ライフサイエンスコーパス: central nervous system

1 tides and phosphor-tau, respectively, in the central nervous system.

2 ral anatomical features of the whip spiders' central nervous system.

3 the development of autoimmune disease in the central nervous system.

4 tly needed, given their critical role in the central nervous system.

5 by lymphocytes in autoimmune diseases of the central nervous system.

6 cal regulators of electrical activity in the central nervous system.

7 directly affecting neuronal activity in the central nervous system.

8 attack of inflammatory demyelination of the central nervous system.

9 be PNNs, surrounding neurons throughout the central nervous system.

10 xon 7 inclusion, but less persistence in the central nervous system.

11 n several pathologies including those of the central nervous system.

12 cytes are fundamental building blocks of the central nervous system.

13 isease characterized by demyelination in the central nervous system.

14 y which long-term memories are stored in the central nervous system.

15 ne inflammatory demyelinating disease of the central nervous system.

16 l signaling pathways arising from the tick's central nervous system.

17 lated to neurogenesis and development of the central nervous system.

18 e of GFAP in blood severely affect the human central nervous system.

19 mote regeneration both in the peripheral and central nervous system.

20 nding of the physiology and pathology of our central nervous system.

21 euticals with therapeutic effects within the central nervous system.

22 signing and executing experiments within the central nervous system.

23 ary and in shaping neuronal functions in the central nervous system.

24 cells are converted into progenitors of the central nervous system.

25 cipal form of contact between neurons of the central nervous system.

26 channel THIK-1 is strongly expressed in the central nervous system.

27 potential to modify TSPO levels in the adult central nervous system.

28 ALL and in the migration of ALL cells to the central nervous system.

29 FF (NPFF) is well-known for its roles in the central nervous system.

30 are homeostatic and protective cells of the central nervous system.

31 ion profiles among various cell types of the central nervous system.

32 ylation is the main metabolic pathway in the central nervous system.

33 nents in mediating regeneration in the adult central nervous system.

34 gh which Nogo-A may exert its effects in the central nervous system.

35 in motor control and pain processing in the central nervous system.

36 eceptors (NMDARs) play critical roles in the central nervous system.

37 ix patients showed metastatic disease in the central nervous system.

38 nes involved in the early development of the central nervous system.

39 eric modulator of ion channels found in host central nervous systems.

40 d nociceptive pathways in the peripheral and central nervous systems.

41 fast excitatory responses in peripheral and central nervous systems.

42 in saliva, urine, semen, breast milk and the central nervous system(8-12).

43 myelitis, 0.5 to 0.9 per 100 000 persons for central nervous system abscesses, and 24.4 to 32.9 per 1

44 Transcriptomes from the central nervous system across a time series during diapa

45 erve an additional important function in the central nervous system: acting as a sensory network, the

46 cross the blood-brain barrier and enter the central nervous system, activating neuroinflammatory res

47 neural and endocrine pathways, by which the central nervous system adjusts cardiac output and periph

48 They include genes involved in the central nervous system-adrenal signaling axis (ZDHHC17,

49 ven that peripheral monocytes repopulate the central nervous system after CSF1R inhibition, these cha

50 nisms by which the immune system affects the central nervous system after surgical trauma.

51 e biomarker is released immediately from the central nervous system after TBI.

52 Beyond the central nervous system, alpha5-containing GABA(A) recept

53 ed interleukin-1 (IL-1) signaling within the central nervous system and are mediated by IL-1 receptor

54 They are found within the central nervous system and are responsible for fast upta

55 Astrocytes tile the central nervous system and are widely implicated in brai

56 an kinesin-2 that is highly expressed in the central nervous system and associated with vesicles in n

57 erstanding the role of SGK1 signaling in the central nervous system and evaluating SGK1 as a potentia

58 the modulation of synaptic responses in the central nervous system and have been implicated in neuro

59 ell bodies of a subset of the neurons in the central nervous system and play key roles in both develo

60 smit pain signals from the peripheral to the central nervous system and that exerts its effects on ne

61 directional communication system between the central nervous system and the gastrointestinal tract, e

62 hibit important biological activities in the central nervous system and the peripheral nervous system

63 e of the WHO Classification of Tumors of the Central Nervous System and the subsequent recommendation

64 activates cytoplasmic lipid synthesis in the central nervous system and thereby supports neuronal dif

65 eceptors mediate transmission throughout the central nervous system and typically contain a delta sub

66 1 tissue reservoirs, with an emphasis on the central nervous system, and describe relevant new work i

67 t for the development and homeostasis of the central nervous system, and its disruption has been link

68 nfection has the potential for targeting the central nervous system, and several neurological symptom

69 mechanisms affecting the development of the central nervous system are poorly understood.

70 lar RNAs (circRNAs), highly expressed in the central nervous system, are involved in various regulato

71 he activation of different structures of the central nervous system, as compared to rodents.

72 gammadelta17 T cells, we defined the nearest central nervous system-associated source of IL-17a under

73 meningeal IgA is essential for defending the central nervous system at this vulnerable venous barrier

74 i35-Bregs suppress central nervous system autoimmune diseases by inducing i

75 Adult mammalian central nervous system axons have intrinsically poor reg

76 Central nervous system B cells have several potential ro

77 t only causes addiction behavior through the central nervous system, but also modulates the periphera

78 axonal regeneration following injury to the central nervous system, but the mechanism by which the m

79 naptic excitatory signaling in the mammalian central nervous system by forming calcium-permeable tran

80 Inflammation in the central nervous system can be triggered by a variety of

81 e most effective interventions for adult non-central nervous system cancer patients to manage cancer-

82 ts following cranial radiotherapy to control central nervous system cancers.

83 ease (VWM) is a severe leukodystrophy of the central nervous system caused by mutations in subunits o

84 phalopathy is a demyelinating disease of the central nervous system caused by the reactivation of the

85 rotein isoforms that are highly expressed in central nervous system cells.

86 NA-binding protein of 43 kDa (TDP-43) in the central nervous system characterizes frontotemporal deme

87 In the central nervous system, CLC-2 appears in neurons and gli

88 Here we present a flatmap of the mouse central nervous system (CNS) (brain) and substantially e

89 n had a prior opportunistic infection of the central nervous system (CNS) (odds ratio [OR], 3.7; P <

90 In the nilotinib group, central nervous system (CNS) amyloid burden was signific

91 and function of the immune system within the central nervous system (CNS) and altered the paradigm fo

92 Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the

93 viruses infect the respiratory tract and the central nervous system (CNS) and can be highly infectiou

94 uantitative analyses of CAG expansion in ~50 central nervous system (CNS) and peripheral postmortem t

95 ly through the autonomic pathway to both the central nervous system (CNS) and the autonomic innervati

96 icated in modulating immune responses in the central nervous system (CNS) and the periphery.

97 isplay a wide range of phenotypes though the central nervous system (CNS) appears to be the most comm

98 HIV-1 reservoirs in the central nervous system (CNS) are challenging to address

99 ozen, archived tissue samples from the human central nervous system (CNS) are currently available in

100 a neuroendocrine hormone synthetized in the central nervous system (CNS) as well as enterochromaffin

101 s are associated with a group of ill-defined central nervous system (CNS) autoimmune diseases termed

102 The central nervous system (CNS) barriers are crucial interf

103 Central nervous system (CNS) blood vessels contain a fun

104 In addition, we discuss how central nervous system (CNS) degeneration might interact

105 Healthy central nervous system (CNS) development and function re

106 -1/DCC ligand/receptor pair has key roles in central nervous system (CNS) development, mediating axon

107 ver of disability and disease progression in central nervous system (CNS) diseases such as amyotrophi

108 ting polyneuropathy (AIDP) type of GBS or in central nervous system (CNS) diseases.

109 d molecular mechanisms in cardiovascular and central nervous system (CNS) diseases.

110 terize various cellular functions, and model central nervous system (CNS) diseases.

111 Recent discoveries of their involvement in central nervous system (CNS) disorders, and in particula

112 conventional drugs impedes the treatment of central nervous system (CNS) disorders.

113 The natural history of non-central nervous system (CNS) disseminated coccidioidomyc

114 rse genetic programs that assemble the human central nervous system (CNS) during development and main

115 y and depression (HAD) as a proxy measure of central nervous system (CNS) dysfunction, were assessed.

116 The central nervous system (CNS) encompasses the brain and s

117 Our data suggest the central nervous system (CNS) endothelium as a target to

118 Loss of central nervous system (CNS) FAO did not result in gross

119 to limit virus dissemination throughout the central nervous system (CNS) following many neurotropic

120 are used as biomarkers for the management of central nervous system (CNS) germ cell tumors (GCTs).

121 Inflammation in the central nervous system (CNS) has been linked to demyelin

122 hip between the innate immune system and the central nervous system (CNS) has moved to the forefront

123 The adult human central nervous system (CNS) has very limited regenerati

124 ow that the AIM2 inflammasome contributes to central nervous system (CNS) homeostasis specifically th

125 Disease involved the central nervous system (CNS) in 71 subjects (49%).

126 To study the role of myeloid cells in the central nervous system (CNS) in the pathogenesis of mult

127 the therapeutic value of mTOR inhibitors for central nervous system (CNS) indications.

128 Inflammation of the central nervous system (CNS) induces endothelial blood-b

129 rechovirus (PeV) are leading viral causes of central nervous system (CNS) infection among hospitalize

130 Central nervous system (CNS) infections cause substantia

131 r punctures (LPs) in patients with suspected central nervous system (CNS) infections has been associa

132 Central nervous system (CNS) injuries are often debilita

133 e actions of IL-33 in experimental models of central nervous system (CNS) injury, we predicted that c

134 However, the transcriptomic landscape of central nervous system (CNS) innate immune cells contrib

135 The central nervous system (CNS) is a likely reservoir of HI

136 Leukocyte entry into the central nervous system (CNS) is essential for immune sur

137 The central nervous system (CNS) is vulnerable to viral infe

138 Over time, the central nervous system (CNS) loses function and regenera

139 tion-derived monocytes, other non-microglial central nervous system (CNS) macrophage subtypes include

140 lae following clinical radiotherapy (RT) for central nervous system (CNS) malignancies are often long

141 HR) DNA repair-proficient cancers, including central nervous system (CNS) malignancies.

142 CCN3 is therefore a candidate of interest in central nervous system (CNS) myelination and remyelinati

143 Central nervous system (CNS) neurodegeneration is define

144 abdoid tumors (ATRTs) typically arise in the central nervous system (CNS) of children under 3 years o

145 tion of neurons expressing PSST mRNAs in the central nervous system (CNS) of Scyliorhinus canicula us

146 I and II IFNs control MuPyV infection in non-central nervous system (CNS) organs, but their relative

147 d-to-binary conversion is implemented in the central nervous system (CNS) remains poorly understood.

148 Microglia, the innate immune cells of the central nervous system (CNS) survey their surroundings w

149 n barrier is a major impediment for targeted central nervous system (CNS) therapeutics, especially wi

150 ehavior in metazoans, but how they enter the central nervous system (CNS) through the blood-brain bar

151 efferent neurons carry information from the central nervous system (CNS) to peripheral targets.

152 ternative therapeutic approach for targeting central nervous system (CNS) tumors and the constituency

153 l fluid (CSF) flow dynamics in children with central nervous system (CNS) tumors before intraventricu

154 Injury to the adult central nervous system (CNS) usually leads to permanent

155 lar endothelial cells (ECs) derived from the central nervous system (CNS) variably lose their unique

156 major inhibitory neurotransmitter within the central nervous system (CNS) with fast, transsynaptic, a

157 to prevent inflammatory tissue damage in the central nervous system (CNS), and none directly promote

158 ulable states, direct virus infection of the central nervous system (CNS), and postinfectious immune

159 manifold roles that these cells play in the central nervous system (CNS), and this work has been gre

160 The central nervous system (CNS), consisting of the brain, s

161 e with high cellular complexity, such as the central nervous system (CNS), it is difficult to attribu

162 cytes are the most abundant cell type in the central nervous system (CNS), performing complex functio

163 ed axons typically fail to regenerate in the central nervous system (CNS), resulting in chronic neuro

164 ly suggested to be present in the cephalopod central nervous system (CNS), Scaros, Croll, and Baratte

165 ic inflammatory demyelinating disease of the central nervous system (CNS), the aetiology of which is

166 om published studies on ex vivo ECs from the central nervous system (CNS), we predicted TFs that indu

167 Neurovascular pathologies of the central nervous system (CNS), which are associated with

168 (MS) is a chronic autoimmune disease of the central nervous system (CNS), with characteristic inflam

169 Microglia and central nervous system (CNS)-associated macrophages (CAM

170 tional knock out (het CKO) murine model with central nervous system (CNS)-specific Nestin-Cre drivers

171 nt HIV reservoirs in vivo, especially in the central nervous system (CNS).

172 ally or highly expressed by microglia in the central nervous system (CNS).

173 o the architecture and the physiology of the central nervous system (CNS).

174 o effect on the vasculature elsewhere in the central nervous system (CNS).

175 parenchymal cells that ubiquitously tile the central nervous system (CNS).

176 pal phagocytes that clear cell debris in the central nervous system (CNS).

177 atory diseases, and encephalomyelitis in the central nervous system (CNS).

178 luid is directionally transported within the central nervous system (CNS).

179 dinium cation hampers uptake of OPs into the central nervous system (CNS).

180 n microglia, the resident macrophages of the central nervous system (CNS).

181 could be sites of HSV-1 reactivation in the central nervous system (CNS).

182 ons have spatial preference in the mammalian central nervous system (CNS).

183 disease in response to JHMV infection of the central nervous system (CNS).

184 d behavior, both peripherally and within the central nervous system (CNS).

185 the peripheral nervous system (PNS) and the central nervous system (CNS).

186 r injury and during axon regeneration in the central nervous system (CNS).

187 hat alter the tissue microenvironment of the central nervous system (CNS).

188 ed axons and irreversible destruction of the central nervous system (CNS).

189 ft-versus-host disease (GVHD) can affect the central nervous system (CNS).

190 promise for therapeutic applications in the central nervous system (CNS).

191 ays a key role in synaptic plasticity in the central nervous system (CNS).

192 those occurring in the persistently inflamed central nervous system (CNS).

193 gent of a fatal demyelinating disease of the central nervous system (CNS).

194 roglia are the resident myeloid cells in the central nervous system (CNS).

195 trocyte interactions with other cells in the central nervous system (CNS).

196 ortant in development and pathologies of the Central Nervous System (CNS); however, their coordinatin

197 ), (2) BMICNS (54 loci near genes related to central nervous system [CNS]), and (3) BMInon-CNS (43 lo

198 DHA is a key central nervous system constituent and the precursor of

199 broad tissue types present in metazoans, the central nervous system contains some of the highest leve

200 at a level below 1 nM, may lead to liver and central nervous system damages in humans and animals, wh

201 AVrh.10 and AAVrh.39, a feature utilized for central nervous system delivery of therapeutic genes.

202 ltration of peripheral immune cells into the central nervous system, demyelination, and neuronal dama

203 works in stratified tissues of the mammalian central nervous system depends upon the proper migration

204 ease including corneal opacities, multifocal central nervous system disease and progressively worseni

205 Although Alzheimer's disease (AD) is a central nervous system disease and type 2 diabetes MELLI

206 Beyond its effects in the central nervous system, disease-associated mutant HTT ca

207 Moreover, patients with central nervous system disorders associated to neuroimmu

208 tified as a promising therapeutic target for central nervous system disorders including schizophrenia

209 logies, including cardiovascular disease and central nervous system disorders, as well as various for

210 of novel therapies for clinically important central nervous system disorders.

211 ntial of 1-propargyl-4-styrylpiperidines for central nervous system disorders.

212 emely useful for in vivo characterization of central nervous system drug candidates, neurodegenerativ

213 t, the B cell phenotypes that infiltrate the central nervous system during human immunodeficiency vir

214 Microglia, the resident immune cells of the central nervous system, engulf surplus neurons and synap

215 y neutrophils, which accumulated at a unique central nervous system entry portal called the velum int

216 ignals will be important to fully understand central nervous system formation, health, and function.

217 n the context of an evolutionary mismatch of central nervous system functions.

218 ng the lungs, cardiovascular system, kidney, central nervous system, gastrointestinal tract, and skin

219 partially shared between the peripheral and central nervous system glia, indicating common immunolog

220 In the central nervous system, glycogen-derived bioenergetic re

221 In the vertebrate central nervous system, groups of functionally related n

222 The central nervous system has historically been viewed as a

223 n the numerous cell types and regions of the central nervous system, has been difficult to study due

224 K(ATP) channels in the central nervous system have been shown to regulate EGP i

225 up I metabotropic glutamate receptors in the central nervous system have not been studied in detail.

226 ascular segments of endothelial cells in the central nervous system, have abundant caveolae.

227 ytes, a major cell type found throughout the central nervous system, have general roles in the modula

228 The central nervous system hosts parenchymal macrophages, kn

229 g EIF2B proteins cause childhood ataxia with central nervous system hypomyelination/vanishing white m

230 by more past opportunistic infections of the central nervous system, imperfect adherence to antiretro

231 occur without hearing loss, implicating the central nervous system in the generation of hyperacusis.

232 Stroke patients with small central nervous system infarcts often demonstrate an acu

233 (Tr1 cells), concomitant with a reduction in central nervous system-infiltrating effector T cells (Te

234 B supplementation in modulating systemic and central nervous system inflammation as well as promoting

235 ty that limits functional repair following a central nervous system injury remains a challenge.

236 elop hepatitis, coagulopathy, liver failure, central nervous system involvement, multiorgan failure,

237 aled that these receptors' expression in the central nervous system is crucial for T cell recruitment

238 illance against pathogens and tumours in the central nervous system is thought to be limited owing to

239 er to liver, heart, skeletal muscle, and the central nervous system, its use in adipose tissue has be

240 In the central nervous system, ketamine acts primarily by block

241 cohort to provide a detailed description of central nervous system lesions in Leigh syndrome and the

242 the BSN gene exert its effect on CAD through central nervous system-lifestyle risk factors.

243 her common extranodal sites, including skin, central nervous system, liver, and kidneys.

244 s with acute-onset terminal disease, whereas central nervous system localization was seen in animals

245 In the central nervous system, lower motor neurons are selectiv

246 Microglia are resident central nervous system macrophages and the first respond

247 osus (SLE) experience various peripheral and central nervous system manifestations including spatial

248 ry role in cancer progression, especially in central nervous system metastases.

249 ts demonstrated ocular disease that preceded central nervous system metastasis.

250 d cells that transcriptionally differed from central nervous system microglia.

251 One of the tissues of the central nervous system most affected by diabetes is the

252 The aGPCR GPR56/ADGRG1 regulates central nervous system myelination and melanoma progress

253 Central nervous system-native myeloid cells (CNS-myeloid

254 in, an antigen in the outer myelin sheath of central nervous system neurons, are present.

255 in36 (Cx36) is the most abundant connexin in central nervous system neurons.

256 In several areas of the central nervous system, neurons are regionally organized

257 of the tunicate Ciona intestinalis possess a central nervous system of 177 neurons.

258 iled distribution of Pax6 cells in the adult central nervous system of lungfishes, the closest living

259 increase in TDP-43(A315T) expression in the central nervous system of mature mice resulted in progre

260 of RNA from individual cell clusters in the central nervous system of the marine mollusk Aplysia cal

261 evere cases (HDIVig refractory or cases with central nervous system or cardiac involvement).

262 ereas bone (P < .0001), lung (P = .002), and central nervous system (P = .03) infections were more co

263 cal block of P2X7Rs primarily outside of the central nervous system parenchyma, recapitulates the ben

264 ntial to become drug candidates for distinct central nervous system pathologies and possessing accent

265 as a neurotransmitter/neuromodulator of many central nervous system processes such as learning and me

266 ap spatial transcriptomic analysis and whole-central nervous system projection tracing, we identified

267 Cyclophosphamide, systemic cytarabine, and central nervous system radiotherapy were not used.

268 Elevated Protrudin expression enabled robust central nervous system regeneration both in vitro in pri

269 observation, it is currently unknown how the central nervous system regulates motor unit behaviour in

270 l PET imaging ligand for mGluR2 in different central nervous system-related conditions.

271 nsported in neurons, especially those of the central nervous system, remains unclear.

272 patients who present with ongoing viremia or central nervous system replication.

273 altered phenotype in key compartments of the central nervous system responsible for regulating feedin

274 y limited when the tumour is confined to the central nervous system, resulting in uncontrolled tumour

275 Surprisingly, the central nervous system-specific conditional deletion of

276 sensory nerve pathway between the colon and central nervous system (spinal cord and brain) that unde

277 Hospitalizations for endocarditis, central nervous system/spine infections, osteomyelitis,

278 d Capn15 expression throughout the brain and central nervous system, strongest during early developme

279 beta1 spectrin has no discernable effect on central nervous system structure or function.

280 alpha-syn has acute systemic effects on the central nervous system such that structural and resting-

281 astrocytic processes are an integral part of central nervous system synapses(1,2); however, the molec

282 The internalization of the central nervous system, termed neurulation in vertebrate

283 tures within the extracellular matrix of the central nervous system that have generated an explosion

284 e essential ligand-gated ion channels in the central nervous system that mediate excitatory synaptic

285 s and relay this information to areas of the central nervous system that, in turn, regulate gut physi

286 target organs: disseminated skin sites, the central nervous system, the heart and large joints.

287 Importantly in the central nervous system, their activation promotes axon r

288 though CD4 T cells have been reported in the central nervous system, their presence in the healthy br

289 Although long-studied in the central nervous system, there is increasing evidence tha

290 In the central nervous system, this plasticity stems from oligo

291 l cells that actively relay signals from the central nervous system to SMCs via a caveolae-dependent

292 tion and functional recovery after mammalian central nervous system trauma, including spinal cord inj

293 Malignant gliomas are central nervous system tumors and remain among the most

294 Ependymomas are aggressive central nervous system tumors that resist chemotherapy.

295 Ependymoma is a heterogeneous entity of central nervous system tumors with well-established mole

296 sarcoma, melanomas, and radiotherapy-related central nervous system tumors, which are associated with

297 clearing amyloid and tau pathology from the central nervous system, we hypothesized that cholinergic

298 rther enhance the therapeutic affects to the central nervous system, we systemically delivered an ade

299 tor cells, a daunting task in the developing central nervous system where thousands of cell types are

300 erve into the corresponding neuromere of the central nervous system, where they terminate on a partic