ライフサイエンスコーパス: chemokine CXCL12

1 inducing ligand, and IL-6) and PC attracting chemokines (CXCL12).

2 th inflammatory chemokines (CCL5) and homing chemokines (CXCL12).

3 helium and transmigration in response to the chemokine CXCL12.

4 long-lasting trails that are enriched in the chemokine CXCL12.

5 rylation and migration after exposure to the chemokine CXCL12.

6 ng cells under a chemotactic gradient of the chemokine CXCL12.

7 f a non-HS-binding mutant of the homeostatic chemokine CXCL12.

8 on of the B cell chemotactic response to the chemokine CXCL12.

9 uited partly through tumor generation of the chemokine CXCL12.

10 ACKR3) functions as a scavenger receptor for chemokine CXCL12, a molecule that promotes multiple step

11 Mechanistically, we showed that the chemokine CXCL12 acted downstream of DCLK1 in cultured M

12 al Cell, Li et al. report that nerve-derived chemokine Cxcl12 (also known as SDF-1), acting through i

13 ates interleukin (IL)-6 and IL-8 but not the chemokine CXCL12, an important mediator with inflammator

14 accompanied by elevated tumor levels of the chemokine CXCL12 and infiltration by proangiogenic TIE2-

15 The chemokine CXCL12 and its cognate receptor CXCR4 regulate

16 The chemokine CXCL12 and its G protein-coupled receptors CXC

17 The chemokine CXCL12 and its receptor CXCR4 are expressed wi

18 Signals mediated by the chemokine CXCL12 and its receptor CXCR4 are involved in

19 The chemokine CXCL12 and its receptor CXCR4 have many functi

20 The chemokine CXCL12 and its receptor CXCR4 play a key role

21 The interaction between the chemokine CXCL12 and its receptor CXCR4 plays a pivotal

22 ich depends upon the interaction between the chemokine CXCL12 and its receptor CXCR4.

23 The chemokine CXCL12 and its two cognate receptors-CXCR4 and

24 Chemokine CXCL12 and receptor CXCR4 control multiple ste

25 cranial bone injury model, we identified the chemokine Cxcl12 and the Hedgehog family ligands Shh and

26 The chemokine-CXCL12 and its receptor, CXCR4, have recently

27 The role of the chemokines CXCL12 and CCL11 in fibrocyte migration was i

28 ates chemotaxis to the lymph node-associated chemokines CXCL12 and CCL21.

29 th ET-2 also increased chemotaxis toward the chemokines CXCL12 and CCL21.

30 st cancer cells expressing CXCR7 accumulated chemokines CXCL12 and CXC11 present at concentrations <1

31 In vitro migration toward the chemokines CXCL12 and CXCL13 and cell-cell interactions

32 -plastin (LPL) in B cell motility toward the chemokines CXCL12 and CXCL13 and the lipid chemoattracta

33 and increased CLL cell migration toward the chemokines CXCL12 and CXCL13.

34 xcessively and desensitize improperly to the chemokines CXCL12 and CXCL13.

35 Chemokines CXCL12 and CXCL16, important for trophoblast

36 ted in-vitro migration of DCs towards key DC chemokines, CXCL12 and CCL19.

37 sels control T cell exit from tumors via the chemokine CXCL12, and intratumoral antigen encounter tun

38 ce growth factor c-Kit ligand (Kitl/SCF) and chemokine CXCL12, and were thought to be static and sess

39 cer cells, cancer cells were coated with the chemokine, CXCL12, and the FAP(+) CAF was the principal

40 The chemokine receptor CXCR4 and its chemokine CXCL12 are involved in normal tissue patternin

41 es indicate that polarized expression of the chemokine CXCL12 at the BBB prevents leukocyte extravasa

42 The chemokine CXCL12 augments collagen-induced platelet aggr

43 The alarmin HMGB1 and the chemokine CXCL12, both released in the microenvironment,

44 Chemokine Cxcl12 but not its receptor, Cxcr4, was expres

45 enitors and endothelial cells expressing the chemokine CXCL12, but whether a separate niche instructs

46 Constitutive expression of the chemokine CXCL12 by bone marrow stromal cells provides a

47 The chemokine CXCL12 (C-X-C motif ligand 12) and its signali

48 , and migration in response to tissue homing chemokines (CXCL12, CXCL13).

49 s showed a defect in migration toward the GC chemokines, CXCL12, CXCL13, and CCL19.

50 o from major shifts in the lymphocyte-homing chemokines, CXCL12, CXCL13, and CCL19/21, as shown by qu

51 ligand (CXCL)10 (CXCR3) and the homeostatic chemokine CXCL12 (CXCR4).

52 alpha4beta7 complex was functional since the chemokine CXCL12 enhanced the adhesion of FDCP-mix to im

53 e we assess the physiological sources of the chemokine CXCL12 for HSC and restricted progenitor maint

54 echanism of BBB compromise is not known, the chemokine CXCL12 has been implicated as a molecular comp

55 e investigated signaling by the ASC-secreted chemokine CXCL12 in a mouse allograft model of PCa and i

56 ell responses, and suppresses the protective chemokine CXCL12 in CNS tissue.

57 The role of the chemokine CXCL12 in disease pathogenesis was confirmed i

58 these studies was to define the role for the chemokine CXCL12 in regulating E-cadherin during collect

59 uate in antiphase with the expression of the chemokine CXCL12 in the bone marrow microenvironment.

60 eg cells, enables Treg cell migration toward chemokine CXCL12 in the tumor microenvironment, and may

61 mised migration to the BM in vivo and to the chemokine CXCL12 in vitro, as well as increased expressi

62 ng in Cajal-Retzius cells was reduced by the chemokine CXCL12, indicating the existence of a direct C

63 sistently, stimulation of CLL cells with the chemokine CXCL12 induced RhoA but not Rac1 activation, w

64 e provide evidence that MLK3 is required for chemokine (CXCL12)-induced invasion of basal breast canc

65 The chemokine CXCL12 induces prolonged focal adhesion kinase

66 The chemokine CXCL12 is a developmental molecule known to or

67 The chemokine CXCL12 is a highly conserved peptide that regu

68 The chemokine CXCL12 is chemoattractive toward axonal growth

69 The chemokine CXCL12 is highly expressed throughout the CNS

70 The pleiotropic chemokine CXCL12 is involved in diverse physiological an

71 omains of bone-marrow microvessels where the chemokine CXCL12 is particularly abundant.

72 We show that a chemokine, Cxcl12, is an attractant for interneurons dur

73 n inhibits L- and P-selectin, as well as the chemokine CXCL12, leading to leukocytosis.

74 last niches via selective loss of fibroblast chemokine CXCL12 led to late brain-specific innate infla

75 In this study, we show that the chemokine CXCL12-mediated signaling contributes to corre

76 Correlating with activation by the chemokine CXCL12 of T-lymphocyte attachment to alpha4bet

77 study, we focused on CXCR4, which binds the chemokine CXCL12 or stromal cell-derived factor-1, a che

78 stromal cell-derived factor 1 (SDF-1), a CXC chemokine (CXCL12), plays a critical role in monocyte/ma

79 The chemokine CXCL12 promotes glioblastoma (GBM) recurrence

80 In the CNS, the chemokine CXCL12 promotes remyelination via CXCR4 activa

81 Here, we report that the chemokine CXCL12 recoups both cognitive performance and

82 The chemokine CXCL12 regulates multiple cell functions, incl

83 nd progenitor cells (HSPC), attracted by the chemokine CXCL12, reside in specific niches in the bone

84 The chemokine CXCL12 (SDF-1) and its cognate receptor CXCR4

85 ctin polymerization and migration toward the chemokines CXCL12 (SDF-1) and CCL25 in vitro.

86 The CXC chemokine CXCL12/SDF-1alpha interacts with its receptor

87 responses included the up-regulation of the chemokine CXCL12/SDF1 and down-regulation of its recepto

88 Here we show a peculiar role for the chemokine CXCL12 secreted in early PDAC and for its rece

89 emonstrated that epigenetic silencing of the chemokine CXCL12 sensitizes breast and colon cancer cell

90 The chemokine CXCL12 signals through its receptor CXCR4 to i

91 The chemokine CXCL12 (stromal cell-derived factor 1 (SDF-1))

92 CXCR4, a receptor for the chemokine CXCL12 (stromal-cell derived factor-1alpha), i

93 n chemotaxis of ILK-deficient T cells to the chemokines CXCL12 (stromal cell-derived factor [SDF]-1al

94 CD26/DPPIV has the ability to cleave the chemokine CXCL12/stromal cell-derived factor 1alpha (SDF

95 +/+) animals and higher plasma levels of the chemokine CXCL12/stromal cell-derived factor-1 (SDF-1) w

96 on process is stimulated by the inflammatory chemokine CXCL12, suggesting a regulatory role for endog

97 , investigators have focused on the use of a chemokine, CXCL12, the only identified ligand for CXCR4,

98 ons of dasatinib on signaling induced by the chemokine CXCL12 through its' receptor CXCR4, which is h

99 CXCR4 binds the chemokine CXCL12 to regulate cellular processes and medi

100 ng thymic beta-selection, the binding of the chemokine CXCL12 to the receptor CXCR4 on thymocytes pro

101 polarization, and reduced expression of the chemokine Cxcl12 Under shear stress in culture, Dach1 ov

102 factor [epidermal growth factor (EGF)] and a chemokine (CXCL12), using orthotopic floor-of-mouth mode

103 s are repelled by high concentrations of the chemokine CXCL12 via a concentration-dependent and CXCR4

104 The chemokine CXCL12, via its receptor CXCR4, promotes incre

105 Furthermore, the homeostatic chemokine CXCL12 was up-regulated by LIGHT and LTalpha1b

106 apsulated SC-beta cells; an immunomodulatory chemokine, CXCL12, was incorporated into clinical grade

107 s CXCR7, binds and degrades the constitutive chemokine CXCL12, which also binds the canonical recepto

108 venges and degrades the stem cell recruiting chemokine CXCL12, which is essential for proper embryoni

109 for their early migration in the nose is the chemokine CXCL12, which is expressed in the embryonic na

110 Interaction of the chemokine CXCL12 with its receptor CXCR4 promotes neuron

111 kine receptor 3 (ACKR3) are activated by the chemokine CXCL12 yet evoke distinct cellular responses.