ライフサイエンスコーパス: change in

1 Metabolic flexibility was defined as the change in 24-h RQ from EBL during fasting and standard o

2 e, psychotomimetic symptoms, and gamma power changes in 34 individuals (ages 18-65) with treatment-re

3 olecules in vivo, as well as to evaluate the change in (64)Cu-ATSM signal after redox-active drug tre

4 ailing view of AD pathogenesis has been that changes in Abeta precipitate the disease process and ini

5 ely associated to CRP and IL (interleukin)-1 changes in acute infection patients.

6 We further determined associations with change in ADHD symptoms.

7 e the reinforcement-learning mechanisms that change in adolescence and into adulthood.

8 r discuss the neural mechanisms that support changes in aggression based on the animal's internal sta

9 We discovered additional changes in aging, as glandular-like epithelial invaginat

10 BVOCs and the trends of climate and land-use changes in Amazonia is then constructed.

11 uency were perceptually distinguishable from changes in amplitude-seemingly giving rise to a change i

12 P-tau217 did not change in amyloid-beta-negative participants, or in pati

13 ts (Lp(r) ), we examined how drought-induced changes in anatomy and hydraulic properties of contrasti

14 ression patterns of regulatory genes causing changes in anisotropic cell expansion and division patte

15 Patients who were untreated showed no change in any FDG PET or cardiac MRI parameter.

16 egree of AI and AS did not seem to influence change in aortic dimensions.

17 stance accounted for the majority of dynamic changes in architecture.

18 The proposed imaging system can sense the changes in areas near to the skin-like sensors by measur

19 complex with ARL6(GTP), and we describe the changes in BBSome conformation induced by ARL6(GTP) bind

20 Such changes can lead to profound changes in behavior, but little is known about the preci

21 y dopamine and noradrenaline likely indicate changes in behavioral control that underlie adaptations

22 of nervous system function, and fundamental changes in behaviors such as learning, memory, and socia

23 The primary outcome measure was change in best corrected visual acuity (BCVA) over time.

24 that the CCRA method is able to detect small changes in binding free energy with a sensitivity compar

25 ublished revised guidance that recommended a change in blood donor deferral of men who have sex with

26 ch has not lead to irreversible pathological changes in blood flow and kidney tissue, and provides re

27 st immune response to HIV-1 and suggest that changes in blood pDC frequency and function can be used

28 lting in >=8% body weight loss, during which changes in body composition (by DXA) and appetite (by vi

29 Furthermore, the marked change in bone points coincides with a change in lithic

30 20.5 [95% CI, -11.2 to 52.2]; P = .21), and changes in bone marrow lesion size (-33 mm2 vs -6 mm2; b

31 nt locations were independently modulated by changes in both foreground and background reward rates.

32 Structural changes in both the peripapillary and macular retina and

33 However, previous studies focus on changes in brain activity related to motor execution.

34 ndardized effect sizes representing regional changes in brain sizes in cases of ADHD.

35 thyl phthalate results in measurable genomic changes in breast tissue with implications in breast car

36 ated variables as explanatory and subsequent changes in BW, BF%, and metabolic markers as response va

37 fication compared with those without uptake (change in calcium score, 97 [39-166] versus 35 [7-93] AU

38 ce were mechanosensitive (as demonstrated by changes in calcium flux under applied luminal flow).

39 Information on molecular changes in cancer-specific gene expression facilitates e

40 We followed changes in cardiac myocyte Ca(2+) and Na(+) regulation f

41 nd triglycerides are associated with adverse changes in cardiac structure and function, in particular

42 cores was the primary outcome measure, while change in CDVA was the secondary outcome measure.

43 ions treated with AZM, likely due to general changes in cell physiology as a result of the increased

44 f a 96-plex perturbation experiment revealed changes in cell population structure and transcriptional

45 main output constraint and ignores potential changes in cell volume.

46 ellular "second messenger," may be linked to changes in cellular architecture that favor pathogen-hos

47 lethal phenotypes are strongly modulated by changes in cellular conditions or genetic context, the l

48 of prolonged treatments, indicating durable changes in cellular physiologic identity.

49 Cs also have the greatest disease-associated changes in chromatin accessibility and the strongest alt

50 d hybrid speciation (HHS), which involves no change in chromosome number, is an important mechanism o

51 s a consequence of these migrations, or with changes in climate.

52 ated carbon dynamics are highly sensitive to changes in climate.

53 mes were the molecular diagnostic yield, the change in clinical management after the ultra-rapid exom

54 Change in clinical management for culture-positive eyes

55 of life, followed by hippocampal atrophy and changes in cognition in the fifth decade of life.

56 nd adjusted to experimental data to describe changes in concentration in cowpea seed during two germi

57 actile work was held constant via reciprocal changes in contraction frequency: (1) low fibre recruitm

58 Changes in coordination between these two essential orga

59 Changes in coronary artery, thoracic aorta, and cardiac

60 ng was manifest in the bimanual condition as changes in corticomotor excitability, mu (9-14 Hz), and

61 or enabled the detection of oxygen-dependent changes in COX-2 activity that are independent of protei

62 AKI is defined using changes in creatinine from baseline.

63 Interventions that led to changes in degree of AI and AS did not seem to influence

64 With these expected changes in dental insurance coverage, the average dental

65 During adulthood, stress unmasked persistent changes in DHPG-induced LTD and behavior that were not p

66 71.4% had therapeutic targets and 5.2% had a change in diagnosis.

67 ggest they have potential to encourage small changes in diet, which could be beneficial at the popula

68 nsional (2D) array, with osmotically induced changes in droplet volume being used to measure cell met

69 nge in esophageal pressure (DeltaPes), tidal change in dynamic transpulmonary pressure (DeltaPl), exp

70 cate occupancy to the active site via subtle changes in dynamics, enabling exquisite fine-tuning of d

71 In study 1, the change in EGP (baseline to last hour of EGP measurement)

72 vertebral artery blood flow, independent of changes in end-tidal PCO2 and blood pressure External ca

73 in yield in citric acid media increased with change in energy density from 0.34 +/- 0.09% at 0.1 kJ/c

74 This study characterizes annual changes in enrollment of Medicare and non-Medicare patie

75 Changes in ensemble activity differ significantly betwee

76 Aberrant changes in epigenetic modifications are closely involved

77 ce specific motifs to measure spatiotemporal changes in ERK activity.

78 Clinical features, tidal change in esophageal pressure (DeltaPes), tidal change i

79 in three different protocols involving step changes in exercise load and compared the results to lab

80 14% of the boundary deletions resulted in a change in expression in nearby genes of more than twofol

81 We also aimed to identify changes in expression and subcellular distribution of pr

82 t plants, loss of the ZmNLP5 function led to changes in expression for a significant number of genes

83 teomic approach to quantify systemically the changes in expression of small GTPase proteins in cells

84 Changes in expression of some microRNAs, including miR-1

85 int scale (5-PS), and by calculating percent change in FDG uptake (change in standardized uptake valu

86 In adipose tissue biopsies, changes in fibrosis were evaluated by immunohistological

87 We found age-dependent changes in five song traits (duration, maximum frequency

88 act that assessments of thermal gradients by changes in fluorescence of temperature-sensitive fluores

89 ied 102 metabolic reactions with significant change in flux in MG1655:: tetA when grown in the presen

90 Purified UNC-45B mutants showed changes in folding and solubility.

91 This change in foraging may have resulted from altered distri

92 l gene expression patterns are predictive of changes in FOS correlation networks in the morphine-depe

93 hly electrode dependent: On some electrodes, changes in frequency were perceptually distinguishable f

94 By investigation of the changes in gene expression and functional screening usin

95 mammalian homologs, MLL3/4, cause only minor changes in gene expression compared with whole-gene dele

96 available that has investigated genome-wide changes in gene expression during the normal physiologic

97 hat feeding causes substantial and transient changes in gene expression in the livers of both mouse s

98 imary follicle and is accompanied by dynamic changes in gene expression(1), but the gene regulatory n

99 Changes in gene regulation underlie much of phenotypic e

100 . varius and A. zeteki populations, describe changes in genetic diversity over time, assess the relat

101 Achieving step changes in genetic yield potential is crucial to ensure

102 e traits have evolved through cis-regulatory changes in genome sequence that influence the magnitude,

103 s revealed that ultrasound treatment induced changes in grain crystallinity These changes affected th

104 human primates, but there were immunological changes in granulomas and lymph nodes from anti-IL-10-tr

105 v) how g(m) responds to long- and short-term changes in growth and measurement environmental conditio

106 Using a simple model we show that the changes in growth are driven by the energy cost for the

107 re thought to be responsible for age-related changes in haematopoiesis that include a decline in lymp

108 We propose a simple technique to monitor changes in hemolysis levels continuously and in real tim

109 d P450s are affected by xenobiotic exposure, changes in HO-1 expression can potentially affect P450 f

110 ions for global ecology and for anticipating changes in host use during ongoing distributional shifts

111 There was no change in IGF-1 level from before to after surgery.

112 ARP-2-deficiency host-mice revealed a global change in immunological profile and impaired recruitment

113 However, the early and nonadopter changes in implantation rates were not statistically dif

114 sitively related with that of g(s) , with no changes in instantaneous water-use efficiency and only s

115 rs, are the main contributor to the observed changes in interfacial reactivity upon illumination.

116 th exercise and passive heat stress, with no change in internal carotid artery blood flow Neurovascul

117 en implicated in human bipolar disorder, and changes in intestinal microbiota.

118 ffects of microgravity by measuring combined changes in intracranial volumetric parameters, pituitary

119 The change in IOP following washout for patients using 0 (n

120 This computational study determined changes in IQ [peak IQ, best focus and depth of focus (D

121 visit (i.e., concurrently) and whether early changes in irritability with antidepressant treatment pr

122 and reperfusion, is associated with profound changes in key processes of intercellular communication,

123 e prespecified secondary outcomes, including changes in knee pain assessed by a visual analog scale (

124 rence, 5.2 [95% CI, -2.3 to 12.8]; P = .17), changes in knee pain assessed by the Western Ontario and

125 Drawing on polymer theory, we use this change in lifetime to calculate steric pressure as a fun

126 arked change in bone points coincides with a change in lithic technology.

127 was associated with greater dysbiosis but no change in liver histology.

128 n and reduced protein synthesis but no major changes in m(2) (6,6)A levels in 18S rRNA.

129 Changes in melting temperature and transitional pH depen

130 of hepatitis C virus (HCV) results in rapid changes in metabolic parameters early in direct-acting a

131 e also found that lithium-induced behavioral changes in mice were phenocopied by modulation of the ci

132 is common in this cohort and associated with changes in microbial community composition.

133 apt to their environment through coordinated changes in mitochondrial function and metabolism.

134 Changes in molecular compositions were accompanied by a

135 dergoes apoptotic cell death, it experiences changes in morphology and ion concentrations.

136 nonadherent conditions in vitro and analyzed changes in mRNA and protein levels to identify mechanism

137 Currently, studying mitochondrial changes in multiple sclerosis is hampered by a paucity o

138 Resulting changes in muscle-specific gene expression that take pla

139 myosin suggest that dATP induces structural changes in myosin heads that increase the surface area o

140 emonstrate that in addition to antigenicity, changes in N-linked glycosylation sites can alter other

141 ormed serial breath tests to monitor dynamic changes in neutrophil elastase activity during lung infe

142 Changes in nicotinamide adenine dinucleotide (NAD(+)) le

143 oral code in conveying key information about changes in nociceptive output in pathologic conditions,

144 dsRNA binding induces allosteric structural changes in OAS1 that reorganize its catalytic center to

145 rannual timescales are steric changes due to changes in ocean heat content and barystatic changes due

146 and fetal compartments and causes behavioral changes in offspring.

147 show that ompR expression was not altered by changes in osmolarity but instead was induced by membran

148 The first conformational change in our dataset involves rotation of the inner-gat

149 Changes in our environment associated with modernization

150 r than what would be predicted from parallel changes in overall brain anatomy.

151 is could not be attributed conclusively to a change in ownership because differential improvement occ

152 was acquired using a 52-channel system, and changes in oxy-haemoglobin in the frontal and temporal r

153 ased cellular metabolic rates in vitro using changes in oxygen consumption rate as a readout.

154 tially affect P450 function and, conversely, changes in P450 expression can influence HO-1.

155 (SEFL) model of PTSD, as well as associated changes in pain sensitivity.

156 ctural MRI) predicted longitudinal cognitive changes in patients with Alzheimer's disease pathology.

157 ings shed light on allosteric conformational changes in PCSK9 required for high-affinity binding to L

158 Primary outcome measures were changes in perimetric mean deviation (PMD) on Humphrey V

159 aim of this study was to obtain estimates of changes in perioperative outcomes and utilization of bar

160 We quantified the annualized rates of change in peripapillary retinal nerve fiber layer, gangl

161 In humans, age-related changes in personality occur in a non-random fashion wit

162 n parameters are dynamically adjusted to any change in pH and temperature during the sport practice b

163 tous polymers in cells, often in response to changes in physiological conditions.

164 itor of plasminogen activation, and measured changes in plasmin (ogen) uria.

165 ine were radical in nature and resulted in a change in polarity from a polar to non-polar molecule, w

166 195G was radical in nature and resulted in a change in polarity from a polar to non-polar molecule.

167 ation change through time is associated with changes in population composition as a consequence of th

168 Ecological communities often show changes in populations and their interactions over time.

169 observed increase in fish production, while changes in predator-prey interactions cannot.

170 nted fault valving behavior, that is, cyclic changes in pressure and unsteady fluid migration along f

171 bstrate utilization, which is facilitated by changes in protein abundances for substrate uptake and i

172 ved DNA-binding regions can lead to profound changes in protein function.

173 it appears that evolutionary change involved changes in protein-protein interactions to favor Cas2 bi

174 period from 1962 to 2015 and no significant change in Pseudoterranova spp. abundance over a 37 year

175 ups and the association between longitudinal changes in R2* values and cognition in the AD group.

176 s of endogenous mRNA targets that respond to changes in RBP level, recapitulating effects observed in

177 It was shown previously that a change in receptor specificity is a hallmark for adaptat

178 l-free approach for assessing conformational changes in receptors in living cells at ambient conditio

179 replacement of forbs by grasses resulted in changes in relative abundance across trophic levels, wit

180 EG to assess tDCS-induced neurophysiological changes in relative power and MSE computed on the pre-st

181 petition are therefore likely to have driven changes in relative testes size in opposing directions.

182 may play a fundamental role in age-dependent changes in reproductive success.

183 s renal injury in RVD patients, but does not change in response to medical or interventional therapy

184 Mitral cells (MCs) showed more diverse changes in response patterns over time as compared with

185 Brain changes in response to binge EtOH treatment were more pr

186 Stem cells undergo dynamic changes in response to injury to regenerate lost cells.

187 This study aimed to evaluate longitudinal changes in retinal blood flow in response to flicker sti

188 ng throughout the Gulf of Maine and apparent changes in right whale migratory dynamics.

189 rely ischemic at baseline had no significant changes in RNP area 1 year after PRP.

190 aces revealed that P. glomerata could effect changes in Se/Te distribution and concentration indicati

191 r upon spin transition that correlate to the change in sensitivity.

192 disposed irregular 5-HT receptor density, or change in sensory bombardment may enhance internal broad

193 nges in amplitude-seemingly giving rise to a change in sensory quality; on others, they were not.

194 autism spectrum disorders and neural circuit changes in several brain areas, but the cellular mechani

195 We revealed hierarchical changes in skin cell biology, including activation of an

196 However, the mechanisms underlying changes in soil C storage are not well understood, hampe

197 ation and a two-pool model, we then explored changes in soil labile and stable C decomposition along

198 agent suggest that channel gating involves a change in solute-inaccessible volume in the CTD of ~1,90

199 Despite no net change in species richness at the spatial scale of a stu

200 by calculating percent change in FDG uptake (change in standardized uptake value [DeltaSUV]).

201 cts linear models to analyze associations of changes in standardized weight, length/height, and body

202 hibition of HIV-1 maturation by BVM involves changes in structure and dynamics that are surprisingly

203 EOC MCAs displayed significant LPA-induced changes in surface ultrastructure with the loss of cell

204 rrelation of force with position' and SC as 'change in sway'.

205 Little is known about the changes in symptom classification over time in patients

206 pheral artery disease and the association of changes in symptom classification with subsequent cardio

207 hibit hemispheric asymmetry, we investigated changes in synaptic plasticity and neuronal excitability

208 Mean change in systolic blood pressure was 3.4 mm Hg (95% CI,

209 pine lakes and streams will experience major changes in temperature regimes, absolute and relative in

210 idation is reversible when there is no gross change in the coordination geometry upon a change in the

211 generalized estimating equations to estimate change in the degree of photoaging associated with incre

212 scenario, the presence of effector causes a change in the DeltaH associated with substrate binding.

213 This electrostatic term depends on the change in the electrostatic interaction between the char

214 A significant change in the lipid-packing order takes place during ass

215 e able to predict accurately the temperature change in the North Atlantic.

216 e of a stable ocular surface, as assessed by change in the ocular surface severity scores was the pri

217 GA score for the intertriginous area and the change in the Psoriasis Area and Severity Index (PASI) s

218 also suggest an accelerating role of climate change in the range expansion of M. soledadinus, with po

219 s change in the coordination geometry upon a change in the redox state.

220 ry or neuropathic hyperexcitability led to a change in the temporal pattern of AP firing, emphasizing

221 Mechanistic studies suggest a change in the turnover-limiting and selectivity-determin

222 nce, and its significance, in rates of RNFLT change in the UKGTS treatment arms was enhanced and RNFL

223 Fire-induced changes in the abundance and distribution of organisms,

224 man disturbance in tropical forests, driving changes in the abundance of vertebrate and invertebrate

225 tor binding is accompanied by conformational changes in the active site, including the translation of

226 ndings indicate, most strikingly, that small changes in the activity of PTP1B can cause large shifts

227 volutionary feedbacks may help to understand changes in the adaptive potential after disturbance of m

228 In addition, we suggest how changes in the association of lipid-binding caveolar pro

229 plex daily rhythms characterized by profound changes in the association, from gene expression to beha

230 Small structural changes in the axial coordinating linkers result in dram

231 We interrogated our model by investigating changes in the capacitance induced by ligand binding to

232 noncontingent model, to investigate whether changes in the cerebrovascular system in the PFC contrib

233 dividuals, acute exercise elicits widespread changes in the circulating metabolome.

234 y formation with Gaussian processes to model changes in the community structure as a smooth function

235 ssessing prevalence ratios, differences, and changes in the concentration of pathogen genes and host-

236 e for short-term (possibly years to decades) changes in the contemporary environment that might not o

237 ived product made from fresh onion, produces changes in the content of flavonoids, organosulfur compo

238 and reaction times increased for orientation changes in the contralateral but not ipsilateral visual

239 miRSwitch highlights potential changes in the distribution of mature miRNAs from the sa

240 a global-scale meta-analysis to quantify how changes in the diversity of organic matter derived from

241 ement under ambient conditions through local changes in the droplet curvature.

242 identify the SAM-binding region and observe changes in the dynamics of the loops that form the knot.

243 f the central stalk, inducing conformational changes in the F(1) motor that catalyzes ATP production.

244 Changes in the geological sulfur cycle are inferred from

245 ntrolled swine farm environments on temporal changes in the gut microbiome and resistome of veterinar

246 rction (MI) causes structural and functional changes in the heart leading to heart failure.

247 ooked mechanism for explaining decadal-scale changes in the land carbon sink and highlight the import

248 (7-10), and transport experiments have shown changes in the Landau level degeneracy at fillings corre

249 Patients with AH exhibited specific changes in the levels of intermediates of glycolysis/glu

250 Changes in the levels of metabolic hormones (glucocortic

251 Other changes in the liver included hepatic steatosis, portal

252 mmHg to as high as 22 mmHg, causes striking changes in the loading environment in the peritoneal cav

253 In contrast, changes in the microbial community were minor and transi

254 rn diet promotes tumor recurrence, including changes in the microbiome, in mice that underwent colore

255 study identifies sex- and age-specific gene changes in the mTORC1-activated lung mesenchyme and esta

256 s work is to investigate whether appropriate changes in the nature of the spacer could modulate the i

257 Mild-to-moderate changes in the ocular adnexa can develop in children and

258 nsformations of the photoacid generators and changes in the optical properties of the QDs at each pat

259 exposure experiments showed ultrastructural changes in the photophore similar to those seen in crust

260 we define as effects that do not derive from changes in the protein's ability to perform its physiolo

261 yield massive, finely-controlled, and stable changes in the Seebeck coefficient, switching a poor non

262 Reserpine induced changes in the sleep architecture with more transitions

263 Changes in the spatial and temporal thermal fluctuations

264 disordered proteins involve a wide range of changes in the structure and dynamics of the partners in

265 dely implicated as the source of large-scale changes in the subpolar marine environment.

266 haracterize the impact of age on the overall changes in the systemic inflammation profiles in subpopu

267 mpanied by elevated sensitivity to perceived changes in the task environment.

268 lly modern humans (Homo sapiens) evolved via changes in the thorax, pelvis and limbs.

269 Climate change causes changes in the timing of life cycle events across all tr

270 mycobacteria, we characterized the temporal changes in the transcriptome of synchronously replicatin

271 xial coordinating linkers result in dramatic changes in the transport properties of the metalloporphy

272 that cytotoxic chemotherapies induce dynamic changes in the tumor immune microenvironment that vary b

273 We focus on developmental changes in the ventricular system and CSF sources (inclu

274 al time, the critical period, trigger robust changes in the visual cortex.

275 Raman spectroscopy to noninvasively monitor changes in the water content within biological tissues.

276 Why metalloenzymes often show dramatic changes in their catalytic activity when subjected to ch

277 hough control individuals exhibited temporal changes in their response times, a clear effect of tempe

278 biotic-related adverse effects necessitating change in therapy.

279 little of the genetic mechanisms underlying changes in these mate preference behaviours.

280 onstrated assessment of spatial and temporal changes in these parameters within calf muscles during r

281 Change in theta, but not alpha power, between meditation

282 nt for the older subjects, consistent with a change in tissue elasticity with age.

283 A transcriptome analysis showed a change in tissue expression from gills, in marine verteb

284 Gradual population-level changes in tissues can be driven by stochastic plasticit

285 connectivity, and (3) local and distributed changes in TMS/EEG potentials.

286 with ceCT, (68)Ga-FAPI PET/CT results led to changes in TNM staging in 10 of 19 patients.

287 Here, we examined the global AS changes in tomato leaves infected with Phytophthora infe

288 The primary efficacy end point, percentage change in total plaque volume at 90 days by intravascula

289 tion growth can be substantially affected by changes in traits that are variable under environmental

290 staging of disease in 3 (14%) patients and a change in treatment in 4 (19%) patients.

291 greement, only LY344864 induced neuroplastic changes in trigeminal sensory afferents, increasing calc

292 des for all five species, suggesting minimal changes in trophic levels.

293 While tissue homogenate showed no changes in tubulin acetylation between control, depresse

294 Changes in USL microstructure and corresponding mechanic

295 oth the peripapillary and macular retina and changes in vascular parameters have been identified.

296 Main outcome measures were change in visual acuity and the proportion of patients g

297 ticity, neuroscientists have understood that changes in visual experience during a discrete developme

298 l-studied taxa, such as vertebrates, reflect changes in wider biodiversity.

299 However, we know little about how changes in winter snowfall will affect ecosystem product

300 epeated OW applications, and (iv) no radical change in Zn speciation was observed at the end of the 1