cell responses.

40 robiome shifts and enhanced intestinal CD8 T cell responses.

41 abled us to closely monitor and quantitate T cell responses.

42 licit broadly protective CD4(+) and CD8(+) T cell responses.

43 is associated with enhanced HIV-1-specific T cell responses.

44 lls and the induction of protective CD8(+) T cell responses.

45 road induction of FSP-specific CD8 and CD4 T-cell responses.

46 d "classical" low-dimensional hexagonal grid cell responses.

47 cosal and systemic antibodies and systemic T-cell responses.

48 lar metabolism is essential for effective NK cells responses.

49 anscriptional control, facilitate optimal NK cells responses.

50 nter-individual differences in T helper (Th) cell responses affect susceptibility to infectious, alle

51 fected study participants in terms of CD4+ T-cell responses after anti-CD3 stimulation (P = .19) alth

52 demonstrate that contraction of lung CD8+ T cell responses after influenza infection is contemporize

53 ynamics and specificity of germinal centre B cell responses after influenza vaccination in humans.

54 We demonstrated recipient anti-CAR T-cell responses against a murine single-chain variable fr

55 -Barr virus and influenza virus can elicit T cell responses against abnormally expressed cellular ant

56 g noninfectious SIV particles and inducing T-cell responses against all nine SIV proteins.

57 d role of these PARPs in the modulation of T cell responses against AT-3-induced breast tumors.

58 ing and effector phases, provokes systemic T cell responses against dominant and subdominant neoantig

59 Effective T cell responses against infections and tumors require a s

60 unctional and polyfunctional CD4+ and CD8+ T-cell responses against influenza A/H1N1, A/H3N2, and B.

61 to clear bacteria and to regulate adaptive T-cell responses against microbes.

62 d result in complementary improvements in NK cell responses against NK-resistant cancers.

63 nospot (ELISPOT) assay to characterize the T cell responses against peptide pools derived from the sp

64 ne was safe and elicited mutation-specific T cell responses against predicted neoepitopes not detecte

65 an facilitates, effector and memory CD4(+) T-cell responses against Salmonella in mice.

66 umoral responses, it blunted type 1 CD4(+) T cell responses against the SIV envelope protein and fail

67 oxia, clonal stem cell selection, and immune cell response, all of which have been recently shown to

68 that chronic inflammation interferes with T-cell response and macrophage function and is also detrim

69 All showed a maintained SARS-CoV-2 T-cell response and poor cross-response to other coronavir

70 tion, thus impairing virus-specific CD8(+) T cell response and virus control in vivo.

71 findings indicate that poor LASV-specific T-cell responses and activation of nonspecific T cells wit

72 pitopes with the potential for stimulating T-cell responses and B-cell antibodies against LASV and al

73 ntigen valency has multifaceted effects on B cell responses and can dictate affinity thresholds and c

74 , Tregs are known to inhibit effector CD8+ T-cell responses and contribute to virus persistence.

75 jects exhibiting significantly blunted CD4 T-cell responses and diminished antibody responses.

76 the longevity of beta cell-specific CD8(+) T cell responses and document the use of this methylation-

77 us acute viral infections and identify CD8 T cell responses and downstream anorexia as driver mechani

78 of tumour cells induced systemic cytotoxic T-cell responses and immunological memory associated with

79 uced type 1 helper T-cell (Th1)-biased CD4 T-cell responses and low or undetectable Th2 or CD8 T-cell

80 mokines involved in generation of effector T cell responses and migration of inflammatory cells to th

81 We further assessed HIV-specific T-cell responses and post-ART viral loads.

82 antigen presentation, enhanced anti-tumour T cell responses and reduced tumour growth in syngeneic ho

83 thin lymph nodes, we observed augmented GC B cell responses and the promotion of T(h)1 gene expressio

84 epletion also impaired allospecific memory T cell responses and thereby enhanced donor hematopoietic

85 the effects of chronic viral infection on T-cell responses and vaccination against highly pathogenic

86 ptides were shown to activate this type of T cell response, and four out of these contain class I and

87 alivary IgA concentrations and tonsillar TFH-cell responses, and a positive correlation between tonsi

88 mic and mucosal immunoglobulin A (IgA) and T cell responses, and almost entirely prevents SARS-CoV-2

89 y receptor expression, HBV-specific CD4(+) T cell responses, and augmentation by checkpoint blockade.

90 tor programmed cell death 1 (PD1) inhibits T cell responses, and blockade of this interaction has pro

91 hanistically, alphaCD40/ICB primed durable T cell responses, and efficacy required DCs and host expre

92 14G mutant(2) SARS-CoV-2 as well as CD8(+) T cell responses, and protects against SARS-CoV-2 infectio

93 s that revealed large differences in cell-by-cell responses, and, more interestingly, between alleles

94 t age-associated defects in the cDC2 and Tfh cell response are not irreversible and can be enhanced t

95 y young adults that VZV-specific B and CD4 T cell responses are detectable in bone marrow (BM) and bl

96 Diverse B cell responses are important for generating antibody-med

97 suggesting that both cytotoxic and helper T-cell responses are important.

98 When CD8(+) T cell responses are inhibited, HSV-1 can reactivate, and

99 Untoward effector CD4+ T cell responses are kept in check by immune regulatory me

100 CD8+ T cell responses are necessary for immune control of simia

101 factors determining successful mounting of T cell responses are poorly defined.

102 Chen et al. revealed that initial CD4+ T cell responses are similar during early infection and th

103 ive and induced SARS-CoV-2-specific CD8(+) T cell responses as potentially important determinants of

104 -specific GC B and T follicular helper (Tfh) cell responses as well as LLPCs and MBCs.

105 n of MHC-II and CD86, and induced a memory T-cell response, attenuating tumor onset and growth after

106 ited cross-reactivity for both CD4 and CD8 T cell responses between flaviviruses and have implication

107 d to measure the frequency of EBV-specific T-cell responses between groups following stimulation with

108 assay to investigate a wide array of single-cell responses (beyond ROS) upon exposure to different t

109 tions substantially impaired the secondary T cell response, both locally and systemically.

110 eas Aer induced powerful respiratory tract T cell responses but a low titer of Abs.

111 nation had higher baseline MA-specific CD8 T cell responses but no evidence for improved functional r

112 hifted the translation component of Purkinje cell responses, but did not affect the tilt component.

113 ting cells (APC) instruct CD4+ helper T (Th) cell responses, but it is unclear whether different APC

114 e main targets of the Lassa virus-specific T cell responses, but, to date, only a few T cell epitopes

115 extrinsic downregulation of the antiviral NK cell response by adrenergic neuroendocrine signals.

116 at ACh can modulate population-level granule cell responses by altering the ratios of excitation and

117 Importantly, the Tfh and cDC2 cell response can be boosted in aged mice by treatment w

118 Strong, Th1-skewed T cell responses can drive protective humoral and cell-med

119 e of these fundamental factors that affect B cell responses can inform current vaccine design efforts

120 Fibrosis is driven by a misdirected cell response causing the overproduction of extracellula

121 Although studied at the level of B-cell responses, CD4 T-cell responses have not yet been e

122 tional capacity of peptide-specific CD4(+) T-cell responses characterized after vaccination, are comp

123 back loops or morphogen cascades to receiver cell response circuits.

124 ely associated with H3.3K27M-reactive CD8+ T cell responses.CONCLUSIONAdministration of the H3.3K27M-

125 Total and spike-specific T cell responses correlated with spike-specific antibody r

126 Tonsillar and systemic T-cell responses differed between influenza strains, and b

127 r inhibition of bacterial antigen-specific T cell responses does not alter the efficacy of BCG-induce

128 d Coss et al. explored virus-specific CD4+ T cell response during HCV infection.

129 interventions enhanced SIV-specific CD8(+) T cell responses during ART or viral control after ART int

130 gests that dysfunctional natural killer (NK) cell responses during hepatitis C virus (HCV) infection

131 of HLA-B*57:01 on the deterioration of CD8 T-cell responses during HIV infection in the absence of an

132 ing and induced SARS-CoV-2-specific CD8(+) T cell responses during the natural course of SARS-CoV-2 i

133 emonstrated that SYIPSAEKI-specific CD8(+) T cell responses elicited by viral-vectored CSP-expressing

134 vaccine therapies that could mount robust T cell responses, enhance tumor killing, and provide clini

135 improved understanding about how elicited B cell responses evolve following immunization.

136 Influenza-specific CD8+ T-cell responses expanded before the appearance of plasmab

137 ich HCV infection modulates donor-specific T cell responses following LT and the influence of HCV era

138 only, implying the importance of cytotoxic T-cell responses for the former and CD4(+) T-cell helper r

139 Unexpectedly, HPV-specific T cell responses from OPC patients were not constrained to

140 s well as antigen-specific CD8+ T-cell and B-cell responses from peripheral blood mononuclear cells u

141 with INO-4800 we measure antigen-specific T cell responses, functional antibodies which neutralize t

142 ur results illustrate the heterogeneity of T cell responses, furthering our understanding of inflamma

143 Foxp3-Cre Ptenfl/fl mice with augmented Tfr cell responses had markedly higher levels of peanut-spec

144 Early and robust T cell responses have been associated with survival from L

145 died at the level of B-cell responses, CD4 T-cell responses have not yet been examined.

146 HIV-1-specific CD4 and CD8 T-cell responses have remained absent at 27 months.

147 tabolic pathways that underly normal human T cell responses have taught us that there is still much t

148 4(+) Th1 responses predominate over CD8(+) T cell responses, have a more inflammatory profile, and ha

149 des crucial co-stimulatory signals for CD4 T cell responses, however the precise cellular interaction

150 ught to discover what underpins the poor Tfh cell response in ageing and whether it is possible to co

151 Here, we investigated the human B cell response in children after natural DENV infection i

152 MC-derived IL-13 inhibited the T(H)1 cell response in contact hypersensitivity to dinitrofluo

153 re that correlated with enhanced cytotoxic T-cell response in human solid tumors.

154 s required in T cells for a protective T(H)2 cell response in mice infected with the helminth Heligmo

155 racteristics of the peanut-specific CD4(+) T-cell response in peanut-allergic patients that correlate

156 epitopes induced a robust antiviral CD4(+) T cell response in the cornea that was associated with pro

157 e investigated EBOV-specific CD8+ and CD4+ T-cell responses in 37 Sierra Leonean EBOV disease survivo

158 ound three novel peptides that induced CD8 T cell responses in at least two Mamu-A1*001-positive anim

159 tially more antigen-responsive CD4 and CD8 T cell responses in blood, spleen, bronchoalveolar lavage

160 development of both anti-ZIKV antibody and T-cell responses in C57BL/6 mice.

161 lysis further suggests a role for specific T cell responses in hereditary versus idiopathic CP pathog

162 ART significantly reduced HIV-specific T-cell responses in HIV controllers but did not adversely

163 xpression and roles as checkpoints in immune cell responses in human diseases such as cancer, asthma,

164 es to modulate protective and pathological T cell responses in human diseases.

165 NKT cells at an apex to support or inhibit B cell responses in inflammation.

166 ification of dominant Lassa virus-specific T cell responses in Lassa fever survivors and vaccinated i

167 th infections are known to influence T and B cell responses in latent tuberculosis infection (LTBI).

168 uses increased the transgene-specific CD8+ T cell responses in mice.

169 We hypothesize that, based on nLV/nI cell responses in other teleosts and isthmic connectivit

170 Underlying these divergent T cell responses in pancreas and lung cancer are differenc

171 clinical models and can improve anticancer T cell responses in patients with advanced cancers.

172 re effective in restoring exhausted CD8(+) T cell responses in persistent viral infections or tumors.

173 s/isoallergens are involved in the diverse T-cell responses in ragweed allergic individuals.

174 YAP slows T cell responses in systemic viral infections and retards

175 sufficient for the induction of acute T(H)2-cell responses in the lungs that is independent of dendr

176 Despite robust T cell responses in the lungs, H5N1 (2:6)-infected mice sh

177 f specificity and dynamics of RSV-specific T-cell responses in the target organ, allowing the precise

178 ion implicates Yap as a mediator of global T-cell responses in the tumor microenvironment and as a ne

179 aches aimed at resolving detrimental myeloid cell responses in tissues, including those occurring in

180 henotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family

181 VA-NP+M1 elicits a substantial M1-specific T-cell response, including TRM cells, in nasopharynx-assoc

182 Here, we have studied the early tonsillar T-cell responses induced in children after LAIV.

183 the APC(s) involved in the priming of this T cell response is (are) poorly defined.

184 strate that the CoV-2-specific CD4+ T helper cell response is directed against all 3 proteins with co

185 ion, a highly frequent class I allele, the T cell response is dominated by an epitope spanning residu

186 Induction of memory T cell response is inefficient in colorectal cancer (CRC)

187 The control of NK cell responses is complex and only partially understood.

188 oost effector memory CD4(+) and CD8(+) T(EM) cell responses is discussed.

189 CD8 T cell responses likely play an important role in the cont

190 ponsive host gene expression, HIV-specific T cell responses, low-level HIV viremia, rca-RNA, and the

191 e important information relating to normal B cell responses, malignant B cell expansion, and generic

192 This local B cell response may contribute to the pathophysiology of C

193 ntibody responses, suboptimal induction of T-cell responses may reduce protection.

194 Notably, we found that a poor T cell response negatively correlated with patients' age a

195 Prior to immunotherapy, mite-induced Th-cell response networks involved multiple discrete co-exp

196 Tissue-specific CD45(+) immune cell responses occurred at the time of peak disease seve

197 transient boost of the SIV-specific CD8(+) T cell responses occurred in IL-2-DT-treated RMs.

198 reases in pathogen-specific functional CD4 T-cell responses on ART, and early decreases in lung funct

199 asticity and shape both local and systemic T cell responses on reinfection.

200 participants had significantly higher CD8+ T-cell responses (P = .03).

201 T-cell responses peaked at day 14 after a single standard

202 the ChAdOx1 nCoV-19 group, spike-specific T-cell responses peaked on day 14 (median 856 spot-forming

203 H-2D(b) on CD11c(+) APCs mitigates the CD8 T cell response, preventing early viral clearance and immu

204 Glycopeptide-induced CD4(+) T cell response prior to Env trimer immunization elicits n

205 We profiled genome-wide allergen-induced Th-cell responses prospectively during 24 months subcutaneo

206 able to activate tumor neoantigen-specific T cell responses, providing a potent, individual tumor-spe

207 CD4+ T-cell response rates were higher at month 18 than month 1

208 ntiviral responses and SARS-CoV-2-specific T cell responses remained similar between the two groups.

209 y which the OX40 cosignaling regulates the T-cell response remains obscure.

210 itumor immunity, but promoting durable CAR T cell responses remains challenging.

211 te and coordinate alphabeta and gammadelta T cell responses remains unknown.

212 )TNFalpha(+) and IFNgamma(+) IL2(+) CD4(+) T cell responses respectively, in comparison to 33% and 13

213 he CNS is cleared in C57BL/6 mice by a CD8 T cell response restricted by the MHC class I molecule H-2

214 Many epitope-specific CD8 T cell responses restricted by these four MHC molecules ha

215 ture assay was also used to analyze memory T cell responses.RESULTSWe found responses to the spike pr

216 tween them, polyfunctional gE-specific CD4 T-cell responses, safety, and confirmed HZ cases were asse

217 c model of TCR signaling in which multiple T cell responses share a common rate-limiting threshold an

218 Current immunotherapies involving CD8+ T cell responses show remarkable promise, but their effica

219 The B cell response showed converging IGHV3-driven BCR cluster

220 57:01-restricted, HIV epitope-specific CD8 T-cell responses showed beneficial functional patterns and

221 y directed and functionally replete memory T cell responses, suggesting that natural exposure or infe

222 rance to livers, likely due to greater CD8 T cell responses than in the kidney model.

223 sults in a CXCR5+ CCR7+ Tfh/central memory T cell response that persists well after parasite clearanc

224 CSP has been shown to induce robust CD8(+) T cell responses that are capable of eliminating developin

225 childhood can establish long-lived memory B cell responses that can be recalled later in life.

226 phagy is recognized as one component of host cell responses that has an essential role in innate and

227 The Matrix-M1 adjuvant induced CD4+ T-cell responses that were biased toward a Th1 phenotype.

228 We performed detailed characterization of B cell responses through high-dimensional flow cytometry t

229 idin (SA-PDL1) that inhibited the T effector cell response to alloantigens and converted T convention

230 ivation that primes a Tc1-polarized CD8(+) T cell response to bolster tumor rejection.

231 ts that are functionally relevant in the BTC cell response to chemotherapy.

232 ide the first glimpse of the overall human T cell response to HPV in a clinical setting and offer gro

233 l function, but the complexities of the stem cell response to increases in damaged or aggregated prot

234 ivated a marked interferon gamma-secreting T-cell response to M1 peptides.

235 e regulator of the early innate gammadelta T cell response to mucosal injury.

236 sequence diversity, the ability of the CD8 T-cell response to recognize several variants of a single

237 CD8+ T cell response to vaccination is impaired as a result of

238 As reviewed herein, the T-cell response to vaccination requires a fine balance bet

239 whether nitric oxide contributes to the beta-cell response to viral infection.

240 T-cell responses to 50 frequently recognized Amb a-derived

241 play partially redundant roles to restrain B cell responses to antigen in the absence of co-stimulati

242 at can substantially alter the outcomes of B cell responses to complex antigens.

243 on also reported Notch signaling in CD8(+) T cell responses to dendritic cell immunization, Listeria

244 s of M.tb infection and BCG vaccination on B cell responses to heterologous pathogen recall antigens.

245 r a bystander effect leading to additional T cell responses to nonviral tumor-associated antigens thr

246 performed high-throughput analysis of single-cell responses to odor blends using Swept Confocally Ali

247 pe 1 diabetes is characterized by effector T-cell responses to pancreatic beta-cell-derived peptides

248 Epitope density has a profound impact on B cell responses to particulate Ags, the molecular mechani

249 Assays to study cancer cell responses to pharmacologic or genetic perturbations

250 nce prevents autoimmunity, but also limits T cell responses to potentially immunodominant tumor epito

251 ers with T1D had reduced cord blood CD4(+) T-cell responses to proinsulin and insulin, a reduction in

252 T cells, and improved regulation of CD4(+) T cell responses to proinsulin at 9 months of age, as comp

253 uppressing the activation of inappropriate T cell responses to resident microorganisms.

254 ed HLA-B*57:01-restricted HIV-specific CD8 T-cell responses to responses restricted by other HLA clas

255 Overall, T cell responses to SARS-CoV-2 are robust; however, CD4(+)

256 tudies have highlighted various aspects of T cell responses to SARS-CoV-2 infection that are starting

257 to develop vaccines that can also mediate T-cell responses to SARS-CoV-2 to limit severity of infect

258 amma release assay (IGRA) for detection of T cell responses to SARS-CoV-2.

259 Recently, we showed they can also rewire T-cell responses to soluble ligands.

260 Refractory B cell responses to T cell-independent (TI) carbohydrate a

261 es of hospitalization and decreased memory T-cell responses to tetanus vaccine were associated with H

262 en focused on HCoV-NL63 and detected broad T cell responses to the spike protein and identified 22 ta

263 ling alterations that could influence cancer cell responses to the tumor mechanical microenvironment

264 defective ECTV-specific CD8(+) and CD4(+) T-cell responses to WT ECTV.

265 However, the cells' response to a drug is typically quantified by a s

266 etabolomics and genetics to characterize the cells' response to acute glucose depletion and identify

267 -cells is hypothesized to trigger a CD8(+) T-cell response underpinning the hypersensitivity.

268 T cell responses upon infection display a remarkably repro

269 dic technology to study time-resolved single-cell responses upon PM exposure.

270 A vigorous anti-donor type T cell response was detected in vitro and conventional imm

271 es to wild-type mice, suggesting that this B cell response was independent of cognate T cell help.

272 The boost of MAIT cell responses was dependent on strongly enhanced MR1-me

273 is, the ability of VISTA to restrain naive T cell responses was lost under inflammatory conditions.

274 In 3 patients, virus-specific T-cell responses were analyzed using T-cell enzyme-linked

275 Antibody and T-cell responses were assessed before upper- and lower-air

276 For 6 epitopes, CD8+ T-cell responses were confirmed in T cells derived from se

277 Optimal NK cell responses were dependent on IL-18 and IL-12, wherea

278 Increased CD4(+) T cell responses were detected in eight individuals.

279 SARS-CoV-2-specific T cell responses were driven by TCR clusters shared betwee

280 Antibody and T-cell responses were higher in the 1.8 x 106 PfSPZ group.

281 ent cohorts showed that alpha-syn-specific T cell responses were highest shortly after diagnosis of m

282 Total memory T-cell responses were measured after anti-CD3 or vaccinia

283 cited influenza-specific CD4(+) and CD8(+) T-cell responses were measured using flow cytometry and in

284 novo neoantigen-specific CD4(+) and CD8(+) T cell responses were observed post-vaccination in all of

285 eadth and overall strength of HPV-specific T cell responses were significantly higher before the comm

286 The breadth and magnitude of T cell responses were significantly higher in severe as co

287 5 enhanced splenic and vaginal Ag-specific T cell responses whereas CCL28 increased the levels of spe

288 ts in the medOB decreased the reticulospinal cell responses whereas the D2 receptor antagonist raclop

289 a high titer of neutralizing Abs but poor T cell responses, whereas Aer induced powerful respiratory

290 ht of 'protective' or 'detrimental' CD8(+) T cell responses which are restricted by the host HLA clas

291 from a single construct to achieve enhanced cell response while maintaining cellular heterogeneity d

292 chanisms through which NHERF1 modulates mast cell responses will lend insights into the development o

293 e range, multifunctional CD8(+) and CD4(+) T cell responses with S protein-specific killing activity

294 tested for their effect on the size of the T cell response, with a>=50% loss defined as an escape mut

295 CD2 downregulation may attenuate antitumor T cell responses, with implications for checkpoint immunot

296 Sex had an impact on all beta-cell responses, with male animals exhibiting greater met

297 -valency antigens induced smaller effector B cell responses, with preferential recruitment of high-af

298 s to the development of a strong anti-ZIKV T-cell response without eliciting significant anti-ZIKV an

299 B*52:01-restricted p24 Gag-specific CD8(+) T-cell response without incurring a significant loss to vi

300 ble of dissecting physiologically relevant B cell responses without the use of an engineered BCR.