ライフサイエンスコーパス: cell size

1 mble was robust to variation in proxies for "cell size".

2 n tau/tau(D) and can be much larger than the cell size.

3 g wild type-like mitochondrial structure and cell size.

4 to function as a metabolic sensor governing cell size.

5 eration capacity being maximized at a target cell size.

6 s a major role in controlling biogenesis and cell size.

7 DNA-content functions as a limiter of muscle cell size.

8 o vertebrates is that nuclear size scales to cell size.

9 theoretical limit with no observable bias by cell size.

10 resources to fitness at the cost of reduced cell size.

11 endoreplication to increment DNA content and cell size.

12 fy genetic factors associated with adipocyte cell size.

13 erges at stripe widths much greater than the cell size.

14 xpansion follows cell-cycle cues rather than cell size.

15 s modulate Pom1 mid-cell levels according to cell size.

16 ound to hold across 3 orders of magnitude in cell size.

17 on sarcomeric organization and cardiomyocyte cell size.

18 o make the Whi5 concentration independent of cell size.

19 docytic routes should also vary based on the cell size.

20 nal to cellular membrane content and thus to cell size.

21 mined at the single-cell level, primarily by cell size.

22 meric organization and reduced cardiomyocyte cell size.

23 g genes whose expression does not scale with cell size.

24 itochondria were similar, as was the overall cell size.

25 nsor that scales intracellular structures to cell size.

26 it appears linked to the average population cell size.

27 ule to adjust its geometry to changes in the cell size.

28 ins of the outer epidermal wall, and affects cell size.

29 , which are found to correlate well with the cell size.

30 how, in turn, mechanosensitivity scales with cell size.

31 her bulk density, lower expansion ratios and cell size.

32 at FA synthesis primarily determines E. coli cell size.

33 oordination of mRNA transcription rates with cell size.

34 hat control transcription rates scaling with cell size.

35 nother unidentified secreted factor controls cell size.

36 reaction type, reaction speed, crowding, and cell size.

37 e activity alone are capable of compensating cell size.

38 n, and spindle final length and scaling with cell size.

39 t subcellular structures adapt to a range of cell sizes.

40 eostasis, yielding a broader distribution of cell sizes.

41 ion is typically maintained across different cell sizes, a phenomenon known as scaling.

42 increased release rate was due to increased cell size accompanied by increased lysine utilization pe

43 mosome segregation scales to a wide range of cell sizes across different organisms and cell types.

44 ing two cycles, a division cycle controlling cell size and a DNA replication cycle controlling the nu

45 anarians, silencing results in a decrease in cell size and cell accumulation that ultimately produces

46 , but its activation is known to affect both cell size and cell number.

47 turally explained by the inheritance of both cell size and cell-cycle speed over several generations,

48 tially counteracted by aberrant increases in cell size and conductance.

49 lbumin-creatinine ratio (p = 0.041), average cell size and CV showed a positive correlation with thes

50 te regulates vegetative growth by modulating cell size and endoreplication.

51 pmental and homeostatic processes, including cell size and extracellular matrix remodeling.

52 RB overexpression increased cell size and G(1) duration, whereas RB deletion decreas

53 why bacterial aspect ratio is independent of cell size and growth conditions, and predicts cell morph

54 s mutant showed that ClpXP activity controls cell size and is required for growth at low temperature.

55 suggest that the quantitative laws governing cell size and its dependence on growth rate may arise as

56 t molecular crowding inversely correlates to cell size and might have an impact on spindle elongation

57 cell cycle arrest at S phase with increased cell size and nuclei.

58 enic HEK293 cells reveal that YAP can affect cell size and number by independent circuits.

59 es a key signaling mechanism for controlling cell size and number in organ growth.

60 lls to examine the coordinated regulation of cell size and number under the control of YAP.

61 Increased mesophyll cell size and palisade tissue thickness, in K-deficient

62 ts that are consistent with known changes in cell size and physiology.

63 -S606D knock-in mutant led to a reduction in cell size and proliferation.

64 results in growth defects by affecting both cell size and proliferation.

65 ted epidermal pavement cells, with increased cell size and reduced cell number per leaf blade with in

66 y weight, adipose tissue mass, and adipocyte cell size and reduced very low-density lipoprotein (VLDL

67 G(1) duration, whereas RB deletion decreased cell size and removed the inverse correlation between ce

68 , we uncovered a linear relationship between cell size and RNA content.

69 In plants, changes in cell size and shape during development fundamentally dep

70 version in EC morphological changes, such as cell size and shape that are altered in the absence of S

71 slational inhibitors cause strong effects on cell size and shape, as well as biofilm architectural pr

72 (RNAPII) transcription initiation rates with cell size and that RNAPII is a limiting factor.

73 ing approximately eight copies regardless of cell size and that the total number of clusters increase

74 Optimal cell performance depends on cell size and the appropriate relative size, i.e., scali

75 difficulties in the accurate measurement of cell size and the even greater challenges of measuring g

76 comparatively the functional consequences of cell size and their potential repercussions at higher sc

77 ion, altered leaf development with decreased cell size and viability, and early leaf senescence.

78 rocess with transcription rates scaling with cell size and without evidence for transcriptional off s

79 These metabolisms lead to increased cell sizes and abundances, resulting in bacteria consumi

80 We explain this result by differences in the cell sizes and check our hypothesis considering the self

81 croglia can thus be expected to have similar cell sizes and even distribution both across brain struc

82 ds on matrix porosity, matrix deformability, cell size, and cell deformability.

83 mia as a result of alpha-cell proliferation, cell size, and mass expansion.

84 tion capacities that vary monotonically with cell size, and non-monotonicity requires two key mechani

85 iological parameters, including growth rate, cell size, and photosynthetic activity over a wide range

86 However, separating cell size- and cell cycle-dependent growth is challengin

87 Surprisingly, although endoreplication and cell size are greatly reduced in lgo-2 mutant plants and

88 and the nuclear component(s) that scale with cell size are not known.

89 Individual cell sizes are variable and adaptable, but what governs

90 ltiple chemical and physical means ruled out cell size as a major determinant of nuclear size and gro

91 implicating the nucleocytoplasmic ratio and cell size as determinants of the intracellular organizat

92 ectopic fat, adipose tissue distribution and cell size as predictors of cardio-metabolic risk in 53 n

93 tal process responsible for creating sibling cell size asymmetry; however, how the cortex causes the

94 and removed the inverse correlation between cell size at birth and the duration of the G(1) phase.

95 sion protein FtsZ, we were able to oscillate cell size at division and systematically break the adder

96 and variability of its expression influence cell size at division.

97 nitiator protein DnaA caused oscillations in cell size at initiation but did not alter division size

98 How cells correct deviations from a mean cell size at mitosis remains uncertain.

99 of increased cell death or by a reduction in cell size because of atrophy.

100 n of ZGA whose onset tightly correlates with cell size but not with elapsed time or number of cell di

101 ononucleated cells, nuclear size scales with cell size, but does this relationship extend to multinuc

102 ethods exist to measure different aspects of cell size, but each has significant drawbacks.

103 Cell-cycle advancement is coupled with cell size, but it remains unclear how multiple cells int

104 ll-division-associated genes with respect to cell size, but not with respect to synchronization timin

105 malian cells exhibit remarkable diversity in cell size, but the factors that regulate establishment a

106 We showed that evolutionary shifts in cell size can alter the efficiency of DIC uptake systems

107 Analyses of cell size, cell walls and transcripts reveal barley COM1

108 colonies highlighted the variable nature of cell sizes, cell-cell contact networks, and colony arran

109 t, homeostasis, and repair entail epithelial cell size changes driven by mechanical forces; our work

110 During embryonic cell divisions, cell size changes rapidly in both C. elegans and zebrafi

111 .6-fold in the central cell, consistent with cell size changes.

112 henotype in iPSC-CMs that includes increased cell size, changes in cardiac gene expression, and abnor

113 m-state community with a broader spectrum of cell sizes coincides with indicators of carbon-cycle res

114 ome area scales more closely with changes in cell size compared to changes in spindle length.

115 by cell-free transcription-translation into cell-sized compartments, such as liposomes, is one of th

116 Fundamental mechanisms governing cell size control and homeostasis are still poorly under

117 Molecular mechanisms for cell size control have implications for how cell size re

118 logies establishing the diverse phenomena of cell size control in animal cells.

119 In this article, we discuss cell size control in plants compared with other organism

120 served correlations attributed to particular cell size control mechanisms, we identify dependencies t

121 ten relied on testing preconceived models of cell size control mechanisms.

122 cused on the mechanisms underlying bacterial cell size control, it remains largely unknown how the co

123 also shows remarkable plasticity in terms of cell size control, modes of cell division, and cell pola

124 tric variation can lead to new insights into cell size control.

125 how that a size-based probabilistic model of cell-size control at the G2/M transition (P(Div)) can ge

126 nistic model for multiple-fission cycles and cell-size control in Chlamydomonas.

127 cells and hint at intriguing similarities of cell-size control in different eukaryotic lineages.

128 ent noise sources in well-known paradigms of cell-size control, such as adder (division occurs after

129 ster cells are correlated beyond what single-cell, size-control models predict.

130 dels of cell-cycle regulation to explain how cell size controls passage through Start.

131 uthbrooding females, and gigantocellular AVT cell size correlated with the number of days brooding, s

132 gulation of gene expression as a function of cell size could affect many cellular processes.

133 l density (ECD), coefficient of variation in cell size (CV), cell area (CA) and percentage of regular

134 onal cell ratio decreased, while the average cell size, CV%, and central corneal thickness increased.

135 were significantly lower, while the average cell size, CV%, and central corneal thickness were deter

136 y integrating single-cell RNA sequencing and cell-size data, we provide insights into genes that are

137 antified key morphological changes including cell size decreases during apoptosis in responsive tumor

138 Using Bayesian analysis, we characterize the cell-size-dependent distributions of alpha that accurate

139 The cell-size-dependent expansion of the nucleoid is only mo

140 cle regulatory factor influencing ploidy and cell-size depending on external nitrate.

141 the degree of change and relationship to the cell size depends on cell types.

142 Investigations of E. coli cell size determinants showed that FA synthesis primaril

143 k for studying the fundamental principles of cell size determination in unicellular organisms.

144 ather than thermodynamics, biomass yield and cell size, determine the abundances of these main marine

145 For example, cell size determines the spatial scale of organelles and

146 membrane-related protein transport, and its cell size did not become larger in quiescence compared t

147 population is aggregated mainly rely on: (1) cell size distribution curves that are difficult to be c

148 -law statistics in the tail of C. crescentus cell-size distribution, although there is a discrepancy

149 ow small, fast-growing bacteria ensure tight cell-size distributions remains elusive.

150 interneuron myelination, enlargement of SOM+ cell size dramatically increased the frequency of myelin

151 ion and alter true biological features (e.g. cell size) due to our limited ability to interpret the e

152 e-dimensional changes and rapidly decreasing cell sizes during early development of the embryo.

153 anges in epithelial cell sizes-or epithelial cell size dynamics (ECD)-during morphogenesis entail int

154 Rather than scaling with cell size dynamics, these pulses follow the intrinsic me

155 presumed scaling of its production rate with cell size dynamics.

156 endothelial cell morphogenesis and increased cell size, ectopic sprouting, expanded vessel lumen diam

157 tes is associated not only with increases in cell size, enhanced adhesion, and reduced detachment fro

158 te ECD: higher cell-cell adhesion results in cell size enlargement.

159 istic of the angiosperm syndrome (e.g. small cell sizes, etc.) is hierarchical vein networks that all

160 g a near-constant ratio between nucleoid and cell size for a given species.

161 he GAL1 promoter, finding that the spread in cell sizes for an asynchronous population is unaffected

162 which complicates disentangling the role of cell size from other covarying traits.

163 ade-must scale and change in accordance with cell size, geometry, and function.

164 p to shed light on the relationships between cell size, growth and cycle progression.

165 sis with cell wall development and epidermal cell size has been identified.

166 are variable and adaptable, but what governs cell size has been unclear.

167 Cell size has previously been used to stratify Retinal G

168 Although some genes that affect mammalian cell size have been identified, the molecular mechanisms

169 eloping organs, vacuolization contributes to cell size heterogeneity and may resolve conflicts betwee

170 euromorphic computing, due to their smallest cell size, high write/erase speed and endurance.

171 In bacteria, this results in cell size homeostasis and periodicity in replication and

172 How organisms maintain cell size homeostasis is a long-standing problem that re

173 Cell size homeostasis is often achieved by coupling cell

174 to increased cell size, which suggests that cell size homeostasis requires coordinated control of pl

175 I5 inhibitor, or vice versa, interfered with cell size homeostasis, yielding a broader distribution o

176 ng-sought molecular mechanisms that promotes cell size homeostasis.

177 inhibition but also allows us to "reprogram" cell-size homeostasis in a quantitatively predictive man

178 nd that division processes exclusively drive cell-size homeostasis in bacteria.

179 M transition (P(Div)) can generate realistic cell-size homeostasis in silico.

180 Classical cell-size homeostasis models are the sizer, timer, and a

181 share a common phenomenological strategy for cell-size homeostasis under steady-state conditions.

182 ncreases, and this is sufficient to generate cell-size homeostasis.

183 oordinate growth and cell division to ensure cell-size homeostasis; however, the underlying mechanism

184 In animal cells, size homeostasis is controlled through two phenom

185 As seen from yeast cells to mammalian cells, size homeostasis is maintained cell autonomously

186 ncentration (i.e., diffusive tortuosity) and cell size (i.e., diffusion pathlength) and by comparing

187 We apply our method to examine how cell size impacts the cell division cycle and reaffirm t

188 ze of the membrane-bound nucleus scales with cell size in a wide range of cell types but the mechanis

189 he length of the mitotic spindle scales with cell size in a wide range of organisms during embryonic

190 ionship between growth, gene expression, and cell size in cyanobacteria.

191 tion of how mitotic spindle size scales with cell size in early zebrafish embryos reveals fundamental

192 , for the first time, we address the role of cell size in endocrine cell electrical activity, finding

193 sion biosynthetic capacity-positively impact cell size in organisms throughout the tree of life.

194 n complex 2; TORC2) controls growth rate and cell size in response to nutrient availability.

195 utational simulations to modulate epithelial cell size in silico and show that junctions between smal

196 lic acid cycle flux coupled with reduced fat cell size in subcutaneous WAT depots.

197 olithophores, can provide a rare window into cell size in the past.

198 nthetic hybrids, chromosomal instability and cell size increase dramatically as additional copies of

199 We find that under conditions where cell size increase is restrained, the nucleus becomes bi

200 r allele aged, nephrocyte function declined, cell size increased, and nephrocytes died prematurely.

201 a normal diet had increased white adipocyte cell sizes, increased numbers of inflammatory cells in a

202 a dedifferentiation process involving large cell size increases driven by Myc.

203 pressed in Arabidopsis, root apical meristem cell size increases, and morphogenetic capacity of cultu

204 Upon modest induction of FadR, cell size increases, but at the cost of growth rate and

205 rane, nucleoid size strongly correlates with cell size, independent of changes in DNA amount and acro

206 cambial zone and radial compression of xylem cell size, indicating that rapid tissue differentiation

207 Further, reducing cell size induces premature ZGA, dose dependently.

208 Cell size influences the rate at which phytoplankton ass

209 in Ca(V) 1.3(-/-) mice was the reduced hair cell size irrespective of their cochlear location.

210 How nuclear size is regulated relative to cell size is a fundamental cell biological question.

211 Cell size is a key characteristic that significantly aff

212 Cell size is believed to influence cell growth and metab

213 How cell size is determined and maintained remains unclear,

214 ze over time, supporting the notion that RGC cell size is dynamic in response to injury.

215 Proper cell size is essential for cellular function.

216 Cell size is fundamental to cell physiology because it s

217 Cell size is fundamental to cell physiology.

218 Cell size is important for cell physiology because it se

219 Why maintenance of a cell-type specific cell size is important remains poorly understood.

220 n a specific cell type and growth condition, cell size is narrowly distributed.

221 In proliferating cells, cell size is regulated by coordinating growth and divisi

222 Cell size is specific to each species and impacts cell f

223 propose that scaling of gene expression with cell size is the consequence of competition between gene

224 The scaling of organelles with cell size is thought to be exclusive to eukaryotes.

225 at the Cdr2 nodal density, which scales with cell size, is used by the cell to sense and control its

226 ntial scaling between protein production and cell size leads to a temporal increase in Cln3 concentra

227 increased axonal myelination, while reduced cell size led to decreased myelination.

228 time, completed cycles of cell division, and cell size may impact ZGA onset; however, the principal d

229 ethod by comparing it to several established cell size measurement strategies, including flow cytomet

230 akhpA mutations reduce growth rate, decrease cell size, minimally affect shape and induce expression

231 f sensory information through differences in cell size, myelination, and the expression of distinct r

232 show that inactivation of OpuD restores the cell size of a dacA mutant to near wild-type (WT) size,

233 This suggests that the cell size of denitrifying foraminifera is not limited by

234 In line, the cell size of SNORD42A deletion carrying leukemia cells w

235 to reduce cell division number and increase cell size of the small-size mutant mating type locus 3-4

236 5 mum-thick membranes are stable at lateral cell sizes of 5 mm by 20 mm.

237 The genetic control of the characteristic cell sizes of different species and tissues is a long-st

238 lect adaptations to the demands of different cell size or range of physiological growth temperatures.

239 convolution techniques due to differences in cell size or RNA-content, and we demonstrate how to addr

240 f cell organelles, or differences in sibling cell size or shape.

241 Spatiotemporal changes in epithelial cell sizes-or epithelial cell size dynamics (ECD)-during

242 ble substrates and structured into arrays of cell-sized pixels, this work opens a new pathway for the

243 ined, these results establish a link between cell-size pleomorphism and the control of epithelial cel

244 leading to artificial widening of DI versus cell size plots.

245 l chromosome segregation but also influences cell size, position, or fate [1].

246 CDC25 (Spcdc25) in tobacco results in small cell size, premature flowering and increased shoot morph

247 their growth rate to restrict the spread of cell sizes present throughout a population.

248 ing facilitated multiplex analysis of single cell-sized protein quantities to a depth of ~1 600 prote

249 andom variable whose distribution depends on cell size r.

250 ize fractions of the plankton defined by the cell-size ranges of their prymnesiophyte hosts.

251 the islet, which resulted from loss of islet cell size rather than islet cell number.

252 ing of the G0/G1 cell cycle phase leading to cell size reduction.

253 In the present study, we used cell size regulation to determine whether long-term modu

254 ka1 inactivation disturbed both temporal and cell-size regulation of expression.

255 Upregulation of cell size regulators in tetraploids, including TOR and O

256 by modulating DNA accessibility of hypocotyl cell size regulatory genes.

257 nct communities with small genomes and small cell sizes relative to those in ambient soils.

258 Control of cell size requires molecular size sensors that are coupl

259 cell size control have implications for how cell size responds to changes in ploidy, which are parti

260 ls, changes their phenotypes with respect to cell size, RNA, and protein content, and induces metabol

261 by mechanical forces that elicit changes in cell size, shape and motion.

262 l a heterogeneous population with respect to cell size, shape, vesicle number, size, and contents.

263 ing lines displayed significant increases in cell size, succulence and decreased intercellular air sp

264 Giant unilamellar vesicles (GUVs) are model cell-sized systems that have broad applications includin

265 at the cortex to promote mitotic entry at a cell size that can be modified by nutrient availability.

266 of crystals and the large molecular and unit cell size that influence data collection and analysis.

267 predicted a relationship between ploidy and cell size that was observed in yeast and aneuploid cance

268 y correlations over distances of ten or more cell sizes that are reminiscent of supercooled liquids a

269 ereas, in a tighter packing (7% smaller unit cell size), the hula-twist occurs.

270 spindle elongation is regulated: coupled to cell size, the amount of kinesin-6 Klp9 molecules increa

271 ces pombe, which enters mitosis at a minimal cell size threshold.

272 phase nucleus and mitotic spindle scale with cell size through both physical and biochemical mechanis

273 nsity of cardiac innervation correlated with cell size throughout the myocardial walls in all mammali

274 Treatment was associated with an increase of cell size to a mean area larger than that observed at 18

275 omimetic delivery vectors that capitalize on cell size to provide therapeutic advantages for pulmonar

276 th laws relating ribosomal mass fraction and cell size to the growth rate.

277 we discovered a novel size law that connects cell size to the inverse of the metabolic proteome mass

278 wever, such models underestimate the role of cell size transient dynamics by excluding them.

279 pose an efficient approach for estimation of cell size transient dynamics.

280 ed microglial cell densities (the inverse of cell size) using immunocytochemistry to Iba1 in samples

281 in archaeal cell cycle events contribute to cell size variability and control.

282 id cell, and egg cell, consistent with their cell size variation.

283 Cell size varies during the cell cycle and in response t

284 Cell size varies greatly between cell types, yet within

285 ) guidance on stripe widths smaller than the cell size (w <= 160 mum), which is accompanied by bioche

286 Reduced cell size was observed for multiple vegetative cell type

287 enesis of stem explants, and in BY2 cultures cell size was reduced.

288 Mean cell size was smallest in heterografts and correlated ne

289 Subcutaneous adipose cell size was the strongest individual predictor of whol

290 lating cytoplasmic Xenopus egg extracts into cell-sized 'water-in-oil' droplets.

291 By manipulating cell size, we discovered that centriole number scales wi

292 e endothelial cell area and the variation in cell size were increased with aging.

293 istologic analyses confirmed cellularity and cell size were the likely underlying sources for the dif

294 , and this joint mechanism leads to a target cell size where cellular proliferation capacity is maxim

295 pindle length and spindle dynamics adjust to cell size, which allows to keep mitosis duration constan

296 that reduced endocytosis leads to increased cell size, which suggests that cell size homeostasis req

297 an expression level that equalizes the mean cell size with that of wild-type cells, the size distrib

298 Cells in growing populations maintain cell size within a narrow range by coordinating growth a

299 chanisms during cell cycle that maintain the cell size within a range from generation to generation.

300 A noninvasive method for monitoring cell size would be highly advantageous as a potential bi