ライフサイエンスコーパス: cellular metabolism

1 intain endocrine cell function, and regulate cellular metabolism.

2 oefficients are sufficient to keep pace with cellular metabolism.

3 oliferation, restored apoptosis and improved cellular metabolism.

4 gulating innate immune memory by controlling cellular metabolism.

5 gene transcription and the reprogramming of cellular metabolism.

6 reduced proliferation, differentiation, and cellular metabolism.

7 involved in the donation of methyl groups in cellular metabolism.

8 evidence that VCP/p97 acts as a regulator of cellular metabolism.

9 D1 axis, which leads to the reprogramming of cellular metabolism.

10 tegrity of the endolysosomal homeostasis and cellular metabolism.

11 ng lipid peroxides, which are by-products of cellular metabolism.

12 NRF2 is emerging as a major regulator of cellular metabolism.

13 solate the most immediate effects of NRF2 on cellular metabolism.

14 hospholipids, with profound consequences for cellular metabolism.

15 system development, oxygen homeostasis, and cellular metabolism.

16 quite distinct in the context of changes in cellular metabolism.

17 networks (GEMs) can assist in understanding cellular metabolism.

18 onditions, suggesting its role in modulating cellular metabolism.

19 s, we reveal that EVI1 overexpression alters cellular metabolism.

20 proteasome activity in CD8+ T cells affected cellular metabolism.

21 mitochondrial oxidative phosphorylation and cellular metabolism.

22 inction, and could also potentially regulate cellular metabolism.

23 egulatory targets coupling energy storage to cellular metabolism.

24 tochondrion is the primary energy source for cellular metabolism.

25 increasingly understood to be regulators of cellular metabolism.

26 of the apoplast has a profound influence on cellular metabolism.

27 e enzymes to form NADH is a key component of cellular metabolism.

28 ecycling, and generating molecules that fuel cellular metabolism.

29 or energy homeostasis and tightly coupled to cellular metabolism.

30 drawing a direct link between DNA repair and cellular metabolism.

31 ormation about the topology and operation of cellular metabolism.

32 ses mTORC1 activity, leading to dysregulated cellular metabolism.

33 naling cascade regulates multiple aspects of cellular metabolism.

34 er understand the burden of glycosylation on cellular metabolism.

35 ich hepatic autophagy monitors and regulates cellular metabolism.

36 monocytes and macrophages induces changes in cellular metabolism.

37 staining enzymes that are required for basic cellular metabolism.

38 d various carbohydrate intermediates used in cellular metabolism.

39 a dynamic network, playing a central role in cellular metabolism.

40 or providing energy and carbon skeletons for cellular metabolism.

41 les served as the light harvester to sustain cellular metabolism.

42 dependent deacetylase, is a key regulator of cellular metabolism.

43 y attributes, is significantly influenced by cellular metabolism.

44 ed protein kinase (AMPKalpha), the sensor of cellular metabolism.

45 data suggest a novel role of GRP78-mediating cellular metabolism.

46 ens a new avenue for the characterization of cellular metabolism.

47 rules that govern organelle integration into cellular metabolism.

48 eraction of OTUB1 with proteins important in cellular metabolism.

49 oxidase (oxCCO), an intracellular marker of cellular metabolism.

50 ognized as a disease involving dysfunctional cellular metabolism.

51 inner mitochondrial membrane that regulates cellular metabolism.

52 time monitoring, selection and regulation of cellular metabolism.

53 ing enzyme and may have a role in endogenous cellular metabolism.

54 pacity limits directly to limits on cerebral cellular metabolism.

55 ogram through chromatin regulation to rewire cellular metabolism.

56 ty of high-energy phosphates and ultimately, cellular metabolism.

57 tly suppressed NK cell effector response and cellular metabolism.

58 igated the global effects of methotrexate on cellular metabolism.

59 l and genetic perturbations by reprogramming cellular metabolism.

60 related to both nervous system function and cellular metabolism.

61 l therapeutic strategies by dually targeting cellular metabolism.

62 ulation of the non-Faradaic impedance due to cellular metabolism.

63 ckout mice, revealing broad implications for cellular metabolism.

64 To ensure a faithful representation of cellular metabolism after cell sorting, we benchmarked s

65 To understand the role of the enzyme in cellular metabolism, Aldh1l1(-/-) mice were generated us

66 it is also becoming apparent that changes in cellular metabolism also contribute to circadian timing,

67 isms that mitigate physiological damage from cellular metabolism and (2) extrinsic rather than intrin

68 y lymphoid tissues but necessary to regulate cellular metabolism and accumulation of CD103(+) DCs and

69 ther -omics data for the scientific study of cellular metabolism and bioengineering purposes.

70 hat arginine plays a connecting role between cellular metabolism and c-di-GMP signalling in P. putida

71 s is essential to advancing our knowledge of cellular metabolism and can be achieved by tracking an i

72 Taken together, we find that rhythms in cellular metabolism and circadian proteins work together

73 echanism can serve for general regulation of cellular metabolism and contribute to coordination of ge

74 n programmes are able to sense the status of cellular metabolism and control the switch between anabo

75 etabolic sensor LKB1 is critical to maintain cellular metabolism and energy homeostasis in Tregs.

76 he unfolded protein response, autophagy, and cellular metabolism and exploit these pathways to their

77 e that hepatic functionality depends more on cellular metabolism and extracellular nutrients than on

78 arity for describing the dynamic response of cellular metabolism and for identifying target genes for

79 biochemical changes results in alteration of cellular metabolism and function in the obese state rela

80 ses encode the information required to usurp cellular metabolism and gene regulation and to enable th

81 eal a previously hidden relationship between cellular metabolism and genome evolution and provide new

82 s a central cell growth regulator connecting cellular metabolism and growth with a wide range of envi

83 compounds that support, or are products of, cellular metabolism and growth) is entirely controlled b

84 ducible kinases (SIKs) are key regulators of cellular metabolism and growth, but their role in cardio

85 species, and aspartate are key regulators of cellular metabolism and growth.

86 ty by iron homeostasis is a prerequisite for cellular metabolism and growth.

87 lular signaling pathways that are central to cellular metabolism and growth.

88 onent of pathways involved in the control of cellular metabolism and has a role in regulating immune

89 Ribosome biogenesis is crucial for cellular metabolism and has important implications for d

90 nd metabolism is an important contributor to cellular metabolism and health.

91 The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA pro

92 autophagy, a recycling process important for cellular metabolism and homeostasis.

93 ential organelles with numerous functions in cellular metabolism and homeostasis.

94 Mitochondria have various roles in cellular metabolism and homeostasis.

95 tography tandem mass spectrometry, we mapped cellular metabolism and identified spatially defined met

96 n may play a role in the interaction between cellular metabolism and important cellular functions.

97 roles of class I PI3Ks in the regulation of cellular metabolism and in immune system functions, two

98 Ferroptosis, a cell death process driven by cellular metabolism and iron-dependent lipid peroxidatio

99 tracellular matrix (ECM) regulates adipocyte cellular metabolism and is altered in obesity and type 2

100 nslation remains in excellent synchrony with cellular metabolism and its energy reserves.

101 a pervasive model organism for investigating cellular metabolism and its regulation by signaling proc

102 ther chemicals, as well as investigations of cellular metabolism and leveraging -omics data.

103 B) in Belgium, and her laboratory focuses on cellular metabolism and metabolic regulation.

104 Livers are cooled to reduce cellular metabolism and minimize ischemic injury.

105 , where an oxygen gradient is established by cellular metabolism and physical constraints.

106 n in the environment is a strong effector of cellular metabolism and physiology.

107 vated T cells, along with markers related to cellular metabolism and plasma cytokines.

108 ess and highlight that the interplay between cellular metabolism and posttranslational modification u

109 Tsc2 induction inhibits mTORC1 to suppress cellular metabolism and prevent acidosis-induced DNA dam

110 These divergent changes in cellular metabolism and programming form the basis for p

111 reticulum (ER) is a fundamental organelle in cellular metabolism and signal transduction.

112 Cellular metabolism and signaling pathways are key regul

113 As a central hub of cellular metabolism and signaling, the mitochondrion is

114 Mitochondria are key for cellular metabolism and signalling processes during vira

115 regulatory pathways, inflammatory mediators, cellular metabolism and stress response genes, we find t

116 channels provide a significant link between cellular metabolism and the antiviral immune response in

117 Crosstalk between cellular metabolism and the epigenome regulates epigenet

118 roles of mTOR signaling in the regulation of cellular metabolism and the pathogenesis of cancer.

119 articular the integration of complement with cellular metabolism and the potential implications in in

120 in MDA-MB-231 breast cancer cells on global cellular metabolism and to probe for unknown endogenous

121 of lysine acylation, which is implicated in cellular metabolism and transcriptional control.

122 onths of life correspond with differences in cellular metabolism and transcriptomic profiles at birth

123 na requires adequate oxygenation to maintain cellular metabolism and visual function.

124 .Sle3 lupus mice and patients present a high cellular metabolism, and a treatment combining 2-deoxy-D

125 t SR9009 can decrease cell viability, rewire cellular metabolism, and alter gene transcription in hep

126 ram that includes B-cell receptor signaling, cellular metabolism, and epigenetic regulation.

127 bones and teeth, its pervasive regulation of cellular metabolism, and its functionalization of numero

128 glutamine are the major nutrients that fuel cellular metabolism, and the pathways utilizing these nu

129 d in alterations in CD4+CD25+FOXP3+ T-cells, cellular metabolism, and transcription factors involved

130 ondria play an important role in controlling cellular metabolism, apoptosis, and innate immunity.

131 receptor (Ryr2) Ca(2+) release channels and cellular metabolism are both disrupted in heart disease.

132 ecent studies have suggested that changes in cellular metabolism are important to these processes.

133 Current methods for imaging cellular metabolism are limited by low sensitivities, co

134 Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome.

135 Chromatin modification and cellular metabolism are tightly connected.

136 abolism-conditions in which intermediates of cellular metabolism are transferred from one cell to ano

137 nisms coordinating lipid storage in LDs with cellular metabolism are unclear but relevant to obesity-

138 togen-activated protein kinase signaling and cellular metabolism, as well as a lower oxidation state

139 The results showed increased levels of cellular metabolism associated with attended processing

140 Underpinning T(mem) survival is a shift in cellular metabolism away from aerobic glycolysis towards

141 tocin did not affect the glutathione-related cellular metabolism before OGD, oxytocin modulated the e

142 The chromatin landscape and cellular metabolism both contribute to cell fate determi

143 er, little is known regarding how changes in cellular metabolism, both within the cancer cell and the

144 ology to make great strides in interrogating cellular metabolism but does not provide sufficient insi

145 tabolomics experiments provide a snapshot of cellular metabolism but remain challenging to interpret

146 an clocks play important roles in regulating cellular metabolism, but the reciprocal effect that meta

147 in that they spatially segregate aspects of cellular metabolism, but they do so by building not a li

148 ation is associated with profound changes in cellular metabolism, but whether tracking these can impr

149 Cancer transformations profoundly alter cellular metabolism by increasing glucose consumption vi

150 allow disease tracking and interrogation of cellular metabolism by magnetic resonance.

151 chondrogenesis, SOX9 acts as a regulator of cellular metabolism by suppressing oxidation of fatty ac

152 rrant immune responses and that manipulating cellular metabolism can beneficially enhance or temper i

153 Evidence suggests that the rewiring of cellular metabolism can regulate macrophage function.

154 c and glycolytic conditions, perturbation of cellular metabolism causes cell death.

155 the relationship between exogenous cysteine, cellular metabolism, cellular localization, and Hg(II) c

156 a lot of enthusiasm with the prediction that cellular metabolism could be manipulated to either enhan

157 trate that multiple GBF1 mutants inactive in cellular metabolism could still be fully functional in t

158 are multifunctional organelles with roles in cellular metabolism, cytotoxicity, and signaling.

159 that NAT1 expression differentially affects cellular metabolism dependent on the level of expression

160 YAP appears to reprogram cellular metabolism, diverting substrates away from the

161 standing of the molecular events controlling cellular metabolism downstream of PI3K and AKT and of ho

162 As are necessary for modulating the shift in cellular metabolism during hibernation and regulating ne

163 the GID E3 ligase, an important regulator of cellular metabolism during the switch between gluconeoge

164 Cellular metabolism dynamically regulates the epigenome

165 reby providing insight into how HCMV hijacks cellular metabolism for its replication, and sheds light

166 These results reveal a connection between cellular metabolism, gene regulation, and neural plastic

167 Mitochondria play an essential role in cellular metabolism, generation of reactive oxygen speci

168 complex 1 (mTORC1) is a master regulator of cellular metabolism, growth, and proliferation.

169 ell responses, it is now becoming clear that cellular metabolism has direct roles in regulating immun

170 Cellular metabolism has emerged as a critical determinan

171 minance of phosphorylation as a regulator of cellular metabolism has fostered the development of pept

172 Glucose, a chief energy source in cellular metabolism, has a significant role in cell prol

173 sing volume of data suggests that changes in cellular metabolism have a major impact on the health of

174 olves global reprogramming of transcription, cellular metabolism, hormone signalling and chromatin mo

175 een successfully used to assess and engineer cellular metabolism; however, GEMs of phototrophic metab

176 Ammonia is a ubiquitous by-product of cellular metabolism; however, the biological consequence

177 a range of potentially beneficial effects on cellular metabolism, immune function, and gene transcrip

178 ion (early lactation into the dry period) on cellular metabolism in activated bovine CD4(+) T cells.

179 Cellular metabolism in hematopoietic stem cells (HSCs) i

180 thod that allows for real-time assessment of cellular metabolism in isolated, intact long skeletal mu

181 Cellular metabolism in mammalian cells represents a chal

182 These data redefine the role of cellular metabolism in memory cell differentiation, show

183 Recent advances highlight a pivotal role for cellular metabolism in programming immune responses.

184 tor, have effects on adipogenic pathways and cellular metabolism in resident macrophages and T cells.

185 However, whether alkylation affects cellular metabolism in the absence of AAG-mediated BER i

186 In the past few years, the decisive role of cellular metabolism in the fate and activity of immune c

187 e generate a single-cell resolution atlas of cellular metabolism in the TME, detailing how it changes

188 ses, such as HDAC3, have been shown to alter cellular metabolism in various tissues.

189 tablished miR-211 as a critical regulator of cellular metabolism in vitiligo cells.

190 DPP is found to disturb cellular metabolism including increased energy depletion

191 Altered cellular metabolism, including an increased dependence o

192 differentiation is accompanied by changes in cellular metabolism, including increased glycolysis, to

193 traditional media, had widespread effects on cellular metabolism, including on the metabolome, redox

194 the c-MET tyrosine kinase pathway; shifts in cellular metabolism, including up-regulation of hypoxia

195 associated with a striking reprogramming of cellular metabolism induced by a profound modification o

196 Although ferroptosis and cellular metabolism interplay with one another, whether

197 Reprogrammed cellular metabolism is a common characteristic observed

198 Reprogramming of cellular metabolism is a hallmark feature of cancer cell

199 Altered cellular metabolism is a hallmark of cancer, and much of

200 Altered cellular metabolism is a hallmark of gliomas.

201 Impaired oxygen and cellular metabolism is a hallmark of ischaemic injury in

202 Deregulated cellular metabolism is a hallmark of tumors.

203 Cellular metabolism is a key regulator of cell fate, inc

204 Altered cellular metabolism is an important characteristic and d

205 Altered cellular metabolism is believed to be an important contr

206 e of ATP-sensitive K(+) channels (K(ATP)) to cellular metabolism is coordinated by three classes of n

207 Elucidating signaling pathways that regulate cellular metabolism is essential for a better understand

208 changes in signal transduction pathways and cellular metabolism is essential for effective NK cells

209 Precise regulation of cellular metabolism is hypothesized to constitute a vita

210 unction of Bax, a pro-apoptotic regulator of cellular metabolism is implicated in neurodegenerative d

211 Rewiring cellular metabolism is important for activation of immun

212 ding its regulation and overall influence on cellular metabolism is of significant interest.

213 Unfortunately, such rewiring of cellular metabolism is often carried out sequentially an

214 ic fluxes (i.e. the rate of each reaction in cellular metabolism) is of particular interest for metab

215 Despite its importance as a nutrient for cellular metabolism, its source has been unclear.

216 s from obese mice were found to have altered cellular metabolism, largely characterized by an increas

217 KC with studies suggesting localized altered cellular metabolism leading to the development of cornea

218 tional compensation mechanism that regulates cellular metabolism levels according to processing deman

219 on mechanism is required to regulate limited cellular metabolism levels in line with attended task de

220 We posit that changes in cellular metabolism may be a common denominator of innat

221 oliferator-activated receptor-alpha-mediated cellular metabolism may play an important role in sepsis

222 osome function, which alters many aspects of cellular metabolism, may be important.

223 some was attributed a rather passive role in cellular metabolism merely transforming bulk material in

224 properties of products and intermediates of cellular metabolism (metabolites), highlighting their ke

225 most solid tumors and often lead to altered cellular metabolism, metastasis, and drug resistance.

226 the GOF activities, including alterations in cellular metabolism, might vary between the different p5

227 Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary hypertensi

228 environment due to several factors including cellular metabolism of compounds, protein-protein intera

229 rganize subcellular membranes and rewire the cellular metabolism of host cells to achieve viral repli

230 Visualizing cellular metabolism of nucleic acids, proteins, and lipi

231 ethers and their oxidized derivatives on the cellular metabolism of WEHI-164 and HEK-293T cell lines

232 ional glycolytic pathway and its role in the cellular metabolism ofMtbhas yet to be understood.

233 ironmental factors may damage the DNA, alter cellular metabolism or affect the ability of cells to in

234 ydrolysis, reactive oxygen species, aberrant cellular metabolism or other perturbations that cause DN

235 hondrial morphology shifts rapidly to manage cellular metabolism, organelle integrity, and cell fate.

236 d OXPHOS, depleted cellular ATP, and altered cellular metabolism pathways that compromise their survi

237 monstrates that cancer stem cells (CSCs) and cellular metabolism play a pivotal role in metastasis.

238 Recent studies indicate that cellular metabolism plays a key role in supporting immun

239 Hence, cellular metabolism plays a vital role beyond simply the

240 Cellular metabolism plays important functions in dictati

241 x effects on genetic stability, epigenetics, cellular metabolism, proliferation, and survival, the co

242 pathway, which serves as a core regulator of cellular metabolism, proliferation, survival, and autoph

243 cted roles of cytosine methylation in global cellular metabolism providing evidence for a 'core' m5C

244 s dominated by DO concentration (affected by cellular metabolism), rather than potential nucleation s

245 Cellular metabolism regulates immune cell activation, di

246 protein complexes such as those involved in cellular metabolism remains an important question.

247 in turn provide greater understanding of how cellular metabolism shapes T-cell responses.

248 d quantitative analysis of these markers for cellular metabolism show in response to doxorubicin, NAD

249 f temperature compensation as fV , M O2, and cellular metabolism significantly decreased following th

250 ry effectors of cellular function, including cellular metabolism, structural dynamics, and informatio

251 Finally, changes in cellular metabolism, surface markers, and gene expressio

252 he alterations in mitochondrial function and cellular metabolism that are necessary to initiate and s

253 Whether concurrent changes in the cellular metabolism that occur upon TLR activation influ

254 ation, gene regulation, and other aspects of cellular metabolism that reinforce thermostable polymera

255 associated with alterations in systemic and cellular metabolism that resolves following successful a

256 ystems-biology computational method to study cellular metabolisms that are assumed to be in a steady

257 genesis is dependent on the reprogramming of cellular metabolism, the metabolic pathways engaged in t

258 Autophagy impacts cellular metabolism, the proteome, and organelle numbers

259 diseases are now linked to abnormalities in cellular metabolism, the pulmonary community has only re

260 ounced changes in cell cycle progression and cellular metabolism, thereby highlighting its putative r

261 process that mends DNA lesions formed during cellular metabolism; these lesions include double-strand

262 ion of cytoprotective genes, which reprogram cellular metabolism through activation of the integrated

263 of patients with ADPKD), may in part affect cellular metabolism through direct effects on mitochondr

264 that metabolic alterations in cancer rewire cellular metabolism through unconventional pathways.

265 ng network has diverse downstream effects on cellular metabolism, through either direct regulation of

266 Viruses are known to perturb host cellular metabolism to enable their replication and spre

267 biology is that oncogenes actively reprogram cellular metabolism to enable tumors to survive and prol

268 influencing myriad molecular processes from cellular metabolism to epigenetic states of the genome.

269 o act as important regulators that reprogram cellular metabolism to induce aerobic glycolysis.

270 randial blood glucose, an enforced change in cellular metabolism to maintain glucose homeostasis.

271 eering (MGE) is a technique for manipulating cellular metabolism to modulate glycosylation.

272 alters gene expression in bacteria to adjust cellular metabolism to nutrient availability.

273 ability of cardiomyocytes, using a model for cellular metabolism to predict the levels of ATP followi

274 ation.IMPORTANCE Viruses can manipulate host cellular metabolism to provide energy and essential bios

275 d repair mitochondrial function and to adapt cellular metabolism to stress.

276 Rewiring cellular metabolism to support anabolic processes is a f

277 cer cells undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs.

278 n Cytomegalovirus (HCMV) infection modulates cellular metabolism to support viral replication.

279 from the down-modulation of many aspects of cellular metabolism to the hijacking of specific host fu

280 In addition, they convey oscillations in cellular metabolism to the membrane by sensing adenine n

281 emerging evidence that links alterations in cellular metabolism to the pathobiology of several commo

282 a constrained metabolic network model of the cellular metabolism, to the time-varying nature of the e

283 onse in mammals is the complex remodeling of cellular metabolism towards aerobic glycolysis.

284 ation of stem cell, cell survival/death, and cellular metabolism under both physiological and patholo

285 yruvate and acetyl-CoA play central roles in cellular metabolism, understanding PDC regulation is piv

286 ntitative mapping of the in vivo dynamics of cellular metabolism via non-invasive imaging contributes

287 ing restricted viral replication by altering cellular metabolism via upregulation of the enzyme IRG1

288 ecause both IDH1 and p53 are known to affect cellular metabolism, we compared the requirements for gl

289 bitors of pathways important for controlling cellular metabolism, we found here that the cAMP-depende

290 s, e.g. genes related to cell wall and basic cellular metabolism were highly expressed in immature le

291 objectives is also needed for engineering of cellular metabolism, where there is interest in mitigati

292 iptional activation, cytokine expression and cellular metabolism which collectively constitute a cont

293 an interplay between oxygen availability and cellular metabolism, which in turn has significant effec

294 ls from healthy volunteers enhanced in vitro cellular metabolism while inhibiting the mammalian targe

295 s, reduced cellular signaling, and increased cellular metabolism with associated tissue remodeling pa

296 Despite considerable research connecting cellular metabolism with differentiation decisions, the

297 a range of biological activities by linking cellular metabolism with membrane excitability.

298 nalling network integrates transcriptome and cellular metabolism with shoot-root coordination and dev

299 This leads to a functional heterogeneity of cellular metabolism within WAT that has potential impact

300 We found that genes with functions in cellular metabolism (YDC1, AAD4, ADE8, and SDH1), protei