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1  checkpoint arrest due to phosphorylation of checkpoint kinase 1.
2                                              Checkpoint kinases 1/2 and E2F1 induce expression of the
3 CX-5461 is associated with activation of the checkpoint kinases 1/2, an aberrant G2/M cell-cycle prog
4                      We have determined that checkpoint kinase 1 and 2 signaling is important for apo
5      The DATS treatment caused activation of checkpoint kinase 1 and checkpoint kinase 2, which are i
6 a-mutated (ATM), ATM and rad3-related (ATR), checkpoint kinases 1 and 2 (CHK1/2), and WEE1-like prote
7 rowth-arrest DNA damage-45 (GADD45), and the checkpoint kinases-1 and -2.
8 mber of downstream substrates, such as Chk1 (checkpoint kinase 1) and H2AX (histone 2A variant X).
9 nse pathway, such as ATM, ATR, histone H2AX, checkpoint kinase 1, and tumor suppressor p53.
10 I dose regimen of LY2606368, an inhibitor of checkpoint kinase 1, as monotherapy.
11 elangiectasia-mutated (ATM) and Rad3-related-checkpoint kinase 1 (ATR-CHK1)) is not activated in hTER
12  to carry germline RAD51 paralog D (RAD51D), checkpoint kinase 1 (CHEK1), breast cancer 2 (BRCA2), an
13 n of a number of cell cycle genes, including checkpoint kinase 1 (Chek1), which we identified as a hi
14 Zeneca compound collection was performed for checkpoint kinase-1 (Chk-1 kinase) using a knowledge-bas
15 ss led to defective ATR Ser/Thr kinase (ATR)/checkpoint kinase 1 (ChK1) activation and greater DNA da
16          We find that RPA is dispensable for checkpoint kinase 1 (Chk1) activation and that RPA direc
17 ) cell signalling network is activated, with checkpoint kinase 1 (Chk1) activation indicating prolong
18  of LRRK2 kinase domain surrogates, based on checkpoint kinase 1 (CHK1) and a CHK1 10-point mutant.
19  cells expressing apoptin with inhibitors of checkpoint kinase 1 (Chk1) and Chk2 causes apoptin to lo
20 sponses (DDRs) through its interactions with checkpoint kinase 1 (CHK1) and microcephalin (MCPH1).
21 regionally with increased phosphorylation of checkpoint kinase 1 (Chk1) and STAT3.
22                                Inhibitors of checkpoint kinase 1 (CHK1) are of current interest as po
23 ataxia telangiectasia and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) axis in a manner that was hig
24 elangiectasia mutated and Rad3-related (ATR)-checkpoint kinase 1 (Chk1) axis is the major signaling p
25 d through regulated degradation of activated checkpoint kinase 1 (Chk1) by this pathway after the gen
26 d on the crystallographic analysis of a urea-checkpoint kinase 1 (Chk1) complex and molecular modelin
27          In higher eukaryotic organisms, the checkpoint kinase 1 (Chk1) contributes essential functio
28 vealed that human Chk2 and a closely related checkpoint kinase 1 (Chk1) directly phosphorylate human
29 lated (ATR) kinase and its downstream target checkpoint kinase 1 (Chk1) facilitate survival of cells
30 eplication stress triggers the activation of Checkpoint Kinase 1 (Chk1) in a pathway that requires th
31           Although the essential function of checkpoint kinase 1 (Chk1) in DNA damage response has be
32             The functional roles of Cdc2 and checkpoint kinase 1 (Chk1) in synergistic interactions b
33 tivation of the DNA damage-associated enzyme checkpoint kinase 1 (Chk1) induced by pyrimidine depleti
34 of MK-8776 (SCH 900776), a potent, selective checkpoint kinase 1 (Chk1) inhibitor, as monotherapy and
35 The present studies sought to define whether checkpoint kinase 1 (CHK1) inhibitors and poly(ADP-ribos
36                      We have used two parent checkpoint kinase 1 (Chk1) inhibitors to exemplify the p
37 ave been synthesized as potent and selective checkpoint kinase 1 (Chk1) inhibitors via structure-base
38 onse of human multiple myeloma (MM) cells to checkpoint kinase 1 (Chk1) inhibitors.
39                      The DNA damage effector Checkpoint kinase 1 (Chk1) is a critical component of DN
40                                              Checkpoint kinase 1 (Chk1) is a key effector protein kin
41                                              Checkpoint kinase 1 (CHK1) is a key element in the DNA d
42                                              Checkpoint kinase 1 (Chk1) is a key element in the DNA-d
43                                              Checkpoint kinase 1 (CHK1) is a key mediator of the DNA
44                                              Checkpoint kinase 1 (Chk1) is a key regulator of checkpo
45                                          The checkpoint kinase 1 (Chk1) is an essential component of
46                                        Human checkpoint kinase 1 (Chk1) is an essential kinase requir
47                                              Checkpoint kinase 1 (CHK1) is an oncology target of sign
48 us work indicates that the checkpoint kinase Checkpoint kinase 1 (Chk1) is capable of phosphorylating
49                                              Checkpoint kinase 1 (CHK1) is critical for cell survival
50 report that depletion or acute inhibition of checkpoint kinase 1 (Chk1) is sufficient to restore gamm
51 diated by the ATM and Rad3-related (ATR) and checkpoint kinase 1 (CHK1) kinases to transiently suppre
52 h BRCA1-associated ring domain 1 (BARD1) and checkpoint kinase 1 (Chk1) levels.
53                                              Checkpoint kinase 1 (Chk1) mediates diverse cellular res
54 rogates for the LRRK2 kinase domain based on checkpoint kinase 1 (CHK1) mutants were designed, expres
55 ia telangiectasia and Rad3-related (ATR) and checkpoint kinase 1 (Chk1) pathway in p53-deficient cell
56 axia telangiectasia and rad3-related protein/checkpoint kinase 1 (CHK1) pathway inhibitors as cytotox
57 elangiectasia and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) pathway.
58 elangiectasia and Rad3-related protein (ATR)-checkpoint kinase 1 (Chk1) pathway.
59 owing that hydrogen peroxide (H2O2) triggers checkpoint kinase 1 (Chk1) phosphorylation in an ATR [at
60                                              Checkpoint kinase 1 (ChK1) plays a key role in the DNA d
61                                          The checkpoint kinase 1 (Chk1) preserves genome integrity wh
62                                Inhibition of checkpoint kinase 1 (CHK1) represents a potential therap
63 ed kinase (ATR)-dependent phosphorylation of checkpoint kinase 1 (Chk1) that is actuated in the absen
64 in loss of the G1 checkpoint and reliance on checkpoint kinase 1 (Chk1) to arrest cells in response t
65 e demonstrate that KRCC1 associates with the checkpoint kinase 1 (CHK1) upon DNA damage and regulates
66 ataxia telangiectasia and Rad3-related (ATR)/checkpoint kinase 1 (Chk1) via pyrimidine depletion.
67                                          The checkpoint kinase 1 (Chk1) was up-regulated and activate
68            Expression of ERH, ATR as well as checkpoint kinase 1 (CHK1) were higher in HCCs than in n
69                 In this study, we found that checkpoint kinase 1 (Chk1), a component of the G2 DNA da
70 actor intimately involved in this process is checkpoint kinase 1 (Chk1), a DNA damage repair inducing
71  (ATR) pathway, which prevents activation of checkpoint kinase 1 (Chk1), a key protein involved in co
72                                              Checkpoint kinase 1 (Chk1), a serine/threonine protein k
73        Embryos mutant for grp, which encodes Checkpoint kinase 1 (Chk1), are DNA-replication-checkpoi
74 teins including ATM, ATR (ATM-Rad3-related), checkpoint kinase 1 (CHK1), BRCA1, NBS1, and RAD51 by We
75 otein kinase, ataxia-telangiectasia mutated, checkpoint kinase 1 (CHK1), checkpoint kinase 2 (CHK2) a
76 ia mutated and Rad3-related kinase (ATR) and checkpoint kinase 1 (Chk1), leading to changes that bloc
77 Suppression of ATR, or its downstream target checkpoint kinase 1 (Chk1), selectively sensitizes DNA-d
78          Inhibition of a central ATR target, checkpoint kinase 1 (Chk1), through siRNA or a new and h
79                                              Checkpoint kinase 1 (CHK1), which is activated by DNA da
80 is induced by genotoxic stress in a p53- and Checkpoint kinase 1 (CHK1)-dependent manner.
81 a-telangiectasia and Rad3-related/cell-cycle checkpoint kinase 1 (CHK1)-mediated S-phase and G(2)-M-p
82 h prevents activation of its primary target, checkpoint kinase 1 (Chk1).
83 eckpoint activity through phosphorylation of checkpoint kinase 1 (Chk1).
84 , via phosphorylation, the key DDR regulator checkpoint kinase 1 (Chk1).
85 y when depleted, with loss of the cell cycle checkpoint kinase 1 (CHK1/CHEK1) being the most potent.
86  activity of virally induced AID resulted in checkpoint kinase-1 (chk1) phosphorylation and ultimatel
87  that, in the absence of induced DNA damage, checkpoint kinase-1 (CHK1), an enzyme essential for prev
88 spin, licensing the activation of the kinase checkpoint kinase-1 (CHK1).
89 inding motif of Rad18 is phosphorylated in a checkpoint kinase 1-dependent manner in genotoxin-treate
90  of the present study suggest existence of a checkpoint kinase 1-dependent mechanism for diallyl tris
91                Upon activation of the Grapes(checkpoint kinase 1) (Grp(Chk1))-dependent S-phase check
92 nown to phosphorylate Cdc25C on Ser216, both checkpoint kinase 1 (hChk1) and Cdc25C-associated protei
93 r (HGSOC) patients treated with a cell cycle checkpoint kinase 1 inhibitor (CHK1i), prexasertib.
94                                              Checkpoint kinase 1 inhibitors (CHK1is) sensitize most c
95 the increased sensitivity, we found that the checkpoint kinase 1 is destabilized in the absence of US
96 1 mutant that was proficient for ATR-induced checkpoint kinase 1 phosphorylation nevertheless conferr
97 ociated with elevated levels of IL-1beta and checkpoint kinase 1 phosphorylation.
98 ther demonstrated that USP37 deubiquitinates checkpoint kinase 1, promoting its stability.
99 , we found that despite robust activation of checkpoint kinase 1 signaling in RSR-deficient cancer ce
100 n of gemcitabine metabolites, and diminished checkpoint kinase 1, thereby sensitizing cells in the SN