ライフサイエンスコーパス: central role

1 ral circuit in which the hippocampus plays a central role.

2 t and intestinal lumen, with CCL20 playing a central role.

3 ntially, open-access publishers could play a central role.

4 rapamycin (mTOR) signaling networks plays a central role.

5 lity, in which the RAD51 recombinase plays a central role.

6 the TM domain (TMD) of the receptor plays a central role.

7 eus accumbens (NAc) has been shown to play a central role.

8 tase activity of thioredoxins (TRXs) plays a central role.

9 g these, multi-parent populations now play a central role.

10 ated protein (YAP) signaling network plays a central role as an integrator of signals that control ce

11 al and lexical characteristics points to its central role as the orthographic lexicon-the long-term m

12 ct is integral to decision-making, serving a central role both in the subjective experience of choice

13 undergoes DSI only at IT cells, confirming a central role for CCK+ interneurons.

14 These findings reinforce the central role for Cic in SCA1 cerebellar pathophysiology

15 A central role for confidence in shaping the fidelity of e

16 While nonlinearities play a central role for cutting-edge functionality, they requir

17 Taken together, our data point to a central role for EBV in mediating the tumour suppressive

18 In this review, we propose a central role for epithelial cell dysfunction that accoun

19 We show a central role for flotillin in the endocytotic recycling

20 Our data establish a central role for genes that were previously identified a

21 Together these results demonstrate a central role for idiosyncratic cognitive processing in h

22 Our data indicate a central role for IFT54 in binding the IFT motors during

23 This work reveals a central role for PvfB in the biosynthesis of (dihydro)py

24 Our results demonstrate a central role for skin expressed IL-23 in the initiation

25 This familial genetic study indicates a central role for Sp1 in causing autosomal dominant trans

26 These studies suggest a central role for SR-A complexes in epidermal lipid rafts

27 es of nephrotic syndrome (NS) has revealed a central role for the actin regulators RhoA/Rac1/Cdc42 an

28 Our structure also indicates a central role for the ArpC3 subunit in stabilizing the ac

29 Leading neuroscientific theories posit a central role for the functional integration of cortical

30 We propose a central role for the host factor ILF3 in enhancing expre

31 Here, we identify a central role for the human DEDD deadenylase TOE1 in dist

32 man physiology and epigenomic data support a central role for the pancreatic islet in the pathogenesi

33 ector-independent memory trace and uncover a central role for the PPC in its representation.

34 Our findings elucidate a central role for tonic TCR signaling in early T(FH) cell

35 These findings highlight the central role genetic variation at the FADS locus plays i

36 CD81 plays a central role in a variety of physiological and pathologi

37 nguage ("Boys like blue") often occupies the central role in accounts of the formation of essentialis

38 ase-activated Ca(2+) (CRAC) channels plays a central role in activation of a range of cellular respon

39 tmospheric CO(2) concentration have played a central role in algal and plant adaptation and evolution

40 ith ischemia/reperfusion injury (IRI) play a central role in alloimmunity and transplant outcomes.

41 Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drive

42 ing CD8-positive (CD8+) T lymphocytes play a central role in antitumor immune responses.

43 Paradoxically, mitochondria also have a central role in apoptotic cell death.

44 Reactive oxygen species (ROS) play a central role in aqueous-phase processing and health effe

45 en single-celled marine organisms can have a central role in biogeochemical processes and are of grea

46 mily members go some way to explaining their central role in biotic stress resilience.

47 Adipose tissue (AT) plays a central role in both metabolic health and pathophysiolog

48 d to insulin/IGF-1, the adipose tissue has a central role in both the metabolic and lifespan effects

49 ages are heterogeneous immune cells having a central role in both tissue homeostasis and inflammation

50 dependent protein kinase II (CaMKII) plays a central role in Ca(2+) signaling throughout the body.

51 sticity is increasingly recognized to play a central role in cancer biology.

52 ce indicates that the nervous system plays a central role in cancer pathogenesis.

53 The E2F family, classically known for a central role in cell cycle, has a number of emerging rol

54 on1-Ccz1-C18orf8 (MCC) GEF therefore plays a central role in cellular cholesterol homeostasis coordin

55 Our results indicate that Rme1 plays a central role in chlamydospore development in Candida spe

56 Serotonin plays a central role in cognition and is the target of most phar

57 enlarged raptorial "great appendages" with a central role in competing hypotheses on the early evolut

58 n the accessory olfactory bulb (AOB) plays a central role in conspecific chemosensory communication.

59 ution of fitness effects of mutation plays a central role in constraining protein evolution.

60 iana), the transcription factor ILR3 plays a central role in controlling Fe homeostasis.

61 Promoters play a central role in controlling gene regulation; however, a

62 g revealed that multiphase chemistry plays a central role in controlling indoor chlorine and reactive

63 Auxin plays a central role in controlling plant cell growth and morpho

64 ATM is a DDR kinase that has a central role in coordinating DNA repair and cell-cycle r

65 Pleiotropy plays a central role in debates about how complex traits evolve

66 -based innate immune effector network with a central role in determining the outcome of M. tuberculos

67 Despite this central role in development and evolution, the LPM remai

68 irus 2 (SARS-CoV-2) diagnostic assays play a central role in diagnosis and have fixed technical perfo

69 leles, suggesting that tRNA charging plays a central role in disease pathogenesis.

70 mpanied by enhanced adrenergic drive plays a central role in disease-related activation of the channe

71 lic dysfunction, including fibrosis, plays a central role in DM pathogenesis.

72 Immune cells play a central role in early pregnancy establishment in cattle.

73 Connectivity has long played a central role in ecological and evolutionary theory and i

74 fundamental biological process that plays a central role in embryonic development, tissue regenerati

75 subcellular organelles best known for their central role in energetics, producing adenosine triphosp

76 Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tiss

77 Polymer brush patterns have a central role in established and emerging research discip

78 ependent kinase (CDK) inhibitor that plays a central role in establishing endoreplication, and is the

79 nown that the microtubule cytoskeleton has a central role in establishing neuronal polarity, how its

80 n Cervical spinal cord MRI involvement has a central role in explaining disability in multiple sclero

81 agouti-related peptide (AgRP) neurons play a central role in feeding and are under complex regulation

82 fraction of DOC and that DOC likely plays a central role in foam formation.

83 s is itself a beta-barrel protein that has a central role in folding other beta-barrels.

84 Although the NDC80 complex plays a central role in forming and regulating attachments to mi

85 Large RNA-binding complexes play a central role in gene expression and orchestrate producti

86 Glycogen plays a central role in glucose homeostasis and is abundant in s

87 Tandem mass spectrometry has played a central role in glycan analysis, and recent work has sho

88 cardiac interventions in which TEE played a central role in guiding the procedure (mitral and tricus

89 B lymphocytes play a central role in host immunity.

90 Motivation plays a central role in human behavior and cognition but is not

91 Despite its central role in human health and disease, the constituen

92 Peroxisomes play a central role in human health and have biochemical proper

93 Regular exercise has a central role in human health by reducing the risk of typ

94 The human gut microbiome plays a central role in human health, and has been implicated in

95 Cattle pastoralism plays a central role in human livelihood in Africa.

96 MALT1 plays a central role in immune cell activation by transducing NF

97 BTK), a cytoplasmic tyrosine kinase, plays a central role in immunity and is considered an attractive

98 or of the innate immune response and plays a central role in inflammatory diseases by mediating the e

99 active sites of Rubisco and thereby plays a central role in initiating and sustaining Rubisco activa

100 itously found across all kingdoms, playing a central role in intracellular metabolism, especially in

101 ic genes, such as TBR1, are likely to play a central role in its neuronal organization, as well as on

102 ories, such reversed processing also plays a central role in later stages of perception.

103 irect contact with lipids and likely plays a central role in lipid sensing.

104 Given the pathway's central role in maintaining cellular and physiological h

105 sicles to their desired destinations plays a central role in maintaining proper cell functionality.

106 or hematopoietic differentiation and plays a central role in malignant disease.

107 Glycoproteins play a central role in many biological processes including dise

108 orsomedial striatum (DMS) of rodents plays a central role in mechanisms underlying excessive alcohol

109 Calcium (Ca(2+)) plays a central role in mediating both contractile function and

110 However, besides its central role in mediating hippocampal-prefrontal communi

111 diate depletion of adenylates, which plays a central role in mediating mTOR inactivation and inhibiti

112 E TRANSCRIPTION FACTOR 1 (RITF1), that has a central role in mediating RGF1 signalling.

113 mportant cellular degradation pathway with a central role in metabolism as well as basic quality cont

114 Their central role in metabolism, complex life cycle, and uniq

115 The liver plays a central role in metabolism, protein synthesis and detoxi

116 Although altered energetics play a central role in MH, MH-susceptible humans and mouse mode

117 /Parkin pathway has been described to play a central role in mitochondrial homeostasis by signalling

118 )(1), two key fossil assemblages that have a central role in models of Pleistocene hominin morphology

119 We infer that AGO4-dependent smRNAs play a central role in modulating JA biogenesis and signaling d

120 of G-protein signaling (RGS) proteins play a central role in modulating signaling via G-protein coupl

121 nt necroptosis and that this pathway plays a central role in mortality following superinfection.

122 Glycinergic synapses play a central role in motor control and pain processing in the

123 PKCtau/lambda plays a central role in NT-mediated alpha-defensin gene expressi

124 RNRs' central role in nucleic acid metabolism has resulted in

125 hat the dual-purpose salvage pathway plays a central role in numerous environments, notably the human

126 HA plays a central role in numerous functions of the endothelial su

127 uced regulatory T cells (pTreg cells) play a central role in oral tolerance to dietary antigens and c

128 of calcium ions (Ca(2+)), is critical to its central role in orchestrating neurotransmitter release.

129 ral lobe of the brain, the hippocampus has a central role in our ability to remember, imagine and dre

130 Genetic variation within CREs plays a central role in phenotypic variation in complex traits i

131 face receptors and their interactions play a central role in physiological and pathological signaling

132 both low oxygen and cAMP are known to play a central role in placental function, their regulation of

133 all-molecule signaling is presumed to play a central role in plant rhizosphere interactions.

134 Living polymerizations currently play a central role in polymer chemistry.

135 Simulation plays a central role in population genomics studies.

136 Microglial activation plays a central role in poststroke inflammation and causes secon

137 heterooctameric protein complex that plays a central role in primary cilia homeostasis.

138 te with syllabic information and that play a central role in production and perception processes.

139 hown that the host factor perforin-2 plays a central role in protecting mice and cells against infect

140 found that electrostatic interactions play a central role in protein diffusion; the disordered tubuli

141 t shock protein 70 (HSP70) chaperones play a central role in protein quality control and are crucial

142 anscribed genes in the genome owing to their central role in protein synthesis.

143 A neuronal population with a central role in puerperal changes is the tuberoinfundibu

144 luding CC chemokine ligand 2 (CCL2), plays a central role in recruitment of monocytes in several infl

145 cus on ROS at physiological levels and their central role in redox signalling via different post-tran

146 Mitochondria have a central role in regulating a range of cellular activitie

147 1-UEV and polymerization of ALIX-PRD and its central role in regulating ALIX function.

148 POP plays a central role in regulating cell proliferation in the Aqu

149 suggest that this kinase has an ancient and central role in regulating ciliogenesis throughout Eukar

150 The unfolded protein response (UPR) plays a central role in regulating endoplasmic reticulum (ER) an

151 cus on how circadian processes, which have a central role in regulating sleep/wake cycles, impact act

152 ults demonstrate that Rho GTPases may have a central role in regulating the broad characteristics of

153 icrobial carbon use efficiency (CUE) plays a central role in regulating the flow of carbon through so

154 Translational control plays a central role in regulation of gene expression and can le

155 real time, thus allowing the study of their central role in remodeling the bone-matrix in healthy an

156 Despite their central role in RNA function, the RNA-binding specificit

157 particular, the default mode network plays a central role in semantic processing for abstraction of c

158 Glycoconjugates play a central role in several cellular processes, and alterati

159 G-protein-coupled receptors (GPCRs) plays a central role in signal transduction and is uniquely posi

160 d the adhesion molecule Jam-C, which plays a central role in stemness maintenance of hematopoietic an

161 Hepatocytes play a central role in storage and utilization of fat by the li

162 Thrombosis and platelet activation play a central role in stroke pathogenesis, and antiplatelet an

163 a unique giant GABAergic neuron that plays a central role in structuring olfactory codes in the locus

164 These results indicate that the RdRp plays a central role in SVA replicative recombination.

165 Metabolic reprogramming plays a central role in T cell activation and differentiation, a

166 odal perception action coupling, which has a central role in temporal expectations.

167 l proteolysis regulated by proteases plays a central role in the 'life and death' cellular processes,

168 Norepinephrine (NE) plays a central role in the acquisition of aversive learning via

169 ough their pollination activities and play a central role in the biodiversity of entire ecosystems.

170 e apicoplast Clp system and demonstrates its central role in the biogenesis of the plastid in malaria

171 ntary tracts of herbivores where they play a central role in the breakdown of plant material.

172 The central nervous system (CNS) plays a central role in the control of sensory and motor functio

173 PlsX plays a central role in the coordination of fatty acid and phosp

174 Lytic reactivation plays a central role in the development of EBV-driven cancers an

175 Since opioid receptor activity plays a central role in the development of tolerance and addicti

176 Dendritic cells (DCs) play a central role in the early immune response against B. bur

177 embryonic germ layers, the mesoderm plays a central role in the establishment of the vertebrate body

178 Genomic conflicts may play a central role in the evolution of reproductive barriers.

179 ginal chemical approach that it could play a central role in the field of nanomedicine, with novel pe

180 lent ytterbium ions (Yb(3+) ), have played a central role in the first demonstrations and subsequent

181 Results show the capsid protein plays a central role in the flavivirus assembly process.

182 rowth-associated protein 43 (GAP-43) plays a central role in the formation of presynaptic terminals,

183 Hence, Pol II plays a direct and central role in the gene-specific regulation of tRNA exp

184 Whole-genome duplication has played a central role in the genome evolution of many organisms,

185 AD and its co-repressor VGL4, both playing a central role in the Hippo signalling pathway.

186 stability is a hallmark of cancer, and has a central role in the initiation and development of breast

187 with the medial prefrontal cortex playing a central role in the integration of perspectives related

188 abolic building blocks to ascarosides play a central role in the life history of C. elegans and other

189 growth factor (VEGF) pharmacotherapy plays a central role in the management of neovascular age-relate

190 ating-type switching endonuclease HO plays a central role in the natural life cycle of Saccharomyces

191 This circuit plays a central role in the nicotine withdrawal response.

192 er-regulatory renin-angiotensin system has a central role in the pathogenesis and development of vari

193 s of the beta-amyloid peptide, Abeta, play a central role in the pathogenesis and progression of Alzh

194 Inflammation plays a central role in the pathogenesis of acute lung injury (A

195 Oxidative stress in adipocyte plays a central role in the pathogenesis of obesity as well as i

196 it is widely believed that alpha-syn plays a central role in the pathogenesis of PD, the processes th

197 dependent mCG, consistent with mCH playing a central role in the pathogenesis of Rett Syndrome.

198 uggest that epigenetic regulation may play a central role in the pathogenesis of sepsis.

199 The microtubule-associated protein tau has a central role in the pathogenesis of several forms of dem

200 OPTN and SQSTM1) suggests that it may play a central role in the pathogenesis of these disorders.

201 The insular cortex plays a central role in the perception and regulation of bodily

202 Tapasin plays a central role in the PLC, stabilizing the MHC-I binding g

203 The dentate gyrus (DG) plays a central role in the process of memory formation, prompti

204 pulation in atherosclerotic plaques and play central role in the progression of this lipid-driven chr

205 ine-induced immunity is considered to play a central role in the reemergence of mumps among vaccinate

206 Macrophages play a central role in the regulation of inflammation, resoluti

207 Therefore, MAP3K8 has a central role in the regulation of inflammatory responses

208 he plant hormone abscisic acid (ABA) plays a central role in the regulation of stomatal movements und

209 alpha-cells of the pancreatic islets play a central role in the regulation of systemic metabolism.

210 to the fungus Pneumocystis jirovecii plays a central role in the respiratory failure associated with

211 Species interactions play a central role in the response of ecosystems to climate ch

212 sts that critical charge fluctuations play a central role in the strange metal behavior, elucidating

213 scopic evaluation of resected tissue plays a central role in the surgical management of cancer.

214 Modulation of dopamine may play a central role in the underlying circuit.

215 study of van der Waals interactions plays a central role in the understanding of bonding across a ra

216 Cardiac fibroblasts (CFs) have a central role in the ventricular remodeling process assoc

217 eus, interactions between chromosomes play a central role in their organization.

218 foremost of the ancient Maya cities, plays a central role in this discussion because of its sharp pop

219 tory element-binding proteins (SREBPs) has a central role in this process.

220 Phosphorylation plays a central role in timing the clock, but how this contribut

221 (2+) -sensing protein calmodulin (CaM) has a central role in tuning Na(V) function to [Ca(2+) ](i) ,

222 ins directly activated by cAMP (EPAC) play a central role in various biological functions, and activa

223 arget of high biological interest due to its central role in various cancers.

224 Coat proteins have a central role in vesicular transport by binding to cargoe

225 ological processes, but whether size plays a central role in viral ecology is unknown.

226 HIV-1 full-length RNA (HIV-1 RNA) plays a central role in viral replication, serving as a template

227 In other species, the SC plays a central role in voluntary as well as innate visual funct

228 Nucleosides play central roles in all facets of life, from metabolism to

229 teria, many of which have been shown to play central roles in bacterial infections that result in maj

230 oth within and between individuals, can play central roles in both motivating and constraining socioc

231 gulated kinase (ERK) signaling pathways play central roles in cancer cell metabolic adaptation given

232 throughout most of folliculogenesis and play central roles in controlling ovarian physiology.

233 rganization, and differentiation, which have central roles in embryonic development [1-6].

234 s, including transporters and channels, play central roles in environmental sensing in these parasite

235 smORFs) and their encoded microproteins play central roles in microbes.

236 Despite their central roles in RNA metabolism, insight into the molecu

237 anslational modifications (PTMs), which play central roles in the activation of transcriptional progr

238 overview of a multitude of factors that play central roles in the fluorescence of CuNCs.

239 for therapeutic intervention owing to their central roles in various biological processes and pathol

240 ired pulmonary vascular reserve (VR) plays a central role linking these abnormalities, and that patie

241 The human gut microbiota plays a central role not only in regulating the metabolism of nu

242 ling pathways in these mice and discovered a central role of a nonreceptor tyrosine kinase, spleen ty

243 Scholars have long argued for the central role of agency-the size of one's choice set-in t

244 However, the central role of alpha-klotho in metabolism remains large

245 we report regulatory mechanisms unveiling a central role of Alu elements (AEs) and RNA polymerase II

246 Subsequently, we establish the central role of AQP4 in the glymphatic clearance of tau

247 ning of vessel transformation limits and the central role of Atlantic cod, which is the main target s

248 In particular, the central role of B cells in the disease has been demonstr

249 between CAF and immune cells and reveals the central role of CAF in establishing a hospitable inflamm

250 Our results indicate a central role of CD44 signaling in HMWH-induced antihyper

251 Further validation reveals the central role of chaperones, stress response proteins and

252 The results highlight the central role of crop rotation for mitigating impacts of

253 Consistent with the central role of CWC15 in RNA splicing, cwc15 mutants are

254 Our findings demonstrate the central role of electronic-nuclear mixing in efficient l

255 Our data highlight the central role of FN-RGD and the functionality of FN-RGE f

256 In this study, we uncovered the central role of genetic dominance shaping genetic cargo

257 reast cancer patients and thus emphasize the central role of genomic instability vis-a-vis tumor aggr

258 oscopy and genetics were used to confirm the central role of GLR3.3 in the amino acid-elicited cytoso

259 n rapid advances in the understanding of the central role of glucocorticoids in preparing the fetus f

260 Despite the central role of HGT, the evolutionary forces that drive

261 also heterogeneous but are consistent with a central role of human mobility.

262 y, which demonstrates the location-dependent central role of IL-15 in the pathogenesis of coeliac dis

263 hedding light on pathogenesis, including the central role of innate immune effector cells and subsequ

264 These results establish the central role of LARP1 in TOP mRNA regulation on a transc

265 There is also growing recognition of the central role of leaf starch turnover in making carbon av

266 Given the central role of MDM2 in suppressing p53 protein levels a

267 Emerging evidence points to a central role of mitochondria in psychiatric disorders.

268 These findings reinforce the central role of My-T-BCR-dependent NF-kappaB signaling i

269 economics than AMF-hosts, demonstrating the central role of mycorrhizal symbiosis in plant resource

270 Although the central role of NAD in plant metabolism and its regulato

271 Growing evidence supports a central role of NADPH oxidases (NOXs) in the regulation

272 Ample evidence points to central role of NF-kappaB in such pathologic responses,

273 With the central role of nucleic acids there is a need for develo

274 Given the central role of ovBNST in mediating maladaptive behavior

275 Our results posit a central role of parietal regions in shaping multisensory

276 ovascular disease processes, focusing on the central role of particular NADPH oxidase (NOX) isoforms

277 Despite the central role of past experiences, it remains unclear whe

278 Despite the central role of reactive organic carbon (ROC) in the for

279 r data in a murine asthma model illustrate a central role of regulatory B cells in the control of lun

280 Together, these data reveal the central role of secreted polysaccharides in the intricat

281 er recent results supporting the idea of the central role of sharing agency in socioaffective and mot

282 lysis, our data demonstrate an essential and central role of the CCR4-NOT complex in human brain deve

283 Several studies reported a central role of the endothelin type A receptor (ETAR) in

284 These results demonstrate the central role of the iron-sulfur cluster domain of HydF i

285 The central role of the islet is also demonstrated by numero

286 The central role of the renin-angiotensin system is discusse

287 Our data highlight the central role of the RNA helicase Mtl1 in regulation of t

288 actionable PAH gene and further support the central role of the vascular endothelium in the pathobio

289 of RPE value (during learning), suggesting a central role of these areas in episodic memory formation

290 ression is silenced, again demonstrating the central role of this receptor in relaying the effects of

291 iously for glucose transport, confirming the central role of this residue for the transport mechanism

292 other pathogens, such as influenza), and the central role played by SSEs on transmission dynamics can

293 rocess, Judson brings out of the shadows the central roles played by women in many of the era's disco

294 Altogether, these results confirm the central role small RNAs play in shaping regulatory chang

295 The central role that erythrocyte invasion plays in Plasmodi

296 wild organisms, particularly because of the central role that light regimes play in determining the

297 ics in diagnosing allergic disorders and the central role that omics play in creating molecular signa

298 me VBH models do not acknowledge radiology's central role; this may have future negative consequences

299 utational tools like antiSMASH have played a central role through the analysis of Biosynthetic Gene C

300 ven activated T reg (aT reg) cells playing a central role; yet how TCR signaling propagates to contro