ライフサイエンスコーパス: ceramide synthase

1 onisin B1, an in vitro inhibitor of (dihydro)ceramide synthase.

2 e used fumonisin B1, a specific inhibitor of ceramide synthase.

3 pathway by coordinate activation of SPT and ceramide synthase.

4 onisin B1, an inhibitor of the CoA-dependent ceramide synthase.

5 ovo synthesis coordinated through the enzyme ceramide synthase.

6 ently evolved into a non-functional "pseudo" ceramide synthase.

7 es dampened the activating effect of ORMs on ceramide synthase.

8 enerates the C-terminal peptide-epitope of a ceramide synthase.

9 an activator of class II (or LOH1 and LOH3) ceramide synthases.

10 Ceramide synthase 1 (CerS1) catalyzes the synthesis of C

11 S aureus abundance and ceramide synthase 1 (CERS1) expression positively correl

12 ration of C18-ceramide via the expression of ceramide synthase 1 (CerS1), and not C16-ceramide by Cer

13 Mechanistically, LCL768 induced ceramide synthase 1 (CerS1)-mediated endogenous C18-cera

14 Inositol-phosphoryl ceramide synthase 1 (Ipc1) is a fungus-specific enzyme,

15 the sphingolipid enzyme inositol-phosphoryl ceramide synthase 1 (Ipc1) regulates melanin production

16 onymous mutation in CERS1, the gene encoding ceramide synthase 1, in 4 siblings affected by a progres

17 novo-generated C(18)- and C(16)-ceramides by ceramide synthases 1 and 6 (CerS1 and CerS6) play opposi

18 ement binding protein pathway as it requires ceramide synthase 2 (CerS2) activity, epidermal growth f

19 high expression of their synthetic enzymes, ceramide synthase 2 (CerS2) and CerS5, respectively.

20 ACBP increases the activity of ceramide synthase 2 (CerS2) by more than 2-fold and CerS

21 Analysis of serum from Ceramide Synthase 2 (CerS2) null mice using the Q-RAI DI

22 We recently generated a ceramide synthase 2 (CerS2) null mouse that cannot synth

23 chain length in insulin signaling by using a ceramide synthase 2 (CerS2) null mouse, which is unable

24 chain (C22-C24) ceramides are synthesized by ceramide synthase 2 (CerS2).

25 Accordingly, genetic deletion of ceramide synthase 2 (encoded by Cers2), the enzyme respo

26 , serine palmitoyltransferase 1 [SPTLC1] and ceramide synthase 2 [CERS2]) of de novo ceramide biosynt

27 Ceramide synthesis through the ceramide synthase 2 de novo pathway is regulated by UPR

28 ed that FTY720 is a competitive inhibitor of ceramide synthase 2 toward dihydrosphingosine with an ap

29 SNP and eQTL for CERS2 encoding the protein ceramide synthase 2.

30 chanistically, Bcl2L13 binds to proapoptotic ceramide synthases 2 (CerS2) and 6 (CerS6) via a unique

31 ased levels of maternal transcripts encoding ceramide synthase 2b (Cers2b), and loss of Cers2b in sph

32 these ultra long-chain ceramides (ELOVLs and ceramide synthase 3).

33 e, we identify a stem cell-specific role for ceramide synthase 4 (CerS4) in orchestrating fate decisi

34 Our study reveals that ceramide synthase 4 displays an antiviral activity again

35 We show that epidermal loss of ceramide synthase 4 first disturbs epidermal lipid metab

36 onged barrier dysfunction induced by loss of ceramide synthase 4 induced a barrier repair response th

37 rrier and functionally identify differential ceramide synthase 4 protein expression as one key differ

38 Host ceramide synthase 4 regulates the level of ceramides tha

39 ver, influenza virus triggers degradation of ceramide synthase 4, which could favor virus replication

40 , 1-deoxysphinganine selectively upregulated ceramide synthase 5 expression and was converted to 1-de

41 and demonstrated a requirement for (dihydro)ceramide synthase 5 in cardiomyocyte autophagy and myris

42 phingosine kinase-2, neutral ceramidase, and ceramide synthase-5.

43 specimens and cell lines and determined that ceramide synthase 6 (CERS6) is markedly overexpressed co

44 16-ceramide and a transient up-regulation of ceramide synthase 6 (CerS6) mRNA and protein.

45 Ceramide synthase 6 (CerS6) preferentially generates C14

46 Our previous study suggested that ceramide synthase 6 (CerS6), an enzyme in sphingolipid b

47 istant SW620 cells expressed lower levels of ceramide synthase 6 (CerS6, also known as longevity assu

48 use line harboring an enzymatically inactive ceramide synthase 6 (CerS6KO) gene and lacz reporter cDN

49 k of CD95 activation and lower expression of ceramide synthase 6 (LASS6).

50 A novel role for ceramide synthase 6 in mouse and human alcoholic steatos

51 hagy that was dependent on the expression of ceramide synthase 6.

52 umonisin B1, a specific natural inhibitor of ceramide synthase, abrogated both ceramide production an

53 fferentially regulates functionally distinct ceramide synthase activities as part of a broader sphing

54 sulted in a rapid increase (within 5 min) in ceramide synthase activity (as measured by incorporation

55 tamin C, attributable, in part, to increased ceramide synthase activity (over 2-fold, p = 0.01); both

56 es, in contrast, displayed increased class I ceramide synthase activity but reduced class II ceramide

57 led as excellent probes for the profiling of ceramide synthase activity in intact cells.

58 accumulation of ceramide via stimulation of ceramide synthase activity in mitochondria, and that JNK

59 This ceramide synthase activity is CoA-independent and is res

60 TNFalpha-induced cell death, suggesting that ceramide synthase activity is crucial for the progressio

61 The (dihydro)ceramide synthase activity of the mutants was tested usi

62 However, TPA induced an increase in ceramide synthase activity that persisted for at least 1

63 The latter imparts (dihydro)ceramide synthase activity to yeast cells.

64 increase (215% above control; 10 microM) in ceramide synthase activity.

65 amide synthase activity but reduced class II ceramide synthase activity.

66 oyl-CoA (or palmitoyl-acyl carrier protein), ceramide synthase adds the second acyl chain, and a redu

67 d (addition of fumonisin B1, an inhibitor of ceramide synthase) also reduced [3H]PDBu binding; theref

68 de generation by activation of mitochondrial ceramide synthase and de novo synthesis of ceramide.

69 ly, fumonisin B1, which selectively inhibits ceramide synthase and decreases de novo formation of cer

70 found that TLCD1 structurally resembles the ceramide synthase and fatty acid elongase families of co

71 m cells was obliterated upon inactivation of ceramide synthase and restored upon microinjection of lo

72 de was dependent upon the activities of both ceramide synthase and serine palmitoyltransferase.

73 nerate ceramide via activation of the enzyme ceramide synthase and signal apoptosis.

74 first time the ability of FTY720 to inhibit ceramide synthases and modulate the intracellular balanc

75 IR triggers SIRT3-dependent deacetylation of ceramide synthases and the elevation of ceramide, which

76 ve useful to study the role of the different ceramide synthases and the resulting N-acyl (dihydro)cer

77 Fumonisin B(1), an inhibitor of ceramide synthase, and glutathione, an inhibitor of neut

78 Both fumonisin B1, an inhibitor of ceramide synthase, and ISP-1, myriocin an inhibitor of s

79 nd that de novo ceramide synthesis involving ceramide synthase appears to be responsible for heat-ind

80 e found that serine palmitoyltransferase and ceramide synthase are localized to the cytoplasm, wherea

81 Finally, enzymatic assays identified ceramide synthase as the mechanism by which BAK regulate

82 crom), a specific inhibitor of CoA-dependent ceramide synthase, blocked 80% of the ceramide generated

83 inhibited by fumonisin B(1), an inhibitor of ceramide synthase, but not by ISP-1, an inhibitor of ser

84 ely blocked by fumonisin B1, an inhibitor of ceramide synthase, but only partially reduced by myrioci

85 at of fumonisin B1, a classical inhibitor of ceramide synthases, but differed in the efficiency to in

86 First, inhibition of glucosyl ceramide synthase by a new specific inhibitor of d-l-thr

87 oid bases are also produced by inhibition of ceramide synthase by fumonisins, mycotoxins produced by

88 Fumonicin B1, an inhibitor of ceramide synthase, can only prevent mitochondrial cerami

89 Ceramide synthases catalyze an N-acyltransferase reactio

90 l ceramide biosynthesis via deacetylation of ceramide synthase (CerS) 1, 2, and 6.

91 ells showed decreases in ceramide levels and ceramide synthase (CerS) 2 expression.

92 sed by a transiently increased expression of ceramide synthase (CerS) 6 in monocytes/macrophages and

93 SPTLC3 catalytic subunit, as well as reduced ceramide synthase (CerS) activity related to reduced exp

94 In human cells, SL levels are regulated by ceramide synthase (CerS) enzymes that produce ceramides,

95 The current study demonstrates that ceramide synthase (CerS) expression in specific tissues

96 etabolism and are largely synthesized by six ceramide synthase (CerS) isoforms (CerS1-6), each with a

97 n of ceramides is determined by six (dihydro)ceramide synthase (CerS) isoforms.

98 dent endoplasmic reticulum membrane protein, ceramide synthase (CerS), contains a higher abundance of

99 ted cell death, suggesting the presence of a ceramide synthase (CerS)-dependent, sphingosine-derived

100 he sole source for SMs, we hypothesized that ceramide synthase (CerS)-derived ceramides regulate ABCB

101 ne by a multicomponent enzyme complex termed ceramide synthase (CerS).

102 expression of the C(16:0) ceramide-producing ceramide synthase (CerS)6 in cultured hypothalamic neuro

103 The subtype ceramide synthase (CerS)6 was specifically up-regulated

104 in B(1) (FB(1)) is a mycotoxin that inhibits ceramide synthases (CerS) and causes kidney and liver to

105 Ceramides are synthesized by a family of six ceramide synthases (CerS) in mammals, which produce cera

106 sphingolipid metabolism, is generated by six ceramide synthases (CerS) that differ in substrate speci

107 sphingolipids, is synthesized by a family of ceramide synthases (CerS) that each use acyl-CoAs of def

108 ceramides are synthesized by a family of six ceramide synthases (CerS), transmembrane proteins locate

109 s determined by the specificity of different ceramide synthases (CerS).

110 s inhibited by fumonisin B1, an inhibitor of ceramide synthases (CerS).

111 Ceramide synthases (CerS1-CerS6), which catalyze the N-a

112 chondrial membrane attenuated trafficking of ceramide synthase CerS6 to mitochondria in aging AD T ce

113 Ceramide synthases (CerSs) are responsible for producing

114 ty synthesized via the enzymatic activity of ceramide synthases (CerSs), six of which have been ident

115 olecule generated via the action of (dihydro)ceramide synthases (CerSs), which use two substrates, na

116 ch pinpointed both catalytic subunits of the ceramide synthase complex.

117 ynthesis by post-translational activation of ceramide synthase (CS) and apoptosis.

118 tosis, mediated via activation of the enzyme ceramide synthase (CS) and de novo synthesis of the sphi

119 alternate cell death mechanism, mediated via ceramide synthase (CS)-stimulated de novo synthesis of t

120 thase rather than sphingomyelinases and that ceramide synthase-dependent ceramide generation plays a

121 role of CerS6 in mitochondria revealed that ceramide synthase down-regulation is associated with dra

122 istent with these findings, mutations in the ceramide-synthase-encoding genes barA and lagA also caus

123 or-activated receptor-alpha phosphorylation, ceramide synthase expression and ceramide concentrations

124 Functional analysis of the ceramide synthase family in Arabidopsis thaliana demonst

125 synthesis by treatment with the inhibitor of ceramide synthase, fumonisin B(1).

126 The specific inhibitor of ceramide synthase, fumonisin B1 (50 microM), was able to

127 as abrogated by the competitive inhibitor of ceramide synthase, fumonisin B1.

128 We report that inactivation of glucosyl ceramide synthase (GCS), either by RNAi or with the smal

129 dria, thereby implicating CerS6 as a primary ceramide synthase generating C(16:0)-ceramide.

130 als, and mutants lacking one of these, HYL-1/ceramide synthase, have defects in synaptic transmission

131 could be attributed to increased activity of ceramide synthase (i.e., 1.7-fold increase 8 h after ult

132 Knockdown of individual ceramide synthases identified CerS6 and its product C16-

133 However, the role of ceramide synthase in enhanced ceramide generation in res

134 ll mice, and SIRT3 directly deacetylates the ceramide synthases in a NAD(+)-dependent manner that inc

135 Inhibition of ceramide synthases in hepatocytes increased cellular S1P

136 sis demonstrated that these modifications of ceramide synthase increased its specific activity and st

137 showed that SIRT3-mediated deacetylation of ceramide synthases increased enzyme activity and ceramid

138 was independent of de novo synthesis, since ceramide synthase inhibition (with fumonisin B1) had no

139 or cells with FAS siRNA in the presence of a ceramide synthase inhibitor abrogated the up-regulation

140 The ceramide synthase inhibitor fumonisin B1 did not affect

141 icles from virus producer cells treated with ceramide synthase inhibitor fumonisin B1 or glucosylcera

142 PP2A inhibitors fostriecin and okadaic acid, ceramide synthase inhibitor fumonisin B1, and ROS scaven

143 eath in 30% of cells) in the presence of the ceramide synthase inhibitor fumonisin B1, which inhibite

144 wever, addition of fumonisin B1, a selective ceramide synthase inhibitor, attenuated TNF-alpha/CHX-in

145 of this hypothesis, we find that the potent ceramide synthase inhibitor, australifungin, completely

146 The inclusion of fumonisin B1, a ceramide synthase inhibitor, blocked PSC 833-induced cer

147 s was partially decreased by Fumonisin B1, a ceramide synthase inhibitor.

148 the N-acyl-sphinganine dehydrogenase (e.g., ceramide synthase) inhibitor significantly attenuated ca

149 ate for both serine palmitoyltransferase and ceramide synthase, into C16-ceramide, whereas SphK1 decr

150 ate for both serine palmitoyltransferase and ceramide synthase, into C16-ceramide.

151 tion of dihydrosphingosine or sphingosine by ceramide synthase is inhibited by the fungal toxin fumon

152 with wild-type plants, indicating that LOH1 ceramide synthase is most strongly inhibited by FB1.

153 novo ceramide generation through the enzyme ceramide synthase is required.

154 ed CerS6 and its product C16-ceramide as the ceramide synthase isoform essential for the regulation o

155 indicated that, as in humans and plants, the ceramide synthase isoforms found in Toxoplasma and other

156 asia-mutated (ATM) kinase normally represses ceramide synthase, its derepression in Atm(-/-) mice inc

157 generate ceramide precursors, activation of ceramide synthase itself, or both.

158 s a fully functional orthologue of the yeast ceramide synthase (Lag1p) capable of catalyzing the conv

159 to the actions of acid sphingomyelinase and ceramide synthase LASS 5, demonstrating the action of th

160 nses, are generated by a family of (dihydro) ceramide synthases (Lass1-6/CerS1-6).

161 ecognized crypt stem cell target, activating ceramide synthase-mediated apoptosis to initiate intesti

162 ssor p53)-mediated accumulation of EGL-1 and ceramide synthase-mediated generation of ceramide throug

163 h phenocopied the Atm(-/-) mouse, reordering ceramide synthase-mediated stem cell death to become the

164 pted IPT1, the mannosyl-diinositolphosphoryl-ceramide synthase of S. cerevisiae.

165 Decreasing ceramide levels by inhibiting ceramide synthase or neutral sphingomyelinase 2 leads to

166 induced via IsoGb4, which indicated that the ceramide synthase pathway is likely to be involved in ap

167 Fumonisin B1, an inhibitor of ceramide synthase, prevented S1P-induced elevation of al

168 rst evidence that H(2)O(2) is a regulator of ceramide synthase rather than sphingomyelinases and that

169 In cells, pharmacologic inhibition of ceramide synthase reduced lipid accumulation by reducing

170 ulator of bioactive sphingolipid metabolism, ceramide synthase, required for the production of functi

171 y artery endothelial cells, FTY720 inhibited ceramide synthases, resulting in decreased cellular leve

172 monstrate that overexpression of Arabidopsis ceramide synthases results in strongly divergent physiol

173 se (SPT), or fumonisin B(1), an inhibitor of ceramide synthase, retarded ceramide formation in respon

174 RNAi knockdown of the upstream ceramide synthase schlank in glia of ifc mutants rescues

175 ssociated with CGG repeats, such as Schlank (ceramide synthase), Sk2 (sphingosine kinase) and Ras (IM

176 f SPT as well as fumonisin inhibition of the ceramide synthases, suggesting that increased expression

177 localization and analyses of the Toxoplasma ceramide synthases TgCerS1 and TgCerS2.

178 the results demonstrated that this "pseudo" ceramide synthase, TgCerS2, has a considerably greater r

179 eover, A. nidulans possesses a second likely ceramide synthase that is essential and also regulates h

180 how that BarA, a putative acyl-CoA-dependent ceramide synthase that is unique to filamentous fungi me

181 ound to have reduced activity of the class I ceramide synthase that uses C16 fatty acid acyl-coenzyme

182 ubstrates but increased activity of class II ceramide synthases that use very-long-chain fatty acyl-c

183 H1; At3g25540)- and LOH3 (At1g19260)-encoded ceramide synthases use very-long-chain fatty acyl-CoA an

184 LCB substrates, and LOH2 (At3g19260)-encoded ceramide synthase uses palmitoyl-CoA and dihydroxy LCB s

185 ndria because of activation of mitochondrial ceramide synthase via post-translational mechanisms.

186 fam57ba, encoding a ceramide synthase, was identified as interacting with th

187 nce of acylation of increased sphingosine by ceramide synthase, we used fumonisin B1, a specific inhi

188 equired for apoptosis, because inhibition of ceramide synthase with fumonisin B1 decreased apoptosis

189 Inhibition of ceramide synthase with fumonisin B1 prevented p53 reacti

190 A family of six ceramide synthases with distinct but overlapping substra

191 psis thaliana) contains three genes encoding ceramide synthases with distinct substrate specificities