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1 lex biomolecules has become a cornerstone of chemical biology.
2 binatorial chemistry, organic synthesis, and chemical biology.
3 cks for medicinal chemistry and as tools for chemical biology.
4 ellular functions is commonly referred to as chemical biology.
5 creasingly important topic in structural and chemical biology.
6 ufficiently validated, compounds employed in chemical biology.
7 on should find applications in many areas of chemical biology.
8 those of the azido group for applications in chemical biology.
9 rged as important bioorthogonal reactions in chemical biology.
10 pects on the possible further development of chemical biology.
11 nt roles as drug candidates and as tools for chemical biology.
12 drug discovery, proteomics, metabolomics and chemical biology.
13 s a classical model system for environmental chemical biology.
14 s powerfully enabling for drug discovery and chemical biology.
15 on in organic synthesis, drug discovery, and chemical biology.
16 e a stabilized diazo group as a reporter for chemical biology.
17 computational drug discovery and systems and chemical biology.
18 ing workflows relevant to drug discovery and chemical biology.
19 l for developing therapeutics and probes for chemical biology.
20 ndly affect the future of drug discovery and chemical biology.
21 synthetic chemistry, materials science, and chemical biology.
22 a significant challenge at the forefront of chemical biology.
23 s to address a wide range of applications in chemical biology.
24 biotechnology, transplantation medicine and chemical biology.
25 tant role of protein-protein interactions in chemical biology.
26 macological agents is a longstanding goal in chemical biology.
27 nic chemistry but have untapped potential in chemical biology.
28 reactivity could have substantial utility in chemical biology.
29 nt and improvement of intein-based tools for chemical biology.
30 many outstanding questions in biophysics and chemical biology.
31 ic cellular proteins are essential tools for chemical biology.
32 enetic alphabet has been a long-time goal of chemical biology.
33 ew lead identification in drug discovery and chemical biology.
34 the future use of carrier protein fusions in chemical biology.
35 ule interfaces represents a powerful tool of chemical biology.
36 catalysts remains a formidable challenge for chemical biology.
37 common to model self-replication systems in chemical biology.
38 for further advances in total synthesis and chemical biology.
39 lular organic synthesis with applications in chemical biology.
40 tructural biology, cloning, glycobiology and chemical biology.
41 to the key area of clinical diagnostics and chemical biology.
42 FRB, a system relevant in both medicine and chemical biology.
43 uncaging reactions offer versatile tools in chemical biology.
44 l issue in the fields of pharmaceuticals and chemical biology.
45 bitors are widely used in drug discovery and chemical biology.
46 well as their applications as probes and in chemical biology.
47 subcellular compartments is an unmet need in chemical biology.
48 ting applications in medicinal chemistry and chemical biology.
49 here has important implications for cell and chemical biology.
50 t this method could find new applications in chemical biology.
51 ter of what, 30 years later, would be called chemical biology.
52 organic synthesis, medicinal chemistry, and chemical biology.
53 become one of the great frontiers of modern chemical biology.
54 emerging field of RNA splicing chemistry and chemical biology.
56 ression in living cells is a central goal of chemical biology and antisense therapeutic development.
58 menon has found a variety of applications in chemical biology and biotechnology, precious little is k
59 FRET can be generalized with applications in chemical biology and biotechnology, such as target engag
63 ill find significant utility in the areas of chemical biology and chemically enabled/enhanced biother
64 earned about targeted protein degradation in chemical biology and drug discovery and systematically r
67 oteases, the undisputed potential of GTs for chemical biology and drug discovery has remained largely
68 e importance of alpha-helix-mediated PPIs to chemical biology and drug discovery with a focus on desi
73 r quality and utility across a wide range of chemical biology and drug-discovery research problems.
75 netics and drug discovery, but the fields of chemical biology and genetics have evolved to a point wh
78 be used to identify innovative compounds in chemical biology and in the early stages of drug discove
86 e nanoscale scaffolds that have relevance in chemical biology and nanotechnology, with diverse areas
88 s for further investigation of this strain's chemical biology and potential for interaction with its
90 AURKA inhibitors, with implications for the chemical biology and selective therapeutic targeting of
98 We have used a combination of cell biology, chemical biology, and enzymology approaches to analyze t
102 ations driven by advances in bioinformatics, chemical biology, and synthetic biology in concert with
103 en inhibitor candidates for therapeutics and chemical biology, and to unravel the diverse signaling c
107 e as scaffolds for the display of ligands in chemical-biology applications and as spacers and constru
109 Here, utilizing both a gain-of-function chemical biology approach and loss-of-function genetic a
113 ese phenotypes were recapitulated by using a chemical biology approach in which pyrazolopyrimidine-de
116 sults demonstrate that CHAMP is a successful chemical biology approach that can provide specific tool
124 colleagues address this shortcoming using a chemical biology approach to monitor ubiquitination with
127 As such, we provide proof of concept of this chemical biology approach to screen for inhibitors of li
131 c investigation of the WaaL function using a chemical biology approach, providing a system that could
141 biosynthesis and function are emerging, and chemical biology approaches are accelerating the pace of
143 foundation for further exploration utilizing chemical biology approaches focusing on validating this
144 Herein, we review the key chemistry and chemical biology approaches that have furthered our stud
145 l properties, H2S is an appealing target for chemical biology approaches to elucidate its production,
146 ion of high quality chemical tools and other chemical biology approaches to target validation in canc
147 molecular chemistry and the state-of-the-art chemical biology approaches to unravel the formation and
148 hosphorylation have been obtained with these chemical biology approaches, but continuing opportunitie
155 ument its current status with an emphasis on chemical biology aspects of modulating its activity to g
156 sumption by combining laser microsurgery and chemical biology assays in cultured mammalian cells.
159 mulated interest for various applications in chemical biology, bioseparations, drug delivery, and sen
161 nes has found widespread use in the field of chemical biology, but the mechanism of the transformatio
163 s of research involving medicinal chemistry, chemical biology, cancer biology, and molecular imaging.
168 y split inteins have found widespread use in chemical biology due to their ability to drive the ligat
174 advances in terpenoid cyclase structural and chemical biology, focusing mainly on terpenoid cyclases
175 e past years, it has been used especially in chemical biology for peptide/protein synthesis, posttran
176 rterial-venous identity and the potential of chemical biology for providing new insights into this fi
177 induced dimerization is an important tool in chemical biology for the analysis of protein function in
179 inned by many disciplines, but chemistry and chemical biology have undoubtedly played a significant r
181 gulon in P. aeruginosa by using genetics and chemical biology in combination with transcriptomics and
182 lockworks and highlight the effectiveness of chemical biology in exploring unidentified mechanisms of
184 upramolecular chemistry, in nanosciences, in chemical-biology, in polymers and materials science.
185 l to other protein-tagging methods in modern chemical biology including activity-based protein profil
186 catalytic X-H insertion towards problems in chemical biology indicate that this field has ample room
188 fluorescent dyes, and highlight the relevant chemical biology innovations that can be instrumental fo
190 me one of the main driving forces in current chemical biology, inspiring the search for novel biocomp
191 ulators of 14-3-3 are much needed agents for chemical biology investigations and therapeutic developm
192 the complementary approaches of genetics and chemical biology, involving a variety of model organisms
197 One of the grand challenges in contemporary chemical biology is the generation of a probe for every
198 the complementary strengths of genetics and chemical biology, it is hoped that novel therapeutic app
199 pportunities between synthetic chemistry and chemical biology labs interested in creating first-in-cl
203 ility, and is moving towards applications in chemical biology, nanotechnology and material science.
204 a foundation for studying the structural and chemical biology of arginase I in the immune response, a
205 this work sets a foundation for studying the chemical biology of autophagy through the structure-base
206 e literature also implies that the mammalian chemical biology of CS2 has broader implications from in
207 disclose our complete studies regarding the chemical biology of diazonamide A and its structural con
209 been hampered by a poor understanding of the chemical biology of inflammation, the lack of sensitive
215 cial to a comprehensive understanding of the chemical biology of psymberin and related compounds that
218 vides an additional tool for deciphering the chemical biology of the gut microbiome and might advance
219 as playing important roles in the mammalian chemical biology of the ubiquitous bioregulator nitric o
220 Aspects of the pharmacokinetic behavior and chemical biology of these drug candidates are also descr
221 his Review highlights both the chemistry and chemical biology of this fascinating natural product, an
223 y plays a fundamental and underlying role in chemical biology, pharmacology, and medicine to discover
225 It seeks to critically re-evaluate recent chemical biology practice, such as the presence of PAINs
226 ne functionality is frequently introduced in chemical biology probes as a click handle to identify mo
228 eveloped through a collaboration between the Chemical Biology Program and Platform at the Broad Insti
229 The results provide a novel integrative chemical biology proof in support of the neuroinflammati
230 splicing has found extensive applications in chemical biology, protein chemistry, and biotechnology.
231 is a host of methodological approaches from chemical biology, proteomics, genomics, cell biology, an
232 erdisciplinary and promises to revolutionize chemical biology, radiochemistry and materials science.
234 ng experiments, medicinal chemistry studies, chemical biology research and drug discovery programs.
241 In this work, we used a high-throughput chemical biology screen to identify a small-molecule pro
242 A recent elegant study published in Nature Chemical Biology sheds light on a new resistance mechani
244 lucidated through a combination of genetics, chemical biology, solution biochemistry, and crystallogr
246 We argue that complementary biological and chemical biology strategies are essential for robust tar
248 nding and, provides a suitable complement to chemical biology strategies for the discovery of novel S
250 synthetic antagonists, thus demonstrating a chemical biology strategy of using chemically engineered
252 engineered KAT enzymes, provide a versatile chemical biology strategy to label and profile cellular
256 , and this capability is being leveraged for chemical biology studies and clinical pathology, enabled
260 tational analysis, cell-free, cell-based and chemical biology studies that have sought to elucidate t
264 Our findings demonstrate the utility of chemical biology techniques in analysis of infection pro
266 e findings thus define a G-CSF effect on MPO chemical biology that endows unsuspected functional vers
267 combinant fragments-is a burgeoning field of chemical biology that has impacted many areas in the lif
268 al review focuses on an important example of chemical biology-the melding of old and new chemical kno
269 for use in fundamental biophysical studies, chemical biology, therapeutic protein development, and b
271 research areas ranging from bioanalysis and chemical biology to drug discovery and probing of cell-m
272 rged as a major opportunity in synthetic and chemical biology to generate novel biological insights a
274 Here, we combine molecular, structural and chemical biology to identify a determinant for PLK1 subs
275 stry, synthetic chemistry, biochemistry, and chemical biology to identify the substrates of peptidase
279 FabI inhibitor, AFN-1252, was deployed as a chemical biology tool to determine whether Neisseria can
280 zyl-2-pyridyl)quinazoline (BPQ), providing a chemical-biology tool which has been exploited in two li
281 These selective compounds are useful as chemical biology tools and for future drug discovery eff
282 rescent inhibitors that we show to be useful chemical biology tools especially in determination of di
283 it SPase, suggesting that they may be useful chemical biology tools for characterizing the secretome.
284 it SPase, suggesting that they may be useful chemical biology tools for characterizing the secretome.
285 s are amenable for bioconjugation, providing chemical biology tools for thaumatin:taste receptor inte
286 gest that the arylomycins should be valuable chemical biology tools for the study of protein secretio
287 5'-diphosphate ribose (cADPR) analogues are chemical biology tools that can probe the Ca(2+) release
295 ceptualizing the powerful proximity-enhanced chemical biology toolsets into two paradigms: "multifunc
297 lded in the areas of systems, synthetic, and chemical biology, where the need for comprehensive, hypo
299 provide researchers new to the field of H2S chemical biology with practical considerations, pitfalls