ライフサイエンスコーパス: cell surface

1 gment holoreceptors that remain bound at the cell surface.

2 ses at least some of these proteins from the cell surface.

3 phate receptor-mediated endocytosis from the cell surface.

4 indicate that receptors can function at the cell surface.

5 ch are required for MHC-I trafficking to the cell surface.

6 -driven interaction of RET with GFRAL on the cell surface.

7 stress that breaks the mature F-pilus at the cell surface.

8 ed ability to anchor latent TGF-beta1 on the cell surface.

9 A-B*57:01 altering peptides displayed on the cell surface.

10 SCUBE and SHH, recruiting the complex to the cell surface.

11 ia expression of LDL receptors (LDLR) at the cell surface.

12 and key virulence factor PfEMP1 to the host cell surface.

13 for those that enhance TREM2 protein at the cell surface.

14 bserved when the channel is expressed at the cell surface.

15 utants in presenting latent TGF-beta1 to the cell surface.

16 ndosomes to a PI3K amplification loop at the cell surface.

17 esulted in the accumulation of IFITM3 at the cell surface.

18 n export by destabilizing ferroportin on the cell surface.

19 jor route for cargo internalisation from the cell surface.

20 in the abundance of cognate receptors on the cell surface.

21 enhance pertactin secretion to the bacterial cell surface.

22 hether LapA is retained or released from the cell surface.

23 d by assembly of curli amyloid fibres on the cell surface.

24 iated lipids and proteins from the bacterial cell surface.

25 ften modulate growth factor signaling on the cell surface.

26 g high-avidity molecular interactions on the cell surface.

27 zing intact non-MHC proteins on the opposing cell surface.

28 of large clathrin-containing "scars" on the cell surface.

29 ar fluid, potentially enabling action at the cell surface.

30 ibition of the TMK1 signaling pathway at the cell surface.

31 rely on global or local deformations of the cell surface.

32 ipids and E-cadherin molecules at the living cell surface.

33 nse sequence diverse peptide hormones at the cell surface.

34 o help direct 34 different proteins onto the cell surface.

35 me 2), which is expressed on the endothelial cell surface.

36 s often wrap membrane extensions around stem cell surfaces.

37 charge interactions with negatively charged cell surfaces.

38 g of FHR5 oligomers to C3b deposited on host cell surfaces.

39 in the 2D plane of the cortex can pattern 3D cell surfaces.

40 ein families are expressed on infected blood cell surfaces.

41 ative cellular settings and at physiological cell surface abundance.

42 domains increased receptor dimerization and cell-surface abundance.

43 ation, yet therapy-mediated removal from the cell surface activates cancer-protective beta-arrestin-b

44 MCAM (CD146) is a cell surface adhesion molecule that has been reported to

45 Integrins are the major cell surface adhesion receptors mediating cell-matrix ad

46 CS-assisted shRNA screens, we identified the cell-surface adhesion receptor CD44 as a key positive re

47 tion of aberrant trans-frame peptides at the cell surface after treatment with IFNgamma.

48 ificant investments in the identification of cell surface Ags, there is a paucity of targets that mee

49 aling pathways by forming a complex with its cell surface alpha-receptor, IL-11Ralpha, and the beta-s

50 actin-rich protrusions that extend from the cell surface and are important for cell-cell communicati

51 ependent IFN-I signaling originates from the cell surface and depends on MyD88; it involves combined

52 encoded RNAs that are stably attached to the cell surface and exposed to the extracellular space, her

53 glycoprotein promotes attachment to the host cell surface and fusion of the viral and host membranes.

54 expression of envelope (Env) trimers at the cell surface and increased Env incorporation into virion

55 regulate the translocation of CD107a to the cell surface and kill cellular targets, while NKG7 also

56 s required for sialic acid expression on the cell surface and mediate reovirus infection of microglia

57 ate, NV18.1, that down-regulate MR1 from the cell surface and retain MR1 molecules in the endoplasmic

58 etory pathway to generate diverse glycans on cell surface and secreted glycoproteins.

59 ubiquitous glycosaminoglycan located on the cell surface and tethered to proteoglycans such as synde

60 us iRhom1 and -2 proteins are present on the cell surface and that iRhom2 also is present on the surf

61 As a result of unequal ion fluxes across cell surface and TT membranes, limited diffusion may gen

62 lative to that of wild-type SERINC5 from the cell surface and with enhanced exclusion of the mutant p

63 ion as both a functional antigen receptor on cell surfaces and as secreted antibody.

64 nfluenza viruses and are widely displayed on cell surfaces and in secreted mucus.

65 Microbial communities inhabit algae cell surfaces and produce a variety of compounds that ca

66 ulting in significantly increased NIS at the cell-surface and markedly increased RAI uptake in mouse

67 ion of antigenic cargo, final release to the cell surface, and engagement with their cognate receptor

68 providing a first anchor of the virus to the cell surface, and further facilitate high-affinity bindi

69 ative LGR4 and LGR5 existed as dimers on the cell surface, and LGR5 interacted with both FZD and LRP6

70 or to areas of E2 expression on the infected cell surface, and LIF enhanced the antiviral effects of

71 f Salmonella Typhimurium to hydrophobic host cell surfaces, and contributes to efficient gut coloniza

72 d exhibit enhanced interactions with plasma, cell-surface, and intracellular proteins, which facilita

73 actan proteins (AGPs) are a diverse group of cell surface- and wall-associated glycoproteins.

74 distinguishing IPF MPCs from control (CD44, cell surface; and MARCKS, intracellular).

75 ted by sialidase pretreatment, which removes cell surface anionic sialic acid.

76 y of adoptive T cell therapies targeting the cell surface antigen CD19 has been demonstrated in hemat

77 ings identify ALPP2 as a true tumor-specific cell surface antigen whose tissue specificity enables th

78 e a Gram-negative cell envelope and a unique cell surface antigen; therefore, this approach should be

79 Identification of tumor-specific cell surface antigens has proven challenging, as the vas

80 eagent can directly be used for detection of cell surface antigens obviating the laborious steps of p

81 To identity novel mesothelioma cell surface antigens with broad subtype coverage and hi

82 mouse ROR2 but not human ROR1 or other human cell-surface antigens.

83 patient or donor T cells to target specific cell-surface antigens.

84 rfaces by preventing the inactivation of the cell-surface APC convertase.

85 eshwork in the cells' interior, MTs near the cell surface are preferentially aligned with the PM.

86 Although macromolecules on cell surfaces are predominantly targeted and drugged wit

87 cell, and ACE2, its docking site on the host cell surface, are extensively glycosylated, making them

88 We identified the proportion of exposed cell surface area as most closely correlating with the n

89 n the proximal end of the endodermis and the cell surface around the xylem.

90 Alternatively, polysaccharides hydrolyzed by cell-surface attached or free extracellular enzymes (ext

91 SBV cell surface attachment and entry were largely reduced u

92 Cell surface-based loss-of-function screens reveal that

93 dition of a 3-O-S HS 12-mer reduced both tau cell surface binding and cellular uptake.

94 , reduced 3-O-S levels of HS diminished both cell surface binding and internalization of tau.

95 natural transformation by extending from the cell surface, binding to exogenous DNA, and retracting t

96 we show that endogenous iRhom1 and -2 can be cell surface-biotinylated on mouse embryonic fibroblasts

97 Immunoprecipitations demonstrated close cell-surface BTN2A1-BTN3A1 association independent of P-

98 of the endoplasmic reticulum (ER) and to the cell surface, but not to mitochondria, endosomes, or lip

99 f Nef is to remove the CD4 receptor from the cell surface by hijacking clathrin- and adaptor protein

100 ce to a soluble form of PrP(C) shed from the cell surface by proteases in the A Disintegrin And Metal

101 e inner membrane and then transported to the cell surface by the LPS transport (Lpt) machinery.

102 ylated PrPC that had been liberated from the cell surface by the metalloproteinase, ADAM-10, in combi

103 signal transduction ligand that activates a cell surface calreticulin-mediated, proarthritogenic, bo

104 ediated ubiquitination and downregulation of cell surface CD98.

105 ing non-natural amino acid incorporation and cell surface click chemistry in bacteria with high-throu

106 Cell surface Cnx-ERp57 complexes reduce these extracellu

107 ver cancer cells but not hepatocytes display cell surface Cnx.

108 use outer membrane vesiculation to exchange cell surface components, thereby increasing survival dur

109 Interacting with Gq proteins, cell-surface D1-mGlu5 heteromers exacerbated PLC signali

110 These cell surface differences were also observed within EMP r

111 Cell surface display of EGFR is essential for cellular r

112 EHD1 and a potential EHD1 partner, RUSC2, in cell surface display of EGFR.

113 ntrolling TPP formation and transport to the cell surface, enabling us to propose an updated model of

114 the trans-Golgi network, granules, or at the cell surface/endosomes.

115 Furthermore, it can be used for cell-surface engineering, development of microarrays, an

116 arated from bystander T cells based on their cell-surface enzymatic fucosyl-biotinylation.

117 edures required for phosphoflow often affect cell surface epitopes or mAb conjugates, precluding the

118 of members of the Ig superfamily, including cell surface-exposed receptors.

119 We identified top GATA3-correlated cell surface-expressed genes in human ILCs by RNA sequen

120 94 x 10(-13)) and was associated with HLA-DP cell surface expression in healthy individuals (p = 2.04

121 Cell surface expression of ACE2 determines the tissue su

122 lammatory cytokine stimulation increased the cell surface expression of ICAM-1 and induced cell surfa

123 the mature protein, alpha1(Lys374Serfs)*(25) Cell surface expression of mutant murine GABA(A)Rs is se

124 ell surface expression of ICAM-1 and induced cell surface expression of P-selectin and VCAM-1.

125 y revealed that chlamydial infection induced cell surface expression of T-cell homing and activation

126 Cell surface expression of the alpha1 subunits and L-typ

127 T cells (TCR-T cells) are not restricted by cell surface expression of their targets and are therefo

128 ubset is IgM(+), but due to low/negative IgD cell surface expression, it was named B-cell IgD low (BD

129 virus from host cells by down-regulating the cell-surface expression of the host restriction factor t

130 cells may therefore utilize their TCR like a cell-surface Fab repertoire, somewhat analogous to engin

131 ese dynamic FtsZ assemblies is to sample the cell surface for the proper location for the Z-ring.

132 vivo chemico-genetic approach that applies a cell-surface fragment complementation strategy, Split-Tu

133 with C-terminal truncations showed increased cell surface Frizzled and Wnt/beta-catenin signaling and

134 Enzymatic removal of cell surface GAGs and genetic ablation that diminishes G

135 ls exhibited significantly reduced levels of cell-surface Gb3, and both AHR knockout HeLa cells and t

136 ognostically associated secreted factors and cell surface genes, and computationally reconstruct cros

137 rease in cellular GLUT4 protein and enhanced cell surface GLUT4 levels in response to AMPK activation

138 glycosylation but does not enter other major cell surface glycan types including Asn(N)-linked glycan

139 Various cell-surface glycans function as initial, usually low-af

140 Tumor cells express a unique cell surface glycocalyx with upregulation of sulfated gl

141 ncreasing incorporation of GalNAzMe into the cell surface glycoproteome.

142 T) PIGK in fibroblasts rescued the levels of cell surface GPI-APs.

143 We have discovered that (1) cell surface GRP78 (sGRP78) is expressed on iPSCs and is

144 This versatile method for profiling cell surfaces has the potential to advance understanding

145 gically extracellular compartments or on the cell surface; hence, diverse secretion systems evolved t

146 of the C-terminal domains of OPG is to bind cell surface heparan sulfate (HS), but the in vivo evide

147 s Disease (AD) is mediated by tau binding to cell surface heparan sulfate (HS).

148 y altering the number of transporters on the cell surface, however there is some disagreement on just

149 u interacted with human BST-2, downregulated cell surface human BST-2 expression, and facilitated HIV

150 Secreted MIF binds to cell-surface immune receptors such as CD74 and CXCR4.

151 They also displayed low Ki-67, CD49d, cell-surface immunoglobulin M (IgM) expression and IgM-s

152 expression of TMPRSS13 protein on the cancer cell surface in CRC patient samples; in contrast, the ma

153 strocytes resulted in their retention at the cell surface in the form of functional gap junctions ind

154 antibody bound to HLA antigens on the donor cell surface in their native conformation that is not im

155 pression of newly-discovered proteins on the cell surface in vivo.

156 argets tumors in vivo by anchoring to cancer cell surfaces in a pH-dependent manner.

157 phosphate (PI(4,5)P(2)), are enriched at the cell surface including sites of endocytosis.

158 signaling (MAVS)-dependent remodeling of the cell surface, increasing surface presentation of HLA pro

159 However, there is no reliable cell surface indicator of Notch signaling across activat

160 on and increased alphavbeta3 and alphavbeta5 cell surface integrin expression as a result of combined

161 nesis and remodeling or by signaling through cell-surface integrin receptors to promote cell adhesion

162 gnaling is generated and transduced from the cell surface into the intercellular space and will aid i

163 While MR1 egress to the cell surface is ligand-dependent, the ability of small-m

164 ve the iron-tipped tube across the bacterial cell surface, killing the bacterium.

165 factor signalling is also controlled at the cell surface level via binding to heparan sulfate proteo

166 Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glyc

167 Thus, BMP-9 levels can control cell surface levels of ALK-1, via CAV-1, to regulate bot

168 -associated, gingipain-dependent decrease in cell surface levels of the intercellular adhesion molecu

169 eover, RalGAPA1 deficiency clearly increased cell-surface levels of lipid raft components in detached

170 ationally modified and are required for TraA cell surface localization and function.

171 that modulate the biophysical properties and cell-surface localization of VGSC alpha subunits and par

172 lar trilineage differentiation potential and cell surface marker expression as bone marrow hMSCs.

173 eceptor superfamily member OX40 (CD134) is a cell surface marker that is highly specific for activate

174 single skeletal stem cell population through cell surface markers and the development of single-cell

175 functional phenotypes characterized by their cell surface markers and their cytokine profiles.

176 rences between these profiles, we identified cell surface markers, CD69 and CD36, whose genes were di

177 blood frequencies of MAIT cells, defined by cell surface markers, decline during tuberculosis (TB) d

178 Tumor cell-surface markers are usually overexpressed or mutate

179 nd proteomic approaches to identify specific cell-surface markers for cardiac PW1(+) cells and found

180 ytosis activity, viability and expression of cell-surface markers, from tens of thousands of single i

181 lar, the levels of antigen expression at the cell surface may determine antibody-mediated cell death.

182 stic insight into how O-glycan structures on cell surface modulate their sensitivity to apoptotic sti

183 ponses, regardless of cell type and targeted cell surface molecule, suggest the Type I and II curves

184 These studies provide insight about cell surface molecules that CHIKV binds, which could fac

185 Microorganisms have evolved specific cell surface molecules that enable discrimination betwee

186 The cell surface molecules that select interneurons to survi

187 hich police the peptide status presented via cell surface molecules.

188 eome-instructed in vivo screen identified 20 cell-surface molecules regulating neural circuit assembl

189 Applying this approach to neural cell-surface molecules, we identify thousands of unannot

190 BCR) signaling, although they do not express cell surface mu-heavy chain (muHC).

191 to a C-end rule (CendR) motif that binds to cell surface neuropilin-1 (NRP1) and NRP2 receptors.

192 identification and quantification of unique cell surface O-glycans from different cell lines and the

193 Cell surface O-glycans were then analyzed using a nanoLC

194 sults demonstrate that glioblastomas exploit cell surface O-linked glycans for local and distant immu

195 ormal tissues, but which is expressed on the cell surface of human embryonic stem cells and many canc

196 acterize the impact of oncogenic KRAS on the cell surface of intestinal epithelial cells.

197 sis includes TIMP-1/CD63 interactions at the cell surface of live cells.

198 aused the aggregation of EHV1 virions on the cell surface of RK13 cells.

199 e protein that is highly up-regulated on the cell surface of several human cancers, making it a promi

200 may mediate host-parasite interaction at the cell surface, offering promising targets for blocking th

201 We use this method, which we call cell surface optical profilometry (CSOP), to quantify th

202 ering the cells will be shuttled back to the cell surface or degraded by the lysosome.

203 structural homology searches reveal no other cell-surface or secreted domains in vertebrates that res

204 These cells have a unique cell surface phenotype and transcriptional signature, an

205 We show that the T(RM) cell surface phenotype develops by 2 wk postinfection, w

206 In addition, the cell-surface phenotype (CD28, CD127) memory subset marke

207 types (ACT) and complicate the automation of cell surface phenotyping.

208 ne phosphorylation motifs to the promiscuous cell-surface phosphatase CD45(2,3), which results in the

209 First, total synthesis of the cell surface phospholipomannan anchor [beta-Manp-(1 -> 2

210 of its coding gene dramatically reduced the cell surface poly-N-acetyl-lactosamine and led to hypers

211 O antigens are important cell surface polysaccharides in gram-negative bacteria w

212 iosynthesis and processing lead to decreased cell surface presence of GPI-anchored proteins (GPI-APs)

213 l non-amyloidogenic processing of APP at the cell surface promotes ferroportin stabilization to decre

214 We have investigated the utility of the cell surface protein CD26 to identify functionally disti

215 Dscam2 is a cell surface protein required for neuronal development i

216 Here we report that mice lacking CD137, a cell surface protein used in several studies as a marker

217 gglutinins to engineer a genetically encoded cell-surface protein barcoding system.

218 To achieve this, we first identified a cell-surface protein, PLPPR3, that allowed purification

219 Cell-surface protein-protein interactions (PPIs) mediate

220 new phage, carrying gene encoding a putative cell-surface protein.

221 lls (MSCs) are characterized by their unique cell surface proteins and aberrant signaling pathways.

222 Characterisation of cell surface proteins expressed by each subset is inform

223 own, and especially the identity and role of cell surface proteins that are responsible for sperm-egg

224 PORTANCE Human leukocyte antigens (HLAs) are cell surface proteins that regulate innate and adaptive

225 Repulsive guidance molecules (RGMs) are cell surface proteins that regulate the development and

226 uctures for the functional analysis of these cell surface proteins.

227 is invaluable for studying cell populations, cell-surface proteins are often integral markers of cell

228 Genes encoding cell-surface proteins control nervous system development

229 1 (NEGR1) and neurotrimin (NTM) are abundant cell-surface proteins found in the brain and form part o

230 ic KRAS alters the expression of a myriad of cell-surface proteins implicated in diverse biological f

231 PC population is proliferative and marked by cell-surface proteins, including PDGFRalpha, Sca1, and C

232 These data point to N-MADD-4B processing and cell-surface proteoglycan binding as two possible mechan

233 ic analysis reveals that Rab11b controls the cell surface proteome, recycling proteins required for s

234 The cell surface proteome, the surfaceome, is the interface

235 patiotemporally resolved approach to profile cell-surface proteomes in intact tissues.

236 ght the power of temporally resolved in situ cell-surface proteomic profiling in discovering regulato

237 s in surface ultrastructure with the loss of cell surface protrusions and poor aggregation, resulting

238 ich is up-regulated by HCC cells, stabilizes cell surface PVR, which interacts with TIGIT, an inhibit

239 tivating mutations in the type I BMP/TGFbeta cell surface receptor ACVR1, which over-activates signal

240 te with each other by direct binding between cell surface receptor and ligand pairs.

241 ay for MYXO-CTERM proteins by using the TraA cell surface receptor as a paradigm.

242 -converting enzyme 2 (ACE2) is the canonical cell surface receptor for SARS-CoV-2.

243 asis, mechanisms underlying the role of this cell surface receptor in CRC have not been defined.

244 CD229/LY9 is a cell surface receptor present on B and T lymphocytes tha

245 ceptor (ADR) selectively recognizes 4-1BB, a cell surface receptor temporarily upregulated by activat

246 s a molecular target; an epithelium-specific cell surface receptor that is low or undetectable in hea

247 gnal triggers cell polarization by promoting cell surface receptor-mediated nanoclustering of signali

248 sent an alternative approach for attenuating cell-surface receptor signalling, termed receptor inhibi

249 ing a relatively broad ligand specificity of cell-surface receptor(s).

250 Cell surface receptors and their interactions play a cen

251 Engagement of cell surface receptors by viruses is a critical determin

252 same cell, and interactions between JAM and cell surface receptors expressed on adjacent cells.

253 d Flo11A domains, provide a rationale of how cell surface receptors have evolved in microorganisms to

254 on adjacent cells, stabilization of adjacent cell surface receptors on the same cell, and interaction

255 ntegrins are a large family of heterodimeric cell surface receptors that bind prototypic ligands on n

256 Wnts are secreted proteins that bind to cell surface receptors to activate downstream signaling

257 Plants depend on various cell surface receptors to integrate extracellular signal

258 Modification of cell surface receptors with branched N-glycans coordinat

259 r signalling is dependent on the presence of cell surface receptors.

260 which disrupts the virus' ability to bind to cell surface receptors.

261 us deploys this strategy to bind strongly to cell surface receptors.

262 conformation that is no longer able to bind cell surface receptors.

263 ect relevance to the interaction of HCV with cell-surface receptors and neutralising antibodies.

264 This approach compels cis-ligation of cell-surface receptors containing ITAM, ITIM or ITSM tyr

265 Plexins are key cell-surface receptors of the semaphorin family of cell-

266 Cytokine signaling is transmitted by cell-surface receptors that function as biological switc

267 2) is initiated by virus binding to the ACE2 cell-surface receptors(1-4), followed by fusion of the v

268 meable, making them useful for modulation of cell-surface receptors, while monosulfonated BODIPY reta

269 tate high-affinity binding to virus-specific cell-surface receptors, while other glycans function as

270 s target the extracellular regions (ECRs) of cell-surface receptors.

271 are tuned to achieve processive shrinking of cell surfaces remains unclear.

272 s X in the intracellular granules and on the cell surface, respectively.

273 ual recycling of beta1 integrins back to the cell surface, resulting in defective FA reformation.

274 Cell-surface signaling (CSS) in Gram-negative bacteria i

275 demonstrate an interaction of EMP3 with the cell surface signalling molecule CD44.

276 It plays a variety of roles at the cell surface structure and is under discussion to be inv

277 A variety of cell surface structures dictate interactions between bac

278 sugar and its subsequent incorporation into cell-surface structures is implicated in a variety of ba

279 ge suggest that ALPPL2 could be an excellent cell surface target for therapeutic development against

280 1 (TFR1) is common across cancer and permits cell-surface targeting of specific therapies in preclini

281 verage other hallmarks of cancer or specific cell-surface targets are gradually finding a niche in th

282 Nanocarrier-mediated Dox delivery to cell-surface TFR1, therefore, warrants optimization as a

283 , and additional interacting proteins at the cell surface that influence the fidelity of insulin rele

284 ained introns can be presented on the cancer cell surface, the development of personalized cancer vac

285 ates the recycling of MR1 molecules from the cell surface through endosomal trafficking compartments

286 n in LANA expression and presentation on the cell surface through MHC class I.

287 The PAM is synthesized on the cell surface through nucleic acid assembly and hybridiza

288 ent attachment of targeting ligands at the T-cell surface through the application of SpyCatcher-SpyTa

289 18 regulates kinectin-1 transport toward the cell surface to form ER-FA contacts, thus promoting FA g

290 PrP(C) may be shed from the cell surface to generate soluble derivatives.

291 e endo-O-sulfatases are transported onto the cell surface to liberate the 6-sulfate groups from the i

292 -induced, sterol-dependent nanoclustering of cell surface transmembrane receptor kinase 1 (TMK1) is c

293 that in MDA-MB-231 breast cancer cells, the cell-surface transporter density (n) may decay with cell

294 SH dose (100 mU/ml) caused a 33% decrease in cell-surface TSHR.

295 lent tool for the discovery of overexpressed cell surface tumour antigens and the development of targ

296 mulated remodeling of peritoneal mesothelial cell surface ultrastructure via induction of tunneling n

297 and MMP-2,9 gelatinase activity adjacent to cell surfaces was quantified using in vivo zymography.

298 n causes endogenous agrin to localize to the cell surface, where it co-clusters with beta-dystroglyca

299 beyond regulating protein trafficking to the cell surface, whether and if so how these N-glycans cont

300 ss-of-function (LOF) mutations that increase cell surface Wnt receptor abundance cause sensitivity to