ライフサイエンスコーパス: centrosomal

1 p16 is also associated with suppressing centrosomal aberrations in breast cancer; however, the r

2 nally, Aurora-A(-/-) keratinocytes displayed centrosomal abnormalities that included centrosomes loca

3 cell mitotic protein TACC3 leads to enhanced centrosomal abnormalities, activation of death programs,

4 Pathogenic LRRK2 causes the centrosomal accumulation not only of phosho-RAB8 but als

5 ated ciliogenesis defects correlate with the centrosomal accumulation of both phospho-RAB8 and phosph

6 ited by the mutant integrin by promoting the centrosomal accumulation of gamma-tubulin.

7 Here, we show that SDCCAG8 regulates centrosomal accumulation of pericentriolar material and

8 Our previous studies indicate that the centrosomal accumulation of phosphorylated RAB8A causes

9 ich we show here are required for GFP-Rabin8 centrosomal accumulation, supporting a role for the TRAP

10 pears to be associated with decreased Rabin8 centrosomal accumulation.

11 ng both in vitro and in vivo assays to study centrosomal actin nucleation as cells pass through mitos

12 observe that Net1 expression is required for centrosomal activation of p21-activated kinase and its d

13 Disruption of centrosomal activity or downregulation of the centriolar

14 The cancer-associated, centrosomal adaptor protein TACC3 (transforming acidic c

15 ry breaking early in the cell cycle, whereas centrosomal AIR-1 instructs polarity initiation thereaft

16 on by BMI1 exerts several effects, including centrosomal amplification and aneuploidy, antiapoptosis,

17 tumor growth in murine xenograft models, and centrosomal amplification induced by its overexpression.

18 lei, formation of anucleated daughter cells, centrosomal amplification, and aneuploidy.

19 istically significant increases (P < .05) in centrosomal amplification, micronuclei, and micronuclei

20 e, were examined for genotoxicity, including centrosomal amplification, micronuclei, and micronuclei

21 pressor p53 prevents genomic instability and centrosomal amplification.

22 ancer cells that may lead to chromosomal and centrosomal amplifications.

23 ex (gamma-TuRC) is an essential regulator of centrosomal and acentrosomal microtubule formation, yet

24 Certain phenotypes attributable to centrosomal and cell polarity functions could not be res

25 t the temporally orchestrated destruction of centrosomal and ciliary proteins is a necessary antecede

26 and mass spectrometry of interactors of the centrosomal and ciliopathy protein, CEP19, we identify C

27 suggest that Nin plays a supportive role in centrosomal and extracentrosomal microtubule organizatio

28 mediated depletion of Cyclin F in G2 induces centrosomal and mitotic abnormalities, such as multipola

29 ctedly, CN shows SLiM-dependent proximity to centrosomal and nuclear pore complex (NPC) proteins-stru

30 ;Nedd9(-/-) cells have increased cell cycle, centrosomal, and mitotic defects, phenotypes compatible

31 A centrosomal array of microtubules subjected to dynein pu

32 CA-1 acts with gamma-tubulin to assemble non-centrosomal arrays in multiple tissues and highlight fun

33 Many cells contain non-centrosomal arrays of microtubules (MTs), but the assemb

34 nt, Spc42, resulted in lethality and reduced centrosomal assembly.

35 f-function mutations predominantly affecting centrosomal-associated proteins, but the multiple roles

36 ne width was broadened by attenuation of the centrosomal asters but was not affected by MP-GAP inhibi

37 the relative contributions of RhoA flux and centrosomal asters in controlling RhoA zone dimensions.

38 ent relative to the apicobasal axis, loss of centrosomal attachment, and apical stabilization.

39 The centrosomal Aurora-A kinase (AURKA) regulates mitotic pr

40 f motor proteins, plays an essential role in centrosomal bundling in cancer cells, but its function i

41 In summary, we characterize a unique centrosomal Ca(2+) signal as a functionally essential in

42 Local buffering of the centrosomal Ca(2+) signals, by flash photolysis of the c

43 Accordingly, centrosomal CaMKIIbeta signaling mediates the ability of

44 Finally, disruption of the centrosomal cAMP microdomain by local displacement of PD

45 e progression relies on unique regulation of centrosomal cAMP/PKA signals.

46 r, we uncover a critical requirement for the centrosomal casein kinase I delta (CKIdelta) in centroso

47 sion from the centrosome, thereby inhibiting centrosomal Cdc20-APC activity and triggering the transi

48 Distinct mutations in the centrosomal-cilia protein CEP290 lead to diverse clinica

49 iary length in control MEFs, suggesting that centrosomal CK1delta has a role in ciliogenesis.

50 y of a prototype small molecule inhibitor of centrosomal clustering and strongly support the further

51 ve of griseofulvin, as a potent inhibitor of centrosomal clustering in malignant cells.

52 h associates with spindle poles and promotes centrosomal clustering, is essential for formation of a

53 LRRK2-mediated centrosomal cohesion and ciliogenesis alterations are ob

54 These data suggest that the LRRK2-mediated centrosomal cohesion and ciliogenesis defects are distin

55 us and highlight the possibility that either centrosomal cohesion and/or ciliogenesis alterations may

56 ut also of phospho-RAB10, and the effects on centrosomal cohesion are dependent on RAB8, RAB10 and RI

57 accumulation of phosphorylated RAB8A causes centrosomal cohesion deficits in dividing cells, includi

58 w that both RAB8 and RAB10 contribute to the centrosomal cohesion deficits.

59 The Pcnt gene encodes a large centrosomal coiled-coil protein that has been implicated

60 mutated in 3M short stature syndrome, form a centrosomal complex that regulates CUL9 and its substrat

61 t mechanism that involves degradation of the centrosomal component CEP192.

62 TRIM37 knockout cells formed ectopic centrosomal-component foci that suppressed mitotic defec

63 Centrosome reduction is the decrease in centrosomal components during spermatid differentiation

64 r results suggest conservation of eukaryotic centrosomal components in plant cells.

65 asma gondii, TgCep250, in connecting the two centrosomal cores and promoting their structural integri

66 This delay suppresses polarization by non-centrosomal cues, which can otherwise trigger premature

67 t conclusive evidence that DVL regulates the centrosomal cycle.

68 , in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 and advances entry into mitosi

69 mogenesis by enabling CLL cells to cope with centrosomal defects acquired during malignant transforma

70 es organize the bipolar mitotic spindle, and centrosomal defects cause chromosome instability.

71 pic RGPs, as well as those in the VZ, with a centrosomal deficit exhibited prolonged mitosis, p53 upr

72 copy, and live-cell imaging we discover that centrosomal delivery of Polo-like kinase 1 (Plk1) and Au

73 ulates a variety of cell functions including centrosomal duplication, cell cycle control, and apoptos

74 s microtubule disorganization and release of centrosomal dynactin.

75 ng concept that DNA replication is linked to centrosomal events.

76 nerated against isolated nucleolini revealed centrosomal forerunners in the oocyte cytoplasm.

77 n) expresses two major protein variants: the centrosomal form (CnnC) and a non-centrosomal form in te

78 iants: the centrosomal form (CnnC) and a non-centrosomal form in testes (CnnT).

79 is by multiple mechanisms, one involving its centrosomal function and another dependent on its intera

80 ex and that this localization regulates both centrosomal function and JAK2 kinase activity, thus cont

81 ions in CDK5RAP2 is associated with impaired centrosomal function and with changes in mitotic spindle

82 te protein PCM1, implicated in autophagy and centrosomal function, alters its dynamics in cells.

83 Our results suggest distinct apoptotic and centrosomal functions of BRCA1 in neural progenitors, wi

84 ng to GABARAP, regulating starvation-induced centrosomal GABARAP delivery to the phagophore.

85 specifically regulate an ATG8 ortholog, the centrosomal GABARAP reservoir, and centrosome-autophagos

86 y reported, we show that loss of B1 enhanced centrosomal gamma-tubulin localization and microtubule n

87 ession results in mislocalized Plk1 and poor centrosomal gamma-tubulin recruitment, potentially contr

88 Removing sDAPs alter the distal border of centrosomal gamma-tubulins, illustrating a new role of s

89 e signature expression correlate with CA and centrosomal gene signature expression in breast tumors.

90 PNL was associated with higher expression of centrosomal genes and with shorter survival.

91 Defects in cilia centrosomal genes cause pleiotropic clinical phenotypes,

92 findings reveal a new function for Arpc1b in centrosomal homeostasis.

93 The detachment between centrosomal inner and outer cores was found in only one

94 m a centrosomal splice form in NPCs to a non-centrosomal isoform in neurons.

95 negatively affects cell division through its centrosomal kinase activity.

96 of Aurora A (AurA) describe it as a mitotic centrosomal kinase.

97 revents NEK2-controlled dissolution of loose centrosomal linker and subsequent centrosomal separation

98 ated protein 1 (C-NAP1), two proteins of the centrosomal linker.

99 la Asl and human CEP152 are required for the centrosomal loading of Plk4 in Drosophila and CPAP in hu

100 wo proteins are dependent on one another for centrosomal localisation.

101 Further, TBK1 is necessary for CEP170 centrosomal localization and binding to the microtubule

102 or human neurodevelopment that promotes CDK2 centrosomal localization and centriole duplication.

103 NTE and first two TPRs) are dispensable for centrosomal localization and function.

104 and C termini of BRCA1 are required for its centrosomal localization and that BRCA1 moves to the cen

105 Here, we show that specific DAs lose their centrosomal localization at the G2/M transition in a man

106 of mitotic lymphoblasts or PBMCs bearing p53 centrosomal localization clearly discriminated among hea

107 isoforms exhibit distinct and complementary centrosomal localization during the cell cycle.

108 to the first quartet cells does not occur if centrosomal localization is bypassed.

109 , and disruption of this motif prevents both centrosomal localization of Cdc13 and the onset of mitos

110 ese results provide strong evidence that the centrosomal localization of CK1delta is required for Wnt

111 complex with CUL7 and regulate the level and centrosomal localization of CUL7, respectively.

112 the level of CCDC8 that is required for the centrosomal localization of CUL7.

113 , Arl2 regulates dynein function and in turn centrosomal localization of D-TACC and Msps.

114 pd2 mutants unable to bind Fzr, we show that centrosomal localization of Fzr is essential for optimal

115 The centrosomal localization of GRK5 is observed predominant

116 sition requires a functional centrosome, and centrosomal localization of numerous proteins, including

117 artic acid phosphomimetic (S490D) results in centrosomal localization of occludin and increases cell

118 ow that phosphorylation is required only for centrosomal localization of p150(Glued) and does not aff

119 ediated by a 20 amino acid domain termed the centrosomal localization sequence (CLS), and expression

120 CK1delta catalytic activity and centrosomal localization signal (CLS) are required to re

121 Here we identify a modular centrosomal localization signal (CLS) localizing cyclin

122 Deletion analysis mapped the centrosomal localization signal (CLS) of CK1delta to its

123 ntriolar satellites normally restricts their centrosomal localization.

124 ated multimerization, is essential for DVL's centrosomal localization.

125 Both arrestins co-localized with the centrosomal marker gamma-tubulin during interphase and m

126 Non-centrosomal microtubule arrays assemble in differentiate

127 NOCA-1 contributes to the assembly of non-centrosomal microtubule arrays in multiple tissues.

128 red a novel role for PAR-6 in organizing non-centrosomal microtubule arrays in the epidermis.

129 , we investigate the organization of the non-centrosomal microtubule arrays present in the epidermis

130 Understanding the mechanisms of centrosomal microtubule nucleation is, however, constrai

131 Our data indicate that, through increased centrosomal microtubule nucleation, centrosome amplifica

132 size, and we recently found evidence for non-centrosomal microtubule nucleation.

133 oadly, illuminates mechanisms regulating non-centrosomal microtubule nucleation.

134 microtubule cytoskeleton that grows from non-centrosomal microtubule organising centres (ncMTOCs) alo

135 ular zone, which reveals the pivotal role of centrosomal microtubule organization in enabling cells t

136 th PAR-6, we propose that PAR-6 promotes non-centrosomal microtubule organization through localizatio

137 Non-centrosomal microtubule organizing centers (MTOCs) direc

138 solely by repetitive "search and capture" of centrosomal microtubule plus ends.

139 The switch from centrosomal microtubule-organizing centers (MTOCs) to no

140 Non-centrosomal microtubule-organizing centres (ncMTOCs) hav

141 member of the XMAP215 family-to assemble non-centrosomal microtubules and does so independently of th

142 on, which may function to tune the levels of centrosomal microtubules during passage through mitosis.

143 When kinetochore capture of centrosomal microtubules is not used, the polar ends of

144 Hence, we propose that non-centrosomal microtubules organized by epidermal junction

145 The finding of inequality in the centrosomal microtubules revealed by these small molecul

146 iated by the plus-end kinesin KIF16B and non-centrosomal microtubules, and its delivery to the apical

147 tein is necessary and sufficient to organize centrosomal microtubules, and promote their nucleation a

148 crotubule interactions among male pronuclei, centrosomal microtubules, and the animal pole, but not t

149 Our interpretation is that capture of centrosomal microtubules-when deployed-is limited to ear

150 a corresponding reduction in the density of centrosomal microtubules.

151 he posttranscriptional regulation of a model centrosomal mRNA, centrocortin (cen).

152 sent the first theoretical model for the non-centrosomal MT cytoskeleton in Drosophila oocytes, in wh

153 mes and the depletion of Arl4D resulted in a centrosomal MT nucleation defect.

154 MT organizing center, the regulation of non-centrosomal MT polarity is poorly understood.

155 Here, we use the robust loss of centrosomal MTOC activity in the epidermis to identify t

156 Although hyperactive centrosomal MTOC activity is a hallmark of some cancers,

157 regulation of these complexes drives loss of centrosomal MTOC activity.

158 Depletion of the non-centrosomal MTOC protein GM130 reduced PCa cell prolifer

159 icrotubule-organizing centers (MTOCs) to non-centrosomal MTOCs during differentiation is poorly under

160 is for this mitochondrial MTOC and other non-centrosomal MTOCs has not been discerned.

161 ation of MT assembly and organization of non-centrosomal MTOCs.

162 Although centrosomal MTs are organized with plus-ends away from t

163 ule, reveal that the anchoring of apical non-centrosomal MTs at apical junctions is polarized, observ

164 Our data indicate that centrosomal MTs complement Golgi self-organization for p

165 question of whether Golgi assembly requires centrosomal MTs or can be self-organized, relying on its

166 Increased DVL levels, in contrast, sequester centrosomal NEK2 and mimic monopolar spindle defects ind

167 subunit-associated protein 2 (CDK5RAP2) and centrosomal Nek2-associated protein 1 (C-NAP1), two prot

168 clude that cell confinement controls nuclear-centrosomal orientation and lumen initiation during 3D e

169 s recruitment is dependent on hSAS-6 but not centrosomal P4.1-associated protein (CPAP) and CP110.

170 Centrosomal PCM1 immunoreactive area was smaller in Cys7

171 We quantified centrosomal PCM1 immunoreactivity in STG glia of 81 cont

172 in vivo that DISC1 coding variants modulate centrosomal PCM1 localization, highlight a role for DISC

173 sonance energy transfer reporters shows that centrosomal PDE4D3 modulated a dynamic microdomain withi

174 e identify TRIM37 as a negative regulator of centrosomal pericentriolar material.

175 We previously identified the centrosomal phosphoprotein NDE1 as a negative regulator

176 AKAP9-anchored, centrosomal PKA showed a reduced activation threshold as

177 of Plk1 in zebrafish embryos illustrates how centrosomal Plk1 underlies mitotic spindle assembly.

178 ay in interphase cells, and depletion of its centrosomal pool entails microtubule disorganization.

179 ft140-deleted collecting ducts showed normal centrosomal positioning and no misorientation of the mit

180 l a critical role for SDCCAG8 in controlling centrosomal properties and function, and provide insight

181 d to depletion of multiple subunits from the centrosomal proteasome.

182 Among them, we confirmed Ser-78 in centrosomal protein 131 (CEP131, also known as AZI1) as

183 ing a recently identified ciliopathy protein centrosomal protein 164 (CEP164).

184 ature centrioles (basal bodies) and requires centrosomal protein 164kDa (Cep164), a component of dist

185 s) and recruitment of the insulator proteins Centrosomal Protein 190 kD (CP190) and Modifier of mdg4

186 2), potently and selectively binds the human centrosomal protein 250 (CEP250), resulting in disruptio

187 Mutations in the centrosomal protein 290 (CEP290) gene cause various cili

188 The gene coding for centrosomal protein 290 (CEP290), a large multidomain pr

189 Mutations in the gene centrosomal protein 290 kDa (CEP290) cause an array of d

190 Mutations of the centrosomal protein 290 kDa (CEP290) lead to distinct cl

191 The normal cellular level of centrosomal protein 4.1-associated protein (CPAP), achie

192 Centrosomal protein 4.1-associated protein (CPAP), centr

193 CPAP (centrosomal protein 4.1-associated protein) was previous

194 Centrosomal protein 55 (Cep55), which is localized to th

195 n, the membrane glycoprotein dysadherin, the centrosomal protein 68 (Cep68), and the cytoskeletal ada

196 hts the article by Shi et al that identified centrosomal protein 70 as a key mediator of breast cance

197 the article by Li et al that identified the centrosomal protein 72 as a biomarker for prognosis of u

198 -1G>A and c.534delT) in CEP78, which encodes centrosomal protein 78, in six individuals of Jewish anc

199 Selective removal of centrosomal protein 83 (CEP83) eliminates these distal a

200 age proteins Fas-binding factor 1 (FBF1) and centrosomal protein 83 (CEP83), which we show here are r

201 CEP57 is a centrosomal protein and is involved in nucleating and st

202 es and basal bodies via interaction with the centrosomal protein CAP350 and demonstrate that CYLD mus

203 We further show that downregulation of the centrosomal protein Cep120 impairs microtubule organizat

204 The centrosomal protein Cep135 localizes to this cartwheel,

205 TBK1 binds to the centrosomal protein CEP170 and to the mitotic apparatus

206 sensor through proline hydroxylation of the centrosomal protein Cep192.

207 microcephaly- and primordial dwarfism-linked centrosomal protein CEP215 has been implicated in this p

208 the result of mutations in the gene encoding centrosomal protein CEP290.

209 Tubulin, by interacting with the centrosomal protein CPAP, negatively regulates CPAP-depe

210 Cep55 is a relatively novel member of the centrosomal protein family.

211 ALMS1 encodes a centrosomal protein implicated in the assembly and maint

212 motifs of TRMs are found in CAP350, a human centrosomal protein interacting with FOP, and the C-term

213 er region of the CEP72 gene, which encodes a centrosomal protein involved in microtubule formation, h

214 entrosomin (cnn), an essential gene encoding centrosomal protein isoforms required during syncytial d

215 .226C>T (p.Arg76( *)), in KIZ, which encodes centrosomal protein kizuna.

216 with Bsg25D, the Drosophila homologue of the centrosomal protein Ninein.

217 somal protein 4.1-associated protein (CPAP), centrosomal protein of 152 kDa (CEP152), and centrobin a

218 oteins, Modifier of (mdg4)67.2 (Mod67.2) and Centrosomal Protein of 190kDa (CP190).

219 e/threonine kinase, Aurora A (AurA), and the centrosomal protein of 192 kDa (Cep192)/spindle defectiv

220 in rat brain-11A, Ras-like in rat brain-8A, centrosomal protein of 290 kDa, pericentriolar material

221 ts in human pericentrin (PCNT), encoding the centrosomal protein pericentrin, cause a form of osteody

222 TRIM43 ubiquitinates the centrosomal protein pericentrin, thereby targeting it fo

223 Rotatin is a centrosomal protein possibly involved in centriolar elon

224 Pericentrin is a critical centrosomal protein required for organizing pericentriol

225 has a mutation in KIAA0586, which encodes a centrosomal protein required for the formation of primar

226 yeast two-hybrid screening, we identify the centrosomal protein RSA-2 as a SYS-1 binding partner and

227 identified mutations in a gene encoding the centrosomal protein SDCCAG8 as causing NPHP type 10 in h

228 , microcephaly caused by the loss of the non-centrosomal protein SMC5 is also TP53-dependent but is n

229 3 inflammasome activation is suppressed by a centrosomal protein Spata2.

230 CEP63 is a centrosomal protein that facilitates centriole duplicati

231 er, these results demonstrate that SFI1 is a centrosomal protein that localizes USP9X to the centroso

232 by the protein PCM1, that are implicated in centrosomal protein trafficking.

233 Ninein (Nin) is a centrosomal protein whose gene is mutated in Seckel synd

234 hat mutations in CSPP1, which encodes a core centrosomal protein, are disease causing on the basis of

235 ns, which share similarity with FOP, a human centrosomal protein, are essential for microtubule organ

236 Mutations in CDK5RAP2, which encodes a centrosomal protein, cause autosomal recessive primary m

237 e mutations in CEP41, which encodes a 41-kDa centrosomal protein.

238 influence of DISC1 genotype extends to other centrosomal proteins and DISC1 binding partners remains

239 ) in muscle cells due to the accumulation of centrosomal proteins and microtubule (MT) nucleation act

240 Mutations in several genes encoding centrosomal proteins dramatically decrease the size of t

241 Our results expand the list of centrosomal proteins implicated in human ciliopathies.

242 tubule organization and unexpected roles for centrosomal proteins in epidermal function.

243 aly is caused by mutations in genes encoding centrosomal proteins including WDR62 and KIF2A.

244 melanogaster spermiogenesis, the quantity of centrosomal proteins is dramatically reduced; for exampl

245 from the other events and to determine that centrosomal proteins lead the reorganization hierarchy.

246 Down-regulation of the centrosomal proteins Ninein and adenomatous polyposis co

247 on-induced autophagosome biogenesis, but how centrosomal proteins regulate GABARAP localization is un

248 this paper, we identify a specific subset of centrosomal proteins that are recruited to the cell cort

249 specifically interacts with CP110 and Cep97, centrosomal proteins that play a role in regulating cent

250 These include Lis1 and Ndel1, which are centrosomal proteins that regulate microtubule organizat

251 gesting that Mps1 phosphorylates a subset of centrosomal proteins to drive the assembly of new centri

252 In rat cardiomyocytes, AKAP6 anchors centrosomal proteins to the nuclear envelope through its

253 Redistribution of centrosomal proteins, conditional on differentiation, wa

254 eractions of INPP5E with several ciliary and centrosomal proteins, including a recently identified ci

255 on (BioID) method [13, 14], we found several centrosomal proteins, including Akap450, Pcm1, and Peric

256 The relocalization of centrosomal proteins, including Pericentrin, Pcm1, and g

257 y of kinesin and that Akap450, but not other centrosomal proteins, is required for MT nucleation from

258 We show that, similar to many centrosomal proteins, MeCP2 deficiency causes aberrant s

259 al cells is sufficient to recruit endogenous centrosomal proteins.

260 ic mutations in genes coding for a subset of centrosomal proteins.

261 entriolar satellites, which are comprised of centrosomal proteins.

262 tellite levels were observed for a subset of centrosomal proteins.

263 f centrosomes from cells' ends, we show that centrosomal proximity is predictive of the placement of

264 es Evi5 to centriolar appendages to turn off centrosomal Rab11 activity.

265 Moreover, centriolin depletion displaces the centrosomal Rab11 GAP, Evi5, and increases mother-centri

266 ated Rab11; depletion of Evi5 also increases centrosomal Rab11.

267 stream vesicular transport events leading to centrosomal Rab8 activation and ciliary membrane formati

268 show that TRAPP II subunits colocalize with centrosomal Rabin8 and are required for Rabin8 preciliar

269 reased MT nucleation rate and diminished the centrosomal recruitment of EB1 without affecting MT grow

270 in RNAs or a loss-of-function allele impairs centrosomal recruitment of gamma-tubulin and pericentrin

271 fication in parallel to previously described centrosomal reduction [7].

272 th Rab5a and PKC dynamically interact at the centrosomal region of migrating cells, and PKC-mediated

273 d to MT-associated protein 1B (MAP1B) in the centrosomal region, where it maintained MT acetylation.

274 Our study unravels a novel centrosomal regulatory pathway of inflammasome activatio

275 under all circumstances, and conditional on centrosomal reorganization.

276 ng and phosphorylation of BRCA1 enhanced its centrosomal retention and regulation of centrosome ampli

277 with Aurora A kinase inhibitor, suggesting a centrosomal role for the Aurora A-dependent complex of c

278 r investigating the assembly and function of centrosomal scaffolds in various organisms.

279 erial disorganization, as well as defects in centrosomal separation and mitotic chromosome alignment.

280 l of linker proteins, an event necessary for centrosomal separation and proper formation of the mitot

281 n of loose centrosomal linker and subsequent centrosomal separation.

282 reorganize and move from centrosomal to non-centrosomal sites at the RB-sperm boundary whereas actin

283 MTOC and MTOC function is reassigned to non-centrosomal sites such as the apical membrane in epithel

284 both centrosomal (spindle pole body) and non-centrosomal sites.

285 o recruits the gamma-tubulin complex to both centrosomal (spindle pole body) and non-centrosomal site

286 l differentiation by switching Ninein from a centrosomal splice form in NPCs to a non-centrosomal iso

287 n mammals, Cep250 processing is required for centrosomal splitting and is mediated by Nek phopsphoryl

288 newly synthesized ILK protein colocalized to centrosomal structures and was required for correct cent

289 ial for optimal APC/C activation towards its centrosomal substrate Aurora A.

290 osphoprotein substrate PBIP1, but not to the centrosomal substrate NEDD1.

291 on cycle 20-anaphase promoting complex) as a centrosomal substrate of CaMKIIbeta.

292 wn and unique substrates, including multiple centrosomal substrates for Syk, were identified, support

293 Based on our observations of centrosomal SYS-1 dynamics, we discuss the possibility t

294 We conclude that centrosomal targeting of SYS-1 promotes its degradation

295 The centrosomal targeting sequence of RHAMM was required for

296 necessary and sufficient to mediate HsSAS-6 centrosomal targeting.

297 p115 and gamma-tubulin and functioned in its centrosomal targeting.

298 intact microtubules reorganize and move from centrosomal to non-centrosomal sites at the RB-sperm bou

299 ing PLK4 inhibition depends on levels of the centrosomal ubiquitin ligase TRIM37.

300 data suggest that the mitotic regulation of centrosomal WASH and the Arp2/3 complex controls local a