ライフサイエンスコーパス: cellularity

1 ccounted for the largest increase in splenic cellularity.

2 rs including the rate of neoangiogenesis and cellularity.

3 having reduced TCR diversity despite normal cellularity.

4 l-scale materials systems based on synthetic cellularity.

5 8(+) cells and a 20-fold reduction in thymic cellularity.

6 s within the wound, beta-catenin levels, and cellularity.

7 ficient was lower, consistent with increased cellularity.

8 e preferentially to bones with higher marrow cellularity.

9 ithelial branching and increased mesenchymal cellularity.

10 for some, but far from all, of the observed cellularity.

11 oration in plasma cells, and variable marrow cellularity.

12 ctions but not for in vivo measurement of BM cellularity.

13 ithelial branching and increased mesenchymal cellularity.

14 anged as the result of decreased bone marrow cellularity.

15 h-frozen lung tissue with at least 70% tumor cellularity.

16 wever, these mice possess near-normal thymic cellularity.

17 penia, and a marked reduction in bone marrow cellularity.

18 ling staining was done to quantify apoptotic cellularity.

19 on measurements depend on factors other than cellularity.

20 factor-alpha, and proximal aorta macrophage cellularity.

21 roliferation in an attempt to restore T cell cellularity.

22 mice deficient in Egr1 have increased thymic cellularity.

23 their dense extracellular matrix and sparse cellularity.

24 rating murine neutrophils but not neutrophil cellularity.

25 m, PPARD gene deletion resulted in increased cellularity.

26 vel secreted regulator of mesenchymal tissue cellularity.

27 vested constructs exhibited a high degree of cellularity.

28 e severity of skin disease as well as dermal cellularity.

29 an diffusivity was correlated with increased cellularity.

30 There was no difference in the cellularity (1.58 vs. 1.37; p = 0.2554), or in the sensi

31 o compare the effect of metal deposition and cellularity, a linear mixed effects model was used to fi

32 cyte compartment, accounting for recovery of cellularity accompanied by loss of TCR diversity.

33 n results in a 5-fold reduction in thymocyte cellularity, accompanied by developmental arrest at the

34 Perivascular cellularity agreement among investigators significantly

35 Importantly, reduction in BM cellularity alone can reproduce HSPC expansion.

36 als are associated with decreased lymph node cellularity and a decline in TH1 development.

37 t clone showed a lower degree of bone marrow cellularity and a higher frequency of developing chromos

38 Negative correlation was found between cellularity and ADC metrics of common pediatric cerebell

39 There was no correlation between cellularity and ADC ratio.

40 find that there are independent signals for cellularity and aging.

41 cell homeostasis under conditions of normal cellularity and also is required to mediate Flt3 ligand-

42 ) scaffolds revealed significantly increased cellularity and altered the phenotypes of endothelial pr

43 dial infarction (MI) due to rapid changes in cellularity and an inability to characterize both ECM mi

44 , which are characterized by increased tumor cellularity and angiogenesis.

45 the evolution of protocells, eukarya, multi-cellularity and animal societies.

46 lly striking changes were observed in spleen cellularity and architecture, and infected mice exhibite

47 enitor stage, resulting in reduced thymocyte cellularity and blocks at the double-negative and double

48 ively, and our histologic analyses confirmed cellularity and cell size were the likely underlying sou

49 dent dermal population resulted in decreased cellularity and collateral damage in the tissue during v

50 Crypt length, crypt cellularity and crypt cell proliferation were assessed i

51 26a1 (-/-) mice showed increased bone marrow cellularity and decreased frequency of erythroid progeni

52 or a 27 G vitrector may have better overall cellularity and diagnostic yield when compared to a 27 G

53 gene deletion are associated with reduced SZ cellularity and early onset OA.

54 1-deficient mice display increased thymocyte cellularity and enhanced proliferation of thymocytes and

55 Microdissection enriches tumour cellularity and enhances mutation calling.

56 complexity, including the evolution of multi-cellularity and eusociality.

57 P529 reduced cellularity and expression of collagen, fibronectin, and

58 ormal endothelium with increased endothelial cellularity and expression of lineage markers for mature

59 roved difficult to resolve due to poor tumor cellularity and extensive genomic instability.

60 derived TM like cells (iPSC-TM) restores TM cellularity and function in human eyes obtained from old

61 genotypes (FCG) mice and popliteal lymphnode cellularity and gene expression.

62 Cellularity and glycosaminoglycans content were signific

63 ast some of the rapid recovery of myocardial cellularity and heart size.

64 ic disease, depicting disease with increased cellularity and helping to differentiate benign from mal

65 ation as a primary signal reduced the spleen cellularity and largely abrogated asthma susceptibility

66 ns exhibit a substantial reduction in thymic cellularity and limited CD4(-)CD8(-) (double-negative) t

67 S exhibited substantial reductions in thymic cellularity and limited CD4- CD8- double-negative (DN) 3

68 e bone marrow failure (i.e., low bone marrow cellularity and low counts in multiple blood lineages) h

69 associated with the recovery of bone marrow cellularity and mature blood cell recovery at 21-30 days

70 oid tumors, no correlation was found between cellularity and mean tumor ADC and ADC ratio.

71 ther, negative correlation was found between cellularity and mean tumor ADCs (rho = -0.737, P < .05)

72 s, bone marrow colony forming units, sternal cellularity and megakaryocyte numbers in drug treated mi

73 obing characteristics of tumour vascularity, cellularity and metabolism which critically contribute t

74 larity and tumor cell alterations, including cellularity and micronecrosis.

75 Negative correlation was found between cellularity and minimum tumor ADC in atypical teratoid r

76 histology, with a mean difference of -0.52% cellularity and most differences within +/-2% cellularit

77 rogenous owing to intratumoral variations in cellularity and necrosis.

78 joints subjected to ACLT displayed increased cellularity and neovascularization on days 7 and 28 post

79 ndings of 2 pCLE criteria, abundant alveolar cellularity and perivascular cellularity (PVC), were ass

80 le in the degeneration-associated loss of NP cellularity and phenotype.

81 mmune cells at the injection site, but their cellularity and phenotypes were different from those in

82 Tumour cellularity and proliferation were quantified using hist

83 nction as a surrogate marker for both tissue cellularity and response to treatment that occur earlier

84 ese tissues in older animals display loss of cellularity and senescence becomes predominant.

85 tration was positively correlated with tumor cellularity and significantly differed between high- and

86 ll-derived BLyS is dispensable for normal GC cellularity and somatic hypermutation, it is required fo

87 creasing blood cell counts, BM hematopoietic cellularity and stem and progenitor cell clonogenicity i

88 ed T-cell precursors showed increased thymic cellularity and substantially improved donor T-cell chim

89 ) and various cytokines, with differences in cellularity and target immunoreactivity scores analyzed

90 Diffusion MRI can shed light on tumor cellularity and the disruption of white matter tracts in

91 releasing chemoattractive signals increases cellularity and tissue formation after injury.

92 interventions is characterized by increased cellularity and tissue remodeling.

93 l processes in glioblastoma, including tumor cellularity and vascularity, metabolite expression, and

94 However, the increased cellularity and vasogenic oedema associated with inflamm

95 rum imaging resolves inflammation-associated cellularity and vasogenic oedema in addition to accounti

96 ctor related to overall and lineage-specific cellularity and was significantly associated with JAK2 V

97 ound that TIMP-1(-/-) mice have decreased BM cellularity and, consistent with this finding, TIMP-1(-/

98 Glaucoma patients have reduced TM cellularity and, frequently, elevated IOP.

99 eparate the confounding effects of increased cellularity and/or grey matter contamination, allowing s

100 ogic measurements of primary tumor (size and cellularity) and nodal metastases (number and size) for

101 (-/-) mice, bone marrow chimeras with normal cellularity, and a selective depletion of CD11c(hi) dend

102 of erythrocytes), increased the bone marrow cellularity, and alleviated stress hematopoiesis.

103 tology was not as good (mean difference, -7% cellularity, and differences between 5% and -20%).

104 ivision, haematopoietic stem-cell frequency, cellularity, and erythropoiesis in the spleen.

105 ely aligned collagen fibers, normal level of cellularity, and functional restoration.

106 Thymi of primary donor mice showed reduced cellularity, and immunophenotypic analysis demonstrated

107 and compared with microvessel density (MVD), cellularity, and micronecrosis by using the Pearson corr

108 , platelet count, transfusion dependency, BM cellularity, and mutant SF3B1 and inversely with hemoglo

109 e of BM suppression, have anemia, reduced BM cellularity, and showed profound reduction in BM B cell

110 st atherosclerosis by maintaining structure, cellularity, and size of ATLOs though VSMC-LTbetaRs did

111 hances the HSPC engraftment kinetics, the BM cellularity, and the number of progenitors per tibia of

112 with a loss of HMGB2 expression and reduced cellularity, and this contributes to the development of

113 nclusion: Because receptor density and tumor cellularity appear to be independent, potentially comple

114 Conclusion: As receptor density and tumor cellularity appear to be independent, potentially comple

115 Bone volume, cellularity, areal bone mineral density, osteoblast gene

116 Increased tumor cellularity as reflected by restricted MRI diffusion may

117 We identified patient age and tumor cellularity as variables that frequently confound the me

118 ults in a dramatic loss of the thyroid gland cellularity, associated with down-regulation of thyroid

119 release of collagenase and PDGF-AB increases cellularity at the interface and within the scaffold, as

120 Transition in cellularity at the radiological margin did not differ ac

121 iated with a profound reduction in cartilage cellularity attributable to increased cell death.

122 diffusion basis spectrum imaging-determined cellularity, axon and myelin injury metrics closely corr

123 is measure is not predictive of total marrow cellularity, because the biopsy volume is typically smal

124 Lck-Cre transgene greatly diminished thymic cellularity, blocked thymocyte development at the double

125 ellularity and most differences within +/-2% cellularity, but agreement between MP-IDEAL and histolog

126 es of marrow volume fraction and bone marrow cellularity by skeletal site.

127 In addition to survival studies, splenic cellularity, canonical markers of activation and prolife

128 7-/- mice revealed a similar extent of joint cellularity, cartilage destruction, and bone erosion des

129 Histology confirmed a reduction in joint cellularity, cartilage destruction, and bone erosion.

130 s subtype cases and only a minority of mixed cellularity cases, suggesting that B2M deficiency determ

131 ion of hnRNP L results in a decreased thymic cellularity caused by a partial block at the transition

132 Marked increases in bone marrow cellularity, CD34+ cell number, and frequency of early h

133 meters that allow control over cancer grade, cellularity, cell overlap ratio, image resolution, and o

134 ect in IL-21 signaling exhibit normal thymic cellularity, challenging the importance of this cytokine

135 ras displayed a dramatic reduction in thymic cellularity compared with control mice.

136 A 2.7-fold increase in ONH cellularity confirmed glaucoma model cell proliferation.

137 Tumour cellularity correlated positively with K(app) (rho = 0.5

138 ut mice had a significant decrease in thymic cellularity, corresponding with a 100-fold decrease in t

139 treated with an A2AR agonist, the glomerular cellularity, crescent formation, sclerotic glomeruli, an

140 was investigated by evaluating T-lymphocyte cellularity, cytokine concentration, and viral load.Meas

141 asurements were subsequently correlated with cellularity data obtained utilizing current-standard des

142 ing is associated with decreased bone marrow cellularity, decreased adaptive immune system function,

143 elta, we show that these mice had reduced NK cellularity, defective Ly49C and Ly49I NK subset maturat

144 amma(c) (-/-) Nonetheless, the difference in cellularity detected in thymus autonomy bore no impact o

145 ne marrow chimeras that reconstituted thymic cellularity developed beyond stage 0 precursors and yiel

146 In summary, NAc cellularity differences and/or the lack of running-induc

147 of haematopoietic stem cells and bone marrow cellularity during ageing, and severely impairs stem cel

148 tain relatively intact peripheral B-lymphoid cellularity during homeostasis, they exhibit poor B-lymp

149 capacity, plays a role in regulating thymus cellularity during ontogeny.

150 xically improves diffusion and that reducing cellularity enhances diffusive macromolecular transport

151 ced survival, severely decreased bone-marrow cellularity, erythroid anemia and B cell lymphopenia.

152 in both spontaneous losses of quiescence and cellularity, especially within the CD8 subset.

153 odeling (0.75), simple analysis of the tumor cellularity estimated from imaging data (0.73), and the

154 real-time, on-line metabolite monitoring and cellularity estimation.

155 Tissues with live cellularity exceeding 50% were considered viable.

156 choalveolar lavage protein concentration and cellularity following SEA challenge.

157 = 3.18; 95% CI: 1.23, 8.17), and with mixed-cellularity HL (OR = 4.25; 95% CI: 1.66, 10.90).

158 HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val

159 te parameter to account for patient-specific cellularity in BM mass predictive equations and is consi

160 enhanced inflammation as proven by increased cellularity in bronchoalveolar lavage (BAL), pulmonary t

161 FNgamma positivity, macrophage presence, and cellularity in herniated IVDs suggests a pattern of Th1

162 and revealed enlarged med-LNs with increased cellularity in MI-patients.

163 trated as noninvasive means for measuring BM cellularity in patients.

164 bolic data for the determination of scaffold cellularity in real-time non-destructively.

165 basis spectrum imaging to quantify baseline cellularity in the absence and presence of vasogenic oed

166 minyl transferase I (Mgat1) markedly reduced cellularity in the bone marrow and/or spleen and inhibit

167 s enhancement was characterized by increased cellularity in the bronchoalveolar lavage (BAL) fluid an

168 i-VEGF therapy--characterized by lower tumor cellularity in the central area, decreased pseudopalisad

169 Dermal cellularity in the contrast-treated group was fourfold t

170 c nerve revealed punctate regions of reduced cellularity in the ganglion cell layer and damage to opt

171 C57BL/6 genetic background exhibit increased cellularity in the granulocyte/myeloid progenitor compar

172 The N66S mutant virus caused increased cellularity in the lungs, as a result of monocyte and ne

173 antly, Tim-4 deficiency results in increased cellularity in the peritoneum.

174 Three years after the surgery, the cellularity in the stromal bed had not significantly cha

175 In fact, the observation of increased cellularity in tissues exposed to cyclic stress suggests

176 and in vitro analyses demonstrated higher TM cellularity in treated mice compared with littermate con

177 Limits on DC and T cellularity in, and flux through, LN constrain the magni

178 f p53 partially rescued the defect in thymus cellularity (in contrast to early B cells) of Smarca5-de

179 opoiesis, morphologic dysplasia and BM hyper-cellularity, in a knock-in mouse model in which cyclin E

180 w examinations demonstrated increased marrow cellularity, including cells of the neutrophil series.

181 ficient T cells but failed to restore normal cellularity, indicating that complement contributes to c

182 histologic analysis can be difficult in low-cellularity infiltrative gliomas.

183 The increased cellularity is accompanied by a four-fold decrease in ce

184 Although it has long been known that marrow cellularity is inversely correlated with G-CSF levels, t

185 that the inability to maintain normal thymic cellularity is likely caused by impaired maintenance of

186 Although this increase in splenic cellularity is often assumed to be due to the recruitmen

187 g a gene-trapped allele, we show that thymic cellularity is slightly reduced in the absence of Notch3

188 e current gold standard for measuring marrow cellularity is the bone marrow (BM) biopsy of the iliac

189 row adipose tissue, and expansion of myeloid cellularity, leading to increased circulating neutrophil

190 ing lymphocytes markedly increase lymph node cellularity, leading to organ expansion.

191 ting better collagen I deposition, decreased cellularity, less vascularity, and higher glycosaminogly

192 ypes of classic HL (nodular sclerosis, mixed cellularity, lymphocyte-depleted or lymphocyte-rich HL),

193 tion, increased bronchoalveolar lavage fluid cellularity, markedly impaired surfactant biophysical fu

194 differences in cellularity of tumors, tumor cellularity may not be the sole determinant of the diffe

195 space (rho = -0.912, P = .007) than with the cellularity metrics (n = 288) nuclear area (rho = 0.422,

196 ferences between gland component volumes and cellularity metrics for multiple groups.

197 Gland component volumes and cellularity metrics were correlated with Gleason pattern

198 er than changes in the conventionally cited "cellularity" metrics, are likely to be the major contrib

199 cartilage constructs with a depth-dependent cellularity mirroring that of native tissue.

200 ells combine to induce increasing degrees of cellularity, mitoses, hypoxia-induced neoangiogenesis an

201 ches were associated with depletion of organ cellularity, most prominent among the B-cell subset.

202 came the reduction of basal layer epithelial cellularity, mucosal thickness, and epithelial cell prol

203 w-derived cells does not affect lesion size, cellularity, necrosis, or inflammatory parameters in adv

204 studies were performed to deduce the minimum cellularity needed for genetic analysis.

205 features, including significantly increased cellularity, nuclear grade, and proliferation.

206 as complete blood counts, splenic and marrow cellularity, numbers and function of hematopoietic stem

207 d 19 of 25 (76.0%) exhibited invasive cancer cellularity of <=10%.

208 of 80 mL/min/1.73 m(2) or more, bone marrow cellularity of 40% or more or stored autologous hematopo

209 ived possessed viable TM, having a mean live cellularity of 71% (n = 14), comparable with freshly pos

210 neuronal survival, and markedly reduces the cellularity of adult retinas.

211 Despite markedly reduced cellularity of hematopoietic progenitors in E18.5 bone m

212 Cellularity of local mesenteric lymph nodes, including T

213 Instead, differences in the size and cellularity of lymph nodes were associated with decrease

214 An increase in the cellularity of multipotent progenitors is observed in yo

215 Mean live cellularity of nonviable tissue was 11% (n = 7).

216 IgG control and examined for the number and cellularity of pancreatic islets by immunofluorescence a

217 L-2 receptor beta cause an acute decrease in cellularity of Peyer's Patches while cell numbers in the

218 ene induced a transient increase in size and cellularity of skin-draining lymph nodes (LNs) in mice.

219 The diagnostic yield, the cellularity of smears and the rate of acquiring sufficie

220 The reduced cellularity of the anterior stroma in Fuchs dystrophy do

221 nificantly higher compared with the measured cellularity of the CC lining at P15.

222 spite the intensive proliferation, the total cellularity of the CC lining at the L4 spinal segment si

223 ntensity of proliferation and determines the cellularity of the CC lining in reference to lumbar spin

224 ction of mutant subclones down to 20% of the cellularity of the crypt (~50 of 250 cells).

225 F cytokine concentrations, area of CTII, and cellularity of the CTII were calculated.

226 s in the SF, and 4) synovium and subsynovium cellularity of the knee joints of rabbits subjected to A

227 s no correlation between the ADC metrics and cellularity of the pilocytic astrocytomas, medulloblasto

228 In p27Kip1-/-; p130-/- mice, the cellularity of the spleens but not the thymi is signific

229 ation of an internal control to evaluate the cellularity of the test material is an important feature

230 and IL-7ralpha (-) (/) (-) We found that the cellularity of the thymus grafts is influenced exclusive

231 We have visualized and quantified the live cellularity of the TM in situ.

232 In contrast, the cellularity of the trabecular meshwork in experimental (

233 was profoundly defective, exhibiting reduced cellularity of thymus and bone marrow, and stage-specifi

234 consumption, and lactate production) and the cellularity of tissue-engineered cultures comprised of r

235 that the large cell morphology and the high cellularity of tumor within affected mesorectal lymph no

236 n in tissues can be used to characterize the cellularity of tumors and are valuable in assessing thei

237 ty is generally attributed to differences in cellularity of tumors, tumor cellularity may not be the

238 d adverse events or reduction in bone marrow cellularity or blast count) was observed, followed by 33

239 ot have altered thymic or splenic lymphocyte cellularity or differentiation.

240 ains at E11.5, with no change in the overall cellularity or volume of each shared primordium.

241 noted in brachiocephalic artery lesion size, cellularity, or vessel wall apoptosis.

242 micro-computed tomography and biomechanics), cellularity (osteoblasts and osteoclasts), bone matrix (

243 antly higher than those of abundant alveolar cellularity (P < 0.01).

244 patients when stratified according to sputum cellularity (P = 0.034).

245 erated recovery of BM sinusoidal vessels, BM cellularity, peripheral blood white blood cells (WBCs),

246 article, we show a striking 65% reduction in cellularity, preferential development of gammadelta vers

247 cell (TEC) cell-cycle exit and restricts TEC cellularity preferentially in the cortical TEC compartme

248 he thymocytes drastically reduced the thymic cellularity, primarily by reducing proliferation of the

249 undant alveolar cellularity and perivascular cellularity (PVC), were assessed by 4 investigators fami

250 creased ADC, which correlated with increased cellularity (r = 0.77, P = .04), whereas no changes in A

251 haracteristics, bronchoalveolar lavage (BAL) cellularity, rates of respiratory tract infection, colon

252 urring temporal to T cell exhaustion, thymic cellularity reconstituted despite ongoing viral replicat

253 ce lacking Paf exhibited reduced bone marrow cellularity; reduced numbers of HSCs and committed proge

254 e stress might contribute to the decrease in cellularity reported in the TM tissue with both aging an

255 ymphocytes constituting <0.3% of total tumor cellularity, representing a significant improvement over

256 - 1.6% and 14.1 +/- 1.7% of the total plaque cellularity, respectively.

257 ies (proliferation decrease >/= 30% Ki-67 or cellularity response).

258 cerbated inflammatory responses and elevated cellularity resulted in lung injury, epithelial regenera

259 ated allelic imbalanced regions in low tumor-cellularity samples or in low-proportion tumor subclones

260 fects presumably account for the near-normal cellularity seen in lymph nodes of PSGL-1(null) mice.

261 ADC was significantly correlated with cellularity, stromal component, and nuclear-cytoplasmic

262 on, diffusion basis spectrum imaging-derived cellularity strongly correlated with numbers of cell nuc

263 d age, EBV-encoded RNA positivity, and mixed cellularity subtype of CHL.

264 Nodular sclerosis and mixed-cellularity subtypes had similar frequency of CT45 expre

265 s were found for nodular sclerosis and mixed cellularity subtypes.

266 ion and adipocyte diameter but not increased cellularity, suggesting that catch-up fat is primarily a

267 Their lymphoid organ size and cellularity, T and B cell subpopulations, Th cell and re

268 Corneal cellularity tends to normalize over time, and 3 years po

269 ll as increased draining lymph node size and cellularity, Th2 cytokine production in draining lymph n

270 ality to have less stroma, have higher tumor cellularity than primary tumors.

271 Differences in matrix content and cellularity that might explain the imaging findings were

272 Using PLS-DA, unknown regions of cellularity that were otherwise unidentifiable by SIMS c

273 ratinocytes and causes increased basal layer cellularity, thickened mucosa, and elevated epithelial c

274 atenin and resulted in increased basal layer cellularity, thickened mucosa, and elevated epithelial c

275 that allowed an indirect estimation of tumor cellularity; this was further refined by the development

276 mokine modulation may help orchestrate local cellularity, thus minimizing competition for space and r

277 pmental defects, ranging from reduced thymic cellularity to a complete block in T cell development.

278 ed herein can establish the diagnosis of low-cellularity tumors like glioma and could be adapted to t

279 contrast agent-enhanced (DCE)-MRI and tumor cellularity using diffusion-weighted MRI of the apparent

280 dendrogliomas are characterized by increased cellularity, vascular proliferation, small regions of ne

281 killed at various times, and lacrimal gland cellularity was analyzed by flow cytometry.

282 to the latest WHO classification, and tumor cellularity was calculated.

283 The increase in HSC cellularity was caused by both genetic lupus risk factor

284 Although thymic cellularity was comparable between wild type (WT) and DK

285 es now show that, in CD11a(-/-) mice, thymic cellularity was decreased and early T cell development w

286 Although thymic cellularity was diminished in p45(-/-) mice, transition

287 Lamina propria cellularity was evaluated by immunostaining and flow cyt

288 BAL cellularity was examined in relation to mortality (n = 1

289 Dermal cellularity was increased in contrast-treated green fluo

290 Loss of quiescence but not cellularity was inhibited by rapamycin.

291 A 90-fold decrease in thymic cellularity was observed in the dCK KO mice relative to

292 According to our calculations, the estimated cellularity was significantly higher compared with the m

293 Thymocyte cellularity was significantly reduced in the compound kn

294 Proteinuria and renal glomerular cellularity were measured and renal immune complexes wer

295 hage phagocytosis and bronchoalveolar lavage cellularity were not different in P. aeruginosa-infected

296 .77, P = .04), whereas no changes in ADC and cellularity were observed in orthotopic tumors.

297 ice had similar increases in spleen size and cellularity which were statistically significantly highe

298 ed a mildly hypercellular marrow (70% to 80% cellularity), with an elevated myeloid:erythroid ratio o

299 dominantly responsible for diminished spleen cellularity, with fewer memory cells and a failure of ho

300 /-) mice demonstrated enhanced BM and spleen cellularity, with significantly increased numbers of HSC