ライフサイエンスコーパス: challenge

1 from stroke mimics (SMs) poses a diagnostic challenge.

2 carriers - which aim to address the delivery challenge.

3 ges through particular communities remains a challenge.

4 protective efficacy against M. tuberculosis challenge.

5 molecules in artificial cells has remained a challenge.

6 s a significant experimental and theoretical challenge.

7 e a day before sensitization or a day before challenge.

8 ducibility of biomedical research is a major challenge.

9 onformational ensemble remains a significant challenge.

10 ould have a leading role in this unprecedent challenge.

11 in these association regions remains a major challenge.

12 tive protection against the second impending challenge.

13 e input in heart tissues remains a technical challenge.

14 acle of asymmetric synthesis and an unsolved challenge.

15 or of energy metabolism, in response to ZIKV challenge.

16 brication from nano- to macroscale remains a challenge.

17 ion to a growing global population will be a challenge.

18 such representative features remains a grand challenge.

19 e describe a novel framework to address this challenge.

20 a data-driven response to this public health challenge.

21 atification to guide interventions remains a challenge.

22 All assessments showed changes with gluten challenge.

23 nsing at the cellular level is still an open challenge.

24 m processing of used nuclear fuel is a major challenge.

25 lature represents an unresolved experimental challenge.

26 for handling the so-called missingness have challenges.

27 ina, a new version of Vina, to address these challenges.

28 ing cancer, but they also pose many delivery challenges.

29 c labeling of cysteines, each with attendant challenges.

30 ns many exciting avenues but also create new challenges.

31 ying targeting, toxicity, and immunogenicity challenges.

32 mune-related adverse events remain two major challenges.

33 d to mitigate some of the most long-standing challenges.

34 during acquisition and pre-processing can be challenging.

35 mics of NAD in living plant tissues has been challenging.

36 pressure fields directly from the images is challenging.

37 and sizes in the range of 10-100 nm remains challenging.

38 forming imaging-guided lymph node surgery is challenging.

39 ely on social learning has proved remarkably challenging.

40 ak interactions at atomic resolution remains challenging.

41 where clinical diagnosis is often also more challenging.

42 , the characterization of which is, however, challenging.

43 ity, and quantitative impact of SVs has been challenging.

44 d Rmaps, make assembly and alignment of them challenging.

45 atomistic simulations remain computationally challenging.

46 opulations without side effects has remained challenging.

47 mplex quantum materials has proven extremely challenging.

48 tions between multiple dopants or defects is challenging(13,14).

49 ssues, the PhysioNet/Computing in Cardiology Challenge 2019 facilitated the development of automated,

50 f IL-17A in vaccinated C57BL/6 mice prior to challenge abrogated the protective efficacy of GCP-rCpa1

51 iving with Sjogren syndrome made every day a challenge (adjusted odds ratio [OR] 3.81, 95% confidence

52 l methods in cryo-EM and identify persisting challenges and bottlenecks that will require further met

53 ess of women in our field, we review ongoing challenges and discuss potential approaches to help adva

54 ovel formulations will address drug delivery challenges and have great potential to improve the effic

55 er descriptions of the multivariate physical challenges and interactions among challenges in high-ele

56 systems that can address resource management challenges and opportunities at three scales of resoluti

57 ted the adoption of telemedicine, presenting challenges and opportunities for clinicians trying to ma

58 We conclude by highlighting the challenges and opportunities in the application of micro

59 These advances have also revealed new challenges and opportunities, and expertise from multipl

60 tal fingerprint with multiple pairs of input challenges and output responses.

61 The current challenges and possible solutions for improving these no

62 Finally, we propose some conceptual challenges and provide our perspectives on how to bridge

63 In an era of large-scale science-related challenges and rapid advancements in groundbreaking scie

64 inks between the statistics of environmental challenges and the ants' collective navigation abilities

65 le O-glycans make the IgA1 glycomic analysis challenging and better approaches are needed.

66 rent, making endoscopy sometimes technically challenging and necessitating clear and frequent communi

67 f tasks: breath-hold challenge, cold-pressor challenge, and heartbeat perception during and outside o

68 als in the 100-mug dose group by day 2 after challenge, and limited inflammation or detectable viral

69 red for quantum error correction, presents a challenge, and this goal remains the focus of intense re

70 , prevention and timely management, existing challenges, and directions to improve research on the fi

71 and immunology and highlights the potential, challenges, and implications of natural language process

72 lection within such communities is extremely challenging, and it is thus unclear how eco-evolutionary

73 The challenging annulations of two different alkynes in a re

74 downstream bioprocess monitoring and similar challenging applications which can not be readily met by

75 tential for each analytical strategy and its challenges are discussed as well as improvements needed

76 nergy densities, yet this architecture faces challenges arising from interfacial issues between the e

77 ous antigenic epitopes remains a substantial challenge, as exemplified by the case of lipid transfer

78 ICU clinician perspectives on challenging aspects of care in managing coronavirus dise

79 t provides a comprehensive review of aspirin challenges, aspirin desensitizations, and maintenance as

80 There are many pharmacokinetic challenges associated with administering protein therape

81 Pancreatic cancer (PC) remains a therapeutic challenge because of its intrinsic and extrinsic chemore

82 However, this conclusion was recently challenged because residual uncorrected stratification f

83 r, targeting skeletal myosin is particularly challenging because of its similarity to the cardiac iso

84 However, genome sequencing of specimens is challenging because of low bacterial and high human DNA

85 cts of these degradation products has proven challenging because of the complexity, transience, and l

86 hanistic prediction of plant gas exchange is challenging because of the diversity of biological compo

87 However, testing this is challenging because P varies within landscapes as a func

88 synthesize HMOs, however, their analysis is challenging, both in resolution and speed.

89 of CCHFV infection reliably succumb to virus challenge but vary in their ability to reflect signs of

90 ated human CD8(+) T cells, which represent a challenging but valuable model to gain insight into CTL

91 Achieving long-range uniformity remains a challenge, but this process could provide a route to syn

92 We previously addressed this challenge by developing time-shifted mean-segmented Q (t

93 In pigs challenged by gavage with HEWP, clinical signs were note

94 c DRG neurons and migration of Schwann cells challenged by high glucose.

95 electron carriers, the mobility of which is challenged by macromolecular crowding.

96 Rapid phenotypic AST for Ng is challenged by the pathogen's slow doubling time and the

97 erized by an enhanced infection risk will be challenged by the virus.

98 te that the use of F(+) oxidants permits the challenging C(sp(3))-OC(sp(3)) bond formation at a high-

99 ies of meetings were convened to address the challenges caused by the COVID-19 pandemic, review optio

100 cessing across a panel of tasks: breath-hold challenge, cold-pressor challenge, and heartbeat percept

101 We developed a new approach to address this challenge, combining long-range PCR and nanopore sequenc

102 ore the utility of inducible RNA tagging and challenge current models of telomerase maturation.

103 cal knowledge to be applied appropriately at challenging decision points during case management.

104 perty control, is often still a considerable challenge despite their advantageous optical responses a

105 However, eradication of HIV is a major challenge due to cellular and anatomical viral reservoir

106 s in organocatalyzed reactions is an ongoing challenge due to subtle, noncovalent interactions that d

107 ance proteins from blood remains an unsolved challenge due to the extraordinary dynamic range of the

108 on adjacent carbon atoms is an extraordinary challenge due to the lack of electronic or steric bias b

109 ng the resulting radiomic datasets remains a challenge due to the lack of specific tools for doing so

110 gastrointestinal (GI) tract imaging remains challenging due to fluorescence quenching in the digesti

111 udies with syngeneic tumour models which are challenging due to high variability both within and betw

112 However, targeting survivin has been challenging due to its "undruggable" nature.

113 own lithographic approaches has proven to be challenging due to poor structural control at the atomic

114 o understanding the disease itself, which is challenging due to the altered cardiac physiology in the

115 al-based delafossites, which are known to be challenging due to the difficulty in initial nucleation.

116 A particular challenge, especially for membrane proteins, is preservi

117 on, metal oxides, etc.) remains a formidable challenge, especially under high-temperature conditions.

118 ease (SR-aGVHD) poses one of the most vexing challenges faced by providers who care for patients afte

119 Here, we define ten key challenges facing cancer immunotherapy, which range from

120 ever, the vast diversity of HIV-1 is a major challenge for both active and passive immunization.

121 r exceptional adaptability and poses a major challenge for developing effective strategies to reduce

122 al sparsity of these measurements presents a challenge for estimating representative long-term concen

123 A critical challenge for GWASs has been the dependence on individua

124 y and function of energy materials remains a challenge for instrumentation science.

125 ssant treatment response has been a clinical challenge for major depressive disorder (MDD).

126 n organic chemistry and stands as an eminent challenge for mechanistic elucidation.

127 e interferometry has remained an outstanding challenge for natural polypeptides, building blocks of l

128 limits its therapeutic efficacy and poses a challenge for potential patient compliance.

129 ts of m(6)A on viral and host RNAs remains a challenge for the field.

130 association studies, and we discuss current challenges for biological understanding and future requi

131 sis produce major conceptual and operational challenges for empiricists.

132 xisting tools, and discuss opportunities and challenges for integrating a rapid diet screener tool in

133 ape, bringing with them new requirements and challenges for next-generation cancer nanomedicines.

134 N(2) molecule pose thermodynamic and kinetic challenges for promoting reactivity.

135 a cells and memory B cells and highlight the challenges for successful vaccine development in each ph

136 ase 2019 pandemic has resulted in additional challenges for systems designed to perform expeditious p

137 , raising new theoretical and methodological challenges for the field.

138 Strategies are presented that address key challenges for the preparation of coordination cages tha

139 Together with discussion on technical challenges for this REBCO shim coil concept, we demonstr

140 re of proteins is now established, it can be challenging for beta-barrel proteins, which are importan

141 antitative measurements from these images is challenging for researchers who are not image analysis s

142 Sometimes, however, it can also be extremely challenging for various intrinsic reasons (e.g. low targ

143 sociated emissions, has however been seen as challenging from a global perspective.

144 ry pathways are still sparse and represent a challenging frontier for further experimental exploratio

145 During a dietary challenge, FtMT-Adip mice are leaner but exhibit glucose

146 To address this challenge, here we present an enzymatic method to clean

147 Its implementation faces substantial challenges, however; for example, the tremendous number

148 A challenge in biology is to associate molecular differenc

149 ical probes or drug candidates is an ongoing challenge in biomedical research.

150 A major challenge in cell and developmental biology is the autom

151 An ongoing challenge in chemical research is to design catalysts th

152 y describe TB resistance patterns is a major challenge in ensuring that all persons diagnosed with dr

153 ation to phenotypical traits remains a major challenge in evolutionary genetics.

154 The key challenge in generating antibody-based inhibitors is the

155 A major challenge in neurobiology in the 21st century is to unde

156 pica (L. tropica) represents a public health challenge in several resource poor settings.

157 Actuation remains a significant challenge in soft robotics.

158 The main challenge in these cases is that, to compete with the Nu

159 esistance to hormone therapy remains a major challenge in treating advanced prostate cancer.

160 n with ozone, however, was nontrivial due to challenges in assigning reactive positions in the probe

161 ring in medicine to address the multitude of challenges in cancer drug resistance.

162 es of complex genomes is one of the ultimate challenges in genomics.

163 e physical challenges and interactions among challenges in high-elevation streams, which include low

164 First, we discuss enduring challenges in identifying and predicting risk for pediat

165 ne-related adverse events, there are several challenges in interpreting the results of this investiga

166 ancer progression is limited, in part due to challenges in maintaining F. nucleatum viability under s

167 With these challenges in mind, we developed RIPTiDe (Reaction Inclu

168 Analysis of major challenges in the field along with exciting opportunitie

169 Here, we review progress and challenges in the use of AD mouse models, highlight emer

170 functional language, more social motivation challenges in those with ASD, larger head circumference,

171 ers are, therefore, faced with a plethora of challenges including acute and critical care management,

172 ition to create materials relevant to energy challenges including photoconductors and supercapacitors

173 n some regions facing greater implementation challenges, including the nations of Central Africa, whe

174 Drug delivery to the brain always remains a challenging issue for scientists due to the complex stru

175 Inflammatory challenge led to robust eGFP-L10a upregulation in kidney

176 These measurement challenges make it difficult to assess the validity of c

177 ambient electrochemical NRR are significant challenges, making a simultaneous high NH(3) formation r

178 people with OA, but despite the scale of the challenge many individuals are still not offered the saf

179 iter, rate, yield (TRY), and scalability are challenging metrics to achieve due to trade-offs between

180 ccination-Mycobacterium tuberculosis (M.tb.) challenge model to test the protective efficacy of BCG-d

181 The direct-instillation nasal allergen challenge (NAC) and the environmental exposure chamber (

182 g the protective effect of MN-siCas-3 in the challenging NHP model, this study proposes a novel strat

183 nd thus a novel route to tackling the global challenge of AMR.

184 Live virus challenge of animals given SARS or MERS vaccines resulte

185 s were small fragments, which highlights the challenge of assembling viral genomes from short-read me

186 Today, the planet again faces the challenge of how to provide people with clean water.

187 A major challenge of intracellular parasite research is collecti

188 nsic death signals and stressors adds to the challenge of isolating and interpreting the roles of pro

189 n hampered by technical difficulties and the challenge of obtaining fresh tissues.METHODSThis observa

190 one-class classifier to use followed by the challenge of optimizing the chosen classifier (identifyi

191 has been successfully adapted to address the challenge of resolving a cascade of fast and co-occurrin

192 ventional biochemical assays that retain the challenges of being time-consuming, poorly sensitive and

193 The formidable challenges of controlling site-selectivity, enantioselec

194 However, solutions to the scientific challenges of developing antiicing surfaces remain elusi

195 years, an associate professor discusses the challenges of faculty life.

196 overall survival (OS), which highlighted the challenges of identifying patients that derive an OS ben

197 rescent proteins remain elusive owing to the challenges of monitoring chromophore structural dynamics

198 ificity is not known because of the inherent challenges of predicting structural features of integral

199 ew SARS-CoV-2 coronavirus has imposed severe challenges on laboratories in their effort to achieve su

200 The current COVID-19 pandemic challenges oncologists to profoundly re-organize oncolog

201 ry approaches, which can make implementation challenging or are variable across different specialties

202 icularly those for which thermoregulation is challenging or ecologically costly.

203 biological phenomena that would be otherwise challenging or impossible to perform in a traditional li

204 This challenges our understanding of organismal functioning,

205 typical teratoid rhabdoid tumors (ATRTs) are challenging pediatric brain cancers that are predominant

206 Cancer metastasis poses a challenging problem both clinically and scientifically,

207 Potassium (K) metal anodes suffer from a challenging problem of dendrite growth.

208 for by environmental heterogeneity and poses challenging questions for understanding the speciation p

209 The role of hapten-carrier adducts in re-challenge reactions leading to mast cell degranulation a

210 ous study identified a significant practical challenge regarding the co-alignment of the magnetic and

211 Although challenges remain, we propose that phase 0 approaches be

212 have been developed in the last century, the challenge remains to identify guidelines that allow fine

213 Solving the V2F challenge requires us to identify causative genetic vari

214 The thermal challenge response (DeltaSBF/DeltaT) was calculated usin

215 ation of potential migrants from plastics in challenging samples such as honey.

216 of anticipatory responses where the initial challenge simultaneously activates pre-emptive protectio

217 Improving this practice is challenging since many clinicians did not train where CM

218 ive folds or designable structures remains a challenge, since few existing metrics capture high-level

219 utpatient ultra-widefield FA (UWFA) and more challenging situations in patients with developmental de

220 However, a number of technical challenges still exist, such as interferences from endog

221 xercise hemodynamic or confrontational fluid challenge studies may also aid decision-making for patie

222 Catenated cages represent chemistry's challenging synthetic targets because a three-dimensiona

223 ation for integral membrane proteins (IMPs), challenging targets for structural determination.

224 This challenging task requires care, especially in terms of s

225 s upon single point mutations in silico is a challenge that has implications for understanding diseas

226 ify outstanding questions and methodological challenges that need to be addressed to advance and soli

227 nd failures of this technology thus far, the challenges that this technology still has to overcome be

228 nce to Cry1 and Cry2 proteins in H. zea will challenge the long-term efficacy of Vip3Aa technology.

229 These results challenge the prevailing model of OSN modulation and hig

230 Experimental developments continue to challenge the theoretical description of molecular inter

231 These results challenge the well established notion of the P3b as a ne

232 rom human newborns and non-human animals has challenged the primary role assigned to culture, in dete

233 However, the chemical stability of DNA challenges the complete erasure of information encoded i

234 need for countermeasures during this crisis challenges the current paradigm of traditional drug disc

235 This challenges the paradigm that extended opioids are needed

236 This challenges the prevailing view and suggests that STING c

237 This challenges the view that CO(2) fertilization is the domi

238 on of individual replisome subunits, thereby challenging the notion that lagging-strand DNA polymeras

239 ent theoretical and comparative studies have challenged this view.

240 roximately 2.04-1.95 million years ago, that challenges this view.

241 Challenging this view, emerging research suggests that o

242 ance against pulmonary Aspergillus fumigatus challenge through the regulation of antifungal leukocyte

243 mber and diversity of sequenced species, the challenge to characterize genes with functional informat

244 le tertiary alkylamines provides a continual challenge to chemical synthesis.

245 ocognitive phenotypes continues to present a challenge to clinical geneticists and diagnostic laborat

246 resents a considerable degree of mechanistic challenge to control the mode of substrate activation as

247 Perhaps the greatest challenge to expanded use of MPAs is the perceived trade

248 me and complexity of genomic data presents a challenge to interpreting enhancer function in normal an

249 prevalence of type 2 diabetes poses a major challenge to societies worldwide.

250 We present the method as a challenge to the community to determine its security.

251 ty of purified GSLs represents a significant challenge to the discovery and characterization of biolo

252 With these challenges to be addressed, this article aims to review

253 Finally, we review challenges to conducting experimental camera trap studie

254 wide, but methodological differences present challenges to large-scale analysis across datasets.

255 ern United States, and represent the primary challenges to marten conservation at the southern periph

256 o calculations, square roots are the gravest challenges to overcome.

257 Challenges to the prevention of severe disease after vir

258 ber of conceptual, practical, and analytical challenges to this line of research and used a preregist

259 rs, highlighting current trends and possible challenges to this rapidly developing area, with a speci

260 Although this complexity poses formidable challenges to understanding the underlying molecular bas

261 partial/leaky splicing defects are the most challenging to classify because the minimal level of ful

262 However, it is always challenging to design platinum complexes suitable for su

263 structures regulating organelle dynamics are challenging to detect with fluorescence microscopy, maki

264 m relative data, but more subtle effects are challenging to identify.

265 It has been challenging to illuminate the features of this synaptic

266 n approaches use complex geometries that are challenging to implement.

267 en locus is coordinated has been technically challenging to investigate.

268 n or medication to treat delirium, making it challenging to manage.

269 es; however, these reproductive barriers are challenging to measure within natural populations.

270 complexity of coral-reef ecosystems makes it challenging to predict their dynamics and resilience und

271 However, it is still very challenging to prepare amorphous noble-metal nanomateria

272 It is challenging to preserve such oligomers in the gas phase

273 n development and evolution, the LPM remains challenging to study and to delineate, owing to its line

274 te lymphoblastic leukemia (ALL) has remained challenging to treat in children, with survival rates la

275 To address the challenges unique to this age group, novel strategies to

276 We also show how more challenging variants of rubazonic acid are efficiently p

277 nforced T-maze alternation task, then a more challenging version that nullifies intramaze cues.

278 nd homologous or closely related vaccine and challenge viruses gave the best prediction of protection

279 s play a key role in action selection during challenging visuomotor behaviors and may possibly serve

280 , using visual crowding as a well-controlled challenge, we previously showed that no classic model of

281 onavirus 2 (SARS-CoV-2) pandemic is a global challenge, which the scientific community has tackled by

282 d Treg cells could be recalled upon allergen challenge, which was associated with suppression of lung

283 gronomic practices to address sustainability challenges while increasing food production.

284 One key challenge with 2D semiconductors is to avoid the formati

285 nza A virus MEM H3N2, followed by intranasal challenge with 5 x 10(7) CFU of NTHi R2866 Spec(r) Mice

286 ce chronically infected with CL13 succumb to challenge with ectromelia virus (ECTV; the agent of mous

287 injury remains a scientific and therapeutic challenge with great cost to individuals and society.

288 which provide far greater resistance against challenge with nontyphoidal serovar Salmonella Enteritid

289 p53DeltaIEC mice (Trp53DeltaIECAktE17K) upon challenge with the carcinogen azoxymethane.

290 Infection challenge with the common coccidian parasites Toxoplasma

291 with OURT88/3 or BeninDeltaMGF followed by a challenge with the virulent Benin 97/1 isolate at day 13

292 Prnp180Q/196Q mice challenged with 2 subfibrillar, non-plaque-forming prion

293 ir enzymatic activities in mice intranasally challenged with a wild-type B anthracis strain or with a

294 -type and CD8-deficient (CD8(-/-)) mice were challenged with allergen.

295 Unexpectedly, bacterial burden in prostates challenged with either UPEC or E. faecalis was equal or

296 d antimicrobial peptides when the flies were challenged with Gram-positive bacteria Micrococcus luteu

297 n's disease (PD) as a single entity has been challenged with the identification of several clinical s

298 es were taken 24 hours after the 1st and 5th challenges with diluent and with allergen.

299 raud, our results also highlight the current challenges with production, trade, and mislabeling data,

300 Clinical microbiology laboratories face challenges with workload and understaffing that other cl