ライフサイエンスコーパス: chemically-modified

1 , which are smaller in size and easier to be chemically modified.

2 structure-activity correlation, mahanine was chemically modified.

3 lated grafted sites when silica surfaces are chemically modified.

4 f RNA-based therapeutics, even when they are chemically modified.

5 internal space whilst outer surfaces can be chemically modified.

6 w selective regions of a nanostructure to be chemically modified.

7 Here we develop a chemically modified, 29-nucleotide synthetic CRISPR RNA

8 A series of chemically modified 7-phenylpyrrolo[3,2-f]quinolinones w

9 and in high purity, and a fixed Cas9-binding chemically-modified 79-mer, produced cost-effectively on

10 ncolytic peptides, we identified a series of chemically modified 9-mer cationic peptides that were hi

11 Most proteins in nature are chemically modified after they are made to control how,

12 e toward carbohydrates-on native agarose and chemically modified agarose in the gel phase for the fir

13 ble in Europe, including adsorbed allergens, chemically modified allergens, or both.

14 These chemically modified amino acids are used for the introdu

15 In previous work, our group chemically modified an antimicrobial peptidomimetic moti

16 In this study, we have synthetized chemically modified analogs of cloxyquin and tested thei

17 ablished as a platform for bio-conversion of chemically modified analogues of pleuromutilin intermedi

18 firefly emitter oxyluciferin and two of its chemically modified analogues revealed that in the excit

19 effects, hence the continuous development of chemically modified analogues with dissociated profiles.

20 rated silencing miRNA function in mice using chemically modified and cholesterol-conjugated RNAs term

21 lpha in multiple cell types and tissues, was chemically modified and conjugated to a thermally respon

22 starches, starch-phenolic complexes were not chemically modified and had modestly lower estimated gly

23 ASO therapeutics are chemically modified and include phosphorothioate (PS) ba

24 In brief, the NC surface was chemically modified and then was decorated with silver a

25 Intravenous administration of 2 mg kg(-1) chemically modified anti-miR-122 complexed with iNOP-7 r

26 ring mice with miR-10b antagomirs-a class of chemically modified anti-miRNA oligonucleotide-suppresse

27 The resulting chemically modified antibody fragment, RGD-Man(5)-IgG1 F

28 A chemically modified antisense oligonucleotide (ASO) that

29 Chemically modified antisense oligonucleotides (ASOs) ar

30 Chemically modified antisense oligonucleotides (ASOs) de

31 echanism of inhibition of gene expression by chemically modified antisense oligonucleotides (ASOs) ha

32 mouse cells by conventional transfection of chemically modified antisense oligonucleotides (ASOs) th

33 In this work, we utilized very short chemically modified antisense oligonucleotides composed

34 As an alternative to chemically modified antisense oligonucleotides, we devel

35 ess microRNA targets at least as strongly as chemically modified antisense oligonucleotides.

36 of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides.

37 ils the structure-activity relationships for chemically modified apelin peptides and recent disclosur

38 t cell types and species upon treatment with chemically modified ASOs targeting 5' UTR inhibitory reg

39 gRNAs of Cas9 and Cpf1, and donor DNA can be chemically modified at their terminal positions without

40 -protamine-RNA nanoparticles encapsulating a chemically modified ATF mRNA resulted in inhibition of o

41 -OP with the original K90C mutant, with K90C chemically modified back to a lysine analog (K90C-AE), a

42 hylcytosine (5mC) represents the most common chemically modified base in eukaryotic genomes.

43 The chemically modified base is an N(2)-alkyl-8-oxo-7,8-dihy

44 ent a novel strategy using oligos containing chemically modified bases (2'-Fluoro-Uridine, 5-Methyl-d

45 afeguard the genome by locating and excising chemically modified bases from DNA.

46 sylases help maintain the genome by excising chemically modified bases from DNA.

47 ch would enable the incorporation of various chemically modified bases throughout long stretches of D

48 By using chemically modified bases, we show electron trapping on

49 responsible for correcting a large number of chemically modified bases.

50 n ferroelectricity and antiferromagnetism in chemically modified BiFeO(3), a concrete understanding o

51 Finally, recent advances in the use of chemically modified biopolymer hydrogels for the biofabr

52 appealing substrates for the development of chemically modified biotherapeutics and protein-based ma

53 For chemically modified BNNTs with various amino functional

54 We have investigated properties of chemically modified boron nitride nanotubes (BNNTs) with

55 Carbon nanotubes can be chemically modified by attaching various functionalities

56 and aS fibrils, testing their ability to be chemically modified by DHA.

57 The CH3 NH3 PbI3 perovskite is chemically modified by introducing SrCl2 in the precurso

58 orted dibenzepinones and dibenzoxepines were chemically modified by introduction of functional groups

59 Cellular RNAs are chemically modified by many RNA modification enzymes; ho

60 ally administered drugs, that many drugs are chemically modified by microorganisms.

61 Proteins bearing this "aldehyde tag" were chemically modified by selective reaction with hydrazide

62 Membranes coated with SiNPs and chemically modified by the FAS with a longer fluoroalkyl

63 plausibility that the diamond surface can be chemically modified by the well-known carbene addition c

64 stal structure of DHQ1 from Salmonella typhi chemically modified by this ammonium derivative revealed

65 In this protocol, externalized APLs are chemically modified by using a cell-impermeable reagent

66 Their surface can be chemically modified, by either covalent or non-covalent

67 urther demonstrated by the construction of a chemically modified C2A domain of Synaptotagmin-I protei

68 ral requirements by assessing the ability of chemically modified C4S to inhibit IRBC binding to the p

69 Chemically modified carbon nanotube fibers enable unique

70 of epinephrine (EP) at a gold nanoparticles chemically modified carbon paste electrode (AuNPs/CPE).

71 The proposed chemically modified carbon paste electrode was used for

72 thesized and applied to the fabrication of a chemically modified carbon paste electrode.

73 ernative as compared to macro-electrodes and chemically modified carbon paste electrodes in stripping

74 The method used a chemically modified CE capillary to prevent protein adso

75 The study also presents chemically-modified cellulosic paper strips with the pyr

76 sense mediated reduction of Ago proteins and chemically modified cleavage- and binding-deficient siRN

77 CMC2.24, a novel tri-ketonic chemically modified compound based on natural di-ketonic

78 Chemically modified corn starch with sodium trimetaphosp

79 and to glucosaminoglycans, was adsorbed on a chemically modified CPLL solid phase, and the behavior o

80 pitope may be present in both the native and chemically modified CPS fragments.

81 ological activities are synthesized, using a chemically modified cyclic oligosaccharide.

82 Therefore, our major goal was to develop a chemically modified cyclodextrin which gives a more stab

83 le of these amino acids present in HcRed, we chemically modified Cys and His residues using iodoaceta

84 as developed based on one-shot adsorption of chemically-modified cytochrome c (cyt c) onto bare gold

85 In this study, we chemically modified DAFP-1 using the arginine-specific r

86 e binding of HCV envelope glycoproteins with chemically modified derivatives of heparin.

87 implications for understanding the states of chemically modified DNA bases in health and disease.

88 translesion synthesis across a wide range of chemically modified DNA templates.

89 ion: what is XNA and how does it differ from chemically modified DNA?

90 e for traceability of highly-degraded and/or chemically-modified DNA material.

91 ds developed in mammalian cells(12), we used chemically modified donor DNA and CRISPR-Cas9 to insert

92 ent that relies on homology-directed repair, chemically modified donor DNA and the presence of tandem

93 The proposed chemically modified electrode was used to the determinat

94 Both, the chemically modified enzyme (GOx-FS) and the UCLNPs are i

95 Chemically modified enzyme was also delivered more effec

96 In this respect, the chemically modified enzyme was superior to native beta-g

97 uraminic acid lyase (NAL), and the resulting chemically modified enzymes were screened for activity w

98 Similarly, chemically modified flavin analogs showed high affinity

99 lly occurring flavin derivatives and several chemically modified flavin analogs.

100 d abyssinone II and olympicin A, a series of chemically modified flavonoid phytochemicals were synthe

101 evaluation of ordered pillar arrays that are chemically modified for planar chromatography and inspec

102 on toward tolerance, food compounds could be chemically modified, for example, by posttranslational p

103 PI3K inhibitor was generated by coupling the chemically modified form of the quercetin analogue LY294

104 he stability of added cyanocobalamin (CNCbl, chemically modified form) and hydroxocobalamin (OHCbl, n

105 Sia come in chemically modified forms, but we lack a clear understan

106 An isonicotinic acid hydrazide (INAH) chemically modified fumed silica, as a novel adsorbent,

107 re much lower and much more uniform than for chemically modified fused silica.

108 The chemically modified gelatins exhibited better physical p

109 DNA ligation for the enzyme-free assembly of chemically modified genes and genomes.

110 Electrostatic-gated transport in chemically modified glass nanopore electrodes with orifi

111 , anti-EGFR RNA aptamers were immobilized on chemically modified glass surfaces.

112 RNA microarrays were created on chemically modified gold surfaces using a novel surface

113 of multiwalled carbon nanotubes (MWCNT) and chemically modified graphene (rGO)-composite spray coati

114 present a potentiometric aptasensor based on chemically modified graphene (transducer layer of the ap

115 The ease of its conversion to chemically modified graphene could enable new opportunit

116 ted network of close-packed laminates in the chemically modified graphene films also yields finely-tu

117 ural origins, pre-strech is applied to endow chemically modified graphene films with controlled negat

118 at the microstructural hierarchy of pristine chemically modified graphene films, featuring wrinkles,

119 umber of methods for generating graphene and chemically modified graphene from graphite and derivativ

120 Additional experiments on chemically modified graphene oxide membranes, with ring-

121 nd molecular-level dispersion of individual, chemically modified graphene sheets within polymer hosts

122 templates and the controlled segregation of chemically modified graphene to liquid interfaces.

123 port across the interfaces of physically and chemically modified graphene with two metals, Al and Cu,

124 oduce new materials composed of graphene and chemically modified graphene.

125 king a hydrogen bonding polymer network with chemically-modified graphene oxide.

126 ted here is likely to be applicable to other chemically modified graphenes and graphite-based systems

127 Chemically modified graphenes and other graphite-based m

128 n-13-labeled graphite can be used to prepare chemically modified graphenes for 13C SSNMR analysis wit

129 hite almost 150 years ago and a precursor to chemically modified graphenes, has not been previously r

130 ments for a nanoscale probe tip sliding on a chemically modified graphite surface in an atomic force

131 ing roles of a metal-free nanozyme hybrid of chemically modified graphitic carbon nitride (MGCN), chi

132 We examined the efficiency of synthetic, chemically modified gRNAs and demonstrate induction of i

133 When chemically modified, HA can be transformed into many phy

134 ochemical data on the cleavage properties of chemically modified hammerheads.

135 f copper addition on the fluorescence of the chemically modified HcRed was investigated.

136 polymer-encapsulated and additional forms of chemically modified hemoglobins are being developed and

137 fate and heparin oligosaccharides as well as chemically modified heparin oligomers have been successf

138 ved oligosaccharides (4-22 saccharides), and chemically modified heparins (2-O-, 6-O-, O-, and N-desu

139 Chemically modified heparins lacking N-sulfate and 2-O-s

140 In this labeling method, peptides are chemically modified in solution and the modified peptide

141 end, lysine amino acid residues of VWF were chemically modified in the presence of FVIII or activate

142 Chemically modified indium tin oxide nanoparticle modifi

143 teinogenic amino acids and for the design of chemically modified inhibitors.

144 O and a hole-transport overlayer through the chemically-modified interface.

145 the synthesis of antibiotics via a series of chemically modified intermediates, with removal of the p

146 herapeutic benefit of cyclocreatine or other chemically modified lipophilic analogs of Cr.

147 Additional injury by chemically modified lipoproteins disrupts the continuous

148 or drug delivery system in tumor cells using chemically modified liposomes for loading with chemother

149 roitin sulfate (CS) glycosaminoglycans using chemically modified liposomes.

150 A unique feature of this study is the use of chemically modified micromodels such that the pore surfa

151 Treatment with a chemically modified miR-21 inhibitor led to significant

152 ivo blockade of both miRNAs via antagomiR (a chemically modified miRNA inhibitor) injection after sep

153 t these processes are important for clearing chemically modified mRNA and the resulting aberrant-prot

154 Chemically modified mRNA is an efficient, biocompatible

155 Chemically modified mRNA is capable of inducing therapeu

156 Here we engineer a chemically modified mRNA-encoded adenine base editor tha

157 Our chemically modified muCF electrodes allow straightforwar

158 electron microscopy, we have characterized a chemically modified mutant of GroEL (EL43Py) that is tra

159 Here we use a chemically modified mutant of GroEL (EL43Py) to uncouple

160 However, many chemically modified nanoclay materials are incompatible

161 e show that adsorption of the protein to the chemically modified nanopores slows down the translocati

162 hSOx was adsorbed onto this chemically modified nanostructured electrode with high s

163 Interactions of chemically modified nucleic acid therapeutics with plasm

164 ls that predict the properties of native and chemically modified nucleic acids and assist in their de

165 tides covalently linked to nucleic acids, or chemically modified nucleic acids, enable the insertion

166 s that protect genomic stability by excising chemically modified nucleobases that alter normal DNA me

167 n of the sugar conformational preferences of chemically modified nucleosides in solution.

168 Unnatural chemically modified nucleotide sugars UDP-4-N3-GlcNAc an

169 indings provide information on incorporating chemically modified nucleotides into siRNAs for potent,

170 The capability of DNA polymerases to accept chemically modified nucleotides is of paramount importan

171 ll interfering RNAs (siRNAs) are composed of chemically modified nucleotides, which enhance RNA stabi

172 reaction products by using radio-labeled or chemically modified nucleotides.

173 A chemically modified oligonucleotide targeting lnc-MGC in

174 nambiguous sequence assignment of an unknown chemically modified oligonucleotide.

175 inducible RNAi platform in which orthogonal chemically modified oligonucleotides are used to trigger

176 could potentially be avoided by introducing chemically modified oligonucleotides into the MB design.

177 Chemically modified oligonucleotides that disrupt the in

178 e tool to provide high sequence coverage for chemically modified oligonucleotides, and such detailed

179 assay suitable for the detection of heavily chemically modified oligonucleotides, which we termed Ch

180 limitations of IT-CID in sequencing such 2'-chemically modified oligonucleotides.

181 ysis program for confirmation of sequence of chemically modified oligonucleotides.

182 When delivered by nucleofection, chemically modified ON of both types effected a >90% kno

183 Glycans were enzymatically or chemically modified on solid phase before releasing from

184 The lanthanum oxide is chemically modified on the surface of silica and charact

185 PAHs, including the large variety of chemically modified or substituted PAHs, are naturally o

186 Cellular RNAs can be chemically modified over a hundred different ways.

187 therapeutic efficacy of a well-characterized chemically modified peanut extract (MPE) adsorbed to Al(

188 In vitro selection of chemically modified peptide libraries presented on phage

189 We report the development of chemically modified peptide nucleic acids (PNAs) as prob

190 st the DNA binding and sliding activities of chemically modified peptides and analogs, and show that

191 Identification of post-translationally or chemically modified peptides in mass spectrometry-based

192 Using truncated and chemically modified peptides, we show that abasic site c

193 s for efficient delivery of conventional and chemically-modified peptides nucleic acids.

194 r membrane localization of proteins by using chemically modified phospholipid anchors capable of cova

195 The molecular mechanisms of toxicity of chemically modified phosphorothioate antisense oligonucl

196 Di-siRNAs are composed of two fully chemically modified, phosphorothioate-containing siRNAs

197 Here, we report the effect of chemically modified phytoglycogen, a dendrimer-like alph

198 characterise a stable and uniformly reactive chemically modified platinum electrode for NADH electroc

199 e qualitative and quantitative properties of chemically modified PNA for nucleic acid detection and p

200 Chemically modified proteins are increasingly important

201 Chemically modified proteins are invaluable tools for st

202 enzymatic method that allows broad access to chemically modified proteins.

203 ailable, enabling absolute quantification of chemically modified proteoforms, and therefore systems-l

204 Chemically modified PS-ASOs can mediate efficient target

205 The chemically modified PSMA inhibitor PSMA-617 demonstrated

206 Different methods to design the chemically-modified QDs hybrid structures for sensing lo

207 The chemically modified reaction intermediate is consistent

208 Delivery of native or chemically modified recombinant proteins into mammalian

209 con oxycarbide glass particles embedded in a chemically-modified reduced graphene oxide matrix.

210 nscription proceeds until it is blocked by a chemically modified residue.

211 Support for chemically modified residues and nucleotides has been si

212 al and in vivo bone regenerative capacity of chemically modified ribonucleic acid (cmRNA) (encoding B

213 issue, we tested peptide nucleic acid (PNA), chemically modified RNA and their hybrids with DNA as al

214 ow that the same approach can be extended to chemically modified RNA, an important feature for applic

215 internal mismatch pairs involving native or chemically modified RNA.

216 terference has reinvigorated the interest in chemically modified RNA.

217 ) were used, for the first time, to assemble chemically modified Screen Printed Electrodes (SPEs) sel

218 Functional and structural studies based on chemically modified semisynthetic KcsA channels along th

219 ia lipid-nanoparticle-mediated delivery of a chemically modified sgRNA and an mRNA of a codon-optimiz

220 Co-delivering chemically modified sgRNAs with Cas9 mRNA or protein is

221 ations of the two 21-mer single strands of a chemically modified short interfering RNA containing 2'-

222 liver has been through the administration of chemically modified short interfering RNAs.

223 Measurement of the surface area of chemically modified silica-based adsorbents is discussed

224 structure-activity relationships correlating chemically modified single strands and Argonaute 2 (AGO2

225 Chemically modified single-walled carbon nanotubes (SWNT

226 ased and in vivo assays to rationally design chemically modified siRNA destined for therapeutic use.

227 ry N-acetylagalactosamine (GalNAc) ligand to chemically modified siRNA has enabled asialoglycoprotein

228 g 2'-O-methyl and 2'-deoxy-2'-fluoro (OMe/F) chemically modified siRNA targeting PTEN and Eg5.

229 The optimally chemically modified siRNA-GalNAc conjugates are hepatotr

230 Chemically modified siRNAs are necessary that maintain m

231 Because chemically modified siRNAs are poor substrates for phosp

232 Chemically modified siRNAs exhibited binding affinities

233 ited success in enhancing siRNA potency with chemically modified siRNAs, our findings represent an im

234 These include chemically-modified siRNAs and analogues, aptamer-siRNA

235 tion events, while others represent putative chemically modified sites of unknown types.

236 s bearing positive and negative charges onto chemically modified SPR sensors in two separate SPR chan

237 Chemically modified ss-siRNA targeting human apoC III mR

238 These data demonstrate that chemically modified ss-siRNAs function through the RNAi

239 mization and alternative routes of delivery, chemically modified ssRNAs could represent a powerful RN

240 Inclusion complexes with chemically modified starch showed a lower range of therm

241 ng efficiency 3% and 10% higher than PVA and chemically modified starch sizes on polyester/cotton fab

242 /4 type resistant starch (retrograded starch/chemically-modified starch) with good texture-forming pr

243 satisfied hydrogen bonding groups by placing chemically modified substituents in select internal posi

244 A series of chemically modified substrate molecules with altered sub

245 on with a novel motility assay that employed chemically modified surfaces to probe the mechanochemist

246 echanism of protection for mice treated with chemically modified tetracycline 3, appeared to be relat

247 cal inhibitors of MMP (MMPi; captopril and a chemically modified tetracycline) and reserved infected

248 Accordingly, we utilized chemically modified tetracycline-3 (CMT-3)-a derivative

249 , and -9 inhibition, such as MMP inhibitors, chemically modified tetracyclines, and subantimicrobial

250 the biostability of these aptamers, we also chemically modified these aptamers by substituting their

251 dentified 3-cyano-4,6-diphenyl-pyridines, we chemically modified this scaffold and explored its struc

252 sevenfold symmetrical cyclodextrin molecule chemically modified to add seven positive charges, was g

253 adation rates from hours to years and can be chemically modified to alter surface properties or to im

254 Two different sequences of siRNA were chemically modified to be randomly copolymerized in a si

255 articles through physical interactions or be chemically modified to covalently accommodate cargos.

256 PerT-GUS, a form of beta-glucuronidase (GUS) chemically modified to eliminate its uptake and clearanc

257 veness of "self-delivery" siRNA (i.e., siRNA chemically modified to enhance cellular uptake).

258 endent antisense oligonucleotides (ASOs) are chemically modified to enhance pharmacological propertie

259 Most antisense drugs are chemically modified to enhance their pharmacological pro

260 ional evidence that long-circulating enzyme, chemically modified to escape carbohydrate-mediated clea

261 The tip end is chemically modified to hybridize only to the target mRNA

262 therefore designed a c-Fos peptide receptor chemically modified to incorporate a thiophenol (TP) gro

263 and Pinto bean starches were physically and chemically modified to investigate the effect of modific

264 nsport material into cells, the rotaxane was chemically modified to lock it in the closed conformatio

265 rporate a non-natural amino acid that can be chemically modified to modulate FcRn interaction in vitr

266 Transcription factors must often be chemically modified to perform their functions.

267 ls containing interconnected porosity can be chemically modified to promote stimulus-driven (light, m

268 etyl-Gly-Lys-O-methyl ester (dipeptide) were chemically modified to yield CEP-modified HSA (CEP-HSA)

269 rus particle underneath the MOF shell can be chemically modified using a standard bioconjugation reac

270 A glassy carbon electrode (GCE) is chemically modified using CD-CuMOF and carbon nanofibers

271 A chemically modified variant of CSN5 siRNA was then selec

272 Duplex dsP21-322 and its chemically modified variants are examples of RNAa-based

273 Analysis of chemically modified variants of the closing base pair sh

274 ct energetics of basic RNA motifs, including chemically modified variants, with consistently better t

275 ular proteomes, increasingly including their chemically modified variants.

276 on in which gene expression changes with the chemically modified VEGF PQS.

277 tion is well-suited to deliver synthetic and chemically modified versions of functional proteins, and

278 We established that the chemically modified VoltageFluor is a substrate for PLE

279 These chemically modified water soluble PHAs have significant

280 approximately 50 microm-thick glass membrane chemically modified with a 3-cyanopropyldimethylchlorosi

281 erials composed of a functional protein core chemically modified with a dense shell of oligonucleotid

282 rescence of the enzyme glucose oxidase (GOx) chemically modified with a fluorescein derivative (FS) a

283 GMT was chemically modified with a hydrolysable linker, and subs

284 study, a 2-helix small protein, MUT-DS, was chemically modified with a metal chelator, 1,4,7,10-tetr

285 by intramolecular CT states when the NNI is chemically modified with an electron donor.

286 The azide group can be chemically modified with biotin for detection, affinity

287 embly of two sets of 5 nm gold nanoparticles chemically modified with DNA bearing complementary stick

288 PEDF chemically modified with fluorescein retained the capaci

289 rein, a carbon-paste electrode (CPE) that is chemically modified with gold nanoparticles (nAu) was fa

290 stals made of 470 nm silica spheres that are chemically modified with hydrocarbon, giving enhanced vo

291 Hyaluronic acid was chemically modified with hydroxyethyl methacrylate to fo

292 eported to date represent actin complexed or chemically modified with molecules that prevent its poly

293 A carbon-paste electrode chemically modified with multiwalled carbon nanotubes wa

294 n number and length vary, and lipid A can be chemically modified with phosphoethanolamine, aminoarabi

295 , benzonaphthyridine (BZN) TLR7 agonists are chemically modified with phosphonates to allow adsorptio

296 internal surfaces of the microchannels were chemically modified with polyethyleneimine (PEI), which

297 Multi-walled carbon nanotubes (MWCNTs) is chemically modified with pyrroloquinoline quinone glucos

298 The purified protein was then chemically modified with the biocompatible moiety retina

299 Paper fibers were chemically modified with thiol ligands to immobilize CdS

300 rge surface areas, high stability and can be chemically modified with various functional groups.