ライフサイエンスコーパス: centrally

1 Adelta-fibers (peripherally) and HT neurons (centrally).

2 All responses were reviewed centrally.

3 its derivatives NFP and NYP actually can act centrally.

4 n to activate the sympathetic nervous system centrally.

5 axon collaterals that influence motor output centrally.

6 ser IVCM was performed in the corneal grafts centrally.

7 synaptic contacts for conveying information centrally.

8 Available HRCT scans were reviewed centrally.

9 zation induced by tissue damage was mediated centrally.

10 outer rim of viable cells but necrotic cells centrally.

11 cases of new-onset diabetes were adjudicated centrally.

12 Randomization was done centrally.

13 that controls gut functions peripherally and centrally.

14 n essential propulsive force to return lymph centrally.

15 We randomly allocated participants centrally (1:1) to either surveillance or four 21-day cy

16 Randomisation was done centrally (1:1:1) by a computerised system using an inte

17 ths before screening) were randomly assigned centrally (1:1:1:1), via interactive response technology

18 Patients were randomly assigned centrally (1:1:1:1:1:1), via an interactive response tec

19 r sporadic ALS were randomly assigned (1:1), centrally according to a computer-generated allocation s

20 amples were analyzed by histology and scored centrally according to the NASH Clinical Research Networ

21 Clinical development of the centrally acting CB1 inverse agonist otenabant (1) was h

22 forming a glucogenic function, asprosin is a centrally acting orexigenic hormone that is a potential

23 ely metabolized in rats, but MDC is the only centrally active metabolite that could contribute to ove

24 MIs were centrally adjudicated and categorized by type using the

25 MIs were centrally adjudicated and categorized by type using the

26 The final diagnosis was centrally adjudicated by 2 independent cardiologists usi

27 Clinical events were centrally adjudicated by a blinded committee.

28 Adverse events and centrally adjudicated cardiovascular events were similar

29 -2017) with long-term follow-up and blinded, centrally adjudicated cause of death were used to calcul

30 participants from 9 trials, there were 9259 centrally adjudicated deaths: 5012 (54.1%) attributable

31 Two cardiologists centrally adjudicated the final diagnosis using all clin

32 , and deaths were prospectively captured and centrally adjudicated.

33 Outcome events were centrally adjudicated.

34 Centrally administered glucagon-like peptide 1 (GLP-1) s

35 The effects of systemic or centrally administered orexin receptor (OXR) antagonists

36 y assigned (1:1) using a computer-generated, centrally administered procedure, stratified by trial ce

37 ion were randomized across 3 arms (1:1:1 via centrally administered system with variable-length rando

38 d that rats fed a high-fat diet or that were centrally administered thapsigargin displayed hypothalam

39 ), a circuit involved in memory encoding and centrally affected in Alzheimer's disease and temporal l

40 However, centrally aligned nuclei observed in muscle fibers sugge

41 Participants were centrally allocated by the study statistician to vaccine

42 agreement between Pittsburgh compound B and centrally analysed cerebrospinal fluid, a minority of su

43 All MRI scans were centrally analyzed; stiffness, proton density fat fracti

44 e found that this effect is in part mediated centrally and can be alleviated by altering motor cortex

45 e allocation sequence was computer-generated centrally and concealed to all personnel.

46 Mutant Nrp2 islets aggregated centrally and failed to disperse radially.

47 ted with reduced current generation capacity centrally and increased electrical load caudally.

48 e observed a macular pattern that was sparse centrally and peaked peripherally in healthy human eyes.

49 atory cytokine interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhag

50 into the pathological alterations occurring centrally and peripherally in PD.

51 ulators that orchestrate metaflammation both centrally and peripherally remains incompletely understo

52 tissues to regulate systemic metabolism both centrally and peripherally through secretion of adipocyt

53 nsitization and improved leptin action, both centrally and peripherally.

54 mpartments, with active euchromatin enriched centrally and silent heterochromatin at the nuclear peri

55 Patients were randomised centrally and stratified by hospital according to a pre-

56 Randomisation was done centrally and stratified by previous trastuzumab treatme

57 ies, act as immunomodulator peripherally and centrally, and it can reduce amyloid pathology in the br

58 tients who achieved an objective response by centrally assessed breast MRI and a locally assessed pat

59 in participants who received >=1 dose), were centrally assessed by investigators who were unaware of

60 cedures, and non-fatal and fatal stroke)-was centrally assessed by the GCS follow-up team, who were m

61 m the first injection to first assessment of centrally assessed estradiol level <= 2.72 pg/mL [<= 10

62 The primary end point was centrally assessed objective response rate (ORR); second

63 89 (24%, 95% CI 20-29) of 370 patients had a centrally assessed objective response, and as of Sept 1,

64 combined positive score of 10% or more had a centrally assessed objective response.

65 The primary end point was centrally assessed PFS.

66 2 (PET2) and 4 (PET4) induction cycles, and centrally assessed using international harmonization pro

67 tion of patients with an objective response (centrally assessed), defined as a complete or partial re

68 netic analysis completed within 7 d and were centrally assigned to a Beat AML sub-study; 224 (56.7%)

69 Intrusive memories and reactivity are centrally associated with other symptoms in the acute ph

70 Targeting the receptor with a new centrally available antagonist, JNJ-47965567, suppressed

71 ileptic mice with systemic injections of the centrally available, potent, and specific P2X7 receptor

72 tructures stabilized by Hoogsten pairing and centrally bound monovalent cations.

73 eral stimuli when the task requires focusing centrally but reduced filtering of central stimuli when

74 eptors (MORs) are expressed peripherally and centrally, but the loci of MORs responsible for clinical

75 ase 2, patients were randomly assigned (1:1) centrally by a computerised algorithm to intravenous cab

76 Patients were randomly assigned (1:1) centrally by an interactive voice and web response syste

77 Participants were randomly assigned (1:1) centrally by an interactive voice response system, to re

78 sured using standard audiometry and reviewed centrally by audiologists masked to allocation using Ame

79 Randomisation was done centrally by computer-generated permuted block method (v

80 entical appearance, via a sequence generated centrally by the data coordinating centre at Research Tr

81 to end of treatment (48 weeks), as assessed centrally by two independent pathologists.

82 rolled patients were randomly assigned (1:1) centrally by use of permuted blocks to receive induction

83 Exhaled metabolites were analyzed centrally by using an assembly of eNoses.

84 ide-chain composition, and the nature of the centrally chelated metal ion.

85 cluded all randomly assigned patients with a centrally confirmed BRCA mutation, and safety analyses i

86 We enrolled 326 centrally confirmed cases of AIS and 115 stroke-free con

87 70 years of age with newly diagnosed AML and centrally confirmed FLT3-ITD were eligible: 284 patients

88 nosed within 2 years prior to enrolment, and centrally confirmed glycated haemoglobin A1c (HbA(1c)) o

89 l were men and women (aged >/=18 years) with centrally confirmed HER2-positive advanced breast cancer

90 articipants were aged 18 years or older with centrally confirmed HER2-positive stage II-III operable

91 in all dosed patients and all patients with centrally confirmed MET amplification.

92 al (PFS), was evaluated in 183 patients with centrally confirmed non-GCB DLBCL who received one or mo

93 nto two parallel substudies according to the centrally confirmed pretreatment T790M mutation status o

94 ity criteria included age at least 18 years, centrally confirmed triple-negative breast cancer; at le

95 tients who provided consent, 341 (85.9%) had centrally confirmed, localized GISTs with mutation analy

96 ology Group performance status of 0 or 1 and centrally confirmed, measurable, HER2-positive advanced

97 Patients with melanoma or a centrally confirmed, PD-L1-positive, relapsed or refract

98 findings reveal that microneme secretion is centrally controlled by protein kinase G and that this p

99 was done with a web-based program, which was centrally controlled to ensure allocation concealment.

100 onserved region of the vertebrate brain that centrally controls responses to environmental stressors.

101 These results support the assumption that centrally coordinated intervention is an essential publi

102 Reactome pathways are centrally curated with periodic input from selected doma

103 unction is disrupted along nerves containing centrally derived myelin, demonstrating that, although p

104 tions to peripheral myelinating glial cells, centrally derived oligodendrocyte progenitor cells (OPCs

105 other prespecified genes, prospectively and centrally determined from tumor tissue.

106 Four hundred twenty-five centrally determined patient cases with TNBC from S9313

107 therapy, involved axillary lymph nodes, and centrally determined phenotype (basal v nonbasal, accord

108 timates for the outcomes of interest using a centrally developed statistical code with harmonized def

109 e desmoid tumours, normal organ function and centrally documented progressive disease according to Re

110 conclude that the pharmacodynamic effect is centrally driven.

111 ents, acute stroke-related headache might be centrally driven.

112 g a sponsor-generated randomisation sequence centrally executed by an interactive voice response or i

113 Randomisation was centrally executed using an interactive voice or web res

114 The centrally expressed melanocortin-3 and -4 receptors (MC3

115 The centrally expressed melanocortin-3 and melanocortin-4 re

116 evant opioid analgesia is mediated mostly by centrally expressed MORs.

117 s Patients with metastatic UBC were screened centrally for HER1/HER2 overexpression.

118 collected at annual study visits and graded centrally for late age-related macular degeneration (AMD

119 collected at annual study visits and graded centrally for late AMD.

120 collected at annual study visits and graded centrally for late AMD.

121 zumab 15 mg/kg every 21 days and were tested centrally for the pretreatment T790M resistance mutation

122 A randomisation schedule was centrally generated with fixed sized strata for Research

123 nd stereoscopic fundus photographs that were centrally graded for development of late AMD (central ge

124 igment epithelium: Group 1 (preserved NIR-AF centrally), Group 2 (only disrupted NIR-AF), or Group 3

125 Randomisation codes were obtained from a centrally held list via an interactive web response syst

126 for shuttling a single Ag or Cu atom into a centrally hollow, rod-shaped Au24 nanoparticle, forming

127 Centrally, IB4(+) , but not CTB(+) , projection areas we

128 Randomisation was centrally implemented using an interactive voice respons

129 Disruptions in fear-extinction learning are centrally implicated in a range of stress-related disord

130 With the medial frontal cortex (MFC) centrally implicated in several major neuropsychiatric d

131 one amyloid-beta (Abeta) peptides, which are centrally implicated in the pathogenesis of Alzheimer's

132 ed to be vital for kidney homeostasis and is centrally implicated in the pathogenesis of cisplatin-in

133 onic charge transfer with an electrode, is a centrally important challenge in the field of bioelectro

134 epithelium, where it gains access to fluids centrally important for horizontal transmission.

135 ecific recognition by a transcription factor centrally important for the pathogenesis of ICF syndrome

136 Boronic acids are centrally important functional motifs and synthetic prec

137 ecognition of 5caC by a transcription factor centrally important in brain development.

138 Measuring population-level transmission is centrally important in guiding schistosomiasis control p

139 etter understanding of the mechanism of this centrally important reaction.

140 marcate a constellation of elements that are centrally important to age-related cognitive impairments

141 ffects of both CpG and CpA modification on a centrally-important transcription factor, we show that C

142 KTxBx were read centrally in a blinded fashion according to Banff criter

143 th FGFR2 fusions or rearrangements, assessed centrally in all patients who received at least one dose

144 Randomisation was done centrally in blocks of 12, and stratified by trial centr

145 Randomisation was computer-generated centrally in blocks of four, stratified by site.

146 Randomisation was done centrally in each country.

147 ondrial functions, thus placing mitochondria centrally in maintaining homeostasis upon infection.

148 dent ILC2 activation in the lung is involved centrally in promoting tumor burden.

149 done via a web-based trial-management system centrally in real time, and treatment allocation was con

150 e is that the methylammonium ions do not sit centrally in the A-site cavity, but disordered around tw

151 ntral analysis computing features found more centrally in the auditory system, and an Object analysis

152 at ends temporally in the periphery and more centrally in the nasal side.

153 They are positioned centrally in the neurovascular unit between endothelial

154 ore than 150 clinical variables were curated centrally, including demographics, laboratory values, me

155 e emergent theme is that an association with centrally initiated neural activity, whether this is gen

156 pherally inserted central catheter than with centrally inserted central catheter (mean, 4.5 vs 3.3 L/

157 h peripherally inserted central catheter and centrally inserted central catheter (reference standard)

158 er injection of a cold saline bolus via both centrally inserted central catheter and either a single-

159 ncreasingly used in ICU as an alternative to centrally inserted central catheters for IV infusion.

160 Our analysis of SINCs suggests that NPR1 is centrally integrated into the cell death or survival dec

161 uneRegulation currently provides the largest centrally integrated resource on human transcriptome reg

162 ethanolamine) biosynthetic cascades as being centrally involved in MND, particularly hereditary spast

163 To test the hypothesis that the exocyst is centrally involved in podocyte development/function, we

164 iched, SR/ER membrane protein, REEP5 that is centrally involved in regulating SR/ER organization and

165 Hypoxia inducible factors (HIFs) are centrally involved in the modulation of cellular functio

166 s provide evidence that immune molecules are centrally involved in the orchestration of cardiac tissu

167 nts show that OLFM4-positive neutrophils are centrally involved in the pathologic pathway leading to

168 Reactive oxygen species are centrally involved in the pathophysiology of airway dise

169 t the local bulbar interneurons appear to be centrally involved in the process.

170 py) are covered, even if metal complexes are centrally involved in those.

171 Histone methyltransferase MLL4 is centrally involved in transcriptional regulation and is

172 (lower levels of circulating cytokines) and centrally (less activated microglia in the hypothalamus)

173 es beta1-integrin activity, the formation of centrally located active beta1-integrin- and tensin-rich

174 se influentially connected birds become more centrally located and in a poorer position to observe a

175 The single Pol alpha-primase is centrally located and may prime both sister replisomes.

176 In addition, the centrally located chiral (S)-BINOL motif of the [3]rotax

177 ment with the stellar disk(6,7), as are more centrally located clusters(8,9).

178 actin involves interaction of the essential centrally located domain.

179 Patients with centrally located early-stage non-small-cell lung cancer

180 a lower proliferation potential, compared to centrally located FCs.

181 ating embryo-wide reorganization driven by a centrally located force generator, and indicate a non-ca

182 ion on the functional importance of the most centrally located helices M5 and M6 in the transmembrane

183 nd characterize a +1-nt frameshift mutation, centrally located in rpoB, an essential gene encoding th

184 progressive participants presented with more centrally located lesions.

185 (LT) technique for patients having >=1 deep centrally located liver tumor, with or without middle he

186 ion tomography-staged T1 to 2 (<= 5 cm) N0M0 centrally located NSCLC were accrued into a dose-escalat

187 of stereotactic body radiotherapy (SBRT) for centrally located NSCLC.

188 rant to change, whereas several deletions of centrally located nucleotides in the 5' NTR led to signi

189 They assemble as tetramers with a centrally located pore domain surrounded by a voltage-se

190 Our evidence suggests that PrP's centrally located proline and lysine residues act as con

191 2.3, 95% confidence interval [CI] 1.4-3.8), centrally located tumor (HR 2.5, 95% CI 1.2-5.2), tumor

192 Nuclear (centrally located) cataracts were significantly more pre

193 g in challenging scenarios where tumors are: centrally located, > 5 cm in diameter, lacking tissue di

194 an international, phase 2, pivotal study of centrally manufactured tisagenlecleucel involving adult

195 d-brain barrier to reverse morphine-induced, centrally mediated analgesia when given intravenously.

196 ficacy of PAWS for detecting spinally versus centrally mediated behavioral responses, we chemogenetic

197 n interaction with glutamate, is involved in centrally mediated behavioral, transcriptional, and neur

198 zed to other stimulus locations indicating a centrally mediated component of sensitization.

199 icrobiota-immune-stress matrix may influence centrally mediated events and on possible therapeutic in

200 local inflammatory phenomenon rather than a centrally mediated phenomena.

201 al appraisal in humans is often considered a centrally mediated process by which sensory signals, voi

202 rom peripheral acyl-ghrelin binding, whereas centrally-mediated alteration of energy storage requires

203 We further show that SYK centrally mediates signaling upstream of caspase-1 and c

204 alytic peptide was incorporated either via a centrally modified nucleotide (Type 1) or through an aba

205 As presynaptic inhibition (PSI) is centrally modulated to allow execution of supraspinal mo

206 As presynaptic inhibition (PSI) is centrally modulated to allow execution of supraspinal mo

207 tokine surges both systemically (plasma) and centrally (NTS and RVLM) and reduced hypothalamic PGE(2)

208 would localise haloperidol's activity either centrally or peripherally, dependent on the location of

209 t-diameter 0.8 degrees ), that was presented centrally, or 7.5 degrees to the left or right of fixati

210 is-retinal detachments and those with large, centrally overhanging schisis cavities were excluded fro

211 (n = 4), whereas 1.8% demonstrated a large, centrally overhanging schisis cavity requiring surgery (

212 Minocycline, a centrally-penetrant tetracycline antibiotic, inhibits mi

213 Radiographic responses were assessed centrally per Response Evaluation Criteria in Solid Tumo

214 ing interphase and positive signaling by the centrally placed nucleus at mitotic entry [2-4]: the cel

215 n transfer from a highly conserved histidine centrally positioned in the transport path.

216 The scrunched NT loop is stabilized by the centrally positioned MTF1 C-tail.

217 ubthalamic nucleus (STN) neurons form a key, centrally positioned network within the basal ganglia.

218 -related temporal coding deficits arise more centrally, possibly due to a loss of auditory nerve fibe

219 1:1) by the general practice clinics using a centrally prepared computer-generated randomisation sequ

220 tial orienting and a nonspatial feature of a centrally presented stimulus in nonprimate species.

221 's classic endogenous cuing task, in which a centrally presented, spatially informative cue is follow

222 a visual detection paradigm to two types of centrally-presented stimuli.

223 rent timing in the periphery of neurons that centrally produce temperature-robust activity.

224 After a dorsal root crush injury, centrally-projecting sensory axons fail to regenerate ac

225 nario where one opinion, through nudging, is centrally pushed to all users.

226 sequence with a block size of four or six to centrally randomise patients to image-guided MISTIE trea

227 Patients were centrally randomised (1:1) to receive either oral masiti

228 Patients were centrally randomised (2:1) and stratified by risk catego

229 Participants were centrally randomized into intervention (22,600 ppm fluor

230 oned an interactive voice response system to centrally randomly assign patients (1:1) based on a fixe

231 Patients were then centrally randomly assigned (1:1) via a web-based system

232 up performance status of 0-2 were recruited, centrally randomly assigned (1:1) with permuted blocks (

233 Anesthesiologists score of 2 or lower, were centrally randomly assigned (1:1), using an interactive

234 1 and August 2014, 1,670 adult patients were centrally randomly assigned (1:1:1) to ipi3 (n = 523), H

235 therapy, and study group language, and were centrally randomly assigned 1:1 using randomly permuted

236 surgical samples, analyzed independently and centrally re-reviewed in a blinded manner, were used as

237 zed histologic outcomes were evaluated using centrally read biopsies.

238 nd points were response and mucosal healing (centrally read) at week 8.

239 We centrally reanalysed individual-level data from 13 427 w

240 GLP1 administered centrally reduces food intake and increases anxiety-like

241 in lipase (LPL) in astrocytes is required to centrally regulate energy homeostasis.

242 We show that caveolin-1 (Cav1) centrally regulates exosome biogenesis and exosomal prot

243 ed in zebrafish by the two AgRPs, with AgRP1 centrally regulating food consumption and AgRP2 acting a

244 on screening for relevant abnormalities were centrally reviewed and were informative in 542 cases (88

245 ysis was performed by using patient data and centrally reviewed baseline PET-CT scans for 185 patient

246 ts, was overall response at week 25, and was centrally reviewed by RECIST, version 1.1.

247 s of standard R-CHOP therapy and underwent a centrally reviewed interim PET/computed tomography scan

248 -to-treat population as assessed by blinded, centrally reviewed MRI or CT.

249 6 to August 2013, 588 prospectively treated, centrally reviewed patients with stage III FHWT were tre

250 od, Barrington et al present the analyses of centrally reviewed positron emission tomography-computed

251 ients were enrolled and imaging studies were centrally reviewed to assess for bilateral renal lesions

252 Images were centrally reviewed with the use of a 5-point scale for P

253 tomography scans and pathology reports were centrally reviewed, and information was collected regard

254 e, and at least 1 month after treatment were centrally reviewed.

255 Imaging was centrally reviewed.

256 Histologic features were centrally scored according to Banff guidelines, includin

257 Multi-institutional collaborations based on centrally-shared patient data face privacy and ownership

258 A centrally situated triangle served as a prop for quantit

259 vel rapidly increases in young mice that are centrally stimulated with insulin.

260 analytic solutions to the inverse design of centrally symmetric and even general surfaces, in an app

261 All samples were centrally tested for HPV DNA by polymerase chain reactio

262 rticularly occur in corneas that are flatter centrally than the periphery because of edematous change

263 dbrain vocal central pattern generator (CPG) centrally, that produce sex- and species-characteristic

264 Centrally, the 24-2C grid identified more clusters of de

265 reams of information must then be integrated centrally to achieve a unified percept of texture.

266 Long-chain fatty acids (FAs) act centrally to decrease food intake and hepatic glucose pr

267 The 78 imaging studies were analyzed centrally to derive the volume transfer constant (K(tran

268 stereoscopic fundus photographs were graded centrally to detect DPED, a well-defined yellow elevated

269 Patients were randomly assigned 1:1 centrally to either the docetaxel, prednisone, and custi

270 ide kisspeptin and its receptor, Kiss1r, act centrally to stimulate reproduction.

271 rrounding the snout whiskers and transmitted centrally to the brainstem (barrelettes), the thalamus (

272 ble circular or targetoid, often raised, and centrally ulcerated lesions covering up to 70% of the bo

273 Randomisation was done centrally using a computerised minimisation program, str

274 MD was read centrally using a quantitative method (Cumulus) and its

275 igible patients were randomly assigned (2:1) centrally using an interactive response technology syste

276 Randomisation occurred centrally using an interactive voice response system and

277 tation analysis for KIT and PDGFRA performed centrally using conventional sequencing.

278 inimal residual disease (MRD) was determined centrally using flow cytometry at two reference laborato

279 Summary-level results were meta-analyzed centrally using inverse-variance weighting.

280 status of 0-2 were randomly assigned (1:1:1) centrally using minimisation to group 1 (intravenous car

281 Patients were randomly assigned (1:1) centrally using permuted blocks (block size 8) to receiv

282 Randomisation was done centrally using the Theradex Interactive Web Response Sy

283 Randomisation was done centrally (using block randomisation with a block size o

284 or group B (chemotherapy plus bevacizumab), centrally, using permuted blocks sizes and stratified by

285 Randomisation was carried out centrally, using the eClinicalOS electronic data capture

286 Centrally, vagal neurons projecting to the pancreas term

287 rrently with chemotherapy), then implemented centrally via an interactive voice and web-response syst

288 ck size three) randomisation procedure, done centrally via an interactive voice or web response syste

289 Patients were randomly assigned (1:1:1) centrally via an interactive voice or web response syste

290 allocation at the investigator site was done centrally via internet with stratification for chemother

291 ccentricity-dependent variation (0.13 mum/yr centrally vs 0.06 mum/yr peripherally); however, average

292 on signaling via MyD88 when it is delivered centrally, whereas this response is mediated via the TRI

293 All patients were randomly assigned centrally with a permuted block randomisation schedule.

294 Randomisation was done centrally with an interactive voice or web-response syst

295 ation was stratified by country and was done centrally with an interactive voice-response or web-resp

296 andomisation, with permuted blocks, was done centrally with an interactive web response system.

297 Randomisation was done centrally with minimisation factors of surgical centre,

298 Tumor biopsy specimens were analyzed centrally with next-generation sequencing (NGS) in a mas

299 nancies at 1,117 accrual sites were analyzed centrally with NGS and selected immunohistochemistry in

300 component of these oscillations is generated centrally, with respiratory neurons entraining the activ