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1 on involves widespread rearrangements of the channel protein.
2 interacts with the extracellular part of the channel protein.
3 ether-a-go-go related gene (hERG) potassium channel protein.
4 he regulatory sites are not intrinsic to the channel protein.
5 lding and biosynthetic maturation of the ion channel protein.
6 ic complex formed by PKD1L3 and TRPP3, a TRP channel protein.
7 llular distribution of STREX-containing BKCa channel protein.
8 t with the idea of recognizing a new site on channel protein.
9 ding of phosphoinositides to the full-length channel protein.
10 t of trafficking or surface targeting of the channel protein.
11 eptide of the influenza A M2 (AM2-TM) proton channel protein.
12 d conformational defect directly in the hERG channel protein.
13 se two ligands to extracellular sites of the channel protein.
14 g the tyrosine phosphorylation of the mutant channel protein.
15 sociated glycoprotein (RhAG), a putative gas channel protein.
16 ite for the Akt protein kinase on the Kv11.1 channel protein.
17 he decreased tyrosine phosphorylation of the channel protein.
18 is an intrinsically disordered region of the channel protein.
19 ty in tsA201 cells by phosphorylation of the channel protein.
20 with the negatively charged residues on the channel protein.
21 et of mutants with alterations in their MscK channel protein.
22 lated with a 62.8% (P<0.01) reduction in Na+ channel protein.
23 2 ionic current occurs by endocytosis of the channel protein.
24 igh-resolution structures of a single sodium channel protein.
25 ine and lysine residues within N-terminus of channel protein.
26 li that interact with different parts of the channel protein.
27 ial duration by directly binding to the HERG channel protein.
28 e autophagy depends on the Matrix 2 (M2) ion-channel protein.
29 e ion-channel electrical measurements of ion-channel proteins.
30 h any of the known prokaryotic or eukaryotic channel proteins.
31 ing and electric current measurements of ion channel proteins.
32 ic theories concerning direct effects on ion channel proteins.
33 nd lipid phosphates to activate or bind to M-channel proteins.
34 that PTPepsilon in the brain modulates these channel proteins.
35 potential canonical (TRPC) subfamily of ion channel proteins.
36 ere isolated for analysis of PSD95 and K(V)1 channel proteins.
37 for distinct beta-subunit regulation of ion channel proteins.
38 onal analysis of amino acid substitutions in channel proteins.
39 r recording the activity of incorporated ion channel proteins.
40 in Lotus japonicus that encode putative ion channel proteins.
41 ersity are the complex targeting patterns of channel proteins.
42 e a ubiquitous family of transmembrane water channel proteins.
43 cardiac contractile, Ca(2+)-handing, and ion channel proteins.
44 l properties of this important family of ion channel proteins.
45 Viroporins are small virus-encoded ion channel proteins.
46 ficant changes in expression of Gi/o or GIRK channel proteins.
47 ly inhibited IKr and cross reacted with hERG-channel proteins.
48 ediate family of calcium-activated potassium channel proteins.
49 ease in PKC-dependent phosphorylation of the channel proteins.
50 paradigm for the control of activity of FNT channel proteins.
51 er membrane do so through substrate-specific channels proteins.
53 ulation of voltage-dependent anion-selective channel protein 2 (Vdac2) and downregulation of parvalbu
54 We discover that the chloride intracellular channel protein 3 (CLIC3) is an abundant component of th
55 nd down-regulated the chloride intracellular channel protein 3 (CLIC3), which induces the recycling o
56 on channel voltage-dependent anion-selective channel protein 3 (VDAC3), and complement inhibitor CD55
57 ion of PKC with phorbol ester increased HERG channel protein abundance and K(+) current density in a
58 s in SCN5A mRNA abundance but reduced sodium channel protein abundance and peak sodium current amplit
60 iggers a conformational change in the M2 ion channel protein, altering membrane curvature and leading
61 cherichia coli, each subunit of the trimeric channel protein AmtB carries a hydrophobic pore for tran
62 um channel function, discovery of the sodium channel protein, analysis of its structure and function,
63 ve trafficking of OSM-9, a polymodal sensory channel protein and a functional homolog of TRPV1 or TRP
64 ues localized on neighboring segments of the channel protein and by ions present in the vestibules, w
66 conductance by attaching ferritin to an ion channel protein and then tugging the ferritin or heating
68 dual functions in epithelial physiology: as channel proteins and as differential regulators of cell-
69 oscale events, such as Ca(2)(+) binding to a channel protein, and macroscale phenomena, such as excit
70 or transferring a cDNA encoding an enzyme or channel protein, and targeting expression to one cell ty
73 ntified antibodies against myelin, potassium-channel proteins, and T-cell profiles that support an ad
74 autoantibody reactivity against the chloride-channel protein anoctamin 2 (ANO2) in MS cases compared
76 nce (CaCC), and constitutive knockout of the channel protein anoctamin-1 leads to loss of slow waves
77 sses the importance of the three brain water-channel proteins (AQP1, AQP4, AQP9) in brain physiology.
78 5'-flanking regions of genes coding for the channel proteins Aqp2, Aqp3, Scnn1b (ENaCbeta), and Scnn
79 IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) and the evidence that
80 ymer vesicles containing the bacterial water-channel protein Aquaporin Z (AqpZ) were investigated.
91 y collecting duct system including the water channel protein, Aquaporin-3 and the tight junction prot
96 uctance, Ca(2+)- and voltage-gated K(+) (BK) channel proteins are ubiquitously expressed in cell memb
97 e, and polarity, and that using single water channel proteins as representative models has led to an
98 soon taking their place alongside other ion channel proteins as therapeutically important drug targe
99 ithelial sodium channel and acid-sensing ion channel proteins, as well as sodium/hydrogen antiporters
101 ng a vectorially oriented voltage-gated K(+) channel protein at high in-plane density tethered to the
102 is site is located on the outside of the ion channel protein at the lipid interface where the cholest
103 ulum (ER) Ca(2+) sensor, and Orai1, the CRAC channel protein, at overlapping sites in the ER and plas
105 nes were dominated by the voltage-gated K(+) channel protein because of the high in-plane density.
106 se forces must inevitably originate from the channel protein, because in bulk water, which, by defini
107 tivation gate are spatially separated in the channel protein, but the mechanism by which Ca(2+) bindi
108 receptor potential channel (TRPC)1 and TRPC3 channel proteins by short hairpin RNA reduces the sensit
109 lar parasites, viruses also have evolved ion channel proteins, called viroporins, which disrupt norma
112 e, we report that the chloride intracellular channel proteins CLIC1 and CLIC4 participate in the regu
113 lear translocation of chloride intracellular channel protein CLIC4 is essential for its role in Ca(2+
114 r levels and focuses on the discovery of ion channel proteins coexpressed in the mechanoreceptors of
117 1) Is acute tolerance observed in a single channel protein complex within a lipid environment reduc
118 that normally separates juxtaparanodal K(+) channel protein complexes located beneath the myelin she
119 clustering, and/or maintenance of axonal Kv1 channel protein complexes, we immunoprecipitated Kv1.2 a
122 ptors (iGluRs), tetrameric, ligand-gated ion channel proteins comprised of three subfamilies, AMPA, k
123 n families, including the human gap junction channel protein connexin 26, the ATP binding cassette tr
125 uses a modified conformation in the purified channel protein consistent with a more open state in sol
126 nd involve new molecular determinants on the channel protein, consistent with the idea of recognizing
127 tibodies that selectively recognize Ca(V)1.2 channel proteins containing sequences encoded by either
131 MEC-10 belong to a large superfamily of ion channel proteins (DEG/ENaCs) that form nonvoltage-gated,
133 ted by HpUreI, a proton-gated inner membrane channel protein essential for gastric survival of H. pyl
136 ented by AtNIP5;1 and AtNIP6;1, which encode channel proteins expressed in roots and leaf nodes, resp
137 escent protein to the N or C terminus of the channel protein, expressed in transfected HEK 293 cells
138 osphate receptor and voltage-dependent anion channel protein expression and elevated the number of ER
139 tent of deficits in sensory encoding and ion channel protein expression by single mechanosensory neur
140 on abbreviation, secondary to functional ion channel protein expression changes (CaV1.2, NaV1.5, and
141 er, there was a significant increase in HCN2 channel protein expression with no change in HCN4 expres
146 ously uncharacterized member of the two-pore channel protein family, as a new voltage-gated Na(+) cha
149 sient receptor potential-vanilloid-5 (TRPV5) channel protein forms a six- transmembrane Ca(2+)-permea
150 test this hypothesis, we expressed P/Q-type channel protein fragments from two different human CT sp
152 the backbone structure to that of the parent channel protein from which it is derived, we compare add
153 Many SUR1 mutations prevent trafficking of channel proteins from the endoplasmic reticulum to the c
156 iators and expression of chemosensory cation channels, protein gene product 9.5 (PGP 9.5), and the ma
162 larization-activated cyclic nucleotide-gated channel proteins (HCN proteins) that form Ih channels, i
163 n in retina, that Thy1 complexes with an ion channel protein in any tissue, and that a GPI-anchored p
164 nt proteomics study has identified the TRPV2 channel protein in EE, suggesting that transient recepto
167 These findings show a decrease in Kv3.1b channel protein in SZ neocortex, a deficit that is resto
168 ced expression of small-conductance Kca (SK) channel protein in the BLA of socially isolated (SI) rat
170 aquaporin-4 (AQP4), the most abundant water channel protein in the CNS, which is highly concentrated
171 cluded volume of ions and side chains of the channel protein in the highly concentrated and charged (
172 s that selectively modulate the stability of channel protein in the membrane as an approach for treat
174 (MscL) belongs to a family of transmembrane channel proteins in bacteria and functions as a safety v
176 abeling has demonstrated the presence of NaF channel proteins in GP dendrites, but the quantitative e
178 pleiotropic effects on the expression of ion channel proteins in myocytes and profibrotic molecules i
181 amily did not reveal a role for any of these channel proteins in store-operated Ca2+ entry in HEK293
183 tula venom alter the activity of diverse ion channel proteins, including voltage, stretch, and ligand
184 nding, human ether-a-go-go-related potassium channel protein inhibition, and CYP3A4 (CYP = cytochrome
185 s in ion channels; however, genes within the channel protein interactome might also represent pathoge
188 n of Aquaporins (AQPs), a family of membrane channel proteins, involved in several body functions.
189 Defective forward trafficking of K(v)11.1 channel protein is an important factor in acquired and c
194 en anterograde and retrograde trafficking of channel proteins is vital in regulating steady-state cel
195 ib, which belongs to the aquaporin family of channel proteins, is required for endosome maturation in
196 To design antibiotics that target substrate-channel proteins, it is essential to first identify the
198 code for functional potassium ion-selective channel proteins (Kcv) that are considered responsible f
199 anced glycation end products, L-type calcium channels, protein kinase C, Rho-kinase, actin polymeriza
201 modulation of expression of their respective channel proteins (Kir2.1 and Na(V)1.5) within a macromol
202 IS complex to the proximal axon, and the AIS channel protein Kv7.3 regulates neuron excitability.
203 ata correlate with a similar reduction in BK channel protein levels and transcripts in the cortex and
204 termate controls, and alpha1C L-type calcium channel protein levels were significantly lower in PC-1
205 defects, including mutations and decrease of channel protein levels, have been linked to the developm
206 bility of re-entry and affected specific ion channel protein levels, whereas excitability was unalter
208 olerance can be an intrinsic property of the channel protein-lipid complex, and bilayer thickness pla
209 an important role in regulating receptor and channel protein localization within synapses and tight j
211 peractivation mutant of a mammalian DEG/ENaC channel protein, MDEG G430F, in murine kidney epithelial
212 e pore helices of the small mechanosensitive channel protein, MscS, to monitor conformational transit
213 nano solar cell containing the mycobacterial channel protein MspA has been successfully designed.
215 Importantly, the expression of the sodium channel protein NaV1.5 was altered in AV nodal cells of
219 1-3 and MCOLN1-3) are presumed to encode ion channel proteins of intracellular endosomes and lysosome
220 e P2X receptors are not related to other ion channel proteins of known structure, there is at present
222 e subcellular localization and the number of channel proteins on the cell surface membrane, which is
225 an represent a different conformation of the channel protein or a different number of bound ligands.
227 ults directly from oxygen deprivation on the channel protein or is mediated by intermediary proteins
228 ion, the ER Ca(2+) sensor STIM1 and the CRAC channel protein Orai1 redistribute to ER-plasma membrane
231 the STIM1 gating mechanism in the human CRAC channel protein, ORAI1, and identify V102, a residue loc
232 r, Stim1, and calcium release-activated Ca2+ channel protein, Orai1, and provide further support for
238 ational changes and (de)stabilisation of the channel protein, possibly as a platform for transmission
239 ation layer of various membranes and through channel proteins, problems that are at the core of cellu
241 osphorylation of Kv1.3, as well as increased channel protein-protein interactions with IR and postsyn
242 ensatory mechanisms acting on a reservoir of channels proteins regulated at the level of gene express
243 nsparency, however, the identity of specific channel proteins regulating calcium influx within the le
244 S800 and enhanced surface trafficking of the channel protein, resulting in increased I(DR)/Kv2.1 curr
245 osis (Mtb) mutant lacking the outer membrane channel protein Rv1698 accumulated 100-fold more Cu and
248 tion by direct interaction between lipid and channel protein sites has received increasing attention.
249 epresents the first member of a new class of channel proteins specific for mycolic acid-containing ou
253 vious studies on single representative water channel proteins suggest narrow channels conduct water,
254 n the pancreatic ATP-sensitive K(+) (K(ATP)) channel proteins sulfonylurea receptor 1 (SUR1) and Kir6
255 tor potential melastatin-like 7 (TRPM7) is a channel protein that also contains a regulatory serine-t
256 tracellular late endosomal and lysosomal ion channel protein that belongs to the mucolipin subfamily
257 f the SCN5A gene, encoding the Nav1.5 sodium channel protein that cosegregated with the arrhythmia ph
258 brane conductance regulator (CFTR) is an ion channel protein that is defective in individuals with cy
259 se experiments demonstrated that Rv1698 is a channel protein that is likely involved in transport pro
261 interactions of conductances carried by ion channel proteins that are homeostatically regulated to m
262 modify expression of genes encoding the ion channel proteins that contribute to the electrophysiolog
263 ily expansions for the major families of ion-channel proteins that drive nervous system function.
264 the structure as well as a repertoire of ion channel proteins that govern this complex conduction pat
267 Primary cilia contain specific receptors and channel proteins that sense the extracellular milieu.
268 tly linked to bioelectric signaling, via ion channel proteins that shape the gradients, downstream ge
269 erall production of a model mechanosensitive channel protein, the mechanosensitive channel of large c
270 Its inclusion in or exclusion from TRPM3 channel proteins therefore provides a mechanism for swit
271 l energy by interacting with the rest of the channel protein through a combination of non-covalent in
272 reatly impact the distribution of the BK(Ca) channel protein to dendritic spines and intrinsic firing
277 ly, the transient receptor potential calcium channel protein TRPC1 redistributed to raft fractions in
278 anonical transient receptor potential (TRPC) channel protein TRPC5, in addition to STIM1 and Orai1, a
279 e a unique role for the Ca(2+)-permeable ion channel protein TRPC6 as a regulator of glomerular ultra
282 ts lacking a channel protein or defective in channel protein turnover exhibited modest and varied eff
283 ane protein (JAMP) that links ER chaperones, channel proteins, ubiquitin ligases, and 26S proteasome
285 ism is to dynamically regulate production of channel protein via feedback that constrains relationshi
286 T421M, an S1 domain mutation in the Kv11.1 channel protein, was identified in a resuscitated patien
287 nels were significantly decreased, while SK2 channel proteins were increased in IC neurons of seizure
288 otassium-channel gene activity (KCNMB1), the channel protein, were powerfully attenuated in the Srf(C
289 urally similar to the PAS domains in non-ion channel proteins, where these domains frequently functio
290 ikely due to enhanced forward trafficking of channel proteins, whereas the extracellular action is du
291 2(P1018L), produces a missense change in the channel protein whereby proline 1018 (Pro(1018)) is repl
292 in the "viroporin" family of virus-coded ion channel proteins, which includes the influenza A virus (
293 In particular, EV-associated annexin calcium channelling proteins, which form a nucleational core wit
296 ow that the M. tuberculosis protein Rv3903c (channel protein with necrosis-inducing toxin, CpnT) cons
297 d from (1) a partially trafficking-deficient channel protein with reduced cell surface expression and
299 ed here highlight a functional role for this channel protein within neurons of the dorsal vagal nucle
300 urements of mRNA transcripts that encode ion channel proteins within motor neurons in the crustacean