1 nt of a perfectly unique cell type remains a
central question.
2 ens involved in triggering this process is a
central question.
3 eneficial and evolutionarily successful is a
central question.
4 ype productively infected by MCPyV remains a
central question.
5 nization regulates gene expression remains a
central question.
6 research in experimental philosophy on four
central questions.
7 new millennium poised to answer many of its
central questions.
8 te NMR spectroscopy is used to address these
central questions.
9 principles, which collectively address four
central questions: (
a) What is a relationship?
10 Presently, the
central question about caspase-6 structure and function
11 A
central question about human brain aging is whether cogn
12 A
central question about the brain is how information is p
13 A
central question about the role of Abeta in disease conc
14 A
central question about the role of alphaS in the pathoge
15 A
central question about the Wnt pathway is the regulation
16 One of the most
central questions about the repair of a double-strand DN
17 To address this
central question and to define the molecular and cellula
18 The origin of species remains a
central question,
and recent research focuses on the rol
19 The
central questions are how to achieve protective antibody
20 Central questions are to determine which cells among pro
21 A
central question arising from these observations is whet
22 ggregates populate the meninges, raising the
central question as to whether these structures relate t
23 The
central questions asked in whole-genome association stud
24 best represented as dimensions or spectra, a
central question becomes how to implement dimensional di
25 ingle target grammar and one PLD source, the
central question being whether the target grammar can be
26 The microscopic motion of water is a
central question,
but gaining experimental information a
27 A
central question concerning COVID-19 is why some individ
28 A
central question concerns the conditions that produce th
29 A
central question concerns the mechanism of microfibril s
30 A
central question concerns the morphology of the last com
31 ices are available for a given amino acid, a
central question concerns whether viral sequences have e
32 A
central question concerns which hematopoietic stem and p
33 One
central question critical to device performance is how t
34 sh in this harsh environment by addressing a
central question:
did exposure to hypoxia drive adaptati
35 plasticity mechanisms in the brain raises a
central question:
does a neural circuit store all memori
36 One
central question for ACHRE was to determine what role, i
37 specific transcriptional programs remains a
central question for all eukaryotes.
38 A
central question for all LacI family proteins concerns t
39 on from multiple upstream regions has been a
central question for decades.
40 these different responses are regulated is a
central question for developmental biology.
41 A
central question for neuroscience is how to characterize
42 A
central question for regenerative neuroscience is whethe
43 Formation of the fusion pore is a
central question for regulated exocytosis by which secre
44 A
central question for self-organizing swarms interacting
45 A
central question for spatio-temporal dynamics is the rel
46 ous assembly of microscale compartments is a
central question for the origin of life, and has technol
47 The present work investigates this
central question for the prototype Ir(1,5-COD)Cl/gamma-A
48 Therefore, a
central question for the structural biology of IFs is wh
49 A
central question for the theory is to determine conditio
50 positioning of the centrosome are unknown, a
central question given the role of cilia in fluid propul
51 A
central question has been how GVHD is sustained despite
52 ddition to the scientific issues at stake, a
central question has been how scientists can maintain th
53 g examples of current studies that address a
central question:
How do neural stem cells (NSCs) divide
54 rchers led by John Gurdon interrogated three
central questions:
how are cell type-specific programs g
55 A
central question important to understanding DNA repair i
56 A
central question in Alzheimer's disease (AD) is the role
57 A
central question in Alzheimer's Disease (AD) is whether
58 A
central question in Alzheimer's disease (AD) research is
59 A
central question in Alzheimer's disease concerns the mec
60 A
central question in Alzheimer's disease research is what
61 A
central question in animal evolution is how multicellula
62 A
central question in bacterial ecology is whether species
63 A
central question in biology is how genes control the exp
64 A
central question in biology is how RNA sequence changes
65 A
central question in biology is how spatial information i
66 e their enormous rate enhancements remains a
central question in biology, and our understanding to da
67 Although it is a
central question in biology, how cell shape controls int
68 from combinatorial expression of genes is a
central question in biology.
69 es the stabilization of such assemblies is a
central question in biology.
70 A
central question in both diseases is how the loss of cel
71 A
central question in cancer biology is whether malignancy
72 A
central question in cancer biology is why most tumor sus
73 petence to colonize distant organs remains a
central question in cancer biology.
74 with approximate phenotypic equivalency is a
central question in cancer biology.
75 A
central question in cancer immunology is whether recogni
76 A
central question in cancer therapy is how individual cel
77 A
central question in cell biology is how cells determine
78 A
central question in cell biology is how cells respond to
79 A
central question in cell biology is how the identity of
80 igenetic marks and gene regulation remains a
central question in chromatin biology.
81 A
central question in cognitive neuroscience concerns the
82 A
central question in cognitive neuroscience is whether me
83 A
central question in cognitive neuroscience regards the m
84 o memory while other information is not is a
central question in cognitive neuroscience.
85 A
central question in community ecology is the means by wh
86 egulatory landscape of the human genome is a
central question in complex trait genetics.
87 A
central question in consciousness theories is whether on
88 A
central question in development is to define how the equ
89 basis of morphological complexity remains a
central question in developmental and evolutionary biolo
90 A
central question in developmental biology is how embryon
91 nance and differentiation of stem cells is a
central question in developmental biology.
92 cular basis of Wnt-Frizzled specificity is a
central question in developmental biology.
93 enetic divergence and genetic structure is a
central question in ecology and evolution.
94 A
central question in ecology is why alien species natural
95 A
central question in ecology with great importance for ma
96 ly and stability of complex communities is a
central question in ecology.
97 sms that determine biological diversity is a
central question in ecology.
98 tability or predictability of evolution is a
central question in evolutionary biology and most often
99 A
central question in evolutionary biology is what drives
100 A
central question in evolutionary biology is whether spon
101 s by which new protein functions evolve is a
central question in evolutionary biology, biochemistry,
102 basis of adaptation to the environment is a
central question in evolutionary biology, yet linking de
103 The emergence of cooperation is a
central question in evolutionary biology.
104 The evolutionary cost of gene loss is a
central question in genetics and has been investigated i
105 equencies contribute to trait variation is a
central question in genetics.
106 A
central question in glioblastoma multiforme (GBM) resear
107 A
central question in gustatory research is how informatio
108 A
central question in Hedgehog (Hh) signaling is how evolu
109 A
central question in hematopoiesis is how cell-cycling be
110 A
central question in histone code theory is how various c
111 Therefore, a
central question in immunology is how the naive T cell p
112 A
central question in immunology is the origin of long-liv
113 A
central question in immunology is what features allow th
114 A
central question in insect chemoreception is whether sig
115 A
central question in iron-based superconductivity is the
116 etabolic cues from the environment remains a
central question in kidney research.
117 A
central question in lignin biosynthesis is how guaiacyl
118 ne repression to gene activation represent a
central question in mammalian development.
119 n gene activation and repression events is a
central question in mammalian organogenesis, as exemplif
120 to emergence of specific cell types remain a
central question in mammalian organogenesis.
121 he mechanism of Bax/Bak activation remains a
central question in mitochondria-dependent apoptotic sig
122 For over 30 years a
central question in molecular evolution has been whether
123 otein and regulatory sequence evolution is a
central question in molecular evolution.
124 d mode of protein evolution continue to be a
central question in molecular evolution.
125 sive stage occurs and how to prevent it is a
central question in MS.
126 A
central question in muscle biology is how costameres are
127 A
central question in myelin biology is the extent to whic
128 r state in metal nanoparticles constitutes a
central question in nanoscience research because of its
129 nanoparticles with increasing size remains a
central question in nanoscience.
130 preaders that maximize information flow is a
central question in network theory.
131 A
central question in neural development is how the broad
132 rons make specific synaptic connections is a
central question in neurobiology.
133 r the long distance to the channel remains a
central question in neurobiology.
134 A
central question in neuroscience is how context changes
135 A
central question in neuroscience is how interactions bet
136 A
central question in neuroscience is how self-organizing
137 A
central question in neuroscience is how synaptic plastic
138 A
central question in neuroscience is how the organization
139 llular compartments.SIGNIFICANCE STATEMENT A
central question in neuroscience is the complex relation
140 A
central question in neuroscience is to understand how no
141 asites with wide host ranges can evolve is a
central question in parasite evolution.
142 tem cell perpetuation and organogenesis is a
central question in plant biology.
143 to various environmental perturbations is a
central question in plant biology.
144 cytokinesis in the embryo and endosperm is a
central question in plant reproductive biology.
145 A
central question in population ecology is the role of 'e
146 A
central question in protein evolution is the extent to w
147 A
central question in protein-DNA recognition is the origi
148 ypes to modulate organismal traits remains a
central question in quantitative genetics.
149 A
central question in reverse engineering of genetic netwo
150 producible patterns with high precision is a
central question in science.
151 ated by their microenvironment or niche is a
central question in stem cell and regenerative biology.
152 A
central question in stem cell biology is whether organ h
153 nd differentiation of neural stem cells is a
central question in stem cell biology.
154 A
central question in stem cell research is how stem cells
155 s the organization of the transcriptome is a
central question in systems genetics.
156 ehavior to resting-state brain function is a
central question in systems neuroscience.
157 A
central question in telomerase function is how transloca
158 A
central question in the area of signal transduction is w
159 A
central question in the field concerns the relationship
160 A
central question in the field is to understand how diffe
161 nd integrated with pre-existing tissues is a
central question in the field of regeneration.
162 orce gates mechanotransduction channels is a
central question in the field, for which there are two m
163 via the PDF receptor (PDFR) occurs is now a
central question in the field.
164 ale signals and female preferences remains a
central question in the study of animal communication.
165 A
central question in the study of cell proliferation is,
166 A
central question in the study of vapour-deposited glasse
167 cause requirements for HAT complexes vary, a
central question in transcriptional regulation is how di
168 This is a
central question in translational neuroscience that is p
169 A
central question in understanding the mechanism of integ
170 A
central question in urban ecology is why some species ad
171 A
central question in vascular biology is the role of the
172 A
central question in visual neuroscience is what circuits
173 A
central question in Wnt signaling is the regulation of b
174 e scales for regulation of this response are
central questions in biochemistry.
175 e over the course of disease and therapy are
central questions in cancer biology.
176 The
central questions in common AD focus on whether cerebral
177 ific cells are selected to die is one of the
central questions in development.
178 One of the
central questions in developmental biology is that of ho
179 nism of protein sequence evolution have been
central questions in evolutionary biology since the 1960
180 such regions form and how they evolve remain
central questions in evolutionary genetics.
181 superconducting gap above T(c) is one of the
central questions in high-T(c) research.
182 One of the
central questions in neurobiology is how experience modi
183 One of the
central questions in neuroscience is how particular task
184 interventions, or genetic manipulations are
central questions in neuroscience.
185 lates of learning has constituted one of the
central questions in neuroscience.
186 selectivity during extinction events remain
central questions in palaeobiology.
187 logical selectivity at extinction events are
central questions in palaeobiology.
188 s and the nature of taxonomic radiations are
central questions in paleobiology.
189 Differences in gene expression underlie
central questions in plant biology extending from gene f
190 ore, and use this information to investigate
central questions in prion biology.
191 s identity and mechanism of operation remain
central questions in sensory neuroscience.
192 Two
central questions in signaling are the mechanism of acti
193 ir proliferation and differentiation are two
central questions in stem cell biology.
194 One of the
central questions in the biophysics of the mammalian coc
195 how these may affect population dynamics are
central questions in the field of animal migration [1] t
196 One of the
central questions in the field of Ras biology is how the
197 Here we review
central questions in their performance as free energy tr
198 easure of insect cold tolerance used to test
central questions in thermal biology and predict the eff
199 A
central question is how direct photochemical electron de
200 A
central question is how EGFR transits vectorially from e
201 A
central question is how eukaryotic ribosomes transition
202 A
central question is how members of this microbiota sense
203 A
central question is how nuclear substrates gain access t
204 A
central question is how specificity in cellular response
205 4-bp Smad binding elements (SBEs) in DNA, a
central question is how specificity of TGF-beta-induced
206 A
central question is how the balance between these two op
207 A
central question is how the motor system adapts in respo
208 One
central question is how the TRAMP complex, especially th
209 A
central question is how the X chromosome is recognized.
210 A
central question is how various stages of neuronal devel
211 The
central question is not whether performance on cognitive
212 A
central question is the biochemical mechanisms that make
213 of both TRPC and Orai1 channels by STIM1, a
central question is the role of each of the channels in
214 A
central question is thus how Xer/dif recombination is tu
215 A
central question is to what degree these coreceptors fun
216 A
central question is what kind of information controls th
217 A
central question is whether Abeta plays a direct role in
218 A
central question is whether and how DNA translocation is
219 A
central question is whether and how these flanking regio
220 A
central question is whether aneuploid phenotypes are the
221 In all cases, a
central question is whether crystallization pressure wil
222 A
central question is whether multiple objects can be prio
223 A
central question is whether mutualisms persist because h
224 The
central question is whether phenotype heterogeneity, suc
225 A
central question is whether PPARgamma binding in macroph
226 The
central question is whether the rhythm is generated by a
227 Another
central question is whether these proteins act as genera
228 A
central question is, how are signals emanating from mult
229 A
central question is, therefore, how should a policymaker
230 A
central question is: does TRF function in vivo to transd
231 A
central question is: Why would cells mate with themselve
232 ence Standards (NGSS) and focused around the
central question of "Who am I?" Campers approached this
233 ongoing behavior for performance errors is a
central question of cognitive neuroscience.
234 A
central question of dynamics, largely open in the quantu
235 ult weakening during accelerated slip, and a
central question of earthquake physics is identifying th
236 tions that undergo sexual recombination is a
central question of epidemiology with profound implicati
237 y without treatment for many years remains a
central question of HIV research.
238 However, the
central question of how iNKT cells are activated by micr
239 tionship between them and contributes to the
central question of how language evolves.
240 However, the
central question of how these sugars are perceived in th
241 manner.SIGNIFICANCE STATEMENT We address the
central question of how to comprehensively define molecu
242 A
central question of marine ecology is, how far do larvae
243 tive understanding of human behaviour into a
central question of modern science.
244 ing mechanical imbalances are generated is a
central question of morphogenesis, with existing paradig
245 How the nervous system is wired has been a
central question of neuroscience since the inception of
246 erned cellular identities are generated is a
central question of organogenesis.
247 A
central question of paramount importance is how structur
248 gy) and function of biological networks is a
central question of systems biology.
249 To address the
central question of the sequential control of these two
250 s of direction selectivity for 60 years, the
central question of their underlying algorithm remains u
251 The
central question of this review is whether these 2D phas
252 ar receptors for a single antigen raised the
central question of where B lymphocytes encounter antige
253 Additionally, within the glomerulus, the
central question of whether the primary filtration barri
254 infancy, yet evidence is conflicting on the
central question of whether visual experience with faces
255 However, the
central question of why it took these populations approx
256 The
central questions of bacterial ecology and evolution req
257 Here we address the
central questions of how stable isotropic growth of a br
258 and explaining this diversity is one of the
central questions of human biology.
259 es and maintain diversity remains one of the
central questions of microbiology, requiring an understa
260 omic techniques has raised expectations that
central questions of mixture toxicology such as for mech
261 revented systematic reviewers from answering
central questions of the review may include insufficient
262 We have investigated the
central questions of the roles of cytoskeletal elements
263 ar activities has provided new insights into
central questions of virology and host cell biology.
264 To explore one of the
central questions on the lipid-lipid interactions in the
265 A
central question regarding alpha4beta1 function is how i
266 A
central question regarding helicase activity is whether
267 Thus, our data answer a
central question regarding regulation of Ku in DSB repai
268 One of the
central questions regarding helicase activity is whether
269 This Opinion article addresses two
central questions regarding the nature of motivation: wh
270 hemistry, cell biology, and physiology, many
central questions regarding the polymers themselves are
271 age-related macular degeneration (AMD), but
central questions regarding their contributions to AMD p
272 A
central question related to virtually all social decisio
273 A
central question relates to mechanochemical coupling in
274 aeological and linguistic research; however,
central questions remain unresolved.
275 Nevertheless, a
central question remains as to whether such inhibitors a
276 out the clinical immunology of AIDS, and the
central question remains of how CD4 cell loss relates to
277 mechanisms could account for synergy, but a
central question remains of whether synergism requires t
278 However, despite this wealth of attention, a
central question remains unanswered: "What regulates flu
279 However, a
central question remains unresolved: what type of magnet
280 Among those, the position of Ruminantia is a
central question,
still to be solved.
281 Our results can be used to explore
central questions such as whether microorganisms form a
282 Therefore, a
central question that any candidate mechanism has to ans
283 A
central question that emerges is whether immune and infl
284 ithin the context of anthropogenic change, a
central question that remains is how important are direc
285 gression, and early chemoprevention, but the
central question that remains is whether radical treatme
286 One of the
central questions that has occupied those disciplines co
287 This review points to some
central questions that need to be addressed to better un
288 The
central question this Perspectives in Diabetes raises is
289 A
central question to biology is how pathogenic bacteria i
290 s to combat the opioid epidemic represents a
central question to G protein coupled receptor structura
291 controlling nuclear hormone receptors are a
central question to mammalian developmental and disease
292 models facilitates the genetic analysis of a
central question under investigation.
293 This is the
central question we address.
294 To address this
central question,
we performed paired recordings in prim
295 Guided by six
central questions,
we propose an integrative bottom-up a
296 To shed light on these
central questions,
we used all-atom, long-time-scale mol
297 ng and habit learning interact and answers a
central question:
What are the relative contributions of
298 This diversity highlights a longstanding
central question:
what controls regioselective homolytic
299 Evolutionary origin of muscle is a
central question when discussing mesoderm evolution.
300 ng health care teams requires attention to 2
central questions:
who is on the team and how do team me