ライフサイエンスコーパス: chalcone

1 ction of the flavylium ion back to the trans-chalcone.

2 critical role of SHP-1 in the action of this chalcone.

3 ro were predominantly CTAL and low levels of chalcone.

4 cetin, kaempferol, naringenin and naringenin chalcone.

5 s of the corresponding quinone methides with chalcones.

6 ared to normal breast cells than other known chalcones.

7 of gamma-butyrolactam onto the corresponding chalcones.

8 DDQ in the presence of silica to furnish the chalcones.

9 aldehydes and ethoxide to give a variety of chalcones 10a-k in excellent yield (82-99%) upon TFA cle

10 Oral administration of chalcone 16, at a concentration of 100 mg/kg of body wei

11 Transcription of chalcone 2'-O-methyltransferase (CHOMT), and 1,3-beta-D-

12 his study, using a novel chalcone derivative chalcone-24 (Chal-24), we identified a novel anticancer

13 We show that the compound, carbonitrile-chalcone 4, blocks the recruitment of eosinophils to the

14 d on the CXCL12-neutralizing small molecule, chalcone 4, which blocks binding of CXCL12 to CXCR4.

15 elo 'Inodorous Group') accumulate naringenin chalcone, a yellow flavonoid pigment.

16 s of a population segregating for naringenin chalcone accumulation followed by fine mapping and genet

17 n expressed, negatively regulates naringenin chalcone accumulation.

18 The chalcone alpha,beta-unsaturated ketone moiety seemed to

19 These chalcones also showed reduction in parasitemia and incre

20 his study, we report the identification of a chalcone analogue called Amt-87 that can significantly r

21 hmanial activities of a library of synthetic chalcone analogues have been examined.

22 in, chlorogenic acid, naringenin, naringenin chalcone and ascorbic acid have been obtained.

23 se to UV-B or Phoma medicaginis, whereas the chalcone and flavanone precursors of these compounds acc

24 zapentadienyl anion generated in situ from a chalcone and glycine ester is the key step of an efficie

25 id compounds; we also tested our findings on chalcone and nitrone data from the current literature.

26 hoxychalone), a new synthetic trifluorinated chalcone and Nrf2 agonist, for targeted pulmonary inhala

27 Although the models for the chalcone and stilbene series appeared slightly different

28 oding a polyketide synthase with homology to chalcone and stilbene synthases from plants.

29 5-10 mg/kg fresh weight), mainly naringenin chalcone and the flavonol rutin, a quercetin glycoside.

30 icity were investigated among a series of 44 chalcones and analogues (1,3-diarylpropenones), by evalu

31 loaddition, for example, the dimerization of chalcones and cinnamic acid derivatives, is a unique str

32 yrrole-2-carboxylates and -carboxamides from chalcones and glycine esters or amides.

33 direct synthesis of some electron-deficient chalcones and heterocyclic chalcones from cinnnamic acid

34 for the enantioselective addition of FNSM to chalcones and the catalysts CN I, CD I, QN I-IV, and QD

35 Chalcones and their derivatives have been shown to have

36 yridones are synthesized in three steps from chalcones and then condense with carbon disulfide to aff

37 4,2',4',6'-Tetrahydroxychalcone (chalcone) and 4,2',4'-trihydroxychalcone (deoxychalcone)

38 iles (arylidenemalononitrile and substituted chalcone) and those calculated from E, N, and sN shows t

39 or hydroxycinnamates, acyl-sugar, naringenin chalcone, and a range of glycoalkaloids.

40 including depletion of rutin and naringenin chalcone, and enhanced levels of anthocyanins and phenyl

41 ons, neutral quinoidal bases, hemiketals and chalcones, and negatively charged phenolates) by means o

42 A series of 31 chalcone- and flavonoid-based derivatives were synthesiz

43 cid derivatives, their ketone analogues, and chalcones; and (b) bis(benzylidene)cycloalkanones, Ar-CH

44 The results show the boronic-chalcones are more toxic to breast cancer cells compared

45 he soybean type I CHI, which uses naringenin chalcone as substrate, is coordinately regulated with ot

46 typical naringenin CHS that synthesizes the chalcone as the main reaction product, and p-coumaryltri

47 Together, our data reveal chalcones as a promising category of compounds that shou

48 to be tolerated at several positions of the chalcone backbone as long as the compounds fell into the

49 This study aims to establish SAR of chalcone-based compounds to NF-kappaB inhibition, to exp

50 The structures of chalcone-based NF-kappaB inhibitors vary significantly t

51 explore the feasibility of developing simple chalcone-based potent NF-kappaB inhibitors, and to evalu

52 ces not only acridone and quinolone but also chalcone, benzophenone, and phloroglucinol from 4-coumar

53 a CAN-catalyzed multicomponent reaction from chalcones, beta-dicarbonyl compounds, and ammonium aceta

54 n most cases and thus demonstrating that the chalcones can be proficiently synthesized in micellar so

55 n rate for the unimolecular rearrangement of chalcone (CHN) into flavanone by seven orders of magnitu

56 c route to derivatives of styrene, stilbene, chalcone, cinnamic acid, various fused carbo- and hetero

57 he first examples of monoterpene-monoterpene-chalcone conjugates in nature, whereas compound 4 was an

58 ve to inhibition by trans-4-iodo, 4'-boranyl-chalcone, consistent with HDM2-catalyzing ubiquitination

59 was an unprecedented monoterpene-substituted chalcone containing a 3,4,5-trioxygenated cyclohexa-2,5-

60 were undertaken with the synthesis of 21 new chalcones containing two allyloxy moieties that resulted

61 Chalcones continue to attract considerable interest due

62 sults indicated that S17 is a leadbrominated chalcone derivate and deserves further investigation for

63 ed study describes the identification of the chalcone derivative 15 on different types of human malig

64 The newly identified chalcone derivative 15 showed a higher therapeutic poten

65 her, these results indicate that the boronic chalcone derivative AM114 induces significant cytotoxic

66 In this study, using a novel chalcone derivative chalcone-24 (Chal-24), we identified

67 oducts, we have designed and synthetized the chalcone-derivative 8 possessing Notch inhibitory activi

68 Chalcone derivatives are shown to possess excellent anti

69 ries of carboxylated, heteroaryl-substituted chalcone derivatives as novel, potent inhibitors of vasc

70 Curcumin and its chalcone derivatives inhibit the growth of human cancer

71 Among the eight chalcone derivatives tested, 3,5-bis-(4-boronic acid-ben

72 y, 2-arylindazoles provide the corresponding chalcone derivatives under similar reaction conditions.

73 A new series of etherification chalcone derivatives were designed and synthesized throu

74 ing and the lipophilic substituted B ring of chalcone derivatives were pharmacophoric elements for an

75 A series of boronic-chalcone derivatives were synthesized and tested for ant

76 -trisubstituted cyclopentenes from enals and chalcone derivatives with high levels of diastereoselect

77 lationship study of a series of 30 synthetic chalcone derivatives with hydroxyl, methoxyl, and haloge

78 An efficient approach to cyclohexenyl chalcones employing highly electron rich 2'-hydroxychalc

79 The indirect anodic oxidation of chalcone epoxides in the presence of electron-rich heter

80 ogeneous electron transfer between Med*+ and chalcone epoxides is facilitated by an electron-rich het

81 potential is less than that of the starting chalcone epoxides.

82 The barley and rice chalcone flavonone isomerase (Cfi) genes were isolated a

83 ollows the typical reaction network of trans-chalcone-flavylium photoswitches.

84 A representative chalcone/flavylium photoswitch was investigated in more

85 study, we have evaluated a series of boronic chalcones for their anticancer activity and mechanisms o

86 Slow rate of chalcone formation and resistance to C-ring fission were

87 catalyze malonyl-CoA decarboxylation without chalcone formation.

88 n we demonstrate that flavokawain B (FKB), a chalcone from kava root, is a potent hepatocellular toxi

89 ) catalyzes formation of the phenylpropanoid chalcone from one p-coumaroyl-CoA and three malonyl-coen

90 cavity resulting in production of naringenin chalcone from p-coumaroyl-CoA.

91 lectron-deficient chalcones and heterocyclic chalcones from cinnnamic acids.

92 ype is characterized by the presence of both chalcone (heretofore not reported in pre-Columbian texti

93 ession, using the compound hesperidin methyl chalcone (HMC).

94 A series of novel hydroxy-coumarin-chalcone hybrid compounds 2a-i has been synthesized by e

95 tive individual stilbene (IC(50) > 100 muM), chalcone (IC(50) = 11.5 muM), or an equimolar mixture of

96 uM), or an equimolar mixture of stilbene and chalcone (IC(50) = 32.5 muM) were less potent than 11.

97 flavanones by selectively binding an ionized chalcone in a conformation conducive to ring closure in

98 ntly outperformed both untreated samples and chalcones in citric acid production, with enhancements o

99 1,4-/1,2-reduction of the resulting sulfonyl chalcones in THF or MeOH/THF at 25 degrees C; and then (

100 We found that this chalcone inhibited both constitutive and interleukin-6-i

101 Potent bis-chalcone inhibitors were identified, the efficiency depe

102 catalyzes the intramolecular cyclization of chalcones into (S)-flavanones with a second-order rate c

103 ically defined intramolecular cyclization of chalcones into biologically active (2S)-flavanones by se

104 trates that efficient cyclization of various chalcones into their respective flavanones requires both

105 s the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones.

106 Chalcone is a privileged structure, demonstrating promis

107 Naringenin chalcone is only detectable in the fruit, while naringen

108 amolecular and stereospecific cyclization of chalcones is a committed step in the production of flavo

109 benzaldehydes with acetophenones, to produce chalcones, is the final loss of hydroxide and formation

110 Xanthohumol (XN), a prenylated chalcone isolated from hop plant, exhibits anti-inflamma

111 mpferol, the isoflavone biochanin A, and the chalcone isoliquiritigenin.

112 o inhibition by flavonoids, particularly the chalcone isoliquiritigenin.

113 isoflavonoid, and anthocyanin biosynthesis, chalcone isomerase (CHI) catalyzes the intramolecular cy

114 Chalcone isomerase (CHI) catalyzes the intramolecular cy

115 In aqueous solution, Medicago savita chalcone isomerase (CHI) enhances the reaction rate for

116 However, the lineage of the enzyme chalcone isomerase (CHI) remained unknown.

117 Chalcone synthase (CHS) and chalcone isomerase (CHI) were overexpressed and purified

118 rid assays indicated that chalcone synthase, chalcone isomerase (CHI), and dihydroflavonol 4-reductas

119 mmonia-lyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI), and dihydroflavonol reductase

120 ies indicating that chalcone synthase (CHS), chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H),

121 Cinnamic acid 4-hydroxylase (C4H), chalcone isomerase (CHI), isoflavone reductase (IFR) and

122 lar locations of chalcone synthase (CHS) and chalcone isomerase (CHI), the first two enzymes of this

123 SlCHI1) of the flavonoid biosynthetic enzyme chalcone isomerase (CHI), which catalyzes the conversion

124 sly distribute to the terrestrial plants and chalcone isomerase (CHI)-catalyzed intramolecular and st

125 FLAVONOID-3' HYDROXYLASE (F3'H) gene, nco in CHALCONE ISOMERASE (CHI).

126 ments from the known flavonoid genes, except chalcone isomerase (chi1), were induced in the CRC-expre

127 Madicago sativa chalcone isomerase (CI) catalyzes the isomerization of c

128 gulates the expression of chalcone synthase, chalcone isomerase and dihydroflavonol reductase genes r

129 intermediate naringenin, the product of the chalcone isomerase enzyme.

130 nt cellular processes, we used wild-type and chalcone isomerase mutant (transparent testa 5, tt5) see

131 d by threefold on introduction of an alfalfa chalcone isomerase transgene.

132 TT5, and TT3 loci encode chalcone synthase, chalcone isomerase, and dihydroflavonol 4-reductase, res

133 increased by expressing both IFS and alfalfa chalcone isomerase, but levels of flavonol conjugates we

134 genes included phenylalanine ammonia lyase, chalcone isomerase, isoflavone reductase, cinnamoyl-CoA

135 t the accumulation of the chalcone synthase, chalcone isomerase, or flavanone-3-hydroxylase proteins.

136 Chalcone isomerase-like (CHIL) protein is a noncatalytic

137 tomato with the Petunia chi-a gene encoding chalcone isomerase.

138 nd including phenylalanine ammonia lyase and chalcone isomerase.

139 Chalcone isomerases (CHIs) have well-established roles i

140 lly characterized five soybean (Glycine max) chalcone isomerases (CHIs), key enzymes in the phenylpro

141 inately expressed with chalcone synthase and chalcone isomerases is seedlings, whereas dihydroflavono

142 We recently described a chalcone-like compound, 3-(2-methyl-1H-indol-3-yl)-1-(4-

143 Cathepsin B digests Val-Ala-02 and Val-Ala-Chalcone linkers efficiently, enabling cleavage of oligo

144 g discovery program, we isolated two similar chalcones, medicagenin (II) and munchiwarin (III), from

145 The intermediate 3 contains a chalcone motif.

146 roducing mutant (nco) accumulated naringenin chalcone, not previously reported in lettuce, to 1% dry

147 There was also induction of several chalcone O-methyltransferases involved in the synthesis

148 Isoliquiritigenin, the precursor chalcone of liquiritigenin, demonstrated significant est

149 we investigated in detail the effect of this chalcone on NF-kappaB activity.

150 oieties such as alkenes (stilbenes), enones (chalcones), or ethers was selected for the study.

151 The yellow-green naringenin chalcone overproducing mutant (nco) accumulated naringen

152 The kinetics of chalcone oxide hydrolysis show that mutation of Tyr(465)

153 lding of the tetraketide intermediate to the chalcone (PKS3) and which are in general essential for C

154 hydrochalcones and their dihydrochalcone and chalcone precursors was synthesized and tested as SGLT1/

155 erize 16 point mutants of these residues for chalcone production, malonyl-CoA decarboxylation, and th

156 ural products and their analogues, including chalcones, pyrazoles, chromones, coumarins, xanthines, i

157 ng of genes for isoflavone synthase (IFS) or chalcone reductase (CHR) was achieved in soybean roots t

158 nia-lyase (PAL), chalcone synthase (CHS) and chalcone reductase (CHR) were most rapidly activated, wi

159 Interestingly, chalcone reductase adopts the three-dimensional structur

160 e the three-dimensional structure of alfalfa chalcone reductase bound to the NADP+ cofactor and propo

161 nhanced expressions of chalcone synthase and chalcone reductase genes, mainly in the exposed and imme

162 Silencing of chalcone reductase led to very low levels of daidzein an

163 In addition, the chalcone reductase structure represents the first protei

164 plex, the quality of the refined NADP+-bound chalcone reductase structure serves as a template for co

165 Therefore, the chalcone reductase structure serves as a template for th

166 cone reductase; however, the identity of the chalcone reductase substrate out of the possible substra

167 arity to other aldo-keto reductases, such as chalcone reductase, an enzyme of flavonoid biosynthesis,

168 Introduction of a third gene, chalcone reductase, provided the ability to synthesize a

169 e formation depends on chalcone synthase and chalcone reductase; however, the identity of the chalcon

170 Novel stilbene-chalcone (S-C) hybrids were synthesized via a sequential

171 n relied on the A ring hydroxyl group of the chalcone scaffold and cLogP increase in the sulfonamide

172 activity relationships were afforded for the chalcone scaffold.

173 First a model was generated for the chalcone series (19 compounds, 71 conformations), then f

174 pounds, including six homoisoflavonoids, one chalcone, six amides, one lignan, one fatty acid derivat

175 ven to the extent that an enzyme of the same chalcone/stilbene synthase family used to produce phytoa

176 e presence of a glycosyl moiety bound to the chalcone structure dramatically decreases the antimicrob

177 eported are based on the benzalacetophenone (chalcone) structure, again coupling the boronic acid and

178 ramatically lowers the triplet energy of the chalcone substrate.

179 d step of isoflavonoid biosynthesis, various chalcone substrates added to the culture media were conv

180 ile the type II CHIs, which use a variety of chalcone substrates, are coordinately regulated with an

181 ne after hormone induction, whereas only the chalcone synthase (c2) and flavanone/dihydroflavonol red

182 it ripening is accompanied by an increase in CHALCONE SYNTHASE (CHS) activity and flavonoid biosynthe

183 Chalcone synthase (CHS) and chalcone isomerase (CHI) wer

184 The cellular and subcellular locations of chalcone synthase (CHS) and chalcone isomerase (CHI), th

185 ncoding L-phenylalanine ammonia-lyase (PAL), chalcone synthase (CHS) and chalcone reductase (CHR) wer

186 Chalcone synthase (CHS) belongs to the family of type II

187 Chalcone synthase (CHS) catalyzes formation of the pheny

188 Chalcone synthase (CHS) catalyzes the first step of flav

189 ctures and floral pigmentation patterns from chalcone synthase (chs) co-suppression among 47 Petunia

190 le example of an extended gene family is the chalcone synthase (CHS) family of genes, and particular

191 Infection with TRV containing a chalcone synthase (CHS) fragment resulted in silencing o

192 identified in previous work as essential for chalcone synthase (CHS) function.

193 trefoil) were transformed with an antisense chalcone synthase (CHS) gene construct made using a stre

194 Three of the chalcone synthase (CHS) gene family members are arranged

195 nerated, containing additional copies of the chalcone synthase (CHS) gene.

196 s of the I locus in Glycine max silence nine chalcone synthase (CHS) genes to inhibit function of the

197 n earlier study we reported HDG silencing of chalcone synthase (CHS) in Arabidopsis.

198 Chalcone synthase (CHS) is a ubiquitous plant PKS and th

199 coding the key flavonoid biosynthesis enzyme chalcone synthase (CHS) is regulated by several environm

200 Five new alleles of the Arabidopsis chalcone synthase (CHS) locus, tt4, have been characteri

201 Expression of chalcone synthase (CHS) mRNA was shown to be constitutiv

202 ng small interfering RNAs (siRNAs) targeting chalcone synthase (CHS) mRNAs.

203 Measurements of rbcS and chalcone synthase (CHS) transcript levels in the protopl

204 gmentation patterns were scored in 185 sense Chalcone synthase (Chs) transgenotes and 85 antisense Ch

205 Crystallographic and functional studies of chalcone synthase (CHS), a plant-specific PKS, indicate

206 Chalcone synthase (CHS), a type III plant polyketide syn

207 that simultaneous RNAi silencing of HCT and chalcone synthase (CHS), an enzyme essential for flavono

208 cS), the gene family that encodes the enzyme chalcone synthase (Chs), and the gene family that encode

209 ties with C. microcarpa ACS, Medicago sativa chalcone synthase (CHS), and the previously reported Aeg

210 examining phenylalanine ammonia-lyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI), and d

211 istent with previous studies indicating that chalcone synthase (CHS), chalcone isomerase (CHI), flava

212 Among them, three genes, namely chalcone synthase (CHS), glutathione S-transferase (GST)

213 re well illustrated by the genes that encode chalcone synthase (CHS), the first committed step in fla

214 Expression of chalcone synthase (CHS), the first enzyme in the flavono

215 ng as a metabolite binder and a rectifier of chalcone synthase (CHS).

216 operties of three recombinant Fragaria vesca chalcone synthase (FvCHS) proteins.

217 ], 4-coumarate coenzyme A:ligase [4-CL], and chalcone synthase [CHS]) are conserved in the t-CAH prom

218 petunia plants can result in degradation of chalcone synthase A RNAs and loss of chalcone synthase,

219 The introduction of chalcone synthase A transgenes into petunia plants can r

220 A lack of chalcone synthase activity has a pleiotropic effect in m

221 psis F3H gene is coordinately expressed with chalcone synthase and chalcone isomerases is seedlings,

222 ype, lactofen caused enhanced expressions of chalcone synthase and chalcone reductase genes, mainly i

223 Deoxychalcone formation depends on chalcone synthase and chalcone reductase; however, the i

224 nous biosynthetic genes (c2 and a1, encoding chalcone synthase and flavanone/dihydroflavonol reductas

225 arent testa4-2, which has a null mutation in CHALCONE SYNTHASE and therefore synthesizes no flavonol

226 Chalcone synthase catalyzes the initial step of that bra

227 adjacent H-box in the proximal region of the chalcone synthase chs15 promoter.

228 (inhibitor diffuse) mutant, defective in the CHALCONE SYNTHASE Colorless2 (C2) gene.

229 the introduction of a heterologous antisense chalcone synthase construct into L. corniculatus resulte

230 ile element dynamics in seven alleles of the chalcone synthase D locus (CHS-D) of the common morning

231 tion and CHLOROPHYLL a/b BINDING PROTEIN3 or CHALCONE SYNTHASE expression under red light.

232 PqsD is structurally similar to the FabH and chalcone synthase families of fatty acid and polyketide

233 P-glucose pyrophosphorylase gene (APL3), and chalcone synthase gene (CHS), whereas the mybs2 mutant e

234 In this study, we demonstrate that chalcone synthase gene (chsA) expression is developmenta

235 Down-regulation of the CHALCONE SYNTHASE gene and concomitant induction of FaPR

236 vergence times based on sequence data of the chalcone synthase gene are congruent with comparative pa

237 e 3' splice acceptor site in the Arabidopsis chalcone synthase gene completely disrupts synthesis of

238 ontrolled post-transcriptional regulation of chalcone synthase gene expression by influencing the sur

239 Ppr also regulates chalcone synthase gene expression in response to blue li

240 C2-Idf is a stable dominant mutation of the chalcone synthase gene, c2, which encodes the first dedi

241 ctly repeated and inverted clusters of three chalcone synthase genes (CHS1, CHS3, and CHS4).

242 -mediated induction of flavonoids and blocks chalcone synthase mRNA and protein induction.

243 al roots under the Pi- Suc- condition in the chalcone synthase mutant (tt4-2) indicated a potential r

244 the H-box (CCTACC) element in the bean CHS15 chalcone synthase promoter was purified, and internal pe

245 d during the multistep reaction catalyzed by chalcone synthase remains experimentally elusive.

246 ved from an evolutionarily related member of chalcone synthase superfamily by mere substitution of tw

247 e pathway branch for flavonoid biosynthesis (chalcone synthase), a key enzyme in medicarpin biosynthe

248 n (a commonly reported derailment product of chalcone synthase), while similar in vitro analyses usin

249 sion of a reporter driven by the promoter of CHALCONE SYNTHASE, a gene encoding a flavonol biosynthet

250 de anther-specific proteins with homology to chalcone synthase, a key flavonoid biosynthesis enzyme.

251 Chalcone synthase, a key regulatory enzyme in the flavon

252 tion of chalcone synthase A RNAs and loss of chalcone synthase, a process called cosuppression or pos

253 he heterologous phenylalanine ammonia lyase, chalcone synthase, and DRR206 promoter-beta-glucuronidas

254 l pea PR genes: phenylalanine ammonia lyase, chalcone synthase, and DRR206.

255 pression levels (most notably those of NDL1, CHALCONE SYNTHASE, and MYB DOMAIN PROTEIN44) in plants c

256 Two-hybrid assays indicated that chalcone synthase, chalcone isomerase (CHI), and dihydro

257 ain protein that regulates the expression of chalcone synthase, chalcone isomerase and dihydroflavono

258 The TT4, TT5, and TT3 loci encode chalcone synthase, chalcone isomerase, and dihydroflavon

259 also did not inhibit the accumulation of the chalcone synthase, chalcone isomerase, or flavanone-3-hy

260 ys further demonstrated interactions between chalcone synthase, CHI, and flavonol 3-hydroxylase in ly

261 Adding tt4, which disables chalcone synthase, had little effect, but adding the tgd

262 nd Glycine max chalcone synthase1 (Gmachs1), chalcone synthase, involved in phytoalexin production.

263 ch have a null mutation in the gene encoding chalcone synthase, the first enzyme in flavonoid synthes

264 Silencing of chalcone synthase, the key entry-point enzyme for flavon

265 omatized coumaryl-trione intermediate of the chalcone synthase-catalyzed cyclization of the fully ext

266 son among related plant species shows that a chalcone synthase-like (CHS-L) gene family has lineage-s

267 N), which is biosynthesized in bacteria by a chalcone synthase-like (CS-like) type III polyketide syn

268 s, we disrupted a mas-like gene, msl7, and a chalcone synthase-like gene, pks10, with phage-mediated

269 oester, which then serves as a substrate for chalcone synthase.

270 ion of CHLOROPHYLL A/B BINDING PROTEIN 3 and CHALCONE SYNTHASE.

271 the first enzyme in flavonoid biosynthesis, chalcone synthase.

272 oid pathway, phenylalanine ammonia-lyase and chalcone synthase.

273 nvolved in pathogen defense, and Glycine max chalcone synthase1 (Gmachs1), chalcone synthase, involve

274 stilbene backbone, seem to have evolved from chalcone synthases (CHSs) several times independently in

275 Anthocyanin biosynthesis structural proteins chalcone synthases and flavonone 3-hydroxylase and diffe

276 s related to beta-ketoacyl-CoA synthases and chalcone synthases.

277 ve SAR analysis of saturated and unsaturated chalcone synthetic intermediates, led to the identificat

278 Starting from a simple chalcone template, structure-activity relationship (SAR)

279 under Claisen-Schmidt conditions afforded a chalcone that was deprotected and cyclized in the presen

280 We here synthesized symmetric bis-chalcones that were differently substituted and screened

281 enzyme A thioesters to synthesize naringenin chalcone through a polyketidic intermediate.

282 somerase (CI) catalyzes the isomerization of chalcone to flavanone, whereas E. coli chorismate mutase

283 which catalyzes the conversion of naringenin chalcone to naringenin and is strictly required for flav

284 vascular plants, CHI-catalysed conversion of chalcones to chiral (S)-flavanones is a committed step i

285 l of benzils in a Stetter-like reaction with chalcones to give 2-benzoyl-1,4-diones (double aroylatio

286 alyst efficiently activates the o-homoformyl chalcones to provide the chiral isochromenes in moderate

287 silylation, and deoxygenative cyclization of chalcones to provide the cyclopropane products.

288 hiles), and the reactions can lead to either chalcone-type products or indanone products.

289 d-forming reactions of lactone enolates with chalcones under phase transfer conditions in toluene.

290 o switchable species (40 M(-1) for the trans-chalcone versus 3.5 x 10(4) M(-1) for the flavylium cati

291 In this work, 100 chalcones were designed, synthesized, and investigated f

292 Chalcones were found to undergo sulfurative dimerization

293 Chalcones were identified as the major heat degradation

294 amates, crotonates, coumarins, sulfones, and chalcones were successfully functionalized.

295 A library of 88 chalcones were synthesized and evaluated for their in vi

296 Three series of chalcones were synthesized in one to three steps with th

297 phenone, respectively, and formed naringenin chalcone when 4-coumaroyl-CoA was used as starter molecu

298 ids are accumulated together with naringenin chalcone, whereas CmKFB expression diverts the biochemic

299 Treatment of trans-chalcone with dibenzo-7-phosphanorbornadiene EtOPA (A =

300 Chalcones with extended conjugation and 4-chromanone-bas

301 the discovery of 2',4'-diallyloxy-6'-methoxy chalcones with improved selectivity against this parasit