ライフサイエンスコーパス: chelation

1 ed ferroptosis inhibitor, as well as by iron chelation.

2 s, NAD(+)-dependent dehydrogenation and iron chelation.

3 se (IN) and influenza endonuclease via metal chelation.

4 n conformational rearrangements enable Ca(2+)chelation.

5 n microscopy, which depolymerized after zinc chelation.

6 ntrol of a kinetic anomeric effect and metal chelation.

7 can be significantly improved without copper chelation.

8 on in JNCL cells could be reversed by Ca(2+) chelation.

9 kinase kinase (MEK) activity through copper chelation.

10 ron-rich media, failed to prosper under iron chelation.

11 ot causing toxicity related to serum calcium chelation.

12 erent approaches: click labeling and surface chelation.

13 eatments that may incorporate selective iron chelation.

14 reduction in cardiovascular events with EDTA chelation.

15 genous zinc application and enhanced by zinc chelation.

16 Ca(2+) channels prevented the effect of zinc chelation.

17 ER) Ca(2+) release versus cytoplasmic Ca(2+) chelation.

18 ll death were prevented by vitamin E or iron chelation.

19 e and include transfusions, splenectomy, and chelation.

20 sted P = .045) in children treated with DMSA chelation.

21 All-cause mortality was reduced by EDTA chelation (10% versus 16%; hazard ratio, 0.57; 95% CI, 0

22 ound carbonyl groups, thiol groups and metal chelation activities in addition to phenolic, total flav

23 CLE with copper chelation activity could inhibit PPO in a dose dependent

24 evaluated the effects of molecules with iron chelation activity on neuroblastoma (NB) cell lines.

25 pacity (TEAC), reducing power (RP) and metal chelation activity were used for all fractions.

26 ocytes was inhibited by intracellular Ca(2+) chelation, aggravated by thapsigargin, and unaffected by

27 Although intracellular calcium chelation almost completely blocked the induction of man

28 Mitochondrial iron chelation also alleviated CS-induced impairment of MCC,

29 Intracellular calcium chelation also inhibited EGF-induced activation of signa

30 acrocycle, although the pathway must involve chelation, amidation, macrocyclic ring reduction, lactam

31 tical for the sulfone-metal exchange because chelation anchors the organometallic proximal to the ele

32 orating structural components for both metal chelation and Abeta interaction.

33 Metal chelation and aromatic diacylation resulted in the most

34 ion, and is sensitive to postsynaptic Ca(2+) chelation and blockers of nicotinic receptors.

35 rognostic Scoring System), ranging from iron chelation and growth factors to lenalidomide and hypomet

36 iation-based therapies; nutritional therapy; chelation and heavy metal therapy; and biological and ph

37 ity and selectivity can be increased through chelation and here we theoretically explore the possibil

38 This chelation and its impact on the rate of polymerization a

39 in the same predictable manner controlled by chelation and negative hyperconjugation.

40 and tubules are disrupted by divalent cation chelation and restored by cation addition, including Zn(

41 The main step involved chelation and substrate-controlled diastereoselective re

42 ry, we present a non-toxic strategy for iron chelation and urinary elimination, based on manipulating

43 Structural data, confirming aldehyde chelation, and a proposed mechanism are provided.

44 ne modifications, including oxidation, metal chelation, and inhibitor binding, within a physiological

45 voltage-gated channels, is blocked by BAPTA chelation, and recruits intracellular calcium release on

46 mise of an individually tailored approach to chelation, and subsequent reduction in morbidity and mor

47 The surface chelation approach proved to be superior in terms of rad

48 transfusion, HCV treatment and adequate iron chelation are all tools to prevent HCC in thalassemia.

49 sms underlying the anticancer action of iron chelation are not fully understood.

50 est modulation of Dexras1 signaling and iron chelation are potential novel treatment strategies for o

51 Here, chelation as a mechanism to produce biodegradable elasto

52 humans, small studies have investigated iron chelation as a novel therapeutic strategy for prevention

53 Mechanistic experiments revealed iron chelation as a possible mode of action for PGG's activit

54 These findings further support Cu chelation as a therapeutic strategy to target oncogene-d

55 Calcium chelation, as well as the blockade of the mitochondrial

56 Calcium chelation assay determined the peptides to bind calcium

57 ir effects on the above factors, using metal chelation assays, antioxidant assays, and assays of Abet

58 N cross-coupling has been developed based on chelation-assisted amidation of readily available aryl b

59 The chelation-assisted C-C functionalizations proceeded with

60 al-catalyzed carbon-carbon bond formation by chelation-assisted C-H activation will be an attractive

61 This material is a rare example of chelation-assisted C-H functionalization performed by a

62 ith aryl isocyanates has been achieved via a chelation-assisted cationic ruthenium(II) complex cataly

63 Picolinate as a chelation-assisted leaving group could be activated by C

64 tation, we report here a palladium-catalyzed chelation-assisted ortho C-H bond olefination of phenyla

65 nitration of aromatic C(sp(2))-H bonds using chelation-assisted removable vicinal diamine directing g

66 9-methylamino-phenalen-1-one (4a), promoted chelation-assisted single electron transfer (SET) proces

67 In addition, metal chelation-based antibrowning ability of MRPs to inhibit

68 anism comprising the bidentate ligand-aided, chelation-based C-H functionalization was proposed for t

69 The versatility of chelation-based design has already shown promise in hydr

70 f colloidal nanoparticles involving strongly chelation between mercury ion and thiol(s) proved by con

71 the fluoride adduct confirms fluoride anion chelation between the two antimony centers.

72 odulin-kinase II expression, whereas calcium chelation blunted leptin-mediated increases in CYP11B2,

73 We report that, despite iron chelation, BT BM contains high levels of iron and ferrit

74 Iron chelation by excess Ent or Ybt significantly increased L

75 We show that iron chelation by FQ leads to epigenetic effects through inhi

76 bility of A. fumigatus to zinc and manganese chelation by neutrophil-derived calprotectin.

77 y for fluorescence emission on magnesium ion chelation by phosphorylated peptides carrying an artific

78 amendment of SCG could be related with their chelation by some SCG components, such as melanoidins an

79 the alpha-CNP chelate Mg(2+), mimicking the chelation by the beta- and gamma-phosphate oxygens of dN

80 hain is subject to oxidation, adduction, and chelation by thiol-reactive compounds.

81 The findings indicate that strong zinc chelation can promote gastric stability and impede intes

82 razilian and Uruguayan herbs had an 80% iron chelation capacity (p<0.001), while the iron chelation c

83 Finally, the correlation between the chelation capacity and ionophore activity is demonstrate

84 ffinity constant determined in SPR and metal chelation capacity determined from UV-visible spectropho

85 chelation capacity (p<0.001), while the iron chelation capacity of the Argentinean herb was lower but

86 In addition, zinc chelation causes a decrease in the expression of cytoske

87 tic compounds may also impart significant Pu chelation character to the colloid.

88 esented are detailed accounts of production, chelation chemistry, and biological use of selected main

89 Toward advancing understanding in Ac chelation chemistry, we have developed a method for char

90 lity of transferrin to chelate iron, as iron chelation combined with sodium bicarbonate completely pr

91 droxyl groups forming five- and six-membered chelation complexes with the iodine atom.

92 The chelation-controlled arylation reaction of chiral, enant

93 ctive reactions, including an intramolecular chelation-controlled Michael spirocyclization of an N-Cb

94 The key transformations rely on chelation-controlled organometallic additions and a Peta

95 The process couples a chelation-controlled reduction of the hydrazone with an

96 eaction, as only the E-isomers could undergo chelation-controlled reduction.

97 Our results suggest that DMG-mediated Ni-chelation could provide a novel approach to combat enter

98 Intracellular Ca(2+) chelation decreased VDCC mobility.

99 Twenty children aged </= 5 y who commenced chelation died during the period studied, with lead pois

100 Taking advantage of phosphine chelation, direct evidence for oxidative addition of Csp

101 s: primary extraction using a divalent metal chelation disk followed by anion-exchange chromatography

102 Moreover, we show that iron chelation disrupts mitochondrial homeostasis and trigger

103 nd continuous PLD assay that is based on the chelation-enhanced fluorescence property of 8-hydroxyqui

104 lation can occur within seconds after Ca(2+) chelation, especially if hair bundles are deflected towa

105 Iron chelation experiments demonstrate a relocation of the cl

106 rom dentate fast-spiking interneurones, zinc chelation facilitated T-type Ca(2+) currents, increased

107 although some patients may require intensive chelation for a limited duration.

108 review, we examine the existing data on iron chelation for AKI prevention in both animal models and h

109 Possible olefin or oxygen chelation from ring-opened CPE substituents was also obs

110 Pre-chelation geometric mean blood lead levels for children

111 solubilization by pectate lyase and calcium chelation greatly increased the indentation compliance w

112 The primary use of chelation has been transfusional iron overload.

113 , IC50 of 12.5 vs 30 muM for ADP, and Fe(II)-chelation, IC50 of 80 vs >200 muM for ADP (ferrozine ass

114 of PrOF NMR for efficiently analyzing metal chelation, identifying new binding modes, and studying p

115 sfusion-dependent thalassemia (TDT) and iron chelation impairs quality of life(1).

116 ot for Dsg3 was reduced after 24 h of Ca(2+) chelation in an ex vivo human skin model, suggesting tha

117 ng body of evidence for the benefits of iron chelation in myelodysplasia, pre-stem cell transplantati

118 l trials into the potential benefits of iron chelation in PD.

119 ell death and myelination is rescued by iron chelation in PMD pre-clinical models.

120 cle H2 macropa was investigated for (225) Ac chelation in targeted alpha therapy (TAT).

121 allenges of cancer, in nitrogen fixation and chelation, in the production of antibiotics, and in coll

122 Al(3+) chelation increased absorbance 2-42x and lambdamax great

123 DPPH scavenging and metal ion chelation increased significantly (p<0.05) from 29-40% t

124 of extracellular calcium leads to release of chelation-induced exosomes (CI-exosomes) from OVCAR-3 EO

125 Mechanistically, iron chelation-induced mTORC1 inhibition was not related to R

126 Bnip3 pathways partially contribute to iron chelation-induced mTORC1 inhibition.

127 udy of the safety and efficacy of EDTA-based chelation infusions in 1708 post-myocardial infarction (

128 Our findings indicate that iron chelation inhibits mTORC1 via multiple pathways and iron

129 performed to assess the importance of metal chelation (iron and copper) versus direct scavenging of

130 -1,9'-xanthen]-3(2H)-one (DEMAX) for Al(III) chelation is described herein.

131 stereochemical outcome of the reaction, and chelation is favored over the natural tendency of this t

132 neys and multiple other organs, whereas iron chelation is protective across a broad spectrum of insul

133 r data suggest that a pH increase and Ca(2+) chelation lead primarily to a loosening of contacts with

134 Removal of soluble metals by chelation markedly diminished the pulmonary PM-mediated

135 A chelation mechanism was initially proposed to explain th

136 pported adsorption steps including a citrate chelation method developed to remove >99.9% of the bariu

137 d (64)Cu labeling was obtained by a standard chelation method.

138 The thioenolate is found to bind via di-zinc chelation, mimicking the binding of intermediates in bet

139 We then find that pharmacological iron chelation mitigates the oligomerization of mutant CSPalp

140 dual-labeling approach with a multimodality chelation (MMC) scaffold would minimize steric effects o

141 mation for catalytic activity/efficiency and chelation mode in two organic transformations.

142 ive C-H activation was conducted without any chelation moieties.

143 ics of PSMA-11, radiolabeled on the basis of chelation of (18)F-AlF, with those of (68)Ga-PSMA-11 to

144 ing of NOTA to a unique cysteine residue and chelation of (18)F-AlF.

145 Elevation of [K(+) ](c) or chelation of [Ca(2+) ](c) linearizes the G(K(LV)) steady

146 Elevation of [K(+) ](c) or chelation of [Ca(2+) ](c) linearizes the G(K(LV)) steady

147 emilabile directing group which exploits the chelation of a readily removable benzyl ether moiety to

148 of the metallocavitand involved the initial chelation of a Ru(III) chloride complex by the tpy ligan

149 We successfully characterized the chelation of Ac(3+) by DOTP(8-) using EXAFS, NMR, and DF

150 Early chelation of blood-derived iron and antioxidant treatmen

151 the amnioserosa during closure, whereas the chelation of Ca(2+) slows closure.

152 is further stabilized by disulfide bonds and chelation of calcium ions.

153 by its cuprous oxidase activity but also by chelation of copper ions before they can enter the cytop

154 Histamine chelation of copper(I) by a terminal histidine residue i

155 Furthermore, chelation of cytoplasmic Ca(2+), but not inhibition of p

156 Instead, pharmacological depletion or chelation of Endoplasmic Reticulum (ER) Ca(2+) prevented

157 ola spatulata mechanotoxin 4 (GsMTx-4) or by chelation of extracellular Ca(2+) Thrombus formation was

158 slocation of NleF, which blocks caspase-4 or chelation of extracellular Ca2+, inhibited EPEC-induced

159 Here, we demonstrate that chelation of extracellular calcium leads to release of c

160 an brain cultures, miR-346 activity required chelation of Fe.

161 el inhibitor l-cis-diltiazem, as well as the chelation of intracellular Ca(2+) with BAPTA, or the abs

162 Removal of extracellular calcium, or chelation of intracellular calcium did not normalize the

163 expected to be associated with an increased chelation of intracellular cations, such as iron or calc

164 the compounds, CPX, were indeed dependent on chelation of intracellular iron and mediated by both G0/

165 Moreover, chelation of intracellular zinc alone was sufficient to

166 ETs in neutrophils, thus indicating that the chelation of iron may largely explain their inhibitory e

167 es fungi, which could be rescued by chemical chelation of iron.

168 Chelation of L1 with copper(II) provided assessment of l

169 ne that induces apoptosis in cancer cells by chelation of labile inhibitory zinc from procaspase-3.

170 procaspases to their active cleaved forms by chelation of labile zinc ions.

171 th the sieving mechanism of the membrane and chelation of lead with AG macromolecules incorporated in

172 he accumulation of Cd in grains, such as the chelation of light Cd isotopes by thiol-containing pepti

173 The effects of chelation of metal ions (Mg(2+), Al(3+), Cr(3+), Fe(3+),

174 ature hydroxamate moieties to facilitate the chelation of metal ions in the catalytic center of targe

175 idant ability in many food products, through chelation of metal ions, breakdown of radical chains and

176 Systematic investigation reveals that the chelation of metal ions, physical isolation of chelate c

177 Chelation of Na(+) leads to drastic decrease in the form

178 lavour stability: use of antioxidant crowns, chelation of pro-oxidants, and varying plant content in

179 Whereas in situ chelation of PyED leads to considerable degradation in t

180 Chelation of RBC degradation products with haptoglobin,

181 is216 were identified as essential for metal-chelation of sirohydrochlorin.

182 s has been synthesized and evaluated for the chelation of Th(4+).

183 uction of N2 under mild conditions, and then chelation of the alkali metal cation uncovers a highly r

184 0 consists of a monomer in which C,N and N,O chelation of the lithium cations generates a system cont

185 to be increased, probably due to compromised chelation of the metals in the stratum corneum of patien

186 DPPH and hydroxyl radicals, as well as metal chelation of the soluble fraction from PS, were higher t

187 s) (Mg(2+) or Mn(2+)) in its catalytic site: chelation of these metal cofactors is an attractive stra

188 A reduction of oxidative stress by chelation of toxic metals has been proposed as a possibl

189 In granule cells, chelation of zinc reduced the time window for the integr

190 g of the chip to yield a 3-D support for the chelation of Zn(2+) ions (ZnCl2) and the subsequent immo

191 Chelation of Zn(2+) with N,N,N',N'-tetra-2-picolylethyle

192 Chelation offers a unique advantage unseen in convention

193 Particularly, reports on the effects of iron chelation on mTOR complexes are inconsistent or controve

194 ta suggest the involvement of IP(6)-mediated chelation on Pontocerebellar Hypoplasia disease patholog

195 ating monomers and determining the effect of chelation on the polymerization mechanism.

196 ike and dissociated instantly following zinc chelation or a temperature decrease.

197 ificantly inhibited by intracellular Ca(2+)i chelation or CaM inhibition.

198 ption of these labile copper stores by acute chelation or genetic knockdown of the CTR1 (copper trans

199 Intracellular Ca(2+) chelation or overexpression of a Ca(2+)-insensitive CaM

200 Patients received 40 infusions of EDTA chelation or placebo.

201 Accordingly, iron chelation, or overexpression of a truncated AFT1 allele

202 ion was not related to ROS induction, copper chelation, or PP2A activation.

203 ression, was blocked by postsynaptic calcium chelation, our findings suggest that endogenous NT may a

204 okines studied significantly decreased after chelation (p < 0.001); TNF-alpha decreased from 371.6 +/

205 eatment-related difference (mean difference [chelation.placebo] during follow-up, 0.9 [95% confidence

206 mmune response to Ent and Lcn2 requires iron chelation rather than the Ent+Lcn2 complex itself and al

207 lements for Abeta aggregation control, metal chelation, reactive oxygen species (ROS) regulation, and

208 abilization (LMP) that relied on copper (Cu) chelation, reactive oxygen species generation, and incre

209 However, iron chelation reduced the oxidation rate.

210 Chelation reduced the primary composite end point of mor

211 tes and may provide an adjuvant treatment to chelation, reducing myocardial iron uptake.

212 /day or placebo in addition to their current chelation regimen.

213 Iron chelation rescued mutant oligodendrocyte apoptosis, surv

214 Dicarbonyl-to-arenium chelation rigidifies the reaction systems, so that remot

215 Aspergillus fumigatus and found that calcium chelation severely impedes hyphal growth indicating a cr

216 Chelation should be considered in patients with iron ove

217 the calcium signal by intracellular calcium chelation significantly reduced epidermal growth factor

218 cation (VO(+2)) through 4-carbonyl-5-hydroxy chelation site in the two luteolin molecule.

219 010) to 40 infusions ofa multicomponent EDTA chelation solution or placebo.

220 evaluated whether addition of amlodipine to chelation strategies would reduce myocardial iron overlo

221 referred to as "nutritional immunity." This chelation strategy ultimately starves invading pathogens

222 In addition, the zinc chelation strength of the polyphenols was also tested in

223 nvolves various mechanisms, among them metal chelation, studied by UV-visible spectrophotometry.

224 irohydrochlorin, the dehydrogenation product/chelation substrate; and a cobalt-sirohydrochlorin produ

225 le size regulation were eliminated by Ca(2+) chelation, suggesting a requirement for TRPML1-mediated

226 ch for individuals under chronic transfusion/chelation support therapy is allogeneic stem cell transp

227 consisting of diverse conjugation and metal chelation systems and imparting an array of colors to th

228 ted from the rabbit intestine using the Ca++ chelation technique.

229 ic affinity toward alumina through His(6)-Al chelation, TF2- and TF6-immobilized alumina-coated magne

230 to be a highly promising ligand for (225) Ac chelation that will facilitate the clinical development

231 After Pb(2+) chelation, the conjugation system of the PDA was perturb

232 After chelation, the mean LS significantly decreased from 5.4

233 with TDT over the age of 18 who were on iron-chelation therapy (ICT) were consecutively investigated.

234 overload correlated with lower compliance to chelation therapy (P<0.013).

235 Institutes of Health.funded Trial to Assess Chelation Therapy (TACT) randomized 1708 stablecoronary

236 The Trial to Assess Chelation Therapy (TACT) showed clinical benefit of an E

237 y reduced cardiac iron more effectively than chelation therapy alone.

238 the disease, which might impair an effective chelation therapy and lead to severe consequences due to

239 Iron chelation therapy can be effective in these MDS cases, b

240 aken together, these results suggest that Cu-chelation therapy could be repurposed to treat cancers c

241 The trial to assess chelation therapy demonstrated a significant (P=0.035) 1

242 with a history of myocardial infarction,EDTA chelation therapy did not have a detectable effect on QO

243 ients showing a positive response after iron chelation therapy displayed higher levels of PI-PLCbeta1

244 ient evidence to indicate the routine use of chelation therapy for all post-myocardial infarction pat

245 (n = 780) of dimercaptosuccinic acid (DMSA) chelation therapy found reduced blood lead levels in chi

246 Recent developments in gene and chelation therapy give hope of better prognosis for pati

247 EDTA chelation therapy has been in off-label use for the trea

248 Mitochondrial iron chelation therapy improved colitis and demonstrated an e

249 After institution of iron chelation therapy in 2010, no child with thalassemia maj

250 l capillary network for blood supply, copper chelation therapy may hold promise as an anti-cancer str

251 cardiac siderosis, amlodipine combined with chelation therapy reduced cardiac iron more effectively

252 I-PLCbeta1 quantification could predict iron chelation therapy response in MDS.

253 eposits was associated with lower anti-tumor chelation therapy response.

254 Targeted EDTA chelation therapy successfully reversed calcification in

255 suggest a molecular basis for exploiting Cu-chelation therapy to prevent autophagy signalling to lim

256 we tested a targeted nanoparticle-based EDTA chelation therapy to reverse CKD-associated MAC.

257 The trial to assess chelation therapy was a $30 million National Institutes

258 derate strength recommendation to begin iron chelation therapy when indicated.

259 Participants underwent chelation therapy with intravenous CaNa(2)EDTA for 2 day

260 nt haemoglobinopathies require lifelong iron chelation therapy with one of the three iron chelators (

261 ly positive results of TACT (Trial to Assess Chelation Therapy), and a body of epidemiological data s

262 ent primarily relies on transfusion and iron-chelation therapy, as well as splenectomy in specific ca

263 Despite chelation therapy, diffuse iron deposition was occurring

264 es an update on advances in the area of iron chelation therapy, including new indications and uses of

265 Eight patients had siderosis and underwent chelation therapy.

266 to 2012 after universal availability of iron chelation therapy.

267 a (IL-1beta), and interleukin-6 (IL-6) after chelation therapy.

268 t side effects associated with systemic EDTA chelation therapy.

269 last decade has ushered in a new era in iron chelation therapy.

270 matory mediators and glutathione (GSH) after chelation therapy.

271 .3 +/- 3.3 to 13.1 +/- 3.7 (p < 0.001) after chelation therapy.

272 CN2/SLC22A17 system and is inhibited by iron chelation therapy.

273 chelator currently in clinical use for iron chelation therapy.

274 ave been used to monitor patient response to chelation therapy.

275 nversion of terbium into a form suitable for chelation to targeting molecules in diagnostic nuclear m

276 Experimental evidence for polymer chelation to the Ru center is presented in support of a

277 WiTCH) trial compared standard (transfusions/chelation) to alternative (hydroxyurea/phlebotomy) treat

278 7,000 lead poisoned villagers, to facilitate chelation treatment of children </= 5 years old, and to

279 Chelation treatment was associated with increased levels

280 Any previous chelation treatment was permitted with a 7-day washout p

281 trations by 89%, and 2,349 children received chelation treatment.

282 y as feasible without sedation to tailor the chelation treatment.

283 onsidering the need for availability of more chelation treatments in paediatric populations, deferipr

284 )O(4)@Al(2)O(3) MNPs) were generated through chelation under microwave heating (power, 900 W) for 60

285 Fe3O4@Al2O3 MNPs through aluminum phosphate chelation under microwave heating within 1.5 min.

286 We examine the history of chelation up through the report of TACT.

287 mpared the effects of Cu(2+) application and chelation (using kainic acid, KA) on the neural retina f

288 expression, function, and mitochondrial iron chelation were assessed in a colitis-associated colon ca

289 idation-induced degradable nanogels for iron chelation were rationally designed by simultaneously pol

290 tion of each chain align, facilitating metal chelation when the residues are good ligands such as his

291 Current therapy is based on copper chelation, which decreases the manifestations of liver d

292 rt complex with Mn(II) with respect to trans-chelation with a metal ion such as Cu(II).

293 ion to be efficient, probably because of its chelation with cesium ion.

294 While early, presymptomatic detection and chelation with conventional copper-binding molecules ena

295 gulation of ALAS2, we evaluated whether iron chelation with deferiprone could decrease ALAS2 expressi

296 ET imaging and quantification of mAbs, after chelation with desferrioxamine B (DFO) and radiolabeling

297 Chelation with disodium calcium edetate lowers blood man

298 molysis and iron overload improved upon iron chelation with full correction of anemia in CEP mice tre

299 rize the mechanisms by which Ag(+) or Cd(2+) chelation with the Cys thiolates caused inhibition.

300 Chelation with three representative styrenes has been de