ライフサイエンスコーパス: channel

1 f collection medium, is formed in the curved channel.

2 that it functions as an outwardly rectifying channel.

3 flat plate in a low-turbulence laminar water channel.

4 nel of substrates that aberrantly occupy the channel.

5 moiety-bearing polymer layer on the graphene channel.

6 es as cells transit through the constriction channel.

7 urrently flowing in a microfluidic Hele-Shaw channel.

8 -helices, thus blocking the substrate access channel.

9 unrecognized deep flow toward the Faroe Bank Channel.

10 tion by PIP(2); and cholesterol inhibits the channel.

11 on of a flux of surface excitations from the channel.

12 bound directly to the walls of the titanium channels.

13 erisation of the protein into functional ion channels.

14 n are Ca(2+) release-activated Ca(2+) (CRAC) channels.

15 conductance Ca(2+)-activated potassium (SKs) channels.

16 e mechanism for CBD interactions with sodium channels.

17 el HCN2 in the family of so-called pacemaker channels.

18 synaptic neurotransmitter receptors and ion channels.

19 the hair cell mechanoelectrical transduction channels.

20 guest entrance to and transport through the channels.

21 ity of carboxyfluorescein-permeable membrane channels.

22 ngineered transient receptor potential (TRP) channels.

23 influx of extracellular calcium through ion channels.

24 ny advances in the study of acid-sensing ion channels.

25 ross a single microcapillary or microfluidic channels.

26 he binding sites along the pore of potassium channels.

27 at a rate similar to those of natural proton channels.

28 protein 150) enhances the activity of TRPV4 channels.

29 reduced by inhibiting Ca(2+) influx via Orai channels.

30 vestigating the stoichiometry of Kv2.1/Kv6.4 channels.

31 des begin to scatter light into many spatial channels.

32 SF gating properties among the family of K2P channels.

33 nd functionality of HUVEC-lined microfluidic channels.

34 ism for SthK, and potentially eukaryotic HCN channels.

35 ls through voltage-dependent Ca(2+) (Ca(V) ) channels.

36 in tension sensitivity among these membrane channels.

37 n evolutionarily conserved regulator of Slo2 channels.

38 potassium current generated by neuronal Kv7 channels.

39 gmentation of Ca(V)1.2 voltage-gated calcium channels(1-4).

40 A single-channel (2 m x 125 bps) prototype and an 8-channel frequ

41 43 gene knock-down; (2) antagonists of TRPV4 channels; (3) antagonist of P2Y(1) receptors for ATP; an

42 ted (N, O)(Ph, C(6)H(4), C) oxaphosphetanes (Channel A), whereas MoBA compounds decomposed faster via

43 l (4, 5)-bisphosphate (PIP(2)) activates the channel; a secondary anionic lipid site has been identif

44 tly reduces principal cell epithelial sodium channel abundance and function.

45 ane environment provide unique insights into channel activation and inactivation mechanisms.

46 le AMPA receptor upregulation, L-type Ca(2+) channel activation, enhanced spine Ca(2+) transients, nu

47 Furthermore, K(+) -uptake-channel activities were reduced in cpk3/5/6/11/23 quintu

48 ted the relationship between bioelectric ion channel activity and calcium, finding that cell hyperpol

49 Ca(2+)](ER) is a major regulator of InsP(3)R channel activity and InsP(3)R-mediated [Ca(2+)](i) signa

50 , and pharmacological modulators alter TREK1 channel activity and overlaps with positions found to mo

51 Deletion of Trpm7 and inhibition of TRPM7 channel activity by the FDA-approved drug FTY720 increas

52 of WT vessels, suggesting that basal K(ATP) channel activity in LSM is not an essential component of

53 t the structure, stability and intercellular channel activity of gap junctions; however, the molecula

54 phorylation on its N terminus increases this channel activity.

55 nd basolateral surfaces of the cholangiocyte channel, allowing proof-of-concept toxicity studies with

56 the significant set of voltage-gated calcium channels among CNVs called from both exome sequencing an

57 The succession comprises channel and barform packages which together demonstrate

58 ur current understanding of ligand-gated ion channel and G protein-coupled receptor complexes and dis

59 projecting into one side of the microfluidic channel and is easily integrated with upstream electroni

60 ivates the channel, we docked menthol to the channel and systematically validated our menthol binding

61 connection and interruption of the cofactor channel and the substrate channel via the conformational

62 d leaf and root anatomy, up-regulation of Si channel and transporter genes, ascorbate-glutathione cyc

63 is a highly selective, Na(+)/K(+)-conducting channel and, in contrast to known cation channelrhodopsi

64 uorinated analog of 4AP, also binds to K(V)1 channels and can be used as a PET tracer for the detecti

65 bly of heteromeric KCNQ2/KCNQ3 (Kv7.2/Kv7.3) channels and demonstrates that large disease-linked and

66 ncreases are prevented by blockade of Ca(2+) channels and depend on downstream recruitment of Ca(2+)-

67 iate- and small-conductance K(+) (IK and SK) channels and endothelial nitric oxide synthase (eNOS) ar

68 previously unknown architecture of pannexin channels and establishes a foundation for understanding

69 tically were confirmed to be mediated by ion channels and experimental data suggests an insignificant

70 receptor proteins, such as ligand-gated ion channels and G protein-coupled receptors, has directly e

71 These findings suggest that when TRP channels and GPCRs are co-expressed in the same tissues,

72 Transmembrane channels and pores have key roles in fundamental biologi

73 lar thermosensors, including thermosensitive channels and receptors, act as the initial detectors of

74 findings suggest a key role of cardiac Orai1 channels and the potential for Orai1 channel inhibitors

75 sential to determine their complement of ion channels and to understand the function of biological ci

76 nt with antagonists of both acid-sensing ion channels and transient receptor potential vanilloid type

77 ion of ZDHHC14 mirrors that of PSD93 and Kv1 channels and, consistent with ZDHHC14's importance for K

78 Divergent responses to the K-channel antagonist, kappaM-conopeptide RIIIJ (RIIIJ), re

79 cluding myelin, axonal cytoskeleton, and ion channel antigens, in individual patients.

80 and functional features of biological water channels (aquaporins).

81 t receptor potential vanilloid 4 (TRPV4) ion channels are a major Ca(2+) influx pathway in endothelia

82 Thus, PKD2 channels are a major component of functional flow sensin

83 While it is known that BK channels are activated by voltage and Ca(2+), and that v

84 Mechanosensitive ion channels are crucial for normal cell function and facili

85 Mammalian Piezo2 channels are essential for transduction of innocuous mec

86 truncate the C terminus of neuronal Kv7/KCNQ channels are linked to a spectrum of seizure disorders.

87 rsistent firing when clusters of cooperative channels are present together with non-cooperative spike

88 Biological proton channels are sub-1-nm protein pores with ultrahigh proto

89 Artificial water channels are synthetic molecules that aim to mimic the s

90 Large-conductance potassium (BK) channels are transmembrane (TM) proteins that can be syn

91 idic systems flowing through multiple outlet channels are typically conducted off-line through micros

92 Toward this end, we exploited gramicidin channels as molecular force probes and developed in sili

93 o-residue segments of substrate in the axial channel, as observed for other AAA+ proteases and protei

94 e sequence homology between acid-sensing ion channels (ASICs) and epithelial sodium channel (ENaCs),

95 y is reminiscent of multisubunit protein ion channels assembled with incorrect monomer stoichiometrie

96 l external over-the-scope additional working channel (AWC) (Ovesco, Tuebingen, Germany) was utilized

97 n involving a M(B2) permutational mechanism (Channel B).

98 ockchain to provide "off-chain" fast payment channels between users, which means that not all transac

99 Exposure to 10 or 25 uM ivabradine-an open channel blocker of HCNs-for 24 h resulted in a dose-depe

100 issue, intrathecal administration of a KV1.3 channel blocker or a glutaminase inhibitor ameliorated d

101 Calcium channel blockers (CCB) improve TB treatment outcomes in

102 beta-blockers or nondihydropyridine calcium channel blockers are reasonable drugs in patients with n

103 Ps do not directly interact with embedded gA channels but perturb the local properties of lipid bilay

104 the degree and rate of inhibition of Nav1.7 channels by the aryl sulfonamide compound PF-05089771, c

105 approximants that estimate stationary single-channel Ca(2+) nanodomains with great accuracy in broad

106 mple, buffer fluid and even the microfluidic channel can be modified in this model.

107 new evidence that both the 3-fold and 4-fold channels can be functional in ferritin.

108 expressed in the same tissues, many of these channels can inhibit GPCR desensitization.

109 te that clusters of strongly cooperative ion channels can plausibly form bistable conductances.

110 e of CRISPR/Cas9 HDR for gene integration in channel catfish and may contribute to the generation of

111 A role for L-type Ca(2+) channels (Cav(L)) and anoctamin 1 (ANO1) was tested sinc

112 Previous studies have shown that sodium channels cluster together in specific cellular subdomain

113 consistent with ZDHHC14's importance for Kv1 channel clustering, loss of ZDHHC14 decreases outward cu

114 This RGC network forms a new electrical channel combining the ON and OFF feedforward pathways wi

115 rial calcium uniporter is a Ca(2+)-gated ion channel complex that controls mitochondrial Ca(2+) entry

116 g can occur directly from the initial closed-channel complex.

117 These data indicate that often occurring TRP channel complexes regulate diversity in neuronal sensiti

118 secting the phospholipid requirements of ion channel complexes.

119 Voltage-gated sodium channels comprise an ion-selective alpha-subunit and one

120 Their porosity consists of a one-dimensional channel connected to three peripheral pockets.

121 were blocked by (1) antagonists of connexin channels, connexin 43 (Cx43) blocking peptide Gap26, or

122 dressed these questions by carrying out high channel count recordings in dorsal-lateral prefrontal co

123 arrays described in previous reports had low channel counts and required time-consuming manual assemb

124 show that tatM2NX inhibits over 90% of TRPM2 channel currents at concentrations as low as 2 muM.

125 older slides make for a total of eight known channel-damming landslide events at the same location ov

126 Voltage-gated potassium (Kv) channels display several types of inactivation processes

127 Through this mechanism, sodium channels effectively measure the frequency of action pot

128 Here, using single-channel electrical recording in planar lipid bilayers in

129 Ca(2+) release-activated Ca(2+) (CRAC) channels elevate cytoplasmic Ca(2+) concentration, which

130 g ion channels (ASICs) and epithelial sodium channel (ENaCs), these channel families display very dif

131 y, high frequency users of digital financial channels exhibit enhanced activation of brain areas link

132 as caused by acid activation of these cation channels expressed in airway sensory nerves.

133 otential duration were reduced and potassium channel expression (Kv1.5) and current (I(Kur)) and F(2)

134 The increase in Kv11.1 channel expression closely followed the time-course of t

135 KCNJ2 K(+) channel expression in peripheral blood mononuclear cell,

136 ctrophysiological properties, mechanosensory channel expression, and vulnerability to ototoxin in a h

137 Cardiac sodium channel expression, I(Na) and atrial action potential du

138 and western blotting were used to assess ion channel expression.

139 and epithelial sodium channel (ENaCs), these channel families display very different functional chara

140 PIEZO2 is the essential transduction channel for touch discrimination, vibration, and proprio

141 serving as highly interconnected conducting channels for carrier transport.

142 rk opens an avenue to develop functional MOF channels for selective ion conduction and efficient ion

143 X-ROS primes intracellular calcium (Ca(2+) ) channels for synchronized activation in the healthy hear

144 stitutions, to identify regions required for channel formation and pH gating in planar lipid bilayers

145 identify the critical conditions triggering channel formation and the emergence of characteristic va

146 ntly, the mechanism and domains required for channel formation have yet to be elucidated, although a

147 olved in Kv4.2/KChIP3 somatodendritic A-type channel formation, trafficking, and function, a feature

148 hat without forming an atomically structured channel, four-monomer-based random heteropolymers (RHPs)

149 e-channel (2 m x 125 bps) prototype and an 8-channel frequency-division multiplexed (0.5 m x 1,000 bp

150 SthK, a cyclic nucleotide-modulated ion channel from Spirochaeta thermophila, activates slowly u

151 Vascular K(ATP) channel function (topical glibenclamide superfused onto

152 of the four stillbirth mutants on TRPM7 ion channel function in heterologous cells.

153 Surprisingly, the channel function is dispensable.

154 PKA-dependent phosphorylation effects on SK2 channel function.

155 has been tested indirectly through assays of channel function.

156 ectron microscopy (cryo-EM) structure of the channel functionally arrested by tarantula toxin.

157 presence of an osmoticant agent suggest that channel gating involves a change in solute-inaccessible

158 cilitated studies of the structural basis of channel gating.

159 rug-induced (sea anemone toxin, ATXII) Na(+) channel GOF isolated heart model and modulate extracellu

160 A native calcium ion channel has been identified in bacteria for the first ti

161 tion of hyperpolarization-activated f-(HCN4) channels has been abolished (HCN4-CNBD).

162 Mechanotransduction channels have been proposed as force sensors in various

163 zation-activated and cyclic nucleotide-gated channel HCN2 in the family of so-called pacemaker channe

164 TrkH is a bacterial ion channel implicated in K(+) uptake and pH regulation.

165 dvance our understanding of the role of this channel in physiology and pathophysiology and inform new

166 oxygen species activate a large conductance channel in the inner mitochondrial membrane known as the

167 g, suggesting APOL1 forms a cytotoxic cation channel in the parasite plasma membrane.

168 r, and inositol 1,4,5-trisphosphate receptor channel in various kidney diseases.

169 nce causes FXS, differentially modulates HCN channels in CA1 versus L5 PFC dendrites.

170 that TMC1/2 cannot form mechanotransduction channels in cochlear hair cells without TMIE.

171 Spontaneous Ca(2+) transients activate Ano1 channels in ICC-SS.

172 found that palmitate up-regulates pannexin-1 channels in macrophages that mediate the attraction of n

173 ealing a trimeric cylinder that forms single channels in phospholipid bilayers.

174 n currents via GLUTAMATE RECEPTOR-LIKE (GLR) channels in root protoplasts.

175 n of contraction, a mechanism by which those channels in smooth muscle are thought to be targets of e

176 ew, we focus on PIP(2) as a regulator of ion channels in smooth muscle cells and endothelial cells-th

177 arterial smooth muscle cells is to form K(+) channels in the sarcolemma.

178 aled a critical and selective role for K(v)1 channel inactivation in synaptic facilitation of excitat

179 a(2+) influx through NMDA receptors leads to channel inactivation through a process mediated by resid

180 features as human Ca(V)2.1 and other Ca(V)2 channels, including high voltage-activated currents that

181 nt structural motifs for ion selectivity and channel inhibition in Panx1.

182 ur findings demonstrate that systemic K(ATP) channel inhibition reduces V O(2) max and critical speed

183 pathway, providing a molecular mechanism for channel inhibition.

184 c Orai1 channels and the potential for Orai1 channel inhibitors as inotropic therapies for maintainin

185 tivation gating, and reveals multiple ligand-channel interactions that stabilize this permissive conf

186 nduced myotonia and to evaluate block of the channels involved as a novel approach to therapy.

187 Our goal was to identify ion channels involved in mechanically induced myotonia and t

188 heir selectivity for human voltage-gated ion channels involved in the ventricular action potential.

189 sient receptor potential vanilloid 1 (TRPV1) channel is activated by heat and by capsaicin, the punge

190 TSPAN-7 modulation of beta-cell L-type Ca(V) channels is a key determinant of beta-cell glucose-stimu

191 compounds that modulate the skeletal muscle channel isoform (RyR1) interaction with calmodulin and F

192 200-fold selectivity over off-target sodium channel isoforms, Na(V)1.1-1.6 and Na(V)1.8.

193 work quickly to capture that enthusiasm and channel it into a social good, lest we lose this opportu

194 Two-pore-domain potassium channels (K(2P)) are the major determinants of the backg

195 specific blocker of voltage-gated potassium channels (K(V)1 family) clinically approved for the symp

196 Inward rectifier potassium channel (Kir) Kir2.2 has multiple interactions with plas

197 prolongation (~50%), reduced L-type calcium channel (LCC) current (~33%), reduced outward potassium

198 ices with the optimal flow rate (1 mL/h) and channel length (2 cm) were demonstrated to test three ki

199 of PH(2)(-) is steered to the S(N)2 reaction channel (less-destabilizing activation strain).

200 ate modules featuring voltage-dependent Ca2+-channels link these outputs to the downstream dynamics a

201 enzymes, ABHD17a and ABHD17c, that excise BK channel lipid groups with remarkable precision.

202 ion metal dichalcogenides as next-generation channel materials is discussed.

203 e semiconductors have partly replaced a-Si:H channel materials.

204 ing and the ictal increase of T-type calcium channel-mediated burst firing of thalamocortical neurons

205 pected stimulus-dependent diversity in Na(V) channel-mediated itch signalling.

206 ource of Ca(2+) affects CDI, we recorded one-channel Na(+) currents to quantify the receptor gating m

207 tudied mice haplo-insufficient for the Na(+) channel Na(v)1.5 (Na(v)1.5(+/)) and mice in which the cA

208 structural discrepancies on mechanosensitive channel nanopockets are known to affect mechanical gatin

209 is a large and complex coastal system whose channel network is vulnerable to morphological changes c

210 The hierarchy of channel networks in landscapes displays features that ar

211 preferential delivery of coarse material to channel networks that initiate debris flows.

212 The mechanosensitive channel of small conductance (MscS) is the prototype of

213 We showed that mouse cholangiocytes in the channel of the device became polarized and formed mature

214 ghly selective and tightly controlled Ca(2+) channel of the inner mitochondrial membrane that regulat

215 binds to 18S ribosomal RNA in the mRNA entry channel of the ribosome and leads to global inhibition o

216 populations(6) and they represent formation channels of compact-object mergers(7).

217 tion of pore partition agents into hexagonal channels of MIL-88 type (acs topology) endows materials

218 cence signal between the red and green color channels of phone images to overcome a strong evaporatio

219 Triply bound dinitrogen molecules occupy channels of these frameworks.

220 Canaliculi are linked to smaller channels of ~40 nm diameter, occupying spaces between fi

221 lso - if economically convenient - to open a channel on the Lightning Network and transact "off chain

222 talk) between ryanodine receptor and IP(3)R channels on the Ca(2+) transient and examine the sensiti

223 ) oscillations, and the patch-clamped K(ATP) channel opened more frequently when glucose was high.

224 operated PKCdelta activity is obligatory for channel opening by PIP(2) , the probable activating liga

225 nction mutations in the mechanosensitive ion channel PIEZO1 were shown to ameliorate Plasmodium paras

226 anion-permeable pentameric ligand-gated ion channels (pLGICs).

227 100 deg, exposing different residues to the channel pore in the open and closed states.

228 heir mammalian counterparts, bacterial Na(V) channels possess a simpler, fourfold symmetric structure

229 Remarkably, the highly divergent channel possesses similar features as human Ca(V)2.1 and

230 75 is evolutionarily distinct from all known channels, predicting novel ion-selectivity and gating me

231 ding by lidocaine increasing the fraction of channels presenting a high-affinity binding site for PF-

232 a foundation for understanding their unique channel properties.

233 Mutations in the channel protein PKD2 cause autosomal dominant polycystic

234 y, however, mGluR1s boost neighboring T-type channels, providing a mechanism for local coincident det

235 the loops or termini of different GPCRs, ion channels, receptors and transporters without disrupting

236 How TRP channels reciprocally regulate GPCR signaling is less we

237 ed both in detergent-solubilized SthK and in channels reconstituted into lipid nanodiscs.

238 how intracellular pH affects mammalian TRPC channels remains obscure.

239 enriched in subcellular domains where Ca(V) channels reside, such as the cardiac dyad.

240 in KCNT1, the gene encoding Slack (K(Na)1.1) channels, result in epilepsy of infancy with migrating f

241 reveals a lipid-induced stabilization to the channel, resulting in a 3D reconstruction at 1.9 angstro

242 n on CaM's regulation of the calcium release channel, ryanodine receptor (RyR).

243 At least 5 ion channels show a circadian expression pattern in the vent

244 terised by pronounced downstream declines in channel size and local termination.

245 ic knockout (KO) of the calcium-activated K+ channel SK2 (L7-SK2) show intact vestibulo-ocular reflex

246 However, accurate reporting of the channel state and observation of allosteric regulation b

247 Platform's channels subject cell constructs to physiological fluid

248 e behaviour of lithium metal within the MIEC channels suggests that the chemical and mechanical stabi

249 shared structural feature between unrelated channels suggests the possibility of a unified mechanica

250 t biogeochemical implications: demethylation channels sulfur into the microbial food web, whereas cle

251 l fluency task (VFT) was acquired using a 52-channel system, and changes in oxy-haemoglobin in the fr

252 ope protein E, forms a homopentameric cation channel that is important for virus pathogenicity.

253 et al. (2020) describe TACAN, a putative ion channel that mediates mechanical pain in mice.

254 V4 channels, which are transmembrane calcium channels that can regulate vascular tone, in modulating

255 e macromolecules, forming a network of ionic channels that exhibit regulated permeability of water an

256 Similar to protein-conducting channels that facilitate movement of transmembrane segme

257 A receptors (NMDARs) are glutamate-gated ion channels that mediate fast excitatory synaptic transmiss

258 3) receptors are pentameric ligand-gated ion channels that regulate synaptic activity in the central

259 The potassium channel THIK-1 is strongly expressed in the central nerv

260 h regulation of the aquaporin-2 (AQP2) water channel. This action is widely accepted to be associated

261 on health and the shares of health spending channelled through non-profit and private insurance are

262 vestigated the evolutionary history of these channels to add an evolutionary context to the already a

263 examined the contribution of central K(ATP) channels to glucose effectiveness.

264 ibit pancreatic ATP-sensitive K(+) (K(ATP) ) channels to increase insulin release.

265 alyx synapse in coupling presynaptic calcium channels to release sites.

266 am recruitment of Ca(2+)-activated potassium channels to the plasma membrane.

267 ynamics through the lysosomal calcium efflux channel, transient receptor potential mucolipin 1 (TRPML

268 ulties in integrating complementary n- and p-channel transistors in a common quantum dot active layer

269 The rates of voltage-induced channel transition between the open and closed states me

270 alone laser during flow through microfluidic channels, trigger contents release with spatial and temp

271 The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve fib

272 tage/current and for EME performed in narrow channels/tubing where bubble formation is critical.

273 ere performed with four conformations of the channel: two closed state structures, an intermediate st

274 Changing activity of cardiac Ca(V)1.2 channels under basal conditions, during sympathetic acti

275 on of inwardly rectifying potassium (K(IR) ) channels underlies vasodilatation with elevated muscle f

276 ps with positions found to modulate TASK K2P channel VA sensitivity.

277 suggested that several voltage-gated Ca(2+) channels (VGCCs) regulated critical signaling events in

278 Submicromolar [Ca(2+) ] activates the channel via constitutively-bound calmodulin, whereas hig

279 on of the cofactor channel and the substrate channel via the conformational changes of its two cataly

280 present a unique, large group of light-gated channels (viral channelrhodopsins, VirChR1s).

281 n-coupled receptor, and activation of an ion channel voltage-sensor domain, unraveling features criti

282 ssential component of volume-regulated anion channels (VRAC), as a vital regulator of hypotonicity-in

283 of normalized MC signals in the MC detection channels was improved by employing seven-element-encoded

284 n of the KChIP3-mediated modulation of Kv4.2 channels was weaker for the JNCL-related missense mutant

285 To understand how menthol activates the channel, we docked menthol to the channel and systematic

286 of hydrophilic and hydrophobic areas in the channels, we improve the extraction efficiency of magnet

287 Here we report that Kv11.1 channels were abundantly expressed in the large pulmonar

288 hy lung tissues from humans and rats, Kv11.1 channels were confined to the large PAs.

289 iral gene transfer, wild-type and mutant SK2 channels were overexpressed in adult rat VMs, revealing

290 gene encoding TRPM3, a calcium permeable ion channel, were identified as the cause of DEE in eight pr

291 s regulatory protein, TrkA, which closes the channel when bound to ADP and opens it when bound to ATP

292 This study investigates the role of TRPV4 channels, which are transmembrane calcium channels that

293 lts suggest that LINGO1 is a regulator of BK channels, which causes a "functional knockdown" of these

294 eighbor activation of energy-dissipating ion channels, while hydrogen peroxide distributes oxidative

295 induces the opening of a nonselective cation channel; while repeated or prolonged exposure induces fo

296 n cells by controlling an interaction of the channel with a peripheral membrane-associated Ca(2+)-bin

297 at blocks the extracellular vestibule of the channel with an IC(50) of 72 nM and greater than 200-fol

298 ifferent radiant powers, by using engineered channels with different temperature thresholds.

299 realization involves the integration of ion channels with newly designed gating properties into card

300 entiated the fentanyl-mediated block of hERG channels, with an IC(50) at pH 8.4 being 7-fold lower th