ライフサイエンスコーパス: chemoreceptor

1 the dissociation constant (K(d))(1-6) of the chemoreceptor.

2 sensitivity are not known for any eukaryotic chemoreceptor.

3 pH-sensitive, as expected for a respiratory chemoreceptor.

4 d acid, indicating that it is a bifunctional chemoreceptor.

5 each other and with CheA independent of the chemoreceptors.

6 gered by activation of peripheral or central chemoreceptors.

7 timulation of the kinase by certain types of chemoreceptors.

8 the mechanism of transmembrane signaling in chemoreceptors.

9 aling in the cytoplasmic domain of bacterial chemoreceptors.

10 ple chemotaxis systems and a large number of chemoreceptors.

11 le effect on the CO2/H(+)-sensitivity of RTN chemoreceptors.

12 stent with their role as central respiratory chemoreceptors.

13 es CO2/H(+) responsiveness of other putative chemoreceptors.

14 ated with highly duplicated families such as chemoreceptors.

15 mini that send opposing signals in bacterial chemoreceptors.

16 poxaemia and acidosis in peripheral arterial chemoreceptors.

17 s act with high specificity on their cognate chemoreceptors.

18 hrough highly cooperative, ordered arrays of chemoreceptors.

19 which does not rely on previously identified chemoreceptors.

20 e) and peripheral (primarily O(2)-sensitive) chemoreceptors.

21 both been proposed to be central respiratory chemoreceptors.

22 al and interdependent feedback regulation by chemoreceptors.

23 ontrolling chemotaxis, utilizes the other 23 chemoreceptors.

24 We propose that chemoreceptors achieve long-range allosteric control of

25 ild-type (WT) mice, and smaller responses to chemoreceptor activation when anesthetized.

26 that are predicted to operate downstream of chemoreceptor activation.

27 ould not be attributed to changes of central chemoreceptor activity (hypocapnia prevailed); altered a

28 at the cellular level that ACh increases RTN chemoreceptor activity by a CO2/H(+) independent mechani

29 nstantaneous increase or decrease of central chemoreceptor activity by activating or inhibiting the r

30 stive heart failure (CHF), carotid body (CB) chemoreceptor activity is enhanced and is associated wit

31 muscarinic receptor activation to changes in chemoreceptor activity may provide new potential therape

32 The effects of ACh on RTN chemoreceptor activity were also blunted by inhibition o

33 w are associated with increased carotid body chemoreceptor activity.

34 nstantaneous increase or decrease of central chemoreceptor activity.

35 of fluorescent tracer onto carotid body for chemoreceptor afferents or onto aortic depressor nerve f

36 ansmembrane (TM) helices of Escherichia coli chemoreceptors alone are sufficient to mediate clusterin

37 l complex perturbs the polar localization of chemoreceptors, alters cell motility, and affects chemot

38 ial to maintain the correct alignment of the chemoreceptor and kinase binding sites of CheW.

39 owards As(III), however, the related As(III) chemoreceptor and regulatory mechanism remain unknown.

40 , a model organism for chemotaxis that has 5 chemoreceptors and a single chemosensory pathway, Pseudo

41 two species, Salmonella genomes contain some chemoreceptors and an additional protein, CheV, that are

42 ylation of the cytosolic signaling domain of chemoreceptors and are among the core proteins of chemos

43 A CheW had essentially the same affinity for chemoreceptors and CheA, cells expressing the mutant pro

44 Like other bacteria, H. pylori uses chemoreceptors and conserved chemotaxis proteins to phos

45 ives autophosphorylation control inputs from chemoreceptors and in turn regulates the flux of signali

46 m of neuromodulation mediated by the carotid chemoreceptors and involving both the sympathetic and pa

47 a has also evolved an expanded repertoire of chemoreceptors and odorant binding proteins, many associ

48 ASK-2, GPR4), synaptic input from peripheral chemoreceptors and signals from astrocytes.

49 an exquisitely high density of 3 x 10(5) GC chemoreceptors and subnanomolar ligand affinity provide

50 protein that mediates the association of the chemoreceptors and the CheA kinase in a ternary signalin

51 largely redundant abilities to interact with chemoreceptors and the CheA kinase, and both similarly a

52 VAH involves plasticity in arterial chemoreceptors and the CNS [e.g. nucleus tractus solitar

53 The relevant chemoreceptors and the neuronal circuits responsible for

54 rtion of RTN neurons are central respiratory chemoreceptors and there is mounting evidence for bioche

55 show that AgTRPA1 is an inherent thermo- and chemoreceptor, and analogous to what has been reported f

56 sponse gains physiological, and carotid body chemoreceptors are driven by a wide range of O2 and/or C

57 Central chemoreceptors are highly sensitive neurons that respond

58 gests that the principal central respiratory chemoreceptors are located within the retrotrapezoid nuc

59 Bacterial chemoreceptors are long helical proteins that consist of

60 SRB chemoreceptors are not essential for sperm navigation un

61 The principal peripheral chemoreceptors are the carotid bodies (CBs) and alterati

62 Transmembrane chemoreceptors are widely present in Bacteria and Archae

63 graphy, we explore V. cholerae's cytoplasmic chemoreceptor array and establish that it is formed by p

64 ns may be used to provide flexibility in the chemoreceptor array formation.

65 to their environment through a transmembrane chemoreceptor array whose structure and function have be

66 McpA, which forms a part of the chemoreceptor array, acts as a validation structure by b

67 Across bacterial species, chemoreceptor arrays (both transmembrane and soluble) ar

68 The best-studied bacterial chemoreceptor arrays are membrane-bound.

69 Using cryo-ET, we reveal that Td chemoreceptor arrays assume an unusual arrangement of th

70 These findings confirm that chemoreceptor arrays do not undergo large structural cha

71 During bacterial chemotaxis, transmembrane chemoreceptor arrays regulate autophosphorylation of the

72 redundant for formation of the higher order chemoreceptor arrays that are known to form via CheA-Che

73 s of nearly all the individual components of chemoreceptor arrays, ECT has revealed the mesoscale inf

74 st common applications has been to bacterial chemoreceptor arrays, ECT's contributions to this field

75 elf-assembly both of flagellar motors and of chemoreceptor arrays.

76 ligomerization patterns observed for related chemoreceptors, as higher loading of Aer dimers into nan

77 ine activity and CO2/H(+)-sensitivity of RTN chemoreceptors, as well as to dissect the signalling pat

78 em consists of large arrays of transmembrane chemoreceptors associated with a dedicated histidine kin

79 typical example is the assembly of bacterial chemoreceptors at cell poles.

80 In rat arterial chemoreceptors, background potassium channels play an im

81 c responses to apnoea result from changes of chemoreceptor, baroreceptor or lung stretch receptor inp

82 ur study, could not be attributed to altered chemoreceptor, baroreceptor, or pulmonary stretch recept

83 o suggest that >75% of these Nmb neurons are chemoreceptors because they are strongly activated by hy

84 Thus, chemoreceptors behave as coupled units, in which dynamic

85 acterial cell (e.g. type IV pili, holdfasts, chemoreceptors), but perhaps none show so many distinct

86 ns are both candidates for central CO(2) /pH chemoreceptors, but it is not known how interactions bet

87 These results show that ACh activates RTN chemoreceptors by a CO2/H(+) independent mechanism invol

88 Stimulation of peripheral chemoreceptors by acute hypoxia causes an increase in mi

89 Activation of central chemoreceptors by CO2 increases arterial blood pressure

90 Activation of central chemoreceptors by CO2 increases sympathetic nerve activi

91 tments elicited, at least partly, by central chemoreceptors (CCRs) and the carotid bodies (CBs).

92 nergic Phox2b-expressing central respiratory chemoreceptors (CCRs), is the site of such plasticity.

93 to peripheral control of breathing, central chemoreceptors (CCs) are considered a dominant mechanism

94 (TRPA1), and that HNO activates the sensory chemoreceptor channel TRPA1 via formation of amino-termi

95 tron cryotomography to image the cytoplasmic chemoreceptor cluster in Rhodobacter sphaeroides and Vib

96 in curved agar microchambers, and find that chemoreceptor cluster localization is highly sensitive t

97 of the protein complex and does not rely on chemoreceptor clustering, as was previously shown for Es

98 the system's components, it is not clear how chemoreceptor clusters are reliably targeted to the cell

99 li Tol-Pal complex restricts mobility of the chemoreceptor clusters at the cell poles and may be invo

100 utes to the segregation and retention of Tsr chemoreceptor clusters at the cell poles.

101 equired to maintain the polar positioning of chemoreceptor clusters in Escherichia coli.

102 interaction is required to polarly localize chemoreceptor clusters.

103 al worms contain compact and highly diverged chemoreceptor complements and lineage-specific ion chann

104 The carotid body (CB) is a major arterial chemoreceptor containing glomus cells whose activities a

105 reliable, sensitive, measure of the carotid chemoreceptor contribution to tonic sympathetic nervous

106 ring REM sleep because fR is no longer under chemoreceptor control and thus could explain why central

107 ting opposite effects on central respiratory chemoreceptors (CRCs).

108 We engineered chemoreceptor cytoplasmic regions to assume a trimer of

109 Further assessments of single chemoreceptor deletion strains revealed that an mcpX del

110 nflammatory network was abrogated by carotid chemoreceptor denervation and by pharmacological blockad

111 ugh much is known about the structure of the chemoreceptors, details of the receptor dynamics and the

112 mplexes contain two trimers of transmembrane chemoreceptor dimers, each trimer binding a coupling pro

113 ing of chemo-effectors to the membrane-bound chemoreceptor dimers.

114 We used this model to explore chemoreceptor discharge patterns in response to electric

115 presence of CheR, a variety of mutant serine chemoreceptors displayed up to 40-fold enhanced detectio

116 tive and reliable means of quantifying tonic chemoreceptor-driven levels of sympathetic nervous syste

117 y of treatment approaches aimed at lessening chemoreceptor-driven sympathetic overactivity are now un

118 factory receptor neurons (ORNs) that express chemoreceptors encoded by large gene families, including

119 Genomic analyses revealed a putative chemoreceptor-encoding gene, mcp, located in the arsenic

120 tion and genetic sex to dynamically modulate chemoreceptor expression and influence the feeding-versu

121 ts--somatic sex, age, and feeding status--on chemoreceptor expression highlights sensory function as

122 n Brugia malayi, an etiological agent of LF, chemoreceptor expression patterns correspond to distinct

123 For several chemoreceptor families, we show divergent numbers of gen

124 oducing planarians, and identified an orphan chemoreceptor family member, ophis, that controls differ

125 We find that chemoreceptor family size is correlated with the presenc

126 that the two sensory inputs alter different chemoreceptor features.

127 discuss the potential relevance of this dual chemoreceptor feedback to cardiorespiratory abnormalitie

128 x chemosensory network, which consists of 26 chemoreceptors feeding into four chemosensory pathways.

129 opose to rename Tlp11 as CcrG, Campylobacter ChemoReceptor for Galactose.

130 essary in addition to plasticity of arterial chemoreceptors for normal VAH.

131 an approach for designing boronic acid-based chemoreceptors for the recognition and quantification of

132 fragments of normally transmembrane E. coli chemoreceptors form similar sandwiched structures in the

133 interacts with specific domains of CheA and chemoreceptors from an orthologous group exemplified by

134 ructure, but have some affinity bias towards chemoreceptors from different orthologous groups.

135 nding molecular mechanisms that regulate RTN chemoreceptor function may identify therapeutic targets

136 le of KCNQ channels in the regulation of RTN chemoreceptor function, and suggest that these channels

137 e also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairo

138 rophic shifts in insects are associated with chemoreceptor gene loss as recently evolved ecologies sh

139 udes alternative alleles of srx-44, a second chemoreceptor gene that modifies pheromone sensitivity.

140 Here we show that peripheral chemoreceptors generate aberrant signaling that contribu

141 esults and genome-wide evidence suggest that chemoreceptor genes may be preferred sites of adaptive v

142 current model of O2 sensing by carotid body chemoreceptor (glomus) cells is that hypoxia inhibits th

143 In bacterial chemotaxis, each chemoreceptor has multiple methylation sites that are re

144 chemotaxis have long been speculated, such a chemoreceptor has not been demonstrated.

145 Various classes of chemoreceptors have been hypothesized to play essential

146 Peripheral arterial chemoreceptors have been isolated to the common carotid

147 Peripheral arterial chemoreceptors have been located previously in the carot

148 is recently appreciated that many bacterial chemoreceptors have ligand-binding domains (LBD) of the

149 tive neurotransmitters associated with these chemoreceptors have not yet been described.

150 ion of both peripheral (hypoxia) and central chemoreceptors (hypercapnia).

151 ince the 1960s to harbor central respiratory chemoreceptors [i.e., acid-activated neurons that regula

152 selective ablation of the carotid body (CB) chemoreceptors improves cardiorespiratory control and su

153 The GC chemoreceptor in sea urchin sperm can decode chemoattrac

154 We found that ACh activates RTN chemoreceptors in a dose-dependent manner (EC50 = 1.2 mu

155 plex chemosensory systems with corresponding chemoreceptors in bacterial and archaeal genomes.

156 report the identification of a novel type of chemoreceptors in human keratinocytes, the olfactory rec

157 tify the curvature-dependent localization of chemoreceptors in live cells by artificially deforming g

158 he carotid bodies (CBs), the main peripheral chemoreceptors in mammals, to hypoxia and CO(2)-induced

159 pecies also contain an additional cluster of chemoreceptors in their cytoplasm.

160 lial cells (NECs), which are putative oxygen chemoreceptors, increased significantly when these cells

161 of the core signaling unit and suggest that chemoreceptors indirectly sequester the kinase and subst

162 cerebral spinal fluid to minimize peripheral chemoreceptor input.

163 Instead, our data indicate that chemoreceptors interact with components of the Tol-Pal c

164 e that hyperaddition is the dominant form of chemoreceptor interaction in quiet wakefulness when the

165 Our model of bilayer-chemoreceptor interactions also helps to explain the obs

166 we introduce a biophysical model of bilayer-chemoreceptor interactions, which allows us to quantify

167 For many bacteria, the repertoire of chemoreceptors is large, suggesting they possess a broad

168 species, the presence of a larger number of chemoreceptors is likely to contribute to the ability of

169 nsion monitored by the peripheral (arterial) chemoreceptors is not sensitive to regional CNS differen

170 The mechanism of oxygen sensing in arterial chemoreceptors is unknown but has often been linked to m

171 s, suggests a series of "gateway" states for chemoreceptor lattice assembly, and provides a simple me

172 dicts the observed honeycomb architecture of chemoreceptor lattices as well as the observed relative

173 -mediated interactions can yield assembly of chemoreceptor lattices at very dilute trimer concentrati

174 The signaling response of the observed chemoreceptor lattices is remarkable for its extreme sen

175 mple mechanism for the localization of large chemoreceptor lattices to the cell poles.

176 ractions in the assembly and architecture of chemoreceptor lattices.

177 imer that had not been observed in bacterial chemoreceptor LBDs.

178 Hypersensitivity of the carotid chemoreceptor leading to sympathetic nervous system acti

179 n HFpEF and that acute activation of central chemoreceptors leads to increases of cardiac sympathetic

180 oattractants sensed by only one of the major chemoreceptors leads to inversion of the thermotactic re

181 trolling a histidine kinase as a function of chemoreceptor ligand occupancy.

182 nd-binding domain (LBD) of the transmembrane chemoreceptor MCP2201, which governs chemotaxis to citra

183 In this report, we demonstrated that the chemoreceptor MCP2901 from Comamonas testosteroni CNB-1

184 The carotid chemoreceptor mediates the ventilatory and muscle sympat

185 was proposed to result from stochasticity in chemoreceptor methylation, and it is believed to enhance

186 oplasmic fragment (CF) and within the intact chemoreceptor; modulation of its dynamics is thought to

187 s into the molecular signaling mechanisms of chemoreceptor networks.

188 osensitive bristle neurons and sweet-sensing chemoreceptor neurons.

189 on afferent information from baroreceptors, chemoreceptors, nociceptors, and circulating hormones, a

190 e regulate expression of the food-associated chemoreceptor odr-10, contributing to plasticity in food

191 pect of this state is high expression of the chemoreceptor odr-10.

192 re the olfactory circuit by regulating a key chemoreceptor, odr-10, in the AWA neurons.

193 on of this Gly residue in the high-abundance chemoreceptors of E. coli and Salmonella enterica sugges

194 o derive homologies with peripheral arterial chemoreceptors of other vertebrates.

195 ve (CSN) conveys electrical signals from the chemoreceptors of the carotid bifurcation to the central

196 Innate immune chemoreceptors of the formyl peptide receptor (Fpr) fami

197 t is not known whether LITE-1 functions as a chemoreceptor or photoreceptor.

198 The carotid body (CB) is an arterial chemoreceptor organ located in the carotid bifurcation a

199 In all previously described species, chemoreceptors organize into a hexagonal (P6 symmetry) e

200 Bacterial chemoreceptors organize into large clusters at the cell

201 g activity even in the absence of peripheral chemoreceptor oxygen sensing.

202 AI-2 binds to the dCACHE domain of chemoreceptors PctA and TlpQ of Pseudomonas aeruginosa,

203 ensory pathways in P. aeruginosa utilize one chemoreceptor per pathway, whereas the fourth pathway, w

204 th in vivo ectopic expression of vomeronasal chemoreceptors, PhOTseq identified the complete combinat

205 Carotid chemoreceptors play a seminal role in the pathogenesis o

206 e find that modulated expression of a single chemoreceptor plays a key role in naturally occurring va

207 ss low-to-moderate levels of Nmb and display chemoreceptor properties.

208 cals in their environment with transmembrane chemoreceptor proteins.

209 the pH response from 5-HT neurons and other chemoreceptors rather than as pH sensors themselves.

210 regarding how regulation of vascular tone in chemoreceptor regions contributes to respiratory behavio

211 ive sequence analysis specifically targeting chemoreceptor regions involved in pathway interactions r

212 that CO(2)/H(+) dilates arterioles in other chemoreceptor regions, thus demonstrating CO(2)/H(+) vas

213 s.SIGNIFICANCE STATEMENT Central respiratory chemoreceptors regulate arterial PCO2 by adjusting lung

214 Respiratory chemoreceptors regulate breathing in response to changes

215 understand the molecular mechanisms by which chemoreceptors regulate social behaviors, we investigate

216 by which CO(2)/H(+) -sensitive neurons (i.e. chemoreceptors) regulate breathing in response to change

217 t responses were mediated by the Tsr and Tar chemoreceptors, respectively.

218 cally in a way that enhances the respiratory chemoreceptor response.

219 However, the chemoreceptor responsible for sensing gastric injury has

220 electron cryo-tomography have revealed that chemoreceptors self-assemble into extended honeycomb lat

221 Central respiratory chemoreceptors sense changes in CO2/H(+) and initiate th

222 A sensory adaptation system that tunes chemoreceptor sensitivity enables motile Escherichia col

223 Because the sequences of chemoreceptor signaling domains are highly conserved, it

224 otation and piston-like motion for bacterial chemoreceptor signaling.

225 electron cryotomography to visualize mutant chemoreceptor signalling arrays in well-defined kinase a

226 ctivation is the default output state of the chemoreceptor signalling domain and that attractant stim

227 ned activation of RTN, CBs and other central chemoreceptors.SIGNIFICANCE STATEMENT Hypercapnia and hy

228 lostery in core complexes assembled with two chemoreceptor species, each recognizing a different liga

229 nd hypoxia and hypercapnia episodes activate chemoreceptors stimulating autonomic reflex responses.

230 ve discharge was attenuated and responses to chemoreceptor stimulation and noxious stimulation were b

231 reflexes are arousal state dependent whereas chemoreceptor stimulation produces arousal.

232 of Escherichia coli CheY protein transduces chemoreceptor stimulation to a highly cooperative flagel

233 We asked if the type of carotid body (CB) chemoreceptor stimulus influenced the ventilatory gain o

234 and CheW share the same binding spot on the chemoreceptor structure, but have some affinity bias tow

235 omodimer, similar to previously well-studied chemoreceptors such as Tar and Tsr of Escherichia coli.

236 le during swarming, and mutants lacking this chemoreceptor swarm faster and produce colonies with mor

237 re additional, sometimes purely cytoplasmic, chemoreceptor systems.

238 amics of the periplasmic domain of aspartate chemoreceptor Tar dimer and its conformational changes w

239 ackbones in the cytoplasmic domain of intact chemoreceptor Tar homodimers inserted into lipid bilayer

240 ic domains of the Escherichia coli aspartate chemoreceptor Tar(Ec) are both strongly influenced by re

241 ith opposite pH responses from two different chemoreceptors (Tar and Tsr).

242 hia coli, the ratio of the two most abundant chemoreceptors, Tar/Tsr, has become the focus of much at

243 (NTS), where afferent endings from arterial chemoreceptors terminate.

244 as relays from other central and peripheral chemoreceptors than as CO(2) sensors.

245 at includes alternative alleles of srx-43, a chemoreceptor that inhibits exploration through its acti

246 ch utilizes specialized sensory organs and a chemoreceptor that is tuned to recognize the bacteria.

247 This is the first report of a chemoreceptor that mediates QACs taxis through direct bi

248 Unlike other chemoreceptors that act in males to inhibit male-male in

249 Although the existence of chemoreceptors that bind to aromatic attractants and sub

250 linking the CheA kinase to certain types of chemoreceptors that cannot be effectively accommodated b

251 The carotid bodies (CB) are peripheral chemoreceptors that classically respond to hypoxia by in

252 Drosophila contains diverse families of chemoreceptors that detect odors, tastants, pheromones,

253 Olfactory sensory neurons (OSNs) are chemoreceptors that establish excitatory synapses within

254 Many bacteria contain cytoplasmic chemoreceptors that lack sensor domains.

255 Carotid bodies (CBs) are chemoreceptors that monitor and register changes in the

256 of the carotid body (peripheral respiratory chemoreceptors) that stimulate breathing when oxygenatio

257 in stimulating the primary autonomic oxygen chemoreceptors, the carotid bodies, in parasympathetic-m

258 Bacterial chemoreceptors, the histidine kinase CheA, and the coupl

259 nvestigated the roles of a critical class of chemoreceptors, the odorant receptors (ORs), from the po

260 Here we show that the classical chemoreceptor TlpA of Bacillus subtilis does not localiz

261 ponse is largely controlled by the bacterial chemoreceptor TlpB, and the main attractant emanating fr

262 ure of dCACHE LBD of the Helicobacter pylori chemoreceptor TlpC.

263 chemotactic motility that requires the TlpB chemoreceptor to sense signals generated by gastric epit

264 The firing response of RTN chemoreceptors to ACh was mimicked by a muscarinic recep

265 fluenced the ventilatory gain of the central chemoreceptors to CO2 .

266 that enabled us to unambiguously link all 26 chemoreceptors to four pathways.

267 uced incomplete and uncertain assignments of chemoreceptors to pathways.

268 tor mosquito, Anopheles gambiae, depend upon chemoreceptors to respond to volatiles emitted from a ra

269 ter pylori requires a noncanonical cytosolic chemoreceptor transducer-like protein D (TlpD) for effic

270 ed membranes arises from the curved shape of chemoreceptor trimer of dimers.

271 In common with other membrane proteins, chemoreceptor trimers are expected to deform the surroun

272 assemble into extended honeycomb lattices of chemoreceptor trimers with a well-defined relative orien

273 well as the observed relative orientation of chemoreceptor trimers, suggests a series of "gateway" st

274 e that curvature sensitivity is intrinsic to chemoreceptor trimers-of-dimers, and results from confor

275 ontribute to cooperativity among neighboring chemoreceptor trimers.

276 crucially on cooperative interactions among chemoreceptor trimers.

277 emonstrate that DHMA is sensed by the serine chemoreceptor Tsr and that the chemotaxis response requi

278 DHMA is sensed by the serine chemoreceptor Tsr, and the attractant response requires

279 e of the homodimeric Escherichia coli serine chemoreceptor (Tsr) interacts with an adjoining four-hel

280 E402 and R404 of the Escherichia coli serine chemoreceptor, Tsr, appear to form a salt bridge that sp

281 d the mobility of the polar localized serine chemoreceptor, Tsr, labeled by the fluorescent protein V

282 Localization of the chemoreceptors was independent of phospholipid compositi

283 n the ventilatory CO2 sensitivity of central chemoreceptors was studied in seven awake dogs with vasc

284 Using mutants lacking individual chemoreceptors, we found that only TlpB was required for

285 Chemoreceptors were inserted in Nanodiscs, which rendere

286 While several chemoreceptors were rigorously linked to specific pathwa

287 O2 titrated) and central (7% CO2 and 93% O2) chemoreceptors were stimulated for 3 minutes.

288 This contrasts with most chemoreceptors where signals propagate along the protein

289 , the vast majority, are central respiratory chemoreceptors, whereas Nmb-high neurons likely have oth

290 active during the stimulation of peripheral chemoreceptors, which also activates adrenergic C1 cells

291 The genes encoding the Tar, Tsr, and Aer chemoreceptors, which mediate chemotaxis to a broad spec

292 y underwent an ancestral loss of Trg and Tap chemoreceptors, which sense sugars, dipeptides, and pyri

293 ys that control this directionality comprise chemoreceptors, which, along with an adaptor protein (Ch

294 We further identify a chemoreceptor with an unusual domain architecture, DosM,

295 moreflexes are primarily determined by brain chemoreceptors with intrinsic pH sensitivity likely driv

296 In humans, excitation of peripheral chemoreceptors with systemic hypoxia causes hyperventila

297 dditional adaptor for accommodating specific chemoreceptors within the chemotaxis signaling complex.

298 her modulators, controls the activity of RTN chemoreceptors without interfering with the mechanisms b

299 ypothesized that denervation of the CB (CBD) chemoreceptors would reduce SNA, reduce apnoea and arrhy

300 atiation while minimally affecting brainstem chemoreceptor zones triggering nausea.