ライフサイエンスコーパス: chemoselective

1 ese TMP salts were demonstrated to be highly chemoselective.

2 te experimental data showing that it is less chemoselective.

3 reaction is rapid, operationally simple, and chemoselective.

4 Additionally, the chemoselective 1,4-reduction of the enone products provi

5 Furthermore, this allows for a chemoselective 1,5-HAT over competing direct cyclization

6 This has enabled a chemoselective 1,6-HAT over a competing 1,5-HAT.

7 n with photoredox catalysis allows for mild, chemoselective access to a wide array of related structu

8 Driven by the unmet need to develop chemoselective access to boron chemotypes, we report her

9 The chemoselective acetoxylation of the epsilon-C-H bond was

10 Especially, the BDG-aided chemoselective acetoxylation of the remote epsilon-C(sp(

11 -catalyzed, bidentate directing group-aided, chemoselective acetoxylation/substitution of remote epsi

12 Chemoselective acidic hydrolysis of sulfonamides with tr

13 The chemoselective activation and coupling of C-terminal pep

14 Chemoselective activation of amide carbonyl functionalit

15 -amino acid selenoesters which are effective chemoselective acylating reagents.

16 etic derivatization of starting material via chemoselective acylation of the l-ornithine alpha-amino

17 )-containing peptides catalyzed enantio- and chemoselective acylations and phosphorylations of multip

18 th microscopic investigation that probes the chemoselective addition of Ag to Pt-Fe3O4 heterodimer se

19 inert atmospheres in toxic organic solvents, chemoselective addition of organolithium reagents to non

20 Highly chemoselective addition of Schwartz's reagent to widely

21 a non-natural amino acid (NNAA) followed by chemoselective albumin conjugation to prolong therapeuti

22 tion that normally poses major challenges in chemoselective, aliphatic C-H functionalization.

23 The chemoselective allylic oxidation of ester-functionalized

24 es by a pyridinium dichromate (PDC)-mediated chemoselective allylic oxidation.

25 amily of iron catalysts capable of promoting chemoselective alpha-oxidation of a range of ethers with

26 Notably, chemoselective amidation of aliphatic amines takes place

27 Steric constraints of the catalyst allow for chemoselective amidation of primary amines in the presen

28 aBH(4) reduction of a chiral oxime ether and chemoselective amidation of the resulting unprotected pi

29 Co(II)-based metalloradical system features chemoselective amination of allylic C-H bonds and is com

30 C, and D, through a route fueled by several chemoselective and carefully orchestrated steps.

31 lar nitrene transfer reactions that are both chemoselective and flexible for aziridination or C-H ins

32 s fast, operationally simple, high yielding, chemoselective and functional group tolerant method.

33 h repeat unit, which is enabled by perfectly chemoselective and highly syndiospecific coordination po

34 A highly chemoselective and one-pot NH and O transfer is develope

35 Multiple chemoselective and redox-economic functional group inter

36 proach outlined in this protocol enables the chemoselective and regioselective late-stage silylation

37 ealed that confined nickel(II) sites enabled chemoselective and reversible binding to acetylene throu

38 that peptide fragments can be exchanged by a chemoselective and reversible native chemical ligation (

39 mproved reagents, while the demonstration of chemoselective and scalable iPP functionalization to rea

40 r preparing lanthionine peptides by a highly chemoselective and stereochemically controlled procedure

41 yne substrates are found to undergo a highly chemoselective and stereoselective domino Pauson-Khand a

42 The reaction is both chemoselective and syn-selective, making it complementar

43 The method is chemoselective and tolerates a wide range of reducible f

44 ess screen, we show that this methodology is chemoselective, and functional group tolerant.

45 reports the first general method for rapid, chemoselective, and modular functionalization of serine

46 igosaccharide synthesis including selective, chemoselective, and orthogonal strategies is demonstrate

47 The reaction is efficient, chemoselective, and pH/redox neutral.

48 mer-polymer click reaction, achieving rapid, chemoselective, and quantitative coupling at room temper

49 Discovery of this broadly applicable, chemoselective, and solvent-versatile reagent should all

50 gy involves low catalyst loadings, is highly chemoselective, and tolerates a wide variety of function

51 photoredox catalysis, and radical chemistry, chemoselective approaches have emerged as a means to imp

52 d, among them the most recent strategies for chemoselective arene metalation on peptides.

53 useful toolkit of Cu-based catalysts for the chemoselective arylation of a wide-range of nucleophiles

54 clamp motif (Phe-Cys-Pro-Phe) for regio- and chemoselective arylation of cysteine in ribosomally prod

55 Notably, chemoselective arylation of diazo compounds over other e

56 al C-H abstraction/rebound, as observed with chemoselective base metals such as iron.

57 er as a mechanism towards enabling site- and chemoselective bioconjugation.

58 further method development in the context of chemoselective, bioorthogonal labeling.

59 The identification of fast, chemoselective bond-forming reactions is one of the majo

60 for a range of organic reactions, including chemoselective borylation, silylation and amination of b

61 Also, Ag-mediated, completely chemoselective Br displacement from 2S leads to a range

62 ones was achieved with Grignard reagents via chemoselective C(O)-N bond cleavage.

63 -known reaction and enables an unprecedented chemoselective C(sp(2))-Ar sigma-bond insertion of the a

64 floxacin has been developed, which employs a chemoselective C-acylation step that precludes the need

65 Moreover, this chemoselective C-C coupling reaction with stereodefined

66 )(2)RuCl(2)] as an effective precatalyst for chemoselective C-H hydroxylation of C(sp(3))-H bonds and

67 This combines a highly site-selective and chemoselective C-H hydroxylation with a mild, functional

68 The method can be applied to the chemoselective C-H oxygenation of benzylic, allylic, and

69 methanol can be used as a C1 source and the chemoselective C-methylation of nitriles is achieved.

70 Highly chemoselective C-S cross-coupling was achieved versus co

71 This chemoselective carbene insertion into -NH bond over -COO

72 to Dha, promoted by zinc and copper, enables chemoselective carbon-carbon bond formation.

73 trate the application of these catalysts for chemoselective carbon-halogen bond activation to achieve

74 Palladium-catalyzed chemoselective carbonylation of aminophenols with iodoar

75 ation, easily accessible starting materials, chemoselective cascade process, synthetically useful yie

76 A general and chemoselective catalytic alkylation of nitriles using a

77 Disclosed is a mild, scalable, and chemoselective catalytic cross-dehydrogenative C-H bond

78 Chemoselective catalytic oxidation of beta-O-4 linkages

79 The reaction provides a chemoselective catalytic synthesis of 2H-indazoles, 2H-b

80 The reaction provides a chemoselective catalytic synthesis of alpha-acyloxy este

81 by chlorotrimethysilane is described for the chemoselective chlorination of polyprenoids.

82 The chemoselective cleavage of a six-membered aromatic ring

83 Chemoselective cleavage of the Phen group was performed

84 he sustained-release nascent-HBr enabled the chemoselective cleavages of acid-sensitive orthogonal fu

85 Chemoselective conditions unmasked the thioester functio

86 g molecules is also affected by geometry and chemoselective confinement via matrix binding.

87 issue assemblies through chemistry involving chemoselective conjugation and release.

88 hydroxy ketone to a diketone was followed by chemoselective conversion of the methyl ketone in this s

89 Here, we report an efficient enantio- and chemoselective copper hydride catalyzed semireduction of

90 the less reactive allylphenyl carbonates as chemoselective copper-hydride elimination is faster with

91 ing the stability of adducts formed from the chemoselective coupling of oxaziridine and methionine th

92 e coupling of a dibromobenzene, as well as a chemoselective coupling of phenyl bromides in the presen

93 This report describes the chemoselective coupling of polyfluoroarenes with aryl ge

94 SCl, and a mild reductant can participate in chemoselective cross-coupling with aryl iodides using a

95 neous electrophile control allows sequential chemoselective cross-couplings in a single operation in

96 systems and provides a unifying strategy for chemoselective CuAAC ligations in multialkyne/azide syst

97 ional design of carbonylacrylic reagents for chemoselective cysteine bioconjugation.

98 offer the greatest potential for regio- and chemoselective dehydrogenation of alkyl groups and alkan

99 A new, fast, mild and chemoselective deprotection method to cleave p-methoxybe

100 We have synthesized chemoselective derivatives of the tarantula toxin guangx

101 onium thiocyanate as the thiocyanate source, chemoselective difunctionalization of alkenes has been d

102 Highly chemoselective direct reduction of primary, secondary, a

103 f an activating Weinreb carboxamide, further chemoselective elaboration leads to the efficient format

104 However, the chemoselective enzymatic re-acylation of glucosamine der

105 Ps, the PRO-functionalized Pt NPs are highly chemoselective even at 100% conversion.

106 g of aryl iodides with aldehydes occurs in a chemoselective fashion in the presence of protic functio

107 mportant beta-aryl ketone intermediates in a chemoselective fashion.

108 uinolinones, and quinolinols in a regio- and chemoselective fashion.

109 (OTf)2), N-fluoro-2-methylbenzamides undergo chemoselective fluorine transfer to provide the correspo

110 The polymerization by 1 is perfectly chemoselective for all four polar divinyl monomers, proc

111 The reaction is fully chemoselective for amides even in the presence of esters

112 This reaction is chemoselective for aromatic aldehydes, as an aliphatic a

113 The method was shown to be highly chemoselective for cysteine over other potentially nucle

114 lization"), which is shown to be exquisitely chemoselective for terminal alkenes, leaving even termin

115 The CyClick chemistry is highly chemoselective for the N-terminus of the peptide with a

116 s onto diblock-copolymer-coated surfaces are chemoselective for the placement of thiol and alcohol nu

117 The key sequence features a highly chemoselective formamide activation that triggered a Vil

118 e Hg complex that drives the reaction to the chemoselective formation of 2,5-dihydrofurans.

119 Rhodium(I) and a new SDP ligand promote chemoselective formation of a cyclohex-3-enecarbaldehyde

120 cytosine nucleosides with TMSN(3) led to the chemoselective formation of triazoles via Cu(I)-catalyze

121 e addition and transmetalation, this enables chemoselective formation of two C-C bonds in a single op

122 to the assay is the utilization of a highly chemoselective Friedlander reaction that captures and si

123 Cell surface tailoring of chemoselective functional groups was achieved by a lipos

124 up in prepared structures allows for further chemoselective functionalization/post-synthetic transfor

125 ron products is demonstrated through several chemoselective functionalizations.

126 ive functional group, the reaction is highly chemoselective giving the dichloromethyl derivative.

127 or reactivity have led to the development of chemoselective glycosylation reactions and the reactivit

128 approach to HS and DS oligosaccharides using chemoselective glycosylation which relies on a disarmed

129 nthesis of type I LacNAc oligosaccharides by chemoselective glycosylation.

130 yl-linked disaccharide donors and acceptors, chemoselective glycosylations were investigated to obtai

131 Applications of 2S include chemoselective Grignard coupling, enabling the very shor

132 Chemoselective GxTX mutants conjugated to dendrimeric be

133 The stability of the borate unit allows chemoselective halogenation of the heteroaromatic ring,

134 Here we report a chemoselective, high-yielding alpha-aminonitrile ligatio

135 ][HBPh3], act as efficient catalysts for the chemoselective hydroboration of a wide range of aldehyde

136 r work up, 1 degrees and 2 degrees alcohols; chemoselective hydroboration of aldehydes over ketones i

137 Herein, a manganese-catalyzed chemoselective hydroboration of carboxylic acids has bee

138 droboration of styrenes as well as excellent chemoselective hydroboration of ketones over alkenes wer

139 ide catalyzed both intra- and intermolecular chemoselective hydroboration of nitriles and alkynes ove

140 Chemoselective hydroboration of nitriles over esters is

141 e consists of a C3 extension (allylation), a chemoselective hydroboration, an alkyne reduction, and a

142 ization/proto-desilylation sequence; and the chemoselective hydrogenation of a fully substituted dien

143 o can develop interesting performance in the chemoselective hydrogenation of alpha,beta-unsaturated o

144 rity affords a flexible means to control the chemoselective hydrogenation of aromatic aldehydes.

145 remarkably prohibited the hydrogenolysis in chemoselective hydrogenation of C=C bonds, leading to an

146 ytic hydrogenation, but their performance in chemoselective hydrogenation, particularly in heterogene

147 C-enabled tunable heterogeneous catalyst for chemoselective hydrogenation.

148 Chemoselective hydrolysis of the resulting 5,6-dihydro-1

149 A copper-catalyzed, chemoselective hydrometalation process enables the use o

150 In most cases, chemoselective hydrosilane reduction of the amide group

151 Notably, both intra- and intermolecular chemoselective hydrosilylation and hydroboration reactio

152 mbination was explored to achieve regio- and chemoselective hydroxylation.

153 efficient phosphine-catalyzed process via a chemoselective in situ phosphine oxide reduction.

154 Chemoselective interaction of aromatic enynes with Bu3Sn

155 based catalysts for the enantio-, regio- and chemoselective intermolecular alkylation of sp(3) C-H bo

156 Highly chemoselective intramolecular amination of propargylic C

157 odides in the presence of Mn2(CO)10 leads to chemoselective iodine atom abstraction and radical addit

158 ble indole-linked delta-lactams via a highly chemoselective iridium(I)-catalyzed reduction.

159 ess the pendant cyclopentenone, and a highly chemoselective lactam reduction delivered the natural pr

160 h native chemical ligation (NCL) and related chemoselective ligation approaches provide an elegant me

161 Chemoselective ligation of two 28-mer peptides has been

162 Using various combinations of sequential chemoselective ligation strategies, we go on to tag thes

163 Diversification of existing chemoselective ligations is required to efficiently acce

164 Key steps include the chemoselective lithiation of a 1-iodo-2-bromoolefin, the

165 midazolidinone, which is followed first by a chemoselective malonate PMB ester removal and then a Cur

166 We introduce a highly active and chemoselective manganese catalyst for the hydrogenation

167 gnized as valuable synthetic handles for the chemoselective manipulation of peptides and proteins.

168 acetate with acetylenic ketones occurs in a chemoselective manner in the presence of aliphatic or ar

169 amine linkages (secondary and tertiary) in a chemoselective manner under mild, biocompatible conditio

170 onalize the aromatic aminobenzoic acids in a chemoselective manner without implementing protection an

171 We took advantage of the chemoselective meso-functionalization of 2,3,5,6-tetrabr

172 The mechanism of a recently reported, highly chemoselective metal-free protocol of wide general appli

173 kyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonatio

174 Here, we report a strategy for chemoselective methionine bioconjugation through redox r

175 This highly chemoselective method can tolerate labile and reactive c

176 Herein, we report a facile, highly chemoselective method for transamidation of N-tert-butox

177 proach takes advantage of a nonenzymatic and chemoselective method to rapidly generate A2AR embedded

178 A non-enzymatic and chemoselective method to spontaneously generate phosphol

179 Here, we report a non-enzymatic and chemoselective methodology capable of autocatalytically

180 ires the development of a regioselective and chemoselective methodology.

181 acilitated greatly by recent developments in chemoselective methods for biomolecular modification.

182 A suite of flexible and chemoselective methods for the transition-metal-free oxi

183 Non-enzymatic and chemoselective methods to generate phospholipid membrane

184 Moreover, this protocol was tested for the chemoselective methylation of 4-aminobenzenesulfonamide.

185 A novel, organobase-catalyzed and highly chemoselective Michael-Michael-acetalization cascade is

186 catechols with aniline functional groups is chemoselective, mild, and rapid; however, the oxidativel

187 e soft-N-donors as effective complexants for chemoselective minor actinide extraction from used nucle

188 ting-group-free synthesis we demonstrate the chemoselective modification of 12 complex molecules that

189 Chemoselective modification of complex biomolecules has

190 Chemoselective modifications involving the alkenyl-B(pin

191 In this work, we present the first chemoselective N-alkylation of indoles in aqueous microd

192 stainable boron-based catalytic approach for chemoselective N-alkylation of primary and secondary aro

193 face syn to the ammonium moiety exclusively; chemoselective N-benzylation then provided either (1RS,2

194 d decarbonylative Heck reaction of amides by chemoselective N-C activation using N-acylsaccharins as

195 eck reaction of amides proceeding via highly chemoselective N-CO cleavage catalyzed by Pd(0) utilizin

196 theory (DFT) was used to explore the highly chemoselective nature of the catalytic hydrogenation of

197 The predictable and chemoselective nature of these transformations has led t

198 mino ketones with an aza-glycine equivalent, chemoselective nitrogen functionalization, and ring clos

199 tiary centers to be installed in a singular, chemoselective olefin difunctionalization.

200 ectroscopic and kinetic studies suggest that chemoselective organic transformations occur on site-iso

201 versatility of this masked diamine motif in chemoselective, orthogonal transformations.

202 iation of the radical cyclization product by chemoselective oxidation allows production of either the

203 Unusual regio- and chemoselective oxidation of aromatic amines hindered wit

204 ectrochemical process has been developed for chemoselective oxidation of primary alcohols in lignin t

205 RuCl3-NaIO4 reagent system were crucial for chemoselective oxidation of sulfide in the presence of a

206 sopropenyllithium TMEDA complex and a facile chemoselective oxidation with selenium dioxide.

207 The chemoselective oxidations of akuammicine leading up to t

208 Here we report a regioselective and chemoselective oxidative C(sp(3))-H methylation method t

209 ble bonds have been exploited to demonstrate chemoselective oxidative cleavage in substrates containi

210 A chemoselective oxidative cleavage of synthetic gracilioe

211 The reaction is chemoselective, oxidizing one alkene in the presence of

212 ross-couplings compared to halides, enabling chemoselective palladium- and nickel-catalyzed coupling

213 Here, we describe the chemoselective partial reduction of silyl-protected C6O6

214 This study also features regio- and chemoselective Pd(0)-catalyzed linear prenylation at C4

215 odified Hantzsch pyridine construction and a chemoselective Peng deprotection of a phenolic MOM ether

216 the presence of as little as 0.1 mol % of a chemoselective peptidic catalyst.

217 A highly chemoselective phenol cross-coupling reaction catalyzed

218 In this Communication, we develope a chemoselective photoacoustic sensor (LP-hCy7) composed o

219 An efficient chemoselective practical route to fully substituted thia

220 ronically challenging substrates in a highly chemoselective, practical, and rapid manner.

221 The chemoselective preparation of a variety of 2-S,N,O-subst

222 The chemoselective preparation of a variety of phosphoryl-su

223 boron atom of the boronic acids, leading to chemoselective primary amination.

224 c reactive handle on the NP is targeted by a chemoselective probe to enable its detection by mass spe

225 A reagent-controlled chemoselective process has been devised for the synthesi

226 obtained from readily available amides via a chemoselective process involving Tf2O-mediated amide cyc

227 with aldehydes, providing rapid, stable, and chemoselective protein bioconjugation.

228 tryptophan residue was shown to allow rapid, chemoselective protein modification using the azo-coupli

229 This general and highly chemoselective protocol delivers a broad range of arylet

230 e recent progress made in the development of chemoselective protocols for amide reduction and gives a

231 his end, we show that the recently developed chemoselective rapid azo-coupling reaction (CRACR) direc

232 allography and mass spectrometry confirmed a chemoselective reaction between the sulfonyl fluoride an

233 ss to the free amine products under mild and chemoselective reaction conditions.

234 The chemoselective reaction of donor/acceptor (D/A) and acce

235 Methods for the chemoselective reaction of either aliphatic amines or an

236 Chemoselective reactions are a highly desirable approach

237 In addition, chemoselective reactions are possible when there are phe

238 Here, we show that reversible chemoselective reactions can be harnessed to achieve non

239 Chemoselective reactions for amide bond formation have t

240 of our group's recent advances in exploring chemoselective reactions for stitching together lipid fr

241 efficiently constructed using two different chemoselective reactions that rely on the choice of reag

242 Here we demonstrate the potency of chemoselective reactions to accomplish sequence-controll

243 Combining chemoselective reactions with encoded amino acids has fa

244 of the past two decades, the demand for new chemoselective reactions with unique abilities, and thos

245 thus obtained has been confirmed in selected chemoselective reactions.

246 Such chemoselective reactivity is highly desirable for enabli

247 ehyde capture ligation that parlays the high chemoselective reactivity of aldehydes and amines to enf

248 y dramatic spectral shifts by leveraging the chemoselective reactivity of novel functional groups ins

249 aryl fluorosulfates studied thus far exhibit chemoselective reactivity toward Lys and, particularly,

250 3-aminophenylboronic acid (FITC-APBA) as the chemoselective recognition probe of sialylation product,

251 ssing the power of high stereo-, regio-, and chemoselective redox biocatalysts and enabling reactions

252 Chemoselective reduction and functionalization of these

253 ical transformations were required to permit chemoselective reduction and oxidation reactions.

254 , derivatization of bioactive molecules, and chemoselective reduction in the presence of other C-O bo

255 NHPtBu2] is the first efficient catalyst for chemoselective reduction of challenging unsaturated este

256 The protocol exploits the mild and highly chemoselective reduction of the amide and lactam functio

257 d via ring closing metathesis and subsequent chemoselective reduction.

258 ndant metal complex that is able to catalyze chemoselective reductive alkylation of various functiona

259 Stannous chloride catalyzed chemoselective reductive amination of a variety of carbo

260 thus formed to react with enals in a highly chemoselective, regioselective, diastereoselective and e

261 This chemoselective relay cyclization strategy was utilized i

262 This is done by regio- and chemoselective, remote, nondirected C(sp(3))-H hydroxyla

263 A chemoselective rhodium-catalyzed borylation has been dev

264 Reported herein is an exceptional chemoselective ring-opening/C(sp(3) )-C(sp(3) ) bond for

265 An efficient and chemoselective route for transforming BF2-BODIPYs to Et2

266 Herein, we demonstrate a chemoselective, salicylideneanilines-based COF (SA-COF),

267 Soft-Lewis basic complexants that facilitate chemoselective separation of the minor actinides from th

268 tial of soft-Lewis basic complexants for the chemoselective separation of trivalent actinides from la

269 mponent catalytic process that begins with a chemoselective, site-selective and diastereoselective co

270 These chemoselective solutions should have value to other prob

271 approach relies on the use of two successive chemoselective steps: (i) phosphoramidite coupling, and

272 This contribution reports the first chemoselective, stereospecific, and living polymerizatio

273 This one-pot procedure involves the chemoselective sulfonylation of 2-aminopyridines/pyrazin

274 Chemoselective Suzuki-Miyaura cross-coupling generally r

275 An efficient, metal and base-free, chemoselective synthesis of aryl-, heteroaryl-, and alky

276 A highly chemoselective synthesis of beta-ketophosphonates from p

277 ation is presented as a new strategy for the chemoselective synthesis of boronic esters.

278 An efficient tandem approach for the chemoselective synthesis of functionalized azido-pyranoq

279 lescopic approach has been developed for the chemoselective synthesis of substituted benzo[e]pyrido/p

280 This manuscript describes a one-pot, chemoselective synthesis of three 2,7-diaminosuberic aci

281 y enolsilanes with dienes provide a mild and chemoselective synthetic route to seven-membered carbocy

282 s aim to provide site-specific approaches by chemoselective targeting of canonical and noncanonical a

283 y, secondary, and tertiary C-H sites undergo chemoselective thioetherification of remote C-H bonds wi

284 ect synthesis of beta-Mannich products via a chemoselective three-component coupling of aryl aldehyde

285 le cycloisomerization, whereas it turned out chemoselective toward the formation of the double cycliz

286 The chemoselective transformation into these functional grou

287 ed amines can easily be accessed in a highly chemoselective transformation.

288 genic centers, (3) that several other unique chemoselective transformations essential to building the

289 lan by the use of highly atom-economical and chemoselective transformations in which alkynes played a

290 differentiated and can undergo a variety of chemoselective transformations to produce enantioenriche

291 or the development of a broad range of novel chemoselective transformations via open-shell electron p

292 carefully orchestrated sequence with several chemoselective transformations, including a designed cas

293 ha-diimine nickel catalysts that promote the chemoselective triborylation of benzylic C(sp(3))-H bond

294 n of amides electrophilic through a mild and chemoselective umpolung transformation, a broad range of

295 Our work establishes a unique chemoselective "unclickable" bioconjugation strategy to

296 The latter was found to be chemoselective using platinum(IV) oxide as the catalyst

297 and APC-2, a water-soluble congener) for the chemoselective visualization of Cu(II), a metal ion whic

298 hod of vat photopolymerization that provides chemoselective wavelength-control over material composit

299 mechanically distinct cascade reactions in a chemoselective way offers the new possibility for the sy

300 This method is scalable and chemoselective with broad functional-group tolerance.