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1 ross the Orthopneumovirus genus and not host-cell specific.
6 genetic, pharmacologic, RNAscope assay, and cell-specific ablation methods, we dissected a neural ci
9 erate with IL-25 to activate ILC2s, and tuft-cell-specific ablation of leukotriene synthesis attenuat
11 Rgamma reprogramming is altered in mice with cell-specific ablation of the dopamine D2 receptor (D2R)
13 nsition driver transcription factors in stem cell-specific accessible regions that become repressed i
14 or of cytokinesis 2 (DOCK2), a hematopoietic cell-specific actin effector protein, has been implicate
15 cs of the channelrhodopsin-2 (ChR2) used for cell-specific activation are too slow to follow the high
20 ation, and regulation apparently arises from cell-specific alternative splice variants of the single
22 r studies define the molecular mechanisms of cell-specific alternative splicing of a functionally val
24 Moreover, the finding that proximal tubule cell-specific amphiregulin knockout mice were protected
26 er, these data confirm that M2 function is B cell-specific and demonstrate that M2 primarily function
29 Relative to females, males had reduced B cell-specific and NK cell-specific transcripts and an in
31 ed Ag presentation to CD8 T cells, revealing cell-specific and temporal features involved in the gene
34 In this Review, we use a layer-specific and cell-specific approach to integrate physiological accoun
38 r, an animal model that could recapitulate T cell-specific autoimmune responses by initiating and sus
42 nk conditioning, and both global and granule-cell-specific CB1KOs display normal cerebellum-dependent
44 ng macrophage-specific (CD14) but not CD4+ T cell-specific (CD3) antibodies, suggesting that M-tropic
46 ovide new insight into the longevity of beta cell-specific CD8(+) T cell responses and document the u
48 ell 'multipotency index' and found that beta cell-specific CD8(+) T cells retained a stem-like epigen
50 pment with submission of 10,932 novel tissue/cell specific CDS to the NCBI database for this importan
53 transcription factor Foxp3 establishes Treg-cell-specific chromatin architecture indirectly, mostly
55 ms of Raf activation, and point to targeting cell-specific, chromatin-accessible, and parallel (or re
59 utational framework, can be used to discover cell-specific cofactors, screen for synthetic cooperativ
60 e-body miR-155 knockout mice and endothelial cell-specific conditional miR-155 (VEC-Cre-miR-155 or VE
64 Bmp1 and Tll1 genes in mice using a Schwann-cell-specific Cre causes ectopic clustering of nodal pro
66 d flow-induced vasodilatation in endothelial cell-specific CSE knockout mice and in a small collectiv
69 ulin into knockout mice with proximal tubule cell-specific deletion of amphiregulin's releasing enzym
71 n sharp contrast, mice harboring endothelial cell-specific deletion of IDO show an improvement of car
72 reover, bone marrow chimeric mice with CD4 T cell-specific deletion of IL-10 increased PF4/heparin-sp
73 TCR activation, as mice engineered with a T cell-specific deletion of IRAP fail to develop efficient
77 ed intestinal tissues from mice with myeloid cell-specific deletion of PTPN2 (Ptpn2-LysMCre mice) and
81 is independent of T-cell exhaustion, using B-cell-specific deletion of the transcription factor IRF4
82 ssing a point mutant thereof, or mice with T cell-specific deletion of the transcription factor RUNX1
85 stand their biology, but also may permit the cell-specific delivery of small molecules to improve the
86 idazolate frameworks (ZIFs) for targeted and cell-specific delivery of this genome editing machinery.
87 a1 integrin-blocking antibody or endothelial cell-specific depletion of beta1 integrin attenuated FMD
88 excitatory-inhibitory balance is dynamic and cell specific, determined by distinct plasticity rules a
90 nd validated Gal4-UAS based CRISPR tools for cell-specific disruption of key molecular clock componen
91 ows efficient analysis of aged and cancerous cell-specific DNA methylation patterns for diagnostic an
93 oid action and emphasize the multifactorial, cell-specific effects of these drugs, with potential imp
97 , using eFOV-microendoscopes we demonstrated cell-specific encoding of behavioral state-dependent inf
98 to open chromatin, and classify sets of stem cell-specific, endoderm-specific, and shared accessibili
99 with only 100% lithium excess can deliver a cell specific energy of >300 W h kg(-1) with a Coulombic
100 alyses showed that these five loci contained cell-specific enhancers that differed between normal lum
101 pecific phospholipase C gamma 2 (PLCG2), a B cell-specific enzyme that stimulates intracellular Ca(2+
104 from three C(4) grass species could drive M-cell-specific expression of a reporter gene in rice.
112 uitin ligase complex can recruit endothelial cell-specific factors, AGO2 (associated with angiogenesi
114 odds ratio (OR) = 58, P = 1 x 10(-75)) from cell-specific features, including chromatin conformation
115 (b) a cell-specific methanogenic activity to cell-specific fermentation activity ratio of >1000.
116 ) mice and in SIP cells from mice expressing cell-specific fluorescent reporters purified by fluoresc
117 tline an immunotherapy in which endogenous T cells specific for a noncancer antigen are retargeted to
120 he presence of a broad repertoire of naive T cells specific for cryptic H1-HA peptides and demonstrat
122 s a common feature of populations of naive B cells specific for foreign Ags and a moderate level of c
124 hese results show that self-HLA-restricted T cells specific for self-antigens such as MiHA in MiHApos
125 tionality throughout latency, while CD8(+) T cells specific for subdominant epitopes undergo function
126 ctively expand both low- and high-affinity B cells specific for the antigenic bait during immunizatio
128 ss-recognition of the novel coronavirus by T cells specific for the common cold coronaviruses.METHODS
129 In vitro expansion studies suggested that T cells specific for the HCoV-NL63 spike protein in this i
130 against the parasite is mediated by CD8(+) T cells specific for the immunodominant CSP-derived epitop
132 cle, we explore the contribution of CD8(+) T cells specific for the major antigenic epitope for HSV-1
134 ptide pools.CONCLUSIONHDs have circulating T cells specific for the spike proteins of HCoV-NL63, HCoV
135 interferon gamma (IFN-gamma)-producing CD4 T cells specific for VZV glycoprotein E and all other stru
136 ain-Containing Protein (FCHSD2) has a cancer-cell specific function in regulating CME in non-small-ce
138 n controversial, owing to differences in the cell-specific functions of AhR and the different activat
139 evidence to suggest that some expansins have cell-specific functions, in root hair and pollen tube de
141 cretion response of islets from HFD-fed beta cell-specific Galpha(z)-null mice is significantly impro
142 ed diabetes is beta-cell autonomous, as beta cell-specific Galpha(z)-null mice phenocopy the full-bod
144 Activation of beta-catenin-driven and stem cell-specific gene expression in the presence of Apc (Mi
145 d assess variability in cell composition and cell-specific gene expression in the skin of patients wi
147 ealth of information about the mechanisms of cell-specific gene expression, chromosome dynamics, prot
149 m multiplex families to identify significant cell-specific gene network alterations in SCZ, these stu
150 hts into relevance of noncoding variants for cell-specific gene regulation and for disease associatio
153 sociated genes as well as activation of hair cell-specific genes required for normal functional matur
154 nor zygotic genome activation (ZGA) genes (2-cell-specific genes) in pluripotent and differentiated c
161 ntification of gp120 glycopeptide-induced, T cell-specific immune responses offers a foundation for d
162 This CTLA-4-dependent inhibition was Tfh cell specific in that CTLA-4 expression by Tfh cells was
164 approach by first generating mice with beta-cell-specific inducible overexpression of Bmal1 (core ci
165 ating that the adopted technique can provide cell-specific information and knowledge, closely linked
171 irway cultures establish NEK10 as a ciliated-cell-specific kinase whose activity regulates the motile
174 al shRNA and conditional mutation to produce cell-specific knockdown or deletion of a key NMDAR subun
175 urther analysis of GABA subtypes showed that cell-specific knockdown or deletion of GluN2B in Sst int
177 ase was absent from PIs from NOX4-null, beta-cell-specific knockout mice (NOX4betaKO) (though not fro
178 es, as well as the elaborate conditional and cell-specific knockout mouse studies that brought the ro
183 the SSRI, fluoxetine, are abolished by mossy cell-specific knockout of p11 or Smarca3 or by an inhibi
184 s and showed that its elimination in myeloid cell-specific L13a knockout mice (L13a KO) increased ath
187 s a growing interest in molecular imaging of cell-specific lineage markers of the immune system using
189 very and functional elucidation of a human B cell-specific lncRNA with high levels of expression in t
196 o and alter the transcriptional program in a cell-specific manner in a mouse model of synpolydactyly.
197 e models targeting either whole ERalpha in a cell-specific manner or ERalpha subfunctions (membrane/e
198 etic protein can stimulate regeneration in a cell-specific manner, but also provide a blueprint of ho
199 nels and receptors occurs in a concerted and cell-specific manner, resulting in the appearance of bra
203 debCAM) that can automatically detect tissue/cell-specific markers, determine the number of constitue
205 n neurons and astrocytes further highlighted cell-specific mechanisms to counteract redox imbalance.
206 established as an inducible and mesenchymal cell-specific mediator of disease progression in cancer
208 gulates microglia polarization, we highlight cell-specific metabolome reprogramming as a promising no
209 fermentation ratio higher than 0.6 and (b) a cell-specific methanogenic activity to cell-specific fer
211 r distribution in wild-type and intercalated cell-specific mineralocorticoid receptor knockout mice.
215 -suppressive role of KDM6A deficiency with a cell-specific molecular mechanism that underlies PDAC su
216 type natriuretic peptide], ESM [endothelial cell-specific molecule]-1, cathepsin L1, osteopontin, an
218 , we identified a mechanism whereby opposing cell-specific motogenic functions of a multifunctional i
219 this, we first tested three inducible mural cell-specific mouse lines using a sensitive Ai14 reporte
221 e of an interaction network and/or selecting cell-specific networks has a limited effect on accuracy.
222 Our results advance our understanding of how cell-specific neurobiological gradients produce a hierar
229 udy common herpesvirus assembly pathways and cell-specific pathways for membrane reorganization.IMPOR
230 revious screens, we succeeded in finding new cell-specific patterns, which we validated by in situ an
233 gene is upstream of the gene encoding the B cell-specific phospholipase C gamma 2 (PLCG2), a B cell-
235 ometry to assess changes in BNST plasticity, cell-specific physiology, and cellular activity profiles
241 , 2020) reveal an essential function of germ cell-specific protein GCNA in the genome maintenance of
243 ction of viral load, while transcripts for B cell-specific proteins and neutrophil chemokines were el
244 anatomy-based approach, as the identities of cell-specific PSC molecular markers have remained elusiv
246 morphological changes were assessed in mural cell-specific R26-mTmG reporter mice, in which low doses
247 When sample preparation is accounted for, cell-specific rates increase and are more consistent wit
248 receptor X2 (MRGPRX2) is regarded as a mast cell-specific receptor mediating non-IgE-dependent activ
251 geted imaging mass spectrometry demonstrates cell-specific reduction of phospholipids containing 22:6
252 cell context-dependent effect resulted from cell-specific regulation of extracellular signal-regulat
254 ecific transcriptional regulators and infers cell-specific regulation of protein-coding genes, long i
255 of neuron-specific genes, that ASEs provide cell-specific regulatory information with evidence for c
256 s accompanied by the appearance of quiescent cell-specific repressors and rewiring of the interaction
257 ents demonstrate the in vivo sequelae of the cell-specific requirements for the functions of AK2 and
258 y AD, but suction blistering was superior in cell-specific resolution for high-abundance transcripts
259 al smoking response networks and hundreds of cell-specific response genes, redefining the penetrance
260 single-cell omics approaches to characterize cell-specific responses to drugs or environmental stimul
262 o promoted Cd40 mRNA association with Muller cell-specific ribosomes isolated from the retina of Ribo
263 ngle-cell RNA sequencing in combination with cell-specific Ribotag RNA profiling, assay for transposa
269 as, however, been limited due to the lack of cell-specific targeting methods in brain tissue or livin
270 is biomimetic approach to match the needs of cell-specific targeting, which is unquestionably the mos
275 very promises benefits in the form of single-cell-specific therapeutic and diagnostic capabilities.
279 cy of antiviral effector memory CD4(+) T(EM) cells specific to two immunodominant epitopes derived fr
280 splenic B cells purified from young adult B cell-specific Traf3 (-/-) and littermate control mice.
282 wever, the expression of Foxp3, regulatory T cell-specific transcription factor, was enhanced in the
283 lity that RNAPII pool size generally affects cell-specific transcription programs in genome instabili
284 ted as likely candidates for sustaining germ cell-specific transcription programs throughout the peri
287 nterpreters of the epigenome that facilitate cell-specific transcriptional programs and are therapeut
288 Transcription factor footprinting implicates cell-specific transcriptional regulators and infers cell
290 aenorhabditis elegans early embryos generate cell-specific transcriptomes despite lacking active tran
293 es, males had reduced B cell-specific and NK cell-specific transcripts and an increase in inhibitors
294 , we uncover new sets of female gametophytic cell-specific transcripts with predicted biological role
296 st marker genes TRAP, Cathepsin K, dendritic cell-specific transmembrane protein (DCSTAMP), nuclear f
298 nt cell lines on a global scale, but notable cell-specific variations emerge in the detailed spatial