ライフサイエンスコーパス: ceramide

1 es on longevity (leukemia inhibitory factor, ceramides).

2 ansport reduced the efflux of exogenous C(6)-ceramide.

3 gomyelinase that hydrolyzes sphingomyelin to ceramide.

4 ydrolysis of glucosylceramide to glucose and ceramide.

5 DHA) and accumulated more lipid droplets and ceramide.

6 emphysema is associated with increased lung ceramide.

7 glycolipid glucosylceramide into glucose and ceramide.

8 n attached to a hydrophobic membrane anchor, ceramide.

9 the availability of nutrients and lysosomal ceramide.

10 odulated by competition with nonglycosylated ceramides.

11 he accumulation of IR-related carnitines and ceramides.

12 eloped to comprehensively quantify zebrafish ceramides.

13 ggrin and filaggrin-2, as well as long-chain ceramides.

14 lts in increases in cellular sphingosine and ceramides.

15 ups of diacylglycerols, triacylglycerols and ceramides.

16 es de novo SL production and increases liver ceramides.

17 glycerides, diglycerides, sphingomyelins and ceramides.

18 s was accompanied by accumulation of cardiac ceramides.

19 The sphingolipid ceramide 1-phosphate (C1P) directly binds to and activat

20 active sphingolipids resulting in decreased ceramide-1-phosphate (C1P) content as observed in human

21 In contrast, levels of ceramide-1-phosphate (C1P) dropped in a time-dependent m

22 sphoinositides, diacylglycerolpyrophosphate, ceramide-1-phosphate, and phosphatidic acid belong to a

23 sphingolipids, including phosphatidylserine, ceramide-1-phosphate, glucosylceramide, and sulfatide, v

24 ssociated with HF risk in both cohorts: CER (ceramide) 16:0 (relative risk [RR] per SD in PREDIMED, 1

25 es (PCs), 7 lysophosphatidylethanolamines, 5 ceramides, 3 branched chain amino acids, and 9 neurotran

26 Ceramides, a type of sphingolipid (SL), have been implic

27 Ceramide accumulation determined by liquid chromatograph

28 ighlights the article by Li et al that links ceramide accumulation in podocytes to cellular damage an

29 ed reduced size, early mortality, and severe ceramide accumulation where the amplitude of ceramide ch

30 xpression, which stimulates NOX4 expression, ceramide accumulation, and causes DbCM.

31 n alleviated superoxide formation, prevented ceramide accumulation, and improved cardiac function in

32 Mechanistic studies revealed ceramide actions that promoted lipid uptake and storage

33 Mechanistically, PP2A-Cdc55 ceramide-activated phosphatase was found to act downstre

34 tion, the results revealed that this pool of ceramide acutely regulates cell adhesion and cell migrat

35 Acyl chain length alterations in ceramides also suggested roles for FATP4 in esterifying

36 ge of sphingomyelin to phosphorylcholine and ceramide, an essential step in the formation and release

37 UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-p

38 F-HPA-12, a radio-fluorinated version of the ceramide analog N-(3-hydroxy-1-hydroxymethyl-3-phenylpro

39 -PLs) and palmitoyl ceramide (PCer) or other ceramide analogs in dioleoylphosphatidylcholine (DOPC) b

40 Ceramide analogs like HPA-12 may function as metabolic p

41 fter screening a series of newly synthesized ceramide analogs, here, we have identified compounds wit

42 Processes that can be regulated by ceramide and are important for severity of allergic asth

43 fication of specific and different roles for ceramide and ASM secreted by irradiated endothelial cell

44 ase 2 (nSMase2) produces the bioactive lipid ceramide and has important roles in neurodegeneration, c

45 Here we report that ceramide and its related enzyme acid sphingomyelinase (A

46 an excessive, more than 130-fold increase in ceramide and other sphingolipids.

47 counteract the negative effects of elevated ceramide and promote cell survival, thereby providing ca

48 osphatidylcholine, phosphatidylethanolamine, ceramide and sphingomyelin lipid groups, for example, in

49 in Alzheimer's disease (AD) brain leading to ceramide and sphingosine accumulation and reduced levels

50 responsive to the pro-apoptotic sphingolipid ceramide and that this response is strictly stereospecif

51 Ceramide and the two isoforms of ASM were acutely secret

52 umption with concentrations of 3 circulating ceramides and ceramide ratios.

53 The meC18SO is metabolized to ceramides and complex SLs and is a constituent of human

54 ted accumulation of lipotoxic intermediates (ceramides and diacylglycerols) and reduced reactive oxyg

55 d elevations in myocardial free fatty acids, ceramides and diacylglycerols, consistent with developme

56 loped marked elevations in free fatty acids, ceramides and diacylglycerols.

57 Several of these-ceramides and glucosylceramides-induced differentiation

58 key enzymes that regulate the metabolism of ceramides and glycosphingolipids, which are important me

59 vonic acid enrichment led to increased C24:1-ceramides and improved several metabolic parameters incl

60 esis of cardiotoxic C16- and C24-, and C24:1 ceramides and increased potentially cardioprotective C20

61 It is concluded that ceramides and lyso-PLs associated with each other both i

62 Lower levels of sphingolipids and ceramides and other metabolomic alterations observed in

63 a conserved double bond into the backbone of ceramides and other predominant sphingolipids.

64 tissues revealed an abnormal accumulation of ceramides and other sphingolipids.

65 Prominent sphingolipids include ceramides and sphingosine-1-phosphate that regulate mult

66 centrations that depend on the nature of the ceramides and the co-phospholipids.

67 w opportunities to probe the causal roles of ceramides and their metabolic derivatives in a wide arra

68 , molecular details of the SET-FTY720 or SET-ceramide, and mechanism of FTY720-dependent PP2A activat

69 aluated immune response, Oil Red-O staining, ceramide, and triacylglycerol levels.

70 phospholipids, neutral lipids, cholesterol, ceramides, and free fatty acids.

71 beyond the seedling stage, hyperaccumulated ceramides, and showed altered organellar structures and

72 allergic asthma had higher dihydroceramides, ceramides, and sphingomyelins compared with children wit

73 nallergic asthma had lower dihydroceramides, ceramides, and sphingomyelins than did controls.

74 Free fatty acids, ceramides, and triacylglycerol classes in plasma correla

75 Ceramides are central intermediates of sphingolipid meta

76 types that accumulate, sphingolipids such as ceramides are particularly impactful, as they elicit the

77 inantly acylated to sphingolipids, including ceramides, are selectively reduced in a mouse model of o

78 ve therapy for CLN3 disease and use of serum ceramide as a potential biomarker to track impact of the

79 ions, and the results define plasma membrane ceramide as an acute signaling effector necessary and su

80 This study identifies secreted ASM and ceramide as paracrine factors enhancing intestinal epith

81 scores.CONCLUSIONThis study validates serum ceramides as candidate biomarkers of CVD and suggests th

82 e (ASMase) and generate the second messenger ceramide at plasma membranes, triggering apoptosis in sp

83 ramide upon chemotherapy treatment, and both ceramide at the plasma membrane and nSMase2 were necessa

84 ant enzymes to mimic physiological levels of ceramide at the plasma membrane upon chemotherapy treatm

85 tivate iNKT cells is highly dependent on the ceramide backbone structure.

86 nthetic GM3 and GD3 comprising a d18:1-C24:1 ceramide backbone were able to activate iNKT cells in a

87 ceramide species that are included in other ceramide-based scores.CONCLUSIONThis study validates ser

88 at Asp(147) or Asn(169) of RIPK1 are key for ceramide binding and that Arg(258) or Leu(293) residues

89 on channels VDAC1 and VDAC2 as mitochondrial ceramide binding proteins.

90 FTY720-ceramide binding resulted in chemical shifts of residues

91 mulations reveal that both channels harbor a ceramide binding site on one side of the barrel wall.

92 likely serve as measures of flux through the ceramide biosynthesis pathway rather than the abundant d

93 e (GlcCer), the initial GSL synthesized from ceramide by GCS (GlcCer synthase), is required for embry

94 ceramide synthesis were upregulated and that ceramide (C16, C20, C20:1, and C24) levels had significa

95 pendent variable) to blood concentrations of ceramides (C16:0, C22:0, and C24:0) and ceramide ratios

96 e report on clickable, azobenzene-containing ceramides, caCers, as photoswitchable metabolic substrat

97 re are reports that Chol is able to displace ceramide (Cer) in SM bilayers and abolish the S(o) phase

98 melting of the interior slab, which contains ceramide (Cer) in the posturing chain conformation, a st

99 we quantified sphingolipids including SM and Ceramide (Cer) using Multiple Reaction Monitoring (MRM),

100 d by the saturated fatty acid carried by the ceramide (Cer).

101 Ceramides (Cer) and cerebrosides are important sphingoli

102 win model (h(2) = 0.28-0.59), which included ceramides (Cer) and triglycerides (TG).

103 ceramide accumulation where the amplitude of ceramide change depended on both acyl chain and LCB leng

104 esis identified developmental stage-specific ceramide changes based on long chain base (LCB) length.

105 holipids and increasing long-chain saturated ceramides, changes previously linked to apoptosis.

106 d decreased proportions of these and the two ceramide classes that carry ultralong-chain, amide-linke

107 lize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chem

108 lusion, our findings indicate that the RIPK1-ceramide complex forms large membrane pores we named cer

109 eceptor-interacting Ser/Thr kinase 1 (RIPK1)-ceramide complex transported to the plasma membrane by n

110 olution examination of the SET-FTY720 or SET-ceramide complexes by NMR spectroscopy.

111 cell line demonstrated remarkable overlap in ceramide composition, but also revealed a surprising lac

112 ycerols, and diacylglycerols, although lower ceramide concentrations, in subcutaneous tissue.

113 c lipid metabolism may influence circulating ceramide concentrations.

114 y fatty acids and sphingosines (Cer[NS]) and ceramides containing a-hydroxy fatty acids and sphingosi

115 In the SC ceramide profiles, ceramides containing nonhydroxy fatty acids and 6-hydrox

116 cids and 6-hydroxysphingosines (Cer[NH]) and ceramides containing nonhydroxy fatty acids and phytosph

117 ytosphingosines (Cer[NP]) increased, whereas ceramides containing nonhydroxy fatty acids and sphingos

118 of Ahr knockout mice exhibited both reduced ceramide content and reduced myelin thickness.

119 Ceramides contribute to the lipotoxicity that underlies

120 'Benzoate metabolism', 'ceramides', 'creatine metabolism', 'fatty acid metabolis

121 In particular, the long-chain ceramides d18:1/20:0 and d18:1/24:0 were elevated and li

122 sociation between a genetically instrumented ceramide (d18:1/20:1) and T2D (odds ratio: 1.15 [95% CI

123 n novel and 3 reported sphingolipids, namely ceramides (d18:1/18:1, d18:1/20:0, d18:1/20:1, d18:1/22:

124 o the pathogenesis of atopic dermatitis as a ceramide-deficient disease.

125 cancer cell catabolism of sphingomyelins to ceramide derivatives and 3) altered ceramide metabolism

126 ain groups detected were phenolic compounds, ceramides, diacylglycerols and triacylglycerols.

127 12 may function as metabolic probes to study ceramide disbalance in the brain.

128 Ceramides draw wide attention as tumor suppressor lipids

129 Ceramide elevation drives local bilayer reorganization i

130 Adding exogenous ASM or ceramide enhanced epithelial cell growth arrest and deat

131 nalog drug FTY720, we show that formation of ceramide-enriched membrane pores, referred to here as ce

132 roles in stress-mediated necroptosis, these ceramide-enriched pores also regulate membrane integrity

133 erified omega-hydroxy fatty acid sphingosine ceramides (EOS-CERs) to nonhydroxy fatty acid sphingosin

134 Progress in understanding how ceramides execute their biological roles is hampered by

135 ath, providing a molecular framework for how ceramides exert their anti-neoplastic activity.

136 Ceramides exhibit multiple biological activities that ma

137 Epidermal lipids, such as ceramides, fatty acids (FAs), triglycerides, and cholest

138 tical role in ZIKV replication and show that ceramide flux is a key mediator of ZIKV infection.

139 Sphingomyelinases generate ceramide from sphingomyelin as a second messenger in int

140 ith weak connections to commonly established ceramide functions (eg, cell death).

141 The matrix lipids, especially the ceramide-generated sphingosine 1-phosphate, are the mess

142 only enzyme known to hydrolyze proapoptotic ceramide, generates sphingosine, which is then phosphory

143 upregulation of Smpd3, which encodes for the ceramide-generating enzyme neutral sphingomyelinase 2.

144 ic NLPs bind to glycosyl inositol phosphoryl ceramide (GIPC) sphingolipids that are abundant in the o

145 regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene.

146 the analysis of GSL-derived glycans based on ceramide glycanase digestion, 8-aminopyrene-1,3,6-trisul

147 Ceramides have been implicated in the pathogenesis of ty

148 tamate that mediates direct contact with the ceramide head group.

149 idase (Ac) has been shown to be critical for ceramide hydrolysis and regulation of lysosome function

150 crucial role in the metabolism of lysosomal ceramides, important members of the sphingolipid family,

151 ed by performing behavioral tests, measuring ceramide in brains and serum, and assessing impact on lo

152 sought to investigate the functional role of ceramide in mouse models of allergic airway disease that

153 y, lipidomics analyses showed that increased ceramides in PKM2-activated T-cell EVs were mainly respo

154 Thus, PKM2-mediated EV ceramides in T cells may be an important cargo for T-cel

155 prising lack of most sphingadiene-containing ceramides in the zebrafish.

156 we measured sphingolipids (including S1P and ceramides) in AML and control cells.

157 est vital roles of sphingolipids, especially ceramides, in the pathogenesis of type 2 diabetes (T2D)

158 ts for each gene, accumulated high levels of ceramide, indicative of unregulated sphingolipid biosynt

159 ent of neurons with medium supplemented with ceramides, induced a time-dependent increase of the tran

160 uman colon cancer cells largely resistant to ceramide-induced apoptosis.

161 Ceramide-induced endothelial cell apoptosis boosts intes

162 Notably, the drug rescued C2 ceramide-induced ER stress-mediated apoptosis and ER str

163 Remarkably, ceramide-induced RIP of cAMP response element-binding pr

164 In MVBs, acid ceramidase (aCDase) converts ceramide into sphingosine and increases the formation of

165 Acid ceramidase (AC) hydrolyzes ceramides into sphingoid bases and fatty acids.

166 Ceramide inverts the orientation of newly synthesized TM

167 hingomyelinase (SMPD1) and the generation of ceramide is a critical regulator of apoptosis in respons

168 murine models.Measurements and Main Results: Ceramide is increased in cystic fibrosis airway epitheli

169 This is the first time a specific pool of ceramide is interrogated for acute signaling functions,

170 The metabolism of ceramides is deregulated in the brain of Alzheimer's dis

171 t manner although mRNA and protein levels of ceramide kinase (CERK) remained stable.

172 nal ceramide metabolism, specifically in the ceramide kinase like (CERKL) gene.

173 ingolipid analog drug fingolimod (FTY720) or ceramide leads to the reactivation of tumor suppressor P

174 Our data suggest that elevation of ceramide level after allergen challenge contributes to t

175 t had no significant effects on elevation of ceramide level or apoptosis, indicating that the increas

176 IP re-expression in leukemia cells increased ceramide levels 2-fold, inactivated the key signaling pr

177 Brain and serum ceramide levels as well as apoptosis rates were lower in

178 es to ZIKV replication sites, and increasing ceramide levels by multiple pathways sensitizes cells to

179 tosis, indicating that the increases in lung ceramide levels in allergen-challenged mice are not medi

180 rogliosis, and diminution in brain and serum ceramide levels in Cln3 (Deltaex7/8) knock-in mice.

181 The increased ceramide levels in mammalian heart tissues during acute

182 Thus ceramide levels in the CSF of patients with progressive

183 nown about the mechanisms by which increased ceramide levels in the lung contribute to allergic respo

184 cell processes like apoptosis, cell membrane ceramide levels increase markedly because of the activat

185 rity of allergic asthma were correlated with ceramide levels measured by mass spectrometry.

186 Prevention of increases in lung ceramide levels mitigated allergen-induced apoptosis, re

187 g attempts to develop therapeutics to reduce ceramide levels to combat metabolic disease.

188 ) mice the allergen-induced increase in lung ceramide levels was significantly reduced, whereas total

189 wn-regulation in AML reduces SK activity and ceramide levels, an effect that ultimately inhibits apop

190 ulation caused SMPD3 upregulation, increased ceramide levels, and inhibited the tumorigenic activity

191 ORMDL3 regulates systemic ceramide levels, but genetically interfering with Ormdl3

192 Ceramide levels, in particular C16 ceramide, were rapidl

193 ost-MI after AC modRNA delivery to decreased ceramide levels, lower cell death rates, and changes in

194 LCKD decreased C22:1-ceramide levels, which are reported to be high in pancre

195 unoreactivity inversely related to SMPD3 and ceramide levels.

196 almitoyl transferase in response to elevated ceramide levels.

197 o-PC, similarly to PCer, suggesting that the ceramide/lyso-PL interaction was not sensitive to struct

198 Ceramides may inhibit the expression of PEMT by increase

199 ham Heart Study's Offspring Cohort who had 3 ceramides measured (n = 1561, mean age 66 y, 59% women).

200 upport a role of VDAC2 as direct effector of ceramide-mediated cell death, providing a molecular fram

201 Use of enteroid models revealed ASM and ceramide-mediated deleterious mode-of-action: when ceram

202 Here, we further examined the role of ceramide-mediated signaling in hepatic dyslipidemia caus

203 However, how the ceramide metabolism changes over time in AD, in vivo, re

204 Our data gives additional proof that ceramide metabolism is different in FAD mice compared to

205 elins to ceramide derivatives and 3) altered ceramide metabolism that results in increased glycosphin

206 We investigated the effect of altering ceramide metabolism through a loss (chemical inhibitors)

207 herin, its abundance in circulation, role in ceramide metabolism, and homology to C1q suggest an over

208 n patients with mutations that alter retinal ceramide metabolism, specifically in the ceramide kinase

209 rough regulation of ceramide synthesizing or ceramide metabolizing enzymes and dramatically suppress

210 Ceramide might be the trigger of formation of Creola bod

211 interactions between the oligosaccharide and ceramide moieties of GT1b and the juxtamembrane and tran

212 t sensitive to structural alterations in the ceramide molecule.

213 lls with a Golgi staining reagent, NBD C(6) -ceramide, NIR imaging in the Golgi apparatus has been de

214 S-CERs) to nonhydroxy fatty acid sphingosine ceramides (NS-CERs) in the skin.

215 bilization in the presence of Chol or oleoyl-ceramide (OCer).

216 ulate sphingomylinases and increase cellular ceramide, often linked to the induction to cell death.

217 associated with concentrations of the C24:0 ceramide only in individuals with prediabetes or diabete

218 without significant changes in inflammation, ceramide or diglyceride contents, endoplasmic reticulum

219 Here, we report that ceramide or related sphingolipids might invert the topol

220 er total diacylglycerol (P = 0.123) or total ceramides (P = 0.150).

221 bolism and increased intracellular levels of ceramide, paralleled by a nonredundant upregulation of S

222 r lysophospholipids (lyso-PLs) and palmitoyl ceramide (PCer) or other ceramide analogs in dioleoylpho

223 palmitoyl sphingomyelin (PSM) and palmitoyl ceramide (PCer).

224 gesting a functional pathway that integrates ceramide, PEMT, and glycerolipid biosynthetic pathways.

225 Ceramide perturbations may cause adaptive alterations in

226 us to identify an elevation in the levels of ceramide phosphates and sphingosine phosphates in tumor

227 agnostic potential and clinical relevance of ceramide phosphates in breast cancer.

228 tabase comprises sphingomyelin, cerebroside, ceramide, phosphatidylethanolamine, phosphatidylcholine,

229 Bacteroides-derived sphingolipids including ceramide phosphoinositol and deoxy-sphingolipids.

230 consumption and concentrations of the C24:0 ceramide (Pinteraction = 0.014).

231 c dexamethasone treatment induces an ANGPTL4-ceramide-PKCzeta axis that activates hepatic de novo lip

232 in intestinal inflammation and altered host ceramide pools in mice.

233 ed potentially cardioprotective C20- and C22-ceramides post-TAC.

234 Using a photoactivatable ceramide probe, we here identify the voltage-dependent a

235 shes photolabeling of both channels with the ceramide probe.

236 inase-2 (nSMase2: SMPD3) is a key enzyme for ceramide production involved in inflammation, we investi

237 ptosis, cell-cycle arrest, and intracellular ceramide production through regulation of ceramide synth

238 on and stretch, and its inhibition prevented ceramide production, LC3B-II formation, LC3B/first apopt

239 dings on the regulatory pathways controlling ceramide production, the molecular mechanisms linking th

240 e required for dexamethasone-induced hepatic ceramide production.

241 the penetrated pCer contributes to shift the ceramide profile from an atopic dermatitis to a healthy

242 pathophysiological linkages between altered ceramide profiles in the stratum corneum (SC) of patient

243 In the SC ceramide profiles, ceramides containing nonhydroxy fatty

244 Ventilation-induced ceramides promote autophagy-mediated cell death, and ide

245 d with concentrations of the C16:0 and C22:0 ceramides (Ptrend < 0.05).

246 s of ceramides (C16:0, C22:0, and C24:0) and ceramide ratios (C22:0/C16:0 and C24:0/C16:0).

247 oncentrations of 3 circulating ceramides and ceramide ratios.

248 Additionally, the sphingolipid ceramide redistributes to ZIKV replication sites, and in

249 de-mediated deleterious mode-of-action: when ceramide reduced the number of intestinal crypt-forming

250 combinant human acid ceramidase, to decrease ceramide, reduced both inflammatory mediator production

251 We previously reported that ceramide regulates a transmembrane protein called TM4SF2

252 is strictly stereospecific, indicating that ceramide regulates the ORMDL-SPT complex via a specific

253 r mean concentrations of the C16:0 and C22:0 ceramides, respectively.

254 In DOPC bilayers, PCer forms a ceramide-rich phase at concentrations above 10 mol%.

255 PCer is known to segregate laterally into a ceramide-rich phase at concentrations that depend on the

256 ion drives local bilayer reorganization into ceramide-rich platforms, macrodomains (0.5-5-um diameter

257 t for socioeconomic and lifestyle factors, a ceramide score (RR Q4 versus Q1 = 2.40; 95% CI: 1.24, 4.

258 re used to demonstrate the role of lysosomal ceramide signaling pathway in AMC.

259 ory lipidomic study that identified specific ceramide species as differentially abundant in the CSF o

260 SKI-II increased ceramide species but decreased sphingomyelin and sphingo

261 pathway rather than the abundant deleterious ceramide species that are included in other ceramide-bas

262 Moreover, specific ceramide species were altered in bronchoalveolar lavage

263 dose of radiation, long and very-long-chain ceramide species, and the expression levels of SMPDL3b w

264 ility that higher concentrations of distinct ceramide species, previously associated with adverse met

265 1 and WaGa cells myriocin decreased cellular ceramide, sphingomyelin, and sphingosine-1-phosphate con

266 cant accumulation of sphingolipids including ceramides, sphingosine and sphingosine 1-phosphate (S1P)

267 its glycosphingolipid receptor, GM1, and the ceramide structure of GM1 is likely not a determinant of

268 We show that epidermal loss of ceramide synthase 4 first disturbs epidermal lipid metab

269 onged barrier dysfunction induced by loss of ceramide synthase 4 induced a barrier repair response th

270 rrier and functionally identify differential ceramide synthase 4 protein expression as one key differ

271 ssociated with CGG repeats, such as Schlank (ceramide synthase), Sk2 (sphingosine kinase) and Ras (IM

272 ionally, the impact of galactosylceramide on ceramide synthesis enzymes is documented.

273 DEGS1, which catalyzes the last step in the ceramide synthesis pathway.

274 found that several genes involved in de novo ceramide synthesis were upregulated and that ceramide (C

275 or of the rate-controlling enzyme of de novo ceramide synthesis, serine palmitoyltransferase long-cha

276 bserved with the direct inhibition of SPT or ceramide synthesis.

277 ar ceramide production through regulation of ceramide synthesizing or ceramide metabolizing enzymes a

278 chondrial ROS induce production of lysosomal ceramide that ultimately activates the cytosolic protein

279 of which could be recapitulated by (dihydro)ceramides that lacked the critical double bond.

280 ma by modulating the levels of intracellular ceramide, thus providing novel opportunities for melanom

281 PCer with lyso-PLs was driven by the need of ceramide to obtain a large-headgroup co-lipid, and satur

282 d intracellular and extracellular functions (ceramide trafficker and protein kinase).

283 e to the maintenance of ERTGoCS, such as the ceramide transfer protein CERT and several members of th

284 response to ventilation and stretch, and C16 ceramide treatment of FRLE cells induced autophagy and a

285 nsible for the generation of plasma membrane ceramide upon chemotherapy treatment, and both ceramide

286 pathophysiological linkage by microanalyzing ceramides using normal phase liquid chromatography-elect

287 Interestingly, serum ceramide was not enhanced in irradiated ASMKO mice, whic

288 possible functions of this specific pool of ceramide, we used recombinant enzymes to mimic physiolog

289 rmore, other bioactive sphingolipids such as ceramide were also down-regulated in primary AML cells.

290 y complexes containing palmitoyl lyso-PC and ceramide were prepared, and these had a bilayer structur

291 Because ASM/ceramide were secreted by primary endothelial cells, the

292 Whole-blood dihydroceramides and ceramides were decreased in subjects with the 17q21 asth

293 Ceramide levels, in particular C16 ceramide, were rapidly elevated in response to ventilati

294 um, levels of total sphingolipids, including ceramides, were increased in Ormdl3(-/-) mice, whereas t

295 icin and vorinostat still increased cellular ceramide, which was located predominantly at the plasma

296 essed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG m

297 f phosphatidylethanolamines and glycosylated ceramides, which were poorly detected in MALDI-MSI.

298 Sphingosine, a metabolite of ceramide with antimicrobial properties, is not upregulat

299 ted significantly lower levels of glomerular ceramide with decreased podocyte injury compared with As

300 ACSL1 trafficked LCFA into ceramides without normalizing the reduced triglyceride s