ライフサイエンスコーパス: cerebellar nuclei

1 es at the injection sites (thalamus and deep cerebellar nuclei).

2 ntrols excitatory synaptic plasticity in the cerebellar nuclei.

3 ibition of cerebellar output neurons in deep cerebellar nuclei.

4 nhibits output from connected regions of the cerebellar nuclei.

5 inhibition of the inferior olive by the deep cerebellar nuclei.

6 ate from distinct output channels within the cerebellar nuclei.

7 ible selection of signals for output to deep cerebellar nuclei.

8 All injections labeled the deep cerebellar nuclei.

9 in Purkinje cells, but increased in the deep cerebellar nuclei.

10 ls can drive synaptic plasticity in the deep cerebellar nuclei.

11 strengthening of excitatory synapses in the cerebellar nuclei.

12 thout directly affecting neurons in the deep cerebellar nuclei.

13 ia nigra pars reticulata, pallidum, and deep cerebellar nuclei.

14 ced hyperexcitability of neurons in the deep cerebellar nuclei.

15 in the olfactory bulb, red nucleus, and deep cerebellar nuclei.

16 the cerebellar cortex and in the lower deep cerebellar nuclei.

17 ds located medially and in some cells of the cerebellar nuclei.

18 ons vulnerable to weaver, including the deep cerebellar nuclei.

19 learning in the pcd mice is mediated by the cerebellar nuclei.

20 it is expressed in Purkinje neurons and deep cerebellar nuclei.

21 r nuclei, inferior olivary complex, and deep cerebellar nuclei.

22 xtracerebellar structures by way of the deep cerebellar nuclei.

23 in neurons of the hippocampal formation and cerebellar nuclei.

24 lower motor neurons and neurons of the deep cerebellar nuclei.

25 CP-MS revealed gadolinium depositions in the cerebellar nuclei.

26 y disinhibit the output activity of the deep cerebellar nuclei.

27 reading throughout the cerebellar cortex and cerebellar nuclei.

28 change in rostrocaudal expression among the cerebellar nuclei.

29 ivity in both the cerebellar cortex and deep cerebellar nuclei.

30 laterals within the spinal cord, medulla, or cerebellar nuclei.

31 laterals within the spinal cord, medulla, or cerebellar nuclei.

32 both Purkinje cells and neurons of the deep cerebellar nuclei.

33 luence on candidate coding strategies in the cerebellar nuclei.

34 ellar ataxia type 3 is not restricted to the cerebellar nuclei.

35 the cerebellar cortex but also involved the cerebellar nuclei.

36 terminals were found variably in all of the cerebellar nuclei.

37 t axonal growth and synapse formation in the cerebellar nuclei.

38 layer, granule cell layer, and region of the cerebellar nuclei.

39 cally -distinct neurons in the anterior deep cerebellar nuclei (aDCN) that are activated by feeding o

40 sion at synapses from Purkinje cells to deep cerebellar nuclei and at vestibular synapses in mice.

41 ar cortex retrogradely labeled somata in the cerebellar nuclei and boutons in the ventrolateral thala

42 discrete populations of neurons in the deep cerebellar nuclei and brainstem vestibular nuclei.

43 solved adaptation-driven GABA changes at the cerebellar nuclei and cerebellar cortex in the left and

44 vity, concomitantly increased signals in the cerebellar nuclei and cortex are consistent with finding

45 mossy fibers uniformly collateralize to the cerebellar nuclei and cortex underlies classic models of

46 ht-hand movements increase GABA in the right cerebellar nuclei and decreases GABA in the left.

47 /40 pS'--openings) in some patches from deep cerebellar nuclei and dorsal horn neurones.

48 ervals between the inhibitory input from the cerebellar nuclei and excitatory input from the mesodien

49 rgic premotor projection neurons in the deep cerebellar nuclei and GABAergic neurons that feed back t

50 i, and the rhombic lip, which generates deep cerebellar nuclei and granule cells.

51 observed retrogradely labeled somata in the cerebellar nuclei and mossy fiber terminals in the cereb

52 Cerebellar nuclei and neighboring white matter displayed

53 rom layers four and five of the cortex, deep cerebellar nuclei and other localized brain regions.

54 ivity are abolished following lesions of the cerebellar nuclei and since hippocampal lesions prevent

55 hypothalamus, midbrain, pons, medulla, deep cerebellar nuclei and spinal cord, with tau-immunoreacti

56 The specific role of deep cerebellar nuclei and the cerebellar cortex in eyeblink

57 lized to specific areas within both the deep cerebellar nuclei and the cerebellar cortex.

58 In the vestibular and cerebellar nuclei and the dorsal medial superior tempora

59 ect to the corticonuclear projections to the cerebellar nuclei and the functional connections of the

60 GABA changes, we found that GABA in the left cerebellar nuclei and the right cerebellar nuclei diverg

61 1 (Rcrus1) and posterior vermis through the cerebellar nuclei and ventromedial thalamus and culminat

62 cerebellar Purkinje cells and neurons in the cerebellar nuclei and vestibular nuclei of the Long-Evan

63 anscription factors define precursors of the cerebellar nuclei, and both Purkinje cells and granule n

64 thymic epithelium, pontine nuclei, fastigial cerebellar nuclei, and cerebral cortex.

65 Neurons in the cerebellar cortex, cerebellar nuclei, and inferior olive (IO) form a trisyn

66 onents simulating cerebellar cortex and deep cerebellar nuclei, and it received input from a middle t

67 ion was detected in the superior colliculus, cerebellar nuclei, and subpopulations of the medulla obl

68 iosis and vacuolation of neurons in the deep cerebellar nuclei, and the severe vacuolation of the cel

69 forebrain, the vestibular complex, the deep cerebellar nuclei, and the trapezoid body, a pattern tha

70 r nuclei, to the dorsolateral regions of the cerebellar nuclei, and to lateral regions of the superio

71 ing in the cerebellar cortex versus the deep cerebellar nuclei; and (4) negative feedback from the ce

72 roups; the intermediate, medial, and lateral cerebellar nuclei; and the nodulus, the uvula, and the p

73 The projection neurons of the deep cerebellar nuclei are especially altered.

74 In contrast, targeted neurons in the deep cerebellar nuclei are known to unambiguously encode eith

75 tor recovery, and lesions affecting the deep cerebellar nuclei are not fully compensated at any devel

76 Data on cerebellar nuclei are sparse.

77 Together, these data indicate that the cerebellar nuclei are under afferent control independent

78 ied to the thalamus from both vestibular and cerebellar nuclei, are positioned for distribution to wi

79 ormed by cerebellar Purkinje cells onto deep cerebellar nuclei as a model system, we confirm that Neu

80 es motor disease phenotypes and identify the cerebellar nuclei as a therapeutic target for surgical i

81 tomy, ruling out both the cerebellum and the cerebellar nuclei as afferent sources.

82 immunolabeled axons terminated in all of the cerebellar nuclei as well as in the lateral and superior

83 uronal soma degeneration in the thalamus and cerebellar nuclei as well as striatum.

84 n a little-studied feedback pathway from the cerebellar nuclei back to the cerebellar cortex.

85 o a Purkinje cell or onto a cell in the deep cerebellar nuclei become eligible for plasticity only af

86 Purkinje cells (PCs) primarily project to cerebellar nuclei but also directly innervate the brains

87 Fibers traversed the medial and intermediate cerebellar nuclei, but terminals appeared only occasiona

88 Abnormal activity in the cerebellar nuclei can be used to predict motor symptoms

89 segment of the globus pallidus (GPi) and the cerebellar nuclei (Cb) to the thalamus in the monkey, we

90 (M1(L5)), while another arises from the deep cerebellar nuclei (Cb).

91 KEY POINTS: Large premotor neurons of the cerebellar nuclei (CbN cells) integrate synaptic inhibit

92 ABSTRACT: Large projection neurons of the cerebellar nuclei (CbN cells), whose activity generates

93 ectly to large premotor neurons of the mouse cerebellar nuclei (CbN cells).

94 Firing in the cerebellar nuclei (CbN) inversely correlated with disinh

95 Purkinje cell (PC) synapses onto cerebellar nuclei (CbN) neurons allow signals from the c

96 ntified circumscribed output channels of the cerebellar nuclei (CbN) that could confer tight function

97 Neurons of the cerebellar nuclei (CbN) transmit cerebellar signals to p

98 hese climbing fibres send collaterals to the cerebellar nuclei (CbN).

99 g, which alters the activity of their target cerebellar nuclei cells.

100 Transduction was evident in the deep cerebellar nuclei, cerebellar Purkinje cells, the brains

101 r, has multisynaptic connections through the cerebellar nuclei (CN) and thalamus to cortical regions,

102 The neurons of the three cerebellar nuclei (CN) are the primary output neurons of

103 Cerebellar nuclei (CN) neurons serve as the primary outp

104 t inhibitory GABA-glycinergic neurons of the cerebellar nuclei (CN) project profusely into the cerebe

105 The principal neurons of the cerebellar nuclei (CN), the sole output of the olivo-cer

106 what extent modulation of neuronal firing in cerebellar nuclei (CN), which are anatomically in an adv

107 Purkinje neurons, granule cells, and in the cerebellar nuclei (CN).

108 g the factors that shape the activity of the cerebellar nuclei (CN).

109 Results suggest that lateral deep cerebellar nuclei contribute to visuospatial processing

110 Neurons of the cerebellar nuclei convey the final output of the cerebel

111 The thalamus is a major direct target of the cerebellar nuclei, conveying cerebellar signals to the c

112 tation-driven GABA fluctuations in the right cerebellar nuclei correlated with adaptation performance

113 tation-driven GABA fluctuations in the right cerebellar nuclei correlated with adaptation performance

114 ibition of the cerebellar cortex on the deep cerebellar nuclei could treat oculopalatal tremor.

115 ditary ataxia to test the potential of using cerebellar nuclei DBS plus physical activity to restore

116 buted among many unlabeled cells in the deep cerebellar nuclei (DCbN).

117 le low concentrations were found in the deep cerebellar nuclei (DCN) (30 ng/g [95% CI: 20, 41]).

118 We find that in mice the deep cerebellar nuclei (DCN) and vestibular nuclei (VN) are t

119 nes of evidence have indicated that the deep cerebellar nuclei (DCN) are a site of memory storage for

120 Neurons of deep cerebellar nuclei (DCN) are spontaneously active, and di

121 The deep cerebellar nuclei (DCN) are the main output centers of t

122 The deep cerebellar nuclei (DCN) are the major output of the cere

123 n addition, we evaluated the use of the deep cerebellar nuclei (DCN) as a site for injection to facil

124 erebellum, PNNs are found around large, deep cerebellar nuclei (DCN) neurons and Golgi neurons and ar

125 components of the neuropil in the four deep cerebellar nuclei (DCN) of the rat's brain.

126 Inhibitory projection neurons in the deep cerebellar nuclei (DCN) provide GABAergic input to neuro

127 ay be initiated by hyperexcitability of deep cerebellar nuclei (DCN) secondary to loss of inhibitory

128 amatergic projection neurons within the deep cerebellar nuclei (DCN) that provide the primary cerebel

129 hin the mature fastigial pathway of the deep cerebellar nuclei (DCN), a region critical for balance a

130 Purkinje neurons and the neurons of the deep cerebellar nuclei (DCN), a site that has been implicated

131 inently expressed around neurons of the deep cerebellar nuclei (DCN), but their role in adult cerebel

132 ive to several brain regions, including deep cerebellar nuclei (DCN), globus pallidus, and thalamus.

133 ncy bursting activity in neurons of the deep cerebellar nuclei (DCN), which comprise the bulk of cere

134 hat received linear GBCAs showed higher deep cerebellar nuclei (DCN)-to-brainstem SI ratios compared

135 on was examined with an emphasis on the deep cerebellar nuclei (DCN).

136 ion is rebound firing in neurons of the deep cerebellar nuclei (DCN).

137 terior parietal cortex (area 5) and the deep cerebellar nuclei (DCN).

138 cluding in our study the neurons of the deep cerebellar nuclei (DCN).

139 Tetrode recordings in the cerebellar nuclei demonstrate that focal stimulations of

140 in the left cerebellar nuclei and the right cerebellar nuclei diverged, although GABA change from ba

141 hat the classic cerebellar outputs, the deep cerebellar nuclei, do not directly project there.

142 changes in the left compared with the right cerebellar nuclei driven by both simple movement and mot

143 f learning, and that there is a shift to the cerebellar nuclei during later stages.

144 al and cell-physiological changes within the cerebellar nuclei during learning.

145 hrony may shape the output of neurons in the cerebellar nuclei either via powerful inhibition by Purk

146 (DRN) send projections to the fastigial deep cerebellar nuclei (fDCN) and that photostimulation of 5H

147 us, contralateral cerebellar cortex and deep cerebellar nuclei (FDR q < 0.05).

148 Neurons in the cerebellar nuclei fire at accelerated rates for prolonge

149 Neurons of the cerebellar nuclei fire spontaneous action potentials bot

150 and their postsynaptic target neurons in the cerebellar nuclei, fire action potentials at high, susta

151 uclei or by the combined action of inputs to cerebellar nuclei from mossy fiber collaterals and incom

152 We conclude that the deep cerebellar nuclei have a bilateral movement representati

153 Neurons of the cerebellar nuclei have basal firing rates of 10-20 Hz, d

154 Reversible inactivations of the cerebellar nuclei have directly implicated the cerebellu

155 Whereas cerebellar nuclei have long been thought to be preserved

156 For example, in the deep cerebellar nuclei, Hebbian patterns of coincident synapt

157 d between the cerebellar cortex and the deep cerebellar nuclei; (ii) the cerebellar cortex plays a sp

158 rtance of the cerebellar cortex and the deep cerebellar nuclei in eyeblink conditioning is unclear an

159 , called eurydendroid neurons (ENs) in fish (cerebellar nuclei in mammals).

160 imaging allowed depiction of atrophy of the cerebellar nuclei in patients with Friedreich's ataxia a

161 ed imaging was used to assess atrophy of the cerebellar nuclei in patients with spinocerebellar ataxi

162 According to one concept, SLRs originate in cerebellar nuclei in response to direct inputs from coll

163 gically inhibiting the erratic output of the cerebellar nuclei in the mutant mice improved movement.

164 ve rise to both cerebellar neurons and extra-cerebellar nuclei in ventral hindbrain.

165 suggest that prolonged rebound firing in the cerebellar nuclei in vivo is most likely to occur when G

166 he parabrachial, lateral lemniscal, and deep cerebellar nuclei, in addition to cerebellar granule neu

167 prising the inferior olive, vermis, and deep cerebellar nuclei including the dentate nucleus during a

168 Purkinje cells inhibit diverse cells in the cerebellar nuclei, including small GABAergic nucleo-oliv

169 ut strikingly similar to neurons in the deep cerebellar nuclei, indicating a common role for intrinsi

170 ralis (VPLo) and nucleus X (X) following the cerebellar nuclei injections.

171 Cerebellar nuclei integrate high-frequency information f

172 the output structures of the cerebellum, the cerebellar nuclei, integrate their inputs and influence

173 tentiation (LTP) of mossy fiber EPSCs in the cerebellar nuclei is controlled by synaptic inhibition f

174 ssy fiber varicosities in these parts of the cerebellar nuclei is positively correlated with the ampl

175 The muscimol infusions inactivated the cerebellar nuclei, lateral anterior lobe, crus I, rostra

176 In neurons of the cerebellar nuclei, long-term potentiation of EPSCs is in

177 ng microelectrode penetrations into the deep cerebellar nuclei (mainly nucleus interpositus) of monke

178 tibular signals from the vestibular and deep cerebellar nuclei may be important components of further

179 that can be achieved in this way in the deep cerebellar nuclei may be particularly important to allow

180 that neurons of the mouse medial (fastigial) cerebellar nuclei (mCbN), which fire spontaneously with

181 with relative increases in perfusion in deep cerebellar nuclei (medial, interposed, lateral), thalamu

182 rgely to the olfactory bulbs, midbrain, deep cerebellar nuclei, medulla, and spinal cord.

183 re, I investigated the Purkinje cell to deep cerebellar nuclei neuron synapses (PC_DCNs), which displ

184 homeobox genes En1 and En2 in the excitatory cerebellar nuclei neurons (eCN) leads to reduced postnat

185 At synapses from Purkinje cells to deep cerebellar nuclei neurons (PC-->DCN), light- and electri

186 ls could explain the responses of these deep cerebellar nuclei neurons across all self-motion conditi

187 rrelation between the average firing rate of cerebellar nuclei neurons and tremor power.

188 receptor-mediated monosynaptic IPSPs in deep cerebellar nuclei neurons by stimulation of Purkinje cel

189 ological modifications of synaptic inputs to cerebellar nuclei neurons can facilitate learning.

190 al output, the Purkinje cells, on identified cerebellar nuclei neurons in vivo in male mice.

191 neurotransmitter release in projections from cerebellar nuclei neurons onto gigantocellular reticular

192 caudal cerebellar vermis Purkinje cells and cerebellar nuclei neurons selective for actual linear ac

193 kinje cell discharges depends on the type of cerebellar nuclei neurons targeted.SIGNIFICANCE STATEMEN

194 nown about the changes in synaptic inputs to cerebellar nuclei neurons that take place during EBC and

195 hap1(+/-) mice have fewer Purkinje cells and cerebellar nuclei neurons, the number of long-range exci

196 Unlike vestibular and deep cerebellar nuclei neurons, where a mixture of responses

197 cells have abnormal firing patterns and that cerebellar nuclei neurons, which connect the cerebellum

198 represented by changes in the firing rate of cerebellar nuclei neurons.

199 kinje cells (which possess NR1 and 2D), deep cerebellar nuclei (NR1, 2A, 2B and 2D) and spinal cord d

200 unoreactivity in both the vestibular and the cerebellar nuclei of pigeons (Columba livia) and humming

201 usion Increased signal intensity in the deep cerebellar nuclei of rats persists for at least 1 year a

202 immunoreactive fibers were found in all four cerebellar nuclei of the opossum.

203 t are excited by increased tonic activity in cerebellar nuclei or by the combined action of inputs to

204 onjugated to horseradish peroxidase into the cerebellar nuclei or internal segment of the globus pall

205 e by Purkinje cells onto neurons in the deep cerebellar nuclei (PC to DCN synapses).

206 Within the cerebellar nuclei, PKC-delta-immunolabeled axons termina

207 ubstantia nigra and the lateral and internal cerebellar nuclei (present results).

208 The cerebellar nuclei primarily projected to posterior (VLp)

209 to early-born GrCs, while basal pontine and cerebellar nuclei provide more input to late-born GrCs.

210 IFICANCE STATEMENT Excitatory neurons in the cerebellar nuclei provide the primary output from the ce

211 ing bilateral lesions targeting lateral deep cerebellar nuclei, rats were subjected to a bridge test

212 Neurons of the cerebellar nuclei receive GABAergic input from Purkinje

213 Neurons of the cerebellar nuclei receive synaptic excitation from cereb

214 brain stimulation directed to the interposed cerebellar nuclei reduced dystonia-like postures in thes

215 directed to the Purkinje cell output in the cerebellar nuclei reduced tremor in freely moving mice.

216 Within the cerebellar nuclei, reductions were significant when comp

217 he final output stage of the cerebellum, the cerebellar nuclei, remains unknown.

218 e mice, which express Cre selectively in the cerebellar nuclei, retrogradely labeled somata in the in

219 rdings from the contralateral vestibular and cerebellar nuclei revealed elevated neuronal discriminat

220 -EDS) localization of gadolinium in the deep cerebellar nuclei showed ~ 100 nm electron-dense foci in

221 MRI) of the cerebellar cortex and interposed cerebellar nuclei simultaneously during delay eyeblink c

222 cell layer, and loss of neurons in the deep cerebellar nuclei; spheroids and loss of myelinated axon

223 ies of these two projection neurons from the cerebellar nuclei tailor them for differential integrati

224 , enhanced connectivity was observed between cerebellar nuclei, thalamus, and basal ganglia, whereas

225 the permanent discharge of neurons from the cerebellar nuclei that communicate cerebellar computatio

226 particularly observed in those parts of the cerebellar nuclei that have been implicated to be involv

227 d to pinpoint the exact location in the deep cerebellar nuclei that is necessary.

228 sions at atypical sites (e.g. thalamus, deep cerebellar nuclei) that are not typical for Lewy body-sp

229 messenger RNA levels were >/=30% in the deep cerebellar nuclei, the cerebellar cortex, inferior olive

230 er, decreases Purkinje-cell synapses on deep cerebellar nuclei, the major output pathway of cerebella

231 ion evolution at cell-type resolution in the cerebellar nuclei, the output structures of the cerebell

232 itive neurons in the most medial of the deep cerebellar nuclei, the rostral fastigial nucleus, were c

233 In the deep cerebellar nuclei, the temporal increases in PBR paralle

234 ain, including, but not limited to, the deep cerebellar nuclei, the trapezoid body, the red nucleus,

235 racer injections into a distal target of the cerebellar nuclei, the ventrolateral thalamus, we observ

236 This mechanism allows neurons in the cerebellar nuclei to adapt to long-lasting changes in sy

237 s to use optogenetic stimulation of the deep cerebellar nuclei to induce frequency-specific tremors i

238 x spike firing revealed that feedback in the cerebellar nuclei to inferior olive to Purkinje cell loo

239 the relative contribution of changes in the cerebellar nuclei to learning remains a subject of ongoi

240 Here we verified that the pathway from the cerebellar nuclei to the cerebellar cortex in mice inclu

241 A feedback projection from the cerebellar nuclei to the medial auditory thalamus was id

242 g of information also allows neurons of deep cerebellar nuclei to use a simple averaging mechanism to

243 matergic neurons, namely neurons of the deep cerebellar nuclei, unipolar brush cells, and the late co

244 ilar to those recorded in the vestibular and cerebellar nuclei using identical testing paradigms, but

245 scent protein (rAAV1.miS1eGFP) into the deep cerebellar nuclei using magnetic resonance imaging guide

246 brainstem motor nuclei, inferior olive, deep cerebellar nuclei, vestibular nuclear complex, nucleus o

247 , oculomotor nucleus, substantia nigra, deep cerebellar nuclei, vestibular nucleus, and the thalamus.

248 Atrophy of the cerebellar nuclei was most pronounced in spinocerebellar

249 hough GABA change from baseline at the right cerebellar nuclei was not different from zero at the gro

250 The volume of the cerebellar nuclei was reduced in the three patient group

251 m excitatory parvalbumin-positive neurons in cerebellar nuclei was sufficient to generate an action t

252 ior to E12.5, with the exception of the deep cerebellar nuclei, we find that Math1 cells migrate out

253 After AAV.miS1 delivery to deep cerebellar nuclei, we unexpectedly observed cerebellar t

254 ing and AT2 receptor mRNA levels in the deep cerebellar nuclei were also not affected by 3-acetylpyri

255 cerebellar white matter and within the deep cerebellar nuclei, where neuron loss also occurred.

256 ed in the putamen, globus pallidus, and deep cerebellar nuclei, where the most dense areas of 8B3 imm

257 of Purkinje-cell axon terminals in the deep cerebellar nuclei, whereas the dendritic trees grew to n

258 ts were found in the interpositus and medial cerebellar nuclei wherein fluorodeoxyglucose uptake incr

259 synaptic transmission with tetanus toxin in cerebellar nuclei, which also reversed the tremor phenot

260 Purkinje cells target the deep cerebellar nuclei, which are the output of the cerebellu

261 projection to most of the IO arises from the cerebellar nuclei, which are themselves subject to stron

262 tively promote firing in neurons in the deep cerebellar nuclei with remarkable speed and precision.

263 P appears to match somatotopic maps of these cerebellar nuclei with the somatotopic map of projection

264 nce predict that their target neurons in the cerebellar nuclei would be largely inhibited unless Purk

265 made from Purkinje cells onto neurons in the cerebellar nuclei, yet little has been known about the s