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1                               Galantamine, a centrally acting acetylcholinesterase inhibitor, has bee
2 monstrate that galantamine, a reversible and centrally acting AChE inhibitor approved for treatment o
3 tor, and it was less toxic than huperzine, a centrally acting AChE inhibitor.
4 plied to all anticonvulsant trials and other centrally acting agents and nonpsychotropic drugs.
5  is the prototype for the development of new centrally acting agents targeting specifically I1imidazo
6 iuretics, alpha-blockers, beta-blockers, and centrally acting agents), for a mean of 3.4 years.
7 omimetic actions can be reversed by a potent centrally acting alpha2 adrenergic receptor (AR) agonist
8  (via 48 h transdermal administration of the centrally acting alpha2-adrenergic receptor agonist, clo
9 The increased basal BP was attenuated by the centrally acting alpha2a agonist guanfacine, suggesting
10 m circuitry and that cannabinoids are indeed centrally acting analgesics with a new mechanism of acti
11 ve injury (neuropathic pain) is resistant to centrally acting analgesics, whereas inflammatory pain r
12 o lever-press for cocaine hydrochloride (the centrally acting and abused form of the drug).
13                 We systemically administer a centrally acting anesthetic photoaffinity ligand in mice
14                             Treatment with a centrally acting angiotensin-converting enzyme inhibitor
15 ed that rilmenidine, a well tolerated, safe, centrally acting anti-hypertensive drug, could induce au
16 I(1)-imidazoline receptor with moxonidine, a centrally acting antihypertensive, increased by greater
17         Likewise, systemic injections of the centrally acting beta-adrenoceptor antagonist propranolo
18                                        While centrally acting cannabinoid agonists are known to produ
19                                              Centrally acting cannabinoids are well known for their a
20 s marketing and clinical withdrawal of other centrally acting CB1 antagonists; however, the design st
21                  Clinical development of the centrally acting CB1 inverse agonist otenabant (1) was h
22  precluded clinical use of first-generation, centrally acting CB1 receptor blockers.
23 this effect is generally inhibitory, we used centrally acting cholinergic agonists to augment central
24 irst of all on the cell cycle machinery with centrally acting cyclin-dependent kinases (CDKs) and the
25 reatment algorithms using various classes of centrally acting drugs, including antidepressants and an
26 findings suggest that clozapine, and related centrally acting drugs, might be highly effective for re
27                                              Centrally acting drugs, such as phentermine-topiramate a
28      The present study showed that leptin, a centrally acting hormone secreted by adipocytes, rescued
29                                         This centrally acting IL-1beta has recently been shown to imp
30 suggest a potential neuroprotective role for centrally acting L-type calcium channel blockers of the
31 ained CNS penetration, making it a promising centrally acting MOR antagonist candidate.
32  Herein, we report our efforts on developing centrally acting MOR antagonists by structural modificat
33 matory pathway is of interest for the use of centrally acting muscarinic cholinergic enhancers as ant
34                                          The centrally acting muscarinic cholinergic receptor agonist
35 ide, has led to the discovery of the potent, centrally acting muscle relaxant (E)-2-(4,6-difluoro-1-i
36 antiinflammatory and analgesic agent without centrally acting muscle relaxant activity.
37 s rats produced by systemic injection of the centrally acting N-methyl-D-aspartate (NMDA) receptor io
38 up-regulation in the dorsal root ganglion of centrally acting neuromodulators and simultaneously in t
39                        Pretreatment with the centrally acting nicotinic antagonist, mecamylamine (1 m
40 differential contribution of peripherally or centrally acting NMU system.
41  ACE inhibitors, particularly those that are centrally acting, on psychiatric symptoms in patients wi
42                          Pain treatment with centrally acting opiates is limited by tolerance.
43 nation of a peripherally acting NSAID with a centrally acting opioid drug is found to be more effecti
44 be less pronounced for peripherally than for centrally acting opioids, which provides a promising per
45  developed; one such agent, tapentadol, is a centrally acting oral analgesic that possesses a combine
46 Recently, we discovered a new glucogenic and centrally acting orexigenic hormone - asprosin.
47 forming a glucogenic function, asprosin is a centrally acting orexigenic hormone that is a potential
48                               Sibutramine, a centrally acting reuptake inhibitor of monoamines, and o
49 this study was to test whether moxonidine, a centrally acting sympathoinhibitory agent, can lead to a
50                     Metabolically stable and centrally acting thyrotropin-releasing hormone (TRH) ana
51 earlier is applied to provide an overview of centrally acting treatment strategies, both psychologica
52 refore, our design afforded a novel lead for centrally acting TRH analogues.