ライフサイエンスコーパス: cell shape

1 ision are dynamically determined by daughter cell shape.

2 The resulting patterns are dictated by cell shape.

3 in cell division, intracellular traffic, and cell shape.

4 late nucleus pulposus cell phenotype through cell shape.

5 Cell migration involves dynamic changes in cell shape.

6 contact and is associated with changes in T cell shape.

7 a, resists the effects of turgor and confers cell shape.

8 Bacterial peptidoglycan maintains cell shape.

9 chromosome in live E. coli with a broadened cell shape.

10 whereas retraction involves only changes in cell shape.

11 to their environments that manifest in their cell shape.

12 wever, N-cadherin has an indirect control on cell shape.

13 and cell wall synthesis, cell division, and cell shape.

14 morphology, causes ER stress and defects in cell shape.

15 ontrol lobe formation and determine pavement cell shape.

16 l approach to study the mechanisms governing cell shape.

17 e funis, defective axoneme exit, and altered cell shape.

18 drive cytoskeletal rearrangements to change cell shape.

19 (PG) cell wall is the primary determinant of cell shape.

20 y alter cortical organization, mechanics and cell shape.

21 structures crucial for force generation and cell shape.

22 d model parameters that significantly affect cell shape.

23 ulate cellular, molecular signalling through cell shape.

24 n assembly dynamics underlie many changes in cell shape.

25 tect the cell from bursting and maintain its cell shape.

26 eton plays a key role in establishing robust cell shape.

27 Escherichia coli, little is known about most cell shapes.

28 es match those calculated from instantaneous cell shapes.

29 ich modulate GREM1 expression and epithelial cell shapes.

30 SBRs, cell densities, labeling methods, and cell shapes.

31 echanism for the generation of complex plant cell shapes.

32 otemporal organization to reproduce specific cell shapes.

33 To better understand pavement cell-shape acquisition and the role of auxin in this pro

34 The diversity of cell shapes across the bacterial kingdom reflects evolut

35 rix (ECM) are critical for the regulation of cell shape, adhesion, and migration.

36 Cell shape, adhesion, and motility have a complex relati

37 nic development by governing key elements of cell shape, adhesion, migration and differentiation.

38 ow a systems level phenomenon whereby global cell shape affects subcellular organization to modulate

39 is their shape, but we do not understand how cell shape affects the dense communities, known as biofi

40 into how Notch signals are triggered and how cell shape affects these events, and we use the new insi

41 show that, in contrast to isotropic tissues, cell shape alone is not sufficient to predict the onset

42 We show that changes in cell shape and alignment over time in the Drosophila ger

43 are critical for cell envelope integrity and cell shape and also represent key antigenic determinants

44 iclinal microtubules are not correlated with cell shape and are unstable at the time scales of cell e

45 unknown regulatory pathways to couple their cell shape and associated attributes to the temperature

46 es for the coordination and control of plant cell shape and cell growth.

47 noi (SPV) model that links cell mechanics to cell shape and cell motility, we formulate a generalized

48 sphatases (GTPases) are master regulators of cell shape and cell movement [1].

49 Cell shape and cell-envelope integrity of bacteria are d

50 le for microtubules for maintaining skin TRM cell shape and cellular integrity.

51 sin-II (Myo-II) activity, coordinates border cell shape and cluster cohesion.

52 n act as a proprioceptive device: they sense cell shape and control actomyosin retraction to sustain

53 ith a dynamic phase field to account for the cell shape and demonstrate that daughter cells emerging

54 rs ago as essential genes for the asymmetric cell shape and division of budding yeast.

55 RBCs to shear flow and probe the effects of cell shape and effective membrane viscosity on their tan

56 to reveal the physical processes underlying cell shape and forces, but it is notoriously difficult t

57 nner, thereby allowing temperature to govern cell shape and gene expression in this ubiquitous fungal

58 role for the funis in establishing Giardia's cell shape and guiding axoneme docking.

59 ex attachment plays key roles in controlling cell shape and integrity.

60 of the actin cytoskeletal and, thereby, the cell shape and invasive growth potential of tumor cells.

61 macromolecule peptidoglycan, which maintains cell shape and is responsible for resisting osmotic stre

62 ons are frequently accompanied by changes in cell shape and mechanics.

63 pression profiles for putative regulators of cell shape and meristem determinacy as well as a general

64 rchitecture of the ECM promotes an elongated cell shape and migration along the fibrils.

65 down in wild-type fibroblasts showed altered cell shape and migration, consistent with known roles of

66 T cells displayed significant alterations in cell shape and motility parameters in vivo but showed co

67 l family kinases are essential regulators of cell shape and movement.

68 h mitosis undergo precisely timed changes in cell shape and organisation, which serve to ensure the f

69 Analyzing the contributions of cell shape and organization to the morphogenesis of smal

70 yer is responsible for maintaining bacterial cell shape and permitting cell division.

71 , we found a very strict correlation between cell shape and physiological response and selected seven

72 cellular functions, including regulation of cell shape and polarity, cytokinesis, cell migration, ve

73 junctions (AJs) remodel to allow changes in cell shape and position while preserving adhesion.

74 in cytoskeleton to ensure correct epithelial cell shape and prevent epithelial-to-mesenchymal transit

75 ria with the mechanical strength to maintain cell shape and resist osmotic stress.

76 he objective, 3D analysis of the coupling of cell shape and signaling.

77 contrasts to differentiate features such as cell shape and size can be generated directly by signal

78 reasons for the disparity are variations in cell shape and size, as well as biological reasons such

79 emporal control predict distinct patterns of cell shape and size, which were tested experimentally by

80 Quantitative 3D analysis of cell shape and spindle positioning allows us to infer mu

81 raphy, and internal physical states, such as cell shape and spreading area.

82 , an adaptable enclosure that contributes to cell shape and stability.

83 ect cycadalean affinities, whereas its guard cell shape and stomatal ledges are angiospermous.

84 g/mL for 24 h) produced small alterations in cell shape and that as the dose was increased, cell spee

85 n cytoskeleton is a structure that gives the cell shape and the ability to migrate.

86 Thus, forces are key regulators of stem cell shape and the targeted engineering of specific MSC

87 sed because of normally occurring changes in cell shape and tissue tension.

88 as a potential driving force in establishing cell shape and topology within tissues.

89 porter in nascent mesoderm enabled recording cell shape and trajectory through live imaging.

90 mp that maintains intracellular homeostasis, cell shape and turgor under conditions in which potassiu

91 We quantified cell shapes and actin and myosin distributions in differ

92 eveal an unprecedented role of N-cadherin on cell shapes and cell arrangements.

93 homeostasis, how adhesion molecules control cell shapes and cell patterns in tissues remains unclear

94 Cell shapes and connectivities evolve over time as the c

95 stence of specific mechanisms that stabilize cell shapes and counteract cell elasticity.

96 The model faithfully reproduces typical cell shapes and movements down to the level of single ce

97 defects are likely a consequence of abnormal cell shapes and not due to TAN1 absence.

98 segmented and assigned to brain regions, and cell shapes and volumes to be computed for motor neurons

99 air-1(RNAi) embryos occurs effectively in a cell-shape and curvature-dependent manner.

100 ractile ring and cortex do contribute to the cell shape, and can work together with water permeation

101 cell cortex is essential to maintain animal cell shape, and contractile forces generated within it b

102 Arabidopsis altered cellular MT orientation, cell shape, and organ morphology.

103 Our results reveal the diversity of pavement cell shapes, and lays the quantitative groundwork for te

104 tiotemporal fields of cell migration speeds, cell shapes, and traction forces measured simultaneously

105 aracterized by weak adhesion, highly dynamic cell shapes, and ubiquitous motility on two-dimensional

106 ges are characterized by particular pavement cell shapes; and second, that undulatory cell shapes are

107 While the Rod complex governs rod-like cell shape, aPBP function is less well understood.

108 Helical cell shape appears throughout the bacterial phylogenetic

109 These changes in cell shape are both influenced by, and feed back onto EC

110 Dramatic and rapid changes in cell shape are perhaps best exemplified by phagocytes, s

111 We find that apical cell shapes are abnormal in sdk mutants, suggesting a de

112 ent cell shapes; and second, that undulatory cell shapes are common enough to be model shapes.

113 These studies build on the view that cell shape arises from the physical properties of an ela

114 We track changes in cell shape as cells deform into microfluidic constrictio

115 This suggests the chiral T. brucei cell shape (associated with the lateral attachment of th

116 However, cell shape-based modeling indicates that PPB positioning

117 bility of bacteria and in defining bacterial cell shapes, both of which are important for existence i

118 els that aPBPs do not contribute to rod-like cell shape but are required for mechanical stability, su

119 ession does not have an elongating effect on cell shape but instead is associated with loss of actin

120 riaxone), amikacin and phages did not modify cell shape but produced intracellular inclusion bodies.

121 inhibits gut colonization, not by effects on cell shape, but by activating the expression of a hypha-

122 eB directs cell-wall insertion and maintains cell shape, but it remains unclear how structural change

123 We show that cell shape, but not size, changes with resource levels a

124 , that are required for polarized growth and cell shape, but their functional mechanisms and connecti

125 ily actin polymerases, for example, modulate cell shape by accelerating actin filament assembly local

126 rces are known to play a major role in plant cell shape by controlling the orientation of cortical mi

127 Bacteria maintain cell shape by directing PGN incorporation to distinct re

128 we probe the effects of mechanical strain on cell shape by modelling the mechanical strains caused by

129 rotubules at the plant cell cortex influence cell shape by patterning the deposition of cell wall mat

130 an essential role for spectrin in specifying cell shape by transmitting intracellular actomyosin forc

131 In animals, it is well established that cell shape can also influence cytoskeletal organization.

132 Intricate patterns of cell shape can be analyzed and classified using advanced

133 relationships, we find that information from cell shape can be resolved from mechanical signals.

134 such structures to show that a complex plant cell shape can derive from chemically induced local and

135 Highly symmetric cell shape can give highly directional swimming but is a

136 on indicated hydrodynamic drag on the chiral cell shape caused rotation, and the predicted geometry o

137 Here we use SEGGA to analyze changes in cell shape, cell interactions and planar polarity during

138 to analyze specific characteristics such as cell shape, cell size, metaphase/anaphase delays, and mi

139 keleton-dependent cellular processes such as cell shape change and migration.

140 aces contributes to physiologically relevant cell shape change in intact organisms.

141 Apical constriction is a widely utilized cell shape change linked to folding, bending and invagin

142 body develop through complex coordination of cell shape change, cell migration, and cell proliferatio

143 urrow ingression during cytokinesis, a model cell-shape-change process.

144 we investigated how physiologically relevant cell shape changes affect subcellular organization, and

145 During development, coordinated cell shape changes and cell divisions sculpt tissues.

146 behaviors have been extensively studied, how cell shape changes and cell divisions that occur concurr

147 This requires dramatic cell shape changes and cell movements, powered by the co

148 herin and Sox2), actomyosin disorganisation, cell shape changes and diminished resistance to neural f

149 sing at focal adhesions in the regulation of cell shape changes and polarity.

150 etworks driven by myosin activation controls cell shape changes and tissue morphogenesis during anima

151 Although these cell shape changes are accompanied by an apparent large

152 These cell shape changes are controlled by nonmuscle myosin II

153 Cell shape changes are determined by the interplay of ce

154 Cell shape changes are vital for many physiological proc

155 Cell shape changes during cytokinesis in eukaryotic cell

156 t initiate the regulation of NMII to mediate cell shape changes during MHB morphogenesis are not know

157 orming isoform M23-AQP4 (AQP4-OAP) triggered cell shape changes in glioma cells associated with alter

158 suggests that these MyosinII meshworks drive cell shape changes in response to external forces, and t

159 ubule/actin filament interactions underlying cell shape changes in response to guidance cues, plays a

160 ctomyosin cortical contractility drives many cell shape changes including cytokinetic furrowing.

161 Specific cell shape changes occur at the point of deepest constri

162 tion from alveolar type I and type II cells, cell shape changes of type I cells and migration of myof

163 Dynamical cell shape changes require a highly sensitive cellular s

164 Cell shape changes such as cytokinesis are driven by the

165 essential to driving the cell movements and cell shape changes that generate tissue structure.

166 Epithelial organ size and shape depend on cell shape changes, cell-matrix communication, and apica

167 matis entry into HeLa cells resulted in host cell shape changes, whereas the tarP mutant did not.

168 equires tight spatiotemporal coordination of cell shape changes.

169 axis is cancelled by cell rearrangements and cell shape changes.

170 on, a process driven by asymmetric epidermal cell shape changes.

171 twork that regulate NF-kappaB in response to cell shape changes.

172 At the core of cell-shape changes is the ability of the cell's machiner

173 unfolding allows bleb inflation and dynamic cell-shape changes performed by migrating cells.

174 describe a model in which cell polarity and cell shape compete to determine the orientation of cell

175 ed quantitatively how chirality in T. brucei cell shape confers highly directional swimming.

176 Thus, helical cell shape contributes to tissue interactions that promo

177 ctin) networks facilitate key processes like cell shape control, division, polarization and motility.

178 uncover an essential mechanism that couples cell shape, cortical tension, and Hippo signaling and hi

179 oskeletal protein MreB for subtle changes in cell shape, cumulatively spanning approximately 5-fold v

180 zation and quantification of fine details in cell shape, cytoplasm, nucleus, lipid bodies and cytoske

181 To investigate how cell shape, cytoskeletal organization, and molecular mot

182 extracellular force has a profound effect on cell shape, cytoskeleton tension, and cell proliferation

183 These parasites have cell shapes defined by a subpellicular microtubule array

184 However, interphase cell shapes demonstrate the opposite bias.

185 We show that cone cell shapes depend little on adhesion bonds and mostly o

186 at it is driven by classic actomyosin-driven cell shape-dependent mechanisms.

187 and subcellular processes underlying complex cell-shape determination in plants.

188 s in cell division as the counterpart of the cell shape-determining actin homolog MreB in cell elonga

189 eight crystal structures for a member of the cell-shape-determining class of Campylobacter jejuni, th

190 ulated by a paracrystalline, protective, and cell-shape-determining proteinaceous surface layer (S-la

191 lpha proteins promote dynamic adjustments of cell shape directed by actin-cytoskeleton reorganization

192 in cytoskeleton is of profound importance to cell shape, division, and intracellular force generation

193 ellular debris requires a dramatic change in cell shape driven by actin polymerization.

194 hogenesis arises from coordinated changes in cell shape driven by actomyosin contractions.

195 these data strongly suggest that changes in cell shape, driven by gene expression and/or mechanical

196 li that grow at a similar rate but differ in cell shape due to single amino acid changes in the actin

197 o stabilize the cleavage furrow and maintain cell shape during cytokinesis [1-14].

198 er phase also play a role in determining the cell shape during cytokinesis.

199 cytoskeleton that are essential to maintain cell shape during infection.

200 Amoeboid cells change their cell shape during locomotion and in response to external

201 quired to maintain cellular organisation and cell shape during morphogenesis.

202 regulates cytoskeletal processes that govern cell shape during neural tube closure.

203 cytokine expression, matrix remodeling, and cell shape dynamics.

204 le of the cell apex (medioapical) can change cell shape (e.g., apical constriction) but can also resu

205 e in regulating the broad characteristics of cell shape (e.g., expansive, contractile, polarized, etc

206 gradation, matrix remodeling, and changes in cell shape each require cells to expend energy.

207 hat a 2-mum spacing is sufficient to promote cell shape elongation and migration parallel to the ECM,

208 lopment, already before the typical pavement cell shapes emerge, with topological homeostasis maintai

209 network to identify fundamental distance and cell-shape features associated with cognate help (cell-d

210 ng matrix rigidity or micropatterning primed cell shapes, fibroblast activation levels can be increas

211 demonstrate that the glycocalyx can regulate cell shape from the outside in.

212 ll shape in normal gravity and this deformed cell shape got rescued to normal one by applying microgr

213 tion and resulting magnetotaxis is linked to cell shape has remained elusive.

214 Numerous methods for describing and modeling cell shape have been described, but previous evaluation

215 Quantitative analysis of cell shape helps to reveal the physical processes underl

216 computationally complex due to the variable cell shape, here we exploit the spherical symmetry of tu

217 Learning rules by which cell shape impacts cell function would enable control of

218 ated the interplay between cortical cues and cell shape in a proliferating tissue.

219 Our results demonstrate regulation of cell shape in bacteria is a mechanism to increase fitnes

220 st these assumptions, we quantified pavement cell shape in epidermides from the leaves of 278 vascula

221 ouse stomach, highlighting the importance of cell shape in infection.

222 embles into dynamic polymers that coordinate cell shape in many bacteria.

223 pression decreases cell migration and alters cell shape in NIH3T3 fibroblasts.

224 regulator FtsZ, which resulted an elongated cell shape in normal gravity and this deformed cell shap

225 cellular matrix function may similarly guide cell shape in other kingdoms, including Animalia.

226 nscription, signaling, myosin activation and cell shape in the Drosophila mesoderm.

227 ally, we demonstrate that the CVM influences cell shape in the TVM, and a loss of CVM results in TVM

228 ance of non-AJ membrane domains in dictating cell shape in tissue morphogenesis.

229 We demonstrate that cell shape in V. cholerae is regulated by the bacterial

230 Here we identify a network that stabilizes cell shapes in C. elegans embryos at a stage that involv

231 extending tissue, causes the abnormal apical cell shapes in sdk mutant embryos.

232 autoencoders to build generative models for cell shapes in terms of the accuracy with which shapes c

233 ally accessible metrics of cell patterns-the cell shape index and a cell alignment index-are required

234 We conclude that 3-D cell shape information, transduced through tension-indep

235 offer a mechanism for translating changes in cell shape into dramatic intracellular remodeling.

236 Bacterial cell shape is a genetically encoded and inherited featur

237 andmark features, and finding constraints on cell shape is a non-trivial task.

238 ming path geometry showed that highly chiral cell shape is a robust mechanism through which microscal

239 This work indicates cell shape is a stronger indicator of SRF and TEAD mecha

240 Finally, we found that mitotic cell shape is also abnormal in the mutant VZ.

241 Cell shape is controlled by the submembranous cortex, an

242 f biofilm matrix components, indicating that cell shape is coregulated with V. cholerae's induction o

243 Helical cell shape is necessary for efficient stomach colonizati

244 to be influenced in all these bacteria when cell shape is perturbed, consequences on niche colonizat

245 Cell shape is regulated by cell adhesion and cytoskeleta

246 Helical cell shape is thought to facilitate H. pylori's ability

247 Cell shape is well described by membrane curvature.

248 We also found that the distribution of cell shapes is hollow: most shapes are very different fr

249 or PI4KIIIbeta and PI4P in cell adhesion and cell shape maintenance.

250 okaryotic cells, including cellular defense, cell-shape maintenance, and regulation of import and exp

251 ontaneous activity of the sensory inner hair cells shapes maturation of the developing ascending (aff

252 ggested that nanoridge formation and conical cell shape may contribute to the reduction of physical a

253 nally, Rab35 represents a common contractile cell-shaping mechanism, as mesoderm invagination fails i

254 opment and adhesion strength, and determines cell shape, migration and differentiation.

255 lators of the cell cytoskeleton, controlling cell shape, migration and proliferation.

256 ol 4-kinase III beta (PI4KIIIbeta) regulates cell shape, migration, and focal adhesion (FA) number.

257 ically reduced amount of this protein alters cell shape, migration, proliferation, and gene expressio

258 omics analysis revealed a tight link between cell shape, molecular signatures, and phenotype.

259 o18Abeta than Myo18Aalpha, but no defects in cell shape, motility, or Golgi shape were detected.

260 t allows following five cellular parameters: cell shape, MT array, nucleus position, nucleolus positi

261 Recent exciting work characterizing cell shape mutants in a number of curved and helical Pro

262 H. pylori cell shape mutants show impaired colonization of the mou

263 nts, we find that neither changes in average cell shape nor oriented cell division are required for a

264 ular basis for the retention of the cuboidal cell shape observed in the Wt1KO epicardium.

265 When changes in cell shape occur, leading to a more spread, fibrotic mor

266 iated targets that promote an osteoinductive cell shape on fibrous scaffolds.

267 tify osteoinductive markers that also effect cell shape on fibrous topography.

268 tions of T2DM RBCs and explore the effect of cell shape on the fluctuation amplitudes.

269 physiological or pathological alterations in cell shape or movement.

270 ing cells tend to have strong asymmetries in cell shape or propulsion.

271 cellular functions including maintenance of cell shape, osmotic, and mechanical stability, the forma

272 timescales of minutes using only changes in cell shape over timescales of seconds.

273 f many organs in the body through changes in cell shape, polarity and behavior and is a major area of

274 , cell tracking and quantitative analysis of cell shape, polarity and behavior in epithelial tissues.

275 Cell shape provides both geometry for, and a reflection

276 Highly specific cell shape recognition can also be achieved by cell inte

277 that it encounters, but can information from cell shape regulate cellular phenotype independently?

278 -like MamK via distinct motifs, and with the cell shape-related cytoskeleton via MreB.

279 Furthermore, we investigate changes in cell shape, such as flattening, and show that this great

280 has demonstrated that individual features of cell shape, such as length or curvature, arise through t

281 rgic signaling is associated with changes in cell shape, such as process extension toward tissue dama

282 NAMPT inhibition extended beyond neoplastic cells, shaping surrounding immune effectors.

283 sociated fibroblasts (CAFs) acts on CD4(+) T cells, shaping T-cell polarization.

284 ess important than the carefully established cell shapes that direct them.

285 interactions between tumor cells and immune cells shape the tumor microenvironment.

286 nd other genetic models, we showed that Treg cells shaped the transcriptional landscape across multip

287 To understand how cell shapes, tissue organization, and cellular forces dr

288 ts influence on total cell cycle duration or cell shape to explain the observed changes in volume.

289 at couples specific aspects of breast cancer cell shape to signaling and transcriptional events.

290 nd physiological response and selected seven cell shapes to describe the molecular mechanism leading

291 even in regions where associated changes in cell shapes, traction forces, and migration velocities h

292 Many cell behaviors involve cell-shape transformations that impose considerable chan

293 m cell positioning, and cuboidal-to-squamous cell shape transitions in the extraembryonic serosa.

294 process, the regulatory pathways controlling cell shape transitions in V. cholerae and the benefits o

295 es pulsatile contractions to further remodel cell shape via mechanical ratcheting.

296 en turgor pressure, cell wall properties and cell shape, we focused on kidney-shaped stomata and deve

297 For complex 3D cell shapes, we developed a significant improvement of a

298 Clustering the surfaces into 28 archetypical cell shapes, we found a very strict correlation between

299 Our models predict that cell shape will strongly influence the fate of a cell li

300 at the simplest scenario to explain pavement cell shapes within an epidermis under tension must invol