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1 ccurately describe the function of mammalian Cerberus.
2 4 (caAlk4), induced both cardiac markers and Cerberus.
3 nal repressor Hex while Dkk-1 did not induce Cerberus.
4 ls (Vg1, Xnr1-2) can induce ectopic XHex and cerberus.
5 al injection of XHex mRNA can induce ectopic cerberus.
6 sc, Xeomes, Xapod, Xchordin, Mix1, Xlim1 and Cerberus.
7                          The NODAL inhibitor cerberus 1 acts downstream of WNT to refine the endoderm
8 /bone morphogenetic protein (BMP) antagonist Cerberus-1 (Cer1) in embryonic stem cell cultures orches
9                                     However, Cerberus, a secreted protein that also induces an ectopi
10                                 In addition, Cerberus alone blocks signaling by Activin- and Nodal-li
11                                              Cerberus alone was found sufficient to initiate cardioge
12                                              CERBERUS (also known as LIN) and VAPYRIN (VPY) are essen
13 dorsoanterior endoderm, which expressed both cerberus and a subset of the genes expressed by the prec
14  effect of morpholino-medicated knockdown of Cerberus and Hex, which is required for Dkk1-induced car
15 Nodal extracellularly, the Nodal antagonists Cerberus and Lefty are permissive for ADMP activity.
16 expression of the anterior endodermal marker Cerberus and other mesendodermal genes downstream of Wnt
17 s inhibits expression of the anterior marker Cerberus and results in anterior truncations.
18     Members of the protein family comprising Cerberus and the putative tumour suppressor Dan have not
19 amily that includes the head-inducing factor Cerberus and the tumor suppressor DAN.
20 e expression of the organizer genes chordin, cerberus and Xnr3, but they were not necessary for the e
21 nteriorly expressed genes including Chordin, Cerberus, and Blimp1.
22 rganizer factors, including goosecoid, Xnot, Cerberus, and chordin, are severely reduced.
23  provide support for the model that Gremlin, Cerberus, and DAN block BMP signaling by binding BMPs, p
24          Therefore, we propose that Gremlin, Cerberus, and DAN control diverse processes in growth an
25 es downstream of the BMP antagonists noggin, cerberus, and gremlin since ectodermal explants expressi
26 igands are limited, and include follistatin, Cerberus, and Lefty.
27 ion of mesodermal marker genes such as Xbra, Cerberus, and Otx2, which are subsequently down-regulate
28 ll as the anterior endodermal genes Xhex and cerberus, and the organizer specific gene, Xlim1, are do
29                         In Xenopus, XHex and cerberus are early marker genes of the anterior endomeso
30   Surprisingly, although no known targets of Cerberus are expressed asymmetrically on the right side
31                               Using XHex and cerberus as markers we have examined the signals underly
32       Thus, our findings expand the roles of Cerberus as TGF-beta family signaling inhibitor, provide
33 porter gene assays, we discovered that human Cerberus bound and inhibited the TGF-beta family ligands
34 resses mCer1 which, like its Xenopus homolog cerberus, can induce markers of cardiac specification an
35                                        Chick Cerberus (cCer) was found to be expressed in the left he
36 tion of the organizer genes Goosecoid (Gsc), Cerberus (Cer), and Chordin (Chd).
37 odal inhibitors Lefty2 (Lefty) and truncated Cerberus (Cerb-S) and by pharmacological interference us
38                                              CERBERUS colocalized with the trans-Golgi network/early
39 N-terminal region, and support the idea that Cerberus could have regulatory activities beyond direct
40 eir activity is modulated by a member of the Cerberus/Dan family of BMP antagonists, Protein Related
41 characterization of 51-B6, a novel member of Cerberus/Dan family of secreted BMP inhibitors, which we
42  secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (S
43 ated by Caronte (Car), a novel member of the Cerberus/Dan gene family, which induces targets by antag
44             The carboxy-terminal fragment of Cerberus, designated Cer-S, provides a specific secreted
45              Since the specific knockdown of Cerberus did not abrogate heart induction by the Wnt ant
46                            The expression of cerberus during gastrulation is activated by earlier nod
47                                     The gene cerberus encodes a secreted protein that is expressed in
48                Microsurgical ablation of the cerberus-expressing endoderm decreased the incidence of
49                              In Xenopus, the cerberus-expressing endoderm is required for heart, but
50 entral misexpression of XHex induced ectopic cerberus expression and conferred anterior signalling pr
51 ssion of the Wnt target gene snail2 restores cerberus expression and rescues the eye defects caused b
52 ordin are important for maintaining XHex and cerberus expression.
53 alling components blocks endogenous XHex and cerberus expression.
54 C cofactors and antagonists of the Lefty and Cerberus families of proteins, allowing precise control
55                       It is thought that the Cerberus Fossae fissures on Mars were the source of both
56                          Our work shows that Cerberus Fossae provided the waters that carved Marte Va
57 n be induced by Vg1), a second inhibition by Cerberus from the underlying hypoblast, and finally a la
58 g that previous studies, which analyzed frog Cerberus function, may not accurately describe the funct
59                                  The Xenopus cerberus gene encodes a secreted factor that is expresse
60 stine knot-containing factors including dan, cerberus, gremlin, prdc, and caronte.
61                          We demonstrate that CERBERUS has auto-ubiquitination activity in vitro and i
62 lls expressing homologues of the AVE markers cerberus, Hex and Hesx1.
63 7, Chordin, Lim1, Hnf3beta, Otx2, Goosecoid, Cerberus, Hex, Dickkopf1, and Crescent are all already e
64  determine the molecular activities of human Cerberus in TGF-beta family signaling.
65 oderm depends on Nodal-mediated induction of Cerberus in underlying endoderm, and that this pathway f
66           Finally, although misexpression of cerberus induced ectopic heads, it was unable to induce
67                                              CERBERUS interacted with and colocalized with both LjVPY
68                The underlying reason is that Cerberus is a complex, multifunctional protein: It binds
69                                              Cerberus is a key regulator of vertebrate embryogenesis.
70 sequence homology between frog and mammalian Cerberus is low, suggesting that previous studies, which
71                 We propose that, in Xenopus, cerberus is redundant to other bone morphogenetic protei
72 sses Hex and the putative head-inducing gene cerberus, is proposed to be equivalent to the mouse ante
73 ctivin B, BMP-6, and BMP-7, but not the frog Cerberus ligand BMP-2.
74  expression of anterior markers such as Hex, Cerberus-like and Lhx1.
75                            Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads
76 uced expression of Siamois, XTwin, Xnr3, and Cerberus mRNAs in a protein synthesis independent manner
77 and the overexpression of Wnt8, Siamois, and Cerberus mRNAs.
78 -autonomously, thus supporting the idea that Cerberus or another diffusible factor is an essential me
79 ve secreted protein that is 48% identical to cerberus over a 110-amino acid region.
80 esoderm, as indicated by their inhibition by Cerberus overexpression.
81 es in Athabasca Valles and its distal basin, Cerberus Palus, are actually composed of this lava.
82                   Protein related to DAN and cerberus (PRDC) is a secreted protein with a cystine kno
83  the structure of protein related to Dan and Cerberus (PRDC), a more potent BMP antagonist within the
84 onists, including protein related to DAN and cerberus (PRDC), have an unpaired cysteine that is thoug
85  BMP antagonists, Protein Related to Dan and Cerberus (PRDC).
86 us organizer: deep endoderm, which expressed cerberus; prechordal mesoderm, which showed overlapping
87                        Here we show that the cerberus protein functions as a multivalent growth-facto
88 y, morpholino-mediated specific knockdown of Cerberus reduced both endogenous cardiomyogenesis and ec
89          Here we describe the existence of a cerberus-related gene, Cerr1, in the mouse.
90        Strikingly, the molecular function of Cerberus remains poorly understood.
91 ganizer genes, including chordin, noggin and cerberus, required the activity of both the Wnt pathway
92 ist and Snail2 negatively regulate levels of cerberus RNA, which encodes a Nodal, bone morphogenic pr
93 nversely, LjVPY2 protein levels decreased in cerberus roots after rhizobial inoculation.
94 iously identified in imagery and topography (Cerberus Rupes and Valles Marineris).
95                                              Cerberus's anti-Nodal activity inhibits NF-kappaB activi
96  a process inhibited by the Nodal antagonist Cerberus-short (CerS).
97 njection of RNA encoding the nodal inhibitor Cerberus-short (CerS).
98 ocked by the extracellular Nodal antagonists Cerberus-Short and Lefty.
99 which mesoderm induction has been blocked by Cerberus-short, a reagent that specifically inhibits Nod
100             Injection of a Nodal antagonist, Cerberus-short, reduced the severity of head and axial d
101                        Our data suggest that CERBERUS stabilizes LjVPY1 and LjVPY2 within the trans-G
102                         Notably, full-length Cerberus successfully blocked ligand binding to type II
103                     In addition, full-length Cerberus suppressed breast cancer cell migration but the
104           Unlike the effect of misexpressing cerberus, these signals could not neuralise overlying ec
105          Downstream of Wnt, the head inducer Cerberus was identified as an effector that mediates ADA
106 undant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening.
107 s induced strongly by siamois, moderately by cerberus, weakly by Wnt8 and noggin, and not by chordin
108  molecules such as Chordin, Noggin, Xnr6 and Cerberus were not re-expressed in these embryos.
109  from that of the multifunctional antagonist cerberus, which completely abolishes mesoderm induction
110                             Co-expression of CERBERUS with LjVPY1 or LjVPY2 in N. benthamiana led to
111 n unforeseen role for the DAN family protein Cerberus within presumptive foregut endoderm as essentia
112 ed dorsoanterior endodermal markers, such as cerberus, Xhex-1 and Frzb, in animal cap ectoderm.

 
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