ライフサイエンスコーパス: chain elongation

1 d not affect charging but greatly attenuated chain elongation.

2 rearrangements of the nascent peptide during chain elongation.

3 ediates through pathways that require carbon-chain elongation.

4 ase (KS) domain that collaborate to catalyze chain elongation.

5 V(max), reflecting a defect in polyubiquitin chain elongation.

6 ur, takes place after ketosynthase-catalyzed chain elongation.

7 mplex displays increased processivity of RNA chain elongation.

8 rred straight-chain elongation over branched-chain elongation.

9 factor EF-Tu preventing any participation in chain elongation.

10 cterized with a single ACP for each cycle of chain elongation.

11 attenuated the UV-induced inhibition of DNA chain elongation.

12 parate gene, that catalyze discrete steps in chain elongation.

13 duction of the beta-ketothioester product of chain elongation.

14 oesters from solution onto FASs and PKSs for chain elongation.

15 synthesis by controlling the rate of peptide chain elongation.

16 s inhibition of both replicon initiation and chain elongation.

17 s were found to be equivalent substrates for chain elongation.

18 ins acting together to catalyze one round of chain elongation.

19 m thioester intermediates during siderophore chain elongation.

20 forming the uridylylated VPg primer for RNA chain elongation.

21 ACP domains in the hybrid module to catalyze chain elongation.

22 e, i-C(6)) can be produced via ethanol based chain elongation.

23 energy landscape develops late during apoMb chain elongation.

24 f the thiazoline moieties during siderophore chain elongation.

25 ion, and resulted in defects in in vitro DNA chain elongation.

26 CBV-TP were only moderate inhibitors of DNA chain elongation.

27 alylation in substrate selection and polySia chain elongation.

28 ccharide repeat units for ECA polysaccharide chain elongation.

29 e catalytic subunit of the polymerase during chain elongation.

30 CP1, even for the amide bond-forming step in chain elongation.

31 hing is more effective per surface unit than chain elongation.

32 porting mthPolB-catalyzed PCNA-dependent DNA chain elongation.

33 ibit protein translation by reducing peptide chain elongation.

34 anation and branching activity competed with chain elongation.

35 lymerase to DNA, resulting in processive DNA chain elongation.

36 replication, whereas ts-114 is defective in chain elongation.

37 pRNA synthesis normally but is deficient in chain elongation.

38 er concentrations of NTPs than did templated chain elongation.

39 y for the high processivity of EC during RNA chain elongation.

40 e transition from abortive to productive RNA chain elongation.

41 te (Site 2) is associated with polyubiquitin chain elongation.

42 sponsible for a specific round of polyketide chain elongation.

43 ed to accomplish twenty cycles of polyketide chain elongation.

44 ot stabilize or otherwise activate 3Dpol for chain elongation.

45 appropriate for retention of DNA during RNA chain elongation.

46 rase to the template allowing processive DNA chain elongation.

47 oxyribonucleotides or ribonucleotides during chain elongation.

48 of hydroxyurea, a drug known to inhibit DNA chain elongation.

49 canonical Site 2 responsible for subsequent chain elongation.

50 l and propanol were both highly suitable for chain elongation.

51 njugation to TIF-1gamma as well as poly-SUMO chain elongation.

52 djacent to the acceptor ubiquitin facilitate chain elongation.

53 esis to address the polarity of maltodextrin chain elongation.

54 scopy confirmed the polarity of maltodextrin chain elongation.

55 e2S to bind the APC/C and catalyze ubiquitin chain elongation.

56 e (KS) domain within each module to catalyze chain elongation.

57 ting Met to its 2-oxo acid for glucosinolate chain elongation.

58 pore, and into the ER lumen coincident with chain elongation.

59 nctive RING E3 features specifying ubiquitin chain elongation.

60 n length and linkage impact kinetic rates of chain elongation.

61 with the Cdc34 E2 Ub conjugating enzyme for chain elongation.

62 ngas fermentation effluent through microbial chain elongation.

63 ves as the acceptor for M+4 palmitoyl-CoA in chain elongation.

64 l structure is responsible for polyubiquitin chain elongation.

65 ues (K29, 48, 63R) involved in polyubiquitin chain elongation.

66 n of the C18 carbinol stereogenic center and chain elongation.

67 ineered to catalyze two successive rounds of chain elongation.

68 R513A mutant with a markedly reduced rate of chain elongation.

69 e synthetic direction and thus enable carbon-chain elongation.

70 O2 promoted statistically significant carbon-chain elongation across lipid classes, with the stronges

71 e (Lys-61) was shown to be essential for RNA chain elongation activity by purified enzyme; however, a

72 Our results suggest that 1) chain elongation activity is a useful and novel probe fo

73 n keto acids and alcohols by engineering the chain elongation activity of 2-isopropylmalate synthase

74 rtance of inter-module chain transfer versus chain elongation activity of some of these modules.

75 hout impairing the Ube2S-dependent ubiquitin chain elongation activity.

76 corresponding amino acids in FPPase enhanced chain-elongation activity, while similar mutations in th

77 tretches of messenger RNA and resume protein chain elongation after a "bypassed" region.

78 in a messenger sequence and resumes protein chain elongation after a "landing site" downstream of th

79 of the ubiquitination process and ubiquitin chain elongation after deneddylation.

80 in these cases, which would limit efficient chain elongation after insertion of a fluorinated monome

81 r RNA without translating and resume protein chain elongation after the bypassed region.

82 VC, suggesting that severe inhibition of DNA chain elongation and activation of the replication check

83 variants are characterized by pause-free RNA chain elongation and are resistant to RfaH action.

84 ule, participates in one round of polyketide chain elongation and associated chemical modifications,

85 complete cycle of polyketide or polypeptide chain elongation and associated functional group modific

86 omains necessary for each step of polyketide chain elongation and chemical modification, can be decon

87 rings revealed possible patterns of polymer chain elongation and cross-linking within the biopolymer

88 Enzymes that catalyze chain elongation and cyclopropanation are well studied,

89 Other information, such as chain elongation and desaturation, might also be derived

90 UEV domain to Rim8 interferes with ubiquitin chain elongation and directs Rim8 monoubiquitination.

91 advantages, such as facilitating the nascent chain elongation and enabling antibiotic resistance.

92 olecules undergo iterative processes such as chain elongation and functional group manipulation, are

93 that in addition to the canonical polyketide chain elongation and functionalization encoded by type I

94 ers focus on the reduction of ethanol use in chain elongation and improve the recovery efficiency of

95 all showed reduced in vivo rates of peptide-chain elongation and increased levels of precursor 23S r

96 These size increases were largely due to chain elongation and not to alterations in the ratio of

97 nnings of substrate association upon nascent chain elongation and processivity.

98 optical tweezers that allow operations like chain elongation and shortening.

99 hus that multiple substrates can be used for chain elongation and that this process is carried out by

100 ermined by a kinetic balance between nascent chain elongation and the transmission of the RNA signal

101 is then deacylated to provide substrates for chain elongation and/or desaturation.

102 Our findings indicate that two-carbon side-chain elongation and/or m-positioning of the hydroxyl gr

103 structed from farnesyl diphosphate synthase (chain elongation) and chrysanthemyl diphosphate synthase

104 We have been investigating two mutants, cel (chain-elongation) and chol-1 (choline-requirer), which a

105 s that are believed to be defective in xylan chain elongation, and suggests that IRX10 and IRX10-L al

106 qual number of DNA adducts in inhibiting DNA chain elongation ( approximately 7-fold in CEM cells).

107 DNA and RNA chain elongation are arrested at different locations on

108 ts that the majority of two-carbon units for chain elongation are derived from beta-oxidation of [1,2

109 Peptide chain elongation as measured by polymerization of Phe-tR

110 e KS-AT-KR(0) proteins were able to catalyze chain elongation as well as the intact parent module.

111 In this study, cytotoxicity and steady-state chain elongation assays indicate that hMLH1 or hMSH6 def

112 ink inhibited DNA replication by terminating chain elongation at 1-50 nucleotides before the cross-li

113 f new replicons but also reduced the rate of chain elongation at active replication forks.

114 pentasaccharide building block suitable for chain elongation at both ends.

115 saccharide is suitably protected for further chain elongation at positions 3, 4, and 6 of the termina

116 acid production from mixed organic waste via chain elongation at this current, early stage of technol

117 to be a combination of chain fluctuation and chain elongation attributable to RNA transcription.

118 ssisted translation, the transient degree of chain elongation becomes a relevant variable expected to

119 polymerase, not only in the catalysis of RNA-chain elongation but also in the activation of the enzym

120 second dehydratase, FabZ, functions in acyl chain elongation but cannot carry out the isomerization

121 tandem UBDs inhibit efficient polyubiquitin chain elongation but have no effect on initiation of ubi

122 that are specifically involved in ubiquitin chain elongation but whose roles in proteolysis remain s

123 at PKC activation is sufficient to cause GAG chain elongation, but both PKC and ERK activation are re

124 closely related NEIL2 alone does not affect chain elongation, but combined NEIL1/2 deficiency furthe

125 e formed acetate in turn stimulated straight chain elongation, but the resulting lower net acetate su

126 lization of 3'-hydroxyl termini as sites for chain elongation by 3D, and thereby stimulates RNA synth

127 Chain elongation by another addition of the aforemention

128 ed, FMdC became a poor substrate for further chain elongation by DNA polymerases, resulting in a term

129 ition of O-fucose but do impair carbohydrate chain elongation by Fringe.

130 tigated the role of EXTL2 in heparan sulfate chain elongation by gene silencing and overexpression st

131 i-EF-Tu antibodies similarly inhibit peptide chain elongation by P. aeruginosa ribosomes in the in vi

132 This allows a new round of protein chain elongation by placing the next mRNA codon in the A

133 A polymerase switch then allows chain elongation by proofreading-proficient pol delta an

134 re, we show that the RING-E3 APC/C catalyzes chain elongation by strongly increasing the affinity of

135 Mammalian SRP slows nascent chain elongation by the ribosome during targeting in vit

136 onucleotide operates as a primer for in situ chain elongation catalyzed by the Taq I polymerase.

137 ns to give a mixture of geranyl diphosphate (chain elongation), chrysanthemyl diphosphate (cyclopropa

138 zation, monofunctionalization, and efficient chain-elongation coupling of OEGs further enable the inc

139 emistry of the intermediates of a polyketide chain elongation cycle catalyzed by a DH-containing modu

140 and performing the first step in the peptide chain elongation cycle.

141 Four reactions--chain elongation, cyclopropanation, branching, and cyclo

142 ed from four fundamental coupling reactions: chain elongation, cyclopropanation, branching, and cyclo

143 n of the free ubiquitin pool, we expressed a chain elongation defective ubiquitin mutant (UbK48R), wh

144 The DNA chain elongation defects were partially repaired by addi

145 uctase domain, independent of the particular chain elongation domains that were used, thereby establi

146 nvolve looping out the Pt-GG adduct to allow chain elongation downstream of the adduct.

147 nd thus can modulate the rate of polypeptide chain elongation during translation.

148 r chlorination, one-carbon truncation during chain elongation, E-double bond formation and thiazole r

149 Nascent RNA structures may regulate RNA chain elongation either directly through interaction wit

150 egard, DCS is more similar to the isoprenoid chain elongation enzyme farnesyl diphosphate synthase, w

151 roteins generated by replacing segments of a chain-elongation enzyme with corresponding sequences fro

152 belongs to a genetically distinct family of chain elongation enzymes that install E-double bonds dur

153 l products are biosynthesized via successive chain-elongation events mediated by elaborate protein as

154 he cytomegalovirus and the human polypeptide chain elongation factor 1alpha (EF-1alpha) promoters in

155 vector in which the strong human polypeptide chain elongation factor 1alpha promoter drives a bicistr

156 ination of a subset of proteins by ubiquitin chain elongation factors (E4), represented by Ufd2p in S

157 Chain elongation fermentation can be used to convert org

158 ucts, thereby permitting reinitiation of DNA chain elongation following spontaneous termination event

159 ases (AtIPMDHs) play key roles in methionine chain-elongation for the synthesis of aliphatic glucosin

160 heximide and other inhibitors of polypeptide chain elongation "freeze" ribosomes on mRNA and prevent

161 During chain elongation glycosylation reactions no column chrom

162 beta-ketoacyl moiety formed at each round of chain elongation have been studied by engineering and ch

163 Those molecules produced by chain elongation have head-to-tail (regular) carbon skel

164 at incorporated nucleoside analogs terminate chain elongation if the resulting primer strand lacks a

165 igration by blocking hyaluronan synthesis or chain elongation impaired invasion of adjacent OSCC cell

166 n purified that specifically facilitates RNA chain elongation in a chromatin context; the properties

167 t disruption of lamin organization inhibited chain elongation in a dose-dependent fashion.

168 NA and, in UV-damaged cells, Tipin slows DNA chain elongation in active replicons.

169 Second, chain elongation in all hybrid modules tested was seriou

170 , EETs are substrates for beta-oxidation and chain elongation in endothelial cells and that there is

171 ntation of downstream products of fatty acyl chain elongation in the acylcarnitine pool during ischem

172 catalytic partners occurs in every cycle of chain elongation in the biosynthesis of fatty acids and

173 Chain shortening was accompanied by chain elongation in the synthesis of other long chain fa

174 e is limited insight into the versatility of chain elongation in view of different starting substrate

175 r completely interrupt a single round of RNA chain elongation in vitro.

176 ing 1 kg caproic acid from organic waste via chain elongation, in both a lab-scale and a pilot-scale

177 events use of the clamp by the polymerase in chain elongation, indicating that the polymerase has an

178 hains immobilized on ribosomes by antibiotic chain elongation inhibitors followed by detection of pur

179 acid was elongated with three synthetic Crp chain elongation intermediate analogues through ester bo

180 mployed to generate the tylactone hexaketide chain elongation intermediate that was accepted by the j

181 triketide analogue of the natural triketide chain elongation intermediate to cultures of S. coelicol

182 a hydrolytic chain release of the polyketide chain elongation intermediate.

183 ctive processing of the ACP-bound polyketide chain elongation intermediate.

184 tion of a 2-hydroxy acid moiety in the final chain elongation intermediate.

185 sized the natural pentaketide and hexaketide chain elongation intermediates as N-acetyl cysteamine (N

186 s function evaluated with a series of linear chain elongation intermediates in developing a novel che

187 ion of the unit A delta-hydroxy octadienoate chain elongation intermediates.

188 Chain elongation into medium-chain carboxylates, such as

189 d out by highly similar organisms for direct chain elongation irrespective of the substrate.

190 RNA chain elongation is a highly processive and accurate pro

191 Chain elongation is a process that produces medium chain

192 The machine is rapid: Peptide chain elongation is complete in hours.

193 In fact, chain elongation is controlled at a docking site remote

194 Adozelesin inhibition of nascent chain elongation is first observed at concentrations abo

195 synthase (DEBS) has yielded a model in which chain elongation is governed by interactions between the

196 Rather, the onset of RNA chain elongation is inhibited because TRIM25 prohibits t

197 The process of chain elongation is likely to be distinct from the proce

198 e LUBAC components, whereas linear ubiquitin chain elongation is realized by a specific interplay bet

199 f the ribosome in either chain initiation or chain elongation is still unknown.

200 Z-double bond isomers by FPP synthase during chain elongation is unexpected for a highly evolved enzy

201 racterization of both initiation and peptide chain elongation kinetics for cap-dependent translation.

202 wer net acetate supply rate towards straight chain elongation led to an increased selectivity towards

203 an N-terminal loading unit, seven polyketide chain elongation modules, and a carboxy terminator unit.

204 When (R)-[2-2H]IPP was a substrate for chain elongation, no deuterium was found in the chain el

205 However, one feature of RNA chain elongation not predicted by the model is that the

206 cetyl-CoA, which is subsequently used in the chain elongation of a second stearate molecule to form v

207 Chain elongation of DNA requires a sufficient supply of

208 Chain elongation of fatty acids is an important cellular

209 ynthesis (primary metabolism) and methionine chain elongation of glucosinolates (specialized metaboli

210 The committed step in the side chain elongation of methionine-derived aliphatic glucosi

211 PICS module 5+TE could catalyze the chain elongation of only the syn diketide (2S,3R)-4, whi

212 Chain elongation of palmitate to stearate appeared to oc

213 ll dimensions of the resulting spectrum, and chain elongation of sequential amino acids can be effect

214 rboxylic acid cycle (glutamate pool), and in chain elongation of stearate (peroxisomal pool).

215 esyl diphosphate synthase (FPPase) catalyzes chain elongation of the C(5) substrate dimethylallyl dip

216 ments suggested that this deficiency in pRNA chain elongation of the K241R mutant primase is unlikely

217 zyl ester to a solid support; (ii). stepwise chain elongation of the peptide by standard Fmoc/tBu sol

218 ide E3 ubiquitin ligase to promote ubiquitin chain elongation on a substrate.

219 es suggested K63-based ubiquitin linkage and chain elongation on EZH2 in response to TGF-beta.

220 ty of LUBAC, priming on a lysine on NEMO and chain elongation on the N terminus of the priming ubiqui

221 cts with an efficiency of 14-35% compared to chain elongation on undamaged DNA, which is second only

222 a dominant-negative ubiquitin that prevents chain elongation or by small interfering RNA directed ag

223 g genes at G1/S was fully independent of DNA chain elongation or initiation.

224 ity of a single catalyst for either a single-chain-elongation or a single-chain-termination event dur

225 The microbiome preferred straight-chain elongation over branched-chain elongation.

226 ck base pair or if it forces replicative DNA chain elongation past a mismatch before DNA polymerase c

227 ACID TRANSAMINASE4, which is involved in the chain elongation pathway of Met-derived glucosinolates.

228 branched-chain amino acids and/or in the Met chain elongation pathway, the initial steps towards the

229 e, the key enzyme for a proposed peroxisomal chain elongation pathway.

230 The methionine chain-elongation pathway is required for aliphatic gluco

231 ation, especially in combination with carbon chain elongation pathways.

232 eplication, with only a modest inhibition of chain elongation per se.

233 ), the processivity factor necessary for the chain elongation phase of DNA replication.

234 ce of CPPase aligns closely with that of the chain elongation prenyltransferase farnesyl diphosphate

235 Chain elongation prenyltransferases catalyze the additio

236 Further in situ chain elongation, prior final work up of the tandem proc

237 provide important new insights into the RNA chain elongation process and offer the prospect of under

238 The data suggest that the chain elongation process is localized on the outer surfa

239 Moreover, stability of the chain elongation process was evaluated by performing rep

240 ths observed, suggesting that the fatty acid chain elongation process was not affected.

241 etyl-lactosamine repeat as a key step of the chain elongation process.

242 ters introduced into the backbone during the chain elongation process.

243 ADPH generated the fully saturated triketide chain elongation product as a 5:3 mixture of (2S,4R)-2,4

244 ynthesized farnesyl diphosphate as the final chain elongation product, but their kinetic behavior var

245 in elongation, no deuterium was found in the chain elongation products.

246 . tridentata FPPase and CPPase belong to the chain elongation protein family (PF00348), a subgroup of

247 The value of the rRNA chain elongation rate in bacteria is an important physio

248 ependent methodologies show that the peptide chain elongation rate increases as a function of tempera

249 perature shift experiments show that peptide chain elongation rate increases immediately, which suppo

250 acement distribution, diffusion coefficient, chain elongation rate, and distribution of molecule numb

251 o acid sequence, its cotranslational nascent-chain elongation rate, and folding.

252 upled ribosomes, a 20% decreased polypeptide chain elongation rate, and increased resistance to the r

253 to known regions of the tunnel and measured chain elongation rates.

254 diates and directly uses acetyl-CoA for acyl-chain elongation (rather than first requiring ATP-depend

255 substantially less reactive than GPP in the chain elongation reaction and was an excellent competiti

256 enerate (3S)-beta-hydroxyacyl-ACP during the chain-elongation reaction of bacterial fatty acid biosyn

257 iphosphate synthase catalyzes the sequential chain elongation reactions between isopentenyl diphospha

258 rgoes two consecutive sets of alpha-ketoacid chain elongation reactions to produce alpha-ketosuberate

259 iosynthetic pathways that comprise iterative chain elongation, reduction, and dehydration reactions.

260 48 side chain can be positioned properly for chain elongation regardless of chain length.

261 e frequency of initiation events because DNA chain elongation remains practically unchanged.

262 ixed-disulfide intermediate is, upon further chain elongation, resolved, releasing the oxidized polyp

263 phate (ara-GTP), which acts to terminate DNA chain elongation, resulting in cell death.

264 tightly bound in a cavity distinct from the chain elongation site described for farnesyl pyrophospha

265 s (rosettes) and are thought to catalyze the chain elongation step in glucan polymerization.

266 that normally catalyzes the first polyketide chain elongation step of 6-dEB biosynthesis.

267 in Hus1-deficient cells reflected mainly the chain elongation step of DNA replication and was correla

268 er-unit selection and catalysis of the first chain elongation step.

269 alonyl-coenzyme A (mMCoA) are substrates for chain elongation steps carried out by the Rf PKS.

270 diketide analogues of the natural polyketide chain elongation substrates.

271 es involved in the membrane-bound fatty acid chain elongation system.

272 ein structure evolves during the polypeptide chain elongation that accompanies cotranslational protei

273 genin-labeled nucleotides as a substrate for chain elongation, the neo-synthetic DNA is labeled by an

274 Alternatively, during UB chain elongation, the RING does not bind UBE2S but rathe

275 of nucleotides downstream and resume protein chain elongation there.

276 ited to the transcription complex during RNA chain elongation through specific interactions with a DN

277 s revealed dramatic bathochromic shifts upon chain elongation, thus suggesting highly effective exten

278 ding the methyl-branched carbon, followed by chain elongation to 19 carbons.

279 n selectively during different iterations of chain elongation to afford structural diversity.

280 re, we utilized the carboxylate platform and chain elongation to produce n-butyric acid and n-caproic

281 er was necessary and sufficient to block RNA chain elongation, two interacting dimers of RTP were nee

282 d lowers the efficiency of clamp loading and chain elongation under conditions of elevated salt.

283 In addition to its roles in polypeptide chain elongation, unique cellular and viral activities h

284 is controlled at different interfaces during chain elongation versus chain transfer.

285 t these MID1 domain constructs facilitate Ub chain elongation via Lys63 of Ub.

286 seHAS has an intrinsic 2-fold faster rate of chain elongation (Vmax) than spHAS.

287 DNA chain elongation was also inhibited in a concentration-d

288 Chain elongation was the dominant activity during the N-

289 ansferase activity, a key enzyme for peptide chain elongation, was also significantly decreased.

290 ently, a novel biorefinery process, that is, chain elongation, was developed to convert mixed organic

291 detail the role of EXTL2 in heparan sulfate chain elongation, we tested the ability of the overexpre

292 electrons produced via oxidation routes and chain elongation were apparently utilized by hydrogenotr

293 hat cells have a mechanism for arresting DNA chain elongation when dNTP levels are not maintained abo

294 Ura individually interfered with nascent DNA chain elongation, whereas the three-drug combination pro

295 First, wild-type modules catalyzed chain elongation with comparable efficiency regardless o

296 lucose and increased fatty acid synthesis by chain elongation with either PGC-1alpha or -1beta expres

297 of 3-OPP and 4-OPP were similar to those for chain elongation with IPP and DMAPP.

298 replicase, DNA polymerase III holoenzyme, in chain elongation with the beta clamp demonstrate that up

299 emonstrated that BCAT6 can contribute to Met chain elongation with the triple mutant line lacking BCA

300 compounds and sugars into SCCAs, subsequent chain elongation with undistilled ethanol in beer, and h