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1 nt with the notion that plant sanctioning is cell autonomous.
2 /fMx1-CreCbfb+/56M mice, and this effect was cell autonomous.
5 ered motor activity of dSod1 (G85R) We found cell-autonomous activation of bone morphogenetic protein
8 varied roles of Notch in cancer, focusing on cell autonomous activities that may be either oncogenic
10 es mammary tumorigenesis and metastasis, but cell-autonomous Akt2 deletion prevents breast cancer tum
11 hus, the germinal transcriptional program is cell autonomous and can proceed despite meiotic failure.
13 These 12-h rhythms of gene expression are cell autonomous and evolutionarily conserved in marine a
14 g astrocyte function, which could impact the cell autonomous and non-cell autonomous contribution of
15 rns of MAPK activity differentially regulate cell autonomous and non-cell autonomous effects of oncog
17 hanges across development, suggest that both cell autonomous and nonautonomous factors, and interacti
20 and development is determined by both cancer cell-autonomous and microenvironmental mechanisms, inclu
21 strate that MYC is coordinately regulated by cell-autonomous and microenvironmental signals, and esta
24 egulator during development, performing dual cell-autonomous and non-cell-autonomous functions.This a
25 ntrosome defects facilitate invasion through cell-autonomous and non-cell-autonomous mechanisms, sugg
26 nature, which were integrated to induce both cell-autonomous and non-cell-autonomous responses and tr
27 y manipulation in a tumor cell can have both cell-autonomous and nonautonomous effects and suggest th
29 test the hypothesis that BRD4 functions in a cell-autonomous and signal-responsive manner to control
30 gest that the balance between opposing tumor cell-autonomous and stromal effects may determine net ou
31 er identified profound discrepancies between cell-autonomous and systemic Akt1- or Akt2-inducible del
32 First, we analyse SCN timekeeping at the cell-autonomous and the circuit-based levels of organisa
33 vation showed a distinct profile between the cell-autonomous and the medium-transfer experiments.
34 y that the expression of CMF genes in ECs is cell-autonomous, and not simply a result of technical co
35 uivocal marker of autophagy, that promotes a cell-autonomous antiviral response that arose before evo
37 -null mice from HFD-induced diabetes is beta-cell autonomous, as beta cell-specific Galpha(z)-null mi
38 a suggest that the model should also include cell-autonomous aspects, as well as the use of structura
39 in the absence of other cellular clocks, the cell-autonomous astrocytic TTFL alone can drive molecula
41 This effect appears, at least in part, to be cell autonomous because enhanced osteoclastogenesis was
43 umor progression to metastasis is not cancer cell autonomous, but rather involves the interplay of mu
45 ial stem or progenitor cells whereas stromal cell-autonomous canonical Wnt/beta-catenin signaling ind
53 eep-wake and feeding-fasting, are coupled to cell-autonomous circadian clocks to synchronize organism
54 itical nodal element for keeping sustainable cell-autonomous circadian oscillation and reveals the ex
58 here that this mechanism is mediated not via cell-autonomous clock properties, but rather through alt
61 interactions versus transcriptionally driven cell-autonomous clocks in the timing of organismal bioen
62 intersectional genetic manipulations of the cell-autonomous clockwork can be used to determine how S
66 ich could impact the cell autonomous and non-cell autonomous contribution of astrocytes to neurodegen
67 cking, and has been previously linked to non-cell autonomous control of tumor growth and metastasis,
69 curs during male sexual maturation under the cell-autonomous control of the sex-determination pathway
71 re was no effect of IL-1R2 deficiency on the cell-autonomous cytokine response to IL-1beta in the tes
74 amination reveals that SAM loss results in a cell-autonomous defect in the proliferative expansion of
76 stimulation of innate immune receptors and a cell-autonomous defense mechanism that restricts the rep
77 terogeneity in the innate immune response to cell-autonomous degeneration within the central nervous
78 ring pancreas development, which restrains a cell-autonomous deleterious transcriptional program and
79 s become evident that tumorigenesis is not a cell autonomous disease, and an inflammatory microenviro
83 neurodegenerative diseases, including a non-cell autonomous effect on motor neuron survival in ALS.
88 st-traumatic OA, and also suggest intrinsic, cell-autonomous effects of IKKalpha in chondrocytes that
89 e activation of RTN neurons by CO(2)in vivo: cell-autonomous effects of protons; paracrine effects of
91 he therapeutic mechanisms operate via tumour-cell-autonomous effects on flux through one-carbon metab
95 s outlined how small incremental steps power cell-autonomous epithelial shape changes(1-3), which sug
96 her with beta-catenin signaling, resulted in cell-autonomous EPO transcription in mouse and human hep
97 e and validate a conditional mouse model for cell-autonomous expression of galactocerebrosidase (GALC
98 IST and the first in vivo demonstration that cell-autonomous expression of mutant KIT in the ICC line
101 local metabolism, however, its capacity for cell-autonomous expression of uncoupling protein 1 (UCP1
102 n in hepatic insulin resistance and that non-cell-autonomous factors contribute to FoxO1-dependent ef
103 ns of aging, selective vulnerability and non-cell-autonomous factors such as alpha-synuclein cell-to-
105 signaling promotes B lymphopoiesis in a non-cell-autonomous fashion in vitro, and depletion of the H
107 ts the maturation of their connectivity in a cell-autonomous fashion, both in vitro and in vivo, and
112 irradiation in a previously unreported non--cell-autonomous fashion; in addition, Crb1 delays UV and
113 scence-associated stemness is an unexpected, cell-autonomous feature that exerts its detrimental, hig
114 signaling while simultaneously inducing the cell-autonomous Fgf signaling inhibitor Dusp4 within the
117 Moreover, we reveal a lung cancer epithelial cell-autonomous function for p38alpha promoting the expr
121 s develop in the absence of T and suggests a cell-autonomous function of T as a gatekeeper between pa
122 gap junction molecule, which is regulated by cell-autonomous function of the worm homologs of a NMDAR
123 Using photoactivable Rac1, we demonstrate cell-autonomous functioning of invasive structures in pi
124 ent, performing dual cell-autonomous and non-cell-autonomous functions.This article has an associated
126 generation begs the question of whether stem cell-autonomous genomic architecture or environmental cu
127 ated radiotherapy is 65%, dependent on tumor cell-autonomous gradual buildup of DNA double-strand bre
129 e-dependent LC3B lipidation that may mediate cell-autonomous host defense, an unanticipated mechanism
130 lity of differentiated cells resulted in non-cell-autonomous hyperproliferation of stem cells and pre
131 ient viral cap snatching and regulation of a cell autonomous immune response, and provides synergisti
133 ed how the Toxoplasma effector GRA15 affects cell-autonomous immunity in human and murine cells.
135 tophagy are evolutionarily conserved arms of cell-autonomous immunity that restrict replication of in
136 ARPi, including olaparib and rucaparib, have cell-autonomous immunomodulatory properties in ERCC1-def
137 how that TDP-43-deleted astrocytes exhibit a cell-autonomous increase in GFAP immunoreactivity withou
138 state with a higher proliferative potential, cell-autonomous inflammation is an important contributor
141 conceptual advances in our understanding of cell autonomous innate immune responses against bacteria
142 tent stem cell yield depend on the extent of cell-autonomous innate immune activation and NO generati
144 We have previously shown that activation of cell-autonomous innate immune signaling facilitates the
148 ic seeding, suggesting that Rab27a may alter cell-autonomous invasive properties of the tumor cells.
151 AX2 1-LIKE3 (SMXL3), SMXL4, and SMXL5 act as cell-autonomous key regulators of phloem formation in Ar
154 or embryonic cortical neurogenesis and novel cell-autonomous Lgl1 functions controlling RGP-mediated
155 se results uncover a previously unrecognized cell-autonomous, light-sensing mechanism in brown adipoc
156 the nature and extent of EPF peptides as non-cell autonomous local signals and provide a means for qu
159 euroblast are very precisely controlled in a cell autonomous manner, after quiescence extrinsic facto
165 -type PNs influence CGE-derived INs in a non-cell-autonomous manner during cortical development.
166 rdium thickening were also impaired in a non-cell-autonomous manner in the Sox17 mutant, likely as a
167 n of adult neural stem/progenitor cells in a cell-autonomous manner in vitro and migration of their p
168 B cell leukemia/lymphoma 6 (BCL6) acts in a cell-autonomous manner to regulate the commitment but no
169 n neurons from neural stem cells (NSCs) in a cell-autonomous manner, altering postnatal cortical lami
170 gc1a(f/+)Alb-cre(+/0) mice of each sex, in a cell-autonomous manner, but was greater in livers from t
183 addition, SIX1 can induce metastasis via non-cell autonomous means, including activation of GLI-signa
184 r-associated fibroblasts, representing a non-cell autonomous mechanism for colon cancer progression.
185 SIGNIFICANCE STATEMENT We report a novel non-cell-autonomous mechanism regulating cell signaling in d
187 urons and in neural networks and occurs by a cell-autonomous mechanism that does not require network
194 that motoneuron properties do not mature by cell autonomous mechanisms alone, but also depend on dev
197 0) contribute to ferroptosis sensitivity, no cell-autonomous mechanisms have been identified that acc
198 choline, and histamine receptors, suggesting cell-autonomous mechanisms independent of synaptic trans
201 circuit stability is controlled both through cell-autonomous mechanisms that regulate some aspects of
202 ate invasion through cell-autonomous and non-cell-autonomous mechanisms, suggesting cancer cells can
205 reasing recognition of the importance of non-cell autonomous-mediated neurotoxicity, it is critical t
206 CYR61, a known secreted YAP target, is a non-cell autonomous mediator of cell survival, while another
208 ding of acetate metabolism in the context of cell-autonomous metabolic regulation, cell-cell interact
209 er involution in HD is thus a product of the cell-autonomous, mHTT-dependent suppression of glial dif
210 Overall, our study defines an FMRP-dependent cell-autonomous miR pathway that selectively alters deve
211 ficantly overlap those of BP, implying a non-cell autonomous mode of meristem control via one or more
212 distributions could not be fit by any simple cell-autonomous model of growth arrest, yet were easily
213 Together these studies begin to reveal how cell autonomous modulation of apoptosis in vascular cell
216 m KP activation but paradoxically suppressed cell-autonomous NAD(+) synthesis by limiting the convers
219 retion in the HD brains, contributing to non-cell-autonomous neurotoxicity in HD.SIGNIFICANCE STATEME
221 somes of eukaryotic cells, thereby providing cell-autonomous nutrients and removing harmful cargos.
222 size control in normal tissues, than to any cell-autonomous, 'oncogene-induced' program of senescenc
224 innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune
227 t the concept that IPF fibroblasts acquire a cell-autonomous pathological phenotype early in their di
228 of maturation of BM-derived LSECs is due to cell autonomous pathways that inhibit the nitric oxide p
229 bolism, which is driven by oncogene-mediated cell-autonomous pathways, the unique physiology of the t
230 rcadian rhythmicity is an approximately 24-h cell-autonomous period driven by transcription-translati
231 aft (PDX) cells, ultimately resulting in non-cell-autonomous PIM1 upregulation by endogenous IL7.
232 The differentiation of the medulla is a cell-autonomous process based on chromosomal sex identit
233 gress to melanoma, is widely attributed to a cell-autonomous process of 'oncogene-induced senescence'
234 erative diseases is hypothesized to be a non-cell-autonomous process that may be mediated by the prod
236 lism in cancer cells is regulated by diverse cell-autonomous processes, including signal transduction
239 FGF19 triggers a previously unsuspected, non-cell-autonomous program to activate STAT3 signalling in
240 ological SCA13(R420H) mutation, resulting in cell-autonomous progressive PC degeneration linked to ce
242 e found that Hippo disruption did not induce cell-autonomous proliferation but primed acinar cells to
243 estigated the mechanisms underlying this non-cell-autonomous protective signaling in the inner ear.
246 expression of pleiotrophin (PTN) and require cell-autonomous PTN signaling for CML pathogenesis in BC
247 evelopment in BCR/ABL+ mice, suggesting that cell-autonomous PTN signaling was necessary for CML dise
250 lin- and glucagon-positive cells through non-cell-autonomous regulation of ECM-integrin interactions
253 gest the critical function of TBK1 as a beta-cell autonomous replication barrier and present PIAA as
255 n of a Cre-expression construct identified a cell-autonomous requirement for paxillin in migrating ne
256 The CNS myelination defect results from a cell-autonomous requirement for THAP1 in the OL lineage
257 CreERT2, to demonstrate a mammary epithelial cell-autonomous requirement of CBL and CBL-B in the main
258 autonomous roles in cell flattening from non-cell-autonomous requirements for MTs in regulating proli
260 rated to induce both cell-autonomous and non-cell-autonomous responses and transcriptional plasticity
261 gnals controlling deployment of constitutive cell-autonomous responses during infection have remained
262 tive CD4(+) T cells lacking Nod2 reveals a T cell-autonomous, Rip2-independent mechanism for Nod2 in
264 rther analysis of this mouse model reveals a cell autonomous role for GALC in the development and mat
265 late demonstrating a previously undocumented cell autonomous role for GPI biosynthesis in NCC develop
266 e spermatid-related phenotypes, suggesting a cell autonomous role for MAFR-1 in nematode male fertili
267 edifferentiation suggesting a continuous and cell autonomous role for TGFbeta signaling in cell fate
268 Further, we find that beta-catenin has a cell autonomous role in the development of a medullary s
270 sis in the APC model of CRC, demonstrating a cell-autonomous role for IL-1 signaling in early tumor s
272 al KO mice from both sexes, we demonstrate a cell-autonomous role for SR in regulating synaptic NMDAR
276 a reveal a previously unappreciated critical cell-autonomous role of TNF on monocytes for their survi
281 opathies and nerve injuries and occurs via a cell autonomous self-destruction pathway whose mechanism
284 ur findings provide further insight into the cell-autonomous signals in post-pregnancy MECs that unde
285 ed fibroblasts (CAFs) cooperates with cancer cell-autonomous signals to increase MYC level, promoter
287 r, our results reveal the existence of a non-cell-autonomous "Stentian" signal, engaged by activation
288 ng mutation, self-reactive B cells exhibit a cell-autonomous subversion of their response to self-ant
292 We conclude that glucocorticoids restrain cell-autonomous TGFbeta signaling in ASCs to facilitate
293 enetic manipulations have been used to probe cell-autonomous timing in the SCN, identifying the integ
297 l functions of p75 in geniculate neurons are cell autonomous, we deleted p75 specifically in Phox2b +
298 ine activity of secreted WNT4, we identified cell-autonomous Wnt signaling activation by WNT4 and WNT