ライフサイエンスコーパス: channel-forming

1 hey share a common structural motif, and are channel forming.

2 rogen and oxygen species via three different channels, forming: (1) nitrogen dioxide (NO2) and hydrox

3 at functions as a phospholipid translocation channel, forming a 20-A-thick doughnut embedded in the i

4 at PP2calpha binds directly to neuronal Ca2+ channels forming a functional protein complex in vivo.

5 fically with both PKCepsilon and N-type Ca2+ channels, forming a PKCepsilon-ENH-Ca2+ channel macromol

6 ip that has multiple vertical and horizontal channels, forming a three-dimensional separation system.

7 lters channel stability, as monitored by the channel forming ability and channel lifetime, and ion pe

8 in, would reveal differences in the relative channel forming ability of monomeric, oligomeric, and fi

9 of the molecule in solution aggregation and channel forming ability.

10 ral plasticity is a major determinant of its channel-forming ability.

11 ted that its cytotoxicity is mediated by its channel-forming ability.

12 ce protein with beta(3) integrin binding and channel forming activities.

13 Despite detectable differences in the channel-forming activities and cytotoxic properties of t

14 ouble bond, and yet both its apoptogenic and channel-forming activities are greatly reduced.

15 ese peptides exhibit antibiotic and membrane channel-forming activities.

16 Channel forming activity has been monitored by incorpora

17 (ii) At lower concentrations, where its channel forming activity is hardly evident, alpha-LT aug

18 ution aggregation with complete retention of channel forming activity were generated.

19 Thus, channel-forming activity does not seem to be either nece

20 showed according to lipid bilayer studies a channel-forming activity of 0.6 nanosiemens in 1 m KCl.

21 on in planar lipid bilayers, we examined the channel-forming activity of subfractions of Pseudomonas

22 membrane, protects the cell from the lethal, channel-forming activity of the bacteriocin, colicin E1.

23 hat ablate vacuolating activity and membrane channel-forming activity render VacA unable to induce cy

24 ing octameric PA possess enhanced stability, channel-forming activity, and macrophage cytotoxicity re

25 th other Bcl-2 family proteins known to have channel-forming activity, but its activity exhibits a no

26 The reconstituted gp15:gp16 complex lacks channel-forming activity, suggesting that the pore for D

27 amphiphilic, beta-sheet-rich structures with channel-forming activity.

28 ets of ethanol and genetic variations in the channel-forming alpha subunit have been nominally associ

29 glycosylation and surface expression of the channel-forming alpha subunits.

30 the activity of homomeric BKs consisting of channel-forming alpha subunits.

31 y 100-residue polypeptides with at least one channel-forming alpha-helical transmembrane (TM) domain.

32 serine residues emerging from the top of the channel-forming alpha-helix, suggesting that this is the

33 Complementary DNA coding for the channel-forming alpha-subunit of a large conductance Ca(

34 rat brain, which contain four transmembrane channel-forming alpha-subunits and four cytoplasmically-

35 Through direct interactions with channel-forming alpha1 subunits, beta subunits enhance e

36 RC2, completing the ring and the DNA-binding channel, forming an additional ATP hydrolysis site.

37 on that enhances constitutively active TRPC3 channels, forming an ultra-short substantia nigra pars c

38 nly associate with a small number of calcium channels, forming an unreliable single vesicle release s

39 e subfamily of proteins, which contains both channel-forming and adhesin molecules, is extremely high

40 ses of kainate receptors vary when different channel-forming and auxiliary subunits are co-expressed

41 detection of NADH and use of alamethicin, a channel-forming antibiotic that enables an unrestricted

42 DH to intact mitochondria via alamethicin, a channel-forming antibiotic.

43 urally occurring analogues of this family of channel-forming antibiotic.

44 The structure reveals a channel-forming architecture that could allow passage of

45 mily proteins display structural homology to channel-forming bacterial toxins, such as colicins, tran

46 Colicin Ia, a channel-forming bactericidal protein, uses the outer mem

47 membrane sequence for apoptosis induction by channel-forming Bcl-2 proteins.

48 t large exoproteins through highly conserved channel-forming beta-barrel proteins.

49 These proteins contain a highly conserved channel-forming C-terminal domain, which functions toget

50 N-terminal translocation (T) domain and its channel-forming C-terminal domain.

51 omains of the colicin: (i) the COOH-terminal channel-forming (C) domain with the highest thermal stab

52 hogenic mutation A116V greatly increases the channel-forming capability of moPrP.

53 PrP, providing a rationale for its increased channel-forming capability.

54 e effective harnessing of the remarkable ion channel-forming capacity of this prototypical small mole

55 containing G121R or S246L mutations retained channel-forming capacity.

56 we demonstrate that cholesterol action on BK channel-forming Cbv1 proteins is mediated by their cytos

57 dies in Xenopus oocytes that co-expressed BK channel-forming (cbv1) and accessory beta1 subunits clon

58 The ion-channel forming colicins A, B, E1, Ia, Ib and N all kill

59 Channel-forming colicins are bacterial toxins that spont

60 em for the bacteriocin and immunity genes of channel-forming colicins B and Ia to optimize production

61 ese data offer new insights into the toxin's channel-forming component and the intermolecular interac

62 translocation system are the heterotrimeric channel-forming component SecYEG and its binding partner

63 The toxin's channel-forming component, protective antigen (PA), olig

64 nning segments and is similar in sequence to channel-forming components of ABC transporters.

65 timates for the head-to-head GAsl dimer (the channel-forming conformation), which matches the hydroph

66 gene Neurobeachin, the neuronal gap junction channel-forming Connexins, and the electrical synapse sc

67 We focus on orthogonal channel-forming connexins, namely connexin 43 and connex

68 (70 kDa), and subsequently translocating its channel forming domain across the periplasmic space, whe

69 with full-length colicin Ia to show that the channel forming domain is initially positioned 150 A abo

70 The channel-forming domain has been localized to amino acid

71 tal motion of the closed state of colicin Ia channel-forming domain in membranes of different anionic

72 The channel-forming domain of colicin E1 is composed of a so

73 ter-soluble and membrane-bound states of the channel-forming domain of colicin Ia.

74 ne (Q) to an arginine (R) located within the channel-forming domain of the alpha-amino-3-hydroxy-5-me

75 s carrying a Ryr2 mutation in the C-terminal channel-forming domain showed an increased odds of nonsu

76 ensus amphipathic region" (CAR), a potential channel-forming domain that is found to be evolutionaril

77 y replacing amino acids within the predicted channel-forming domain with the corresponding amino acid

78 eparation of this highly hydrophobic minimal channel-forming domain.

79 binding domains but different transmembrane, channel forming domains.

80 in Ia and diphtheria toxin N-terminal to the channel-forming domains can be translocated across plana

81 The 10-helix channel-forming domains of colicins Ia and E1 are struct

82 Apolipoprotein L-I (APOL1) is a channel-forming effector of innate immunity.

83 We explored whether the putative channel-forming fifth and sixth alpha-helices of Bcl-2 a

84 specific sequence, or the chirality, of the channel-forming gA analogues.

85 Pannexin 1 (Panx1) is a channel-forming glycoprotein expressed in different cell

86 Pannexin1 (Panx1), a channel-forming glycoprotein is expressed in neonatal bu

87 The channel-forming glycoprotein PANX3 functions in cutaneou

88 (PANX1), a member of the pannexin family of channel-forming glycoproteins, regulates cellular proces

89 ions that are required for translocating the channel-forming helices across the lipid bilayer upon vo

90 ing pocket contains residues from 2 adjacent channel-forming helices.

91 ich in turn activate RNLs, a class of cation channel-forming immune receptors.

92 tly reported that a water channel, aquaporin-channel-forming integral protein of 28 kDa, is present i

93 In contrast to previous data for the channel-forming integral protein of 28kDa (CHIP28), the

94 The aquaporins are a family of 10 channel-forming, integral membrane proteins of approxima

95 All channel-forming isoforms of TRPP channels (polycystin-2,

96 the transcripts of alpha-DTX-sensitive, I(D) channel-forming K(V) 1.1, K(V) 1.2 and/or K(V) 1.6 alpha

97 lpha-dendrotoxin (alpha-DTX)-sensitive, I(D) channel-forming K(V) 1.1, K(V) 1.2 and/or K(V) 1.6 alpha

98 cement by a single I18'S substitution in the channel-forming M2 helix (EC50 = 979 +/- 88 muM).

99 and conformer heterogeneity of an important channel-forming membrane peptide.

100 The p7 protein is a small ion-channel-forming membrane polypeptide encoded by the hepa

101 ing key molecular features of the pathogen's channel-forming membrane proteins.

102 ontaining CYP proteins to the peripheral and channel-forming mitochondrial outer membrane translocase

103 ontaining CYP proteins to the peripheral and channel-forming mitochondrial outer membrane translocase

104 l ion channel design, only a small number of channel-forming molecules are currently available for ad

105 Three channel-forming molecules with varying alkyl chains were

106 hydroxyl, amino, and carboxyl groups of the channel-forming molecules; in particular, some hydroxyl

107 the many hydroxyl groups appended to the ion channel-forming natural product amphotericin B.

108 confirmed that megakaryocytes expressed open channel-forming NMDA receptors in vivo.

109 nit, where it could contribute to the proton-channel-forming part of the structure.

110 Crystals of an ion-channel-forming peptaibol peptide in a partial membrane

111 he putative transmembrane segment of the ion channel forming peptide NB from influenza B was synthesi

112 t of tension on dimerization kinetics of the channel-forming peptide gramicidin A.

113 e using semisynthetic derivatives of the ion-channel-forming peptide gramicidin A.

114 nel ion conductance through pores of the ion channel-forming peptide gramicidin A.

115 The effects of the channel-forming peptide gramicidin D (gD) on the conduct

116 tion of an anion selective pore, formed by a channel-forming peptide, has been hypothesized as a nove

117 partitioning of alamethicin, a voltage-gated channel-forming peptide, was measured as a function of t

118 cin is a helical 20-amino acid voltage-gated channel-forming peptide, which is known to exhibit segme

119 esolution atomic-level crystal structures of channel forming peptides, theory has become a powerful t

120 protein (MW approximately 30 kD) to the ion channel-forming peptides (MW approximately 2.5 kD) eithe

121 A number of channel-forming peptides derived from the second transme

122 riggering disruption of self-assembly of ion channel-forming peptides in planar lipid bilayers.

123 ride selectivity for the different assembled channel-forming peptides.

124 rotrudes into host cells and likely contacts channel-forming plant plasma membrane proteins.

125 The hydrophobic channel-forming polypeptide gramicidin adopts a left-han

126 d insertion mechanism proposed for other ion channel-forming polypeptides.

127 g sites, the neomycin binding sites, and the channel-forming portion of the Ca2+ release channel are

128 e polar Ser residues decrease the analogues' channel-forming potency by 3 orders of magnitude, indica

129 es form membrane-spanning channels, with the channel-forming potency of the Ala analogue being much l

130 rthermore, similar deletions for the related channel-forming proapoptotic Bax and Bak did not impair

131 es in the subunit conformational preference, channel-forming propensity, single channel conductance a

132 not identified any notable difference in the channel forming properties between Abeta(1-40) and Abeta

133 own to reversibly block the cation-selective channel-forming protective antigen (PA(63)) component of

134 Anthrax toxin, which is composed of a channel-forming protein and two substrate proteins, is a

135 xport across the outer membrane requires the channel-forming protein FhaC.

136 A single channel-forming protein is found in yeast, whereas highe

137 translocation channel, in which the primary channel-forming protein is SecY.

138 s believed to be based in an outer membrane, channel-forming protein known as VDAC (voltage-dependent

139 ve been identified in mammals, including the channel-forming protein MCU.

140 ant cells are also resistant to aerolysin, a channel-forming protein secreted by Aeromonas spp., whic

141 Connexins are gap junction channel-forming protein subunits.

142 toxin produced by Clostridium septicum is a channel-forming protein that is an important contributor

143 tors Tom20, Tom22, and Tom70 and the central channel-forming protein Tom40.

144 novel function for HPV16 E5 as an oligomeric channel-forming protein, placing it within the virus-enc

145 Mutations in Cx32, a gap-junction channel-forming protein, result in X-linked Charcot-Mari

146 nus as the pore-lining segment of this novel channel-forming protein.

147 ell interface, as a strong candidate for the channel-forming protein.

148 PKD proteins differ from known ion channel-forming proteins and are generally thought to ac

149 Two classes of channel-forming proteins in the eye lens, the water chan

150 The reconstitution of channel-forming proteins into planar lipid bilayers enab

151 ne contains a considerably larger variety of channel-forming proteins than assumed thus far.

152 receptor (nAChR) belongs to a family of five channel-forming proteins that regulate communication bet

153 n the heart whereas levels of mRNAs of other channel-forming proteins were not affected at all.

154 lens fibers contain two known intercellular channel-forming proteins, connexin50 (Cx50) and Cx46.

155 importance because loss of the gap junction channel-forming proteins, connexins Cx32 and Cx47, resul

156 that PKD subunits constitute a new class of channel-forming proteins, enriching our understanding of

157 at induce water permeability comparable with channel-forming proteins, such as aquaporins and gramici

158 onstrated that of all six sarcolemmal K(ATP) channel-forming proteins, SUR2A was probably the least e

159 annexin1 (Panx1) or Pannexin2 (Panx2) as the channel-forming proteins.

160 n RNAi screen of innexin genes, which encode channel-forming proteins.

161 SignificanceThe channel-forming proteusins are bacterial helical peptide

162 rried missense mutations within the NR2B ion channel-forming re-entrant loop (p.Asn615Ile, p.Val618Gl

163 developed to study the chemical reactions of channel-forming receptor proteins in the microsecond-to-

164 the middle-coupling domain (wc703), and the channel-forming region (ka901).

165 de chain is removed, implicating this as the channel-forming region.

166 residue to influence the positions of other channel-forming residues.

167 and tested to determine the plasticity of a channel-forming sequence and to define whether channel p

168 Currents mediated by BK channel-forming slo1 homotetramers are consistently inhi

169 is attributable to collaboration between the channel-forming small molecule and protein ion pumps.

170 an odorant binding subunit, OrX, and an ion channel forming subunit, Orco.

171 d that PKD1L3, a PKD protein, functions as a channel-forming subunit in an acid-sensing heteromeric c

172 5AF is homologous to the channel-forming subunit of GerA family receptors and is

173 BK steady-state activity solely requires the channel-forming subunit slo1 within a bare lipid environ

174 is composed of three proteins, a translocase channel-forming subunit, called protective antigen (PA),

175 RAC channel activity mediated by a different channel-forming subunit.

176 backbone folding pattern is retained in the channel-forming subunits and that the substitutions prim

177 Two channel-forming subunits encoded by KCNH2 (hERG 1a and 1

178 v1.3 encoded by CACNA1D are dominant calcium channel-forming subunits of L-type Voltage-dependent Ca(

179 and a very similar pattern was observed when channel-forming SUR1-Kir6.2-GFP was expressed on its own

180 nduces the expression of Claudin-2, a cation-channel-forming tight junction protein.

181 s into a direct association of Mgr2 with the channel-forming Tim23 subunit.

182 OM20, or TOM22 for translocation through the channel-forming TOM40 protein.

183 ups that likely enhances the rigidity of the channel-forming topologically complex molecules.

184 pC (outer membrane protein C), and bacterial channel-forming toxin alpha-hemolysin.

185 wo primate-specific apolipoproteins: the ion channel-forming toxin ApoL1 (apolipoprotein L1) and the

186 Aerolysin is a channel-forming toxin secreted by Aeromonas spp. that bi

187 Obstructing conductive pathways of the channel-forming toxins with targeted blockers is a promi

188 The three-dimensional structure of the channel-forming trans-membrane domain of virus protein "

189 ions have been carried out on bundles of the channel-forming transmembrane (TM) domain of the viral p

190 main (ATD), a ligand-binding domain (LBD), a channel-forming transmembrane domain (TMD), and a carbox

191 Here, we have identified a minimum channel-forming truncation of the TD, the "beltless" TD,

192 beta1 modulates the gating properties of the channel-forming type IIA alpha subunit, resulting in an

193 reoriented to the periplasmic leaflet by the channel-forming WzmWzt ABC transporter for ligation to t