ライフサイエンスコーパス: cellular effect

1 y these signaling factors wield such diverse cellular effects.

2 ide are important bioactive lipids with many cellular effects.

3 ethionine aminopeptidases (MetAPs) for their cellular effects.

4 of suppression of POX/PRODH in MYC-mediated cellular effects.

5 ders, suggesting that they may induce common cellular effects.

6 Inhibition of PI3K had similar adverse cellular effects.

7 ivities as well as those that impede optimal cellular effects.

8 PTX in vivo likely stem from their distinct cellular effects.

9 ccurring phytochemicals with weak estrogenic cellular effects.

10 ng oxidized lipoproteins and mediating their cellular effects.

11 N and Bcl-2 were involved in miR-21-mediated cellular effects.

12 means by which diverse stimuli mediate their cellular effects.

13 d through activation of PERK to induce their cellular effects.

14 is not known whether gJ mediates additional cellular effects.

15 and infected fibroblast monolayers to assess cellular effects.

16 causes the GC disruption, leading to various cellular effects.

17 nantiomer of D-e-Cer, failed to induce these cellular effects.

18 s interaction proved insufficient to mediate cellular effects.

19 tivation of protein kinases leads to diverse cellular effects.

20 PRA and PRB, respectively), each with unique cellular effects.

21 ately determines the extent of IGF-dependent cellular effects.

22 effects can produce significantly different cellular effects.

23 prime candidate for mediating some of Rac's cellular effects.

24 environmental industries to measure adverse cellular effects.

25 y downstream effector proteins to elicit its cellular effects.

26 to DNA damage, mutagenesis and other harmful cellular effects.

27 usions with similar morphology but different cellular effects.

28 on TGFbeta because of its known pleiotropic cellular effects.

29 n of alphaT3-1 cells indicating long-lasting cellular effects.

30 riptional regulation downstream of DEK1 with cellular effects.

31 s associated with WGD, focusing primarily on cellular effects.

32 nd the responses they elicit, may have broad cellular effects.

33 ulators RCC1 and RanGAP mediates many of its cellular effects.

34 nsic differences between fragments and their cellular effects.

35 n alter the presentation to target cells and cellular effects.

36 our metastasis suppressor which has multiple cellular effects.

37 KC isoforms alpha and beta mediate different cellular effects.

38 ich biological amphiphiles can produce their cellular effects.

39 Typically, the cellular effect accompanies an induction of mesodermal c

40 is cohort of perturbations, representing key cellular effects across sets of ASD/ND risk genes.

41 rming growth factor-beta (TGF-beta)-mediated cellular effects and examined the signaling pathway invo

42 ovide a mechanistic explanation for both the cellular effects and in vivo phenotypic abnormalities in

43 nterest to determine whether TC10 has unique cellular effects and interacts with the same targets as

44 ng has potential for elucidating the complex cellular effects and mechanisms of action of novel targe

45 In this study we examined the cellular effects and molecular mechanism of the arrestin

46 fine-tuners of a range of pathophysiological cellular effects and molecular signaling pathways involv

47 characteristics of mutant TDP-43 to aberrant cellular effects and patient phenotype.

48 pound induces characteristic LPA(1)-mediated cellular effects and prompts the internalization of the

49 uced calcium responses to mediate downstream cellular effects and providing evidence for TRPA1 functi

50 ated TLR3 can engage Src to trigger multiple cellular effects and reveal a possible link between inna

51 epidermis as a model system to elucidate the cellular effects and signaling feedback sequelae of mTOR

52 All these cellular effects appear to depend on the G-quadruplex bi

53 These cellular effects are accompanied by alterations of the a

54 This study suggests that some MYC-induced cellular effects are due to MYC regulation of proline me

55 These cellular effects are in line with the recently reported

56 interacting with a receptor whose downstream cellular effects are mediated by the cta G(alpha)protein

57 ich secretory phospholipase A2 (PLA2) exerts cellular effects are not fully understood.

58 ecretory phospholipases A(2) (PLA(2)s) exert cellular effects are not fully understood.

59 The DNA damage pathways underlying these cellular effects are not well understood.

60 ranslational regulation of HuR and resulting cellular effects are poorly understood.

61 We show that the first observable cellular effects are the formation of membrane distortio

62 s of growth/guidance stimulate such negative cellular effects as F-actin disassembly/repulsion.

63 rall structure of Vpr is essential for these cellular effects, as N- and C-terminal deletions affecte

64 At least 1 of the cellular effects associated with HIV inhibition is inter

65 enzyme and its human counterpart, and their cellular effects at different stages of the Trypanosoma

66 ranslational modification, with differential cellular effects based on phosphorylation at specific se

67 ta, and IFN-omega, induce somewhat different cellular effects but act through a common receptor compl

68 gy, similar gene sequence, and exert similar cellular effects, but the replication of the virus outsi

69 Progesterone can exert cellular effects by acting on membrane receptors or by a

70 rigenesis, is thought to mediate its diverse cellular effects by altering the expression of specific

71 , FGF21, and FGF23 mediate their pleiotropic cellular effects by binding to and activating binary com

72 It is thought that estrogen exerts its cellular effects by regulating the expression of specifi

73 60 nm, well below that of 5-15 microm, where cellular effects by sarcoplasmic/endoplasmic reticulum c

74 ctivity within seconds, indicating that some cellular effects can occur via membrane delimited events

75 ctivity within seconds, indicating that some cellular effects can occur via membrane delimited events

76 s how this new assay, targeted to downstream cellular effects, can uncover unique ligand efficacies l

77 coordinate responses to mitigate deleterious cellular effects caused by disrupted NPC assembly.

78 o its extracellular (EC) domain, whereas its cellular effects depend on activation of its cytoplasmic

79 Additional cellular effects due to inhibition of Aurora kinases inc

80 y characterising transcriptional changes and cellular effects following modulation of p63 expression,

81 ism, and immune response that could indicate cellular effects from HOC exposure.

82 PAHAs and PABAs exhibit strikingly different cellular effects from SAHA and have the potential for us

83 After documenting the in vitro cellular effects, halofuginone (intraperitoneum injectio

84 of membrane-associated AMPs as well as their cellular effects have been extensively documented; howev

85 wide variety of structural, functional, and cellular effects have been identified in reproductive tr

86 Individual Ox-PL responsible for specific cellular effects have been identified.

87 and extensive knowledge of its molecular and cellular effects, how anesthesia induces loss of conscio

88 Y-tissue staining, but also uncovering acute cellular effects in areas connected to the ischemic core

89 This unique combination of cellular effects in conjunction with acute channel block

90 these different mutations may have variable cellular effects in neurons and/or oligodendrocytes.

91 s mammalian erythropoiesis, exhibits diverse cellular effects in non-hematopoietic tissues.

92 anti-HIV microbicide application concerning cellular effects in rectal mucosa.

93 c patients and to functionally analyze their cellular effects in the mitochondrial compartment.

94 integrating and spatially restricting their cellular effects in time and space.

95 heterodimer with RXR, mediates a variety of cellular effects including adipocyte-differentiation.

96 -kinase/Akt/mTOR pathway causing pleiotropic cellular effects including an mTOR-dependent loss in ins

97 g AgNPs' main parameters that modulate their cellular effect, including size, shape, capping, and sur

98 mplex (GC), which is associated with various cellular effects, including anoikis.

99 ic subtypes of meningioma and exerts diverse cellular effects, including DR5 up-regulation, modulatio

100 active phospholipid, induces a wide range of cellular effects, including gene expression, cytoskeleta

101 th cytosolic RNA degradation and pleiotropic cellular effects, including growth inhibition and apopto

102 myelogenous leukemia (CML) and has multiple cellular effects, including the induction of autophagy a

103 We also demonstrate that these cellular effects, increased rate of oxidative metabolism

104 esting a link between biochemical events and cellular effects induced by CD38.

105 Amongst the cellular effects induced by cholinergic modulation are a

106 ule cells, the heterogeneous distribution of cellular effects induced by ectopic En expression sugges

107 and we have explored potential links between cellular effects induced by rapamycin and p53.

108 ise mechanism by which FGF19 regulates these cellular effects is poorly understood.

109 ription of genes involved in a wide range of cellular effects known to increase the aggressive nature

110 These cellular effects may predispose individuals with a histo

111 Among the multiple cellular effects mediated by lysophosphatidic acid (LPA)

112 n physiologically counteracts several of the cellular effects mediated by the activation of beta-adre

113 NAs in H(2)O(2)-mediated gene regulation and cellular effects, miR-21 expression was down-regulated b

114 O (a nitrosating agent) and NO have distinct cellular effects; NO more effectively interacts with glo

115 on regulator, itself is a growth factor with cellular effects not dependent on IGFs.

116 The first cellular effect observed with continuous exposure to 50

117 K inhibitors 8a and 8b that recapitulate the cellular effects observed by short hairpin ribonucleic a

118 However, none of the cellular effects observed using ICMT inhibitors were as

119 To determine the cellular effect of disrupting ERK5 signaling from CCR7,

120 We used 401 to test the cellular effect of mTOR inhibition without the complicat

121 in human ovarian carcinoma, we examined the cellular effect of oncogenic RAS on the expression statu

122 Thus, this cellular effect of PEP-19 does not depend simply on bind

123 cell technologies to identify a significant cellular effect of rare penetrant NRXN1 mutations in hum

124 SOCS-3 induction is the first cellular effect of resistin that is independent of insul

125 ding proteins whose occupancy determines the cellular effect of stimulation.

126 t this concentration could also abolish this cellular effect of TCDD.

127 A more detailed analysis of the cellular effect of these PI3K/mTOR dual inhibitors demon

128 The phase II Lessons From Antagonizing the Cellular Effect of Thrombin-Coronary Artery Disease (LAN

129 w data help resolve the roles of the diverse cellular effects of 2ME2 including microtubule disruptio

130 stic information that clarifies the multiple cellular effects of 2ME2, and the identification of prom

131 one gamma-H2AX by 4NQO may contribute to the cellular effects of 4NQO, including its selective activi

132 p a quantitative trait locus influencing the cellular effects of 5-fluorouracil to chromosome 9q13-q2

133 e pool of tagged heterozygotes to assess the cellular effects of 78 compounds in Saccharomyces cerevi

134 Cellular effects of a Nedd8-activating enzyme (NAE) inhi

135 work provides a greater understanding of the cellular effects of a non-JAK2V617F, MPN-associated JAK2

136 l of these cyclodepsipeptides, we probed the cellular effects of a novel and representative family me

137 eview summarizes recent studies highlighting cellular effects of adiponectin and its role in human li

138 ase, mechanisms underlying the molecular and cellular effects of alcohol, the application of new and

139 us reports that Golgi fragmentation mediates cellular effects of alphaSNAP knockdown, we found that e

140 Previous studies on the cellular effects of altered levels of two of these rRNAs

141 We show that these off-target cellular effects of AM251 are mediated by proteasomal de

142 Because little is known about the direct cellular effects of Ang II on human cardiac fibroblasts,

143 gned to the multidomain APC protein, but the cellular effects of APC expression and how they relate t

144 This study provides new perspectives on the cellular effects of APC that might lead to a deeper unde

145 ation R61T is able to rescue the deleterious cellular effects of ApoE4 by preventing the formation of

146 ity that this enzyme may mediate some of the cellular effects of araC.

147 Together, these results suggest that cellular effects of biguanides depend on their metal-bin

148 platforms provide functional information on cellular effects of bioactive or toxic compounds in a sa

149 We examined the detailed molecular and cellular effects of blockade of IL-17 signaling in human

150 ating evidence has demonstrated that the net cellular effects of cAMP are also regulated by EPAC.

151 Thus, we suggest that at least some of the cellular effects of carotenoids are mediated through the

152 In subsequent analyses of the cellular effects of CD56(140kD) overexpression in the de

153 chain ceramide analogs, widely used to study cellular effects of ceramide, have biological effects th

154 DNA lesions near a DSB and that the indirect cellular effects of cisplatin treatment are not signific

155 signaling is required for the behavioral and cellular effects of cocaine.

156 In contrast, the cellular effects of congener 21a, which inhibited Clk1 o

157 s suggest that stress-induced changes in the cellular effects of CRF in the DRN translate to changes

158 lity as antiparasitic agents, we compare the cellular effects of curcumin and the enone linker lead c

159 de serves as a second messenger in mediating cellular effects of cytokines and stress.

160 We further investigate the cellular effects of dasatinib and other comparable KIs w

161 These in vivo results demonstrate that the cellular effects of DNA damage depend on the development

162 two quantitative trait loci influencing the cellular effects of docetaxel to chromosomes 5q11-21 (LO

163 Although molecular and cellular effects of dopaminergic signalling have been ex

164 tatin 5 (1), which attenuated the downstream cellular effects of elastase in an epithelial lung airwa

165 In this study we addressed the molecular and cellular effects of elevated and suppressed levels of ci

166 d provide mechanistic insight into the rapid cellular effects of estrogen on brain function.

167 However, the subsequent cellular effects of Et743 are not fully understood.

168 stand the interrelationship of the different cellular effects of ExoS, functional analyses were perfo

169 tation appeared to have little impact on the cellular effects of ExoS.

170 heterotrimeric G proteins in modulating the cellular effects of extracellular nucleotides.

171 Although other cellular effects of EZH2 inhibition may contribute to th

172 Herein, we focus on the cellular effects of G(o) signaling in the gamma lobe mus

173 the properties of GABAergic neurons and the cellular effects of GABA have not been described in Dros

174 We have previously used LCLs to examine the cellular effects of genetic variants that modulate the e

175 protein kinases (MAPKs) mediate many of the cellular effects of growth factors, cytokines and stress

176 The immunologic and cellular effects of herpesvirus infections contribute to

177 Together, these distinct cellular effects of Hh signaling in neural progenitor ce

178 Results from recent studies suggest that the cellular effects of hydrogen sulfide are mediated in par

179 omyopathy and are not fully explained by the cellular effects of hyperglycemia alone.

180 A limited number of studies show the cellular effects of hypertonic saline and no studies, to

181 Most of the cellular effects of hypoxia are mediated by O2-labile hy

182 targets and function of TRMT1 to uncover the cellular effects of ID-causing TRMT1 mutations.

183 To determine the cellular effects of induced, oxidative DNA damage, we es

184 ol studies have focused on the molecular and cellular effects of inositol depletion without consideri

185 Therefore, cellular effects of intrabacterial ammonia generation un

186 ng nurse cells of the fly ovary to study the cellular effects of intracellular IIS components on lipi

187 Taken together with previous work on the cellular effects of LAR, the present results are consist

188 enosine 5'-phosphate (PAP), in mediating the cellular effects of lithium.

189 Many of the cellular effects of LPA and S1P are attributable to modi

190 )/Edg-4, and lpa(3)/lp(A3)/Edg-7 mediate the cellular effects of LPA.

191 ctivity of the autonomic nervous system, the cellular effects of MC4Rs on parasympathetic and sympath

192 The cellular effects of mitochondria- or surface-selective a

193 quitous second messenger responsible for the cellular effects of multiple hormones and neurotransmitt

194 Cellular effects of nanosecond-pulsed electric field exp

195 ne beta subunit, sGC mediates the widespread cellular effects of nitric oxide (NO).

196 However, the relationship between the cellular effects of norepinephrine and the impact of nor

197 noporation mediates and enhances the diverse cellular effects of nsPEF.

198 hat inhibition of PAK may be involved in the cellular effects of OSU-03012 in these cells.

199 Here we have examined the cellular effects of overexpression of SIRT1, the closest

200 d extend earlier work and to investigate the cellular effects of PANDAS antibodies on cholinergic int

201 y to different tumors, and the molecular and cellular effects of PD-1 blockade.

202 We have also investigated the cellular effects of peroxynitrite in HaCaT cells, a huma

203 ese results help reconcile seemingly opposed cellular effects of Pfn1, provide new insights into the

204 The network and cellular effects of PGE2 and TTX treatments reversed wit

205 Here, we characterize the biochemical and cellular effects of PIAs.

206 signaling mechanisms underlying the observed cellular effects of PLK1 involve direct PLK1-dependent p

207 Our data suggest that the cellular effects of progerin are transduced, at least in

208 pression, and provides a novel mechanism for cellular effects of PTEN.

209 effectors have been described to mediate the cellular effects of Rap1 in a context-dependent manner.

210 kinase inhibitor in intact cells or that the cellular effects of rapamycin are not mediated through g

211 It has been assumed that the cellular effects of reactive tetrahydroisoquinolines res

212 ors are widely expressed in neurons, but the cellular effects of receptor activation are unclear.

213 R) and retinoid X receptor (RXR) mediate the cellular effects of retinoids (derivatives of vitamin A)

214 190-deficient cells, we demonstrate that the cellular effects of Rnd expression are mediated by p190.

215 alance between the desirable and undesirable cellular effects of ROS.

216 Although these cellular effects of roscovitine are thought to be caused

217 We show that the pathway responsible for the cellular effects of S-nitrosothiols is specific for S-ni

218 e signaling mechanisms mediating the diverse cellular effects of S1P remain to be determined.

219 Notably, these cellular effects of small t are dependent on its interac

220 S1P(1-5)) have been shown to mediate various cellular effects of sphingosine 1-phosphate (S1P).

221 The cellular effects of SR1848 treatment are recapitulated a

222 Drugs that mirror the cellular effects of starvation mimics are considered pro

223 cades and could be involved in mediating the cellular effects of such signals.

224 Here, we report that the cellular effects of TcdA can be substantially enhanced v

225 ys the antibody-dependent enhancement of the cellular effects of TcdA.

226 y rodent neuronal culture model to study the cellular effects of TDP-43 dysfunction in hippocampal an

227 ors represent a common mechanism involved in cellular effects of tea polyphenols.

228 signaling proteins involved in mediating the cellular effects of TGF-beta(1).

229 mportance of ARF binding to the toxicity and cellular effects of the ADP-ribosylating bacterial toxin

230 rol CHO cells in a manner reminiscent of the cellular effects of the APP "Swedish mutation." The incr

231 In addition, cellular effects of the best dual inhibitors were determ

232 th TUBB4A reflect the selective and specific cellular effects of the causative mutations.

233 To distinguish the cellular effects of the different 5-HT2AR agonists, we d

234 nt study, we investigated the functional and cellular effects of the neuropeptide thyrotropin-releasi

235 In this study, we investigated the cellular effects of the unmodified and acetyl mini-chape

236 affect protein structure, the molecular and cellular effects of the V144M mutation are unknown.

237 rcaptopurine and other purine analogues, the cellular effects of these compounds remain relatively un

238 vitro As a further proof-of-concept test for cellular effects of these compounds, we performed proxim

239 cer therapeutics, but little is known of the cellular effects of these inhibitors on tumor vessels.

240 thin mammalian intracardiac ganglia, but the cellular effects of these neuropeptides remain poorly un

241 jective of the Lessons From Antagonizing the Cellular Effects of Thrombin-Acute Coronary Syndromes (L

242 ibits pedestal formation, revealing that the cellular effects of Tir and Map must be co-ordinately re

243 unknown mechanism by which IP may limit the cellular effects of TP.

244 We present a study of the cellular effects of TUBB4A mutations responsible for H-A

245 ion, but they can respond to and mediate the cellular effects of type I IFNs.

246 evaluated the expression, localization, and cellular effects of Us5/gJ.

247 id sequence, ultrastructural morphology, and cellular effects of VacA are unrelated to those of any o

248 Immune cellular effects of vasoactive intestinal peptide (VIP)

249 rtance of tumor phenotype in determining the cellular effects of VEGF and PDGF inhibitors on tumor ve

250 dies of viral latency, reactivation, and the cellular effects of viral infection will provide clues f

251 Evaluation of the cellular effects of XL177A reveals that selective USP7 i

252 This study compared the cellular effects of XL880 and XL184 with those of an RTK

253 s in a brain focal ischemia model and direct cellular effects on human umbilical vein endothelial cel

254 en suggested that molecules with significant cellular effects on retinoblastoma protein (pRb) or its

255 explore the structural, conformational, and cellular effects on the B-Raf kinase domain upon binding

256 We examined the cellular effects on tumor vasculature of a novel DNA oli

257 Investigations into the cellular effects produced by fostriecin treatment reveal

258 Cellular effects produced by mutant SOD1, including impa

259 sights into mechanisms for these contrasting cellular effects, protease activated receptor 3 (PAR3) a

260 TauNHCl has diverse cellular effects ranging from inhibiting the production

261 and increases expression of ins-16, and this cellular effect reduces AWA activity and AWA-expressed i

262 among telomeres, their regulation and their cellular effects remain elusive.

263 ccal enterotoxin B, which mimics some of the cellular effects seen in patients with severe bacterial

264 embrane GLUT1 was measured, thus providing a cellular effect similar to insulin, but on a transporter

265 yglutamine proteins may determine subsequent cellular effects such as nuclear localization and cellul

266 in their sequences, signaling partners, and cellular effects such as oncogenic transformation and cy

267 -8, possibly involved in regulating numerous cellular effects, such as effects on cell growth or cell

268 e can promote cancer progression by a direct cellular effect that is independent of its effect on the

269 ides are easily inactivated and have diverse cellular effects that are distinct from antimicrobial ac

270 that some tyrosine kinase inhibitors produce cellular effects that are mechanistically different from

271 also provides a rare example of TLR-mediated cellular effects that do not require gene induction and

272 e mechanistic target of rapamycin (MTOR) has cellular effects that may alter HIV infection through ot

273 ddition, angiotensin II also has a number of cellular effects that may contribute to disease pathogen

274 ) family of lipid mediators, elicits diverse cellular effects that range from mitogenesis to the prev

275 he molecular mechanisms in propofol-mediated cellular effect, the expression of programmed cell death

276 IL-6 exerts its cellular effects through a cell-surface receptor which a

277 Furthermore, glucose exerts many of its cellular effects through lipid mediators.

278 reasing evidence reveals that ROS have wider cellular effects through their role in many signal trans

279 oltage-gated calcium channels has widespread cellular effects upon a host of physiological processes

280 ription polymerase chain reaction to examine cellular effects upon compound addition.

281 rrhythmogenic consequences, we simulated the cellular effects using a new AP model, which reproduced

282 d with numerous receptors that mediate their cellular effects via activation of G(q)-type G proteins,

283 ironment mediating angiogenesis and invasive cellular effects via both EphrinB2 ligand-dependent and

284 w phosphorylation of a protein might achieve cellular effects via direct impacts on the protein's agg

285 he relationship between Hsp90 inhibition and cellular effects, we developed a method that measures dr

286 ical activities that might account for these cellular effects, we found that monodansylcadaverine (MD

287 ce HIV protease inhibitors have "off target" cellular effects, we studied whether darunavir, the most

288 ns was investigated in this study, and their cellular effects were compared with those caused by the

289 entiation and G0 arrest, where the doses for cellular effects were consistent with the transcriptiona

290 t similar levels in nuclear chromatin, their cellular effects were different in relation to cell-kill

291 MiR-21-mediated cellular effects were further confirmed in vivo in ballo

292 Moreover, cellular effects were observed at 1-Chl concentrations s

293 These cellular effects were preceded by fragmentation of the G

294 e brain and periphery of NVHL animals; these cellular effects were related to behavioral improvement.

295 These cellular effects were, in part, explained by the effect

296 study reveals the behavioral impact of this cellular effect, whereby the level of GIRK3 expression i

297 o studies showed that EMD stimulates various cellular effects, which could potentially enhance wound

298 o fractionate EMD and associate its specific cellular effects with different molecular weight fractio

299 ew mechanisms by which mutant p53 exerts its cellular effects, with a particular focus on the burgeon

300 nction of cholinergic modulation to specific cellular effects within these regions.