ライフサイエンスコーパス: chemical

1 from patients exposed to SN2-type alkylating chemicals.

2 sessment of these thyroid hormone disrupting chemicals.

3 ts host, which enhances light harvesting and chemical adsorption of CO(2) molecules dramatically, ach

4 onoxide-releasing molecules (photoCORMs) are chemical agents that allow for precise spatial and tempo

5 ther of toxicology Paracelsus (1493-1541) on chemical agents used as therapeutics, "the dose makes th

6 ts ought to be an important consideration in chemical alternatives assessment.

7 accumulates as part of a complex mixture of chemical analogs, termed taxoids, which complicates its

8 ctivity studies, in combination with quantum chemical analysis, suggest that the two carbon atoms of

9 ivariate statistics can be employed to guide chemical analysis, to improve de-replication, and to ide

10 olyte is directly visualized via advanced 3D chemical analysis.

11 This paper compares the results of standard chemical analytical processes and electrochemical impeda

12 for manufacturing materials and for sensing chemical and biological analytes.

13 ability, informing future utility of ETPs in chemical and biological studies.

14 vel selenium analogue of pheomelanin through chemical and biosynthetic routes using selenocystine as

15 water samples exhibited a high diversity of chemical and effect patterns, even for different rain ev

16 te the H(inact) state anaerobically via both chemical and electrochemical oxidation.

17 useful for studying the effects of genetic, chemical and environmental perturbations on biological s

18 Combined chemical and isotopic analysis of ceramic sherds (n = 12

19 chinery, and they are involved in converting chemical and light energy inputs into efficient mechanic

20 ant roles in pathogenicity, and their varied chemical and material properties make them suitable for

21 l within the MIEC channels suggests that the chemical and mechanical stability issues with the metal-

22 a vinyl ether double bond conferring special chemical and physical properties.

23 cumulations that are remarkably resistant to chemical and physical stresses.

24 s challenging because of the sheer number of chemicals and their ambiguous role in biodiversity-ecosy

25 ia protection from a wide range of physical, chemical, and biological stresses, support biofilms, and

26 timization and characterization of physical, chemical, and techno-functional properties of unmodified

27 e conditions, the presence of many different chemicals, and an electrical discharge.

28 tion of foamed PS exposes animals to harmful chemicals, and of greatest concern in this respect is th

29 clude an analysis of single-use instruments, chemicals, and products.

30 the transportation of equipment and process chemicals, and the ongoing effects of colonialism.

31 i, using an integrative crystallographic and chemical approach places quantitative constraints on mus

32 e we address this problem using an inorganic chemical approach, whereby multiple modes of protein-pro

33 Endocrine disrupting chemicals are common in our environment and act on hormo

34 ternal electrical bias, as well as precursor chemicals, are necessary.

35 rch of this SET, aimed at consolidating this chemical as a new green reagent that will be widely used

36 Yet, many current in vitro chemical assays to characterize antioxidant potential do

37 endocrine-disrupting potential of benchmark chemicals based on data generated from high content anal

38 ents will facilitate novel insights into the chemical basis of neurotransmission.

39 new and facile route and show a fascinating chemical behavior.

40 f cells filled with a switchable oscillating chemical (Belousov-Zhabotinsky) reaction.

41 ty as alternative electrophilic warheads for chemical biological probes and drug molecules is demonst

42 e past years, it has been used especially in chemical biology for peptide/protein synthesis, posttran

43 Here, a chemical-bonding framework is provided for understanding

44 Here, a strategy which uses chemical bonds as electron reservoirs is introduced to d

45 This study also examined unidentified chemical bonds in the polymer products, other than ester

46 sting that these species mediate adhesion by chemical bridging.

47 lows the user to ionize an extended range of chemicals by simple switching between DESI, voltage-free

48 g ESAA relief, were explored through quantum chemical calculations and experiments.

49 ce of DNA damage to the epithelium by UVR or chemical carcinogens.

50 The nanostructured morphology, chemical characteristics and electrochemical properties

51 ccessful in the evaluation of some important chemical characteristics but also brings flexibility, co

52 Morphological and chemical characteristics of synthesized materials will b

53 Chemical characterization and CAP phytoconstituent profi

54 the coupling of nanoparticle separation with chemical characterization bears potential to close this

55 Furthermore, we show an extensive chemical characterization of the LnPOM species present i

56 d Mucorales fungi, which could be rescued by chemical chelation of iron.

57 ail the development and optimization of this chemical cleavage acDrug PK assay, resulting in robust a

58 Chemical complementation of infected WT and CSE(-/-) mac

59 standing of the particle-level structure and chemical complexity.

60 arries extensive information on the detailed chemical components of food that is currently not integr

61 anical material properties together with the chemical composition and structure of both the cell wall

62 Overall, the chemical composition observed across various locations w

63 In this study, the chemical composition of leaves, flowers and stems of jam

64 drogen peroxide treatment altered the color, chemical composition, and techno-functional properties o

65 e particles have been designed by tuning the chemical composition, the size, the density, and the sur

66 f pH on the denaturation extent, the surface chemical composition, the water sorption isotherm and th

67 spectra are extremely sensitive to membrane chemical composition.

68 Quantifying chemical compositions around nanovoids is a fundamental

69 ough unraveling the profound relations among chemical compositions, mutual solubilities of constituen

70 heterogeneity are formed, by tuning complex chemical compositions.

71 ronic structure, interatomic potentials, and chemical compound space in chronological order.

72 The objective was to identify the chemical compounds that would typify each category.

73 ould be concluded that some of these unknown chemicals contained a sulfur atom attached to an arsenic

74 Biotransformation of chemical contaminants is of importance in various natura

75 ase matches because of informatic artifacts, chemical contaminants, and signal redundancies.

76 The improved chemical coverage by MALDI-2 can also help to improve ou

77 o directly target tau pre-mRNA in cells, via chemical cross-linking and isolation by pull-down target

78 embedded (FFPE) tissues requires reversal of chemical crosslinking and the removal of reagents that a

79 al results obtained using simulated and real chemical datasets.

80 ons: for example, by providing the host with chemical defenses.

81 Chemical depletion of cholesterol from HIV-1 particles i

82 Through strategic chemical derivatization, chiral chromatographic separati

83 Chemical design of multicomponent nanocrystals requires

84 ganic structures is of great interest in the chemical design of stimuli-responsive materials that mim

85 The model explains the trade-off among chemical design parameters such as the surface density o

86 environmental stressors and that exposure to chemical dispersants may pose a greater threat than oil

87 presented in this work seeks to preserve the chemical diversity displayed by heparin by allowing the

88 d demonstrates its versatility in generating chemical diversity for allosteric targeting of RORgammat

89 chains and of the modularity provided by the chemical diversity of monomers, to achieve uniform behav

90 pecialized metabolites constitute an immense chemical diversity, and play key roles in mediating ecol

91 ree of freedom can be actively controlled by chemical doping, interface modulation, and electrostatic

92 By tackling the intrinsic chemical/electrochemical issues, the proposed strategy p

93 With 15 chemical elements, the tool offers high flexibility in f

94 A classical battery converts chemical energy into a persistent voltage bias that can

95 tanding out for the continuous conversion of chemical energy into light.

96 re's solution to the efficient conversion of chemical energy to mechanical movement.

97 phthalocyanines (PC) that was cationized by chemical engineering.

98 s allowed the bacteria to strongly alter the chemical environment, causing on average more negative i

99 lei to act as reporters on their surrounding chemical environment.

100 Choosing hydrophobicity as an exemplary chemical environmental factor, we compared a range of es

101 )C values of the major fatty acids, provides chemical evidence for milk, meat, and plant processing b

102 r, we have provided genetic, structural, and chemical evidence that Gna1 is an antifungal target in A

103 engineered a protocol allowing for efficient chemical exchange for hundreds of C. elegans embryos sim

104 NMR relaxation dispersion, chemical exchange saturation transfer, and hydrogen-deut

105 The detected 290 chemicals explained only a small fraction (<8%) of the m

106 d hazard potential can be greatly altered by chemical exposure history and NP surface transformations

107 Considering the large number of physical and chemical factors involved in achieving fine control of L

108 In detail, we discuss chemical features of chimeric molecules and their use fo

109 eling studies provided new insights into the chemical features required for optimal interaction at th

110 is the electrochemical reduction of CO(2) to chemical feedstocks, which uses both CO(2) and renewable

111 to avoid this constraint, which resulted in chemical fingerprinting systems capable of recognizing u

112 rted when membrane fluidity is restored by a chemical fluidizer.

113 al step towards manufacturing petroleum-free chemicals from lignocellulosic biomass.

114 catalytic reduction of CO(2) (CO(2) RR) into chemical fuels is a promising route to enrich energy sup

115 this severe plant pathogen, and relative to chemical fungicides, provides broad benefits to the envi

116 We recently used CRISPRi/a-based chemical-genetic screens and cell biological, biochemica

117 Here we report ac(4)C-seq, a chemical genomic method for the transcriptome-wide quant

118 ique challenge for introducing electrophilic chemical groups.

119 Chemicals have improved our quality of life, but the res

120 S) research programs for drug development or chemical hazard assessment are designed to screen thousa

121 rpretations of our data sets, preserving the chemical heterogeneity uncovered by the single-cell anal

122 g the mechanism of action (MOA) of bioactive chemicals in terms of targeted signaling pathways is the

123 rming is environmentally crucial and for the chemical industry as well.

124 test suitable for point-of-need detection of chemicals inhibiting AChE.

125 Genetic deletion or chemical inhibition of AP-1 suppresses growth of YAP-dri

126 Importantly, genetic and chemical inhibition of beta-catenin-TCF/LEF signaling in

127 multiple lines of research that demonstrate chemical inhibition of cholesterol biosynthesis compromi

128 Inhibition of USP7 and USP10 by chemical inhibitors or knockdown had an additive effect

129 However, their chemical instability towards oxygen, light and heat limi

130 ced clinical turnaround times has influenced chemical instrumentation.

131 combination of a customized F-TD inlet with chemical ionization mass spectrometry (CIMS) and ultrape

132 Special attention is given to the soft chemical ionization method known as selected ion flow tu

133 Fermentation as a production method for chemicals is especially attractive, as it is based on ch

134 tion of QET-MS to the study of heterogeneous chemical kinetics with the reaction of gas phase O(3) an

135 ore, in silico tools were used to expand our chemical knowledge of compounds observed in superfood sa

136 or di-n-butyl-phthalate (DBP, a plasticising chemical known to induce testicular dysgenesis in vivo i

137 x network behavior in DCvNs emerges from the chemical landscape of the dynamic chemistry at the junct

138 based probes (Ub-ABPs) employing solid phase chemical ligation (SPCL).

139 Our results provide a chemical link between the Hofmeister series and the cell

140 ions impacts the performance and outcomes of chemical machine learning methods.

141 biology is to improve the sustainability of chemical manufacturing.

142 n mass spectrometry approach, a selection of chemical markers related to the geographical origin of d

143 Thus, without inherent physical or chemical meaning or constraints, they are prone to biase

144 ybean meal extracts obtained by conventional chemical method were compared to those obtained by using

145 ations, which concerns novel monomer design, chemical methodology/strategy establishment, and a roadm

146 in the lung, the large spatial gradients of chemical mixing state may significantly influence the he

147 ial variability in number, size, source, and chemical mixing state of individual particles in a popul

148 Research on the health effects of chemical mixtures has focused mainly on early life rathe

149 t the VidaL system as a tool for the precise chemical modification of cellular proteins with spatial

150 The field of chemical modification of proteins has been dominated by

151 e detection that, in many instances, involve chemical modification of samples prior to analysis.

152 time also allow for resynthesis and adaptive chemical modification of the glycocalyx.

153 Here, we have used the chemical modification of Trp9, site-directed mutagenesis

154 -nucleic acid targets, ease of synthesis and chemical modification, amenability to be interfaced with

155 orms, focusing on key approaches - including chemical modification, bioconjugation and the use of nan

156 essing the encased DNA strands difficult, or chemical modification, such as covalent crosslinking of

157 molecular analysis due to fragmentation and chemical modification.

158 as well as additional post-translational and chemical modifications could also be simultaneously dete

159 Chemical modifications have myriad advantages over other

160 The optimized chemical modifications of adenine base editor mRNA and g

161 Moreover, we show that chemical modifications on fungal oxyluciferin can affect

162 ine), which combines structure probing using chemical modifications with direct long-read RNA sequenc

163 We review techniques such as mutagenesis, chemical modifications, and optogenetics that have been

164 Like the chemical nature of the hormones themselves, the signalin

165 ission studies were carried out to probe the chemical nature of the insulating ground state of VO(2),

166 the final stage of TPP biosynthesis and the chemical nature of the substrates that are translocated

167 (GWG5%) g/L as the steeping solution on the chemical, nutritional, and microbial quality of wheat gr

168 tively builds a structured representation of chemical odour space that highlights odour relationships

169 Automated chemical oligosaccharide synthesis is an attractive conc

170 presents promising routes for tailoring the chemical, optical, electronic, or mechanical properties

171 of modifying their activity through rational chemical or genetic approaches.

172 ental stressors such as treatment with heat, chemicals, or virus elicitors of UPR.

173 Fifteen stable novel phases with in-plane chemical ordering are identified, coined i-MAB, along wi

174 The chemical origin of this distinction was probed via fluor

175 articularly from wastewater streams with low chemical oxygen demand (COD) to nitrogen (C/N) ratios.

176 Chemical perturbation experiments suggest that mechanica

177 study microbiome-host interactions following chemical perturbations.

178 Chemical pollution has been mentioned as one of the plan

179 nd a positive dependence of the rate on H(2) chemical potential in decalin indicate that addition of

180 he in-plane magnetic field dependence of the chemical potential near filling factor one reveals a lar

181 s disrupted at both high and low extremes of chemical potential.

182 Here, we show that the chemical potentials of chalcogenide materials near the e

183 mize hit or lead compounds into high-quality chemical probes or drug candidates is an ongoing challen

184 he resulting oxazonine collection identified chemical probes that regulate mitochondrial membrane pot

185 This complex and highly dynamical chemical process involves assembly and disassembly of ma

186 on, as well as for use in consumer products, chemical processes and therapeutics.

187 rownian escape is key to a wealth of physico-chemical processes, including polymer folding and inform

188 e chemistry, green chemistry, and industrial chemical processes.

189 Herein, we present a programmable chemical processor comprising of a 5 by 5 array of cells

190 this field with a special focus on scalable chemical production using enzymes.

191 nt activity by six methods and determine the chemical profile of the pitomba fruit peel and pulp by e

192 e agricultural practices on the raspberries' chemical profile was dependent on the cultivar and canno

193 provides a great variability in its physical-chemical properties and is a basis for its broad success

194 The unique physical and chemical properties of fullerenes have offered new oppor

195 We identified the chemical properties of the aggregation pheromone that si

196 evaluated for their influence on oil yield, chemical properties, carotenoid and chlorophyll contents

197 tine-which also targets 2C-but has favorable chemical properties.

198 The chemical proteomic discovery of alpha-chloroacetamide (a

199 Here, we present a time-resolved chemical proteomic strategy to track the early-stage ent

200 and activity-based protein profiling (ABPP) chemical proteomics to identify the protein targets of t

201 The interfacial chemical reaction between nylon and MAHgEO greatly impro

202 r which converts standard representations of chemical reaction networks and circuits into hardware co

203 With this work, we built a database of chemical reaction relationships from almost 900,000 scie

204 ons to correlate conformational changes with chemical reaction steps.

205 production of light by living organisms via chemical reaction, is widespread across Metazoa.

206 ions utilizing a library of well-established chemical reactions and reagents.

207 The recent trend to control many chemical reactions by cooperative multiple weak interact

208 We demonstrate that heterogeneous/biphasic chemical reactions can be monitored with high spectrosco

209 as benefited from the development of several chemical reactions to modulate their membrane permeabili

210 bility of DNA-DNA interactions to accelerate chemical reactions under diluted conditions upon sequenc

211 unds, usually acids or bases, can accelerate chemical reactions when used in substoichiometric quanti

212 of biological processes, and elucidating how chemical reactivity is efficiently controlled within wel

213 respiratory activity comparable to that upon chemical reduction by ascorbate.

214 cal-anion salt K[7(*)] was generated through chemical reduction with K metal and characterized by EPR

215 kelihood of detecting plausible novel enzyme-chemical relationships.

216 Moreover, chemical releasing methods, such as beta-elimination/Mic

217 h compounds have an important biological and chemical relevance, the lack of methods for their produc

218 ven by the demands in production of valuable chemicals, remediation of hydrocarbon pollutants and ene

219 potential endocrine disruption via exogenous chemicals requires that aromatase inhibition be consider

220 An ongoing challenge in chemical research is to design catalysts that select the

221 This review is the counterpart of a 2018 Chemical Reviews article (Adero, P.

222 ted to different aspects of discovery in the chemical sciences.

223 Chemical screening revealed that inhibition of MEK/ERK s

224 ew current phenotypic models, as well as the chemical screening strategies most often employed.

225 frameworks (MOFs) has led to applications in chemical sensing and electrical energy storage, among ot

226 agents, their toxicity and their utility in chemical sensing.

227 Chemical sensitivity analysis (CSA) is a new probing too

228 pH sensors as transducers in biosensors and chemical sensors, and their integration into flow-inject

229 ed in industry for applications that include chemical separations and gas scrubbing.

230 Here, we report the discovery of a novel chemical series of non-bile acid FXR agonists based on a

231 In this sense, nucleus-independent chemical shift (NICS) and anisotropy of the induced curr

232 In this work, we developed NMR chemical shift calculation protocols using a machine lea

233 such models rely on determining the signs of chemical shift changes between the conformational states

234 find that CS-Rosetta sampling with unsigned chemical shift changes generates a diversity of structur

235 The preassigned NMR chemical shift data is shown to be vital for NMR structu

236 Only the (15)N chemical shift of A280 (the first residue of SP1) change

237 additional (133)Cs NMR signal with a unique chemical shift that is attributed to Cs atoms terminatin

238 ltiple regions with overlapping and changing chemical shifts are accurately tracked.

239 ly (1) H-(15) N dipolar couplings and (15) N chemical shifts have been routinely assessed in oriented

240 This protocol can calculate the NMR chemical shifts of a set of molecules using any availabl

241 (15)N-(29)Si coupling constants and (29)Si chemical shifts show a high and dependable correlation w

242 erimentally determined data (e.g., (13)C NMR chemical shifts) with those predicted for all possible t

243 thermal input and integrates temperature and chemical signals to produce a given behavioral output is

244 Due to the chemical similarity between trivalent inorganic arsenic

245 , drug-like molecules within the appropriate chemical space.

246 s (RAs) was shown to be dependent upon their chemical speciation in solution, their interactions with

247 mics and kinetics of divalent mercury Hg(II) chemical speciation need to be understood.

248 ad to a false negative rate of up to 80% for chemicals spiked at low levels in blood.

249 e periodically analysed for microbial count, chemical stability (pH, lipid oxidation, lipolysis), and

250 construction, Fe-HAF-1 displays exceptional chemical stability in organic and aqueous solvents over

251 However, the chemical stability of DNA challenges the complete erasur

252 Our chemical stability studies of ETPs along with cytotoxic

253 An unusual chemical stability was observed for sterically unprotect

254 impact of structural features on potency and chemical stability, informing future utility of ETPs in

255 ms, is of fundamental scientific interest in chemical structure and bonding, as nitrogen is uniquely

256 ncy of HF formation by DBD regardless of the chemical structure of the compounds.

257 The accuracy of chemical structure prediction enables the development of

258 While novel chemical structures can thus be found, selectivity is a

259 e quantified and, considering subclasses and chemical structures of individual species, 6 sphingolipi

260 l for energy conversion and storage, but the chemical structures present in this heterogeneous pigmen

261 In this work, we aim to link ligand chemical structures to MIEs for androgen receptor (AR) a

262 covalent frameworks composed of hierachical chemical structures.

263 NCI drug libraries representing a variety of chemical structures.

264 esis, and crystallographic and computational chemical studies to show that (i) the Out and In states

265 We describe our design, synthesis, and chemical study of a set of functional epidithiodiketopip

266 ing the binding orientation of the different chemical substituents proposed.

267 thereby rivaling the synaptic specificity of chemical synapses.

268 unctionalized silica resin to facilitate the chemical synthesis of peptides in organic solvent as wel

269 lies on bioinformatic algorithms followed by chemical synthesis to predict and then produce small mol

270 ing potentially valuable building blocks for chemical synthesis, have each been prepared from cyclope

271 lkylamines provides a continual challenge to chemical synthesis.

272 The physico-chemical, textural and color parameters and fluorescence

273 ollution represents a complex mixture of air chemicals that continually interact and transform, makin

274 nsus predictions were discussed with example chemicals; then, the models were implemented into the fr

275 that do not reflect the complete exposure of chemicals to biota and do not provide the complete halog

276 ilds on methods established for conventional chemicals to ensure alignment and avoid duplication.

277 ation ecotoxicity of one method proposed for chemicals to extrapolate chronic information from acute

278 ts, and highlight clobetasol as an important chemical tool for target validation.

279 presents an innovative way to explore purely chemical tools that can direct and control cellular beha

280 Chemical tools that detect active MALT1 have been report

281 Using genetic and chemical tools, we demonstrated that FACT is needed to o

282 To support rapid chemical toxicity assessment and mechanistic hypothesis

283 ologies have enabled previously inaccessible chemical transformations and have been widely used in bo

284 P2-Na(x)TmO(2)) often suffer from structural/chemical transformations when contacted with moist air.

285 catalysis is a hallmark of energy-efficient chemical transformations, but can only be achieved if th

286 s to identify natural biocatalysts for novel chemical transformations.

287 e Goddard Earth Observing System (GEOS)-Chem chemical transport model, we find that global surface ac

288 rtainty of particle dry deposition in global chemical transport models.

289 ltic pumps equipped with perfusion lines for chemical transport, and mirrors for laser beam guidance.

290 able starches, however, necessitates further chemical treatment to increase their hydrophobicity and

291 Facile chemical treatments provide a significant degree of flex

292 mercial processes for the production of bulk chemicals via a metabolic engineering approach it is nec

293 Microbiological measurements, chemical water quality data, and dye tracer tests provid

294 er information on the reported quantities of chemicals, we find that the scientific literature carrie

295 /[Formula: see text] Pyrite oxidation during chemical weathering on land consumes [Formula: see text]

296 tides, two plant immune regulators and eight chemicals which inhibit Candidatus Liberibacter spp. in

297 For chemicals which were relatively stable in the rivers, DG

298 OPERA application to enable screening of new chemicals with a defined applicability domain and accura

299 Arsenic is one of these environmental chemicals, with multiple epidemiology studies supporting

300 erivatives were prepared in moderate to good chemical yields varying from 32 to 64% according to two