ライフサイエンスコーパス: centric

1 RNAs bound to a protein of interest (protein-centric).

2 which is peptide-centric instead of protein-centric.

3 n countries and quantitative studies were UK centric.

4 of liberal bias in the field seems American-centric.

5 olarized by stress even when the material is centric.

6 ion and lift force during a dexterous object-centric action in a large sample of male and female huma

7 terizing the neural circuitry driving object-centric actions.

8 COL17A1 in HFSCs orchestrates the stem cell-centric aging program of the epithelial mini-organ.

9 at couldn't be recovered by traditional gene-centric analyses.

10 s integration of blockchain with AI for data-centric analysis and information flow, its current limit

11 ion (LO) is by definition a process, process-centric analysis and visualization of this important pha

12 ion would be hidden from a conventional gene-centric analysis of gene expression.

13 threshold, and sequencing depth impact gene-centric analysis of human fecal microbiomes when using D

14 Genome-wide and chromosome-centric analysis of structural variation (SV) events hig

15 Subsequent peptide-centric analysis, through proteolytic digestion of C9 an

16 hy to be uncovered by high-dimensional, data-centric analysis.

17 e evaluation of the network-centric and gene-centric analytic methods showed that mlDNA substantially

18 t data on pesticide mineralization, the gene-centric and biomass-based models performed equally well.

19 ce, which allows users to pivot between gene-centric and cancer type views.

20 n cascades are described taking intervention-centric and client-centric perspectives to look at suppl

21 ular, there is ongoing dissent between motor-centric and cognitive accounts whether premotor cortex o

22 ification of Diseases, Ninth Revision (ICD9)-centric and disease name centric views of disease inform

23 Two complementary approaches, i.e. structure-centric and function-centric, are presented here to show

24 Comparative evaluation of the network-centric and gene-centric analytic methods showed that ml

25 We applied the method in cell-centric and gene-centric modes to isolate cDNA fragments

26 y will eventually require an even less brain-centric and mechanistic cognitive neuroscience that focu

27 anization that we show is OFF-dominated, OFF-centric and runs orthogonal to ocular dominance columns.

28 edict binding sites (GRaSP), a novel residue centric and scalable method to predict ligand-binding si

29 structures; and (2) overhaul of its hospital-centric and treatment-based delivery system.

30 nt algorithms for cardiac arrest are rescuer centric and vary little from patient to patient.

31 ze proteins bound to an RNA of interest (RNA-centric), and those that examine RNAs bound to a protein

32 tific psychology, 2) considerably less brain-centric, and 3) nosologically more skeptical and less do

33 ion genetics "follows" genes, is replication-centric, and is concerned with vertically consistent gen

34 CARD is ontologically structured, model centric, and spans the breadth of AMR drug classes and r

35 or example, we demonstrated that the context-centric approach can be used to identify potential molec

36 In future work, the edge-centric approach could be useful for identifying novel b

37 Although useful, this spectrum-centric approach requires a full evaluation of all possi

38 In other words, the RNA ligand-centric approach taken here overcomes a problematic mole

39 Here, we present PepQuery, a peptide-centric approach that focuses on only novel DNA or prote

40 from network neighbors' and (iii) a context-centric approach to 'find context-associated hub genes',

41 mplementary network methods: (i) a phenotype-centric approach to 'find new members for a pathway'; (i

42 find new members for a pathway'; (ii) a gene-centric approach to 'infer functions from network neighb

43 s bottom-up perspective provides a materials-centric approach to bioink design for 3D bioprinting.

44 In this paper, we present a graph-centric approach to improving metagenome-guided peptide

45 ial to the promotion of a successful patient-centric approach to surgical care.

46 We present a function-centric approach using deep mutational scanning to eluci

47 We discuss the feasibility of the peptide-centric approach which was tested on several quantitativ

48 mon characteristics to evaluate a drug (drug-centric approach) and optimal treatment based on curated

49 drug combinations for each patient (patient-centric approach).

50 ces and implemented an intervention: a donor-centric approach, including employee education, office d

51 ical mechanisms, rather than a strictly gene-centric approach, will provide grounds for a different a

52 athway mapping approaches, molecular network centric approaches and approaches that represent biologi

53 To supplement gene-centric approaches and provide a more reliable proxy for

54 his resource underscores the value of genome-centric approaches for revealing genomic properties of u

55 Indeed, network-centric approaches have proven to be helpful for finding

56 atforms could play dominant roles in patient-centric approaches of treatment in the future, potential

57 Unlike gene-centric approaches, pathway-based methods provide a syst

58 l systems, complementing conventional neural-centric architectures.

59 roaches, i.e. structure-centric and function-centric, are presented here to showcase how to leverage

60 In addition to a gene-centric assembly tool, GRASP also serves as a homolog se

61 Enhanced training for clinicians in patient-centric asthma care may be needed.

62 brane tubules in hepatoma cells and along LD-centric autophagic membranes.

63 Altogether, our data reveal an emergent Kap-centric barrier mechanism that may underlie mechanistic

64 complements the traditional, dark-reactions-centric biochemical model of photosynthesis.

65 genes involved in key keratinocyte and skin-centric biological processes.

66 Analysis of tumor-centric biomarkers showed that mutational processes (sig

67 t the primer terminus opposite cytosine, DNA centric changes lead to a clash between O8 of 8-oxoG and

68 overcome to develop potent and selective RNA-centric chemical probes.

69 Here we present HiChIP, a protein-centric chromatin conformation method.

70 n assay) and HiChIP (high-throughput protein centric chromatin) performed on a subset of hearts.

71 Glio (Avastin in Glioblastoma; NCT00943826), CENTRIC (Cilengitide, Temozolomide, and Radiation Therap

72 For mono-centric cities, we propose a linear combination of logar

73 barriers to realizing the premise of patient-centric clinical trials.

74 Telomere-centric CNR following recursive WGD in plants is also im

75 We describe a need for an endocrine-centric component for overall health assessments and pro

76 uster analysis is a core task in modern data-centric computation.

77 In recent years, the patient-centric concept has been emphasized.

78 ld also be directed to improve other patient-centric concerns, such as functional capacity and qualit

79 nce of food-web structure through a consumer-centric consideration of diet choice.

80 tablish a continuum under a mechanism of Kap-centric control.

81 latively low-cost per sample and broad, gene-centric coverage of CpGs across the human genome, Illumi

82 mportant but not yet standard to combine RNA-centric data and analysis tools with other types of expe

83 nderlying operons; (ii) an integrated operon-centric data resource that provides not only operons for

84 orm for the processing of multimodal patient-centric data.

85 the assay library used for targeted, peptide-centric, data analysis.

86 Therefore, we aimed to develop a molecule-centric database featuring CKD-related experiments from

87 ped the PlantSEED, an integrated, metabolism-centric database to support subsystems-based annotation

88 Moreover, a peptide-centric database was first introduced to analyze protein

89 gene calls using protein-, virus- and phage-centric databases.

90 These results inform shared, patient-centric decision making on the ideal duration of the use

91 itask approach, which explicitly models gene-centric dependencies across multiple and distinct genomi

92 We demonstrate that accounting for the gene-centric dependencies enables leveraging information from

93 The gene-centric design of VIRGO and VOG provides an easily acces

94 (ATOM) near-eye display based on the "human-centric design" principle.

95 es are a promising design paradigm for human-centric devices(1,2) and systems required to interact ge

96 With an ontology that represents patient-centric dialogue to communicate health information, we h

97 he recently available genome sequence of the centric diatom Cyclotella cryptica to analyze gene seque

98 isolation of stable supercomplexes from the centric diatom Thalassiosira pseudonana was achieved.

99 The CCM(s) present in the marine-centric diatom, Thalassiosira pseudonana, were studied i

100 amounts of trimeric FCPa complexes with the centric diatom-specific Lhcx protein, Lhcx6_1, as subuni

101 Thus, the antenna organization of centric diatoms, as well as the distribution of differen

102 empt to classify two HCC patients with multi-centric disease using the recall-rates of somatic mutati

103 tomic-scale control of inversion-preserving (centric) displacements.

104 e ExAC browser provides gene- and transcript-centric displays of variation, a critical view for clini

105 The Omegaven trial is a multi-centric, double-blind, randomized, placebo- controlled t

106 Target-centric drug development strategies prioritize single-ta

107 Our findings suggest that a network-centric drug discovery approach is a promising strategy

108 ected with high predictive value in amygdala-centric emotion circuits at a surprisingly young age.

109 omotion and manipulation in natural or human-centric environments.

110 e that has partially rejected orthodox, gene-centric evolutionary theory.

111 Moreover, contrary to drift-centric expectation, variation in diverse wild yeast iso

112 eadout supporting pursuit of transactivation-centric experimental designs for high-throughput functio

113 Our findings highlight how gene-centric experiments (such as systematic knock-out or sil

114 ng human pathogens, which has led to a human-centric focus in this vector system.

115 nctional screen provides a paradigm for gene-centric follow up of GWAS for a variety of human disease

116 ajority of the elevated proteins were muscle centric followed by cell adhesion, extracellular matrix

117 on of nonnative stabilization against native-centric forces is conceptualized as frustration.

118 l PFC-based models with an emerging thalamus-centric framework for the mechanistic understanding of w

119 Our work presents a general, data-centric framework that could potentially be used to addr

120 Here, we describe a plasmid-centric framework that makes it computationally feasible

121 tured clusterings by proposing a new element-centric framework: elements are compared based on the re

122 Our hope is that such trust-centric frameworks provide a sustainable solution that r

123 Most domain-centric function prediction methods depend on accurate d

124 nd from previous work, we constructed an RHO-centric functional map, allowing pleiotropic and epistat

125 Looking ahead, patient centric functional screening in primary cells will likel

126 Patients with HCV reinfection in the multi-centric GECCO cohort were compared to patients in whom n

127 Patients with HCV reinfections in the multi-centric GECCO cohort were compared to patients in whom n

128 This framework incorporates three function-centric gene-set analysis strategies: a meta-analysis of

129 We analyzed the expression of 632 immune-centric genes in tissue biopsied from implants at weekly

130 trates that IRF4 adopts either SPIB- or BATF-centric genome-wide distributions in related states of p

131 Edge-centric graph-theoretic analysis showed that highly sele

132 ken together, our results revealed an AR-ERG-centric higher-order chromatin structure that drives coo

133 than smaller members, supporting the 'gastro-centric' hypothesis.

134 rs might help improve the efficacy of T cell-centric immunotherapies.

135 in 2010, end-of-life care was more hospital-centric in Belgium, Canada, England, Germany, and Norway

136 somatic variants that drive cancer are 'gene-centric' in that they consider only somatic variants wit

137 quantitative proteomic data which is peptide-centric instead of protein-centric.

138 periphery mediates an early transient hepato-centric insulin action and blunts hypoglycaemia in dogs

139 The method is based on a gene-centric integrative coefficient quantifying to what degr

140 on of erythroid super-enhancers and promoter-centric interactions reveal organizational principles of

141 A genome-centric investigation into sub-optimal diets highlighted

142 vely, resulted in the emergence of pentacene centric Kasha's ideal null exciton, providing novel insi

143 amming language to analyze PTMs from peptide-centric label-free quantitative proteomics data.

144 oach for fostering a constructivist, student-centric learning environment, research on the efficacy o

145 LexExp is an open-source, data-centric lexicon expansion system that generates spelling

146 hid and araphid species and arose within the centric lineage.

147 for Alzheimer's disease (AD) posits a neuron-centric, linear cascade initiated by Abeta and leading t

148 Can "urban-centric" local television news coverage of the COVID-19

149 genomics in clinical context so that patient-centric longitudinal clinical, genomic, and molecular ph

150 izes the information in a gene- or territory-centric manner.

151 actional synthesis rates compared to peptide centric mass isotopomer distribution analysis approaches

152 Glycopeptide-centric mass spectrometry has become a popular approach

153 This study highlights the role of gene-centric matchmaking tools to establish causal links to g

154 Using a gene-centric "matchmaking" system, we were able to identify a

155 ric stress cannot induce a polar response in centric materials; piezoelectricity is, for example, pos

156 ciation is prevalent across a number of node-centric measures and is asymmetrical: disruption to the

157 Using Drosophila, we identify a centriole-centric mechanism that ensures proper proximal end docki

158 bacteria that does not rely on the bacterial-centric mechanisms such as adhesins.

159 r impact on type 2 diabetes using a European-centric meta-analysis comprising 37,293 case and 125,686

160 tudies, PTM information displayed in protein-centric metabolic pathways and groups of proteins that a

161 Here, we use genome-centric metagenomics to recover 17 draft genomes of anam

162 tem can provide a cost-effective and patient-centric method for HCV treatment, including in high-risk

163 complex whereas the state-of-the-art residue-centric method takes 2-5 h on average.

164 Thus, we present an RNA-centric method that enables reliable identification of R

165 e present oncodomain hotspots, a new 'domain-centric' method for identifying clusters of somatic muta

166 it proteases as an example, we review native-centric methods for simulating the folding of large prot

167 GRaSP outperformed six other residue-centric methods, including the one considered as state-o

168 n compared with five state-of-the-art pocket-centric methods, which we consider a significant result,

169 y using plant-centric rather than atmosphere-centric metrics from Earth system models (ESMs).

170 ng the concept that purely tumour epithelium-centric metrics of aggressiveness may be incomplete and

171 This gene-centric model has shaped the field of cancer biology and

172 argument will be presented that the mutation-centric model of cancer suggests unrealistic solutions t

173 that the intermediates predicted by a native-centric model of cotranslational folding account for the

174 Our gene-centric model provides an effective approach for exploit

175 g yeast that is incompatible with this Wpl1p-centric model.

176 ith genetic data, we developed a novel "gene-centric" model and compared model variants of differing

177 Coarse-grained simulations employing native centric models are capable of sampling the entire energy

178 Contrary to origin-centric models of segregation, which predict distinct dy

179 applied the method in cell-centric and gene-centric modes to isolate cDNA fragments from scRNA-seq l

180 nsfection (RET)) has established an oncogene-centric molecular classification paradigm in this diseas

181 Innovative patient-centric, molecular pathology-driven clinical trial appro

182 rphism in microRNA target sites (poly-miRTS)-centric multistage meta-analysis for lumbar spine (LS)-,

183 PTM-centric network analyses combine PhosphoSitePlus, iPTMne

184 Network neuroscience has relied on a node-centric network model in which cells, populations and re

185 In this study, we developed an edge-centric network model that generates constructs 'edge ti

186 but instead is organized as a protein chain-centric network of sequence and structural homologues.

187 seases that are the focal points in the race-centric networks and of particular clinical importance.

188 A donor-centric OPO-managed DMV experience increases FPA registr

189 the function of signalling pathways, module-centric optimisation algorithms, whose aim is to identif

190 We classified outcomes as patient-centric or not patient-centric using a prespecified defi

191 of a sustainable, low-cost, African American-centric organ donation educational video.

192 previous works, our study reveals a pathway-centric organization of 3D-nucleome, whereby, functional

193 lating, for instance, between mono- and poly-centric organization.

194 mologous chromosomes, which argues for multi-centric origin of respective HCCs.

195 Functional status is a key patient-centric outcome, but there are little data on whether fu

196 o make recommendations for measuring patient-centric outcomes in interventions for motor improvement

197 Patient-centric outcomes that provide insight into the relative

198 Patient-centric outcomes-such as adverse events (n = 19; 15%), t

199 Our structural membrane-centric outlook underscores the spatiotemporal principle

200 The atmosphere-centric Palmer Drought Severity Index predicts future in

201 ffects, thus departing from the cytotoxicity-centric paradigm previously assigned to HDACi.

202 Because of the stream-centric paradigm, memory requirements are minimized (oft

203 pothesis, we developed and applied a residue-centric patient presentation score to 9,176 cancer patie

204 spindle microtubules in a unique chromosome-centric pattern, in the vicinity of overlapping microtub

205 al and functional experiments from a network-centric perspective by showing that global properties of

206 n risk taking became apparent: the procedure-centric perspective described how surgeons viewed their

207 viewed their colleagues whereas the surgeon-centric perspective described how surgeons viewed themse

208 The plant-centric perspective has equated plant nutrient limitatio

209 e, these demonstrations offer an information-centric perspective on the high-throughput synthesis and

210 tumor angiogenesis and metabolism from a HIF-centric perspective, considering alterations in the hypo

211 profiles, common artifacts for CLIP and RNA-centric perspectives on RBP activity.

212 ribed taking intervention-centric and client-centric perspectives to look at supply, demand, and effi

213 tal marrow and lymphoid irradiation in multi-centric phase 2-3 trials.

214 cture, as opposed to the traditional cluster-centric philosophy.

215 ted autonomous DPS device may enable patient-centric plasma sampling through minimally invasive finge

216 arger proteins has been studied using native-centric potential functions, but such models omit the po

217 Term-centric prediction of experimental annotations remains e

218 Notably, elderly-centric programmes vaccinating from 65-75 years and abov

219 Complex-centric proteome profiling captures most proteins in com

220 of native protein complex analysis (complex-centric proteome profiling).

221 native mass spectrometry and (glyco)peptide-centric proteomics.

222 eport that catalytically similar single-atom-centric Pt sites are formed by binding to sodium ions th

223 urrently supports tools to visualize protein-centric PTM networks, quantitative phosphorylation site

224 -mass spectrometry, particularly for peptide-centric quantification dealing with post-translational m

225 etrieve significant peptides lost in protein-centric quantification for further downstream analysis.

226 We show that peptide-centric quantification has several advantages over prote

227 strategy provides high accuracy as an MS(1)-centric quantification method, avoiding the ratio compre

228 sion, providing excellent accuracy for MS(1)-centric quantification.

229 at this reduction is captured by using plant-centric rather than atmosphere-centric metrics from Eart

230 nctional classifier called InterPro2GO, gene-centric read assembly, principal coordinate analysis of

231 )-containing heterochromatin is located near centric regions of chromosomes and regulates DNA-mediate

232 ntences (and their documents) conveying gene-centric relationships of interest to a scientist.

233 Our results reveal an important metabolism-centric role of USP13, which may lead to potential thera

234 lysis plan, meta-analyses, and weighted gene-centric scores.

235 d for discovery proteomics based on spectrum-centric scoring can be adapted to large-scale DIA experi

236 riments that have been analyzed with peptide-centric scoring strategies, and we provide guidance on t

237 dent acquisition (DIA) combined with peptide-centric scoring, as exemplified by the technique SWATH-M

238 Ferret successfully retrieved relevant gene-centric sentences from PubMed records.

239 The former (peri)centric sequences left behind shrunk dramatically in siz

240 n inputs and parameters, the light-reactions-centric, SIF-based biophysical model complements the tra

241 We have combined sequence-sensitive native centric simulations with small-angle X-ray scattering an

242 ation results for blood pressure using exome-centric single-variant and gene-based tests identified 3

243 s such as high-resolution displays and human-centric soft electronics.

244 in CCMP470, previously annotated as a radial centric species related to Leptocylindrus danicus, as an

245 The diatoms include both centric species, which may have radial or polar symmetry

246 successful, could supplement the cancer cell-centric standard of care therapies in order to fully mee

247 m has thus far been addressed from a protein-centric standpoint; however, protein-coding regions only

248 ates with the novel aggregation method, cell-centric statistics (CCS).

249 We used data from a socio-centric study of sexual behaviour in Malawi to quantify

250 ring common pathways are merged into pathway-centric supermodules and a Cytoscape plug-in (MetaDCNExp

251 response exhibit breaking of the macroscopic centric symmetry through inhomogeneity induced by the hi

252 Further, components from these nucleotide-centric systems have been utilized in several other syst

253 fer robust recording methods with less human-centric tasks, while humans provide complex behavior wit

254 rom those found in classical, model organism-centric textbooks.

255 tive pennate (Phaeodactylum tricornutum) and centric (Thalassiosira pseudonana) diatom.

256 Adopting a more patient-centric therapeutic approach that incorporates applied g

257 An alternative to disease-centric therapeutic approaches is that of 'geroscience',

258 are expected to inspire development of lipid-centric therapeutic approaches targeted toward its membr

259 current as well as unexplored EC metabolism-centric therapeutic avenues are discussed.

260 and computational tools for evaluating water-centric thermodynamics are reviewed.

261 ner, including its re-engineering to be gene-centric to enable easier sharing of evidence among ortho

262 ation of the aging female brain from glucose centric to utilization of auxiliary fuel sources that in

263 re we present PECAN, a library-free, peptide-centric tool that robustly and accurately detects peptid

264 lar dynamics simulations as well as fragment-centric topographical mapping of binding interfaces, we

265 This p53-centric transcriptional network and its associated pheno

266 m (ES) cell pluripotency is governed by OCT4-centric transcriptional networks.

267 and demonstrated that phylogenetic and gene-centric transformations of this model can be translated

268 has been a big obstacle, mitigating a leptin-centric treatment of obesity.

269 microbiome associations display specific age-centric trends.

270 type in ADAPTABLE (Aspirin Dosing: a Patient-Centric Trial Assessing Benefits and Long-Term Effective

271 led the ADAPTABLE (Aspirin Dosing: A Patient-centric Trial Assessing the Benefits and Long-term Effec

272 basis toward a more quantitative and network-centric understanding of the complex physiology and vers

273 d outcomes as patient-centric or not patient-centric using a prespecified definition.

274 fy common and rare psoriasis-associated gene-centric variation.

275 A pathway-centric view acknowledges the heterogeneity between geno

276 In this review, we provide a virus-centric view and novel insights into HPV-positive head a

277 This HSC-centric view is based largely on studies showing that HS

278 These results challenge a Z-ring-centric view of bacterial cytokinesis and identify cell

279 paradigm, we provide a transcription-factor-centric view of chromatin reorganization and its associa

280 ock, with a focus on (a) an emerging network-centric view of clock architecture, (b) mechanistic insi

281 ing of plastid integration and favors a host-centric view of endosymbiosis.

282 ld of autoinflammation is moving from a gene-centric view of innate immune-mediated disease towards a

283 A mean-centric view of populations, whereby a change in the mea

284 tive group functioning, they adopt a Western-centric view of the relationship of the individual to th

285 embrane proteins have long adopted a protein-centric view regarding the determinants of membrane prot

286 lostery is principally shaped by a structure-centric view, which makes it difficult to understand the

287 This ''protein-centric" view is increasingly challenged by evidence for

288 r sensing systems and argue that a "location-centric" view of complement evolution could logically ju

289 mass spectrometry (ChIRP-MS), we took an RNA-centric viewpoint of flaviviral infection and identified

290 However, the resource-centric viewpoint, where species adjust their behaviour

291 nth Revision (ICD9)-centric and disease name centric views of disease information.

292 Our variant-centric visualization clarifies the geographic patterns

293 ism, and each has been interpreted in autism-centric ways (psychoanalytic interpretations of pronoun

294 We introduce STAMPS, a pathway-centric web service for the development of targeted prot

295 The platform provides either a target-centric workflow to identify diseases that may be associ

296 ociated with a specific target, or a disease-centric workflow to identify targets that may be associa

297 transition between these target- and disease-centric workflows.

298 ure development includes providing a variant-centric XML archive and a web page for details of SCV su

299 nVar) accession numbers found in the variant-centric XML file.

300 ClinVar's variant-centric XML had its production release in April 2019.