ライフサイエンスコーパス: chemokine receptor

1 ogical regulation is illustrated by the CCR5 chemokine receptor.

2 nce for epigenetic regulation of an atypical chemokine receptor.

3 and inducing a conformational change in the chemokine receptor.

4 are not universal across monocyte-expressed chemokine receptors.

5 st interactions between RAMPs and nearly all chemokine receptors.

6 e currently few approved medicines targeting chemokine receptors.

7 using the QTY code to design detergent-free chemokine receptors.

8 ies and challenges to find novel ligands for chemokine receptors.

9 gent for imaging both human and murine CXCR4 chemokine receptors.

10 PI3Kgamma is activated by G protein-coupled chemokine receptors.

11 , a known regulatory variant in the atypical chemokine receptor 1 (ACKR1) gene.

12 we test aspects of this model with C-C motif chemokine receptor 1 (CCR1) and several chemokine ligand

13 ed death receptor 1-ligand 1 (PD1-L1), CxxxC chemokine receptor 1 (Cx3CR1), CCR7, and CCR9.

14 membrane-bound psoriasis-associated atypical chemokine receptor 2 (ACKR2) binds, internalizes and deg

15 Atypical chemokine receptor 2 (ACKR2) is a chemokine decoy recept

16 Atypical chemokine receptor 2 (ACKR2) is a chemokine-scavenging r

17 Activation of CC chemokine receptor 2 (CCR2) by its cognate chemokine lig

18 C-C chemokine receptor 2 (CCR2) is a key driver of monocyte/

19 CC chemokine receptor 2 (CCR2) is a part of the chemokine r

20 -C motif chemokine ligand 13 and a C-C motif chemokine receptor 2 (CCR2) were significantly higher in

21 Signaling between the CC chemokine receptor 2 (CCR2) with its ligand, monocyte ch

22 CC chemokine receptor 2 (CCR2)-/-embryos display an identic

23 mation through activation of endothelial CXC Chemokine Receptor 2 (CXCR2) and production of endotheli

24 C-X-C motif chemokine receptor 2 (CXCR2) is a chemokine receptor kno

25 r aim was to discover the role of IL-17, CXC chemokine receptor 2 (CXCR2) ligands, and cancer-associa

26 HT)-dependent activation of spinal CXC Motif Chemokine Receptor 2 (CXCR2) may support TBI-related noc

27 t the monocyte chemoattractant protein-1/C-C chemokine receptor 2 axis plays a critical role in the p

28 Monocyte chemoattractant protein-1 and C-C chemokine receptor 2 were increased in the tissues from

29 stinct subsets of tissue-resident CCR2- (C-C chemokine receptor 2) and CCR2+ macrophages orchestrate

30 The monocyte chemoattractant protein-1/CCR2 (chemokine receptor 2) axis plays an important role in ab

31 Wild-type animals that received C-C chemokine receptor 2-deficient bone marrow had a complet

32 C-C chemokine receptor 2-deficient recipients of GFP-express

33 rapidly mobilized upon inflammation in a CC-chemokine receptor 2-dependent manner, and the nonclassi

34 to image the recruitment of proinflammatory chemokine receptor 2-positive (CCR2+) cells in multiple

35 CC chemokine receptors 2 (CCR2) and 5 (CCR5) are involved i

36 Here, we find inflammatory-related CC-chemokine-receptor 2 (Ccr2) expression in non-hematopoie

37 emokine receptor type 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are part of the class A che

38 pecifically, RAMP3 association with atypical chemokine receptor 3 (ACKR3) diminishes adrenomedullin (

39 However, atypical chemokine receptor 3 (ACKR3) does not appear to couple t

40 XC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3), both members of the GPCR s

41 Atypical chemokine receptor 3 (ACKR3), previously known as C-X-C

42 in disease have put a spotlight on atypical chemokine receptor 3 (ACKR3).

43 the two CXCL12 receptors, CXCR4 and atypical chemokine receptor 3 (ACKR3)/CXCR7, as promising therape

44 ine receptor type 4 (CXCR4) and the atypical chemokine receptor 3 (ACKR3/CXCR7) are class A G protein

45 Chemokine receptors CXCR4 and atypical chemokine receptor 3 (ACKR3/CXCR7) are highly expressed

46 The C-C chemokine receptor 3 (CCR3) is dramatically upregulated

47 LP), Charcot-Leyden crystal (CLC), C-C motif chemokine receptor 3 (CCR3), and CPA3.

48 CXC chemokine receptor 3 (CXCR3)-expressing B cells were enr

49 neating the recognized functions of atypical chemokine receptor 3 and CXCR4 in CXCL12 signaling is ce

50 CXCR4 and atypical chemokine receptor 3 are two oncogenic G protein-coupled

51 Lymphocytes expressing C-X-C chemokine receptor 3 CD8 significantly correlated with O

52 activated blood basophils overexpressing C-C chemokine receptor 3.

53 Here, we identified a role for host atypical chemokine receptor 4 (ACKR4) in controlling intratumor T

54 The C-C chemokine receptor 4 (CCR4) is broadly expressed on regu

55 The two CXC-type chemokine receptors, CXC chemokine receptor 4 (CXCR4) and atypical chemokine rece

56 Here, we report that C-X-C motif chemokine receptor 4 (CXCR4) and hedgehog pathways coope

57 CXC chemokine receptor 4 (CXCR4) blockade promotes T cell tu

58 C-X-C chemokine receptor 4 (CXCR4) is a transmembrane chemokin

59 The chemokine receptor CXC-chemokine receptor 4 (CXCR4) is a transmembrane receptor

60 The C-X-C motif chemokine receptor 4 (CXCR4) is attractive for targeted

61 The CXC-motif chemokine receptor 4 (CXCR4) represents a promising targ

62 reported on our experience with C-X-C-motif chemokine receptor 4 (CXCR4)-directed radioligand therap

63 l dominant gain-of-function mutations in CXC chemokine receptor 4 (CXCR4).

64 tor 4 and the chemokine receptor C-X-C motif chemokine receptor 4 (CXCR4).

65 nd 12 (CXCL12) and its receptor, C-X-C motif chemokine receptor 4 (CXCR4).

66 ization among known GPCR homodimers: the CXC chemokine receptor 4 and sphingosine-1-phosphate recepto

67 We observe that CXC chemokine receptor 4 and sphingosine-1-phosphate recepto

68 CXCR4 (C-X-C motif chemokine receptor 4) has been implicated in human cardi

69 t promotes atherosclerosis through CXC-motif chemokine receptor-4 (CXCR4).

70 3100, a competitive inhibitor of C-X-C motif chemokine receptor-4, has been found to be a rapid mobil

71 ells through the downregulation of C-C motif chemokine receptor 5 (CCR5) in T cells and CD4 in both T

72 se downregulated the expression of C-C motif chemokine receptor 5 (CCR5) in T cells and CD4 in both T

73 C-C chemokine receptor 5 (CCR5) is a chemokine receptor belo

74 C-C chemokine receptor 5 (CCR5) is a key drug target for hum

75 C-C chemokine receptor 5 (CCR5) plays an essential role in H

76 Chemokine receptor 5 (CCR5), human leukocyte antigen (HL

77 We show that the C-X-C motif chemokine receptor 5 (CXCR5)-C-X-C motif chemokine ligan

78 ogenic cells in a C-C chemokine ligand 5/C-C chemokine receptor 5-dependent manner.

79 n)-17 and the chemokine receptor CXCR (C-X-C chemokine receptor)-6.

80 tation of LXA(4) identified modulation of CC-chemokine receptor 7 (CCR7) and sphingosine 1- phosphate

81 ve previously demonstrated that the atypical chemokine receptor ACKR2 contributes to the control of d

82 entify robust RAMP interaction with atypical chemokine receptors (ACKRs), which function to establish

83 coupled to differential occupancy of cognate chemokine receptors across the cell.

84 xpression of immune-related pathways such as chemokine receptor activity, chemotaxis and cytokine bio

85 Under the influence of CXCR1 and CXCR2 chemokine receptor agonists and other chemotactic factor

86 Understanding how this atypical chemokine receptor allele increases serum markers of inf

87 Thus, differential trafficking of two chemokine receptors allows coordination of antagonistic

88 Differences in the chemokine receptor and beta1 integrin expression profile

89 e and MZ B cells differ in the expression of chemokine receptors and activation markers.

90 d a hyperinflammatory phenotype enriched for chemokine receptors and homing molecules that facilitate

91 While several chemokine receptors and ligands control multiple stages

92 ices, and altered mRNA expression of related chemokine receptors and ligands.

93 Chemokine receptors and their associated ligands are inv

94 tionship of HIV persistence to expression of chemokine receptors and their chemokines in blood (n = 4

95 xpressed higher levels of CCR6, a CNS-homing chemokine receptor, and exhibited a regulatory profile c

96 larly reflected in the expression of CCR2, a chemokine receptor, and in the expression of Rae-1, a li

97 cs, suppressed matrix metalloproteinases and chemokine receptors, and the induction of CXCL11-CXCR3 a

98 Chemokine receptors are also involved in multiple pathol

99 However, chemokine receptors are imperative for guiding cells out

100 Chemokine receptors are of great interest as they play a

101 emphasizes the importance of chemokines and chemokine receptors as regulators of bone remodeling.

102 cancer models identified CXCR7, an atypical chemokine receptor, as one of the most upregulated genes

103 Targeting a specific chemokine/receptor axis in atherosclerosis remains chall

104 Chemokine receptors belong to the class A of G protein-c

105 C-C chemokine receptor 5 (CCR5) is a chemokine receptor belonging to the G protein-coupled re

106 otential new class of therapeutics targeting chemokine receptors belonging to the class of G protein-

107 erapies and point to a multifaceted role for chemokine receptor binding in promoting HIV-1 entry.

108 FI-binding affinity and the stoichiometry of chemokine receptor binding to trimeric Env.

109 (ECM) organization, mast cell activation, CC-chemokine receptor binding, circulating immunoglobulin c

110 s and models promote unique understanding of chemokine receptor biology, including the interpretation

111 t with small interfering RNA or inhibitor of chemokine receptors blocked LSD1 inhibitor-enhanced CD8+

112 se viral receptors exhibit homology to human chemokine receptors, but some display constitutive activ

113 actor interferon regulatory factor 4 and the chemokine receptor C-X-C motif chemokine receptor 4 (CXC

114 of an anti-inflammatory cytokine and a decoy chemokine receptor can modulate inflammatory processes i

115 ltaT cells are recruited to the liver by C-C chemokine receptor (CCR) 2, CCR5, and nucleotide-binding

116 Also, CXCR4 forms heteromers with CC chemokine receptor (CCR) 2, CCR5, the Na(+)/H(+) exchang

117 lencing of a group of chemokine (CC/CXC) and chemokine receptor (CCR) mRNAs, thereby helping to resol

118 altered expression of the CCL20 receptor CC chemokine receptor (CCR)6, suggesting that Fpr2/3 regula

119 (IL-17, TNF-alpha, IL-9, and IFN-gamma) and chemokine receptors (CCR1, CCR2, CCR4, CCR5, CCR6, and C

120 ation of the expression of the gene encoding chemokine receptor Ccr2, a mediator of inflammation and

121 part due to low expression of the C-C motif chemokine receptor (CCR2) and the integrin Very Late Ant

122 flow cytometry to analyze the expression of chemokine receptors CCR3, CCR4, CCR5, CXCR3, and CRTh2,

123 The chemokine receptor CCR4 and its respective ligands, CCL1

124 ssing high levels of Th2 and Th17 cytokines, chemokine receptors CCR4 and CCR6, and the transcription

125 Chemokine receptor CCR5 correlates with functional CD8(+

126 The chemokine receptor CCR5 is a drug target to prevent tran

127 e primary receptor CD4 and coreceptor (e.g., chemokine receptor CCR5 or CXCR4) to allow viral entry b

128 imary receptor CD4 and a coreceptor (such as chemokine receptor CCR5) to fuse viral and target-cell m

129 fferentiation 4 receptors and one of the two chemokine receptors (CCR5 and CXCR4) to gain entry in hu

130 o-electron microscopy structure of the human chemokine receptor CCR6 bound to its endogenous ligand C

131 esters on the expression of the brain-homing chemokine receptor CCR6 in CD4 and CD8 T cells of patien

132 in transcriptional factor RORgammat, but not chemokine receptor CCR6, showed full rescue of the long-

133 ietin, and localization was dependent on the chemokine receptor CCR6.

134 Ligands for chemokine receptors CCR6 and CXCR2 are increased in both

135 Il17a), chemokines (Ccl2, Cxcl1, Cx3cl1) and chemokine receptors (Ccr6, Cxcr6, Cx3cr1) in livers of T

136 l for the induction of the key thymus-homing chemokine receptor - CCR6 on Tregs.

137 Among mice deficient in chemokine receptors, CCR6(-/-) mice had 120 copies/mug R

138 ells in a manner that was independent of the chemokine receptor CCR7 but sensitive to Gi protein-coup

139 from brain parenchyma is dependent upon the chemokine receptor CCR7.

140 Here, we analyzed the role of the CC-chemokine receptor CCR8 for the biological functions of

141 D4+ memory T cells expressing the gut-homing chemokine receptor CCR9 and found a reduced frequency of

142 In HCV, intrahepatic T cells express chemokine receptors (CCRs), including CXCR3, CXCR6, CCR1

143 ecific small molecule antagonist of the CCR6 chemokine receptor, CCX2553, was efficacious in reducing

144 Expression of the chemokine receptor chemokine C-X-C motif receptor 4 (CXC

145 f chemokine ligand 2 (CCL2) with an atypical chemokine receptor chemokine-binding protein 2 variant V

146 in melanoma microenvironment is supported by chemokine receptor/chemokine signaling.

147 However, very few structures of a native chemokine-receptor complex have been solved.

148 tetramer(+) ) CD4(+) T cells expressing the chemokine receptor CRTh2, we assessed the impact of Cat-

149 ligand discovery and design studies based on chemokine receptor crystal structures and homology model

150 hort review summarizes the available data on chemokine receptor crystal structures, discusses the num

151 tional signature including expression of the chemokine receptor CX3CR1, pro-inflammatory cytokines, a

152 e appearance in the AGM was dependent on the chemokine receptor Cx3cr1.

153 immunity through interactions with the human chemokine receptor CX3CR1.

154 The chemokine receptor CXC-chemokine receptor 4 (CXCR4) is a

155 The two CXC-type chemokine receptors, CXC chemokine receptor 4 (CXCR4) an

156 T cells express IL (interleukin)-17 and the chemokine receptor CXCR (C-X-C chemokine receptor)-6.

157 The CXC chemokine ligand (CXCL) 12/CXC chemokine receptor (CXCR) 4 axis represents a well-estab

158 ivation and early signaling steps of the CXC chemokine receptor (CXCR) 4 in response to its natural l

159 anied by downregulation of the CXCL8-binding chemokine receptors CXCR1 and CXCR2 on human neutrophils

160 gy in mice through combined targeting of the chemokine receptor CXCR2 and the very late antigen 4 (VL

161 erosis (MS).IMPORTANCE Signaling through the chemokine receptor CXCR2 in oligodendroglia is important

162 R-treated mice displayed lower levels of the chemokine receptor CXCR2, consistent with a reduced abil

163 expression of the chemokine CXCL2 to induce chemokine receptor CXCR2-dependent diurnal changes in th

164 , which recruited neutrophils expressing the chemokine receptor CXCR2.

165 -derived, T(FH1)-like cells that express the chemokine receptor Cxcr3 and produce both the T(H)1 cyto

166 Finally, chemokine receptor CXCR3 is upregulated in the expanded

167 und that tumor-bearing mice deficient in the chemokine receptor CXCR3 responded poorly to anti-PD-1 t

168 s, defined by the absence or presence of the chemokine receptor CXCR3.

169 We also demonstrate that the chemokine receptor Cxcr3.2 is expressed in a distinct su

170 sed TCR Vbeta 5.1, 16, 20, and 22 as well as chemokine receptors CXCR3, CCR6, CCR4, and CCR9.

171 duced chemokine (CXCL10) production, reduced chemokine receptor (CXCR3) and adhesion molecule (LFA-1)

172 We found that two chemokine receptors, CXCR3 and CCR10, are upregulated on

173 This tissue expresses the chemokine receptor Cxcr4 and is guided by the chemokine

174 t roles in development, cancer, and HIV, the chemokine receptor CXCR4 and its ligand CXCL12 have been

175 The chemokine receptor CXCR4 and its ligand CXCL12 regulate

176 ophils to upregulate their expression of the chemokine receptor CXCR4 and to release neutrophil extra

177 ole of a sulfation site in the activation of chemokine receptor CXCR4 by its ligand.

178 Inhibition of the chemokine receptor CXCR4 in combination with blockade of

179 s that focal adhesion kinase-1 (FAK) and the chemokine receptor CXCR4 promote epithelial repair mecha

180 The chemokine receptor CXCR4 regulates fundamental processes

181 as reversed by AMD3100, an antagonist of the chemokine receptor CXCR4 that mediates Treg cell recruit

182 rleukin 7 receptor (IL7R) interacts with the chemokine receptor CXCR4 to recruit BCR-ABL1 and JAK kin

183 oping thymocytes, and the interaction of the chemokine receptor CXCR4 with its ligand adheres TCR-uns

184 The chemokine receptor CXCR4, a G protein-coupled receptor (

185 e induction of the glucocorticoid-responsive chemokine receptor CXCR4, and selective blockade of CXCR

186 vation of focal adhesion kinase (FAK) by the chemokine receptor CXCR4, facilitating chemotaxis.

187 hods to an activation-like transition of the chemokine receptor CXCR4, observed during accelerated MD

188 Chemokine receptors CXCR4 and atypical chemokine recepto

189 Two chemokine receptors, CXCR4 and CX3CR1, were broadly expr

190 Tfh are identified by high expression of the chemokine receptor CXCR5 and the inhibitory molecule PD-

191 ologous activation of PKC by stimulating the chemokine receptor CXCR5 with its ligand, CXCL13, also m

192 unctionalized with CXCL13-the ligand for the chemokine receptor CXCR5, which is frequently found on B

193 ithin lymphoid tissues express low levels of chemokine receptor (CXCR5), thus limiting their ability

194 ammadelta T cells express high levels of the chemokine receptor CXCR6 and seed meninges shortly after

195 The recently discovered chemokine receptor CXCR7 and its ligand stromal cell-der

196 The chemokine receptor CXCR7, also known as ACKR3, is a seve

197 The atypical chemokine receptor D6/ACKR2 is expressed on apoptotic PM

198 In summary, we identify a novel chemokine receptor-dependent mechanism by which ILC2s ar

199 ting the function of GPCRs, and particularly chemokine receptors, draws high interest.

200 tor-based strategies are not established for chemokine receptors due to their discontinuous architect

201 CXCR2 is a chemokine receptor expressed on oligodendroglia that has

202 CXCR3, CXCR5, CXCR6, and CCR2, respectively, chemokine receptors expressed by all of the immune cell

203 so show that all detergent-free QTY-designed chemokine receptors, expressed in Escherichia coli, bind

204 ncer showing the ability of RhoA to suppress chemokine receptor expression in breast tumor cells.

205 Chemokine receptor expression on CD4+ T cells was determ

206 transcription factors E2A and HEB disorders chemokine receptor expression on developing thymocytes t

207 e lentiviral protein Nef, and not changes to chemokine receptor expression or function, is the domina

208 lating TCR complex components and modulating chemokine receptor expression to promote dissemination o

209 Activation marker and chemokine receptor expression was determined for beta7-d

210 CD4(+) /CD8(+) phenotype and chemokine receptor expression were analyzed by flow cyto

211 oss blunted eosinophil migration and altered chemokine receptor expression, both in vivo and ex vivo.

212 vely screen for RAMP interactions within the chemokine receptor family and identify robust interactio

213 Thus, RAMP association with chemokine receptor family members represents a molecular

214 chemokine receptor 2 (CCR2) is a part of the chemokine receptor family, an important class of therape

215 mportant light on combinatorial inflammatory chemokine receptor function and highlight Ccr2 as the pr

216 Modulation of chemokine receptor function is a very promising approach

217 oubts remain that CXCR4 represents a classic chemokine receptor, functions assigned to ACKR3/CXCR7 ra

218 is is similarly affected by mutations in the chemokine receptor gene, cxcr4b, suggesting it is a pote

219 ibody ligands targeting GPCRs outside of the chemokine receptor group.

220 To date, no atypical chemokine receptor has been crystallized, which makes li

221 hough the blockade of various chemokines and chemokine receptors has yielded promising results in pre

222 ects through collaboration with inflammatory chemokine receptors (iCCRs).

223 have a less mature phenotype and a distinct chemokine-receptor imprint indicative of skin-homing.

224 The ability to study chemokine receptors in aqueous solution without detergen

225 Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on a

226 f the individual and combinatorial roles for chemokine receptors in the inflammatory process.

227 suggest similar functions for other atypical chemokine receptors in the placenta and indicate that de

228 fficking (through the inhibition of specific chemokine receptors) into skin can positively affect tum

229 mokine receptor 4 (CXCR4) is a transmembrane chemokine receptor involved in growth, survival, and dis

230 This atypical chemokine receptor is overexpressed in numerous cancer t

231 ACKR3, as an atypical chemokine receptor, is generally reported to not activat

232 -X-C motif chemokine receptor 2 (CXCR2) is a chemokine receptor known for its role during inflammatio

233 cilitates the prediction of the structure of chemokine receptor-ligand complexes that have not been c

234 ctivation of Tnfa and its receptors or major chemokine receptor-ligand subsets persisted in the long

235 perior to intravaginal instillation of CXCR3 chemokine receptor ligands or TLR 3, 7, and 9 agonists t

236 tuberculosis infection that is regulated by chemokine receptors likely reflects the cumulative effec

237 e we test whether co-expression of the decoy chemokine receptor M3, that can scavenge inflammatory ch

238 T cells had no changes in chemokine receptor mRNA half-life but instead had lower

239 patients with PDACs with high levels of the chemokine receptors of CXCR3 and CCR7 had increased freq

240 s regulate the ordered expression pattern of chemokine receptors on developing thymocytes, and the in

241 , CXCL9, G-CSF, GM-CSF, VEGF, and M-CSF) and chemokine receptors on MDSCs (CCR1, CCR5, and CXCR2).

242 elope glycoprotein (Env) of HIV-1 to CD4 and chemokine receptors on target cells triggers refolding o

243 , is regulated by chemokines, which activate chemokine receptors on the leukocytes.

244 c CD4(+) T cells, nor in their expression of chemokine receptors or memory phenotype, was observed.

245 gene profiling studies to identify chemokine-chemokine receptor pairs that are involved in tumor lymp

246 y associated with differential expression of chemokine receptors, particularly CXCR5.

247 phocytes compartmentalize according to their chemokine receptor pattern and subsequently migrate towa

248 Ex vivo flow cytometry was used to assess chemokine receptor profiles of B cells in blood, cerebro

249 ghly conserved intracellular binding site in chemokine receptors provides a new avenue for the design

250 Interestingly, TKIs modulated the chemokine receptor repertoire of immune cells.

251 ss CXCR5 (C-X-C chemokine receptor type 5, a chemokine receptor required for homing to GCs) and expan

252 ltered T cell gene and protein expression of chemokine receptors S1PR1 and CCR7, and their master reg

253 binding domain called smallpox virus-encoded chemokine receptor (SECRET) domain.

254 chestrating cell migration, it is vital that chemokine receptor signaling is tightly regulated to ens

255 gnaling combined with inadequate homeostatic chemokine receptor signaling.

256 evasins that function through inhibition of chemokine-receptor signaling in the host.

257 HIV gp120 determine viral interactions with chemokine receptors; specifically, HIV-X4 viruses intera

258 ructures, substantial efforts in the area of chemokine receptor structural biology could dramatically

259 es, discusses the numerous applications from chemokine receptor structures that can enhance the daily

260 In parallel, chemokine receptor structures with small molecules revea

261 t differential ligand-induced trafficking of chemokine receptors such as Cxcr1 and Cxcr2 orchestrates

262 While IAV induced some activation and chemokine receptor switching in cord blood mDC, RSV did

263 e type of inflammation, making the chemokine/chemokine receptor system a key point of the immune resp

264 ts will aid the rational design of selective chemokine-receptor targeting small molecules and biologi

265 .772G>A) in ACKR3, which encodes an atypical chemokine receptor that binds CXCL12 and functions as a

266 ctal cancer by impairing the function of the chemokine receptors that mediate the intratumoral accumu

267 reflects the cumulative effects of multiple chemokine receptors that mostly promote but that can als

268 port the design of 2 detergent-free chimeric chemokine receptors that were experimentally unattainabl

269 Here we quantify the contributions of these chemokine receptors to the migration and entry rate of T

270 se the AT1R and certain other GPCRs (such as chemokine receptors) to adopt conformations that are cap

271 quency of MO, T cells, and expression of C-C chemokine receptor type 2 (Ccr2) and C-C chemokine recep

272 C-C chemokine receptor type 2 (CCR2) antagonist and clodrona

273 C-C chemokine receptor type 2 (CCR2) is expressed on monocyt

274 the heart is largely populated by CCR2- (C-C chemokine receptor type 2) macrophages of embryonic desc

275 wo G protein-coupled receptors (GPCRs) C-X-C chemokine receptor type 4 (CXCR4) and atypical chemokine

276 The C-X-C motif chemokine receptor type 4 (CXCR4) and the atypical chemo

277 features, including overexpression of C-X-C chemokine receptor type 4 (CXCR4) and upregulation of pl

278 iously demonstrated that antagonism of C-X-C chemokine receptor type 4 (CXCR4) by plerixafor (AMD3100

279 was correlated with the number of dermal C-C chemokine receptor type 4(+) T helper type 2 cells, IL-1

280 phil aging, were antagonized by CXCR4 (C-X-C chemokine receptor type 4) and regulated the outer topol

281 ding of cholesterol to the G protein coupled chemokine receptor type 4, and the identification of per

282 hage colony-stimulating factor and the C-X-C chemokine receptor type 4.

283 ibitor T20 (Fuzeon, enfuvirtide) and the C-C chemokine receptor type 5 (CCR5) blocker maraviroc (Selz

284 C-C chemokine receptor type 2 (Ccr2) and C-C chemokine receptor type 5 (Ccr5) in the livers of patien

285 The C-C chemokine receptor Type 5 (CCR5) is a key receptor for h

286 C-C chemokine receptor type 5 (CCR5) serves as a co-receptor

287 tance of the G-protein-coupled receptor, C-C chemokine receptor type 5 (CCR5), in human disease since

288 V)-specific CD8 T cells express CXCR5 (C-X-C chemokine receptor type 5, a chemokine receptor required

289 eceptor 3 (ACKR3), previously known as C-X-C chemokine receptor type 7 (CXCR7), has emerged as a key

290 CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes,

291 The specific chemokine receptors utilized by Th1 cells to migrate int

292 ys were activated, and specific cytokine and chemokine receptors were up-regulated in CSF memory B ce

293 ulate various immune responses by activating chemokine receptors which belong to the G protein-couple

294 BMC)-derived CD8 T cells to express the CCR9 chemokine receptor, which induces preferential homing of

295 ramework that can potentially be extended to chemokine receptors, which also typically interact with

296 Tregs reveal an enhancement in graft-homing chemokine receptors, which may be partly responsible for

297 Chemokines bind to membrane-spanning chemokine receptors, which signal through G proteins and

298 CXCR4 is one of only three chemokine receptors with a US Food and Drug Administrati

299 integration of new structural information on chemokine receptors with extensive structure-activity re

300 -up production of detergent-free QTY variant chemokine receptors with tunable functionality for vario