ライフサイエンスコーパス: centenarian

1 ntal cortex across lifespan, from infancy to centenarian.

2 riers and is enriched in a cohort of healthy centenarians.

3 sal status, or personal or family history of centenarians.

4 90 years and older, including estimates for centenarians.

5 ith a smaller stature in female offspring of centenarians.

6 al studies, clinical studies, and studies of centenarians.

7 arthroplasty are very rarely performed among centenarians.

8 ng selective accumulation of the mutation in centenarians.

9 set consisting of lifelengths of siblings of centenarians.

10 uld target the families of nonagenarians and centenarians.

11 ding for premature mortality in newborns and centenarians.

12 mes the largest previously published GWAS on centenarians.

13 obability of becoming 85- to 94-year-olds or centenarians (100- to 104-year-olds) in 2010 for individ

14 ans and complete cognitive assessment for 72 centenarians (76%).

15 r pollution, exceptional aging, and rates of centenarians: a nationwide analysis of the United States

16 study of exceptional longevity (EL) in 1055 centenarians and 1267 controls.

17 n a second independent cohort of 333 Italian centenarians and 358 geographically matched controls.

18 ng region variants of 53 cognitively healthy centenarians and 45 patients with Alzheimer's disease (A

19 in a population of 450 Ashkenazi Jewish (AJ) centenarians and 550 AJ individuals without a family his

20 gnition parameters were available for all 95 centenarians and complete cognitive assessment for 72 ce

21 L with 77% accuracy in an independent set of centenarians and controls.

22 Family studies of centenarians and long-lived persons have found substanti

23 the 13 bp repeat are highly prevalent among centenarians and overall number of perfect repeats in ma

24 characterized the gut microbiota in Italian centenarians and semi-supercentenarians.

25 levels in sickle cell anemia and a sample of centenarians and show that the approach is highly reprod

26 We demonstrated that centenarians and their offspring maintain longer telomer

27 rved high incidence of the C150T mutation in centenarians and twins.

28 n of rare LoFs in AD subjects as compared to centenarians, and this enrichment is more pronounced for

29 Of the 1023 centenarians approached, 340 were included in the study.

30 Centenarians are a model for healthy aging because they

31 Centenarians are a rapidly growing demographic group wor

32 Generally, it seems that centenarians are asymptomatic or untargeted by cancers.

33 Centenarians are characterized by 2 main features: 1) th

34 small percentage ( approximately 15-25%) of centenarians are functionally cognitively intact.

35 Centenarians are good models for healthy aging studies d

36 Centenarians are more likely to have causes of death cer

37 Centenarians are therefore of scientific interest as a h

38 While centenarian brains revealed varying loads of postmortem

39 ther in silico analysis revealed that 90% of centenarians can be grouped into 19 clusters characteriz

40 blood samples from two regions consisting 76 centenarians (CENs), 54 centenarian-children (F1) and 41

41 egions consisting 76 centenarians (CENs), 54 centenarian-children (F1) and 41 spouses of centenarian-

42 centenarian-children (F1) and 41 spouses of centenarian-children (F1SP) were collected for deep RNA-

43 ng two linked substitutions (N308K/A313S) in centenarians compared with AJ control individuals.

44 Centenarian deaths increased 56% (95% CI 53.8%-57.4%) in

45 The more hypomethylated CpGs observed in the centenarian DNA compared with the neonate covered all ge

46 The centenarian DNA had a lower DNA methylation content and

47 ns, the most hypomethylated sequences in the centenarian DNA were present mainly at CpG-poor promoter

48 ch, human fibroblasts from postnatal to near centenarian donors can be efficiently converted into neu

49 were derived from three middle-aged and four centenarian donors demonstrates that while most of the c

50 Siblings of centenarians experienced a mortality advantage throughou

51 longevity, we analyzed the pedigrees of 444 centenarian families in the United States.

52 urprising insight into the capabilities of a centenarian fish to dramatically respond to a changing e

53 We analyzed 330 centenarians for whom cognitive tests were available at

54 f decedents from a population-based study in centenarians found that zeaxanthin concentrations in bra

55 e bisulfite sequencing (WGBS) of newborn and centenarian genomes.

56 oad between the newborn and the nonagenarian/centenarian groups.

57 Here we present a characterization of the centenarian gut virome using previously published metage

58 lts (>18 yr) and older individuals (>60 yr), centenarians had a more diverse virome including previou

59 We found that centenarians had a significantly lower burden (11-22%) o

60 A fraction of the centenarians had no Abeta load (9 of 95 [9%]), most had

61 Centenarians have a decreased susceptibility to ageing-a

62 Here we show that centenarians have a distinct gut microbiome that is enri

63 The genetics of centenarians have been extensively examined [3], but les

64 The children of centenarians have markedly reduced relative risks for ag

65 ring the aging-related health risks that the centenarians have survived and the developmental risks o

66 of exceptional longevity, usually focused on centenarians, healthy aging is not associated with known

67 Cardiac arrest in nonagenarian and centenarian ICU patients carries high mortality, yet the

68 However, approximately 90% of centenarians in a population-based study were functional

69 rends in place of death and associations for centenarians in England over 10 years to consider policy

70 enditure in octogenarians, nonagenarians and centenarians in the Colombian population, considering ye

71 throplasties and 7 knee arthroplasties among centenarians in this database.

72 ived individuals (LLI) (centenarians or near-centenarians) in 137 sibships and identified statistical

73 e at the end of life requires recognition of centenarians' increased likelihood to "acute" decline, n

74 patients are predicted and observed to reach centenarian lifespan, while in matched non-OA population

75 Interestingly, 5 resilient centenarians maintained high cognitive performance despi

76 ulnerability for decline in memory function, centenarians maintained high levels of performance in al

77 olic output of microbial hydrogen sulfide in centenarians may in turn support mucosal integrity and r

78 ma concentrations are elevated in (close-to-)centenarians (mean +/- SD age 99.5 +/- 4.5 y) commensura

79 This study evaluated Abeta pathology in 95 centenarians (median age at brain donation, 103.5 [IQR,

80 Phage and bacterial members of the centenarian microbiome displayed an increased potential

81 vity using 308 long-lived individuals (LLI) (centenarians or near-centenarians) in 137 sibships and i

82 5- to 94-year-olds (p < 0.001) and 6.4 fewer centenarians (p < 0.001).

83 5- to 94-year-olds (p < 0.001) and 3.5 fewer centenarians (p < 0.05).

84 oon experience twice that prevalence, or one centenarian per 5000 persons.

85 samples ranging from umbilical cord blood to centenarian peripheral blood.

86 gression to evaluate factors associated with centenarians' place of death.

87 y diagnosed, drug-naive) and healthy ageing (centenarians) plus healthy controls, age-matched with Pa

88 terozygous mutations in the IGF1R gene among centenarians relative to controls that are associated wi

89 n of synonymous and intronic mutations among centenarians relative to controls.

90 tein B cell lymphoma-extra large (Bcl-xL) in centenarians relative to octogenarians or younger cohort

91 y has long been studied, and in this regard, centenarians represent a very informative model.

92 Centenarians represent an extreme of life expectancy.

93 n LoF burden originated both from the AD and centenarian sample.

94 e true, it would follow that most if not all centenarians should have Alzheimer's disease.

95 F1 and IGF1 receptor (IGF1R) genes of female centenarians showed overrepresentation of heterozygous m

96 that arthroplasties should not be denied to centenarians solely because of short-term postoperative

97 Notably, a centenarian specific novel variant IGF-1:p.Ile91Leu was

98 The identification of centenarian specimens for breeding based on their potent

99 idemiological, model organism, clinical, and centenarian studies and underline the need to avoid maln

100 Numerous centenarian studies disprove this assumption given that

101 isease Centre, the Nun Study and the Georgia Centenarian Study to obtain a pool of 1110 patients, all

102 data from 3 ongoing studies: the New England Centenarian Study, the Framingham Heart Study, and scree

103 ived from genomes of appropriately consented centenarian subjects.

104 Our analysis found that centenarians survived COVID-19 more than octogenarians a

105 enetic variants associated with longevity in centenarians, the role of the rare loss-of-function (LOF

106 individuals in a cohort of Ashkenazi Jewish centenarians, their offspring, and controls without fami

107 Here, in a cohort of Ashkenazi Jewish centenarians, their offspring, and offspring-matched con

108 c variations in a cohort of Ashkenazi Jewish centenarians, their offspring, and offspring-matched con

109 Centenarians thus have the potential to represent a mode

110 until participation was no longer possible), centenarians underwent an extensive neuropsychological t

111 miology of knee and hip arthroplasties among centenarians using data from a large hospital discharge

112 ial isolates from the faecal microbiota of a centenarian, we identified Odoribacteraceae strains as e

113 with the U.S. 1900 cohort, male siblings of centenarians were at least 17 times as likely to attain

114 Centenarians were compared with patients with clinicopat

115 rtality estimates following arthroplasty for centenarians were higher than for nonagenarians (hazard

116 Centenarians were more likely to die of pneumonia (e.g.,

117 The case histories presented include a centenarian who was a model of healthy aging, a 92-year-

118 correlations thus far suggest that there are centenarians who demonstrate no evidence of neurodegener

119 From January 2013 to July 2022, 1187 centenarians who self-reported being cognitively healthy

120 tmortem neuropathological reports from Dutch centenarians who were drawn from the 100-plus Study betw

121 There also appear to be centenarians who, despite the substantial presence of ne

122 ably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants

123 These pedigrees included 2,092 siblings of centenarians, whose survival was compared with 1900 birt

124 lesions, a cognitively and physically intact centenarian with almost no neuropathology, and an 85-yea

125 enal disease, but there are also examples of centenarians with adequate renal function.

126 gnificantly less tau pathology compared with centenarians with high Abeta loads and low cognitive per

127 nificantly higher cognitive performance than centenarians with high Abeta loads.

128 Centenarians with no or low Abeta load had significantly

129 n this large population of nonagenarians and centenarians with NSTE-ACS, increasing adherence to guid

130 fied 35 genes with depleted LOF mutations in centenarians, with 14 of these validated in the UK Bioba

131 If this were true, most if not all centenarians would have significant disability.