ライフサイエンスコーパス: channel gating

1 cilitated studies of the structural basis of channel gating.

2 late Galphaq/PLCbeta1/PKC activity to induce channel gating.

3 y to induce PKC phosphorylation of TRPC1 and channel gating.

4 ch is responsible for proton selectivity and channel gating.

5 nding to the VAMP721 SNARE domain suppressed channel gating.

6 ular loop D domain, a region involved in AQP channel gating.

7 trigger that is necessary and sufficient for channel gating.

8 driving force for calcium entry and calcium channel gating.

9 el activity by an allosteric modification of channel gating.

10 ity is responsible for driving PKC-dependent channel gating.

11 a Markov chain 36-state model (MC36SM) of GJ channel gating.

12 nction in terms of protein processing and/or channel gating.

13 hanisms of blocker-induced modulation of ion channel gating.

14 s in the M3 transmembrane domain involved in channel gating.

15 hat is crucial for protein translocation and channel gating.

16 1 complexes that lead to PKC stimulation and channel gating.

17 and were associated with alterations in K(+) channel gating.

18 ferent cyclic nucleotides on the CNBD and on channel gating.

19 plied to real-time structural studies of ion channel gating.

20 main (LBD), which is incapable of triggering channel gating.

21 differential effects of blocker molecules on channel gating.

22 cal ligand binding to the pore domain during channel gating.

23 bind to TRPV1 with high affinity to modulate channel gating.

24 how small molecules inhibit or activate ion channel gating.

25 and that the Ala1632Gly mutation may affect channel gating.

26 ains via interactions with CL1 and result in channel gating.

27 troke of the action potential (AP) due to GJ channel gating.

28 specific genetic perturbations to potassium channel gating.

29 acy, ATP more strongly stimulated ovine CFTR channel gating.

30 the NH2-terminal region is not essential for channel gating.

31 t contribute to narrowing of the pore during channel gating.

32 us provides a model of how cAMP controls HCN channel gating.

33 e principles underlying active transport and channel gating.

34 nformational and structural dynamics of CRAC channel gating.

35 that plays a role in subunit association and channel gating.

36 -venom peptide that allosterically modulates channel gating.

37 with enhanced conductance and ATP-dependent channel gating.

38 and the potential role of pore hydration in channel gating.

39 is required predominantly for its effects on channel gating.

40 ential connection between ion conduction and channel gating.

41 oltage- and cAMP-dependent mechanisms of HCN channel gating.

42 igates the effect of phosphatidic acid on Kv channel gating.

43 M3 helices that, in turn, are coupled to ion channel gating.

44 ater insight into the role of the CTD in Kir channel gating.

45 nker) to identify structural determinants of channel gating.

46 their conformational rearrangements dictate channel gating.

47 C) motifs, in the cholesterol sensitivity of channel gating.

48 the membrane but rather to an alteration in channel gating.

49 affected by the inherent variability of ion channel gating.

50 toskeletal proteins in mechanosensitive (MS) channel gating.

51 implicating the STIM1-dependent movement in channel gating.

52 mutations have been associated with altered channel gating.

53 P1 involves loop D, a region associated with channel gating.

54 DPA with the inherent voltage dependence of channel gating.

55 utative pre-M1 cuff helix that may influence channel gating.

56 these barriers can be regulated to simulate channel gating.

57 tage- nor use-dependent, and does not affect channel gating.

58 cAMP, the flavonoid fisetin potentiates HCN2 channel gating.

59 nit and is essential for rapid and efficient channel gating.

60 significant structural rearrangement during channel gating.

61 ed to generate high PIP2 sensitivity of Kir2 channel gating.

62 lpy (DeltaH(o)) and entropy (DeltaS(o)) upon channel gating.

63 l domains whose global properties can modify channel gating.

64 chieved within the tetrameric channel during channel gating.

65 the membrane allosterically regulating ANO1 channel gating.

66 teins may exert remote allosteric control of channel gating.

67 al calcium uptake 1 and 2 (MICU1/2) to alter channel gating.

68 2 of the accessory SUR1 subunit of K(ATP) in channel gating.

69 k ATP-induced SUR1 conformational changes to channel gating.

70 ing and following IP(3) binding that lead to channel gating.

71 loss of constraints on TrkH are required for channel gating.

72 and binding in Cys-loop receptors relates to channel gating.

73 f Gbetagamma, but has not been implicated in channel gating.

74 iments alone, such as ion conduction and ion channel gating.

75 cell malfunction derives from altered Cav1.2 channel gating.

76 w neurotransmitter binding is coupled to ion channel gating.

77 rocesses and second messengers alter TMEM16A channel gating.

78 he Orai N terminus is indispensable for Orai channel gating.

79 the pathways that couple agonist binding to channel gating.

80 shown to antagonize NsVBa without affecting channel gating.

81 tage-dependent structural changes related to channel gating.

82 ric and allosteric mechanisms regulating its channel gating.

83 cluster near pore constrictions and regulate channel gating.

84 rrounding bilayer, were actively involved in channel gating.

85 in is organized as a tether that can trigger channel gating.

86 wo ATP sites reveals their distinct roles in channel gating.

87 s by NUDT9, but nevertheless supported TRPM2 channel gating, albeit with reduced apparent affinity.

88 R and GLIC, does not undergo agonist-induced channel gating, although it does not exhibit the expecte

89 o indicates that the lipid bilayer modulates channel gating, although it is not clear how.

90 We address this issue using detailed single-channel gating analysis, mathematical modeling, and ener

91 ees C to study the physiological kinetics of channel gating and action potentials.

92 sly thought to be the target of PKC promotes channel gating and acts as an allosteric modulator of PK

93 Channel gating and adaptation, the ability of the bundle

94 Our findings suggest a model for CaV1.2 channel gating and Ca(2+)-influx amplification that unif

95 tiple discrete open states, each with unique channel gating and conductance properties that reflect c

96 lecular features in Orai1 that contribute to channel gating and consider how they give rise to the un

97 Inactivation is a complex aspect of Nav channel gating and consists of fast and slow components,

98 ell-free membrane patches and showed altered channel gating and current flow through open channels.

99 movement of the helix bundle crossing during channel gating and demonstrate how this method might be

100 tly to the Nav1.6 channel C-tail, regulating channel gating and expression, properties that are requi

101 Moreover, flecainide did not alter RyR2 channel gating and had negligible effect on the mechanis

102 ding the molecular mechanisms underlying the channel gating and inhibition of PANX1 and related large

103 G4934 and -G4941 in the pore-lining helix in channel gating and ion permeation was probed by replacin

104 we investigated the molecular mechanisms of channel gating and ion permeation.

105 ata explain the close coupling between ORAI1 channel gating and ion selectivity, and open a new avenu

106 o explains the dynamic coupling between CRAC channel gating and ion selectivity.

107 l can serve as a tool for the studying of GJ channel gating and its effects on the spread of excitati

108 on, the presence of mutant Cx26 shifted Cx43 channel gating and kinetics toward a more Cx26-like beha

109 nal states revealing the structural basis of channel gating and ligand-dependent activation.

110 into the mechanistic understanding of TMEM16 channel gating and lipid-dependent regulation.

111 ations in the intrinsic ligand affected hERG channel gating and LQTS mutations abolished hERG current

112 However, the molecular mechanism of TRAAK channel gating and mechanosensitivity is unknown.

113 ion with STIM1 and couple STIM1 binding with channel gating and modulation of ion selectivity.

114 lobal conformational changes underlying GlyR channel gating and modulation.

115 ctances to understand the interdependence of channel gating and permeation in the context of such res

116 dynamics simulations that shed light on Orai channel gating and permeation.

117 Our study provides insights into features of channel gating and proton permeation pathway.

118 rnal pore in the allosteric control of TRPV1 channel gating and provide essential constraints for und

119 ever, little is known about the mechanism of channel gating and regulation of ANO1 activity.

120 , we examined the effects of A760G on CaV1.3 channel gating and regulation.

121 m of temperature-dependent regulation of ion channel gating and shed light on ancient origins of temp

122 )(+) channels in ways that oppose defects in channel gating and synaptic transmission resulting from

123 malfunction derives from the altered Cav1.2 channel gating and that dihydropyridines are potential t

124 linker is a critical constituent of TRPC4/C5 channel gating and that disturbance of its sequence allo

125 and nonelectrophiles are important in hTRPA1 channel gating and that targeting chemical interaction s

126 y and play distinct roles in controlling ion channel gating and trafficking of AMPAR.

127 provide insights into the molecular basis of channel gating and will facilitate organism-specific dru

128 for investigating beta-cell physiology, KATP channel gating, and a new chemical scaffold for developi

129 s in hair-bundle mechanics, mechanical load, channel gating, and adaptation may allow a hair bundle t

130 acilitate stomatal movements, the effects on channel gating, and by inference on K(+) accumulation, c

131 For example, phosphorylation regulates Nav channel gating, and has been proposed to contribute to a

132 n of TM6, which plays a crucial role in ANO1 channel gating, and increases the accessibility of the i

133 stinct transitions, independently coupled to channel gating, and that (2) TRPV1 and Ca(2+)-bound CaM

134 igher in smokers, blocked CFTR by inhibiting channel gating, and was attenuated by antioxidant N-acet

135 This mode of operation and its impact on channel gating are confirmed by computational and experi

136 nisms whereby chemical ligands impact on TRP channel gating are poorly understood.

137 However, the mechanisms that control channel gating are unclear.

138 ectively disrupts adenylate kinase-dependent channel gating at physiologic nucleotide concentrations.

139 Here, we compared single-channel gating behavior of two natural Ca(V)1.3 splice i

140 ated the effects of Rg3 on voltage-dependent channel gating but did not prevent the increase in curre

141 pproaches--an ATP analog that can drive CFTR channel gating but is unsuitable for phosphotransfer by

142 able to trigger Ca(2+)-dependent feedback of channel gating but may support alternate regulatory func

143 PAS and CNBh domains participate in channel gating, but at least twice in evolutionary histo

144 Glycine 4864 is not absolutely required for channel gating, but some flexibility at this point in th

145 eta-, and -subunits also suppresses apparent channel gating, but the suppression is much greater in t

146 ances binding to HCN channels and influences channel gating by altering the affinity of TRIP8b for th

147 s in the TRP domain raised the energetics of channel gating by altering the coupling of stimuli sensi

148 olenoid scaffold, suggesting a mechanism for channel gating by Ca(2+).

149 the channel pore, suggesting a mechanism for channel gating by internal stimuli.

150 cular mechanism for allosteric regulation of channel gating by intracellular signals.

151 Ca(2+)-CaM perform the same function on IKS channel gating by producing a left shift in the voltage

152 Gly-4934 and Gly-4941, that facilitate RyR1 channel gating by providing S6 flexibility and minimizin

153 A749G and p.G407R caused dramatic changes in channel gating by shifting (~15 mV) the voltage dependen

154 open the channel indicating that cold drives channel gating by stabilizing the folded state of the CT

155 the 986-990 region had a profound impact on channel gating by voltage and menthol, as evidenced by t

156 tochastic simulation algorithm that includes channel gating, Ca(2+) buffering, and Ca(2+) diffusion.

157 resent in Cr-TRP1, suggesting that basic TRP channel gating characteristics evolved early in the hist

158 ow, in an insect ear, that directionality of channel gating considerably sharpens the neuronal freque

159 TRPV1 C terminus with the bilayer modulates channel gating, consistent with phylogenetic data implic

160 he protein, only one of which contributes to channel-gating control.

161 2-M3 loop (A305V) that form the GABA binding/channel gating coupling junction and the channel pore (T

162 igating the effects of internal Ca(2+) on BK channel gating currents.

163 s itself in defective channel processing and channel gating defects.

164 at the interface produced marked effects on channel gating, demonstrating the important physiologica

165 lective pLGICs, and the modulatory effect on channel gating depends on the M2 18' residue.

166 ded detailed insights into the mechanisms of channel gating, desensitization, and ion permeation.

167 ently with SYP121, thereby coordinating K(+) channel gating during SNARE assembly and vesicle fusion.

168 re-lining transmembrane helix that underlies channel gating either directly or through the interface

169 Channel gating, especially of the dominant K(+) channels

170 he mechanisms involved in regulation of K(+) channel gating, expression and membrane localization.

171 ge in the coupling of temperature sensing to channel gating generates this sensitivity to warm temper

172 ophysical basis of temperature-sensitive ion channel gating has been a tough nut to crack.

173 Although TRPM8 channel gating has been characterized at the single chan

174 ular nicotinic acetylcholine receptor (AChR) channel gating have been measured by using single-channe

175 ested coupling of this enzymatic activity to channel gating implied a potentially irreversible gating

176 2E/K701R/S704T) was not sufficient to rescue channel gating, implying that other residues in the TRP

177 lying Gloeobacter violaceus ligand-gated ion channel gating in a membrane environment and report the

178 the Cys loop, a region that is critical for channel gating in all pentameric ligand-gated ion channe

179 release channels resulting in enhanced IP3R channel gating in an amyloid beta (Abeta) production-ind

180 el mutation had reduced impact on ovine CFTR channel gating in contrast to its marked effects on huma

181 re (DHF); however, the role of altered Na(+) channel gating in CRT remains unexplored.

182 To probe the role of channel gating in mammalian proteasomes, we deleted the

183 latform for transmission and coordination of channel gating in response to external K(+) .

184 ssociated with LQT3 promote a mode of sodium channel gating in which some channels fail to inactivate

185 creasing single-channel conductance, slowing channel gating, increasing calcium permeability, and rel

186 revertants had marked effects on G551D-CFTR channel gating, increasing strongly opening frequency, w

187 n the control of both surface expression and channel gating, indicating that this I-II loop plays an

188 annels and was unaffected by modification of channel gating induced by anemone toxin (rATX-II).

189 To investigate the stoichiometry of altered channel gating induced by RPR, we constructed and charac

190 presence of an osmoticant agent suggest that channel gating involves a change in solute-inaccessible

191 gs suggest that the allosteric modulation of channel gating involves distinct mechanisms of coupling

192 omain is critical for CFTR function, because channel gating involves NBD1/NBD2 dimerization, and NBD2

193 hat the specific heat capacity change during channel gating is a major determinant of thermosensitive

194 ELIC and the proton-activated GLIC, suggests channel gating is associated with rearrangements in thes

195 Because G551D-CFTR channel gating is ATP independent, we investigated wheth

196 n mechanism would reveal how STIM1-dependent channel gating is enhanced, and benefit the future immun

197 Ion channel gating is essential for cellular homeostasis and

198 ata describe a novel mechanism by which hERG channel gating is modulated through physiologically and

199 nts, so that voltage-dependent activation of channel gating is no longer conflated with Ca(2+) entry,

200 viously reported voltage-dependence of Panx1 channel gating is not directly mediated by the membrane

201 nical mechanistic model explaining potassium channel gating is of a conformational change that altern

202 und that the enthalpy change associated with channel gating is proportional to the length of the CTD.

203 Ca(2+)- and voltage-sensing mechanisms on BK channel gating is still debated.

204 CFTR channel gating is strictly coupled to phosphorylation an

205 Hence in GtCCR2, cation channel gating is tightly coupled to intramolecular prot

206 lar mechanism that links effector binding to channel gating is unknown due to lack of structural data

207 significance of the S6 cytoplasmic region in channel gating is unknown.

208 uctural mechanism coupling ligand binding to channel gating is unknown.

209 The molecular mechanism of channel gating is yet elusive.

210 In voltage-gated K(+) channels, gating is the result of the coordinated action

211 f the hydrophobicity of specific residues in channel gating, it has remained unclear whether electros

212 ith soluble chimeras retained ADPR-dependent channel gating (K1/2~1-5 muM), confirming functionality

213 speculate that modulation of tight junction channel gating kinetics may be an unappreciated mechanis

214 The detailed single-channel gating kinetics of mouse pannexin 1 (mPanx1) rem

215 sensitivity of the I (Ks) channel and shifts channel gating kinetics toward more negative potentials.

216 rom regulation of trafficking to shaping ion channel gating kinetics.

217 T9-H catalytic activity all failed to affect channel gating kinetics.

218 tageous to improve the optical resolution of channel gating kinetics.

219 This study proposes a unique channel gating mechanism and delivers detailed molecular

220 This particular anion channel gating mechanism predicts the existence of mutan

221 or investigating the structural basis of TRP channel gating mechanisms and pharmacology, and, despite

222 cryptophyte ACRs, indicating differences in channel gating mechanisms between the two ACR families.

223 ically bind and modulate MscL: insights into channel gating mechanisms.

224 For a multitude of channels, gating models suggested by paths within the co

225 fore concluded to represent the first sodium channel gating modifier from an araneomorph spider and f

226 We conclude that AMD is an effective hERG channel-gating modifier capable of lengthening the plate

227 determine the mechanism of action for sodium channel gating modifiers with high precision.

228 bilayer embody independent modules linked to channel gating modulation.

229 putations show that even without significant channel-gating motions, a subtle change in the number of

230 alter binding and secretion in parallel with channel gating, net K(+) concentration, osmotic content

231 that a number of mutations that affect TREK1 channel gating occlude the action of fenamates but only

232 t between triple-site ligand binding and the channel gating of human TRPM2.

233 cid analogue N-arachidonoyl taurine restores channel gating of many different mutant channels, even t

234 ow a non-linear dependence of T-type calcium channel gating on GABA(B) receptor activity regulates ne

235 l coupling through a fast mechanism, such as channel gating or membrane organization, while Epac2 reg

236 ent results from a distinctive form of Na(+) channel gating, originally identified in cerebellar Purk

237 ion of deflections that elicited significant channel gating, plummeted upon application of a channel

238 ng charges(1-3), the general determinants of channel gating polarity remain poorly understood(4).

239 Understanding plant K(+) channel gating poses several challenges, despite many si

240 enuates cell surface expression and apparent channel gating, predicting a reduced magnitude and an ac

241 Studies of channel gating present a significant challenge, as activ

242 hich electrical driving force is balanced by channel gating, prevents changes in calcium influx from

243 pore and demonstrate the existence of anion channel gating processes outside the EAAT uptake cycle.

244 involved in the dynamic regulation of Cav3.2 channel gating properties.

245 xpression of KATP channels without affecting channel gating properties.

246 ects of FKBP12 and FKBP12.6 on RyR1 and RyR2 channel gating provide scope for diversity of regulation

247 ptide, LS3, has a unique action, suppressing channel gating rather than blocking the pore of heterolo

248 s opposing, consequences on agonist binding, channel gating, receptor biogenesis, and forward traffic

249 We determined that although GJ channel gating reduces junctional current, it does not s

250 mponents that transduce bilayer tension into channel gating remains incomplete.

251 The mechanism of channel gating remains undefined.

252 how PKC and PI(4,5)P2 act together to induce channel gating remains unresolved.

253 An adequate model of channel gating requires accurate, high-resolution models

254 of response consistent with the rapidity of channel gating response to changes in the external ionic

255 Kinetic analysis of channel gating revealed that AITC acts by destabilizing

256 ch we faithfully reproduced by an allosteric channel gating scheme where the channel is able to open

257 were faithfully reproduced by an allosteric channel gating scheme.

258 How KCNE1 and KCNE3 subunits modify KCNQ1 channel gating so differently is largely unknown.

259 Glu-68 site (the E68R mutation) inverted the channel gating so that it was open in the dark and close

260 ict the behavior of fundamental variables of channel gating such as the macroscopic gating current, a

261 hich may be a general feature of beta-barrel channel gating, suggest either an entropy-driven gating

262 mplementary electrophysiological analysis of channel gating, suggests chemical interactions that are

263 tward movements and thus contributed more to channel gating than the GluN1 subunits.

264 here are previously unaccounted steps in EAG channel gating that could be activated by ligand binding

265 are classically studied as regulators of ion channel gating that engage the nAChR channel pore.

266 ed a stochastic 36-state model (S36SM) of GJ channel gating that is sensitive to transjunctional volt

267 cribe conformational changes associated with channel gating, the fluorescent non-canonical amino acid

268 a predominance of the GluN2A subunit in ion channel gating, the GluN2A subunit interacts more extens

269 tion where agonist binding is uncoupled from channel gating, the underlying mechanism remains to be d

270 vide a foundation to further understand TRPV channel gating, their divergent physiological functions,

271 al for STIM1, as it fine-tunes the open Orai channel gating, thereby establishing authentic CRAC chan

272 ur study aims to uncover novel insights into channel gating through in-depth structure-function analy

273 y or post-M4 region increase the efficacy of channel gating through interactions with the Cys loop.

274 t, and highlight the power of describing ion channel gating through the lens of allosteric coupling.

275 affect cone voltage-gated Ca2+ channel (CaV channel) gating through changes in pH.

276 nges in electrical driving force and calcium channel gating to cancel each other out.

277 calcium driving force and changes in calcium channel gating to effectively cancel each other out.

278 channel open probability, (2) a shift of MS channel gating to larger pressures, (3) appearance of mo

279 ng of the intracellular Ca(2+) signal to the channel gating to regulate membrane excitability and spi

280 including the potentiator ivacaftor, augment channel gating to restore 30-50% of CFTR-mediated anion

281 uations and a 36-state model of gap junction channel gating to simulate electrical signal transfer th

282 of the conformational change associated with channel gating to tip-link tension.

283 nd/or CFTR potentiators, drugs that increase channel gating, to reach approximately 25% of the chlori

284 at the S4-S5 linker plays a critical role in channel gating upon CBD binding.

285 frequency as well as chemical inhibitors on channel gating using a Ca(2+)-sensitive promoter to expr

286 on and inactivation of ion channels, and how channel gating varies with changes in the channels' lipi

287 s (CD-Is) of eukaryotic Kir channels control channel gating via stability of a novel inactivated clos

288 proton transfer reactions play a key role in channel gating, we determined vibrational as well as kin

289 the structural basis of CD-I control of Kir channel gating, we examined the effect of the R165A muta

290 Using an allosteric model of channel gating, we found that the underlying mechanism o

291 embrane are altered by pH and thereby affect channel gating, we measured patch capacitance during mec

292 ngements of TMHs within them responsible for channel gating, we perform cross-linking by bifunctional

293 Both intrinsic ATPase activity and CFTR channel gating were inhibited severely by CL1 peptide, s

294 We demonstrate that the channel gating, which acts on chordotonal stretch recept

295 ing flexibility in terms of the mechanism of channel gating, which allows KCNQ1 to play different phy

296 amino acid at Kir6.2 position 68 for normal channel gating, which is potentially necessary to locali

297 6 coupling through a fast mechanism, such as channel gating, while Epac2 regulates slower mechanisms

298 residue A110 to E118) dissociates during the channel gating, while the rest of the C-terminus stays a

299 subunits, and that probing the mechanisms of channel gating with concatenated heterotypic channels sh

300 the CF mutant G551D, which impairs severely channel gating without altering protein processing and w