ライフサイエンスコーパス: cell-matrix adhesion

1 tations in EXPH5 have significant defects in cell-matrix adhesion.

2 potentiating schwannoma's proliferation and cell-matrix adhesion.

3 1, which is required for matrix assembly and cell-matrix adhesion.

4 emble podosomes, a specialized structure for cell-matrix adhesion.

5 ing to the relative strength of cell-cell to cell-matrix adhesion.

6 I and their different roles in cell-cell and cell-matrix adhesion.

7 the trafficking machinery, and cell-cell and cell-matrix adhesion.

8 ls also showed defects in both cell-cell and cell-matrix adhesion.

9 ion and development as well as cell-cell and cell-matrix adhesion.

10 rane-anchored HB-EGF increases cell-cell and cell-matrix adhesion.

11 tion are frequently generated in response to cell-matrix adhesion.

12 ssion inhibits beta1-integrin expression and cell-matrix adhesion.

13 ollagen appears to play an important role in cell-matrix adhesion.

14 orient polarity in response to cell-cell and cell-matrix adhesion.

15 -Smad signaling independently of its role in cell-matrix adhesion.

16 l reorganization in response to cell-cell or cell-matrix adhesion.

17 keletal organization, cell-cell contact, and cell-matrix adhesion.

18 r) cooperates with Integrin-beta1 to promote cell-matrix adhesion.

19 toskeletal tension, as well as cell-cell and cell-matrix adhesion.

20 s released upon removal of miR-29 to improve cell-matrix adhesion.

21 ular development, specifically by regulating cell-matrix adhesion.

22 al rearrangements required for cell-cell and cell-matrix adhesion.

23 enes implicated in networks of cell-cell and cell-matrix adhesion.

24 close to genes involved in intercellular and cell-matrix adhesion.

25 bited IEC migration while promoting enhanced cell-matrix adhesion.

26 vity, we were able to manipulate pre-cardiac cell-matrix adhesion.

27 tin cytoskeleton to facilitate cell-cell and cell-matrix adhesion.

28 hat plays a major role in integrin-dependent cell-matrix adhesion.

29 sions and that they are the modular units of cell matrix adhesions.

30 recruited and/or activated in cell-cell and cell-matrix adhesions.

31 M-1) at cell-cell junctions and integrins at cell-matrix adhesions.

32 activated and associates with cell-cell and cell-matrix adhesions.

33 1 is an important regulator of cell-cell and cell-matrix adhesions.

34 antioxidant, it has been reported to affect cell-matrix adhesions.

35 the role of protein-tyrosine phosphatases in cell-matrix adhesions.

36 y, migfilin facilitates VASP localization to cell-matrix adhesions.

37 ells, and in the latter, they co-localize in cell-matrix adhesions.

38 PIPkin or integrins and F-actin at sites of cell-matrix adhesions.

39 ith the conversion of cell-cell adhesions to cell-matrix adhesions.

40 refore functions as an important scaffold at cell-matrix adhesions.

41 s that are thought to dissolve cell-cell and cell-matrix adhesions.

42 horylation to generate two distinct types of cell-matrix adhesions.

43 cell migration via unique crosstalk between cell-matrix adhesions.

44 esent in cell-cell adhesions and absent from cell-matrix adhesions.

45 ng crosstalk between cell-cell junctions and cell-matrix adhesions.

46 and functions of intercellular junctions and cell-matrix adhesions.

47 n mechanosensing, through both cell-cell and cell-matrix adhesions.

48 g protein thought to reinforce cell-cell and cell-matrix adhesions.

49 d probe its mechanical properties by forming cell-matrix adhesions.

50 , and both have been shown to signal through cell-matrix adhesions.

51 s underlies the architecture and function of cell-matrix adhesions.

52 their microenvironment through cell-cell and cell-matrix adhesions.

53 phosphorylated at Y822 in cell-cell, but not cell-matrix, adhesions.

54 nce the actin cytoskeleton and cell-cell and cell-matrix adhesion all participate in the regulation o

55 ha subunits and participate in cell-cell and cell-matrix adhesion, all with important implications fo

56 g the effects of both cell-cell adhesion and cell-matrix adhesion, along with cell growth and proteol

57 lts suggest that there is cross talk between cell matrix adhesion and growth factors in the regulatio

58 mount for dynamic cellular functions such as cell matrix adhesion and mechanotransduction.

59 ilin and filamin define a connection between cell matrix adhesions and the actin cytoskeleton and par

60 ex process that is coordinately regulated by cell-matrix adhesion and actin cytoskeleton.

61 gh a cell required coordinated modulation of cell-matrix adhesion and actomyosin contractility in the

62 ion receptors such as integrins that mediate cell-matrix adhesion and also transduce signals into cel

63 ne alpha2 chains and plays a crucial role in cell-matrix adhesion and cell differentiation.

64 leukocyte processes and negatively enriched cell-matrix adhesion and cell junction assembly with LPS

65 the soluble Jagged1 protein caused decreased cell-matrix adhesion and cell migration defects.

66 modulation of AFAP-110 resulted in decreased cell-matrix adhesion and cell migration, defective focal

67 m1 and that the PDZ domain has a function in cell-matrix adhesion and cell migration.

68 f galectin-3 expression, resulted in reduced cell-matrix adhesion and cell migration.

69 This proposes that integrin-dependent cell-matrix adhesion and cell spreading are independentl

70 e, including small proteoglycans involved in cell-matrix adhesion and collagen fibrillogenesis.

71 t the expression of proteins associated with cell-matrix adhesion and cytoskeletal tension is regulat

72 ls, resulting in increased cell motility and cell-matrix adhesion and decreased cell-cell adhesion an

73 IP6K2 acts by enhancing cell-matrix adhesion and decreasing cell-cell adhesion.

74 Notch inhibited cells demonstrated decreased cell-matrix adhesion and enhanced lamellipodia formation

75 Reversible modulation of integrin-regulated cell-matrix adhesion and epithelial (E)-cadherin-mediate

76 We were also able to selectively restore cell-matrix adhesion and heart progenitor induction thro

77 hese data suggest that the interplay between cell-matrix adhesion and intercellular adhesion is an im

78 le 1 (ICAM-1), which is key to cell-cell and cell-matrix adhesion and leukocyte infiltration.

79 L), polymerizes actin at FAs, which promotes cell-matrix adhesion and mechanosensing.

80 ranching that occur during oncogenesis alter cell-matrix adhesion and migration by modulating integri

81 nificance of this, demonstrating that cancer cell-matrix adhesion and outgrowth were markedly inhibit

82 in D1 and FAK, leading to enhanced survival, cell-matrix adhesion and proliferation of schwannoma.

83 lacking p38delta also displayed an increased cell-matrix adhesion and reduced cell detachment.

84 asingly important role for integrin-mediated cell-matrix adhesion and signaling in endothelial barrie

85 udies revealed that JAM1 knockdown decreased cell-matrix adhesion and spreading on matrix proteins th

86 t Gas6 is mitogenic and increases schwannoma cell-matrix adhesion and survival acting via Axl in schw

87 P(C) contributes to increased proliferation, cell-matrix adhesion and survival in schwannoma cells ac

88 in the cellular control of integrin-mediated cell-matrix adhesion and that loss of this interaction l

89 LC-gamma1 to the plasma membrane at sites of cell-matrix adhesion and there promoting its enzymatic a

90 nd the actin cytoskeleton to cross talk with cell-matrix adhesion and thereby define a novel pathway

91 Integrins regulate cell-cell and cell-matrix adhesion and thereby play critical roles in

92 ests the mechanism by which maspin regulates cell-matrix adhesion and tumor cell invasion does not in

93 nal antagonism between Ddr/Intbeta1-mediated cell-matrix adhesion and Vegfr signaling appears to modu

94 s driven by an overall combination of strong cell-matrix adhesion and weak cell-cell adhesion by peri

95 Specifically, for sufficiently strong cell-matrix adhesion and/or sufficiently weak cell-cell

96 ced and confinement-induced EMT work through cell-matrix adhesions and cytoskeletal polarization, res

97 s suggest TRPV4 activity regulates forces at cell-matrix adhesions and is critical to aligned collage

98 spatiotemporally regulates the formation of cell-matrix adhesions and membrane protrusions through t

99 which affects talin and vinculin dynamics in cell-matrix adhesions and results in the formation of ta

100 to induce the formation of integrin-mediated cell-matrix adhesions and the signaling for cytoskeleon

101 l surface cell sheet characterized by strong cell-matrix adhesions and weak cell-cell adhesions.

102 kinase activity is required for turnover of cell-matrix adhesions and, in particular, the Src-depend

103 terize cell and matrix properties, including cell/matrix adhesion and mechanical and steric propertie

104 small GTPase regulating cell-cell adhesion, cell-matrix adhesion, and actin rearrangements, all proc

105 ch play critical roles in matrix deposition, cell-matrix adhesion, and actin stress fibers.

106 a key role in actin lamellipodia induction, cell-matrix adhesion, and cell anoikis.

107 ar reactive oxygen species (ROS) production, cell-matrix adhesion, and cellular protrusions at the le

108 lating cells, eventual loss of cell-cell and cell-matrix adhesion, and dose-dependent failure of blas

109 kin architecture, keratinocyte cell-cell and cell-matrix adhesion, and inflammatory skin responses.

110 o increased integrin-linked kinase activity, cell-matrix adhesion, and invasion through the extracell

111 erential distributions of protrusive forces, cell-matrix adhesion, and myosin-based retraction forces

112 Reversible modulation of cell-cell adhesion, cell-matrix adhesion, and proteolytic activity plays a c

113 pled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migrati

114 Integrins are components of cell-matrix adhesions, and function as scaffolds for var

115 Cell-cell and cell-matrix adhesion are crucial during many stages of e

116 s that regulate alterations in cell-cell and cell-matrix adhesion are deregulated to promote the earl

117 derlying schwannomas basal proliferation and cell-matrix adhesion are not understood.

118 nery to promote cell edge protrusions during cell-matrix adhesion are unclear.

119 is a novel mechanism by which cell-cell and cell-matrix adhesions are coordinated.

120 In animals, cell-matrix adhesions are essential for cell migration,

121 Cell-matrix adhesions are exquisite sensors of physiolog

122 Both cell-cell and cell-matrix adhesions are regulated by mechanical signal

123 sion in the cleft region and increased cleft cell-matrix adhesions are required for cleft progression

124 al tumors where alterations in cell/cell and cell/matrix adhesion are early steps in tumor disseminat

125 ing metastasis by facilitating cell-cell and cell-matrix adhesion as well as anchorage-independent ce

126 dy, we determine that CD82 expression alters cell-matrix adhesion, as well as integrin surface expres

127 ilin, a LIM-containing protein, localizes to cell-matrix adhesions, associates with actin filaments,

128 acoustofluidic device for parallel profiling cell-matrix adhesion at single-cell level.

129 sembly of epithelial cell-cell junctions and cell-matrix adhesions at the rear of migrating cells.

130 and intercellular stresses that tend to pull cell-matrix adhesions away from the boundary.

131 rowth factor receptor and ErbB2/3, increased cell-matrix adhesion because of the overexpression of in

132 The cell-matrix adhesion between podocytes and the glomerula

133 Targeted disruption of pre-cardiac cell-matrix adhesion blocked heart progenitor induction.

134 null mutants showed defective cell-cell and cell-matrix adhesion, both of which have been shown to p

135 During cell-matrix adhesion, both tyrosine and serine/threonine

136 version of epithelial cell-cell adhesions to cell-matrix adhesions, but the mechanisms of cleft forma

137 TGFbeta promotes cell-matrix adhesion by inducing the synthesis of extrac

138 r distinction between cell-cell adhesion and cell-matrix adhesion by showing that type IV collagen is

139 lobal regulator of endothelial cell-cell and cell-matrix adhesions, CD151 is needed for the optimal f

140 gical functions, such as cell-cell adhesion, cell-matrix adhesion, cell proliferation, motility and d

141 anize the ECM and regulate its engagement by cell-matrix adhesion complexes (CMACs) are therefore ess

142 Cell-matrix adhesion complexes (CMACs) play fundamental

143 n overview of the composition of endothelial cell-matrix adhesion complexes and associated signaling

144 Because signaling from cell-cell and cell-matrix adhesion complexes regulates cell proliferat

145 cytolinkers and components of cell-cell and cell-matrix adhesion complexes, i.e., desmosomes and hem

146 RAP1 activation is required for cell-matrix adhesion confirmed by adhesion to fibronecti

147 co-clustering of beta1 integrins and tTG at cell-matrix adhesion contacts.

148 ted cell-cell adhesion and integrin-mediated cell-matrix adhesion coordinate to affect the physical a

149 a, depression and schizophrenia, its role in cell-matrix adhesion could have implications for neural

150 Many of these are involved in cell-matrix adhesions, cytoskeleton, and transcriptional

151 ation of growth factor signaling facilitates cell-matrix adhesion disassembly via a phosphoinositide

152 , and genetic alterations that perturb local cell-matrix adhesion drove cell translocation.

153 n unexpected role of a classical cadherin in cell-matrix adhesion during cell migration.

154 tempers evoked Ca(2+) signals, and regulates cell-matrix adhesion during migration.

155 tion of the extracellular matrix and dynamic cell-matrix adhesion during reepithelialization.

156 ocess dependent on dynamic turnover of focal cell-matrix adhesions (FAs).

157 loss, namely multipolar morphology, enhanced cell-matrix adhesion, focal adhesion and, most important

158 d cells, which required B1-integrin-mediated cell-matrix adhesion for successful budding.

159 f both lamellipodium/invadopodia and nascent cell-matrix adhesions for directional migration and tumo

160 s suggest that LOX facilitates migration and cell-matrix adhesion formation in invasive breast cancer

161 OX regulates in vitro motility/migration and cell-matrix adhesion formation.

162 somes represent a class of integrin-mediated cell-matrix adhesions formed by migrating and matrix-deg

163 nal changes in extracellular compartment and cell-matrix adhesion genes but not in cell-cell adhesion

164 h these diverse functions different types of cell-matrix adhesions have been described.

165 al protein and plays a critical role in cell-cell matrix adhesion in the skin; however, its other bio

166 or cell surface adhesion receptors mediating cell-matrix adhesion in animals.

167 Given the importance of integrin-mediated cell-matrix adhesion in development of multicellular ani

168 phogenesis, which supports the importance of cell-matrix adhesion in driving branching morphogenesis.

169 Our results show that a spondin maintains cell-matrix adhesion in multiple tissues.

170 ecouple the effects of cell-cell contact and cell-matrix adhesion in TGFbeta1-induced EMT.

171 iple function of lamellipodia is to organize cell-matrix adhesions in a spatially coherent manner.

172 f the alpha2beta1 integrin from cell-cell to cell-matrix adhesions in breast epithelial cells.

173 her present recent insights into the role of cell-matrix adhesions in the developing and mature/adult

174 Here we report a novel role for 5-HT(2A) in cell-matrix adhesion.In HEK293 cells, which are loosely

175 n was not required for vinculin functions in cell-matrix adhesions, including integrin-induced cell s

176 nd glycoproteins implicated in cell-cell and cell-matrix adhesion interactions, cell migration, and t

177 e regulation of the F-actin cytoskeleton and cell-matrix adhesions, involve previously unrecognized c

178 ant model shows that integrin beta1-mediated cell-matrix adhesion is a major determinant of the mural

179 odel of cancer invasion, where cell-cell and cell-matrix adhesion is accounted for through non-local

180 Weakening of cell-matrix adhesion is blocked significantly (p < 0.01)

181 Cell-matrix adhesion is essential for building animals,

182 Cell-matrix adhesion is essential for the development an

183 Profiling the kinetics of cell-matrix adhesion is of great importance to understan

184 Loss of cell-matrix adhesion is often associated with acute epit

185 many mammalian cell types, integrin-mediated cell-matrix adhesion is required for the G1-S transition

186 migfilin, a recently identified component of cell-matrix adhesions, is a biphasic regulator of cell m

187 oA acts on both actomyosin contractility and cell-matrix adhesion, it suggests a role for such proces

188 zed that LPS increases integrin function and cell-matrix adhesion, leading to impaired enterocyte mig

189 vidence that a balance between cell-cell and cell-matrix adhesion may be critical for the normal deve

190 we focus on how understanding of endothelial cell-matrix adhesion may provide novel targets for treat

191 he effects of increased beta1,6 branching on cell-matrix adhesion-mediated phenotypes, human fibrosar

192 ated that these compounds strongly inhibited cell-matrix adhesion, migration, and invasion of U87-MG

193 the first direct evidence that BP180, a cell-cell matrix adhesion molecule, possesses antitumor funct

194 d in basal keratinocytes, and functions as a cell-matrix adhesion molecule in the dermal-epidermal ju

195 Mechanistically, the tension sensing cell-matrix adhesion molecule, vinculin, and the Rho/ROC

196 IP can function as a HP/HS-binding cell-cell/cell-matrix adhesion molecule.

197 ve survey of the complement of cell-cell and cell-matrix adhesion molecules in this organism.

198 erization triggered by specific cell-cell or cell-matrix adhesion molecules propelled invasive cell m

199 otein family serves to connect cell-cell and cell-matrix adhesion molecules to the intermediate filam

200 ted proteolytic activity, cell signaling, or cell-matrix adhesion necessary for cell migration during

201 utants, we establish which components of the cell-matrix adhesion network are coordinated through dir

202 Examples include cell-cell and cell-matrix adhesions, nucleoprotein bodies, and cell si

203 in this setting by modulating cell-cell and cell-matrix adhesion of endothelial cells.

204 (P10-P5', amino acids 330-345) alone induced cell-matrix adhesion of mammary carcinoma cells and corn

205 by the MEK1/ERK module promotes and sustains cell-matrix adhesion of untransformed cells.

206 ion, actomyosin contractility, cell-cell and cell-matrix adhesions on cleft progression, and it was u

207 vealed that fibrillar fibronectin can induce cell-matrix adhesions on cultured human salivary epithel

208 Although many cells generally require cell-matrix adhesion, our results demonstrate that CRKL

209 barrier dysfunction and suggest that common cell-matrix-adhesion pathways are involved in the progre

210 hereby KiSS-1 regulates events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reo

211 Cell-cell and cell-matrix adhesions play essential roles in the functi

212 Integrin-mediated cell-matrix adhesion plays an important role in control

213 velopment is the regulation of cell-cell and cell-matrix adhesion programmes.

214 n MIG-2-null colon cancer cells strengthened cell-matrix adhesion, promoted focal adhesion formation,

215 n that mutant FGFR3 alters the cell-cell and cell-matrix adhesion properties of urothelial cells, res

216 Migfilin interacts with the cell-matrix adhesion protein Mig-2 (mitogen inducible ge

217 gulation of genes encoding for cell-cell and cell-matrix adhesion proteins, and in the upregulation o

218 reflect the traditional view of integrins as cell-matrix adhesion proteins.

219 cells of the blistered skin, suggesting that cell-matrix adhesion provided by laminin 5 plays a role

220 dation of the surrounding ECM accompanied by cell-matrix adhesion pulls the cells into the surroundin

221 An important role of cell matrix adhesion receptors is to mediate transmembra

222 ion of E-cadherin would affect expression of cell matrix adhesion receptors.

223 Integrins are cell-matrix adhesion receptors, and clustering of integr

224 s with increased expression of cell-cell and cell-matrix adhesion receptors.

225 Integrin-mediated cell-matrix adhesions regulate communication between cel

226 s how the dynamic regulation and turnover of cell-matrix adhesions regulates endothelial barrier func

227 , PCOLN3; the metalloprotease PRSM1; and the cell matrix-adhesion regulator, CMAR.

228 eves its distinct functions at cell-cell and cell-matrix adhesions remains unanswered.

229 Its function, other than cell-matrix adhesion, remains unclear.

230 ntrolled by signal-mediated cytoskeletal and cell matrix adhesion remodeling.

231 the placodes and senses the gradient through cell-matrix adhesions, resulting in polarized Rac activi

232 While increased mechanical loading at cell-matrix adhesions results in focal adhesion growth,

233 helial migration through activation of focal cell-matrix adhesion signaling in primary human intestin

234 TK) with key roles in integrating growth and cell matrix adhesion signals, and FAK is a major driver

235 composition of the extracellular matrix and cell-matrix adhesion sites provides cells with a means o

236 a1 integrin nor tensin localize to fibrillar cell-matrix adhesion sites.

237 critical for maintaining the composition of cell-matrix adhesion sites; in the absence of fibronecti

238 d locally, rapidly, and correctly as diverse cell-matrix adhesion sites?

239 analyses of cell motion, membrane dynamics, cell-matrix adhesion status and F-actin organization, th

240 strength, epithelial cell mitosis rate, and cell-matrix adhesion strength.

241 Cell-matrix adhesion strongly influences developmental s

242 Hemidesmosomes are specialized cell-matrix adhesion structures that are associated with

243 These findings, perturbed and up-regulated cell-matrix adhesion, suggest possible mechanisms for th

244 pe adhesion system (cadherin/nectin) and the cell-matrix adhesion system (integrin/CD155) by virtue o

245 somes and are thought to be more involved in cell-matrix adhesion than invadopodia [2-4].

246 Cooperative cell-cell and cell-matrix adhesions that sculpt the emerging tissue ar

247 Hemidesmosomes (HDs) are epithelial-specific cell-matrix adhesions that stably anchor the intracellul

248 nabled and enhanced by altered cell-cell and cell-matrix adhesion, the cancerous mass can invade the

249 anied by fibronectin deposition and stronger cell-matrix adhesion, the transition to leader-cell phen

250 estrating cytoskeletal tension and cell-cell/cell-matrix adhesion, therefore solidifying the importan

251 other matrices and integrins are involved in cell-matrix adhesion, this model system gives us a limit

252 reas activation of the IGF-IR kinase reduces cell-matrix adhesion through a PI-3K-dependent, but ROCK

253 blastin (Ambn) has the potential to regulate cell-matrix adhesion through familiar cell-binding domai

254 iate divalent cation-dependent cell-cell and cell-matrix adhesion through tightly regulated interacti

255 s are multifunctional organelles that couple cell-matrix adhesion to cytoskeletal force transmission

256 emodels the extracellular matrix and adjusts cell-matrix adhesion to guide the way.

257 action couples with actin polymerization and cell-matrix adhesion to regulate cell protrusions and re

258 in the cell assembly, which is controlled by cell-matrix adhesion to the adhesive micropattern.

259 mbrane skeleton and that links cell-cell and cell-matrix adhesion to the development of cell polarity

260 Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammator

261 These results indicate that the loss of cell matrix adhesion triggers protein kinase C activatio

262 own, although an alteration in cell-cell and cell-matrix adhesion versus an autoimmune process has be

263 We hypothesized that Dsg2 may mediate cell-matrix adhesion via control of Rap1 GTPase, which i

264 dings show that RAP1 has a prominent role in cell-matrix adhesion via extracellular matrix molecule f

265 hat Sdf1 and Sema3A antagonistically control cell-matrix adhesion via opposite effects on Rac1 activi

266 The impact of cAMP on cell-matrix adhesion was followed by immunostaining of f

267 When cell-matrix adhesion was reduced (in poly(2-hydroxyethyl

268 Both the increase and decrease in cell-matrix adhesion were blocked by disrupting intracel

269 Thus, we have characterized an endothelial cell matrix adhesion, which shows complex cytoskeletal i

270 tion of forces from intercellular tension to cell-matrix adhesions, which break down the cadherin jun

271 Mig-2 recruits migfilin to cell-matrix adhesions, while the interaction with filami

272 t low-dose, disrupts the integrity of TJ and cell-matrix adhesions, with indicators of cellular stres