ライフサイエンスコーパス: chemically

1 acy of a new accelerated evolution platform, chemically accelerated viral evolution (CAVE), which pro

2 roviding an intriguing perspective of how to chemically access the underlying free energy landscape i

3 ngineering approach that harnesses the large chemically accessible surface areas of nanomaterials to

4 ghlight a computational framework from which chemically accurate results are obtained and address the

5 Microalgae enriched breads made with chemically acidified doughs or sourdoughs had higher Tot

6 e in the presence of either 10% sourdough or chemically acidified doughs.

7 Compared to Raw-, Unstarted- and Chemically Acidified-AP, Fermented-AP promoted the highe

8 that a cysteine in a recombinant protein was chemically activated by a small molecule cyanylating rea

9 HLB extracts were further studied with HepG2 chemically activated luciferase expression (CALUX) in vi

10 activation offers advantages over biological chemically activated molecular motors because one can di

11 ying can be initiated in the laboratory with chemically activated nucleotides, but continued copying

12 eactions that operate above 700 degrees C in chemically aggressive environments, where low heat and m

13 Cellular DNA is constantly chemically altered by exogenous and endogenous agents.

14 The gloves were chemically analyzed and several detected substances were

15 We have quantum chemically analyzed the competition between the bimolecu

16 of organic self-assembled monolayers (SAMs) chemically anchored to metal surfaces is a challenge.

17 oupled to proton transfer in a wide range of chemically and biologically important processes.

18 This new pathway is both chemically and electrochemically reversible in subsequen

19 The multi-redox active MPT undergoes four chemically and electrochemically reversible one electron

20 This ensemble of chemically and functionally diverse biomolecules is term

21 ies for structural characterization of these chemically and industrially important materials using NM

22 metal into semiconductors, and be thermally, chemically and mechanically stable.

23 up (PcG) proteins silence gene expression by chemically and physically modifying chromatin.

24 that domains are consistently resolved, both chemically and spatially, in a completely label-free man

25 s directed by electronic interaction between chemically and structurally dissimilar solids toward ato

26 Deep eutectic solvents are non-flammable, chemically and thermally stable solvents with low vapour

27 We chemically attached about 20 SOSIP trimers to NPs made o

28 ment of PPGs activatable by biologically and chemically benign visible and near-infrared (NIR) light.

29 protein surfaces are by no means passive but chemically biased to varying degree of net-negative repu

30 substrate-electrode, to which the protein is chemically bound, while for the WT Az that coordination

31 Engineering the band gap chemically by organic molecules is a powerful tool with

32 electrophiles as quantified through quantum chemically calculated affinity data.

33 tial route, albeit difficult, to address the chemically challenging nature of the Hop TPR2A target, w

34 cient energy for a modest lifestyle involves chemically challenging reactions catalyzed by complex en

35 anoscopic laboratory to directly observe and chemically characterize molecular and cell biological sy

36 pure product with high emulsifying action to chemically characterize the mucilage.

37 We show that it is feasible to use AFM-IR to chemically characterize this type of substrate buried un

38 elf-assembly of block copolymer films can be chemically characterized by IR-PiFM with relative ease.

39 haracteristic of individual tissue types and chemically characterized using tandem MS and high mass a

40 l, aldehyde, and catechol, were prepared and chemically characterized.

41 reductionist approaches oversimplify useful, chemically complex mixtures in an attempt to rationalize

42 apted to deployment in harsh environments or chemically complex systems.

43 o the challenge of selectively modifying the chemically complex, 23-membered macrocyclic scaffold of

44 y free from protein contamination, and it is chemically complex-reflecting a wide range of physiologi

45 e first to compare the methods for preparing chemically conjugated and recombinant A99 to elastin-lik

46 Both chemically conjugated and recombinant fusion between A99

47 d the extent to which trimers of laminin-111 chemically conjugated to FH (L(1p)T-FH) can increase the

48 Herein, DDS was chemically conjugated with five phytochemicals independe

49 We chemically construct multimeric standards to estimate th

50 The OP of two chemically contrasted PM(2.5) samples was compared throu

51 To overcome these limitations, we report chemically controllable triggering of single-virus fusio

52 In this work, we apply the chemically-controlled antigen-dissociation detection app

53 This work is the first demonstration on the chemically-controlled dissociation kinetics of antibody-

54 Although 3'-amino nucleotides can be chemically coupled to yield stable oligonucleotides cont

55 Pa levels are comparable or even higher than chemically cross-linked hydrogels and LC elastomers.

56 proteomics, the local interactomes of these chemically customized chromatin landscapes are determine

57 Chemically damaged DNA has been linked to cancer and agi

58 r the self-assembled monolayer (SAM) without chemically damaging the molecules and preventing an inte

59 ivorous lycaenids are warningly coloured and chemically defended.

60 ains three breakthrough articles: AntiBodies Chemically Defined (ABCD) curates antibody sequences and

61 potent stem cells (GM23338) with a series of chemically defined and serum-free media to induce format

62 the development of a long-term feeder-free, chemically defined culture system for distal lung progen

63 ically resected patient tumor tissue using a chemically defined medium without cell dissociation.

64 Here, we report a feeder-free, scalable, chemically defined, and modular alveolosphere culture sy

65 oduction of organoids and the development of chemically defined, animal origin-free (CD-AOF) media an

66 Consequently, we generate a minimal chemically-defined culture medium in which IGF1 together

67 ntative processing to fuels and chemicals or chemically deoxygenated to hydrocarbons.

68 n-metal-organic frameworks (protein-MOFs) as chemically designed protein crystals, composed of ferrit

69 ging this understanding, a class of SNAs was chemically designed which increases the siRNA content by

70 s based on COFs is the fact that they can be chemically designed, thus allowing the formation of a la

71 Here, we present chemically-detailed conformational movies of biological

72 at contains equal dosages of genetically and chemically detoxified toxins A and B.

73 deeper structural interrelationship in these chemically different classes of materials.

74 ent yields very good results for a number of chemically different nanoparticles, an exemplary protein

75 Adipose-derived stem cells (ASCs) can be chemically differentiated towards a SC-like phenotype (d

76 rane transporter that mediates the efflux of chemically dissimilar amphipathic drugs and confers resi

77 estrict the available materials, and joining chemically dissimilar components remains a challenge.

78 ransporter MdfA from Escherichia coli efflux chemically- dissimilar substrates in exchange for proton

79 KSs must recognize multiple chemically distinct ACPs and choreograph a ping-pong mec

80 allostery, and it is increasingly clear that chemically distinct agonists can produce different recep

81 Cannabis THS is a chemically distinct and prevalent form of THS, which has

82 tional use of rivers increasingly introduces chemically distinct anthropogenic DOM.

83 how odour relationships are encoded to place chemically distinct but similar odours, such as lemon an

84 ch to manipulate contactlessly and merge two chemically distinct droplets suspended in an acoustic le

85 d as scaffold for translating the binding of chemically distinct ligands to the control of diverse se

86 rum of TOC is represented by wide variety of chemically distinct methods, each having certain advanta

87 es between biosensor recruitment produced by chemically distinct opioid ligands in living cells.

88 We find that the two lineages acquire chemically distinct perfumes and are reproductively isol

89 d to co-deliver a model combination of three chemically distinct vaccine components, a dengue virus E

90 We further propose that chemically distinct, manmade DOM extends the natural ran

91 ernative because its intrinsic metabolome is chemically diverse and reflective for various biological

92 Beyond simple alkali metals and ammonium, chemically diverse cations including dendrimers, polyval

93 Inhaled anesthetics are a chemically diverse collection of hydrophobic molecules t

94 l energy of ATP facilitates translocation of chemically diverse compounds across membranes is poorly

95 A large number of chemically diverse compounds that are able to modulate G

96 Because siderophores are a chemically diverse group of molecules, with each siderop

97 Sphingolipids (SLs) are chemically diverse lipids that have important structural

98 d, being generalized sliced Wasserstein, for chemically diverse molecules with distributions similar

99 or opioid function and the discovery of many chemically diverse molecules with unique opioid-like eff

100 re identified by functional screening of 480 chemically diverse natural compounds in primary human ca

101 gen, indicating the coupling of oxidation of chemically diverse organic substrates to ubiquitous CO(2

102 y drugs, which are among the oldest and most chemically diverse set of drugs known.

103 es are often cheap, naturally occurring, and chemically diverse starting materials.

104 of a polymer, hypromellose (HPMC), and three chemically diverse surfactants, sodium dodecyl sulfate (

105 The application of chemically driven constraints is vital to achieving an a

106 anoscale is a central attribute of life, and chemically driven motor proteins are nature's choice to

107 ngerprinting method is presented and the new chemically-driven persistence image representation is us

108 nd reversible isomerization corresponding to chemically-driven symmetry breaking, is observed.

109 oniae serotype K2 is difficult to synthesize chemically due to the three 1,2-cis linkages in its stru

110 f interconnected BZ reactions we demonstrate chemically encoded and addressable memory, and we create

111 tidyl-oligonucleotide ribonucleases are here chemically engineered to create and attack bulge-loop re

112 nvironmental trade-offs and hotspots for the chemically enhanced primary treatment (CEPT) and low C/N

113 Stable electrospray was achieved through a chemically etched tip from a long (e.g., 50 cm) capillar

114 en from 1 to 15 sccm in a NiO(x) membrane on chemically etched vertical Si nanowires (SiNWs) in an el

115 terneurons that are specifically involved in chemically evoked persistent pain and pruritogen-induced

116 We compared structures of chemically extracted silica bodies (phytoliths) to silic

117 Comparison between recordings of chemically fixed and untreated, living cells indicate th

118 o amiodarone (10 muM) or medium for 24 h and chemically fixed.

119 pontaneously move on homogeneous surfaces by chemically forming and maintaining a local gradient of s

120 Sarecycline is distinguished chemically from other tetracyclines because it has a 7-[

121 Recently, synthetic analogs of chemically fueled assemblies have emerged, but examples

122 plexity on a multicomponent systems level in chemically fueled transient DNA polymerization systems,

123 We report chemically fuelled out-of-equilibrium self-replicating v

124 Unlike related reports of chemically fuelled self-replicating micelles, our vesicu

125 Herein, we report a chemically functionalized conical shaped poly-(ethylene

126 Here, we address this challenge by chemically functionalizing non-toxic silicon nanocrystal

127 Next, we chemically fuse two clusters to realize a larger cluster

128 arotenoids, natural pigments, are a group of chemically heterogeneous molecules, present in numerous

129 Furthermore, the chemically homologous nuclide (188)Re is available from

130 and a pneumococcal strain, D39, both produce chemically identical capsular PS.

131 we demonstrate that polycrystalline films of chemically identical molecules offer a promising alterna

132 agnitude improvement in affinity compared to chemically identical particles patterned incorrectly.

133 This study chemically identified their presence in insect tissues:

134 tically significant features, that are often chemically identified-where each feature corresponds to

135 mitations in applying different AFM modes to chemically image, sense, and manipulate biosystems at (s

136 Itch is induced chemically in the peripheral nervous system via a wide a

137 ise be recognised or preserved physically or chemically in the sediment record.

138 ticles morphologically, compositionally, and chemically in three-dimensions.

139 bstrates and transferred to structurally and chemically incompatible substrates, but epitaxial films

140 tration of a set of five small molecules can chemically induce the transformation of fibroblasts into

141 ression, micronuclei formation, and death of chemically induced cell fusions.

142 (-/-)) animals show increased sensitivity to chemically induced colitis and impaired proliferation in

143 iotics significantly reduces the severity of chemically induced colitis and wild type (WT) mice co-ho

144 tide production and increased sensitivity to chemically induced colitis associated with high incidenc

145 ing, detection antibodies are released using chemically induced complex rearrangement.

146 postnatal ages and were hypersusceptible to chemically induced convulsive seizures.

147 argets for the protection of hair cells from chemically induced death or from other insults, such as

148 se model and ~1 month diabetes correction in chemically induced diabetic mice.

149 iochemistry and cell-based assays, including chemically induced dimerization and single-molecule pull

150 To test these models, we developed a chemically induced dimerization approach to induce de no

151 Chemically induced GSK3beta inhibition bypassed the calr

152 t a complex plant cell shape can derive from chemically induced local and polarized expansion of the

153 876 on GluA2 (GluA2-Y876) is elevated during chemically induced LTP.

154 Using a chemically induced model of Parkinson's disease in mouse

155 ges are accepted as a sensitive indicator of chemically induced organ damage, but can be difficult to

156 The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into

157 though their thresholds for electrically and chemically induced seizures were similar to those of wil

158 hat TC-PTP contributes to the attenuation of chemically induced skin carcinogenesis through the syner

159 demonstrate that TWJ ligands are amenable to chemically induced synthetic lethality strategies upon a

160 ecause changes in organ weight might reflect chemically-induced changes in overall body weight.

161 deficient mice in a two-stage mouse model of chemically-induced cSCC, where a subclinical dose of 7,1

162 o models of H. pylori infection as well as a chemically-induced model of colitis, confirmed its predi

163 uced sweating was significantly different to chemically-induced sweating where the sweat chloride con

164 ion over three orders of magnitude, provides chemically inducible control of TF activity, and enables

165 tabolic processes, overcoming limitations of chemically inducible systems.

166 While various CID tools are available, chemically inducible trimerization (CIT) does not exist,

167 We show that chemically inert AFM tips terminated by an oxygen adatom

168 id EFC was developed for the conversion from chemically inert nitrogen gas to chiral amino acids, pow

169 106)RuCl(3), while 20% is both insoluble and chemically inert, consistent with the occurrence of RuO(

170 de made of UV-absorbing visibly fluorescent, chemically inert, machinable plastic.

171 When PLK4 is chemically inhibited, cell division proceeds without cen

172 By chemically inhibiting actin polymerization and by knocki

173 rams and chromatin architecture reveals that chemically inhibiting proteasome activity creates a dist

174 Herein, this problem is resolved by chemically installing extended pai-rich alternating carb

175 ce to nonequilibrium assembly in mixtures of chemically interacting colloids that are known to exhibi

176 xidation of the phenol results in an overall chemically irreversible two-proton-coupled electron-tran

177 cell RNA sequencing in which fixed cells are chemically labeled by attaching identifying DNA oligonuc

178 Previous studies used chemically labeled ligands or antibodies with a FRET (fl

179 Subsequently, azide groups on the CTLs were chemically labeled with near infrared fluorescence (NIRF

180 orine substitution has proven its merits for chemically mapping the importance of hydroxyl groups in

181 rize recent progress in the understanding of chemically mediated bacterial-fungal interrelations.

182 ous opportunities for comparative studies of chemically mediated eco-evolutionary dynamics.

183 Neutrophils play a vital role in both chemically mediating inflammatory response through myelo

184 ly emerge during experimental evolution in a chemically minimal environment containing glucose as the

185 Our findings demonstrate how chemically minimal systems can be designed with controll

186 nuclear metal-oxo clusters with discrete and chemically modifiable structures.

187 starches, starch-phenolic complexes were not chemically modified and had modestly lower estimated gly

188 ASO therapeutics are chemically modified and include phosphorothioate (PS) ba

189 n ferroelectricity and antiferromagnetism in chemically modified BiFeO(3), a concrete understanding o

190 Finally, recent advances in the use of chemically modified biopolymer hydrogels for the biofabr

191 ent that relies on homology-directed repair, chemically modified donor DNA and the presence of tandem

192 ing roles of a metal-free nanozyme hybrid of chemically modified graphitic carbon nitride (MGCN), chi

193 We examined the efficiency of synthetic, chemically modified gRNAs and demonstrate induction of i

194 A unique feature of this study is the use of chemically modified micromodels such that the pore surfa

195 Here we engineer a chemically modified mRNA-encoded adenine base editor tha

196 Identification of post-translationally or chemically modified peptides in mass spectrometry-based

197 Support for chemically modified residues and nucleotides has been si

198 issue, we tested peptide nucleic acid (PNA), chemically modified RNA and their hybrids with DNA as al

199 ia lipid-nanoparticle-mediated delivery of a chemically modified sgRNA and an mRNA of a codon-optimiz

200 the biostability of these aptamers, we also chemically modified these aptamers by substituting their

201 A glassy carbon electrode (GCE) is chemically modified using CD-CuMOF and carbon nanofibers

202 GMT was chemically modified with a hydrolysable linker, and subs

203 on toward tolerance, food compounds could be chemically modified, for example, by posttranslational p

204 ose TA systems in which the enzyme antitoxin chemically modifies the toxin post-translationally to ne

205 vent sides of the LSU, where they refold and chemically modify the rRNA and prevent early translation

206 new opportunities to design superlattices by chemically modifying simple perovskite oxides with tunab

207 gies for crosslinking are poorly reversible, chemically modifying the RNA and hindering molecular ana

208 ntal data in which the speed of onset can be chemically modulated.

209 man disorders, making attractive the idea of chemically modulating it with therapeutic purposes.

210 ography revealed that Aequorea CPs contain a chemically novel chromophore with an unexpected crosslin

211 s in mice in which liver fibrosis is induced chemically or by diet.

212 By chemically or genetically inducing centrosome loss in no

213 reasingly difficult management challenge and chemically or photochemically cross-linking the cornea f

214 ribed to the presence of reduced metal ions, chemically or photochemically generated during the first

215 This motivates to develop a chemically orthogonal HTL that consists of malonic-acid-

216 trix, which is enabled by the development of chemically-orthogonal and intrinsically stretchable diel

217 samples, that is, samples are matrix matched chemically, physically, and instrumentally.

218 screening in a medium throughput fashion to chemically probe the surfaces used by proteins to intera

219 a higher affinity for the DNA cargo enabled chemically programmed communication between both protoce

220 Iron is essential yet also highly chemically reactive and potentially toxic.

221 Here we apply chattering dust, or chemically reactive grains of sucrose containing pockets

222 i(2)IrO(3) which upon oxidation/delithiation chemically reacts with water to form a hydrated birnessi

223 By chemically reconfiguring them to recognize representativ

224 existing endogenous cellular machineries to chemically redirect biological targets and pathways.

225 ulfide-linked ADCs captured from plasma were chemically reduced at basic pH to release the linker-dru

226 Here, we show that chemically reduced metal-organic framework materials of

227 etrotransposable elements evolutionarily and chemically related to the eukaryotic spliceosome, with p

228 O-Glycans were chemically released from isolated cell membrane glycopro

229 e approach revealed that this hybrid is more chemically reminiscent to M. pyrifera.

230 dition, use of visible light-induced XPS for chemically resolved electrical measurements (CREM) confi

231 nucleophile, hydroxylamine hydrochloride, to chemically reverse inter- and intra-crosslinks from endo

232 l-defined hydrogen-bond network in achieving chemically reversible multiproton translocations trigger

233 somer, at high scan rates (~1000 mV s(-1)) a chemically reversible process is observed with an E(1/2)

234 eoretical evidence indicates that an overall chemically reversible two-proton-coupled electron-transf

235 The oxidation of 1 is also chemically reversible, where treatment of [1](*+) with f

236 c voltammetry, provided the PCET reaction is chemically reversible.

237 Even in chemically rich animals, such compounds have been found

238 carbon-fluorine (C-F) bond is among the most chemically robust bonds; consequently, the degradation o

239 method which photocages highly reactive but chemically selective moieties, enabling the use of prote

240 gle-chain variable fragment-based bispecific chemically self-assembled nanorings (CSANs) can successf

241 ce-mediated assembly (SMA) of the NCs/NPs as chemically sensitive interfaces, the resulting fibrous c

242 n their catalytic activity when subjected to chemically similar but non-native metal substitutions is

243 fferentiation among the ubiquitous and often chemically similar C-H bonds remains a significant chall

244 The difference in ZT between two chemically similar compounds underscores the importance

245 ynamics simulations of the interactions with chemically similar fluorescent probes.

246 ial polymerization to prepare physically and chemically similar selective layers of controlled thickn

247 noids at specific alkene bonds while leaving chemically similar sites within the polyene intact.

248 placement and network analysis revealed that chemically similar substituents preferentially occurred

249 d into one containing a lead phosphate solid chemically similar to phosphohedyphane (Ca(2)Pb(3)(PO(4)

250 ed as far as clinical trials, especially the chemically simple, linear examples.

251 cule junctions, using the organic termini to chemically "solder" a single cluster to two nanoelectrod

252 e-activated cell sorting by directly probing chemically specific intracellular molecular vibrations v

253 s a promising analytical tool for label-free chemically specific microscopy of lipid bilayers.

254 itters for solid-state quantum technologies, chemically specific sensing, and near-infrared bioimagin

255 pattern p-nitroaryl OCCs, which demonstrate chemically specific spectral signatures at programmed po

256 hem essentially non-equilibrium systems, the chemically-specific heterostructures predicted here are

257 The chemically stabilized C/S composite retains a high rever

258 Chemically stabilized peptides have attracted intense in

259 inity of the parental antibody, and utilizes chemically stabilized siRNA.

260 Graphene is a lightweight, chemically stable and conductive material that can be su

261 f cerebral lesions at MRI may benefit from a chemically stable and more sensitively detected gadolini

262 form kinetically stable compounds often with chemically stable N-N bonds but which are thermodynamica

263 drolysate (WPH) for producing physically and chemically stable omega-3 emulsions was compared to hydr

264 separated by a porous insulator, serve as a chemically stable substrate for the cells.

265 proach opens new ways for rapid discovery of chemically stable vdW materials that exhibit magnetic be

266 le pharmacophoric scaffold for the design of chemically stable, highly potent and selective Kv7 agoni

267 ncluding paraffin-embedded, fresh frozen and chemically stained human tissues.

268 demonstrated the use of cpRAPID to generate chemically switchable split nanobody (designated Chessbo

269 on of probes (Ag(2)S superdots) derived from chemically synthesized Ag(2)S dots, on which a protectiv

270 Addition of the chemically synthesized CIP peptide initiates cell-cycle

271 The chemically synthesized compounds had in vitro binding af

272 iently generate recombinant MVA vectors from chemically synthesized DNA.

273 To pair the speed and sensitivity of chemically synthesized fluorescent indicators with cell-

274 ng, a pertussis-LPS-like pentasaccharide was chemically synthesized for the first time.

275 ist of a small molecule or antibody fused to chemically synthesized glycopeptide ligands that are ago

276 rface plasmon resonance (LSPR) properties of chemically synthesized gold nanostructures, gold triangu

277 pecific properties in comparison to abiotic, chemically synthesized magnetite.

278 We implemented the method using either chemically synthesized oligonucleotides or amplicon-base

279 These results demonstrate the value of chemically synthesized probes for the elucidation of the

280 Acalpha2,3Galbeta1,4Glcbeta-ONH(2)) has been chemically synthesized using a linear glycosylation appr

281 eered protein-based adhesives and biomimetic chemically synthetized adhesives.

282 gineered glycosyltransferases to incorporate chemically tagged sugars into the cell surface glycome o

283 ications are then converted enzymatically or chemically to strand-breaks for both 3'-extension by nic

284 persed, they are usually cationic and bonded chemically to supports.

285 These reactions are chemically tolerant and incorporate a wide range of func

286 in as a model, its sequence was exploited to chemically transform a single cysteine, such that the ex

287 e converted to PLJ, and ingested PLJ was not chemically transformed during gastrointestinal tract tra

288 calable synthesis of wholly new materials by chemically transforming the polymers, especially product

289 the cryo-electron microscopy structure of a chemically trapped complex that represents the ubiquityl

290 hylene terephthalate/glass fiber, nontreated/chemically treated) as well as possible transport and st

291 ere, we develop a model system consisting of chemically tunable, highly luminescent halide perovskite

292 Herein, we describe chemically tuning the electrophilicity of the alpha-meth

293 magnetosomes are stable and structurally and chemically unaffected at temperatures up to 300 degrees

294 the top of the vegetation canopy and fresh, chemically unaltered bedrock and plays a pivotal role in

295 s based on structural similarity to identify chemically unique conformations, (4) DFT structural opti

296 d to water, creating a significant amount of chemically unique packing defects, and the acyl chains e

297 ersensitivity reaction (DHR) to at least two chemically unrelated drugs, confirmed by skin test or in

298 Yttrium is a chemically versatile rare earth element that finds use i

299 hput anti-RABV drug screens and identified a chemically well-behaved, first-in-class hit with nanomol

300 xtent to which site-specific attachment to a chemically well-defined macroscopic surface alters the a