ライフサイエンスコーパス: cerebellum

1 also aversive processing (insular cortex and cerebellum).

2 subcortical network (subthalamic nucleus and cerebellum).

3 motor function (e.g. amygdala, hippocampus, cerebellum).

4 ritical events for normal development of the cerebellum.

5 rks that fine-tune the spiking output of the cerebellum.

6 rontal regions, the inferior olives, and the cerebellum.

7 regions and white matter, and lowest in the cerebellum.

8 he pathophysiology of diseases involving the cerebellum.

9 substructure and projection patterns of the cerebellum.

10 s in SC, 12.6% were also dysregulated in the cerebellum.

11 ephalon, cerebral cortex, basal ganglia, and cerebellum.

12 rkinje cell synapses that dominate the adult cerebellum.

13 nset BBB disruption (72 hours post-blast) in cerebellum.

14 ependence of processing in the neocortex and cerebellum.

15 erebellar projections to every lobule of the cerebellum.

16 rum semiovale (CS), high convexity (HC), and cerebellum.

17 ion and relevance of OPRM1 expression in the cerebellum.

18 enriched at synaptic specializations in the cerebellum.

19 ions of high transgene expression within the cerebellum.

20 5A, a protein that is highly abundant in the cerebellum.

21 tions and paradigm shifts in research on the cerebellum.

22 varies between brain regions, especially in cerebellum.

23 nd prevented CD4(+) T-cell infiltration into cerebellum.

24 tion of gene expression, most notably in the cerebellum.

25 ity and specific degenerative changes in the cerebellum.

26 hind brain and spinal cords but excluded the cerebellum.

27 ontal cortex, inferomedial temporal lobe and cerebellum.

28 ain in the molecular layer of the developing cerebellum.

29 put is represented at the input layer of the cerebellum.

30 in the pallidum, hypothalamus, brainstem and cerebellum.

31 ebellar nuclei, the output structures of the cerebellum.

32 gnals for both proteins were detected in the cerebellum.

33 ion was associated with the integrity of the cerebellum.

34 as well as in the basal ganglia and anterior cerebellum.

35 ions in regions, such as the spinal cord and cerebellum.

36 d early features in conditions affecting the cerebellum.

37 rol of high dimensional motor systems by the cerebellum.

38 in molecular layer interneurons of the mouse cerebellum.

39 of apoptotic cellular events in the prenatal cerebellum.

40 hood brain tumor arising from the developing cerebellum.

41 variability between the cerebral cortex and cerebellum.

42 rentiated tissues, with the exception of the cerebellum.

43 synapses in the molecular layer of the mouse cerebellum.

44 ignant paediatric brain tumour occurs in the cerebellum.

45 s are accommodated by different parts of the cerebellum.

46 precursors (GCPs) during development of the cerebellum.

47 egulates processing of sensory inputs in the cerebellum.

48 sion of identified genes was enriched in the cerebellum.

49 from 0.55 in the white matter to 0.98 in the cerebellum.

50 ocortex, amygdala, hippocampus, striatum and cerebellum.

51 ding the frontoparietal cortex, caudate, and cerebellum.

52 little is known about CB1R in the developing cerebellum.

53 st in the olfactory bulb, dentate gyrus, and cerebellum.

54 Here, we studied Lphn2 and Lphn3 in the cerebellum.

55 resulted in a 2-fold increase of IL-6 in the cerebellum.

56 gh a toxic gain-of-function mechanism in the cerebellum.

57 al networks formed between the brainstem and cerebellum.

58 phically mirrored in striatum, thalamus, and cerebellum.

59 (PNs) resulted in low PN firing rates in the cerebellum.

60 s the degradation of endocannabinoids in the cerebellum.

61 functional role for Caspr2 in the developing cerebellum.

62 omyelination and atrophy of the striatum and cerebellum.

63 ependence-associated variants is enriched in cerebellum.

64 kinase A (PKA) and Epac2 is abundant in the cerebellum.

65 t a role for MLIs in learning valence in the cerebellum.

66 part of both putamina, both thalami, and the cerebellum.

67 onal role during plasticity induction in the cerebellum.

68 ) and significantly greater than that in the cerebellum (0.17 ug . g(-1) +/- 0.03, P = .01) and white

69 ntal)) was calculated as (V(T)(frontal)/V(T)(cerebellum)) - 1.

70 05) and myo-inositol was reduced in the left cerebellum (34 voxels, CCLAV = 0.02).

71 brain injury was cerebral cortices (82%) and cerebellum (55%).

72 amine what effects acute manipulation of the cerebellum, a canonically motor structure, can have on t

73 cognitive domains.SIGNIFICANCE STATEMENT The cerebellum, a canonically motor-related structure, is be

74 most other mammals by their relatively large cerebellum, a feature that has been associated to echolo

75 rain tissues, i.e., hippocampus, cortex, and cerebellum, across various ages, i.e., juvenile, adult,

76 adigms, it is unclear whether any portion of cerebellum actively encodes and maintains mnemonic repre

77 bellum-brainstem parallel loops in which the cerebellum adjusts VSM signal flow and, in turn, receive

78 rafish and medaka did not, demonstrating the cerebellum alone not to be sufficient.

79 ), but it remained unclear as to whether the cerebellum alone was sufficient.

80 rly demonstrate that acute modulation of the cerebellum alters hippocampal function, and further illu

81 controls the development and function of the cerebellum and advances our understanding of how Caspr2

82 Analysis of the cerebellum and brainstem revealed a reduced granule cell

83 ncurrent cellular resolution recordings from cerebellum and cerebral cortex in unrestrained mice, dem

84 bout encoding of sensorimotor stimuli in the cerebellum and compare the in vivo coding properties of

85 ced size of the olfactory bulb, hippocampus, cerebellum and cortex besides reduced dentate gyrus neur

86 d, uptake was comparable to wild-type in the cerebellum and elevated in the cortex and hippocampus, r

87 iated with reduced volume of the right VIIIa cerebellum and elevated WM hyperintensity volume.

88 d to exacerbated atrophy of lobule VI of the cerebellum and exacerbated disease severity.

89 nal connectivity changes, especially between cerebellum and habenula, which correlate with decision o

90 pretectum and optic tectum) and motor areas (cerebellum and hindbrain), with similar visual area reti

91 ur results highlight a cognitive role of the cerebellum and its importance in motor planning.

92 tTA/rtTA lines that target expression to the cerebellum and limbs.

93 Positive connectivity to the cerebellum and negative connectivity to the somatosensor

94 roughout the telencephalon and deep into the cerebellum and optic tectum.

95 lation in the cerebral cortex, thalamus, and cerebellum and particularly widespread vacuolation in th

96 r radiologists and clinicians evaluating the cerebellum and possible pathological conditions that aff

97 GNIFICANCE STATEMENT Connections between the cerebellum and primary motor cortex (M1) are essential f

98 ude homologs of mammalian Zinc finger of the cerebellum and Purkinje cell protein 4 Drosophila DTB-sp

99 neuronal composition of the cerebral cortex, cerebellum and remaining brain structures of seven speci

100 maintaining the function of PCs in the adult cerebellum and reveal novel insights into mechanisms inv

101 ncerning the role of the connections between cerebellum and superior colliculus in previously observe

102 ctional connectivity between the ipsilateral cerebellum and the contralateral primary and bilateral s

103 ent knowledge about plaque morphology in the cerebellum and the fundamental role of the surrounding t

104 , ventricular system, hippocampus, amygdala, cerebellum and the gyrification index, all reveal that t

105 nstrated functional connectivity between the cerebellum and the medial prefrontal cortex (mPFC) in mi

106 nger the functional connectivity between the cerebellum and the somatosensory cortical areas.

107 relations with topographical regions of the cerebellum and their functional relations with areas in

108 directly from thin tissue sections of human cerebellum and upon use of low-energy collision-induced

109 brafish embryos, sections from the mammalian cerebellum and whole kidney, and use the reconstructed t

110 rotein level was greater in the hippocampus, cerebellum, and brainstem and APP protein level was grea

111 dissected into frontal cortex, hippocampus, cerebellum, and brainstem.

112 or of the elements of the spectrum, i.e. the cerebellum, and discuss its role in FCMTE, according to

113 tractions, gray matter (GM) integrity of the cerebellum, and disease severity using the International

114 ling in a subset of neurons in optic tectum, cerebellum, and hindbrain.

115 nhibitory interneuron loss in the cortex and cerebellum, and leads to motor deficits and seizures.

116 yrus, left thalamus, bilateral insula, right cerebellum, and right superior frontal gyrus, compared w

117 r movement control: the cerebral cortex, the cerebellum, and the basal ganglia.

118 iminutive cerebral cortices, which makes the cerebellum appear relatively large.

119 s suggest that the intrinsic dynamics of the cerebellum are intimately tied to day-by-day changes in

120 These results also further implicate the cerebellum as a brain region vulnerable to blast-induced

121 g potential values were calculated using the cerebellum as a reference region.

122 activity in a cerebral region to that in the cerebellum as a reference) between the two groups and to

123 g the simplified reference tissue model with cerebellum as reference tissue.

124 Purkinje cells (P-cells) in the mid-lateral cerebellum as the monkey learned to associate one arbitr

125 zed uptake value ratio (SUVR) with the whole cerebellum as the reference region.

126 aracteristics and functional behavior in the cerebellum as well as their relations with the brain is

127 ly in granule cell progenitors (GCPs) in the cerebellum, as was shown in Jdp2-promoter-Cre transgenic

128 spread reward-related cognitive input to the cerebellum, as well as new studies that have characteriz

129 ctures, such as the primary motor cortex and cerebellum, as well as the contribution of abnormal sens

130 We assessed functional activity of the cerebellum associated with motor, language, and memory c

131 ased network synchronization in the insular, cerebellum, basal ganglia, thalamus, operculum, frontopa

132 The cerebral cortex and cerebellum both play important roles in sensorimotor pro

133 study was to assess IS concentrations in the cerebellum, brainstem, cortex, hypothalamus, and striatu

134 lude that pOKR is acquired through recurrent cerebellum-brainstem parallel loops in which the cerebel

135 (q) proteins and PLC in the hypothalamus and cerebellum but not in cortex.

136 N play a key role in scaling the size of the cerebellum by influencing the survival of their Purkinje

137 olive neuron to influence the output of the cerebellum by synchronously suppressing the firing of po

138 n rhythm, supporting the hypothesis that the cerebellum can be biased to support these distinct cogni

139 lastic neuronal tissue in the brain stem and cerebellum can become epileptogenic in pediatric patient

140 l function, and further illustrates that the cerebellum can influence cognitive domains.SIGNIFICANCE

141 ebellar circuitry is altered and whether the cerebellum can serve as a therapeutic target to rectify

142 , hippocampus, amygdala, insular, cingulate, cerebellum, caudate, basal-forebrain, and thalamus areas

143 , these data support a view of the neocortex-cerebellum circuit as a joint dynamic system both in cla

144 The cerebellum contains the vast majority of neurons in the

145 Based on these findings, we propose that the cerebellum contains within itself a parallel but separat

146 ependent learning.SIGNIFICANCE STATEMENT The cerebellum contributes to movements through signals gene

147 kers indicative of reactive microglia in the cerebellum, cortex and hippocampus relative to germ-free

148 We examined the cerebellum, cortex, and hippocampus of both groups of co

149 adiography confirmed increased uptake in the cerebellum, cortex, hippocampus, striatum, and hypothala

150 New evidence suggests that the cerebellum could learn to do both.

151 rchical processing framework, applied to the cerebellum, could elucidate cerebellar contributions to

152 ctivity between left PCC and right posterior cerebellum (Crus I and II) was reduced in both groups of

153 s deficits in learning and memory, including cerebellum-dependent delay eyeblink conditioning.

154 a deficit in delay eyeblink conditioning, a cerebellum-dependent form of learning.

155 in sensorimotor integration associated with cerebellum-dependent learning.SIGNIFICANCE STATEMENT The

156 granule-cell-specific CB1KOs display normal cerebellum-dependent locomotor coordination and learning

157 ibution (V(T)) in the frontal cortex and the cerebellum derived from a kinetic analysis using MA1.

158 rgic neurons in the fastigial nucleus of the cerebellum does not alter hippocampal seizures in a mous

159 The cerebellum drives motor coordination and sequencing of a

160 he metabolic interrogation of the developing cerebellum during the early postnatal period after prete

161 a distributed set of regions, including the cerebellum, early visual cortex, and higher-order visual

162 lude: scarcely rounded cerebral hemispheres, cerebellum exposed in dorsal view with little superimpos

163 d peripheral immune cell infiltration in the cerebellum following blast exposure.

164 rkably, a similar shape is observed in human cerebellum from demented patients.

165 g., breast cancer) tumors, as well as on the cerebellum from tumors such as medulloblastoma and epend

166 erent brain sub-regions, including midbrain, cerebellum, frontal cortex, and pons.

167 .001), parietal lobe (g = -0.73; p = 0.053), cerebellum (g = -1.25; p < 0.001) and hippocampus (g = -

168 tion would be a significant new role for the cerebellum given the ubiquity of map representations in

169 nation with atrophy of the basal ganglia and cerebellum (H-ABC) is a neurodegenerative disease due to

170 yelination with Atrophy of Basal Ganglia and Cerebellum (H-ABC), a rare hypomyelinating leukodystroph

171 Early postnatal Tmem67 mutant cerebellum had disrupted ciliogenesis and reduced respon

172 The human cerebellum has a protracted developmental timeline compa

173 However, the posterolateral cerebellum has also expanded greatly relative to non-hum

174 ile the functional organization of the human cerebellum has been characterized, the influence of sex

175 The cerebellum has been implicated in this predictive contro

176 While the cerebellum has been previously shown to be recruited by

177 neurodevelopmental disorders, and the adult cerebellum has one of the highest expression levels of C

178 The cerebellum has recently been implicated in diverse cogni

179 ctor effectively transduced in the cerebrum, cerebellum, heart, liver and sciatic nerves.

180 response in the BXD21/TyJ RI strain; (2) The cerebellum, hippocampus and striatum show increased leve

181 informative for the prediction included the cerebellum, hippocampus, amygdala and insular cortex.

182 we uncover have relevance to learning in the cerebellum, hippocampus, and cerebral cortex, as well as

183 hypometabolism associated with putaminal and cerebellum hypermetabolism, compatible with encephalitis

184 The mechanisms by which the cerebellum impacts seizures, however, are unknown.

185 ories of cerebellar functions posit that the cerebellum implements internal models for online correct

186 r the past 30 years has implicated the human cerebellum in a broad range of functions, including moto

187 d three-dimensional plaque morphology in the cerebellum in APP/PS1 transgenic mouse, as a model of AD

188 Recently, the involvement of cerebellum in ASDs has been suggested, but the underlyin

189 r, corresponding excitability changes in the cerebellum in associative learning, such as in trace or

190 ivo two-photon calcium imaging of the vermal cerebellum in awake behaving male and female mice to rec

191 is study also highlights the key role of the cerebellum in cognitive inhibition.

192 relatively enlarged number of neurons in the cerebellum in comparison to other brain structures.

193 n, and further support the importance of the cerebellum in driving affective behaviors that could con

194 putational evidence for a novel role for the cerebellum in dynamic sensorimotor map calibration, of p

195 ients, supporting the predictive role of the cerebellum in feedback control.

196 The role of the cerebellum in non-motor learning is poorly understood.

197 es conclusive evidence about the role of the cerebellum in predicting the sensory feedback of our mov

198 The selective neurodegeneration in the cerebellum in SCA17 raises the question of why ubiquitou

199 This suggests a prominent role for the cerebellum in the evolution of distinctively human behav

200 basal ganglia and between basal ganglia and cerebellum in the pathophysiology of movement disorders.

201 Given the significance of the cerebellum in voluntary movement, we then built a more c

202 a, insula, cingulate, caudate, thalamus, and cerebellum) in T2DM patients.

203 entate gyrus, hypothalamus, olfactory areas, cerebellum) in the whole-brain datasets.

204 tinct expression and function of CB1R in the cerebellum, in which endogenous or exogenous activation

205 enzyme Chd4 in granule neurons of the mouse cerebellum increases accessibility of gene regulatory si

206 The cerebellum influences motor control through Purkinje tar

207 rhythmic activity.SIGNIFICANCE STATEMENT The cerebellum interacts with several distinct large-scale b

208 erturbation of the lateral reticular nucleus-cerebellum internal feedback pathway in EphA4 knock-out

209 generators of the signals revealed that the cerebellum ipsilateral and contralateral to the tumor wa

210 The vermal cerebellum is a hub of sensorimotor integration critical

211 The cerebellum is a key brain region in a variety of neurode

212 Although the cerebellum is a key region implicated in ASD, it remains

213 line and blocking scans, indicating that the cerebellum is a suitable reference region.

214 The cerebellum is a target of alcoholism-related brain damag

215 There is compelling evidence that the human cerebellum is engaged in a wide array of motor and cogni

216 Sensorimotor integration in the cerebellum is essential for refining motor output, and t

217 , these results suggest that the ipsilateral cerebellum is fundamental in predicting self-generated t

218 ontroller with homogeneous architecture, the cerebellum is increasingly implicated in cognitive funct

219 We report that: (1) The cerebellum is more sensitive to antioxidant response in

220 assically thought of as a motor circuit, the cerebellum is now understood to contribute to a wide var

221 While the cerebellum is one of the brain areas most underestimated

222 The human cerebellum is thought to interact with distributed brain

223 Although the cerebellum is traditionally associated with balance and

224 lateral LM; the projection to the oculomotor cerebellum largely arises from the medial LM.

225 level and GM/WM density ratio of CS, HC, and cerebellum level were significantly lower in brain-dead

226 Finally, ATXN1[82Q ] transgenic mice-with cerebellum limited expression of mutant ATXN1-demonstrat

227 a subset of SCA6 with greater loss of GM in cerebellum lobule VI exhibit temporal invariance and mor

228 transform intrinsic properties of the human cerebellum, making it capable of generating epileptic po

229 vements, emerging evidence suggests that the cerebellum may also harness a wider range of learning ru

230 itiate ictal activity, suggesting that human cerebellum may become capable of intrinsically generatin

231 To investigate how modulation of the cerebellum may impact the hippocampus, we stimulated two

232 demonstrating that in the Npc1(nmf164) mouse cerebellum, microglia in the molecular layer (ML) are ac

233 While decreased gray matter in right cerebellum might be a common brain structural abnormalit

234 that Gorlin NES cells formed tumors in mouse cerebellum mimicking human medulloblastoma.

235 y proposed, on theoretical grounds, that the cerebellum must regulate the dimensionality of its neuro

236 A recent study showed the cerebellum necessary to acquire this predictive OKR (pOK

237 alculated using the pseudo reference regions cerebellum, occipital cortex, and whole brain (WB) witho

238 ainstem and APP protein level was greater in cerebellum of blast vs control rats (p < 0.05).

239 ression of the external granule layer in the cerebellum of control and conditional SnoN knockout mice

240 g frequency of Purkinje neurons (PNs) in the cerebellum of Fragile X Mental Retardation 1 (Fmr1) knoc

241 Cerebellum of Jdp2-knockout (KO) mice contains lower num

242 We first report that, in the cerebellum of one-handers, the deprived hand region repr

243 membrane protein that is up-regulated in the cerebellum of patients with Parkinson's disease (PD) and

244 ed with an increased OPRM1 expression in the cerebellum of postmortem human brains (p = 4.7e-5).

245 plying the same methods to the neocortex and cerebellum of the macaque monkey, we found that its cere

246 et to determine whether the relatively large cerebellum of the small echolocating bats, and possibly

247 ISPR/Cas9-mediated deletion of Inpp5a in the cerebellum of wild-type mice leads to Purkinje cell dege

248 Involvement of the brainstem, cerebellum or both is common in MOGAD but usually occurs

249 Isolated attacks involving the brainstem, cerebellum or both were less frequent in MOGAD (9/39 (23

250 ed assay and (3) MRI lesion(s) of brainstem, cerebellum or both.

251 h the mRNA expression levels of PDE4D in the cerebellum (p-value = 0.04; m-value = 0.9), demonstratin

252 The cerebellum plays a crucial role in sensorimotor and asso

253 bellar processing.SIGNIFICANCE STATEMENT The cerebellum plays a key role in motor control and motor l

254 mogeneous character of its organization, the cerebellum plays differential computational roles in dis

255 ated that CBH extending more deeply into the cerebellum predicted adverse motor, visuomotor, and beha

256 otor control theories have proposed that the cerebellum predicts and cancels the sensory consequences

257 TMS over the cerebellum produced maximal CBI of PA-evoked EMG respons

258 ghts about the diversity and dynamism of the cerebellum provide a roadmap for the next decade of cere

259 , and sensorimotor processes (i.e., anterior cerebellum, r = 0.33) predicted greater total food and u

260 ociated virus (AAV)-expressing miR760 in the cerebellum reduces ATXN1 levels in vivo and mitigates mo

261 mPFC) in mice; showed that the mPFC mediates cerebellum-regulated social and repetitive/inflexible be

262 of both general growth defects and potential cerebellum-related neuronal defects.

263 rocessing and have critical implications for cerebellum's role in cognitive control.

264 In mice, we found that the cerebellum sends direct excitatory projections to the ve

265 The cerebellum showed the lowest V (T), consistent with prec

266 The cerebellum showed the most prominent effects, fitting wi

267 Within this network the cerebellum shows particularly strong and predictive pre-

268 e of mnemonic representations extends to the cerebellum.SIGNIFICANCE STATEMENT There is considerable

269 ion, 3 x30 minutes per week, we observed the cerebellum significantly changing its grey (volume incre

270 , and white matter in chimpanzee and macaque cerebellum slices.

271 ow that a gradient within the posterolateral cerebellum supports cognitive control with motor-adjacen

272 ional attenuation effect was observed in the cerebellum that is ipsilateral to the passive limb recei

273 ficant in the two CNS regions-the retina and cerebellum-that exhibit the most rapid rate of postnatal

274 ex and the two main excitatory inputs of the cerebellum: the mossy fibers and the climbing fiber coll

275 malformation (CM1), the displacement of the cerebellum through the foramen magnum into the spinal ca

276 es in positive-/negative-ion mode from mouse cerebellum tissue.

277 netic and molecular mechanisms that link the cerebellum to ASD, particularly during development, rema

278 r nuclei; and (4) negative feedback from the cerebellum to the inferior olive reduces the magnitude o

279 When expressed in cerebellum via adenoassociated virus (AAV) viral transfe

280 ol-exposed fetuses had reduced brainstem and cerebellum volume and water diffusion anisotropy in seve

281 associative networks, caudate, thalamus, and cerebellum was positively correlated with improvement in

282 al-temporal-occipital networks, putamen, and cerebellum was positively correlated with tic improvemen

283 lum of the macaque monkey, we found that its cerebellum was relatively much smaller, approximately 33

284 8)F-FDG uptake of the IC and PAC (reference: cerebellum) was assessed in 13 subjects with AHL using a

285 ks (insular-default mode network and insular-cerebellum) was found in the SD group compared to the NS

286 Out of 506 metabolites measured in cerebellum, we identified 186 metabolites that demonstra

287 Using a circuit-level model of the cerebellum, we link behavioral data to learning's neural

288 year, mean gadolinium concentrations in the cerebellum were 3.38 nmol/g (gadodiamide), 2.13 nmol/g (

289 Differences in the striatum and right cerebellum were also identified between rabbits in the t

290 TXN1[82Q] Purkinje neurons from the anterior cerebellum were found to degenerate earlier than those f

291 V(T) in the midbrain and cerebellum were positively correlated with PTSD total sy

292 histopathology changes were detected in the cerebellum, where progressive lysosomal storage, astrocy

293 parallel fibre-Purkinje cell synapses in the cerebellum, where they are involved in short- and long-t

294 lored the developmental origins of the human cerebellum, which has gained growing appreciation for it

295 zing-related midbrain regions project to the cerebellum, which is known to regulate rapid sensorimoto

296 stal and sex-specific effects, especially in cerebellum, which is vulnerable to early developmental s

297 presentations of conditioned learning in the cerebellum, which predicted susceptibility to later fear

298 hese studies identified abnormalities in the cerebellum, which primarily affected Purkinje cells (PCs

299 ved reduced Sirt1 activity in the SCA7 mouse cerebellum with NAD(+) depletion.

300 the brainstem, basal ganglia, neocortex, and cerebellum within 13 dpi, indicating acute synaptic inju